Siponimod

Generic name: Pronounced as (si pon' i mod)
Brand names
  • Mayzent®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 06/15/2021

Siponimod is used to prevent episodes of symptoms and slow the worsening of disability in adults with relapsing-remitting forms (course of disease where symptoms flare up from time to time) of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control). Siponimod is in a class of medications called sphingosine l-phosphate receptor modulators. It works by decreasing the action of immune cells that may cause nerve damage.

Siponimod comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take siponimod at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take siponimod exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

Your doctor will probably start you on a low dose of siponimod and gradually increase your dose for the first 4 or 5 days,

Siponimod may cause the heartbeat to slow, especially during the first 6 hours after you take your first dose. You will receive an electrocardiogram (ECG; test that records the electrical activity of the heart) before you take your first dose and again 6 hours after you take the dose. You will take your first dose of siponimod in your doctor's office or another medical facility. You will need to stay at the medical facility for at least 6 hours after you take the medication so that you can be monitored. You may need to stay at the medical facility for longer than 6 hours or overnight if you have certain conditions or take certain medications that increase the risk that your heartbeat will slow or if your heartbeat slows more than expected or continues to slow after the first 6 hours. You may also need to stay at a medical facility for at least 6 hours after you take your second dose if your heartbeat slows too much when you take your first dose. Tell your doctor if you experience dizziness, tiredness, chest pain, or slow or irregular heartbeat at any time during your treatment.

Siponimod may help control multiple sclerosis but will not cure it. Do not stop taking siponimod without talking to your doctor.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with siponimod and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking siponimod,

  • tell your doctor and pharmacist if you are allergic to siponimod any other medications, or any of the ingredients in siponimod tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: alemtuzumab (Campath, Lemtrada); amiodarone (Nexterone, Pacerone); beta-blockers such as atenolol (Tenormin, in Tenoretic), carteolol, labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, in Dutoprol, in Lopressor HCT), nadolol (Corgard, in Corzide), nebivolol (Bystolic, in Byvalson), propranolol (Inderal LA, Innopran XL), and timolol; carbamazepine (Carbatrol, Equetro, Tegretol, others); digoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, others); efavirenz (Sustiva, in Atripla, in Symfi); fluconazole (Diflucan); ivabradine (Corlanor); modafinil (Provigil); procainamide; quinidine (in Nuedexta); rifampin (Rifadin, Rimactane, in Rifamate, others); sotalol (Betapace, Sorine, Sotylize); and verapamil (Calan, Verelan, in Tarka). Also tell you doctor if you are taking any of the following medications, or if you have taken them in the past: corticosteroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); medications for cancer; and medications to weaken or control the immune system such as glatiramer acetate (Copaxone, Glatopa) and interferon beta (Betaseron, Extavia, Plegridy). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with siponimod, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you have or have had any of these conditions in the last six months: heart attack, angina (chest pain), stroke or mini-stroke, or heart failure. Also tell your doctor if you have an irregular heart rhythm. Your doctor may tell you not to take siponimod.

  • tell your doctor if you have ever fainted, had a heart attack, stroke, or mini stroke; if you currently have a fever or other signs of infection or if you have an infection that comes and goes or that does not go away; and if you have or have ever had diabetes; sleep apnea (condition in which you briefly stop breathing many times during the night) or other breathing problems; high blood pressure; uveitis (inflammation of the eye) or other eye problems; a slow heartbeat; skin cancer, or heart or liver disease. Also tell your doctor if you have recently received a vaccine.

  • tell your doctor if you are pregnant or plan to become pregnant, or are breastfeeding. You should use birth control to prevent pregnancy during your treatment and for at least 10 days after your final dose. If you become pregnant while taking siponimod or within 10 days after your final dose, call your doctor.

  • do not have any vaccinations for 1 week before you begin your treatment with siponimod, during your treatment, or for 1 month after your final dose without talking to your doctor. Talk to your doctor about vaccinations that you may need to receive before beginning your treatment with siponimod.

  • tell your doctor if you have never had chicken pox and have not received the chicken pox vaccine. Your doctor may order a blood test to see if you have been exposed to chicken pox. You may need to receive the chicken pox vaccine and then wait 1 month before beginning your treatment with siponimod.

Unless your doctor tells you otherwise, continue your normal diet.

If you miss 1 or more doses of siponimod during the initial titration period, call your doctor as you will need to restart treatment. If you have certain heart conditions, you may need to be monitored by your doctor for at least 6 hours when you take your next dose.

If you miss 1 to 3 days of siponimod after the titration period (maintenance dose), take the missed tablet as soon as you remember and continue your treatment. If you miss taking 4 or more days in a row of siponimod after the titration period (maintenance dose), call your doctor as you will need to restart treatment. If you have certain heart conditions, you may need to be monitored by your doctor for at least 6 hours when you restart treatment.

  • Siponimod may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • weakness

    • pain in the arms, legs, hands, or feet

    • diarrhea

    • headache

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • slow heartbeat

    • sore throat, body aches, fever, chills, cough, and other signs of infection and during treatment and for up to 1 month after your treatment

    • headache, neck stiffness, fever, sensitivity to light, nausea, or confusion during treatment and for up to 1 month after your treatment

    • sudden severe headache, confusion, changes in vision, or seizures

    • blurriness, shadows, or a blind spot in the center of your vision; sensitivity to light; unusual color to your vision or other vision problems

    • weakness on one side of the body or clumsiness of the arms or legs that worsens over time; changes in your thinking, memory, or balance; confusion or personality changes; or loss of strength

    • new or worsening shortness of breath

    • nausea, vomiting, loss of appetite, abdominal pain, yellowing of skin or eyes, or dark urine

  • Siponimod may increase the risk of developing skin cancer. Talk to your doctor about the risks of taking this medication.

  • A sudden increase episodes of MS symptoms and worsening of disability may occur after you stop taking siponimod. Tell your doctor if your MS symptoms worsen after stopping siponimod.

