FDA-filed SPL labeling · retrieved through openFDA

Tocilizumab Injection

Tocilizumab injection is a prescription biologic that treats inflammatory conditions including rheumatoid arthritis, giant cell arteritis, juvenile idiopathic arthritis, systemic sclerosis-associated interstitial lung disease, cytokine release syndrome, and severe COVID-19.

Brand names ActemraTyenneTofidenceAvtozmaTocilizumab-anoh +1 more
Drug class Interleukin-6 Receptor Antagonist
Rx Form 1 Routes Intravenous · Subcutaneous
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 5 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveJan 23, 2026
Clinical labels in scope 5
AvailabilityRx
Earliest approval/marketing year 2010
FDA-listed product records 44
Boxed warningYes
How we combine label and product data →
No current FDA shortage listed · checked Sep 23, 2026
Tocilizumab Injection at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Tocilizumab injection is a powerful biologic that calms dangerous inflammation in conditions ranging from rheumatoid arthritis to severe COVID-19, but it meaningfully suppresses the immune system, making infection monitoring and regular blood tests essential. It is given by IV infusion or subcutaneous injection depending on your condition, and your healthcare team will guide the schedule. Take the infection warning seriously — early reporting of any fever or illness can be life-saving.
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert

Tocilizumab carries a serious FDA boxed warning about the risk of life-threatening infections. People taking tocilizumab are at increased risk for severe infections — including tuberculosis (TB), bacterial infections, invasive fungal infections, and viral infections — that can require hospitalization or cause death. This risk is greatest in people also taking other immune-suppressing drugs. If you develop a serious infection, treatment must be stopped until it is controlled. Before starting (except for COVID-19), you must be tested for latent (hidden) TB; if the test is positive, TB treatment should begin before tocilizumab. Even if your TB test is negative, watch for TB symptoms throughout treatment — persistent cough, night sweats, and unexplained weight loss. Report any signs of infection to your doctor right away.

Read the full warning on DailyMed →

📖 Tocilizumab Injection: Patient Information Guide

A plain-language walkthrough of Tocilizumab Injection — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for

Tocilizumab injection is a biologic medication approved for several inflammatory, autoimmune, and immune-related conditions across multiple products and routes.

  • Rheumatoid arthritis (RA): Actemra (IV or subcutaneous) treats moderate to severe RA in adults who haven't responded adequately to other disease-modifying drugs (DMARDs)
  • Giant cell arteritis (GCA): Actemra (IV or subcutaneous) treats this blood vessel inflammation in adults, often alongside a steroid taper
  • Systemic sclerosis-associated interstitial lung disease (SSc-ILD): Actemra subcutaneous injection slows the rate of lung function decline in adults — IV is not approved for this use
  • Polyarticular juvenile idiopathic arthritis (PJIA): Actemra (IV or subcutaneous) treats active PJIA in patients 2 years and older
  • Systemic juvenile idiopathic arthritis (SJIA): Actemra (IV or subcutaneous) treats active SJIA in patients 2 years and older
  • Cytokine release syndrome (CRS): Actemra intravenous infusion treats severe or life-threatening CRS caused by CAR T-cell therapy in adults and children 2 and older
  • COVID-19: Actemra intravenous infusion treats hospitalized adults and children 2 and older with COVID-19 who are on systemic corticosteroids and need supplemental oxygen, mechanical ventilation, or ECMO
⚙️How it works

Tocilizumab is an IL-6 receptor antagonist — it blocks a pro-inflammatory signaling protein called interleukin-6 (IL-6). IL-6 is released by immune cells and drives inflammation throughout the body, activating immune cells, triggering liver proteins that fuel inflammation, and causing joint damage in diseases like rheumatoid arthritis. Tocilizumab attaches to both the free and cell-surface forms of the IL-6 receptor, preventing IL-6 from delivering its inflammatory signal and helping bring the immune response back under control.

💊How it's taken

Tocilizumab injection is given either by slow intravenous (IV) infusion over one hour in a clinical setting, or as a subcutaneous (under-the-skin) injection at home — the route and frequency depend on your specific condition. IV infusions are typically scheduled every 2 to 4 weeks depending on the indication; subcutaneous injections are given weekly or every other week. There are no food-related restrictions.

