Tacrolimus

Tacrolimus (Astagraf XL, Envarsus XR, Prograf) is used along with other medications to prevent rejection (attack of a transplanted organ by the immune system of a person receiving the organ) in people who have received a kidney transplant. Tacrolimus (Prograf) is also used along with other medications to prevent rejection in people who have received a liver, lung, or heart transplant. Tacrolimus is in a class of medications called immunosupressants. It works by decreasing the activity of the immune system to prevent it from attacking the transplanted organ.

Tacrolimus comes as a capsule, granules for oral suspension (to be mixed with liquid), an extended-release (long acting) capsule, and an extended-release tablet to take by mouth. The immediate-release capsules (Prograf) and oral suspension (Prograf) are usually taken twice a day (12 hours apart). You may take the immediate-release capsules and oral suspension either with or without food, but be sure to take it the same way each time. The extended-release capsules (Astagraf XL) or extended-release tablets (Envarsus XR) are usually taken every morning on an empty stomach at least 1 hour before or breakfast or at least 2 hours after breakfast. Take tacrolimus at the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tacrolimus exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are taking the granules for oral suspension, you will need to mix it with room temperature water before use. Place 1 to 2 tablespoons (15 to 30 milliliters) of water into a cup containing the granules. Mix the contents and then immediately take the mixture by mouth from the cup or with an oral syringe; do not save the mixture for a later time. The granules will not completely dissolve. If any of the mixture remains, add 1 to 2 tablespoons (15 to 30 milliliters) of water to the mixture and immediately take it.

Swallow the extended-release capsules and extended-release tablets whole with water; do not split, chew, or crush them. Do not open the immediate-release capsules,

Your doctor will monitor you carefully and adjust your dose as needed. Talk to your doctor often about how you are feeling during your treatment. Ask your doctor if you have any questions about how much tacrolimus you should take.

Different tacrolimus products release the medication differently in your body and cannot be used interchangeably. Only take the tacrolimus product prescribed by your doctor and do not switch to a different tacrolimus product unless your doctor says that you should.

Tacrolimus can only prevent rejection of your transplant as long as you are taking the medication. Continue to take tacrolimus even if you feel well. Do not stop taking tacrolimus without talking to your doctor.

Tacrolimus is also sometimes used to treat fistulizing Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, fever, and the formation of abnormal tunnels connecting the digestive tract to other organs or the skin). Talk to your doctor about the risks of using this medication to treat your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking tacrolimus,

• tell your doctor and pharmacist if you are allergic to tacrolimus, any other medications, or any of the other ingredients in tacrolimus products. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone); amphotericin B (Abelcet, Ambisome); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Prinzide, in Zestoretic), moexipril (Univasc, in Uniretic), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), or trandolapril (in Tarka); antacids containing magnesium and aluminum hydroxide (Maalox); certain antibiotics including aminoglycosides such as amikacin, gentamicin, neomycin (Neo-Fradin), streptomycin, and tobramycin (Tobi), and macrolides such as clarithromycin (Biaxin), erythromycin (EES, E-Mycin, Erythrocin), and troleandomycin (TAO; not available in the US); antifungal medications such as clotrimazole (Lotrimin, Mycelex), fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), and voriconazole (Vfend); angiotensin receptor blockers (ARBs) such as azilsartan (Edarbi, in Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta); boceprevir (Victrelis; no longer available in U.S.); calcium channel blockers such as diltiazem (Cardizem), nicardipine , nifedipine (Adalat, Procardia), and verapamil (Calan, Verelan, in Tarka); caspofungin (Cancidas); chloramphenicol; cimetidine (Tagamet); cisapride (Propulsid; not available in the U.S.); cisplatin ; danazol; certain diuretics ('water pills'); ganciclovir (Valcyte); certain hormonal contraceptives (birth control pills, patches, rings, inserts, or injections); certain medications for HIV such as didanosine (Videx); indinavir (Crixivan), lamivudine (Epivir); nelfinavir (Viracept), ritonavir (Norvir), stavudine (Zerit), and zidovudine (Retrovir) lansoprazole (Prevacid); methylprednisolone (Medrol); metoclopramide (Reglan); mycophenolate (Cellcept); nefazodone; omeprazole (Prilosec); prednisone; rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); certain medications for seizures such as carbamazepine (Tegretol, Teril), phenobarbital, and phenytoin (Dilantin, Phenytek);sirolimus (Rapamune), and telaprevir (Incivek; no longer available in U.S.). Your doctor may need to change the doses of your medications or monitor you more carefully for side effects. Many other medications may also interact with tacrolimus, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

• tell your doctor if you are taking or have recently stopped taking cyclosporine (Gengraf, Neoral, Sandimmune). If you were taking cyclosporine, your doctor will probably tell you not to start taking tacrolimus until 24 hours after you took your last dose of cyclosporine. If you stop taking tacrolimus, your doctor will also tell you to wait 24 hours before starting to take cyclosporine.

