Azathioprine

219 interactions 2 explained in plain English 370 cited references

Also sold as: Azasan Azasan® Imuran Imuran®

About Azathioprine

Azathioprine is used with other medications to prevent transplant rejection (attack of the transplanted organ by the immune system) in people who received kidney transplants. It is also used to treat severe rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of f… Read the full Azathioprine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Febuxostat Peginterferon Alfa-2A Injection Atovaquone Acarbose Adenovirus Vaccine Type 4, Live Adenovirus Vaccine Type 7, Live

1 Contraindicated 213 Major 5 Moderate

All (219) Contraindicated (1) Major (213) Moderate (5)

Contraindicated

Azathioprine Febuxostat Uloric Increased azaTHIOprine exposure and an increased risk of hepatotoxicity Details

Major

Azathioprine Abacavir Ziagen An increased risk of hepatotoxicity Details Azathioprine Lisinopril Prinivil Explained Myelosuppression Details Azathioprine Acarbose Prandase® Explained An increased risk of hepatotoxicity Details Azathioprine Acetazolamide Diamox® Sequels® An increased risk of hepatotoxicity Details Azathioprine Adalimumab Injection Abrilada An increased risk of hepatotoxicity Details Azathioprine Albendazole Albendamax An increased risk of hepatotoxicity Details Azathioprine Allopurinol Aloprim An increased risk of myelosuppression, an increased risk of hepatotoxicity and an azaTHIOprine toxicity (nausea, vomiting, leukope... Details Azathioprine Allopurinol Injection Aloprim An increased risk of myelosuppression, an increased risk of hepatotoxicity and an azaTHIOprine toxicity (nausea, vomiting, leukope... Details Azathioprine Ambrisentan Letairis An increased risk of hepatotoxicity Details Azathioprine Atovaquone Mepron An increased risk of hepatotoxicity Details Azathioprine Azacitidine Onureg An increased risk of hepatotoxicity Details Azathioprine Adalimumab An increased risk of hepatotoxicity Details Azathioprine Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Azathioprine Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Azathioprine Alacepril Myelosuppression Details Azathioprine Alfalfa Reduced immunosuppressive drug effectiveness and acute transplant rejection Details Azathioprine Alprazolam Xanax An increased risk of hepatotoxicity Details Azathioprine Amiodarone Nexterone An increased risk of hepatotoxicity Details Azathioprine Anidulafungin An increased risk of hepatotoxicity Details Azathioprine Atomoxetine Atoncy An increased risk of hepatotoxicity Details Azathioprine Azithromycin AzaSite An increased risk of hepatotoxicity Details Azathioprine Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Azathioprine Balsalazide Colazal An increased risk of myelosuppression and an increased risk of hepatotoxicity Details Azathioprine Benazepril Lotensin Myelosuppression Details Azathioprine Bexarotene Targretin An increased risk of hepatotoxicity Details Azathioprine Bicalutamide Casodex An increased risk of hepatotoxicity Details Azathioprine Black Cohosh Reduced immunosuppressive drug effectiveness and acute transplant rejection Details Azathioprine Bortezomib Boruzu An increased risk of hepatotoxicity Details Azathioprine Bosentan An increased risk of hepatotoxicity Details Azathioprine Busulfan Busulfex An increased risk of hepatotoxicity Details Azathioprine Captopril Capoten® An increased risk of myelosuppression and an increased risk of hepatotoxicity Details Azathioprine Carbamazepine Carbatrol An increased risk of hepatotoxicity Details Azathioprine Caspofungin An increased risk of hepatotoxicity Details Azathioprine Cefadroxil Duricef® An increased risk of hepatotoxicity Details Azathioprine Cefdinir Omnicef® An increased risk of hepatotoxicity Details Azathioprine Chenodiol An increased risk of hepatotoxicity Details Azathioprine Chlorzoxazone Lorzone An increased risk of hepatotoxicity Details Azathioprine Cilazapril Myelosuppression Details Azathioprine Ciprofloxacin An increased risk of hepatotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.