  • Siponimod may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store unopened containers of this medication in the refrigerator. Opened blister packs and bottles may be stored at room temperature and away from excess heat and moisture (not in the bathroom) for 3 months. Do not refrigerate the tablets after opening.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • slowed or irregular heartbeat

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests, eye exams, and will monitor your blood pressure before and during your treatment to be sure that it is safe for you to begin taking or continue to take siponimod.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking siponimod.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Montelukast Montelukast The metabolism of Siponimod can be decreased when combined with Montelukast.
Leflunomide Leflunomide The risk or severity of adverse effects can be increased when Siponimod is combined with Leflunomide.
Delavirdine Delavirdine The risk or severity of adverse effects can be increased when Delavirdine is combined with Siponimod.
Nevirapine Nevirapine The metabolism of Siponimod can be decreased when combined with Nevirapine.
Aminophylline Aminophylline The metabolism of Siponimod can be decreased when combined with Aminophylline.
Candesartan Candesartan The metabolism of Candesartan can be decreased when combined with Siponimod.
Clopidogrel Clopidogrel The metabolism of Siponimod can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The risk or severity of adverse effects can be increased when Erythromycin is combined with Siponimod.
Fenofibrate Fenofibrate The metabolism of Siponimod can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine Siponimod may decrease the antihypertensive activities of Guanfacine.
Methylergonovine Methylergonovine The metabolism of Siponimod can be decreased when combined with Methylergometrine.
Mycophenolate Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Siponimod.
Naratriptan Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Siponimod.
Olsalazine Olsalazine The risk or severity of hypertension can be increased when Olsalazine is combined with Siponimod.
Penbutolol Penbutolol Siponimod may decrease the antihypertensive activities of Acebutolol.
Prednisone Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Siponimod.
Reserpine Reserpine Siponimod may decrease the antihypertensive activities of Reserpine.
Rizatriptan Rizatriptan The risk or severity of hypertension can be increased when Rizatriptan is combined with Siponimod.
Sumatriptan Sumatriptan The risk or severity of hypertension can be increased when Sumatriptan is combined with Siponimod.
Tacrolimus Tacrolimus Tacrolimus may increase the immunosuppressive activities of Siponimod.
Triamcinolone Triamcinolone The metabolism of Siponimod can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Siponimod.
Doxycycline Injection Doxycycline Injection The metabolism of Siponimod can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The risk or severity of adverse effects can be increased when Fluconazole is combined with Siponimod.
Hydromorphone Injection Hydromorphone Injection The metabolism of Siponimod can be decreased when combined with Hydromorphone.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Siponimod.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Siponimod.
Meperidine Injection Meperidine Injection The metabolism of Siponimod can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Siponimod can be increased when combined with Methylprednisolone.
Metronidazole Injection Metronidazole Injection The metabolism of Siponimod can be decreased when combined with Metronidazole.
Zidovudine Injection Zidovudine Injection The metabolism of Siponimod can be decreased when combined with Zidovudine.
Altretamine Altretamine The risk or severity of hypertension can be increased when Amphetamine is combined with Siponimod.
Cyclosporine Cyclosporine Siponimod may increase the immunosuppressive activities of Cyclosporine.
Ondansetron Ondansetron The metabolism of Siponimod can be decreased when combined with Ondansetron.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Siponimod.
Olanzapine Olanzapine The metabolism of Siponimod can be decreased when combined with Olanzapine.
Alosetron Alosetron The metabolism of Siponimod can be decreased when combined with Alosetron.
Dofetilide Dofetilide The metabolism of Siponimod can be decreased when combined with Dofetilide.
Eprosartan Eprosartan Siponimod may decrease the antihypertensive activities of Eprosartan.
Hydroxychloroquine Hydroxychloroquine The risk or severity of adverse effects can be increased when Hydroxychloroquine is combined with Siponimod.
Meloxicam Meloxicam The metabolism of Siponimod can be decreased when combined with Meloxicam.
Orlistat Orlistat The metabolism of Siponimod can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Siponimod can be increased when combined with Oxcarbazepine.
Telmisartan Telmisartan Siponimod may decrease the antihypertensive activities of Telmisartan.
Temozolomide Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Siponimod.
Anakinra Anakinra The metabolism of Siponimod can be increased when combined with Anakinra.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Siponimod.
Trimipramine Trimipramine The metabolism of Siponimod can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Siponimod can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Siponimod can be increased when combined with Modafinil.
Perindopril Perindopril Siponimod may decrease the antihypertensive activities of Perindopril.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Siponimod.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of hypertension can be increased when Choline magnesium trisalicylate is combined with Siponimod.
Sirolimus Sirolimus The risk or severity of adverse effects can be increased when Sirolimus is combined with Siponimod.
Dutasteride Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Siponimod.
Epinephrine Injection Epinephrine Injection The metabolism of Siponimod can be decreased when combined with Epinephrine.
Epirubicin Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Siponimod.
Eplerenone Eplerenone Siponimod may decrease the antihypertensive activities of Eplerenone.
Olmesartan Olmesartan Siponimod may decrease the antihypertensive activities of Olmesartan.
Adalimumab Injection Adalimumab Injection The metabolism of Siponimod can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Siponimod.
Atomoxetine Atomoxetine The risk or severity of hypertension can be increased when Atomoxetine is combined with Siponimod.
Dexmethylphenidate Dexmethylphenidate The risk or severity of hypertension can be increased when Dexmethylphenidate is combined with Siponimod.
Glatiramer Injection Glatiramer Injection The risk or severity of adverse effects can be increased when Glatiramer is combined with Siponimod.
Atazanavir Atazanavir The risk or severity of adverse effects can be increased when Atazanavir is combined with Siponimod.
Almotriptan Almotriptan The risk or severity of hypertension can be increased when Almotriptan is combined with Siponimod.
Eletriptan Eletriptan The metabolism of Siponimod can be decreased when combined with Eletriptan.
Mefloquine Mefloquine The metabolism of Siponimod can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Siponimod can be decreased when combined with Rosuvastatin.
Aprepitant Aprepitant The risk or severity of adverse effects can be increased when Aprepitant is combined with Siponimod.
Tadalafil Tadalafil Siponimod may decrease the antihypertensive activities of Tadalafil.
Frovatriptan Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Siponimod.
Progesterone Progesterone The metabolism of Siponimod can be increased when combined with Progesterone.
Infliximab Injection Infliximab Injection The metabolism of Siponimod can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Siponimod can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline The risk or severity of hypertension can be increased when Protriptyline is combined with Siponimod.
Rifaximin Rifaximin The therapeutic efficacy of Siponimod can be decreased when used in combination with Rifaximin.