• tell your doctor and pharmacist what herbal products you are taking, especially St. John's wort or schisandra sphenanthera extracts. Do not take these herbal products while taking tacrolimus.

• tell your doctor if you have or have ever had long QT syndrome (an inherited condition in which a person is more likely to have QT prolongation) low levels of potassium, calcium, or magnesium in your blood, an irregular heartbeat, high cholesterol levels, cystic fibrosis (an inborn disease that causes the body to produce thick, sticky mucus that may clog the pancreas, the lungs, and other parts of the body), heart, kidney, or liver disease.

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you or your partner are able to become pregnant, use effective birth control before and during treatment with tacrolimus. If you become pregnant while taking tacrolimus, call your doctor. Tacrolimus may harm the fetus.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking tacrolimus.

• you should know that taking tacrolimus may increase the risk that you will develop skin cancer. Protect yourself from skin cancer by avoiding unnecessary or prolonged exposure to sunlight or ultraviolet light (tanning beds) and wearing protective clothing, sunglasses, and sunscreen with a high skin protection factor (SPF).

• do not drink alcoholic beverages while you are taking tacrolimus extended-release capsules or extended-release tablets. Alcohol can make the side effects from tacrolimus worse.

• you should know that tacrolimus may cause high blood pressure. Your doctor will monitor your blood pressure carefully, and may prescribe medication to treat high blood pressure if it develops.

• you should know that there is a risk that you will develop diabetes during your treatment with tacrolimus. African American and Hispanic patients who have had kidney transplants have an especially high risk of developing diabetes during their treatment with tacrolimus. Tell your doctor if you or anyone in your family has or has ever had diabetes. If you experience any of the following symptoms, call your doctor immediately: excessive thirst; excessive hunger; frequent urination; blurred vision or confusion.

• do not have any vaccinations without talking to your doctor.

Avoid eating grapefruit or drinking grapefruit juice while taking tacrolimus.

If the immediate-release capsule or oral suspension dose is missed, take it as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

If the extended-release capsule dose is missed, take the dose if it is within 14 hours after missing the dose. However, if it is more than 14 hours, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

If the extended-release tablet dose is missed, take the dose it if it is within 15 hours after missing the dose. However, if it is more than 15 hours, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Tacrolimus may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache

  • diarrhea

  • constipation

  • nausea

  • vomiting

  • heartburn

  • stomach pain

  • loss of appetite

  • difficulty falling asleep or staying asleep

  • dizziness

  • weakness

  • back or joint pain

  • burning, numbness, pain, or tingling in the hands or feet

• Some side effects can be serious. If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately:

  • decreased urination

  • pain or burning on urination

  • shortness of breath, hives, rash, or itching

  • pale skin, shortness of breath, or fast heartbeat

  • tiredness; weight gain; swelling of the arms, hands, feet, ankles, or lower legs; or shortness of breath

  • unusual bleeding or bruising

  • seizures, vision changes, headache, confusion, or uncontrollable shaking of a part of the body

  • coma (loss of consciousness for a period of time)

• Tacrolimus may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• hives

• sleepiness

• nausea, vomiting, and diarrhea

• uncontrollable shaking of a part of the body, headache, confusion, imbalance, and extreme tiredness

• swelling of arms or legs

• fever or other signs of infection

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during your treatment to check your body's response to tacrolimus.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

