Medication interaction hub

What Supplements Interact with Azathioprine?

Azathioprine brand names: Imuran, Azamune. Every interaction below applies to the brands too.

106 Interactions 4 Major 92 Moderate 10 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Azathioprine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Azathioprine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Azathioprine (Imuran) quiets an overactive immune system, which is why people take it after a transplant or for autoimmune disease, and it is also why I read this interaction list with real caution. Fully half of the 106 supplements on file, 53 of them, appear because they stimulate immunity and could blunt the very effect you depend on. Another 38 add strain to the liver, an organ azathioprine can already stress, and that group includes the worst offenders: Siberian cocklebur, which has been linked to outright liver failure, plus alcohol from beer or wine.

Only four entries rate major, and those four deserve your focus before the rest, which split into 92 moderate and 10 minor. A final set of 17, activated charcoal among them, can soak up or slow an oral dose, so avoid taking them at the same time as your azathioprine and read their full entries below.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 92 Minor 10 No known interaction 1,346

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Azathioprine: Top Interactions at a Glance

The Azathioprine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 106 interacting ingredients — plus 1,346 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Azathioprine Combinations Today

The Azathioprine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Astragalus + Azathioprinei

Theoretically, astragalus might interfere with immunosuppressive therapy.

Read the full interaction Major Likelihood Probable Wine + Azathioprinei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Moderate Likelihood Possible Bee Venom + Azathioprinei

Bee venom might stimulate immune system activity.Theoretically, bee venom might interfere with immunosuppressant therapy.

Read the full interaction Moderate Likelihood Possible Red Yeast Rice + Azathioprinei

Theoretically, concomitant use might increase the risk of liver damage.

Read the full interaction Moderate Likelihood Possible Bupleurum + Azathioprinei

Theoretically, bupleurum might decrease the effects of immunosuppressants.

Read the full interaction Moderate Likelihood Possible Cordyceps + Azathioprinei

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.

Read the full interaction
The complete list

Every Supplement Checked Against Azathioprine

All 1,452 ingredients in our database, ranked by severity — 106 with a Azathioprine interaction on file and 1,346 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Azathioprine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Astragalus with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astragalus might interfere with immunosuppressive therapy.

Full Astragalus + Azathioprine answer

Can you take Wine with Azathioprine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Wine + Azathioprine answer

Can you take Bee Venom with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bee venom might stimulate immune system activity.Theoretically, bee venom might interfere with immunosuppressant therapy.

Full Bee Venom + Azathioprine answer

Can you take Red Yeast Rice with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.

Full Red Yeast Rice + Azathioprine answer

Can you take Bupleurum with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bupleurum might decrease the effects of immunosuppressants.

Full Bupleurum + Azathioprine answer

Can you take Khella with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, khella might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Khella + Azathioprine answer

Can you take Kudzu with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Kudzu + Azathioprine answer

Can you take Larch Arabinogalactan with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.

Full Larch Arabinogalactan + Azathioprine answer

Can you take Ligandrol with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Ligandrol + Azathioprine answer

Can you take Lion's Mane Mushroom with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.

Full Lion's Mane Mushroom + Azathioprine answer

Can you take Mace with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that mace lignans can suppress immune function.

Full Mace + Azathioprine answer

Can you take Manchurian Thorn with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that high doses of Manchurian thorn can induce liver damage.

Full Manchurian Thorn + Azathioprine answer

Can you take Maritime Pine with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.

Full Maritime Pine + Azathioprine answer

Can you take Melatonin with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin might interfere with immunosuppressive therapy.

Full Melatonin + Azathioprine answer

Can you take Neem with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem might decrease the effectiveness of immunosuppressants.

Full Neem + Azathioprine answer

Can you take Niacin with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Full Niacin + Azathioprine answer

Can you take Noni with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.

Full Noni + Azathioprine answer

Can you take Ostarine with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.

Full Ostarine + Azathioprine answer

Can you take Padang Cassia with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people.

Full Padang Cassia + Azathioprine answer

Can you take Panax Ginseng with Azathioprine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng use might interfere with immunosuppressive therapy.

Full Panax Ginseng + Azathioprine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Azathioprine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Azathioprine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Azathioprine sits in 3 interaction categories. Open any one to see what the group means:

Immunosuppressants 53 ingredients

Medications that damp down the immune system. Supplements that stimulate immunity can work against them.

53 of the supplement ingredients on this page reach Azathioprine through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Azathioprine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Azathioprine through this category.

About Azathioprine

Azathioprine is an immunosuppressant used to help prevent kidney transplant rejection and to treat active rheumatoid arthritis.

Generic name: Azathioprine  ·  Brand names: Imuran, Azamune.

See the full Azathioprine drug information

Related: does Azathioprine deplete any nutrients?

Azathioprine has 2 reported nutrient associations in the research literature — see the Azathioprine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Azathioprine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Azathioprine.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Products that contain Azathioprine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Azathioprine.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Azathioprine & Supplements: Common Questions

What supplements interact with Azathioprine?
In our interaction database, 106 supplement and herbal ingredients have an interaction with Azathioprine on file — 4 rated major, 92 moderate, and 10 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Azathioprine supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal, Beer and Wine. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Azathioprine?
That depends entirely on which supplement. The honest answer for Azathioprine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Imuran have the same supplement interactions as Azathioprine?
Yes — Imuran, Azamune all contain Azathioprine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Azathioprine deplete any vitamins or nutrients?
It might — Azathioprine has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Azathioprine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Azathioprine and my other medications?
This page covers Azathioprine against supplements and herbal ingredients. Checking Azathioprine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Azathioprine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.