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Amantadine

Amantadine is an antiviral and Parkinson's disease medicine used to prevent and treat influenza A and to treat parkinsonism, drug-induced movement problems, and (with Gocovri) dyskinesia and “off” episodes in Parkinson's disease.

Brand names GocovriOsmolex ERSymadineSymmetrelOsmolex
Drug class Influenza A M2 Protein Inhibitor
Rx Forms 3
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 64 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 7, 2026 🚨Recall on record
Amantadine at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Amantadine is an older standby, on the market since about 1968 and available as a generic, that prevents and treats influenza A by blocking a viral protein called M2, though today it is used mostly in Parkinson's disease, for parkinsonism and drug-induced movement problems, and as Gocovri for dyskinesia (uncontrolled movements) and “off” episodes. Most people tolerate it reasonably well, with dry mouth, dizziness, constipation and ankle swelling the usual complaints. Watch most closely for mood changes, depression, hallucinations or confusion, and report sudden blurry vision, which can signal swelling of the cornea (the clear front of the eye). If you take it for Parkinson's, never stop it suddenly.

Clinical pearls

  • Gocovri goes at bedtime, swallowed whole, and skip alcohol, which worsens dizziness, confusion and low blood pressure.
  • Kidney function sets the dose because amantadine builds up when kidneys are weak, and Gocovri is off-limits in end-stage kidney disease.
  • Antihistamines, bladder medicines and other anticholinergic drugs stack up with it, worsening dry mouth, constipation and trouble urinating.
  • On Gocovri, get the flu shot rather than the nasal spray vaccine, which contains weakened live virus.
How we write & review this content — our editorial policy →
How you get itPrescription only
Comes asCapsule, Tablet, Oral solution
Earliest FDA record1968
Companies listing it with the FDA35
FDA label last updatedSep 8, 2026
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Amantadine, written from its FDA label.

What Amantadine is used for

▾

Amantadine is used for infection prevention and for movement disorders, depending on the product.

  • Amantadine hydrochloride capsules, tablets and oral solution: prevention of influenza A.
  • Amantadine hydrochloride capsules, tablets and oral solution: treatment of uncomplicated influenza A respiratory illness, especially when started early.
  • Amantadine hydrochloride capsules, tablets and oral solution: parkinsonism and drug-induced extrapyramidal reactions.
  • Gocovri extended-release capsules: dyskinesia in Parkinson's disease in people on levodopa-based therapy.
  • Gocovri: add-on treatment to levodopa/carbidopa for “off” episodes in Parkinson's disease.

How Amantadine works

▾

Against influenza A, amantadine appears to block the virus from releasing its genetic material into your cells by interfering with the viral M2 protein. In some cases it also prevents virus assembly. It works against influenza A subtypes but has little or no activity against influenza B.

Some influenza A strains have reduced sensitivity to amantadine and can still cause typical flu illness. For Parkinson's disease, the exact mechanism is not known. It may act on dopamine nerve cells and weakly blocks NMDA receptors.

Amantadine dosage

▾

Amantadine is taken by mouth. Follow your prescriber and the product label.

  • Standard capsules, tablets and oral solution: once daily or split into two daily doses. A split schedule may reduce nervous system side effects.
  • Gocovri: once daily at bedtime, swallowed whole (do not crush, chew or divide), with or without food. Avoid alcohol.
  • Doses may need to be lowered for heart failure, leg swelling, low blood pressure on standing, or kidney problems.