• FK 506

Drug	Interaction
Moxifloxacin	Moxifloxacin The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Moxifloxacin.
Candesartan	Candesartan The risk or severity of hyperkalemia can be increased when Tacrolimus is combined with Candesartan.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Tacrolimus.
Penbutolol	Penbutolol The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Acebutolol.
Triamcinolone	Triamcinolone Tacrolimus may increase the immunosuppressive activities of Triamcinolone.
Pamidronate Injection	Pamidronate Injection The risk or severity of nephrotoxicity and hypocalcemia can be increased when Tacrolimus is combined with Pamidronic acid.
Vancomycin Injection	Vancomycin Injection Tacrolimus may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection	Zidovudine Injection Tacrolimus may increase the immunosuppressive activities of Zidovudine.
Cefuroxime	Cefuroxime The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Cefuroxime.
Sevelamer	Sevelamer The serum concentration of Tacrolimus can be decreased when it is combined with Sevelamer.
Linezolid	Linezolid Tacrolimus may increase the immunosuppressive activities of Linezolid.
Pentosan Polysulfate	Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Tacrolimus.
Trimipramine	Trimipramine The serum concentration of Tacrolimus can be increased when it is combined with Trimipramine.
Etanercept Injection	Etanercept Injection Tacrolimus may increase the immunosuppressive activities of Etanercept.
Tenofovir	Tenofovir Tenofovir may increase the nephrotoxic activities of Tacrolimus.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate The risk or severity of renal failure can be increased when Choline magnesium trisalicylate is combined with Tacrolimus.
Dutasteride	Dutasteride The metabolism of Tacrolimus can be decreased when combined with Dutasteride.
Glatiramer Injection	Glatiramer Injection Tacrolimus may increase the immunosuppressive activities of Glatiramer.
Alfuzosin	Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Tacrolimus.
Tegaserod	Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Tacrolimus.
Gemifloxacin	Gemifloxacin The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Gemifloxacin.
Apomorphine Injection	Apomorphine Injection The metabolism of Tacrolimus can be decreased when combined with Apomorphine.
Infliximab Injection	Infliximab Injection Tacrolimus may increase the immunosuppressive activities of Infliximab.
Tinidazole	Tinidazole Tacrolimus may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Palifermin	Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Tacrolimus.
Voriconazole	Voriconazole The serum concentration of Tacrolimus can be increased when it is combined with Voriconazole.
Adefovir	Adefovir The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Adefovir.
Peginterferon Alfa-2a Injection	Peginterferon Alfa-2a Injection Tacrolimus may increase the immunosuppressive activities of Peginterferon alfa-2a.
Pramlintide Injection	Pramlintide Injection The therapeutic efficacy of Pramlintide can be decreased when used in combination with Tacrolimus.
Ibandronate	Ibandronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Tacrolimus is combined with Ibandronate.
Pregabalin	Pregabalin The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Tacrolimus.
Tipranavir	Tipranavir The serum concentration of Tacrolimus can be increased when it is combined with Tipranavir.
Insulin Detemir (rDNA Origin) Injection	Insulin Detemir (rDNA Origin) Injection The therapeutic efficacy of Insulin detemir can be decreased when used in combination with Tacrolimus.
Rasagiline	Rasagiline Tacrolimus may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Live Shingles (Zoster) Vaccine (ZVL)	Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Tacrolimus.
Rituximab Injection	Rituximab Injection Tacrolimus may increase the immunosuppressive activities of Rituximab.
Vorinostat	Vorinostat Tacrolimus may increase the immunosuppressive activities of Vorinostat.
Azacitidine Injection	Azacitidine Injection Tacrolimus may increase the immunosuppressive activities of Azacitidine.
Bexarotene	Bexarotene Tacrolimus may increase the immunosuppressive activities of Bexarotene.
Budesonide	Budesonide Tacrolimus may increase the immunosuppressive activities of Budesonide.
Chloramphenicol Injection	Chloramphenicol Injection The serum concentration of Tacrolimus can be increased when it is combined with Chloramphenicol.
Decitabine Injection	Decitabine Injection Tacrolimus may increase the immunosuppressive activities of Decitabine.
Doripenem Injection	Doripenem Injection Tacrolimus may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection	Arsenic Trioxide Injection Tacrolimus may increase the immunosuppressive activities of Arsenic trioxide.
Tretinoin	Tretinoin Tacrolimus may increase the immunosuppressive activities of Tretinoin.
Bendamustine Injection	Bendamustine Injection Tacrolimus may increase the immunosuppressive activities of Bendamustine.
Daptomycin Injection	Daptomycin Injection Tacrolimus may decrease the excretion rate of Daptomycin which could result in a higher serum level.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia)	Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Tacrolimus may increase the immunosuppressive activities of Alemtuzumab.
Betaxolol	Betaxolol The risk or severity of QTc prolongation can be increased when Betaxolol is combined with Tacrolimus.
Everolimus	Everolimus Tacrolimus may increase the immunosuppressive activities of Everolimus.
Dronedarone	Dronedarone The serum concentration of Dronedarone can be increased when it is combined with Tacrolimus.
Dabigatran	Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Tacrolimus.
Fingolimod	Fingolimod Tacrolimus may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection	Eribulin Injection Tacrolimus may increase the immunosuppressive activities of Eribulin.
