Herb & supplement monograph

Ceylon Leadwort Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated June 2026

What is this page for?

First and foremost: how Ceylon Leadwort interacts with medications. The heart of this page is the interaction list — every drug Ceylon Leadwort is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Ceylon Leadwort is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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On this page

Ceylon Leadwort Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Ceylon Leadwort drug interaction appears low for most people, since none of its reported interactions have been confirmed in humans. Every listed interaction is rated moderate rather than major, and all rest on animal or lab research rather than human studies.

Interactions deserving the most attention

The combinations worth the most care involve medicines where small changes matter. Animal studies suggest Ceylon Leadwort may reduce platelet function, so people on anticoagulant or antiplatelet drugs should watch for unusual bleeding or bruising. It has both raised and lowered blood sugar in animals, which could affect how well diabetes medications work. It has also shown immune-dampening activity that could theoretically interfere with immunosuppressants, including closely monitored transplant medicines.

What the rest of the list means

Most of the long list comes from lab findings that a compound in Ceylon Leadwort may block several enzymes the body uses to clear medications. If that happened in people, many drug levels could rise, but so far it has not been shown to, so most of these interactions remain theoretical rather than proven problems.

Check your medications against Ceylon Leadwort

Based on HelloPharmacist’s Ceylon Leadwort interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Ceylon Leadwort

1099 medications have a known interaction with Ceylon Leadwort, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Ceylon Leadwort using our pharmacist-reviewed interaction data.

AI summaries are generated from our Ceylon Leadwort interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Ceylon Leadwort combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Ceylon Leadwort affects

Every type of medication (drug category) Ceylon Leadwort is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 10 drug categories Ceylon Leadwort interacts with

Anticoagulant/antiplatelet DrugsAntidiabetes DrugsCytochrome P450 1a2 (cyp1a2) SubstratesCytochrome P450 2b6 (cyp2b6) SubstratesCytochrome P450 2c9 (cyp2c9) SubstratesCytochrome P450 2d6 (cyp2d6) SubstratesCytochrome P450 2e1 (cyp2e1) SubstratesCytochrome P450 3a4 (cyp3a4) SubstratesEstrogensImmunosuppressants

Anticoagulant/Antiplatelet Drugs

There is some concern that Ceylon leadwort might potentiate the effects of anticoagulant and antiplatelet drugs and possibly increase the risk of bleeding. Ceylon leadwort root extract has been shown to decrease platelet adhesion and prolong bleeding in animals. However, this effect has not yet been demonstrated in humans. Until more is known, use cautiously in patients taking anticoagulant or antiplatelet drugs. Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.