Dosing details from the FDA-approved label

From the Amantadine prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Influenza A prophylaxis and treatment, adult
    • 200 mg daily as a single daily dose (two 100 mg tablets or capsules)
    • May be split into 100 mg twice a day
    • If CNS effects develop on once-a-day dosing, a split schedule may reduce them
  • Influenza A, persons 65 years of age or older
    • 100 mg daily
    • 100 mg dose also recommended for persons intolerant of 200 mg daily because of CNS or other toxicities
  • Influenza A, pediatric patients 1 yr. to 9 yrs. of age
    • Total daily dose calculated on the basis of 2 to 4 mg/lb/day (4.4 to 8.8 mg/kg/day)
    • Maximum: 150 mg per day
    • Weight-based dosing
  • Influenza A, pediatric patients 9 yrs. to 12 yrs. of age
    • Total daily dose is 200 mg given as one tablet of 100 mg twice a day
    • 100 mg daily dose has not been studied in this population
  • Parkinsonism, adult
    • 100 mg twice a day when used alone
    • Initial dose 100 mg daily for patients with serious associated medical illnesses or receiving high doses of other anti-parkinson drugs, after one to several weeks may be increased to 100 mg twice daily
    • Maximum: Up to 400 mg daily in divided doses for patients with non-optimal response at 200 mg daily (closely supervised)
    • If effectiveness falls off after a few months, benefit may be regained by increasing to 300 mg daily
  • Concomitant therapy with levodopa (Parkinsonism)
    • Amantadine held constant at 100 mg daily or twice daily while the levodopa daily dose is gradually increased to optimal benefit
  • Drug-induced extrapyramidal reactions, adult
    • 100 mg twice a day
    • Maximum: Up to 300 mg daily in divided doses for patients with non-optimal response at 200 mg daily
  • Impaired renal function, creatinine clearance 30 to 50 mL/min/1.73 m2
    • 200 mg 1st day and 100 mg each day thereafter
    • Kidney adjustment
  • Impaired renal function, creatinine clearance 15 to 29 mL/min/1.73 m2
    • 200 mg 1st day followed by 100 mg on alternate days
    • Kidney adjustment
  • Impaired renal function, creatinine clearance < 15 mL/min/1.73 m2, and patients on hemodialysis
    • 200 mg every 7 days
    • Same regimen for hemodialysis patients
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION The dose of Amantadine Hydrochloride may need reduction in patients with congestive heart failure, peripheral edema, orthostatic hypotension, or impaired renal function (see Dosage for Impaired Renal Function). Dosage for Prophylaxis and Treatment of Uncomplicated Influenza A Virus Illness Adult The adult daily dosage of Amantadine Hydrochloride is 200 mg; two 100 mg tablets or capsules as a single daily dose. The daily dosage may be split into one tablet or capsule of 100 mg twice a day. If central nervous system effects develop in once-a-day dosage, a split dosage schedule may reduce such complaints. In persons 65 years of age or older, the daily dosage of Amantadine Hydrochloride Tablets or Capsules is 100 mg. A 100 mg daily dose has also been shown in experimental challenge studies to be effective as prophylaxis in healthy adults who are not at high risk for influenza-related complications. However, it has not been demonstrated that a 100 mg daily dose is as effective as a 200 mg daily dose for prophylaxis, nor has the 100 mg daily dose been studied in the treatment of acute influenza illness. In recent clinical trials, the incidence of central nervous system (CNS) side effects associated with the 100 mg daily dose was at or near the level of placebo. The 100 mg dose is recommended for persons who have demonstrated intolerance to 200 mg of Amantadine Hydrochloride Tablets or Capsules daily because of CNS or other toxicities. Pediatric Patients 1 yr. to 9 yrs. of age The total daily dose should be calculated on the basis of 2 to 4 mg/lb/day (4.4 to 8.8 mg/kg/day), but not to exceed 150 mg per day. 9 yrs. to 12 yrs. of age The total daily dose is 200 mg given as one tablet of 100 mg twice a day. The 100 mg daily dose has not been studied in this pediatric population. Therefore, there are no data which demonstrate that this dose is as effective as or is safer than the 200 mg daily dose in this patient population. Prophylactic dosing should be started in anticipation of an influenza A outbreak and before or after contact with individuals with influenza A virus respiratory tract illness. Amantadine Hydrochloride should be continued daily for at least 10 days following a known exposure.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Amantadine side effects

▾

The most common side effects seen with Gocovri in trials were:

