Medication interaction hub

What Supplements Interact with Tocilizumab?

Tocilizumab brand name: Actemra. Every interaction below applies to the brands too.

89 Interactions 3 Major 85 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Tocilizumab? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Tocilizumab against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Tocilizumab (Actemra) calms an overactive immune system in conditions like rheumatoid arthritis, and it is also known to strain the liver, which is exactly where its supplement interactions concentrate. This page deserves genuine care. Of the 89 ingredients on file, 38 can stress the liver on their own, and all three rated major sit in that group: Siberian cocklebur, which has caused outright liver failure, plus beer and wine, since alcohol compounds the risk of liver damage.

The other large cluster works the opposite way. Fifty-three ingredients, many of them popular immune boosters, may rev up the very immune activity tocilizumab is prescribed to quiet, potentially blunting its benefit. Those all rate moderate, as does almost everything else here (85 moderate plus a single minor). Read the liver entries first, and count regular drinking as part of that picture.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 85 Minor 1 No known interaction 1,363

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Tocilizumab: Top Interactions at a Glance

The most significant Tocilizumab supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 89 interacting ingredients — plus 1,363 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Tocilizumab + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Tocilizumabi

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Beer + Tocilizumabi

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Wine + Tocilizumabi

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Tocilizumab

All 1,452 ingredients in our database, ranked by severity — 89 with a Tocilizumab interaction on file and 1,363 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Tocilizumab?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Greater Celandine with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that greater celandine can adversely affect the liver.

Full Greater Celandine + Tocilizumab answer

Can you take Mace with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that mace lignans can suppress immune function.

Full Mace + Tocilizumab answer

Can you take Active Hexose Correlated Compound (ahcc) with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking AHCC might decrease the effects of immunosuppressant drugs.

Full Active Hexose Correlated Compound (ahcc) + Tocilizumab answer

Can you take Boswellia Serrata with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.

Full Boswellia Serrata + Tocilizumab answer

Can you take Buchu with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Tocilizumab answer

Can you take Bupleurum with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bupleurum might decrease the effects of immunosuppressants.

Full Bupleurum + Tocilizumab answer

Can you take Camphor with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.

Full Camphor + Tocilizumab answer

Can you take Cassia Cinnamon with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Cassia Cinnamon + Tocilizumab answer

Can you take Cat's Claw with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might interfere with immunosuppressive therapy.

Full Cat's Claw + Tocilizumab answer

Can you take Catechu with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, catechu might interfere with immunosuppressant therapy.

Full Catechu + Tocilizumab answer

Can you take Ceylon Leadwort with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has demonstrated immunosuppressant activity in animal research.

Full Ceylon Leadwort + Tocilizumab answer

Can you take Chaga with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaga might interfere with immunosuppressive therapy.

Full Chaga + Tocilizumab answer

Can you take Chaparral with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Chaparral + Tocilizumab answer

Can you take Comfrey with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Comfrey + Tocilizumab answer

Can you take Cordyceps with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.

Full Cordyceps + Tocilizumab answer

Can you take Echinacea with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea has immunostimulant activity which may interfere with immunosuppressant therapy.

Full Echinacea + Tocilizumab answer

Can you take Elderberry with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.

Full Elderberry + Tocilizumab answer

Can you take Eleuthero with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.

Full Eleuthero + Tocilizumab answer

Can you take Ephedra with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Ephedra + Tocilizumab answer

Can you take Epistane with Tocilizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Epistane + Tocilizumab answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Tocilizumab is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Tocilizumab, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Tocilizumab sits in 2 interaction categories. Open any one to see what the group means:

Immunosuppressants 53 ingredients

Medications that damp down the immune system. Supplements that stimulate immunity can work against them.

53 of the supplement ingredients on this page reach Tocilizumab through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Tocilizumab through this category.

About Tocilizumab

Tocilizumab injection is a prescription biologic that treats inflammatory conditions including rheumatoid arthritis, giant cell arteritis, juvenile idiopathic arthritis, systemic sclerosis-associated interstitial lung disease, cytokine release syndrome, and severe COVID-19.

Generic name: Tocilizumab  ·  Brand name: Actemra.

See the full Tocilizumab Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Tocilizumab

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Tocilizumab.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Tocilizumab & Supplements: Common Questions

What supplements interact with Tocilizumab?
More than you might expect — 89 in total, though they are far from equal: 3 are rated major, 85 moderate, and 1 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Beer, Wine.
Which Tocilizumab supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Beer and Wine. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Tocilizumab?
Usually yes — most people on Tocilizumab can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Actemra have the same supplement interactions as Tocilizumab?
Yes — Actemra all contain Tocilizumab, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Tocilizumab and my other medications?
This page covers Tocilizumab against supplements and herbal ingredients. Checking Tocilizumab against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Tocilizumab Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.