Herb & supplement monograph

Rice Bran Arabinoxylan Compound Drug Interactions, Uses, Effectiveness, Safety & More

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Rice Bran Arabinoxylan Compound Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Rice Bran Arabinoxylan Compound drug interaction appears low for most people, though those taking medicines that suppress the immune system are the exception. None of the listed interactions are rated major, and every one traces back to a single theoretical concern involving one class of medications.

Interactions deserving the most attention

The interactions that matter most involve immunosuppressants, such as cyclosporine, azathioprine, and similar transplant or autoimmune medicines. Rice bran arabinoxylan compound has been shown in lab and human research to stimulate immune cell activity, so in theory it could work against drugs that are meant to calm the immune system. Because transplant medicines have a narrow margin for error, even a theoretical effect deserves caution in this group.

What the rest of the list means

Although the list of interacting medications looks long, it reflects one shared concern spread across the many drugs in this single class, not dozens of separate problems. The interaction is graded as theoretical, meaning it is based on the supplement's known immune-stimulating activity rather than documented harm in people taking these medicines together.

Check your medications against Rice Bran Arabinoxylan Compound

Based on HelloPharmacist’s Rice Bran Arabinoxylan Compound interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Rice Bran Arabinoxylan Compound

121 medications have a known interaction with Rice Bran Arabinoxylan Compound, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
6-mercaptopurinePurinethol
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + 6-mercaptopurine interaction 6-mercaptopurine drug page: uses, dosage & side effects
AbrocitinibCibinqo
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AdalimumabHumira
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Adalimumab interaction Adalimumab drug page: uses, dosage & side effects
Adalimumab-adazHyrimoz
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Adalimumab-adaz interaction
Adalimumab-adbmCyltezo
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Adalimumab-adbm interaction
Adalimumab-afzbAbrilada
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Adalimumab-afzb interaction
Adalimumab-attoAmjevita
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Adalimumab-atto interaction
Adalimumab-bwwdHadlima
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Adalimumab-bwwd interaction
Adalimumab-fkjpHulio
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Adalimumab-fkjp interaction
AlefaceptAmevive
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Alefacept interaction
AlemtuzumabCampath
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Alemtuzumab interaction Alemtuzumab drug page: uses, dosage & side effects
Anifrolumab-fniaSaphnelo
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Anifrolumab-fnia interaction Anifrolumab-fnia drug page: uses, dosage & side effects
Antithymocyte GlobulinThymoglobulin
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Antithymocyte Globulin interaction
AtezolizumabTecentriq
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Atezolizumab interaction Atezolizumab drug page: uses, dosage & side effects
AzamuneImmunoprin
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Azamune interaction
AzathioprineAzamune, Imuran
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Azathioprine interaction Azathioprine drug page: uses, dosage & side effects
BasiliximabSimulect
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Basiliximab interaction Basiliximab drug page: uses, dosage & side effects
Beclometasone DipropionateBecotide
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Beclometasone Dipropionate interaction
BeclomethasoneBeclovent, Vanceril
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Beclomethasone interaction Beclomethasone drug page: uses, dosage & side effects
Beclomethasone DipropionateQNASL, Qvar
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Beclomethasone Dipropionate interaction Beclomethasone Dipropionate drug page: uses, dosage & side effects
BetamethasoneCelestone, Diprolene AF, Diprosone
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Betamethasone interaction Betamethasone drug page: uses, dosage & side effects
Betamethasone DipropionateSernivo
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Betamethasone Dipropionate interaction Betamethasone Dipropionate drug page: uses, dosage & side effects
Betamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Betamethasone Dipropionate, Calcipotriene interaction
Betamethasone ValerateLuxiq
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Betamethasone Valerate interaction Betamethasone Valerate drug page: uses, dosage & side effects
Bimekizumab-bkzxBimzelx
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Bimekizumab-bkzx interaction
CiclesonideAlvesco, Omnaris, Zetonna
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Ciclesonide interaction Ciclesonide drug page: uses, dosage & side effects
CisplatinPlatinol-AQ
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Cisplatin interaction Cisplatin drug page: uses, dosage & side effects
CladribineLeustatin, Mavenclad
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Cladribine interaction Cladribine drug page: uses, dosage & side effects
CopanlisibAliqopa
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Copanlisib interaction
Cortisone AcetateCortisone Tablets, Cortone
Moderate Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Read the full Rice Bran Arabinoxylan Compound + Cortisone Acetate interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Rice Bran Arabinoxylan Compound combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Rice Bran Arabinoxylan Compound affects