  • Do not change your dose schedule based on a single body weight reading — weight can fluctuate
  • If a dose adjustment or interruption is needed (for example, due to lab changes), your prescriber will guide you — do not adjust on your own
  • Always follow the Instructions for Use included with your specific product and device
🤒Side effects — in detail

The most commonly reported side effects with tocilizumab injection include:

  • Upper respiratory tract infections and nasopharyngitis (cold-like symptoms)
  • Headache
  • High blood pressure (hypertension)
  • Elevated liver enzymes (ALT) on blood tests
  • Injection site reactions (redness, pain, or swelling at the injection site)
  • Low white blood cell counts (neutropenia) — detected on blood tests
  • Low platelet counts (thrombocytopenia) — detected on blood tests
  • Increased cholesterol and triglyceride levels

Serious reactions to act on immediately include signs of infection (fever, chills, cough), severe stomach pain that could indicate intestinal perforation, signs of liver injury (jaundice, dark urine, fatigue), and any severe allergic reaction such as trouble breathing or throat tightening.

⚠️Warnings & precautions
  • Serious infections: Tocilizumab suppresses the immune system and substantially raises the risk of dangerous infections — including tuberculosis, bacterial pneumonia, fungal infections, herpes zoster, and sepsis. Do not start treatment during any active infection. Get tested for latent TB before starting (except COVID-19 patients).
  • Liver injury (hepatotoxicity): Serious liver damage, including cases requiring liver transplant or death, has been reported. Liver enzyme levels must be checked before and regularly during treatment. Stop the medication and contact your doctor if you develop jaundice, fatigue, or right-sided abdominal pain.
  • Gastrointestinal perforation: Holes in the intestine (perforations) have occurred, particularly in people with a history of diverticulitis. Seek immediate care for sudden severe abdominal pain with fever.
  • Blood count and lipid changes: Tocilizumab can lower white blood cells and platelets and raise cholesterol — regular monitoring with blood tests is required.
  • Severe allergic reactions: Anaphylaxis and fatal hypersensitivity reactions have occurred; a serious skin reaction called DRESS has also been reported. Infusions must be given in a setting where these can be treated immediately.
  • Malignancy risk: The long-term effect on cancer risk is not fully known; malignancies have been observed in clinical studies.
  • Live vaccines: Must be avoided during treatment — they may cause serious infection in people on immunosuppressive therapy.
🔀What it interacts with

Tocilizumab can interact with several types of medications — tell your prescriber and pharmacist about everything you take:

  • Live vaccines: Must not be given during tocilizumab treatment — risk of serious infection
  • CYP450-metabolized drugs (warfarin, cyclosporine, theophylline, oral contraceptives, lovastatin, atorvastatin, omeprazole, simvastatin, and others): Tocilizumab changes how the liver processes these drugs, potentially lowering their levels in your blood — doses may need monitoring and adjustment; this effect can last for weeks after stopping tocilizumab
  • Other biologic DMARDs (TNF blockers, IL-1 blockers, anti-CD20 drugs, co-stimulation modulators): Combining these with tocilizumab is not recommended due to a greatly increased risk of serious infections and immune suppression
  • Methotrexate and corticosteroids: Commonly used with tocilizumab, but they can increase liver enzyme elevations and infection risk — monitoring is required

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it
  • Active infection: Tocilizumab must not be started if you have any active infection, including localized ones
  • Tuberculosis history or exposure: You must be screened for latent TB before starting (COVID-19 patients excluded); positive results require treatment before beginning tocilizumab
  • Chronic or recurrent infections: Discuss your full infection history with your doctor — the risks and benefits must be carefully weighed
  • Diverticulitis or bowel problems: Risk of intestinal perforation is higher; use with caution
  • Liver disease or elevated liver enzymes: Not recommended if liver enzymes are significantly elevated at baseline; regular monitoring required
  • Low blood counts: Not recommended if white blood cell or platelet counts are below defined thresholds at the start of treatment
  • Pregnancy: Animal studies suggest possible fetal harm; monoclonal antibodies cross the placenta in the third trimester and may affect the baby's immune system — discuss risks and benefits with your doctor before becoming pregnant
  • Breastfeeding: It is not known whether tocilizumab passes into breast milk; weigh the benefits of breastfeeding against the potential risk with your doctor
  • Children under 2: Safety and effectiveness have not been fully established for most uses in this age group
  • Older adults (65+): Higher rate of serious infections compared to younger patients — closer monitoring is warranted
  • Known allergy to tocilizumab products: Tocilizumab is contraindicated if you have had a serious allergic reaction to it before
🚑If you take too much

Limited information is available on tocilizumab overdose. In one reported case, a patient accidentally received a very high IV dose with no adverse effects observed; in a healthy volunteer study, the highest doses caused temporary low white blood cell counts (neutropenia). If you or someone else may have received too much, seek medical attention — the recommended approach is monitoring for signs and symptoms and treating any reactions that develop.