Duloxetine Duloxetine The metabolism of Siponimod can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Siponimod can be decreased when combined with Norethisterone.
Bosentan Bosentan The therapeutic efficacy of Siponimod can be decreased when used in combination with Bosentan.
Natalizumab Injection Natalizumab Injection The risk or severity of adverse effects can be increased when Siponimod is combined with Natalizumab.
Erlotinib Erlotinib The metabolism of Siponimod can be decreased when combined with Erlotinib.
Solifenacin Solifenacin The risk or severity of hypertension can be increased when Solifenacin is combined with Siponimod.
Voriconazole Voriconazole The risk or severity of adverse effects can be increased when Voriconazole is combined with Siponimod.
Dextroamphetamine Dextroamphetamine The risk or severity of hypertension can be increased when Amphetamine is combined with Siponimod.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Siponimod.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Siponimod can be increased when combined with Peginterferon alfa-2b.
Isocarboxazid Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Siponimod.
Ramelteon Ramelteon The metabolism of Siponimod can be decreased when combined with Ramelteon.
Fentanyl Fentanyl The risk or severity of hypertension can be increased when Fentanyl is combined with Siponimod.
Deferasirox Deferasirox The metabolism of Siponimod can be increased when combined with Deferasirox.
Phenylephrine Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Siponimod.
Tipranavir Tipranavir The risk or severity of adverse effects can be increased when Tipranavir is combined with Siponimod.
Felbamate Felbamate The risk or severity of adverse effects can be increased when Felbamate is combined with Siponimod.
Ranolazine Ranolazine The metabolism of Siponimod can be decreased when combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Siponimod can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of hypertension can be increased when Rasagiline is combined with Siponimod.
Imatinib Imatinib The risk or severity of adverse effects can be increased when Imatinib is combined with Siponimod.
Bevacizumab Injection Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Siponimod.
Gefitinib Gefitinib The metabolism of Siponimod can be decreased when combined with Gefitinib.
Albuterol Albuterol The risk or severity of hypertension can be increased when Salbutamol is combined with Siponimod.
Paliperidone Paliperidone The risk or severity of hypertension can be increased when Paliperidone is combined with Siponimod.
Bortezomib Bortezomib The metabolism of Siponimod can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Siponimod.
Hepatitis B Vaccine Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Siponimod.
Influenza Vaccine, Inactivated or Recombinant Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Siponimod.
Influenza Vaccine, Live Intranasal Influenza Vaccine, Live Intranasal The therapeutic efficacy of Typhoid Vaccine Live can be decreased when used in combination with Siponimod.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The therapeutic efficacy of Varicella Zoster Vaccine (Live/attenuated) can be decreased when used in combination with Siponimod.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Siponimod.
Posaconazole Posaconazole The risk or severity of adverse effects can be increased when Posaconazole is combined with Siponimod.
Primaquine Primaquine The risk or severity of adverse effects can be increased when Primaquine is combined with Siponimod.
Rituximab Injection Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Siponimod.
Aliskiren Aliskiren Siponimod may decrease the antihypertensive activities of Aliskiren.
Darunavir Darunavir The risk or severity of adverse effects can be increased when Darunavir is combined with Siponimod.
Pemetrexed Injection Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Siponimod.
Lisdexamfetamine Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Siponimod.
Nabilone Nabilone The risk or severity of adverse effects can be increased when Nabilone is combined with Siponimod.
Vorinostat Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Siponimod.
Sorafenib Sorafenib The risk or severity of adverse effects can be increased when Sorafenib is combined with Siponimod.
Sunitinib Sunitinib The metabolism of Siponimod can be decreased when combined with Sunitinib.
Dronabinol Dronabinol The metabolism of Siponimod can be decreased when combined with Dronabinol.
Lapatinib Lapatinib The metabolism of Siponimod can be decreased when combined with Lapatinib.
Dasatinib Dasatinib The metabolism of Siponimod can be decreased when combined with Dasatinib.
Armodafinil Armodafinil The metabolism of Siponimod can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Siponimod.
Ivermectin Ivermectin The metabolism of Siponimod can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The risk or severity of adverse effects can be increased when Temsirolimus is combined with Siponimod.
Nelarabine Injection Nelarabine Injection The risk or severity of adverse effects can be increased when Nelarabine is combined with Siponimod.
Lenalidomide Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Siponimod.
Nilotinib Nilotinib The risk or severity of adverse effects can be increased when Nilotinib is combined with Siponimod.
Bexarotene Bexarotene The metabolism of Siponimod can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Siponimod can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Siponimod can be decreased when combined with Chloramphenicol.
Decitabine Injection Decitabine Injection The risk or severity of adverse effects can be increased when Decitabine is combined with Siponimod.
Desmopressin Desmopressin The risk or severity of hypertension can be increased when Desmopressin is combined with Siponimod.
Etravirine Etravirine The metabolism of Siponimod can be increased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Siponimod.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Siponimod can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Desvenlafaxine is combined with Siponimod.
Nebivolol Nebivolol Siponimod may decrease the antihypertensive activities of Nebivolol.
Tretinoin Tretinoin The metabolism of Siponimod can be decreased when combined with Tretinoin.
Bendamustine Injection Bendamustine Injection The risk or severity of adverse effects can be increased when Bendamustine is combined with Siponimod.
Pilocarpine Pilocarpine The metabolism of Siponimod can be decreased when combined with Pilocarpine.
Flecainide Flecainide The metabolism of Siponimod can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Siponimod can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The risk or severity of adverse effects can be increased when Ixabepilone is combined with Siponimod.
Irinotecan Injection Irinotecan Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Siponimod.
Estramustine Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Siponimod.
Mitotane Mitotane The therapeutic efficacy of Siponimod can be decreased when used in combination with Mitotane.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Siponimod.
Rufinamide Rufinamide The metabolism of Siponimod can be increased when combined with Rufinamide.
Midazolam Midazolam The metabolism of Siponimod can be decreased when combined with Midazolam.
Dexrazoxane Injection Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Siponimod.
Ibritumomab Injection Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Siponimod.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Milnacipran is combined with Siponimod.
Betaxolol Betaxolol Siponimod may decrease the antihypertensive activities of Betaxolol.
Iloperidone Iloperidone The risk or severity of hypertension can be increased when Iloperidone is combined with Siponimod.
Prasugrel Prasugrel The metabolism of Siponimod can be decreased when combined with Prasugrel.
Lacosamide Lacosamide The metabolism of Siponimod can be decreased when combined with Lacosamide.