Common side effects

  • Hallucinations
  • Dizziness
  • Dry mouth
  • Swelling in the legs or ankles (peripheral edema)
  • Constipation
  • Falls
  • Lightheadedness when standing (orthostatic hypotension)
  • Nausea

When to get medical help

  • Call your doctor right away if you have thoughts of suicide, new depression, or unusual changes in mood or behavior.
  • Get help if you see or hear things that aren't there, or feel paranoid or confused.
  • Tell your doctor if you fall asleep during daily activities such as driving or eating.
  • Report sudden blurry vision, vision loss, or eye pain. These can signal corneal edema (swelling of the clear front of the eye).
  • Seek help for fainting or severe dizziness when standing.
  • Tell your doctor about new urges to gamble, spend money, binge eat, or have sex that you can't control.
  • Don't stop suddenly. Abrupt stopping can cause fever, stiff muscles, confusion, or worse Parkinson's symptoms.
  • Watch for swelling or heart failure symptoms if you have a history of heart failure or leg swelling.

Call your doctor promptly for hallucinations, mood changes, suicidal thoughts, fainting, vision changes, or uncontrollable urges.

Amantadine warnings and precautions

▾
  • Suicide and mental health: suicide attempts, some fatal, have been reported, including in people with no psychiatric history. Amantadine can worsen psychiatric problems.
  • Hallucinations and psychosis: people with a major psychotic disorder should ordinarily not take Gocovri.
  • Falling asleep suddenly: this has happened during activities like driving.
  • Dizziness and fainting: especially after starting or raising the dose.
  • Stopping suddenly: can cause fever, stiff muscles, confusion, or worse Parkinson's symptoms.
  • Corneal edema: sudden blurry vision or vision loss needs prompt evaluation.
  • Impulse control problems: gambling, spending, binge eating, or sexual urges.
  • Seizures, heart failure, glaucoma: watch closely if you have epilepsy or heart failure. Don't use with untreated angle closure glaucoma.
  • Overdose: deaths have been reported, especially in people with kidney problems.

Amantadine interactions

▾

These can change how amantadine works or add to side effects.

  • Alcohol: can worsen dizziness, confusion, and low blood pressure. Not recommended with Gocovri.
  • Other anticholinergic drugs: can increase dry mouth, constipation, and urinary retention.
  • Urine-acidifying or alkalinizing drugs and conditions: acidic urine speeds clearance, while alkaline urine can lead to buildup and more side effects.
  • Live attenuated influenza vaccines: amantadine may reduce their effectiveness. Inactivated vaccines may be used.
  • Other medicines with nervous system effects: use caution.

Interactions listed in the FDA-approved label

From the Amantadine prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Other anticholinergic drugs: Products with anticholinergic properties may potentiate the anticholinergic-like side effects of amantadine. Reduce the dose of the anticholinergic drug or of amantadine if atropine-like effects appear with concurrent use.
  • Drugs affecting urinary pH (e.g., carbonic anhydrase inhibitors, sodium bicarbonate): Excretion of amantadine increases rapidly when urine is acidic; alkaline urine may lead to accumulation of the drug with a possible increase in adverse reactions. Monitor for efficacy or adverse reactions under conditions that alter the urine pH to more acidic or alkaline, respectively.
  • Live attenuated influenza vaccines: Because of its antiviral properties, amantadine may interfere with the efficacy of live attenuated influenza vaccines. Live vaccines are not recommended during treatment; inactivated influenza vaccines may be used, as appropriate.
  • Alcohol: May increase the potential for CNS effects such as dizziness, confusion, lightheadedness, and orthostatic hypotension, and may result in dose-dumping. Concomitant use is not recommended.
Read the label’s full interactions text

