Khella - Actemra (Tocilizumab) Interaction
Herbal: Khella
Also Known As: Ammi visnaga, Ammi daucoides, Daucus visnaga, Ammi, Ammi Visnage, Bischofskrautfruchte, Bishop's Weed, Biznaga, Khellin, Khelline, Noukha, Toothpick Ammi, Toothpick Plant, Visnaga, Visnaga Fruit, Visnagin
Drug: Tocilizumab
Brand names:
Actemra
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 22, 2025
Interaction Details
Tocilizumab is classified as belonging to the following category: Hepatotoxic Drugs
Theoretically, khella might have additive adverse effects on the liver when used with hepatotoxic drugs. Khella can increase liver transaminases. Some drugs that can adversely affect the liver include acetaminophen (Tylenol), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), and many others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Harvengt C, Desager JP. HDL-cholesterol increase in normolipaemic subjects on khellin: a pilot study. Int J Clin Pharmacol Res 1983;3:363-6.
Khella Overview
Khella (Ammi visnaga) is a plant native to the Meditearran region and has traditionally been used as an herbal supplement. Khella contains several constituents, including 'khellin', which is found in the seeds of the plant. Khellin dietary supplements have been used to treat a variety of ailments, particularly respiratory problems such as asthma and bronchitis, and cardiovascular issues such as angina pectoris. It is believed to work by relaxing the smooth muscles of the airways, making it easier to breathe. It also is thought to dilate the blood vessels, which can help to lower blood pressure and improve blood flow to the heart. Khella has also been used for dermatological conditions, such as psoriasis and vitiligo.
Tocilizumab Overview
-
Tocilizumab injection is used alone or in combination with other medications to relieve the symptoms of certain types of arthritis and other conditions including:
-
rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function) in adults who have not been helped by other disease-modifying antirheumatic drugs (DMARDs),
-
giant cell arteritis (a condition that causes swelling of blood vessels, especially in the scalp and head) in adults,
-
systemic sclerosis-associated interstitial lung disease (SSc-ILD; also known as scleroderma-associated ILD: a lung disease that involves scarring of the lungs) in adults,
-
polyarticular juvenile idiopathic arthritis (PJIA; a type of childhood arthritis that affects five or more joints during the first six months of the condition, causing pain, swelling, and loss of function) in children 2 years of age or older.
-
systemic juvenile idiopathic arthritis (SJIA; a condition in children that causes inflammation in different areas of the body, causing fever, joint pain and swelling, loss of function, and delays in growth and development) in children 2 years of age or older,
-
cytokine release syndrome (a severe and possibly life-threatening reaction) in adults and children 2 years of age or older after receiving certain immunotherapy infusions.
-
-
Tocilizumab injection is in a class of medications called interleukin-6 (IL-6) receptor inhibitors. It works by blocking the activity of interleukin-6, a substance in the body that causes inflammation.
Khella - More Interactions
Khella interacts with 592 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
Return to the main supplement interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
Ask A Pharmacist About Your Herbal Questions!
Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
Ask A Pharmacist