Everolimus Everolimus The risk or severity of adverse effects can be increased when Everolimus is combined with Siponimod.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be decreased when combined with Siponimod.
Dronedarone Dronedarone The risk or severity of adverse effects can be increased when Dronedarone is combined with Siponimod.
Pralatrexate Injection Pralatrexate Injection The risk or severity of adverse effects can be increased when Pralatrexate is combined with Siponimod.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Siponimod.
Tapentadol Tapentadol The metabolism of Siponimod can be decreased when combined with Tapentadol.
Topotecan Topotecan The metabolism of Siponimod can be increased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Siponimod can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Siponimod can be decreased when combined with Pazopanib.
Asenapine Asenapine The risk or severity of hypertension can be increased when Asenapine is combined with Siponimod.
Pitavastatin Pitavastatin The metabolism of Siponimod can be decreased when combined with Pitavastatin.
Albendazole Albendazole The metabolism of Siponimod can be decreased when combined with Albendazole.
Denosumab Injection Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Siponimod.
Tocilizumab Injection Tocilizumab Injection The metabolism of Siponimod can be increased when combined with Tocilizumab.
Fingolimod Fingolimod Siponimod may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of adverse effects can be increased when Eribulin is combined with Siponimod.
Cabazitaxel Injection Cabazitaxel Injection The risk or severity of adverse effects can be increased when Cabazitaxel is combined with Siponimod.
Lurasidone Lurasidone The risk or severity of hypertension can be increased when Lurasidone is combined with Siponimod.
Acetaminophen Injection Acetaminophen Injection The metabolism of Siponimod can be increased when combined with Acetaminophen.
Vilazodone Vilazodone The risk or severity of hypertension can be increased when Vilazodone is combined with Siponimod.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Siponimod can be decreased when combined with Aldesleukin.
Sipuleucel-T Injection Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Siponimod.
Terbutaline Injection Terbutaline Injection The risk or severity of hypertension can be increased when Terbutaline is combined with Siponimod.
Belimumab Injection Belimumab Injection The risk or severity of adverse effects can be increased when Belimumab is combined with Siponimod.
Busulfan Injection Busulfan Injection The risk or severity of adverse effects can be increased when Busulfan is combined with Siponimod.
Roflumilast Roflumilast Roflumilast may increase the immunosuppressive activities of Siponimod.
Linagliptin Linagliptin The risk or severity of adverse effects can be increased when Linagliptin is combined with Siponimod.
Rilpivirine Rilpivirine The metabolism of Siponimod can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Siponimod can be decreased when combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Siponimod can be increased when combined with Cyclophosphamide.
Abiraterone Abiraterone The risk or severity of adverse effects can be increased when Abiraterone is combined with Siponimod.
Ticagrelor Ticagrelor The metabolism of Siponimod can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Siponimod can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The risk or severity of adverse effects can be increased when Ruxolitinib is combined with Siponimod.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Siponimod.
Clobazam Clobazam The metabolism of Siponimod can be increased when combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Siponimod can be increased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Siponimod can be decreased when combined with Vismodegib.
Belatacept Injection Belatacept Injection The risk or severity of adverse effects can be increased when Belatacept is combined with Siponimod.
Ivacaftor Ivacaftor The metabolism of Siponimod can be decreased when combined with Ivacaftor.
Basiliximab Injection Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Siponimod.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Siponimod.
Crizotinib Crizotinib The risk or severity of adverse effects can be increased when Crizotinib is combined with Siponimod.
Melphalan Injection Melphalan Injection The risk or severity of adverse effects can be increased when Melphalan is combined with Siponimod.
Cabergoline Cabergoline The metabolism of Siponimod can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The risk or severity of adverse effects can be increased when Naloxone is combined with Siponimod.
Ambrisentan Ambrisentan Siponimod may decrease the antihypertensive activities of Ambrisentan.
Eculizumab Injection Eculizumab Injection The risk or severity of adverse effects can be increased when Eculizumab is combined with Siponimod.
Carfilzomib Injection Carfilzomib Injection The risk or severity of adverse effects can be increased when Carfilzomib is combined with Siponimod.
Enzalutamide Enzalutamide The therapeutic efficacy of Siponimod can be decreased when used in combination with Enzalutamide.
Mirabegron Mirabegron The risk or severity of hypertension can be increased when Mirabegron is combined with Siponimod.
Regorafenib Regorafenib The metabolism of Siponimod can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Siponimod can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Siponimod can be increased when combined with Corticotropin.
Teriflunomide Teriflunomide The risk or severity of adverse effects can be increased when Teriflunomide is combined with Siponimod.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Siponimod can be decreased when combined with Cabozantinib.
Tofacitinib Tofacitinib Siponimod may increase the immunosuppressive activities of Tofacitinib.
Dimethyl Fumarate Dimethyl Fumarate The risk or severity of adverse effects can be increased when Dimethyl fumarate is combined with Siponimod.
Ponatinib Ponatinib The risk or severity of adverse effects can be increased when Ponatinib is combined with Siponimod.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Pomalidomide is combined with Siponimod.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Siponimod can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The metabolism of Siponimod can be decreased when combined with Apixaban.
Dabrafenib Dabrafenib The metabolism of Siponimod can be increased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Siponimod can be decreased when combined with Ospemifene.
Trametinib Trametinib The metabolism of Siponimod can be increased when combined with Trametinib.
Vortioxetine Vortioxetine The metabolism of Siponimod can be decreased when combined with Vortioxetine.
Perampanel Perampanel The metabolism of Siponimod can be increased when combined with Perampanel.
Ibrutinib Ibrutinib The risk or severity of adverse effects can be increased when Ibrutinib is combined with Siponimod.
Lomitapide Lomitapide The metabolism of Siponimod can be decreased when combined with Lomitapide.
Ketorolac Injection Ketorolac Injection The metabolism of Siponimod can be decreased when combined with Ketorolac.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of adverse effects can be increased when Obinutuzumab is combined with Siponimod.
Simeprevir Simeprevir The risk or severity of adverse effects can be increased when Simeprevir is combined with Siponimod.
Dapagliflozin Dapagliflozin The metabolism of Siponimod can be decreased when combined with Dapagliflozin.
Apremilast Apremilast The metabolism of Siponimod can be increased when combined with Apremilast.
Droxidopa Droxidopa The risk or severity of hypertension can be increased when Droxidopa is combined with Siponimod.
Ceritinib Ceritinib The metabolism of Siponimod can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Siponimod can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Siponimod can be increased when combined with Eslicarbazepine.
Vedolizumab Injection Vedolizumab Injection The risk or severity of adverse effects can be increased when Vedolizumab is combined with Siponimod.