7 DRUG INTERACTIONS Other Anticholinergic Drugs: Doses should be reduced if atropine-like effects occur ( 7.1 ) Drugs Affecting Urinary pH: Excretion increases with acidic urine; possible accumulation with urine change towards alkaline ( 7.2 ) Live Attenuated Influenza Vaccines: Not recommended during use ( 7.3 ) Alcohol: Concomitant use not recommended ( 7.4 ) 7.1 Other Anticholinergic Drugs Products with anticholinergic properties may potentiate the anticholinergic-like side effects of amantadine. The dose of anticholinergic drugs or of GOCOVRI should be reduced if atropine-like effects appear when these drugs are used concurrently. 7.2 Drugs Affecting Urinary pH The pH of the urine has been reported to influence the excretion rate of amantadine. Urine pH is altered by diet, drugs (e.g., carbonic anhydrase inhibitors, sodium bicarbonate), and clinical state of the patient (e.g., renal tubular acidosis or severe infections of the urinary tract). Since the excretion rate of amantadine increases rapidly when the urine is acidic, the administration of urine acidifying drugs may increase the elimination of the drug from the body. Alterations of urine pH towards the alkaline condition may lead to an accumulation of the drug with a possible increase in adverse reactions. Monitor for efficacy or adverse reactions under conditions that alter the urine pH to more acidic or alkaline, respectively. 7.3 Live Attenuated Influenza Vaccines Because of its antiviral properties, amantadine may interfere with the efficacy of live attenuated influenza vaccines. Therefore, live vaccines are not recommended during treatment with GOCOVRI. Inactivated influenza vaccines may be used, as appropriate.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿46 supplements and herbs with documented Amantadine interactions, ranked by severity Check Amantadine against a supplement or herb →

Before taking Amantadine

▾
  • Gocovri must not be used in end-stage renal disease. Other kidney impairment may require lower doses.
  • Tell your doctor about depression, suicidal thoughts, psychiatric illness, or substance abuse.
  • Tell your doctor about epilepsy, heart failure, leg swelling, or low blood pressure on standing.
  • Do not use with untreated angle closure glaucoma.
  • Pregnancy: animal studies suggest possible fetal harm, and human data are lacking.
  • Breastfeeding: amantadine passes into breast milk, and effects on the infant are unknown.
  • Children: Gocovri's safety and effectiveness in children have not been established.
  • Older adults: more hallucinations and falls, and kidney function may need monitoring.

Amantadine overdose

▾

Deaths have been reported from amantadine overdose. It can cause heart rhythm problems, breathing trouble, kidney problems, confusion, hallucinations, seizures, and coma. There is no specific antidote, so overdose is treated with supportive care and monitoring. Get emergency help right away.

What Amantadine does in the body

▾

Amantadine inhibits replication of influenza A subtypes H1N1, H2N2 and H3N2. It has little or no activity against influenza B. It does not appear to interfere with the response to inactivated influenza vaccine. In Parkinson's disease it may affect dopamine nerve cells and weakly blocks NMDA receptors. It can also cause anticholinergic-like effects such as dry mouth, urinary retention, and constipation.

How your body processes Amantadine

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Amantadine is well absorbed by mouth. Peak levels usually occur about 2 to 4 hours after a dose. The half-life is about 16 to 17 hours in healthy adults and longer in older adults. It is mostly removed unchanged by the kidneys. Levels rise and toxicity becomes more likely when kidney function is reduced.

How to store Amantadine

▾

Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) .

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

46

Supplements & herbs that interact with Amantadine

46 supplements and herbal products have documented interactions with Amantadine in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 3
  • Moderate · 32
  • Minor · 11
ACTIVATED CHARCOAL Major HENBANE Major SCOPOLIA Major ANGEL'S TRUMPET Moderate BACOPA Moderate BELLADONNA Moderate BETEL NUT Moderate BOXWOOD Moderate +38 more
Every supplement checked against Amantadine — ranked by severity The full interaction hub: 3 major · 32 moderate · 11 minor · every one linked to its full report. Check Amantadine against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Amantadine: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Amantadine — the kind of thing our pharmacy team would talk through with you at the counter.

What is amantadine used for?

▾
It depends on the product. Standard amantadine capsules, tablets and oral solution prevent and treat influenza A and treat parkinsonism and drug-induced movement problems. Gocovri is used only for Parkinson's disease dyskinesia and “off” episodes.

