Ceylon Leadwort + Relugolix, Estradiol, Norethindrone Acetate
Relugolix, Estradiol, Norethindrone Acetate brand name: Myfembree.
Relugolix, Estradiol, Norethindrone Acetate falls into 3 drug categories that Ceylon Leadwort can interact with; the most serious is rated moderate. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.
Read the full interaction reportCeylon Leadwort and Relugolix, Estradiol, Norethindrone Acetate
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Ceylon Leadwort interacts with whole categories of medication. Relugolix, Estradiol, Norethindrone Acetate falls into 3 of those categories, so it can interact with Ceylon Leadwort in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
1 of 3Why this applies to Relugolix, Estradiol, Norethindrone Acetate
Relugolix, Estradiol, Norethindrone Acetate falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Ceylon Leadwort interacts with.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the honest picture with Myfembree (relugolix, estradiol, and norethindrone). The concern is that plumbagin, a compound in Ceylon Leadwort, slowed down a liver enzyme called CYP1A2 in lab dishes. The estrogen part (estradiol) is partly handled by that enzyme, so in theory blocking it could let estrogen levels drift up a bit. That might mean more estrogen-type side effects like breast tenderness, nausea, headaches, bloating, or mood changes.
But I want to be clear: this is only test-tube evidence, not something seen in real patients, so I wouldn't lose sleep over it. Still, because Myfembree carries blood clot warnings, it's worth a quick chat with your pharmacist or doctor before adding this supplement.
- Chen A, Zhou X, Tang S, Liu M, Wang X. Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach. Sci Rep. 2016 Jun 22;6:28482. PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
2 of 3Relugolix, Estradiol, Norethindrone Acetate also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Myfembree combines three active medicines, and your body relies on a liver enzyme called CYP3A4 to help process them. Ceylon Leadwort contains a compound called plumbagin that, in lab studies, slowed down that same enzyme. If that effect carried over into people, the components of Myfembree could clear more slowly and build up a bit, which might mean more of the usual side effects like nausea, headache, hot flashes, breast tenderness, mood changes, or, with the estrogen and progestin parts, a theoretically higher risk of blood clots.
Here's the honest part: this is based only on test-tube research, not on real people, so we don't know if it actually happens. Still, since Myfembree already carries clotting warnings, I'd play it safe and check with your pharmacist or doctor before combining them.
- Chen A, Zhou X, Tang S, Liu M, Wang X. Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach. Sci Rep. 2016 Jun 22;6:28482. PubMed
ESTROGENS
3 of 3Relugolix, Estradiol, Norethindrone Acetate also falls under ESTROGENS.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to know with Myfembree (relugolix, estradiol, and norethindrone): one of its jobs is to deliver a steady, low dose of estrogen (estradiol) to keep your hormone levels balanced while treating fibroid or endometriosis symptoms. In lab studies only, Ceylon Leadwort root has shown anti-estrogenic activity, meaning it may push against estrogen's effects.
So in theory, taking it could blunt the estrogen part of your therapy. That might mean more hot flashes, night sweats, mood changes, or breakthrough bleeding. I'll be honest though, this is only test-tube evidence, not human studies, so we really don't know if it matters in real life. Since these hormones are carefully dosed, it's worth running it past your pharmacist or doctor before adding the supplement.
- Sandeep G, Dheeraj A, Sharma NK, Jhade D, Bharti A. Effect of plumbagin free alcohol extract of Plumbago zeylanica Linn. root on reproductive system of female Wistar rats. Asian Pac J Trop Med. 2011 Dec;4(12):978-84. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Ceylon Leadwort Also Interacts With Other Medications
Ceylon Leadwort has 1,098 moderate known drug interactions in our database — the Relugolix, Estradiol, Norethindrone Acetate one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Ceylon Leadwort
We haven’t checked that one against Ceylon Leadwort yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Ceylon Leadwort. Pick one to open its full report.
See Every Supplement That Interacts With Relugolix, Estradiol, Norethindrone Acetate
This page covers Ceylon Leadwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Relugolix, Estradiol, Norethindrone Acetate page lists 219 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).
By severity: 8 major · 174 moderate · 37 minor.
From our pharmacist’s overview on the Relugolix, Estradiol, Norethindrone Acetate page
“Grapefruit is where I would start on this page. Myfembree (relugolix, estradiol, and norethindrone acetate) depends on the CYP3A4 enzyme to be cleared, and grapefruit juice blocks that enzyme, raising drug levels and side effect risk.”