Ceftaroline Injection	Ceftaroline Injection The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Ceftaroline fosamil.
Lurasidone	Lurasidone The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Lurasidone.
Acetaminophen Injection	Acetaminophen Injection The serum concentration of Tacrolimus can be increased when it is combined with Acetaminophen.
Ipilimumab Injection	Ipilimumab Injection Tacrolimus may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Terbutaline Injection	Terbutaline Injection Tacrolimus may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Belimumab Injection	Belimumab Injection Tacrolimus may increase the immunosuppressive activities of Belimumab.
Azilsartan	Azilsartan The risk or severity of hyperkalemia can be increased when Tacrolimus is combined with Azilsartan medoxomil.
Busulfan Injection	Busulfan Injection Tacrolimus may increase the immunosuppressive activities of Busulfan.
Roflumilast	Roflumilast Roflumilast may increase the immunosuppressive activities of Tacrolimus.
Linagliptin	Linagliptin The serum concentration of Tacrolimus can be increased when it is combined with Linagliptin.
Rilpivirine	Rilpivirine The serum concentration of Tacrolimus can be increased when it is combined with Rilpivirine.
Telaprevir	Telaprevir The metabolism of Glecaprevir can be decreased when combined with Tacrolimus.
Rivaroxaban	Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Tacrolimus.
Ticagrelor	Ticagrelor The serum concentration of Tacrolimus can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The serum concentration of Tacrolimus can be increased when it is combined with Brentuximab vedotin.
Ruxolitinib	Ruxolitinib Tacrolimus may increase the immunosuppressive activities of Ruxolitinib.
Vandetanib	Vandetanib The metabolism of Vandetanib can be decreased when combined with Tacrolimus.
Clobazam	Clobazam The metabolism of Clobazam can be increased when combined with Tacrolimus.
Vemurafenib	Vemurafenib The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Vemurafenib.
Belatacept Injection	Belatacept Injection Tacrolimus may increase the immunosuppressive activities of Belatacept.
Ivacaftor	Ivacaftor The serum concentration of Tacrolimus can be increased when it is combined with Ivacaftor.
Basiliximab Injection	Basiliximab Injection Tacrolimus may increase the immunosuppressive activities of Basiliximab.
Deferiprone	Deferiprone Tacrolimus may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib	Axitinib The metabolism of Tacrolimus can be decreased when combined with Axitinib.
Crizotinib	Crizotinib The serum concentration of Tacrolimus can be increased when it is combined with Crizotinib.
Carfilzomib Injection	Carfilzomib Injection Tacrolimus may increase the immunosuppressive activities of Carfilzomib.
Enzalutamide	Enzalutamide The metabolism of Tacrolimus can be increased when combined with Enzalutamide.
Mirabegron	Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Tacrolimus.
Regorafenib	Regorafenib The serum concentration of Tacrolimus can be increased when it is combined with Regorafenib.
Bosutinib	Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Tacrolimus.
Teriflunomide	Teriflunomide Tacrolimus may increase the immunosuppressive activities of Teriflunomide.
Teduglutide Injection	Teduglutide Injection Tacrolimus may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Bedaquiline	Bedaquiline The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Bedaquiline.
Icosapent Ethyl	Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Tacrolimus.
Tofacitinib	Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Tacrolimus.
Alogliptin	Alogliptin Tacrolimus may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Dimethyl Fumarate	Dimethyl Fumarate Tacrolimus may increase the immunosuppressive activities of Dimethyl fumarate.
Ponatinib	Ponatinib Tacrolimus may increase the immunosuppressive activities of Ponatinib.
Pomalidomide	Pomalidomide Tacrolimus may increase the immunosuppressive activities of Pomalidomide.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The serum concentration of Tacrolimus can be increased when it is combined with Trastuzumab emtansine.
Apixaban	Apixaban The metabolism of Tacrolimus can be decreased when combined with Apixaban.
Canagliflozin	Canagliflozin The serum concentration of Canagliflozin can be increased when it is combined with Tacrolimus.
Dabrafenib	Dabrafenib The metabolism of Tacrolimus can be increased when combined with Dabrafenib.
Trametinib	Trametinib The metabolism of Tacrolimus can be increased when combined with Trametinib.
Dolutegravir	Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Tacrolimus.
Afatinib	Afatinib The serum concentration of Afatinib can be increased when it is combined with Tacrolimus.
Levomilnacipran	Levomilnacipran Tacrolimus may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
Vortioxetine	Vortioxetine The metabolism of Tacrolimus can be decreased when combined with Vortioxetine.
Perampanel	Perampanel The metabolism of Tacrolimus can be increased when combined with Perampanel.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Tacrolimus.
Lomitapide	Lomitapide The serum concentration of Tacrolimus can be increased when it is combined with Lomitapide.
Simeprevir	Simeprevir The serum concentration of Tacrolimus can be increased when it is combined with Simeprevir.
Sofosbuvir	Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Tacrolimus.
Dapagliflozin	Dapagliflozin The therapeutic efficacy of Dapagliflozin can be decreased when used in combination with Tacrolimus.
Apremilast	Apremilast Tacrolimus may increase the immunosuppressive activities of Apremilast.
Droxidopa	Droxidopa Tacrolimus may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib	Ceritinib The serum concentration of Tacrolimus can be increased when it is combined with Ceritinib.
Siltuximab Injection	Siltuximab Injection The serum concentration of Tacrolimus can be increased when it is combined with Siltuximab.
Albiglutide Injection	Albiglutide Injection The therapeutic efficacy of Albiglutide can be decreased when used in combination with Tacrolimus.
Eslicarbazepine	Eslicarbazepine The metabolism of Tacrolimus can be increased when combined with Eslicarbazepine.
Vedolizumab Injection	Vedolizumab Injection Tacrolimus may increase the immunosuppressive activities of Vedolizumab.
Belinostat Injection	Belinostat Injection Tacrolimus may increase the immunosuppressive activities of Belinostat.
Idelalisib	Idelalisib The serum concentration of Tacrolimus can be increased when it is combined with Idelalisib.
Testosterone Injection	Testosterone Injection The metabolism of Tacrolimus can be increased when combined with Testosterone.
Oritavancin Injection	Oritavancin Injection The metabolism of Tacrolimus can be increased when combined with Oritavancin.
Empagliflozin	Empagliflozin The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Tacrolimus.
Vorapaxar	Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Tacrolimus.
Suvorexant	Suvorexant The metabolism of Suvorexant can be decreased when combined with Tacrolimus.
Dulaglutide Injection	Dulaglutide Injection The therapeutic efficacy of Dulaglutide can be decreased when used in combination with Tacrolimus.
Edoxaban	Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Tacrolimus.
Peginterferon Beta-1a Injection	Peginterferon Beta-1a Injection Tacrolimus may increase the immunosuppressive activities of Peginterferon beta-1a.
Olaparib	Olaparib The serum concentration of Tacrolimus can be increased when it is combined with Olaparib.
Blinatumomab Injection	Blinatumomab Injection Tacrolimus may increase the immunosuppressive activities of Blinatumomab.
Caspofungin Injection	Caspofungin Injection The serum concentration of Tacrolimus can be decreased when it is combined with Caspofungin.
Tasimelteon	Tasimelteon The metabolism of Tacrolimus can be decreased when combined with Tasimelteon.
Pirfenidone	Pirfenidone Tacrolimus may increase the immunosuppressive activities of Pirfenidone.
Nintedanib	Nintedanib The metabolism of Tacrolimus can be decreased when combined with Nintedanib.
Secukinumab Injection	Secukinumab Injection Tacrolimus may increase the immunosuppressive activities of Secukinumab.
Palbociclib	Palbociclib The serum concentration of Tacrolimus can be increased when it is combined with Palbociclib.
Lenvatinib	Lenvatinib The serum concentration of Tacrolimus can be increased when it is combined with Lenvatinib.
Naloxegol	Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Tacrolimus.
Panobinostat	Panobinostat Tacrolimus may increase the immunosuppressive activities of Panobinostat.
Dinutuximab Injection	Dinutuximab Injection Tacrolimus may increase the immunosuppressive activities of Dinutuximab.
Ivabradine	Ivabradine The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Ivabradine.
Isavuconazonium Injection	Isavuconazonium Injection The serum concentration of Tacrolimus can be increased when it is combined with Isavuconazonium.
Macitentan	Macitentan Tacrolimus may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sonidegib	Sonidegib The metabolism of Sonidegib can be decreased when combined with Tacrolimus.
Daclatasvir	Daclatasvir The metabolism of Tacrolimus can be decreased when combined with Daclatasvir.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Tacrolimus.
Eluxadoline	Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Tacrolimus.
Insulin Degludec (rDNA Origin) Injection	Insulin Degludec (rDNA Origin) Injection The therapeutic efficacy of Insulin degludec can be decreased when used in combination with Tacrolimus.
Cobimetinib	Cobimetinib The serum concentration of Tacrolimus can be increased when it is combined with Cobimetinib.
Mepolizumab Injection	Mepolizumab Injection Tacrolimus may increase the immunosuppressive activities of Mepolizumab.
Trabectedin Injection	Trabectedin Injection Tacrolimus may increase the immunosuppressive activities of Trabectedin.
Osimertinib	Osimertinib The serum concentration of Tacrolimus can be increased when it is combined with Osimertinib.
Alectinib	Alectinib The metabolism of Alectinib can be decreased when combined with Tacrolimus.
Ixazomib	Ixazomib The metabolism of Ixazomib can be decreased when combined with Tacrolimus.
Lesinurad	Lesinurad The metabolism of Lesinurad can be increased when combined with Tacrolimus.
Defibrotide Injection	Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Tacrolimus.
Ixekizumab Injection	Ixekizumab Injection Tacrolimus may increase the immunosuppressive activities of Ixekizumab.
Brivaracetam Injection	Brivaracetam Injection Tacrolimus may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Venetoclax	Venetoclax The serum concentration of Tacrolimus can be increased when it is combined with Venetoclax.
Cobicistat	Cobicistat The serum concentration of Tacrolimus can be increased when it is combined with Cobicistat.
Selexipag	Selexipag The serum concentration of Selexipag can be increased when it is combined with Tacrolimus.
Rucaparib	Rucaparib The serum concentration of Tacrolimus can be increased when it is combined with Rucaparib.
Lixisenatide Injection	Lixisenatide Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Tacrolimus.
Ribociclib	Ribociclib The serum concentration of Tacrolimus can be increased when it is combined with Ribociclib.
Brodalumab Injection	Brodalumab Injection Tacrolimus may increase the immunosuppressive activities of Brodalumab.
Brigatinib	Brigatinib The metabolism of Tacrolimus can be increased when combined with Brigatinib.
Deutetrabenazine	Deutetrabenazine The metabolism of Tacrolimus can be decreased when combined with Deutetrabenazine.
Valbenazine	Valbenazine The metabolism of Tacrolimus can be decreased when combined with Valbenazine.
Deflazacort	Deflazacort Tacrolimus may increase the immunosuppressive activities of Deflazacort.
Safinamide	Safinamide The metabolism of Tacrolimus can be decreased when combined with Safinamide.
Ocrelizumab Injection	Ocrelizumab Injection Ocrelizumab may increase the immunosuppressive activities of Tacrolimus.
Naldemedine	Naldemedine Tacrolimus may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Sarilumab Injection	Sarilumab Injection The serum concentration of Tacrolimus can be increased when it is combined with Sarilumab.
Midostaurin	Midostaurin The serum concentration of Tacrolimus can be increased when it is combined with Midostaurin.
Neratinib	Neratinib The metabolism of Neratinib can be decreased when combined with Tacrolimus.
Guselkumab Injection	Guselkumab Injection Tacrolimus may increase the immunosuppressive activities of Guselkumab.
Enasidenib	Enasidenib The serum concentration of Tacrolimus can be increased when it is combined with Enasidenib.
Inotuzumab Ozogamicin Injection	Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Tacrolimus.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The serum concentration of Tacrolimus can be increased when it is combined with Fosaprepitant.
Benznidazole	Benznidazole Tacrolimus may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection	Copanlisib Injection The metabolism of Tacrolimus can be decreased when combined with Copanlisib.
Delafloxacin	Delafloxacin Tacrolimus may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib	Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Tacrolimus.
Betrixaban	Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Tacrolimus.
Acalabrutinib	Acalabrutinib The serum concentration of Tacrolimus can be increased when it is combined with Acalabrutinib.
Gemtuzumab Ozogamicin Injection	Gemtuzumab Ozogamicin Injection Tacrolimus may increase the immunosuppressive activities of Gemtuzumab ozogamicin.
Letermovir	Letermovir The serum concentration of Tacrolimus can be increased when it is combined with Letermovir.
Semaglutide Injection	Semaglutide Injection The therapeutic efficacy of Semaglutide can be decreased when used in combination with Tacrolimus.
Tetrabenazine	Tetrabenazine The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Tetrabenazine.
Ertugliflozin	Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Tacrolimus.
Buprenorphine Injection	Buprenorphine Injection The serum concentration of Tacrolimus can be increased when it is combined with Buprenorphine.
Apalutamide	Apalutamide The metabolism of Tacrolimus can be increased when combined with Apalutamide.
Fostamatinib	Fostamatinib The serum concentration of Tacrolimus can be increased when it is combined with Fostamatinib.
Avatrombopag	Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Tacrolimus.
Baricitinib	Baricitinib Tacrolimus may increase the immunosuppressive activities of Baricitinib.
Plazomicin Injection	Plazomicin Injection Tacrolimus may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat	Eliglustat The metabolism of Eliglustat can be decreased when combined with Tacrolimus.
Encorafenib	Encorafenib The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Encorafenib.
Binimetinib	Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Tacrolimus.
Ivosidenib	Ivosidenib The metabolism of Ivosidenib can be increased when combined with Tacrolimus.
Lusutrombopag	Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Tacrolimus.
Elagolix	Elagolix The serum concentration of Elagolix can be increased when it is combined with Tacrolimus.
Doravirine	Doravirine The metabolism of Tacrolimus can be decreased when combined with Doravirine.
Cannabidiol	Cannabidiol The metabolism of Tacrolimus can be decreased when combined with Cannabidiol.
Dacomitinib	Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Tacrolimus.
Duvelisib	Duvelisib The metabolism of Tacrolimus can be decreased when combined with Duvelisib.
Omadacycline	Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Tacrolimus.
Stiripentol	Stiripentol The serum concentration of Tacrolimus can be increased when it is combined with Stiripentol.
Talazoparib	Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Tacrolimus.
Gilteritinib	Gilteritinib The metabolism of Tacrolimus can be decreased when combined with Gilteritinib.
Glasdegib	Glasdegib The serum concentration of Glasdegib can be increased when it is combined with Tacrolimus.
Lorlatinib	Lorlatinib The metabolism of Tacrolimus can be decreased when combined with Lorlatinib.
Larotrectinib	Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Tacrolimus.
Prucalopride	Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Tacrolimus.
Ravulizumab-cwvz Injection	Ravulizumab-cwvz Injection Tacrolimus may increase the immunosuppressive activities of Ravulizumab.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection Tacrolimus may increase the immunosuppressive activities of Emapalumab.
Siponimod	Siponimod Tacrolimus may increase the immunosuppressive activities of Siponimod.
Caplacizumab-yhdp Injection	Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Tacrolimus.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Tacrolimus.
Risankizumab-rzaa Injection	Risankizumab-rzaa Injection Tacrolimus may increase the immunosuppressive activities of Risankizumab.
Alpelisib	Alpelisib The serum concentration of Tacrolimus can be increased when it is combined with Alpelisib.
Solriamfetol	Solriamfetol Tacrolimus may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Darolutamide	Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Tacrolimus.
Triclabendazole	Triclabendazole The serum concentration of Tacrolimus can be increased when it is combined with Triclabendazole.
Entrectinib	Entrectinib The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Entrectinib.
Pexidartinib	Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Tacrolimus.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Tacrolimus.
Pitolisant	Pitolisant The serum concentration of Tacrolimus can be decreased when it is combined with Pitolisant.
Fedratinib	Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Tacrolimus.
Lefamulin	Lefamulin Tacrolimus may increase the QTc-prolonging activities of Lefamulin.
Enfortumab vedotin-ejfv Injection	Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Tacrolimus.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Tacrolimus.
Voxelotor	Voxelotor The serum concentration of Tacrolimus can be increased when it is combined with Voxelotor.
Lasmiditan	Lasmiditan The serum concentration of Lasmiditan can be increased when it is combined with Tacrolimus.
Ubrogepant	Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Tacrolimus.
Tazemetostat	Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Tacrolimus.
Cenobamate	Cenobamate The serum concentration of Tacrolimus can be increased when it is combined with Cenobamate.
Ozanimod	Ozanimod Tacrolimus may increase the immunosuppressive activities of Ozanimod.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Tacrolimus.
Rimegepant	Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Tacrolimus.
Remdesivir Injection	Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Tacrolimus.
Lemborexant	Lemborexant The metabolism of Lemborexant can be decreased when combined with Tacrolimus.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Tacrolimus can be decreased when combined with Drospirenone.
Viloxazine	Viloxazine Tacrolimus may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Tacrolimus which could result in a higher serum level.
Theophylline	Theophylline The metabolism of Theophylline can be decreased when combined with Tacrolimus.
Tolmetin	Tolmetin The risk or severity of renal failure can be increased when Tolmetin is combined with Tacrolimus.
Sulindac	Sulindac The risk or severity of renal failure can be increased when Sulindac is combined with Tacrolimus.
Trazodone	Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Tacrolimus.
Sucralfate	Sucralfate Tacrolimus may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Clorazepate	Clorazepate Tacrolimus may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Carmustine	Carmustine Tacrolimus may increase the immunosuppressive activities of Carmustine.
Bromocriptine	Bromocriptine The serum concentration of Tacrolimus can be increased when it is combined with Bromocriptine.
Tranylcypromine	Tranylcypromine The serum concentration of Tacrolimus can be increased when it is combined with Tranylcypromine.
Tetracycline	Tetracycline The serum concentration of Tacrolimus can be increased when it is combined with Tetracycline.
Thioguanine	Thioguanine Tacrolimus may increase the immunosuppressive activities of Tioguanine.
Thioridazine	Thioridazine The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Thioridazine.
Bleomycin	Bleomycin Tacrolimus may increase the immunosuppressive activities of Bleomycin.
Sulfadiazine	Sulfadiazine Tacrolimus may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Benztropine	Benztropine Tacrolimus may decrease the excretion rate of Benzatropine which could result in a higher serum level.
Azathioprine	Azathioprine Tacrolimus may increase the immunosuppressive activities of Azathioprine.
Carbamazepine	Carbamazepine Tacrolimus may increase the immunosuppressive activities of Carbamazepine.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Tacrolimus which could result in a higher serum level.
Warfarin	Warfarin The serum concentration of Warfarin can be increased when it is combined with Tacrolimus.
Calcitriol	Calcitriol The metabolism of Tacrolimus can be increased when combined with Calcitriol.
Triamterene	Triamterene The risk or severity of hyperkalemia can be increased when Triamterene is combined with Tacrolimus.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Tacrolimus can be increased when combined with Sulfinpyrazone.
Valproic Acid	Valproic Acid The serum concentration of Tacrolimus can be increased when it is combined with Valproic acid.
Tamoxifen	Tamoxifen The serum concentration of Tacrolimus can be increased when it is combined with Tamoxifen.
Liothyronine	Liothyronine Tacrolimus may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Tolbutamide	Tolbutamide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Tacrolimus.
Tolazamide	Tolazamide The therapeutic efficacy of Tolazamide can be decreased when used in combination with Tacrolimus.
Baclofen	Baclofen Tacrolimus may decrease the excretion rate of Baclofen which could result in a higher serum level.
Brompheniramine	Brompheniramine The risk or severity of QTc prolongation can be increased when Dexbrompheniramine is combined with Tacrolimus.
Mercaptopurine	Mercaptopurine Tacrolimus may increase the immunosuppressive activities of Mercaptopurine.
Cefaclor	Cefaclor Tacrolimus may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Cefadroxil	Cefadroxil Tacrolimus may decrease the excretion rate of Cefadroxil which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Cefazolin.
Cephalexin	Cephalexin The metabolism of Tacrolimus can be decreased when combined with Cephalexin.
Cefoxitin Injection	Cefoxitin Injection The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Cefoxitin.
Acetazolamide	Acetazolamide The serum concentration of Tacrolimus can be increased when it is combined with Acetazolamide.
Cefotaxime Injection	Cefotaxime Injection The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Tacrolimus.