How should I take it?

▾
Take it by mouth exactly as your prescriber directs. Standard forms can be taken once a day or split into two doses. Gocovri is taken at bedtime and swallowed whole, with or without food. Avoid alcohol with Gocovri.

What side effects should I expect?

▾
Common ones include dizziness, dry mouth, constipation, leg swelling, and sometimes hallucinations. Stand up slowly to avoid lightheadedness. Call me or your doctor if you see things that aren't there or have mood changes.

When should I call my doctor right away?

▾
Call for thoughts of suicide, new depression, hallucinations, fainting, falling asleep during daily activities, or sudden blurry vision or eye pain. Also call about uncontrollable urges such as gambling or overspending.

Can I stop it suddenly?

▾
Please don't, especially if you take it for Parkinson's disease. Stopping abruptly can cause fever, stiff muscles, confusion, or worse symptoms. Talk to your prescriber about how to stop safely.

Is it safe in pregnancy or kidney disease?

▾
Animal studies suggest possible harm to a developing baby, so tell your doctor if you're pregnant or planning to be. Amantadine is cleared by the kidneys, so doses may need lowering with kidney problems. Gocovri must not be used in end-stage kidney disease.

Is Amantadine available over the counter?

▾
No. Amantadine is a prescription medicine: every Amantadine product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Amantadine first available?

▾
The earliest FDA record we hold for Amantadine is from 1968: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Amantadine was first used.

Who makes Amantadine?

▾
35 companies currently list Amantadine products in the FDA's NDC Directory, including Bryant Ranch Prepack, Proficient Rx LP, Chartwell RX, LLC. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Amantadine on HelloPharmacist

📊Amantadine supplement interactions46 checked — ranked by severity 🌿Drug & Supplement CheckerAmantadine vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Amantadine NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Amantadine Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Amantadine forms and strengths (how it comes)

Amantadine is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Amantadine inactive ingredients by manufacturer.

Capsule

By mouth
Brands Gocovri
How this form is used
What it may be used for
  • Amantadine hydrochloride capsules are used to prevent and treat influenza A and to treat parkinsonism and drug-induced extrapyramidal reactions.
  • Gocovri is used for dyskinesia in Parkinson's disease with levodopa-based therapy, and as add-on treatment for “off” episodes.
Important instructions
  • Amantadine hydrochloride capsules may be taken once daily or split into two daily doses.
  • Gocovri is taken once daily at bedtime and swallowed whole, with or without food.
  • Gocovri can be opened and sprinkled on a small amount of soft food if needed.
  • Gocovri is not substitutable with other amantadine immediate- or extended-release products.
Available strengths 3 strengths
68.5 mg 100 mg 137 mg
81 FDA-listed product records ⓘ

Tablet

By mouth
How this form is used
What it may be used for
  • Amantadine hydrochloride tablets are used to prevent and treat influenza A and to treat parkinsonism and drug-induced extrapyramidal reactions.
Important instructions
  • Amantadine hydrochloride tablets may be taken once daily or split into two daily doses.
  • If nervous system effects occur on once-daily dosing, a split schedule may help.
Available strengths 1 strength
100 mg
20 FDA-listed product records ⓘ

Oral solution

By mouth
How this form is used
What it may be used for
  • Amantadine hydrochloride oral solution is used to prevent and treat influenza A and to treat parkinsonism and drug-induced extrapyramidal reactions.
Important instructions
  • Amantadine hydrochloride oral solution may be taken once daily or split into two daily doses, measured in teaspoonfuls.
Available strengths 2 strengths
50 mg/5 mL 100 mg/10 mL
17 FDA-listed product records ⓘ

Amantadine on the U.S. market: products, makers and brands

How Amantadine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

35 companies list 61 Amantadine product records with the FDA, mostly as capsule, tablet, oral solution; the earliest marketing or approval year on record is 1968. Brand names on the directory include Gocovri, Osmolex ER, Symadine and 2 more; the rest are generics.