Reviewed by 2 · Jul 18, 2026
Open the Relugolix, Estradiol, Norethindrone Acetate interaction page
Taking Ceylon Leadwort as Part of a Dietary Supplement Product? Check It for Interactions
We hold 96 real supplement products containing Ceylon Leadwort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ceylon Leadwort. Your product may carry other ingredients that interact with Relugolix, Estradiol, Norethindrone Acetate too, on top of Ceylon Leadwort — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Ceylon Leadwort and Relugolix, Estradiol, Norethindrone Acetate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#576 of 1,452 supplements looked up here in the last 7 days
#316 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Ceylon Leadwort
What is Ceylon Leadwort?
- Digestive complaints and poor appetite
- Skin conditions and wounds (applied to the skin)
- Joint pain and swelling
- Traditional 'metabolism-boosting' tonics
- Antimicrobial folk remedy
Ceylon Leadwort (Plumbago zeylanica) is a plant long used in Ayurvedic and other traditional medicine systems, mainly for digestion, skin problems, and pain. Solid human studies are lacking, and the plant contains plumbagin, a compound that can irritate skin and tissues and may be unsafe in larger amounts. Talk to a pharmacist or doctor before using it, and avoid it in pregnancy.
About Relugolix, Estradiol, and Norethindrone
What Is Relugolix, Estradiol, and Norethindrone Used For?
Brand name: Myfembree
This combination is used in premenopausal women. Myfembree is approved for two conditions.
It treats heavy menstrual bleeding linked to uterine fibroids (also called leiomyomas). It also treats moderate to severe pain linked to endometriosis. Use is limited to 24 months because of the risk of bone loss that may not be reversible.
Other Drugs & Ceylon Leadwort
Browse every other medication we’ve checked against Ceylon Leadwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,098 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Bupropion ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Orphenadrine ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Indomethacin ›
- Insulin (human) ›
- Miconazole ›
- Morphine Sulfate ›
- Trimipramine ›
- Acetaminophen ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Ketoprofen ›
Showing 60 of 1,098 moderate interactions — see all 1,098 on the Ceylon Leadwort page.
No interaction 1,731 drugs checked — show the list
We also checked Ceylon Leadwort against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Rosuvastatin ›
- Isotretinoin ›
- Levothyroxine, Liothyronine ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Methotrexate ›
- Lisinopril ›
- Amoxicillin ›
- Azithromycin ›
- Pregabalin ›
- Doxycycline ›
- Gabapentin ›
- Lamotrigine ›
- Acyclovir ›
- Methylene Blue ›
- Ciprofloxacin ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Atenolol, Chlorthalidone ›
- Aminophylline, Amobarbital, Ephedrine ›
- Enalapril Maleate ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Ezetimibe ›
- Cephalexin ›
- Ephedrine, Phenobarbital, Theophylline ›
- Cyclopentolate ›
- Levetiracetam ›
- Levodopa ›
- Isoniazid, Pyrazinamide, Rifampin ›
- Daunorubicin, Cytarabine ›
- Bismuth Subcarbonate, Calcium Carbonate, Opium ›
- Carbidopa, Levodopa ›
- Thyroid Hormone ›
- Ceftolozane Sulfate, Tazobactam Sodium ›
- Hydrocortisone, Clioquinol, Pramoxine ›
- Amobarbital, Ephedrine Sulfate ›
- Alginic Acid, Aluminum Hydroxide ›
- Mannitol ›
- Sodium Bicarbonate (otc Drug) ›
- Measles, Mumps, Rubella Virus Live ›
- Peginterferon Alfa-2a, Ribavirin ›
- Spironolactone ›
- Aminolevulinic Acid Hydrochloride ›
- Atropine Methyl Nitrate, Digestive Enzymes ›
- Cytomegalovirus Immune Globulin ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Tubocurarine ›
- Candesartan Cilexetil, Hydrochlorothiazide ›
- Alpha-1 Proteinase Inhibitor ›
- Atenolol ›
- Roxithromycin ›
- Glycerol Phenylbutyrate ›
- Sulfadiazine, Trimethoprim ›
- Fosinopril, Hydrochlorothiazide ›
Showing the 60 most looked-up of 1,731 medications checked with no known interaction — see the full Ceylon Leadwort list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Relugolix, Estradiol, Norethindrone Acetate Is Linked to Lower Levels of 5 Nutrients
Natural Medicines records Relugolix, Estradiol, Norethindrone Acetate as a medicine that can lower these. This is not an interaction with Ceylon Leadwort — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Relugolix, Estradiol, Norethindrone Acetate nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Ceylon Leadwort and Relugolix, Estradiol, Norethindrone Acetate Together: Common Questions
Can you take Ceylon Leadwort with Relugolix, Estradiol, Norethindrone Acetate?
Why are there 3 interactions listed for Ceylon Leadwort and Relugolix, Estradiol, Norethindrone Acetate?
How serious is the Ceylon Leadwort and Relugolix, Estradiol, Norethindrone Acetate interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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