📡Pharmacodynamics — effects in the body

After dosing, tocilizumab produces measurable drops in markers of inflammation — including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor, and fibrinogen — within about 2 weeks of starting treatment. Hemoglobin levels tend to rise. White blood cell (neutrophil) counts typically fall to their lowest point within 3–5 days after a dose, then recover gradually. Cholesterol and triglyceride levels increase during treatment and require monitoring. These measurable changes reflect the drug's effect on the IL-6 pathway, though how closely they correlate with clinical benefit varies.

🔬Pharmacokinetics — how your body processes it

Tocilizumab is eliminated from the body through a combination of two processes — a steady linear pathway and a saturable pathway (Michaelis-Menten elimination) — meaning higher doses lead to disproportionately greater drug exposure. The drug's half-life (how long it takes for half to leave the body) varies depending on concentration but can be up to about 21.5 days at high levels. Body weight significantly affects how the drug behaves, particularly with IV dosing. The drug's effect on liver enzyme activity (CYP450) can persist for several weeks after the last dose, meaning interactions with other medications may continue even after stopping tocilizumab.

📦How to store it

refrigerated at 36°F to 46°F (2ºC to 8ºC). Do not freeze. in the original carton until time of use, and keep syringes and autoinjectors dry.

📄 Written from Tocilizumab Injection’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

89

Supplements & herbs that interact with Tocilizumab Injection

89 supplements and herbal products have documented interactions with Tocilizumab Injection in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 3
  • Moderate · 85
  • Minor · 1
Every supplement checked against Tocilizumab Injection — ranked by severity The full interaction hub: 3 major · 85 moderate · 1 minor · every one linked to its full report. Check Tocilizumab Injection against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Tocilizumab Injection — the kind of thing our pharmacy team would talk through with you at the counter.

What conditions is this medication used for?
Tocilizumab injection is used for several serious inflammatory conditions. These include moderate to severe rheumatoid arthritis, giant cell arteritis, a lung condition tied to systemic sclerosis (SSc-ILD), and two types of juvenile arthritis in children 2 and older. It's also used in hospital settings for severe cytokine release syndrome — a dangerous immune overreaction from certain cancer treatments — and for hospitalized COVID-19 patients who need oxygen or breathing support. Not every brand or route covers every condition, so your prescriber will match the right form to your specific situation.
Is it true this can make me more likely to get sick? What should I watch for?
Yes — that's the most important thing to know. Because tocilizumab dials down your immune system, you are at real risk for serious infections like pneumonia, urinary tract infections, herpes zoster (shingles), tuberculosis, and certain fungal infections. Call your doctor right away if you develop a fever, chills, a persistent cough, painful urination, or any unusual symptoms. Don't wait to see if it improves on its own — infections can worsen quickly on this medication.
Do I need blood tests while I'm on this? What are they checking for?
Yes, regular blood tests are required throughout your treatment. Your doctor will monitor your liver enzymes, white blood cell count (neutrophils), and platelet count, usually starting a few weeks after your first dose and then every few months. Cholesterol and triglyceride levels are also checked, as this medication can raise them. These tests help catch problems early before they become serious, so please don't skip your monitoring appointments.
Can I get vaccines while I'm on tocilizumab?
Live vaccines — like the live shingles vaccine, live flu nasal spray, or MMR — must be avoided while you're on tocilizumab. Receiving a live vaccine when your immune system is suppressed could cause a serious infection. Talk to your doctor before getting any vaccine. If you're planning to start tocilizumab, it may be a good idea to update your vaccinations beforehand.
I take other medications. Will this interfere with them?
Possibly, yes. Tocilizumab affects liver enzymes that break down many common medications — including blood thinners like warfarin, immune-suppressing drugs like cyclosporine, cholesterol medications, oral contraceptives, and others. When you start or stop tocilizumab, the levels of those other drugs in your blood can shift, sometimes significantly. Your prescriber may need to adjust those doses and monitor levels more closely. Always share a full list of everything you take — including over-the-counter drugs and supplements — with your care team.
Is it safe to take this if I'm pregnant or trying to become pregnant?
This is an important conversation to have with your doctor before getting pregnant. Animal studies showed possible harm to developing fetuses at doses similar to those used in people. The medication also crosses the placenta in the third trimester, which could affect the baby's immune system. There isn't enough human data yet to be fully certain of the risks. If you're pregnant, planning to be, or breastfeeding, your prescriber can help you weigh the risks against the risks of leaving your underlying condition untreated.
Is Tocilizumab Injection available over the counter?
Tocilizumab Injection is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Tocilizumab Injection first available?
Tocilizumab Injection has been available in the United States since at least 2010, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Tocilizumab Injection?
Tocilizumab Injection is supplied by 5 manufacturers listed in the FDA NDC Directory, including CELLTRION USA, Inc., Genentech, Inc., Chugai Pharmaceutical Co., Ltd..

💬 Answers drafted from Tocilizumab Injection’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

💊 How Tocilizumab Injection comes

Tocilizumab Injection is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Injection

By injection · Into a vein · Under the skin
Brands Actemra Actemra ACTPen Avtozma Tocilizumab-anoh Tofidence
How this form is used
What it may be used for
  • Actemra intravenous infusion is approved for rheumatoid arthritis, giant cell arteritis, polyarticular and systemic juvenile idiopathic arthritis (ages 2+), cytokine release syndrome (ages 2+), and hospitalized COVID-19 (ages 2+)
  • Actemra subcutaneous injection is approved for rheumatoid arthritis, giant cell arteritis, SSc-ILD (systemic sclerosis-associated interstitial lung disease), and polyarticular and systemic juvenile idiopathic arthritis (ages 2+)
  • Actemra intravenous use is not approved for SSc-ILD; intravenous administration is approved for CRS and COVID-19 but subcutaneous is not
  • Tocilizumab-anoh is approved for the same indications as Actemra; always follow the specific product labeling provided with your prescription
Important instructions
  • Actemra intravenous doses are given as a single slow drip infusion over 1 hour — never as a rapid push or bolus; it must be administered by a healthcare professional
  • Actemra subcutaneous doses are injected under the skin using a prefilled syringe or, where studied, the prefilled Actemra ACTPen autoinjector — follow the Instructions for Use provided with your device
  • Actemra subcutaneous administration with the prefilled ACTPen autoinjector has not been studied for SSc-ILD — the prefilled syringe should be used for that indication
  • When switching from Actemra intravenous to subcutaneous dosing, give the first subcutaneous dose in place of the next scheduled IV dose — do not double up
Available strengths 6 strengths
44 FDA-listed product records

📊 Tocilizumab Injection across the U.S. market

How Tocilizumab Injection appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

1
Dose forms
5
Manufacturers
5
Brand names
44
FDA-listed product records
2010
First marketed
CELLTRION USA, Inc.43%
Genentech, Inc.34%
Chugai Pharmaceutical Co., Ltd.9%
Biogen MA Inc7%
Organon LLC7%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Tocilizumab Injection is used

A general measure of how commonly Tocilizumab Injection is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Tocilizumab Injection is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

43,670
Medicaid prescriptions filled (Q1–Q4 2025)
$118.4M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Tocilizumab Injection prescribed? Of the 1,596 medications we measure, Tocilizumab Injection ranks #657 by Medicaid prescriptions — more than 59% of them.

Where Tocilizumab Injection ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5

Utilization by Tocilizumab Injection product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 0.9 mL / 180 mg/mL auto-injector is the most-dispensed Tocilizumab Injection product — about 37% of these Medicaid prescriptions.

0.9 ML tocilizumab 180 MG/ML Auto-Injector Most dispensed

16,056 Medicaid prescriptions (Q1–Q4 2025) 37% of Tocilizumab Injection prescriptions shown $58M gross reimbursement (before rebates) ≈ $3,610 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2106073

20 ML tocilizumab 20 MG/ML Injection

7,830 Medicaid prescriptions (Q1–Q4 2025) 18% of Tocilizumab Injection prescriptions shown $19.9M gross reimbursement (before rebates) ≈ $2,544 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1657981

4 ML tocilizumab 20 MG/ML Injection

7,506 Medicaid prescriptions (Q1–Q4 2025) 17% of Tocilizumab Injection prescriptions shown $9.8M gross reimbursement (before rebates) ≈ $1,307 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1657974

0.9 ML tocilizumab 180 MG/ML Prefilled Syringe

5,043 Medicaid prescriptions (Q1–Q4 2025) 12% of Tocilizumab Injection prescriptions shown $17.7M gross reimbursement (before rebates) ≈ $3,514 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1441527

10 ML tocilizumab 20 MG/ML Injection

4,028 Medicaid prescriptions (Q1–Q4 2025) 9% of Tocilizumab Injection prescriptions shown $6.1M gross reimbursement (before rebates) ≈ $1,520 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1657979

0.9 ML tocilizumab-aazg 180 MG/ML Auto-Injector

2,268 Medicaid prescriptions (Q1–Q4 2025) 5% of Tocilizumab Injection prescriptions shown $5.2M gross reimbursement (before rebates) ≈ $2,283 per prescription (gross)

Summed across the 2 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2686045

0.9 ML tocilizumab-aazg 180 MG/ML Prefilled Syringe

525 Medicaid prescriptions (Q1–Q4 2025) 1% of Tocilizumab Injection prescriptions shown $1.2M gross reimbursement (before rebates) ≈ $2,212 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2686053

4 ML tocilizumab-aazg 20 MG/ML Injection

157 Medicaid prescriptions (Q1–Q4 2025) <1% of Tocilizumab Injection prescriptions shown $124,589 gross reimbursement (before rebates) ≈ $794 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2679431

20 ML tocilizumab-aazg 20 MG/ML Injection

137 Medicaid prescriptions (Q1–Q4 2025) <1% of Tocilizumab Injection prescriptions shown $223,357 gross reimbursement (before rebates) ≈ $1,630 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2679442

10 ML tocilizumab-aazg 20 MG/ML Injection

70 Medicaid prescriptions (Q1–Q4 2025) <1% of Tocilizumab Injection prescriptions shown $59,364 gross reimbursement (before rebates) ≈ $848 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2679440

4 ML tocilizumab-bavi 20 MG/ML Injection

35 Medicaid prescriptions (Q2–Q4 2025) <1% of Tocilizumab Injection prescriptions shown $16,890 gross reimbursement (before rebates) ≈ $483 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2680298

20 ML tocilizumab-bavi 20 MG/ML Injection

15 Medicaid prescriptions (Q1–Q4 2025) <1% of Tocilizumab Injection prescriptions shown $43,179 gross reimbursement (before rebates) ≈ $2,879 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2680296

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Tocilizumab Injection, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 13 of 18 listed Tocilizumab Injection NDCs with Medicaid activity.

🔍 Compare Tocilizumab Injection products

A representative set of FDA-listed product records for Tocilizumab Injection — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 44 of 44 products — FDA National Drug Code Directory. See every product, package size and price: browse all 44 Tocilizumab Injection NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Tocilizumab Injection RxCUI 612865 3 dose forms · 18 strengths
  1. Dose form (SCDF) Injection RxCUI 1657973 In current FDA listings

Look up RxCUI 612865 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Actemra Tyenne Tofidence Avtozma Tocilizumab-anoh Actemra ACTPen

🏭 Manufacturers & labelers

CELLTRION USA, Inc. 19 Genentech, Inc. 15 Chugai Pharmaceutical Co., Ltd. 4 Biogen MA Inc 3 Organon LLC 3

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jan 23, 2026
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Tocilizumab Injection.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Tocilizumab Injection after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
5
NDC products indexed
44
Distinct labelers/manufacturers represented
5
Linked representative label
CELLTRION USA, Inc.
Linked label effective
Jan 23, 2026
Composite sections available
26
Linked SPL Set ID
60381a7e-d7ae-4384-925d-c19c418d1663
Linked SPL Document ID
bacf86b8-9d2f-45d2-9c35-4f619ea494aa
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 5 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. CELLTRION USA, Inc. is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.