3
Dose forms ⓘ
35
Labelers (makers, repackagers, distributors)
4
Brand names
61
FDA-listed product records ⓘ
1968
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (10) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack11%
Proficient Rx LP7%
Chartwell RX, LLC5%
Coupler LLC5%
Direct_Rx5%
Adamas Pharma, LLC3%
Other makers64%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Amantadine is used (Medicaid data)

A general measure of how commonly Amantadine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Amantadine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

210,143
Medicaid prescriptions filled (Q1–Q4 2025)
$8.6M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Amantadine prescribed? Of the 1,601 medications we measure, Amantadine ranks #386 by Medicaid prescriptions — more than 76% of them.

Where Amantadine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #386 of 1,601
#381 Aflibercept Injection 214,860 Rx #382 Cefuroxime 214,273 Rx #383 Sevelamer 212,246 Rx #384 Amiodarone 212,033 Rx #385 Icosapent Ethyl 211,612 Rx #386 Amantadine 210,143 Rx #387 Valsartan and Hydrochl... 208,319 Rx #388 Fremanezumab-vfrm Inje... 205,598 Rx #389 Solifenacin 205,369 Rx #390 Water 204,877 Rx #391 Metformin / Sitaglipti... 203,107 Rx

Utilization by Amantadine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 100 mg oral capsule is the most-dispensed Amantadine product — about 49% of these Medicaid prescriptions.

amantadine hydrochloride 100 MG Oral Capsule Most dispensed

102,493 Medicaid prescriptions (Q1–Q4 2025) 49% of Amantadine prescriptions shown $1.7M gross reimbursement (before rebates) ≈ $17 per prescription (gross)

Summed across the 17 of 116 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 849389

amantadine hydrochloride 100 MG Oral Tablet

86,206 Medicaid prescriptions (Q1–Q4 2025) 41% of Amantadine prescriptions shown $2.7M gross reimbursement (before rebates) ≈ $31 per prescription (gross)

Summed across the 6 of 26 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 849395

amantadine hydrochloride 10 MG/ML Oral Solution

20,418 Medicaid prescriptions (Q1–Q4 2025) 10% of Amantadine prescriptions shown $540,043 gross reimbursement (before rebates) ≈ $26 per prescription (gross)

Summed across the 3 of 30 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 849385

24 HR amantadine 137 MG Extended Release Oral Capsule

979 Medicaid prescriptions (Q1–Q4 2025) <1% of Amantadine prescriptions shown $3.5M gross reimbursement (before rebates) ≈ $3,586 per prescription (gross)

Summed across the 1 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1944370

24 HR amantadine 68.5 MG Extended Release Oral Capsule

47 Medicaid prescriptions (Q1–Q4 2025) <1% of Amantadine prescriptions shown $99,130 gross reimbursement (before rebates) ≈ $2,109 per prescription (gross)

Summed across the 1 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1944380

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Amantadine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 28 of 184 listed Amantadine NDCs with Medicaid activity.

Compare Amantadine products

A representative set of FDA-listed product records for Amantadine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 61 of 61 products — FDA National Drug Code Directory. See every product, package size and price: browse all 61 Amantadine NDCs →

Amantadine side effects reported to the FDA (FAERS)

After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Amantadine — a signal of what to watch for, not proof the drug caused it.

The effects most often named in FDA reports that mention Amantadine are fall, hallucination, fatigue; about 64% of the reports were classed as serious. These are voluntary reports, so they show what people report, not how often it happens.

20,181
Reports mentioning it
64%
Reported as serious
12
Distinct effects shown
Most reported effects
Fall
2,155
Hallucination
1,556
Fatigue
1,405
Dyskinesia
1,277
Gait Disturbance
1,186
Dizziness
1,149
Tremor
1,016
Death
1,011
Nausea
859
Asthenia
856
Age groups
Adult · 927Elderly · 821Adolescent · 27Child · 26Neonate · 4

Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Amantadine in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.

Amantadine FDA approval history

How Amantadine went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.