Belinostat Injection Belinostat Injection The risk or severity of adverse effects can be increased when Belinostat is combined with Siponimod.
Idelalisib Idelalisib The risk or severity of adverse effects can be increased when Idelalisib is combined with Siponimod.
Testosterone Injection Testosterone Injection The metabolism of Siponimod can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Siponimod can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Siponimod can be decreased when combined with Vorapaxar.
Suvorexant Suvorexant The metabolism of Siponimod can be decreased when combined with Suvorexant.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Peginterferon beta-1a is combined with Siponimod.
Olaparib Olaparib The metabolism of Siponimod can be decreased when combined with Olaparib.
Blinatumomab Injection Blinatumomab Injection The risk or severity of adverse effects can be increased when Blinatumomab is combined with Siponimod.
Methamphetamine Methamphetamine The risk or severity of hypertension can be increased when Metamfetamine is combined with Siponimod.
Tasimelteon Tasimelteon The metabolism of Siponimod can be decreased when combined with Tasimelteon.
Riociguat Riociguat Siponimod may decrease the antihypertensive activities of Riociguat.
Lanreotide Injection Lanreotide Injection The metabolism of Siponimod can be decreased when combined with Lanreotide.
Pirfenidone Pirfenidone The risk or severity of adverse effects can be increased when Pirfenidone is combined with Siponimod.
Nintedanib Nintedanib The metabolism of Siponimod can be decreased when combined with Nintedanib.
Secukinumab Injection Secukinumab Injection The metabolism of Siponimod can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of hypertension can be increased when Risperidone is combined with Siponimod.
Palbociclib Palbociclib The metabolism of Siponimod can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Siponimod can be increased when combined with Lenvatinib.
Panobinostat Panobinostat The risk or severity of adverse effects can be increased when Panobinostat is combined with Siponimod.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Dinutuximab is combined with Siponimod.
Haloperidol Injection Haloperidol Injection The risk or severity of adverse effects can be increased when Haloperidol is combined with Siponimod.
Isavuconazonium Injection Isavuconazonium Injection The risk or severity of adverse effects can be increased when Isavuconazonium is combined with Siponimod.
Macitentan Macitentan Siponimod may decrease the antihypertensive activities of Macitentan.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Siponimod.
Flibanserin Flibanserin The risk or severity of hypertension can be increased when Flibanserin is combined with Siponimod.
Prednisolone Prednisolone The metabolism of Siponimod can be increased when combined with Prednisolone.
Brexpiprazole Brexpiprazole The risk or severity of hypertension can be increased when Brexpiprazole is combined with Siponimod.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Siponimod.
Cariprazine Cariprazine The risk or severity of hypertension can be increased when Cariprazine is combined with Siponimod.
Cobimetinib Cobimetinib The metabolism of Siponimod can be decreased when combined with Cobimetinib.
Mepolizumab Injection Mepolizumab Injection The risk or severity of adverse effects can be increased when Mepolizumab is combined with Siponimod.
Trabectedin Injection Trabectedin Injection The metabolism of Siponimod can be decreased when combined with Trabectedin.
Osimertinib Osimertinib The metabolism of Siponimod can be increased when combined with Osimertinib.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Siponimod.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Siponimod.
Rifapentine Rifapentine The metabolism of Siponimod can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Siponimod can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Siponimod can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The therapeutic efficacy of Siponimod can be decreased when used in combination with Dexamethasone.
Ixekizumab Injection Ixekizumab Injection The risk or severity of adverse effects can be increased when Ixekizumab is combined with Siponimod.
Brivaracetam Injection Brivaracetam Injection The metabolism of Siponimod can be decreased when combined with Brivaracetam.
Venetoclax Venetoclax The risk or severity of adverse effects can be increased when Venetoclax is combined with Siponimod.
Cobicistat Cobicistat The risk or severity of adverse effects can be increased when Cobicistat is combined with Siponimod.
Midodrine Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Siponimod.
Selexipag Selexipag Siponimod may decrease the antihypertensive activities of Selexipag.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Siponimod can be decreased when combined with Diphenhydramine.
Furosemide Injection Furosemide Injection Siponimod may decrease the antihypertensive activities of Furosemide.
Rucaparib Rucaparib The metabolism of Siponimod can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The risk or severity of adverse effects can be increased when Ribociclib is combined with Siponimod.
Brodalumab Injection Brodalumab Injection The risk or severity of adverse effects can be increased when Brodalumab is combined with Siponimod.
Brigatinib Brigatinib The metabolism of Siponimod can be increased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Siponimod can be decreased when combined with Doxepin.
Deflazacort Deflazacort The metabolism of Siponimod can be increased when combined with Deflazacort.
Safinamide Safinamide The metabolism of Siponimod can be decreased when combined with Safinamide.
Ocrelizumab Injection Ocrelizumab Injection The risk or severity of adverse effects can be increased when Ocrelizumab is combined with Siponimod.
Sarilumab Injection Sarilumab Injection The metabolism of Siponimod can be increased when combined with Sarilumab.
Midostaurin Midostaurin The therapeutic efficacy of Siponimod can be decreased when used in combination with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Siponimod.
Guselkumab Injection Guselkumab Injection The risk or severity of adverse effects can be increased when Guselkumab is combined with Siponimod.
Enasidenib Enasidenib The metabolism of Siponimod can be decreased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Siponimod can be increased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Siponimod.
Delafloxacin Delafloxacin The metabolism of Siponimod can be increased when combined with Delafloxacin.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Siponimod.
Acalabrutinib Acalabrutinib The metabolism of Siponimod can be decreased when combined with Acalabrutinib.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Siponimod.
Letermovir Letermovir The metabolism of Siponimod can be decreased when combined with Letermovir.
Buprenorphine Injection Buprenorphine Injection The metabolism of Siponimod can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The therapeutic efficacy of Siponimod can be decreased when used in combination with Apalutamide.
Penicillamine Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Siponimod.
Fostamatinib Fostamatinib The metabolism of Siponimod can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The metabolism of Siponimod can be increased when combined with Avatrombopag.
Baricitinib Baricitinib The risk or severity of adverse effects can be increased when Baricitinib is combined with Siponimod.
Lofexidine Lofexidine Siponimod may decrease the antihypertensive activities of Lofexidine.
Ivosidenib Ivosidenib The metabolism of Siponimod can be increased when combined with Ivosidenib.
Cannabidiol Cannabidiol The metabolism of Siponimod can be decreased when combined with Cannabidiol.
Dacomitinib Dacomitinib The metabolism of Siponimod can be decreased when combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Siponimod can be decreased when combined with Duvelisib.
Stiripentol Stiripentol The risk or severity of adverse effects can be increased when Stiripentol is combined with Siponimod.