Every type of medication (drug category) Rice Bran Arabinoxylan Compound is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Rice Bran Arabinoxylan Compound interacts with
Immunosuppressants
Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system. In laboratory and human research, rice bran arabinoxylan compound has been shown to stimulate the activity of immune cells.
Some immunosuppressants include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Likelihood Possible Evidence D
Monograph

Rice Bran Arabinoxylan Compound: Uses, Safety & Side Effects

The bottom line

Rice Bran Arabinoxylan Compound (often sold under brand names like MGN-3 or BioBran) is a processed fiber from rice bran treated with mushroom enzymes, marketed mainly as an immune booster. Early small studies suggest it may affect certain immune cells, but high-quality human evidence is very limited, and it should never replace standard medical care. Talk with your pharmacist or doctor before using it, especially during cancer treatment.

Family
Poaceae
Part used
Rice bran (outer layer of Oryza sativa), modified with enzymes from shiitake mushroom
Common forms
Capsules, tablets, powder, granules
People commonly use it for
  • Immune support
  • Support during cancer treatment
  • Boosting natural killer (NK) cell activity
  • General wellness in older adults
  • Fatigue and quality of life support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated in short-term studies, but long-term safety and quality data are limited.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Rice Bran Arabinoxylan Compound is a dietary supplement made from rice bran, which is the nutrient-rich outer layer of the rice grain. To make it, the rice bran is treated with enzymes that come from shiitake mushroom. This processing breaks down the fiber into smaller pieces called arabinoxylans, which are thought to be more active in the body.

You may see this product sold under brand names such as MGN-3 or BioBran. It is most often marketed as an immune-supporting supplement and is popular among people looking for general wellness support or extra support during illness.

It comes in capsules, tablets, powders, and granules. Rice is grown widely around the world, but this particular product is a specially manufactured compound rather than something you can get from simply eating rice or rice bran.

How it works

The active parts of this product are arabinoxylans — chains of plant sugars (fibers) released when rice bran is treated with mushroom enzymes. Because these pieces are smaller than natural rice bran fiber, researchers believe the body may interact with them differently.

Laboratory and animal studies suggest arabinoxylans may act on the immune system, possibly by stimulating immune cells like natural killer (NK) cells, T cells, and B cells, and by affecting signaling chemicals called cytokines. Some research suggests possible antioxidant effects as well.

It is important to remember that most of this information comes from test-tube and animal research. What happens in a lab dish does not always happen the same way in the human body, so these mechanisms are still considered theories rather than proven effects.

Effectiveness

Does Rice Bran Arabinoxylan Compound work?

Evidence overview · 5 uses evaluated
5 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Rice Bran Arabinoxylan Compound, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 5 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Chronic fatigue syndrome (CFS)
Rating & evidence shown verbatim from Natural Medicines

Evidence from an early, uncontrolled, observational study suggested that rice bran arabinoxylan compound can reduce fatigue and increase natural killer cell activity in patients with CFS. However, results from a more recent, higher quality clinical study shows that taking rice bran arabinoxylan compound 2 grams three times daily for 8 weeks does not improve fatigue, anxiety, depression, or other symptoms related to CFS compared to placebo. However, due to the small size of this latter study, the possibility of type II error (false negative) cannot be ruled out.

Sources Ref 98693
Insufficient Reliable Evidence To Rate Hepatitis C
Rating & evidence shown verbatim from Natural Medicines

A small preliminary clinical trial shows that taking rice bran arabinoxylan compound 1 gram daily for 3 months is as effective for reducing viral load as PEGylated interferon 180 micrograms weekly subcutaneously plus ribavirin 1000 or 1200 mg daily based on weight in patients with hepatitis C virus genotype 4. There was no effect on liver enzymes. A larger, well-designed trial is needed to confirm these results.

Sources Ref 98688
Insufficient Reliable Evidence To Rate HIV/AIDS
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research in patients on stable antiretroviral therapy for HIV shows that taking a specific rice bran arabinoxylan product (Biobran/MGV-3, Daiwa Pharmaceuticals) 1 gram three times daily for 6 months does not increase CD4+ cell count, reduce blood pressure, or improve markers of liver and kidney function when compared with placebo. However, it does decrease CD8+ cell count when compared with placebo. This study may have been inadequately powered to detect a difference between groups.

Insufficient Reliable Evidence To Rate Liver cancer
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research in patients with stage I or II hepatocellular carcinoma shows that taking rice bran arabinoxylan compound 1 gram daily for 12 months in conjunction with interventional therapy may increase survival after 2 years and reduce the risk of recurrence compared to interventional therapy alone. Survival after the second year was 35% for patients treated with rice bran arabinoxylan compound plus interventional therapy compared to only 6.7% for patients treated with interventional therapy alone. Recurrence of the disease occurred in 31.6% of patients treated with rice bran arabinoxylan compound plus interventional therapy compared to 46.7% of patients treated with interventional therapy alone. Interventional therapy consisted of transarterial oily chemoembolization (TOCE), percutaneous ethanol injection therapy (PEIT), and/or radiofrequency ablation (RFA).

Sources Ref 98692
Insufficient Reliable Evidence To Rate Quality of life
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research in healthy adults at least 56 years of age shows that taking a specific rice bran arabinoxylan product (Biobran/MGV-3, Daiwa Pharmaceuticals) 250 mg divided three times daily for 3 months improves physical and mental health-related quality of life scores when compared with placebo.

Sources Ref 104768

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

In short-term studies, Rice Bran Arabinoxylan Compound has generally been well tolerated by most people. Still, long-term safety has not been well studied, and supplement quality can vary between brands since these products are not tightly regulated.

People who should be especially careful include those with weakened immune systems, those undergoing cancer treatment, and people with serious medical conditions. Because this product may affect the immune system, anyone with an autoimmune condition or who takes immune-related medicines should check with a doctor or pharmacist first.

For pregnancy and breastfeeding, there is not enough reliable safety information. Because of this lack of data, it is best to avoid using it if you are pregnant or breastfeeding.

People with rice allergies should also use caution. As with any supplement, talk to your pharmacist or doctor before starting, especially if you take other medicines or have a chronic health condition.

Side effects

Reported side effects are usually mild. Some people may notice digestive symptoms such as mild stomach upset, bloating, gas, or loose stools, which can happen with fiber-based products.

Serious side effects have not been commonly reported, but because the research is limited, rare reactions cannot be ruled out. People with a rice allergy could potentially have an allergic reaction. Stop using the product and seek medical care if you develop signs of an allergic reaction such as rash, itching, swelling, or trouble breathing.

Rice Bran Arabinoxylan Compound: Reported Adverse Effects

Documented safety reports on Rice Bran Arabinoxylan Compound from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Nausea and vomiting Gastrointestinal

Orally, rice bran arabinoxylan compound has been reported to cause one case of mild nausea and one case of irritable bowel symptoms in a clinical trial.

  1. McDermott C, Richards SC, Thomas PW, Montgomery J, Lewith G. A placebo-controlled, double-blind, randomized controlled trial of a natural killer cell stimulant (BioBran MGN-3) in chronic fatigue syndrome. QJM. 2006;99(7):461-8.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official or standardized dose for Rice Bran Arabinoxylan Compound. Amounts used in studies have varied, and products differ in strength and form.

The safest approach is to follow the directions on the product label and not exceed the recommended amount. Because doses and product quality vary so much, it is a good idea to check with your pharmacist or doctor before starting, especially if you have a health condition or take other medicines.

