Ceylon Leadwort + Aspirin, Caffeine, Hydrocodone
Aspirin, Caffeine, Hydrocodone brand name: Damason-P.
Aspirin, Caffeine, Hydrocodone falls into 4 drug categories that Ceylon Leadwort can interact with; the most serious is rated moderate. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro.
Read the full interaction reportCeylon Leadwort and Aspirin, Caffeine, Hydrocodone
These two interact in 4 distinct ways. Each one is explained separately below.
Why Are There 4 Interactions?
Ceylon Leadwort interacts with whole categories of medication. Aspirin, Caffeine, Hydrocodone falls into 4 of those categories, so it can interact with Ceylon Leadwort in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
1 of 4Why this applies to Aspirin, Caffeine, Hydrocodone
Aspirin, Caffeine, Hydrocodone falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group Ceylon Leadwort interacts with.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the wrinkle with this combo: the hydrocodone in Damason-P leans on a liver enzyme called CYP2D6 to turn into its more active pain-relieving form. Ceylon Leadwort contains plumbagin, which slowed down that same enzyme in lab tests. If that happened in your body, you might get less pain relief from the hydrocodone, since it wouldn't be activated as well. The aspirin and caffeine parts aren't really affected here.
I'll be honest, this is only a test-tube finding, never confirmed in real people, so I wouldn't lose sleep over it. Still, if your pain pills suddenly seem weaker, that's worth mentioning. Before adding this supplement, please run it by your pharmacist or doctor first.
- Chen A, Zhou X, Tang S, Liu M, Wang X. Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach. Sci Rep. 2016 Jun 22;6:28482. PubMed
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
2 of 4Aspirin, Caffeine, Hydrocodone also falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
In this combo product (Damason-P), the piece that matters most here is the caffeine. Your body relies on an enzyme called CYP1A2 to clear caffeine out. Lab studies suggest plumbagin, a compound in Ceylon Leadwort, can slow that enzyme down. In theory, that could let caffeine build up a bit, leaving you feeling jittery, anxious, or with a racing heart and trouble sleeping.
I want to be honest about the evidence: this has only been seen in test tubes and animals, never reported in real people, so it's more of a maybe than a sure thing. The hydrocodone and aspirin parts aren't really affected by CYP1A2. Still, before pairing this supplement with your medication, run it by your pharmacist or doctor first.
- Chen A, Zhou X, Tang S, Liu M, Wang X. Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach. Sci Rep. 2016 Jun 22;6:28482. PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
3 of 4Aspirin, Caffeine, Hydrocodone also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combo pill (Damason-P) pairs aspirin, caffeine, and the opioid hydrocodone. The piece that matters here is hydrocodone, which your liver partly processes through the CYP3A4 enzyme. A compound in Ceylon Leadwort called plumbagin has been shown to slow that same enzyme, but only in lab dish testing so far, not in real people.
If that slowdown did happen in your body, hydrocodone could build up a bit, meaning more drowsiness, dizziness, constipation, or slowed breathing. Since this is only theoretical lab data, I wouldn't lose sleep over it, but I also wouldn't pair them casually. Please check with your pharmacist or doctor before taking the two together, especially since this product already contains a strong opioid.
- Chen A, Zhou X, Tang S, Liu M, Wang X. Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach. Sci Rep. 2016 Jun 22;6:28482. PubMed
ANTICOAGULANT/ANTIPLATELET DRUGS
4 of 4Aspirin, Caffeine, Hydrocodone also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Your Damason-P combo contains aspirin, which already thins the blood a bit by keeping platelets from clumping together. Here's the wrinkle: in animal studies, Ceylon Leadwort root also slowed platelet stickiness and made bleeding last longer. Stack the two and you could, in theory, see easier bruising, nosebleeds, bleeding gums, or stomach upset that's slower to stop.
I want to be straight with you though, this concern comes only from lab and animal research, not from people. So it's a reasonable caution rather than a proven problem. The caffeine and hydrocodone parts aren't the issue here. If you take this medication daily, just run the supplement by your pharmacist or doctor first before adding it.
- Vijayakumar R, Senthilvelan M, Ravindran R, Devi RS. Plumbago zeylanica action on blood coagulation profile with and without blood volume reduction. Vascul Pharmacol. 2006 Aug;45(2):86-90. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Ceylon Leadwort Also Interacts With Other Medications
Ceylon Leadwort has 1,096 moderate known drug interactions in our database — the Aspirin, Caffeine, Hydrocodone one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Ceylon Leadwort
We haven’t checked that one against Ceylon Leadwort yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Ceylon Leadwort. Pick one to open its full report.