Gilteritinib Gilteritinib The metabolism of Siponimod can be decreased when combined with Gilteritinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Siponimod can be increased when combined with Paclitaxel.
Rifamycin Rifamycin The therapeutic efficacy of Siponimod can be decreased when used in combination with Rifamycin.
Prucalopride Prucalopride The metabolism of Siponimod can be decreased when combined with Prucalopride.
Ravulizumab-cwvz Injection Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Ravulizumab is combined with Siponimod.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Siponimod can be increased when combined with Emapalumab.
Erdafitinib Erdafitinib The metabolism of Siponimod can be decreased when combined with Erdafitinib.
Risankizumab-rzaa Injection Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Siponimod is combined with Risankizumab.
Alpelisib Alpelisib The therapeutic efficacy of Siponimod can be decreased when used in combination with Alpelisib.
Cladribine Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Siponimod.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Siponimod.
Triclabendazole Triclabendazole The metabolism of Siponimod can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Siponimod.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Siponimod.
Istradefylline Istradefylline The metabolism of Siponimod can be decreased when combined with Istradefylline.
Pitolisant Pitolisant The serum concentration of Siponimod can be decreased when it is combined with Pitolisant.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Siponimod.
Phenytoin Injection Phenytoin Injection The therapeutic efficacy of Siponimod can be decreased when used in combination with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The therapeutic efficacy of Siponimod can be decreased when used in combination with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Siponimod.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Siponimod.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Siponimod.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Siponimod.
Cenobamate Cenobamate The serum concentration of Siponimod can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The risk or severity of adverse effects can be increased when Siponimod is combined with Ozanimod.
Selumetinib Selumetinib The metabolism of Siponimod can be decreased when combined with Selumetinib.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Siponimod.
Selpercatinib Selpercatinib The risk or severity of hypertension can be increased when Siponimod is combined with Selpercatinib.
Octreotide Octreotide The serum concentration of Siponimod can be increased when it is combined with Octreotide.
Pralsetinib Pralsetinib The metabolism of Siponimod can be increased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Siponimod can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Siponimod is combined with Naxitamab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Siponimod can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Siponimod can be increased when combined with Vitamin E.
Theophylline Theophylline The metabolism of Siponimod can be decreased when combined with Theophylline.
Fenoprofen Fenoprofen The risk or severity of hypertension can be increased when Fenoprofen is combined with Siponimod.
Indomethacin Indomethacin The metabolism of Siponimod can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The metabolism of Siponimod can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Siponimod can be decreased when combined with Naproxen.
Tolmetin Tolmetin The risk or severity of hypertension can be increased when Tolmetin is combined with Siponimod.
Sulindac Sulindac The risk or severity of hypertension can be increased when Sulindac is combined with Siponimod.
Trazodone Trazodone The risk or severity of hypertension can be increased when Trazodone is combined with Siponimod.
Hydroxyurea Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Siponimod.
Floxuridine Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Siponimod.
Phenobarbital Phenobarbital The therapeutic efficacy of Siponimod can be decreased when used in combination with Phenobarbital.
Methotrexate Injection Methotrexate Injection The risk or severity of adverse effects can be increased when Methotrexate is combined with Siponimod.
Primidone Primidone The therapeutic efficacy of Siponimod can be decreased when used in combination with Primidone.
Diethylpropion Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Siponimod.
Chlorpromazine Chlorpromazine The metabolism of Siponimod can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Siponimod can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Siponimod can be decreased when combined with Lorazepam.
Phenoxybenzamine Phenoxybenzamine Siponimod may decrease the antihypertensive activities of Phenoxybenzamine.
Carmustine Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Siponimod.
Bromocriptine Bromocriptine The metabolism of Siponimod can be decreased when combined with Bromocriptine.
Metaproterenol Metaproterenol The risk or severity of hypertension can be increased when Orciprenaline is combined with Siponimod.
Tranylcypromine Tranylcypromine The metabolism of Siponimod can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Siponimod can be decreased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Siponimod.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Siponimod.
Tetracycline Tetracycline The metabolism of Siponimod can be decreased when combined with Tetracycline.
Thioguanine Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Siponimod.
Prochlorperazine Prochlorperazine The metabolism of Siponimod can be decreased when combined with Prochlorperazine.
Thioridazine Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Siponimod.
Trifluoperazine Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Siponimod.
Bleomycin Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Siponimod.
Dapsone Dapsone The metabolism of Siponimod can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Siponimod can be decreased when combined with Sulfadiazine.
Methadone Methadone The metabolism of Siponimod can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Siponimod can be decreased when combined with Oxybutynin.
Ibuprofen Ibuprofen The metabolism of Siponimod can be decreased when combined with Ibuprofen.
Orphenadrine Orphenadrine The metabolism of Siponimod can be decreased when combined with Orphenadrine.
Azathioprine Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Siponimod.
Phentermine Phentermine The metabolism of Siponimod can be decreased when combined with Phentermine.
Methylphenidate Methylphenidate The risk or severity of hypertension can be increased when Methylphenidate is combined with Siponimod.
Amoxapine Amoxapine The risk or severity of hypertension can be increased when Amoxapine is combined with Siponimod.
Sulfasalazine Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Siponimod.
Hydrocortisone Hydrocortisone The metabolism of Siponimod can be increased when combined with Hydrocortisone.
Lomustine Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Siponimod.
Doxorubicin Doxorubicin The metabolism of Siponimod can be decreased when combined with Doxorubicin.
Cytarabine Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Siponimod.
Mechlorethamine Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Siponimod.
Dactinomycin Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Siponimod.
Carbamazepine Carbamazepine The therapeutic efficacy of Siponimod can be decreased when used in combination with Carbamazepine.
Methyldopa Methyldopa Siponimod may decrease the antihypertensive activities of Methyldopa.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Siponimod.
Prazosin Prazosin Siponimod may decrease the antihypertensive activities of Prazosin.
Hydralazine Hydralazine The metabolism of Hydralazine can be decreased when combined with Siponimod.
Cimetidine Cimetidine The metabolism of Siponimod can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Siponimod can be decreased when combined with Warfarin.
Loperamide Loperamide The risk or severity of adverse effects can be increased when Loperamide is combined with Siponimod.
Promethazine Promethazine The metabolism of Siponimod can be decreased when combined with Promethazine.
Meclofenamate Meclofenamate The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Siponimod.
Daunorubicin Daunorubicin The metabolism of Siponimod can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Siponimod can be increased when combined with Griseofulvin.
Quinine Quinine The metabolism of Siponimod can be increased when combined with Quinine.
Calcitriol Calcitriol The metabolism of Siponimod can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The risk or severity of adverse effects can be increased when Sulfinpyrazone is combined with Siponimod.
Chlorothiazide Chlorothiazide Siponimod may decrease the antihypertensive activities of Chlorothiazide.
Chlorthalidone Chlorthalidone Siponimod may decrease the antihypertensive activities of Chlorthalidone.
Metolazone Metolazone Siponimod may decrease the antihypertensive activities of Metolazone.
Secobarbital Secobarbital The metabolism of Siponimod can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Siponimod can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The metabolism of Siponimod can be decreased when combined with Amitriptyline.
Imipramine Imipramine The risk or severity of hypertension can be increased when Imipramine is combined with Siponimod.
Probenecid Probenecid The metabolism of Siponimod can be increased when combined with Probenecid.
Quinidine Quinidine The risk or severity of adverse effects can be increased when Quinidine is combined with Siponimod.
Isoniazid Isoniazid The risk or severity of adverse effects can be increased when Isoniazid is combined with Siponimod.
Rifampin Rifampin The therapeutic efficacy of Siponimod can be decreased when used in combination with Rifampicin.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Siponimod.
Tamoxifen Tamoxifen The metabolism of Siponimod can be decreased when combined with Tamoxifen.
Mitomycin Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Siponimod.
Methimazole Methimazole The risk or severity of adverse effects can be increased when Methimazole is combined with Siponimod.
Propylthiouracil Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Siponimod.
Chlorpropamide Chlorpropamide The metabolism of Siponimod can be decreased when combined with Chlorpropamide.
Tolbutamide Tolbutamide The metabolism of Siponimod can be decreased when combined with Tolbutamide.
Tolazamide Tolazamide The metabolism of Siponimod can be decreased when combined with Tolazamide.
Dextromethorphan Dextromethorphan The metabolism of Siponimod can be decreased when combined with Dextromethorphan.
Niacin Niacin The metabolism of Siponimod can be decreased when combined with Niacin.
Hydrochlorothiazide Hydrochlorothiazide Siponimod may decrease the antihypertensive activities of Hydrochlorothiazide.
Danazol Danazol The risk or severity of adverse effects can be increased when Danazol is combined with Siponimod.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Siponimod may decrease the antihypertensive activities of Propranolol.
Minoxidil Minoxidil Siponimod may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Siponimod.
Nortriptyline Nortriptyline The metabolism of Siponimod can be decreased when combined with Nortriptyline.
Amphotericin B Injection Amphotericin B Injection The metabolism of Siponimod can be decreased when combined with Amphotericin B.
Mercaptopurine Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Siponimod.
Nadolol Nadolol Siponimod may decrease the antihypertensive activities of Nadolol.
Fluorouracil Injection Fluorouracil Injection The metabolism of Siponimod can be decreased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Siponimod can be increased when combined with Colchicine.
Cephalexin Cephalexin The metabolism of Siponimod can be decreased when combined with Cephalexin.
Dacarbazine Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Siponimod.
Acetazolamide Acetazolamide The metabolism of Siponimod can be decreased when combined with Acetazolamide.
Bacillus Calmette-Guerin (BCG) Vaccine Bacillus Calmette-Guerin (BCG) Vaccine The therapeutic efficacy of Bacillus calmette-guerin substrain tice live antigen can be decreased when used in combination with Siponimod.
Ketoconazole Ketoconazole The risk or severity of adverse effects can be increased when Ketoconazole is combined with Siponimod.
Thiotepa Injection Thiotepa Injection The risk or severity of adverse effects can be increased when Thiotepa is combined with Siponimod.
Vincristine Injection Vincristine Injection The risk or severity of adverse effects can be increased when Vincristine is combined with Siponimod.
Captopril Captopril Siponimod may decrease the antihypertensive activities of Captopril.
Isoxsuprine Isoxsuprine The risk or severity of hypertension can be increased when Isoxsuprine is combined with Siponimod.
Vinblastine Vinblastine The metabolism of Siponimod can be increased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Siponimod can be decreased when combined with Metoprolol.
Aspirin Aspirin The metabolism of Siponimod can be decreased when combined with Acetylsalicylic acid.
Salsalate Salsalate The risk or severity of hypertension can be increased when Salsalate is combined with Siponimod.
Chlorambucil Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Siponimod.
Trimethoprim Trimethoprim The metabolism of Siponimod can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The risk or severity of adverse effects can be increased when Diltiazem is combined with Siponimod.
Nifedipine Nifedipine The metabolism of Siponimod can be increased when combined with Nifedipine.
Timolol Timolol Siponimod may decrease the antihypertensive activities of Timolol.
Verapamil Verapamil The risk or severity of adverse effects can be increased when Verapamil is combined with Siponimod.
Atenolol Atenolol Siponimod may decrease the antihypertensive activities of Atenolol.
Pindolol Pindolol Siponimod may decrease the antihypertensive activities of Pindolol.
Cisplatin Injection Cisplatin Injection The metabolism of Siponimod can be decreased when combined with Cisplatin.
Diflunisal Diflunisal The risk or severity of hypertension can be increased when Diflunisal is combined with Siponimod.
Piroxicam Piroxicam The metabolism of Siponimod can be decreased when combined with Piroxicam.
Streptozocin Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Siponimod.
Etoposide Etoposide The metabolism of Siponimod can be increased when combined with Etoposide.
Glyburide Glyburide The metabolism of Siponimod can be decreased when combined with Glyburide.
Glipizide Glipizide The metabolism of Siponimod can be decreased when combined with Glipizide.
Indapamide Indapamide Siponimod may decrease the antihypertensive activities of Indapamide.
Dicloxacillin Dicloxacillin The metabolism of Siponimod can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Siponimod can be increased when combined with Nafcillin.
Labetalol Labetalol Siponimod may decrease the antihypertensive activities of Labetalol.
Gemfibrozil Gemfibrozil The risk or severity of adverse effects can be increased when Gemfibrozil is combined with Siponimod.
Guanabenz Guanabenz Siponimod may decrease the antihypertensive activities of Guanabenz.
Ketoprofen Ketoprofen The risk or severity of hypertension can be increased when Ketoprofen is combined with Siponimod.
Pimozide Pimozide The metabolism of Siponimod can be decreased when combined with Pimozide.
Enalapril Enalapril Siponimod may decrease the antihypertensive activities of Enalapril.
Flurbiprofen Flurbiprofen The metabolism of Siponimod can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The risk or severity of adverse effects can be increased when Amiodarone is combined with Siponimod.
Buspirone Buspirone The risk or severity of hypertension can be increased when Buspirone is combined with Siponimod.
Lovastatin Lovastatin The risk or severity of adverse effects can be increased when Lovastatin is combined with Siponimod.
Ciprofloxacin Ciprofloxacin The risk or severity of adverse effects can be increased when Ciprofloxacin is combined with Siponimod.
Mesalamine Mesalamine The risk or severity of hypertension can be increased when Mesalazine is combined with Siponimod.
Diclofenac Diclofenac The metabolism of Siponimod can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The risk or severity of adverse effects can be increased when Fluoxetine is combined with Siponimod.
Nimodipine Nimodipine Siponimod may decrease the antihypertensive activities of Nimodipine.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Siponimod.
Clozapine Clozapine The risk or severity of adverse effects can be increased when Clozapine is combined with Siponimod.
Idarubicin Idarubicin The metabolism of Siponimod can be decreased when combined with Idarubicin.
Fludarabine Injection Fludarabine Injection The risk or severity of adverse effects can be increased when Fludarabine is combined with Siponimod.
Pentostatin Injection Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Siponimod.
Clarithromycin Clarithromycin The risk or severity of adverse effects can be increased when Clarithromycin is combined with Siponimod.
Benazepril Benazepril Siponimod may decrease the antihypertensive activities of Benazepril.
Etodolac Etodolac The metabolism of Siponimod can be decreased when combined with Etodolac.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Siponimod.
Fosinopril Fosinopril Siponimod may decrease the antihypertensive activities of Fosinopril.
Nabumetone Nabumetone The metabolism of Siponimod can be decreased when combined with Nabumetone.
Quinapril Quinapril Siponimod may decrease the antihypertensive activities of Quinapril.
Ramipril Ramipril Siponimod may decrease the antihypertensive activities of Ramipril.
Simvastatin Simvastatin The metabolism of Siponimod can be decreased when combined with Simvastatin.
Amlodipine Amlodipine Siponimod may decrease the antihypertensive activities of Amlodipine.
Teniposide Injection Teniposide Injection The metabolism of Siponimod can be decreased when combined with Teniposide.
Itraconazole Itraconazole The risk or severity of adverse effects can be increased when Itraconazole is combined with Siponimod.
Lisinopril Lisinopril Siponimod may decrease the antihypertensive activities of Lisinopril.
Oxaprozin Oxaprozin The risk or severity of hypertension can be increased when Oxaprozin is combined with Siponimod.
Atovaquone Atovaquone The metabolism of Siponimod can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Siponimod can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol Siponimod may decrease the antihypertensive activities of Bisoprolol.
Zolpidem Zolpidem The metabolism of Siponimod can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Siponimod.
Terazosin Terazosin Siponimod may decrease the antihypertensive activities of Terazosin.
Isradipine Isradipine The risk or severity of adverse effects can be increased when Isradipine is combined with Siponimod.
Omeprazole Omeprazole The metabolism of Siponimod can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Siponimod can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Siponimod can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The metabolism of Siponimod can be decreased when combined with Venlafaxine.
Famciclovir Famciclovir The metabolism of Siponimod can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The risk or severity of adverse effects can be increased when Fluvoxamine is combined with Siponimod.
Nefazodone Nefazodone The risk or severity of adverse effects can be increased when Nefazodone is combined with Siponimod.
Losartan Losartan The metabolism of Losartan can be decreased when combined with Siponimod.
Vinorelbine Injection Vinorelbine Injection The risk or severity of adverse effects can be increased when Vinorelbine is combined with Siponimod.
Carboplatin Injection Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Siponimod.
Moexipril Moexipril Siponimod may decrease the antihypertensive activities of Moexipril.
Lansoprazole Lansoprazole The metabolism of Siponimod can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Siponimod can be increased when combined with Ifosfamide.
Pegaspargase Injection Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Siponimod.
Nicardipine Nicardipine The risk or severity of adverse effects can be increased when Nicardipine is combined with Siponimod.
Bupropion Bupropion The metabolism of Siponimod can be decreased when combined with Bupropion.
Ticlopidine Ticlopidine The metabolism of Siponimod can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The risk or severity of adverse effects can be increased when Saquinavir is combined with Siponimod.
Nisoldipine Nisoldipine Siponimod may decrease the antihypertensive activities of Nisoldipine.
Glimepiride Glimepiride The metabolism of Siponimod can be decreased when combined with Glimepiride.
Gemcitabine Injection Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Siponimod.
Ritonavir Ritonavir The risk or severity of adverse effects can be increased when Ritonavir is combined with Siponimod.
Docetaxel Injection Docetaxel Injection The metabolism of Siponimod can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Siponimod can be decreased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Siponimod can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Siponimod can be decreased when combined with Mirtazapine.
Trandolapril Trandolapril Siponimod may decrease the antihypertensive activities of Trandolapril.
Topiramate Topiramate The metabolism of Siponimod can be increased when combined with Topiramate.
Zileuton Zileuton The metabolism of Siponimod can be decreased when combined with Zileuton.
Valsartan Valsartan The metabolism of Valsartan can be decreased when combined with Siponimod.
Donepezil Donepezil The metabolism of Siponimod can be decreased when combined with Donepezil.
Nelfinavir Nelfinavir The metabolism of Siponimod can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Siponimod can be decreased when combined with Azithromycin.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Siponimod.
Nilutamide Nilutamide The metabolism of Siponimod can be decreased when combined with Nilutamide.
Selegiline Selegiline The metabolism of Siponimod can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Siponimod can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Siponimod can be decreased when combined with Sertraline.
Propafenone Propafenone The risk or severity of hypertension can be increased when Propafenone is combined with Siponimod.
Raloxifene Raloxifene The metabolism of Siponimod can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Siponimod.
Finasteride Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Siponimod.
Quetiapine Quetiapine The risk or severity of hypertension can be increased when Quetiapine is combined with Siponimod.
Paroxetine Paroxetine The metabolism of Siponimod can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Siponimod can be decreased when combined with Tolcapone.
Citalopram Citalopram The metabolism of Siponimod can be decreased when combined with Citalopram.
Capecitabine Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Siponimod.
Efavirenz Efavirenz The risk or severity of adverse effects can be increased when Efavirenz is combined with Siponimod.
Sildenafil Sildenafil The metabolism of Siponimod can be decreased when combined with Sildenafil.
Trastuzumab Injection Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Siponimod.
Celecoxib Celecoxib The metabolism of Siponimod can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Siponimod can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The metabolism of Siponimod can be decreased when combined with Tolterodine.
Thalidomide Thalidomide The metabolism of Siponimod can be decreased when combined with Thalidomide.
Balsalazide Balsalazide The risk or severity of hypertension can be increased when Balsalazide is combined with Siponimod.
Nateglinide Nateglinide The metabolism of Siponimod can be decreased when combined with Nateglinide.
Rabeprazole Rabeprazole The metabolism of Siponimod can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Siponimod can be increased when combined with Terbinafine.

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