Amantadine was first approved by the FDA in 1968 (Brand: SYMMETREL · Endo Pharms); the first generic version was approved in 1987. It remains available in U.S. pharmacies today.

1968
Brand approved
Brand: SYMMETREL · Endo Pharms
1987
First generic approved
Lower-cost ANDA competition begins
2026
Available today
Active in U.S. pharmacies

Source: Drugs@FDA.

Amantadine recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list one Amantadine recall since July 2021. It is still ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Ongoing Class II Feb 13, 2026 · AvKARE
Failed Dissolution Specifications: This recall has been initiated due to an Out of Specification finding in dissolution.
  • Amantadine HCl, Capsules, UPS, 100 mg, 50 Capsules (5 x 10) unit dose, Rx Only, Manufactured for: AvKARE, Pulaski, TN 38478, www.avkare.com, NDC 50268-069-15. Lots: Lot # 49261, Exp: 04/30/27 FDA record D-0341-2026 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Amantadine RxCUI 620 5 dose forms · 8 strengths
  2. Dose form (SCDF) Extended Release Oral Tablet RxCUI 2044713 No current FDA listing
    Clinical drug / strength (SCD) 24 HR amantadine 129 MG RxCUI 2044714 24 HR amantadine 193 MG RxCUI 2044724 24 HR amantadine 258 MG RxCUI 2044730
  3. Dose form (SCDF) Oral Capsule RxCUI 370558 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 100 MG RxCUI 849389
  4. Dose form (SCDF) Oral Solution RxCUI 702116 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 10 MG/ML RxCUI 849385
  5. Dose form (SCDF) Oral Tablet RxCUI 370559 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 100 MG RxCUI 849395

Look up RxCUI 620 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Amantadine costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Solution · Oral 50 mg/5 mL $0.050 per mL NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Amantadine brand names

Amantadine is sold under 5 brand names in the FDA directory — Gocovri, Osmolex ER, Symadine, Symmetrel and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Gocovri Osmolex ER Symadine Symmetrel Osmolex

Who makes Amantadine: manufacturers and labelers

35 companies list Amantadine products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, Proficient Rx LP, Chartwell RX, LLC. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Bryant Ranch Prepack 7 Proficient Rx LP 4 Chartwell RX, LLC 3 Coupler LLC 3 Direct_Rx 3 Adamas Pharma, LLC 2 Alembic Pharmaceuticals Inc. 2 Alembic Pharmaceuticals Limited 2 American Health Packaging 2 AvKARE 2 AvPAK 2 Marlex Pharmaceuticals Inc 2 NCS HealthCare of KY, LLC dba Vangard Labs 2 Strides Pharma Inc. 2 Supernus Pharmaceuticals 2 Upsher-Smith Laboratories, LLC 2 A-S Medication Solutions 1 Atlantic Biologicals Corp. 1 Advagen Pharma Limited 1 Bajaj Medical, Llc 1 Bionpharma Inc. 1 Cardinal Health 107, LLC 1 Chartwell Governmental & Specialty RX, LLC. 1 Epic Pharma Llc 1

…and 11 more on the FDA NDC directory.

Amantadine drug class (RxNorm)

Amantadine belongs to the Influenza A M2 Protein Inhibitor class.

Pharmacologic class Influenza A M2 Protein Inhibitor
Drug family (ATC) Adamantane derivatives
How it works M2 Protein Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Amantadine page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Sep 8, 2026
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Amantadine.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Amantadine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
64
Finished products in the current FDA directory
61
Companies listing them (makers, repackagers, distributors)
35
FDA labeler codes behind them ⓘ
38
Linked representative label ⓘ
Supernus Pharmaceuticals
Linked label effective
Sep 8, 2026
Composite sections available
25
Linked SPL Set ID
2bee0631-0028-1314-e063-6394a90aaaed
Linked SPL Document ID
5afd8bfc-0c3f-131d-e063-6394a90adef9
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Supernus Pharmaceuticals is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →