Medication interaction hub

What Supplements Interact with Aspirin, Caffeine, Hydrocodone?

Aspirin, Caffeine, Hydrocodone brand name: Damason-P. Every interaction below applies to the brands too.

398 Interactions 17 Major 334 Moderate 47 Minor
Curated & coded by · Clinical Pharmacist · Updated October 7, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Aspirin, Caffeine, Hydrocodone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Aspirin, Caffeine, Hydrocodone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Damason-P packs three drugs into one tablet, the opioid hydrocodone, aspirin, and caffeine, so a supplement can collide with any one of them, and its list of 398 interacting ingredients earns real respect. More than 200 of those can add to aspirin's bleeding risk, while 78 can deepen the opioid's sedation. Alcohol, whether beer or wine, is rated major for exactly that sedative pile-on and is the pairing I would rule out first.

Seventeen entries carry a major rating, with 334 moderate and 47 minor behind them, and those seventeen are worth understanding before the rest. Grapefruit can raise hydrocodone levels while St. John's wort drives them down, so the same pill can be pushed too strong or too weak depending on what sits beside it. Another 44 stimulant herbs stack on top of the caffeine, adding blood pressure and jitteriness to the mix.

— , Clinical Pharmacist · July 18, 2026

Major 17 Moderate 334 Minor 47 No known interaction 1,054

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Aspirin, Caffeine, Hydrocodone: Top Interactions at a Glance

The Aspirin, Caffeine, Hydrocodone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 398 interacting ingredients — plus 1,054 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Aspirin, Caffeine, Hydrocodone Combinations Today

The Aspirin, Caffeine, Hydrocodone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Rosemary + Aspirin, Caffeine, Hydrocodonei

Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Alpha-lipoic Acid + Aspirin, Caffeine, Hydrocodonei

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Vitamin E + Aspirin, Caffeine, Hydrocodonei

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Fasting + Aspirin, Caffeine, Hydrocodonei

Fasting may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Devil's Claw + Aspirin, Caffeine, Hydrocodonei

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Cannabis + Aspirin, Caffeine, Hydrocodonei

Theoretically, cannabis might have additive effects if used with other CNS depressants.

Read the full interaction
The complete list

Every Supplement Checked Against Aspirin, Caffeine, Hydrocodone

All 1,452 ingredients in our database, ranked by severity — 398 with a Aspirin, Caffeine, Hydrocodone interaction on file and 1,054 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Aspirin, Caffeine, Hydrocodone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Rosemary with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Rosemary + Aspirin, Caffeine, Hydrocodone answer

Can you take Alpha-lipoic Acid with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplate...

Full Alpha-lipoic Acid + Aspirin, Caffeine, Hydrocodone answer

Can you take Vitamin E with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Aspirin, Caffeine, Hydrocodone answer

Can you take Fasting with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Fasting may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Fasting + Aspirin, Caffeine, Hydrocodone answer

Can you take Devil's Claw with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Aspirin, Caffeine, Hydrocodone answer

Can you take Pagoda Tree with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pagoda tree might reduce the clearance of caffeine.

Full Pagoda Tree + Aspirin, Caffeine, Hydrocodone answer

Can you take Palm Oil with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.

Full Palm Oil + Aspirin, Caffeine, Hydrocodone answer

Can you take Panax Notoginseng with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Panax notoginseng might reduce the levels and clinical effects of CYP1A2 substrates.

Full Panax Notoginseng + Aspirin, Caffeine, Hydrocodone answer

Can you take Pantethine with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.

Full Pantethine + Aspirin, Caffeine, Hydrocodone answer

Can you take Parsley with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might increase serum levels of CYP1A2 substrates.

Full Parsley + Aspirin, Caffeine, Hydrocodone answer

Can you take Passion Flower with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.

Full Passion Flower + Aspirin, Caffeine, Hydrocodone answer

Can you take Pau D'arco with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Pau D'arco + Aspirin, Caffeine, Hydrocodone answer

Can you take Peony with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.

Full Peony + Aspirin, Caffeine, Hydrocodone answer

Can you take Peppermint with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Full Peppermint + Aspirin, Caffeine, Hydrocodone answer

Can you take Phellodendron with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase the sedative effects of CNS depressants.

Full Phellodendron + Aspirin, Caffeine, Hydrocodone answer

Can you take Phenibut with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phenibut might increase the risk of sedation and respiratory depression when taken with CNS depressants.

Full Phenibut + Aspirin, Caffeine, Hydrocodone answer

Can you take Phenpromethamine with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking phenpromethamine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effe...

Full Phenpromethamine + Aspirin, Caffeine, Hydrocodone answer

Can you take Pinellia Ternata with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research shows that a Pinellia ternata preparation decreases activity and increases sleeping time.

Full Pinellia Ternata + Aspirin, Caffeine, Hydrocodone answer

Can you take Plum with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, plum juice might have antiplatelet effects.

Full Plum + Aspirin, Caffeine, Hydrocodone answer

Can you take Policosanol with Aspirin, Caffeine, Hydrocodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.

Full Policosanol + Aspirin, Caffeine, Hydrocodone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Aspirin, Caffeine, Hydrocodone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Aspirin, Caffeine, Hydrocodone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Aspirin, Caffeine, Hydrocodone sits in 17 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Aspirin 22 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

22 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Caffeine 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Caffeine, Hydrocodone through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Aspirin, Caffeine, Hydrocodone through this category.

Related: does Aspirin, Caffeine, Hydrocodone deplete any nutrients?

Aspirin, Caffeine, Hydrocodone has 5 reported nutrient associations in the research literature — see the Aspirin, Caffeine, Hydrocodone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Aspirin, Caffeine, Hydrocodone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Aspirin, Caffeine, Hydrocodone.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Aspirin, Caffeine, Hydrocodone & Supplements: Common Questions

What supplements interact with Aspirin, Caffeine, Hydrocodone?
In our interaction database, 398 supplement and herbal ingredients have an interaction with Aspirin, Caffeine, Hydrocodone on file — 17 rated major, 334 moderate, and 47 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, Grapefruit, Siberian Cocklebur.
Which Aspirin, Caffeine, Hydrocodone supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, Siberian Cocklebur, Wine and 1,4-butanediol, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Aspirin, Caffeine, Hydrocodone?
That depends entirely on which supplement. The honest answer for Aspirin, Caffeine, Hydrocodone is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Damason-P have the same supplement interactions as Aspirin, Caffeine, Hydrocodone?
Yes — Damason-P all contain Aspirin, Caffeine, Hydrocodone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Aspirin, Caffeine, Hydrocodone deplete any vitamins or nutrients?
It might — Aspirin, Caffeine, Hydrocodone has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Aspirin, Caffeine, Hydrocodone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Aspirin, Caffeine, Hydrocodone and my other medications?
This page covers Aspirin, Caffeine, Hydrocodone against supplements and herbal ingredients. Checking Aspirin, Caffeine, Hydrocodone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 7, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.