Pregnancy & Breastfeeding

Rice Bran Arabinoxylan Compound & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Rice Bran Arabinoxylan Compound & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 13 references that drive our Rice Bran Arabinoxylan Compound monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ghoneum M, Namatalia G, Kim C. Effect of MGN-3 on human natural killer cell activity and interferon-y synthesis in vitro. FASEB 1996;10:26-32.
  2. Ghoneum M, Jewett A. Synergistic effect of modified arabinoxylane (MGN-3) and low dose of recombinant IL-2 on human NK cell activity and TNF-a production. American Academy of Anti-Aging Medicine, Education Conference 1998.
  3. Salama H, Medhat E, Shaheen M, Zekri AN, Darwish T, Ghoneum M. Arabinoxylan rice bran (Biobran) suppresses the viremia level in patients with chronic HCV infection: A randomized trial. Int J Immunopathol Pharmacol. 2016;29(4):647-653. PubMed
  4. Ghoneum M, Agrawal S. Mgn-3/biobran enhances generation of cytotoxic CD8+ T cells via upregulation of dec-205 expression on dendritic cells. Int J Immunopathol Pharmacol. 2014;27(4):523-30. PubMed
  5. Cholujova D, Jakubikova J, Czako B, et al. MGN-3 arabinoxylan rice bran modulates innate immunity in multiple myeloma patients. Cancer Immunol Immunother. 2013;62(3):437-45. PubMed
  6. Ghoneum M, Agrawal S. Activation of human monocyte-derived dendritic cells in vitro by the biological response modifier arabinoxylan rice bran (MGN-3/Biobran). Int J Immunopathol Pharmacol. 2011;24(4):941-8.
  7. Bang MH, Van Riep T, Thinh NT, et al. Arabinoxylan rice bran (MGN-3) enhances the effects of interventional therapies for the treatment of hepatocellular carcinoma: a three-year randomized clinical trial. Anticancer Res. 2010;30(12):5145-51.
  8. McDermott C, Richards SC, Thomas PW, Montgomery J, Lewith G. A placebo-controlled, double-blind, randomized controlled trial of a natural killer cell stimulant (BioBran MGN-3) in chronic fatigue syndrome. QJM. 2006;99(7):461-8. PubMed
  9. Ghoneum M, Matsuura M. Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/biobran). Int J Immunopathol Pharmacol. 2004;17(3):283-92. PubMed
  10. Ghoneum M, Jewett A. Production of tumor necrosis factor-alpha and interferon-gamma from human peripheral blood lymphocytes by MGN-3, a modified arabinoxylan from rice bran, and its synergy with interleukin-2 in vitro. Cancer Detect Prev. 2000;24(4):314-2
  11. Elsaid AF, Fahmi RM, Shaheen M, Ghoneum M. The enhancing effects of Biobran/MGN-3, an arabinoxylan rice bran, on healthy old adults' health-related quality of life: a randomized, double-blind, placebo-controlled clinical trial. Qual Life Res. 2020 Feb;29( PubMed
  12. Lewis JE, Atlas Bsn SE, Abbas MH, et al. The novel effects of a hydrolyzed polysaccharide dietary supplement on immune, hepatic, and renal function in adults with HIV in a randomized, double-blind, placebo-control trial. J Diet Suppl. 2020;17(4):429-441. PubMed
  13. Lewis JE, Atlas SE, Abbas MH, et al. Cardiovascular, endothelial function, and immune markers in response to treatment with a polysaccharide in HIV + adults in a randomized, double-blind placebo-controlled trial. J Clin Transl Res. 2020 Apr 13;5(3):140-14 DOI
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Rice Bran Arabinoxylan Compound: Common Questions

What is Rice Bran Arabinoxylan Compound used for, and does it work?
People use Rice Bran Arabinoxylan Compound for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Rice Bran Arabinoxylan Compound interact with prescription medications?
Yes. We list 121 medications with a known interaction with Rice Bran Arabinoxylan Compound. Use the checker above to see how Rice Bran Arabinoxylan Compound interacts with a specific drug.
How are Rice Bran Arabinoxylan Compound interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Rice Bran Arabinoxylan Compound with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Rice Bran Arabinoxylan Compound interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Rice Bran Arabinoxylan Compound used for?
It is mainly marketed as an immune-support supplement and is sometimes used by people hoping to boost immune cell activity or support general wellness. The evidence behind these uses is limited and not strong enough to prove it works.
Is it the same as eating rice or rice bran?
No. It is a specially processed product where rice bran is treated with mushroom enzymes to break the fiber into smaller pieces. You cannot get the same compound just by eating rice.
Can it treat or cure cancer?
No. There is no reliable evidence that it treats or cures cancer, and it should never replace standard cancer treatment. If you are in cancer care, talk to your oncology team before using any supplement.
Is it safe to take during pregnancy or breastfeeding?
There is not enough safety information, so it is best to avoid it while pregnant or breastfeeding. Check with your doctor or pharmacist before using any supplement during these times.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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