Medication interaction hub

What Supplements Interact with Pazopanib?

Pazopanib brand name: Votrient. Every interaction below applies to the brands too.

349 Interactions 14 Major 297 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Pazopanib? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Pazopanib against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Take a careful look before mixing supplements with pazopanib (Votrient), an oral pill for advanced kidney cancer and certain sarcomas. Fourteen of the 349 ingredients on file are rated major, grapefruit among them, since it can raise pazopanib levels enough to intensify side effects. The biggest cluster, over 200 ingredients, adds bleeding risk, and roughly 120 more can shift the drug's blood level through the CYP3A4 enzyme it depends on (St. John's wort pushes levels down).

Pazopanib can already strain the liver, so the 38 entries that add liver stress, alcohol included, carry extra weight here. Thirteen can lengthen the heart's QT interval, a rhythm disturbance pazopanib itself can cause, and a handful can blunt absorption if swallowed close to your dose, so space those well apart. With bleeding and liver effects dominating the list, your oncology pharmacist should hear about every supplement before it goes in your pillbox.

— , Clinical Pharmacist · July 18, 2026

Major 14 Moderate 297 Minor 38 No known interaction 1,103

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Pazopanib: Top Interactions at a Glance

The Pazopanib supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 349 interacting ingredients — plus 1,103 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Pazopanib Combinations Today

The Pazopanib + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Tree Of Heaven + Pazopanibi

Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.

Read the full interaction Minor Likelihood Unlikely Algal Oil + Pazopanibi

Theoretically, algal oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Flaxseed Oil + Pazopanibi

Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.

Read the full interaction Moderate Likelihood Possible Kiwi + Pazopanibi

Clinical research suggests that kiwi inhibits platelet aggregation.

Read the full interaction Moderate Likelihood Possible Bromelain + Pazopanibi

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Major Likelihood Possible Asarabacca + Pazopanibi

Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Read the full interaction
The complete list

Every Supplement Checked Against Pazopanib

All 1,452 ingredients in our database, ranked by severity — 349 with a Pazopanib interaction on file and 1,103 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Pazopanib?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Tree Of Heaven with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or antic...

Full Tree Of Heaven + Pazopanib answer

Can you take Algal Oil with Pazopanib?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algal oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Algal Oil + Pazopanib answer

Can you take Flaxseed Oil with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk...

Full Flaxseed Oil + Pazopanib answer

Can you take Kiwi with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Clinical research suggests that kiwi inhibits platelet aggregation.

Full Kiwi + Pazopanib answer

Can you take Bromelain with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Bromelain + Pazopanib answer

Can you take Japanese Persimmon with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is concern that Japanese persimmon leaf constituents might potentiate effects of anticoagulant and antiplatelet drugs.

Full Japanese Persimmon + Pazopanib answer

Can you take Jequirity with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that constituents of jequirity beans can inhibit platelet aggregation.

Full Jequirity + Pazopanib answer

Can you take Jiaogulan with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jiaogulan might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Jiaogulan + Pazopanib answer

Can you take K2/spice with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, K2/spice might have an additive effect with drugs that prolong the QT interval and increase the risk of ventricular arrhythmi...

Full K2/spice + Pazopanib answer

Can you take Kava with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using kava with hepatotoxic drugs might increase the risk of liver damage.

Full Kava + Pazopanib answer

Can you take Kefir with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kefir might increase the risk of bacterial and yeast infections in patients taking immunosuppressants.

Full Kefir + Pazopanib answer

Can you take Khella with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, khella might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Khella + Pazopanib answer

Can you take Kinetin with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that kinetin inhibits human platelet aggregation and activation.

Full Kinetin + Pazopanib answer

Can you take Kratom with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. CYP3A4 inhibitors might increase the concentrations and clinical effects of kratom's primary active alkaloid mitragynine.

Full Kratom + Pazopanib answer

Can you take Krill Oil with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Krill Oil + Pazopanib answer

Can you take Kudzu with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Kudzu + Pazopanib answer

Can you take L-arginine with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of...

Full L-arginine + Pazopanib answer

Can you take Larch Arabinogalactan with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.

Full Larch Arabinogalactan + Pazopanib answer

Can you take Lemongrass with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.

Full Lemongrass + Pazopanib answer

Can you take Lentinan with Pazopanib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Laboratory research suggests that lentinan might increase the activity of cytochrome P450 3A4 (CYP3A4).

Full Lentinan + Pazopanib answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Pazopanib is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Pazopanib, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Pazopanib sits in 11 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Pazopanib through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Pazopanib through this category.

Immunosuppressants 53 ingredients

Medications that damp down the immune system. Supplements that stimulate immunity can work against them.

53 of the supplement ingredients on this page reach Pazopanib through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Pazopanib through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Pazopanib through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Pazopanib through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Pazopanib through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Pazopanib through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Pazopanib through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Pazopanib through this category.

Pazopanib (Votrient) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Pazopanib through this category.

About Pazopanib

Pazopanib is a targeted cancer medicine used to treat advanced renal cell carcinoma (kidney cancer) and advanced soft tissue sarcoma in adults.

Generic name: Pazopanib  ·  Brand name: Votrient.

See the full Pazopanib drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Pazopanib

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Pazopanib.

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Pharmacist Counseling Corner

Pazopanib & Supplements: Common Questions

What supplements interact with Pazopanib?
In our interaction database, 349 supplement and herbal ingredients have an interaction with Pazopanib on file — 14 rated major, 297 moderate, and 38 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Pazopanib supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Activated Charcoal, Arsenic and Beer, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Pazopanib?
That depends entirely on which supplement. The honest answer for Pazopanib is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Votrient have the same supplement interactions as Pazopanib?
Yes — Votrient all contain Pazopanib, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Pazopanib and my other medications?
This page covers Pazopanib against supplements and herbal ingredients. Checking Pazopanib against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Pazopanib drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.