Bacillus Calmette-Guerin (BCG) Vaccine	Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Tacrolimus.
Thiotepa Injection	Thiotepa Injection Tacrolimus may increase the immunosuppressive activities of Thiotepa.
Vincristine Injection	Vincristine Injection Tacrolimus may increase the immunosuppressive activities of Vincristine.
Captopril	Captopril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Tacrolimus is combined with Captopril.
Vinblastine	Vinblastine The serum concentration of Tacrolimus can be increased when it is combined with Vinblastine.
Thiothixene	Thiothixene The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Thiothixene.
Aspirin	Aspirin The risk or severity of renal failure can be increased when Acetylsalicylic acid is combined with Tacrolimus.
Chlorambucil	Chlorambucil Tacrolimus may increase the immunosuppressive activities of Chlorambucil.
Temazepam	Temazepam Tacrolimus may decrease the excretion rate of Temazepam which could result in a higher serum level.
Triazolam	Triazolam The metabolism of Triazolam can be decreased when combined with Tacrolimus.
Hyoscyamine	Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Tacrolimus.
Trimethoprim	Trimethoprim Tacrolimus may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Timolol	Timolol Tacrolimus may decrease the excretion rate of Timolol which could result in a higher serum level.
Verapamil	Verapamil The serum concentration of Tacrolimus can be increased when it is combined with Verapamil.
Atenolol	Atenolol The risk or severity of hyperkalemia can be increased when Atenolol is combined with Tacrolimus.
Bumetanide	Bumetanide Tacrolimus may decrease the excretion rate of Bumetanide which could result in a higher serum level.
Streptozocin	Streptozocin Tacrolimus may increase the immunosuppressive activities of Streptozocin.
Ceftriaxone Injection	Ceftriaxone Injection Tacrolimus may decrease the excretion rate of Ceftriaxone which could result in a higher serum level.
Auranofin	Auranofin Tacrolimus may decrease the excretion rate of Auranofin which could result in a higher serum level.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Tacrolimus.
Ceftazidime Injection	Ceftazidime Injection Tacrolimus may decrease the excretion rate of Ceftazidime which could result in a higher serum level.
Cefotetan Injection	Cefotetan Injection Tacrolimus may decrease the excretion rate of Cefotetan which could result in a higher serum level.
Aztreonam Injection	Aztreonam Injection Tacrolimus may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone	Buspirone The metabolism of Tacrolimus can be decreased when combined with Buspirone.
Clarithromycin	Clarithromycin The serum concentration of Tacrolimus can be increased when it is combined with Clarithromycin.
Benazepril	Benazepril The risk or severity of hyperkalemia can be increased when Benazepril is combined with Tacrolimus.
Amlodipine	Amlodipine Amlodipine may increase the immunosuppressive activities of Tacrolimus.
Teniposide Injection	Teniposide Injection The serum concentration of Tacrolimus can be increased when it is combined with Teniposide.
Bisoprolol	Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Tacrolimus.
Tramadol	Tramadol The metabolism of Tacrolimus can be decreased when combined with Tramadol.
Lansoprazole	Lansoprazole The serum concentration of Tacrolimus can be increased when it is combined with Lansoprazole.
Ticlopidine	Ticlopidine The metabolism of Tacrolimus can be decreased when combined with Ticlopidine.
Acarbose	Acarbose The therapeutic efficacy of Acarbose can be decreased when used in combination with Tacrolimus.
Gemcitabine Injection	Gemcitabine Injection Tacrolimus may increase the immunosuppressive activities of Gemcitabine.
Indinavir	Indinavir The serum concentration of Tacrolimus can be increased when it is combined with Indinavir.
Zafirlukast	Zafirlukast The serum concentration of Tacrolimus can be increased when it is combined with Zafirlukast.
Mirtazapine	Mirtazapine The serum concentration of Tacrolimus can be increased when it is combined with Mirtazapine.
Nelfinavir	Nelfinavir The serum concentration of Tacrolimus can be increased when it is combined with Nelfinavir.
Azithromycin	Azithromycin The serum concentration of Tacrolimus can be increased when it is combined with Azithromycin.
Carvedilol	Carvedilol Carvedilol may increase the immunosuppressive activities of Tacrolimus.
Cefepime Injection	Cefepime Injection The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Cefepime.
Cefprozil	Cefprozil The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Cefprozil.
Cefpodoxime	Cefpodoxime The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Cefpodoxime.
Cetirizine	Cetirizine Tacrolimus may decrease the excretion rate of Cetirizine which could result in a higher serum level.
Capecitabine	Capecitabine Tacrolimus may increase the immunosuppressive activities of Capecitabine.
Efavirenz	Efavirenz The serum concentration of Tacrolimus can be increased when it is combined with Efavirenz.
Abacavir	Abacavir Tacrolimus may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil	Sildenafil The metabolism of Sildenafil can be decreased when combined with Tacrolimus.
Trastuzumab Injection	Trastuzumab Injection Tacrolimus may increase the immunosuppressive activities of Trastuzumab.
Celecoxib	Celecoxib The risk or severity of renal failure can be increased when Celecoxib is combined with Tacrolimus.
Tolterodine	Tolterodine Tacrolimus may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Thalidomide	Thalidomide Tacrolimus may increase the immunosuppressive activities of Thalidomide.
Balsalazide	Balsalazide The risk or severity of renal failure can be increased when Balsalazide is combined with Tacrolimus.
Rabeprazole	Rabeprazole The metabolism of Tacrolimus can be decreased when combined with Rabeprazole.