Amitriptyline With Passionflower - Interaction Details

Answer

While there is no specific interaction between amitriptyline and passionflower, they both can have sedative effects and these effects can be potentiated when both are used together.

Additional Details

We have this interaction presented in more detail on our dedicated 'amitriptyline - passionflower' interaction page.

Basically, both amitriptyline and passionflower can have sedative effects and those effects can be heightened when both are taken together.

Passionflower contains several that have relaxant properties.

Studies suggest that these compounds bind to specific receptors called GABA(A) and GABA(B) and can increase the amounts of GABA in the brain. GABA is commonly described as a 'inhibitory' neurotranmsittrer, and is associated with sedation and calmness.

The specific compounds in passionflower that have been identified as being responsible for these effects include

• Isovitexin
• Benzoflavone
• Chrysin
• Maltol

Amitriptyline, a prescription medication, has a variety of effects on a number of different neurotransmitters (such as serotonin, norepinephrine, and acetylcholine). It is well known to have sedative effects, especially when first starting the medication.

It's unlikely there is any major interaction between amitriptyline and passionflower to be worried about aside from the additive sedative effects, but that one is certainly good to know about.

You don't want to partake in any activities that require mental alertness, such as driving, when taking the combination for the first time, not knowing how it will affect you.

Final Words

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