See Every Supplement That Interacts With Aspirin, Caffeine, Hydrocodone
This page covers Ceylon Leadwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Caffeine, Hydrocodone page lists 398 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).
By severity: 17 major · 334 moderate · 47 minor.
From our pharmacist’s overview on the Aspirin, Caffeine, Hydrocodone page
“Damason-P packs three drugs into one tablet, the opioid hydrocodone, aspirin, and caffeine, so a supplement can collide with any one of them, and its list of 398 interacting ingredients earns real respect. More than 200 of those can add to aspirin's bleeding risk, while 78 can deepen the opioid's sedation.”
Reviewed by 2 · Jul 18, 2026
Taking Ceylon Leadwort as Part of a Dietary Supplement Product? Check It for Interactions
We hold 96 real supplement products containing Ceylon Leadwort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ceylon Leadwort. Your product may carry other ingredients that interact with Aspirin, Caffeine, Hydrocodone too, on top of Ceylon Leadwort — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Ceylon Leadwort and Aspirin, Caffeine, Hydrocodone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#507 of 1,452 supplements looked up here in the last 7 days
#427 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Ceylon Leadwort
What is Ceylon Leadwort?
- Digestive complaints and poor appetite
- Skin conditions and wounds (applied to the skin)
- Joint pain and swelling
- Traditional 'metabolism-boosting' tonics
- Antimicrobial folk remedy
Ceylon Leadwort (Plumbago zeylanica) is a plant long used in Ayurvedic and other traditional medicine systems, mainly for digestion, skin problems, and pain. Solid human studies are lacking, and the plant contains plumbagin, a compound that can irritate skin and tissues and may be unsafe in larger amounts. Talk to a pharmacist or doctor before using it, and avoid it in pregnancy.
Other Drugs & Ceylon Leadwort
Browse every other medication we’ve checked against Ceylon Leadwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,096 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Bupropion ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Orphenadrine ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Indomethacin ›
- Insulin (human) ›
- Miconazole ›
- Morphine Sulfate ›
- Trimipramine ›
- Acetaminophen ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Ketoprofen ›
Showing 60 of 1,096 moderate interactions — see all 1,096 on the Ceylon Leadwort page.
No interaction 1,733 drugs checked — show the list
We also checked Ceylon Leadwort against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Rosuvastatin ›
- Escitalopram ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Lisinopril ›
- Amoxicillin ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Gabapentin ›
- Isotretinoin ›
- Methylene Blue ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Candesartan Cilexetil ›
- Cephalexin ›
- Cyclopentolate ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Roxithromycin ›
- Mannitol ›
- Pegunigalsidase Alfa-iwxj ›
- Levetiracetam ›
- Daptomycin ›
- Ezetimibe ›
- Levothyroxine Sodium ›
- Dexmethylphenidate ›
- Spironolactone ›
- Amoxicillin, Clavulanate Potassium ›
- Hexobarbitone ›
- Phentermine, Topiramate ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Factor 7a ›
- Levodopa ›
- Mitomycin ›
- Lenvatinib ›
- Hethylphenidate Hcl ›
- Minoxidil ›
- Cefaclor ›
- Azelaic Acid ›
- Phenylephrine ›
- Hydroxychloroquine ›
- Dirithromycin ›
- Pizotifen ›
- Vancomycin ›
- Bentoquatam ›
- Triptorelin ›
- Pentobarbitone ›
- Digoxin ›
- Procainamide ›
- Dextrothyroxine ›
- Tocainide ›
Showing the 60 most looked-up of 1,733 medications checked with no known interaction — see the full Ceylon Leadwort list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Aspirin, Caffeine, Hydrocodone Is Linked to Lower Levels of 4 Nutrients
Natural Medicines records Aspirin, Caffeine, Hydrocodone as a medicine that can lower these. This is not an interaction with Ceylon Leadwort — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Aspirin, Caffeine, Hydrocodone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Ceylon Leadwort and Aspirin, Caffeine, Hydrocodone Together: Common Questions
Can you take Ceylon Leadwort with Aspirin, Caffeine, Hydrocodone?
Why are there 4 interactions listed for Ceylon Leadwort and Aspirin, Caffeine, Hydrocodone?
How serious is the Ceylon Leadwort and Aspirin, Caffeine, Hydrocodone interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.