Herb & supplement monograph

Humann Superbeets Heart Chews Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated June 2026
What is this page for?

First and foremost: how Humann Superbeets Heart Chews interacts with medications. The heart of this page is the interaction list — every drug Humann Superbeets Heart Chews is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Humann Superbeets Heart Chews is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Humann Superbeets Heart Chews Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Humann Superbeets Heart Chews drug interaction appears low for most people. Every interaction on record is rated minor, with none classified as moderate or major.

Interactions deserving the most attention

The one combination worth knowing about is with blood pressure medications. The beetroot powder in these chews contains nitrates, which can widen blood vessels and could add a small blood pressure lowering effect on top of your medication. Research consistently shows this effect is generally minor and short-lived, but if your blood pressure runs low or your dose was recently adjusted, it is reasonable to keep an eye on how you feel. Nothing else in the profile carries meaningful human evidence of harm.

What the rest of the list means

The long list of interacting medications comes almost entirely from lab studies suggesting the grape seed extract in these chews might slow enzymes the body uses to clear many drugs. That effect has been graded unlikely to occur in people, so most of these listed combinations are theoretical rather than proven problems.

Check your medications against Humann Superbeets Heart Chews

Based on HelloPharmacist’s Humann Superbeets Heart Chews interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Humann Superbeets Heart Chews

894 medications have a known interaction with Humann Superbeets Heart Chews, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
Ado-trastuzumab EmtansineKadcyla
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Ado-trastuzumab Emtansine interaction Ado-trastuzumab Emtansine drug page: uses, dosage & side effects
AbemaciclibVerzenio
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Abemaciclib interaction Abemaciclib drug page: uses, dosage & side effects
Abiraterone
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Abiraterone interaction Abiraterone drug page: uses, dosage & side effects
Abiraterone AcetateYonsa, Zytiga
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Abiraterone Acetate interaction Abiraterone Acetate drug page: uses, dosage & side effects
AcalabrutinibCalquence
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acalabrutinib interaction Acalabrutinib drug page: uses, dosage & side effects
AcebutololRhotral, Sectral
Minor Antihypertensive Drugs

Each serving of HumanN SuperBeets includes 500mg of beetroot powder (2 chews).

Read the full Humann Superbeets Heart Chews + Acebutolol interaction Acebutolol drug page: uses, dosage & side effects
AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen interaction Acetaminophen drug page: uses, dosage & side effects
Acetaminophen, AspirinGemnisyn
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Aspirin interaction
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Brompheniramine, Phenylpropanolamine interaction
Acetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Butalbital interaction
Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Butalbital, Caffeine interaction Acetaminophen, Butalbital, Caffeine drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Butalbital, CodeineBancap w/ Codeine
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Butalbital, Codeine interaction
Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
Minor Cytochrome P450 2d6 (cyp2d6) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Butalbital, Codeine Phosphate interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Minor Cytochrome P450 2d6 (cyp2d6) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Minor Cytochrome P450 2d6 (cyp2d6) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Caffeine, IsomethepteneMigralam
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Caffeine, Isometheptene interaction
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Caffeine, Pyrilamine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
Minor Cytochrome P450 3a4 (cyp3a4) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Chlorpheniramine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
Minor Cytochrome P450 2e1 (cyp2e1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Read the full Humann Superbeets Heart Chews + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Humann Superbeets Heart Chews combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Humann Superbeets Heart Chews affects

Every type of medication (drug category) Humann Superbeets Heart Chews is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 4 drug categories Humann Superbeets Heart Chews interacts with
Antihypertensive DrugsCytochrome P450 2d6 (cyp2d6) SubstratesCytochrome P450 2e1 (cyp2e1) SubstratesCytochrome P450 3a4 (cyp3a4) Substrates
Antihypertensive Drugs

Each serving of HumanN SuperBeets includes 500mg of beetroot powder (2 chews). Beetroot is rich in nitrates, which have the potential to widen blood vessels (vasodilation) and, in turn, possibly lower blood pressure. While there is a theoretical concern about the nitrate content in beets causing a blood pressure drop, research consistently indicates that any impact is generally minor and short-lived. However, it's crucial to be aware that blood pressure medications alone can cause dizziness and lightheadedness. Combining them with beet supplements might heighten the risk of experiencing these side effects due to the temporary vasodilation caused by the nitrates in beet.

Likelihood Possible Evidence A
Cytochrome P450 2D6 (Cyp2D6) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP2D6 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's crucial to highlight that, as of now, there is no documented or reported instance of this specific interaction occurring in human studies.

Likelihood Unlikely Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP2E1 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP3A4 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.

Likelihood Unlikely Evidence D
Monograph

Humann Superbeets Heart Chews: Uses, Safety & Side Effects

Medically reviewed by · Reviewed June 2026 ·
The bottom line

SuperBeets Heart Chews are a beetroot- and grape-seed-based supplement marketed to support healthy blood flow, blood pressure, and nitric oxide production. Some research on dietary nitrate from beets and on grape seed extract suggests modest cardiovascular benefits, but evidence for this specific product is limited. It is generally well tolerated, but talk with your pharmacist or doctor before using it, especially if you have heart problems or take blood pressure medicine.

Humann Superbeets Heart Chews
Part used
Beetroot (root) powder and grape seed extract
Common forms
Chewable tablets (chews)
People commonly use it for
  • Heart and cardiovascular support
  • Healthy blood pressure support
  • Nitric oxide and blood flow support
  • Antioxidant support
  • Energy and circulation

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated for most healthy adults, but check with a clinician if you have cardiovascular conditions.

PregnancyBest avoided

Safety has not been established in pregnancy, so it is best avoided unless your doctor approves.

BreastfeedingBest avoided

There is not enough safety information during breastfeeding, so avoid it unless advised otherwise.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

SuperBeets Heart Chews are a dietary supplement made by HumanN, sold as small chewable tablets. They are marketed to support heart health, healthy blood flow, and healthy blood pressure already in the normal range.

The two main ingredients are beetroot powder and a proprietary grape seed extract called Enovita. Beets are root vegetables naturally high in dietary nitrates, which the body can turn into nitric oxide. Grape seed extract is rich in plant antioxidants known as proanthocyanidins (OPCs).

People typically take the chews daily as a convenient way to add beet and grape seed compounds to their routine, often hoping to support circulation and overall cardiovascular wellness.

Uses & effectiveness

People use SuperBeets Heart Chews mainly for heart health, blood pressure support, and improved blood flow. These uses are based on the individual ingredients rather than on large studies of the finished product itself.

There is some scientific support for the ingredients. Dietary nitrate from beetroot has been studied for modest, short-term effects on blood pressure and exercise performance in some people. Grape seed extract has been studied for small effects on blood pressure and as an antioxidant. However, results across studies are mixed, effects tend to be modest, and study designs and doses vary.

Importantly, high-quality independent research specifically on SuperBeets Heart Chews is limited. The supplement is not a treatment for high blood pressure, heart disease, or any other medical condition, and it should not replace prescribed medicines or proven lifestyle changes.

How it works

The proposed main mechanism comes from nitrates in beetroot. After you eat them, bacteria in your mouth and your body help convert nitrate to nitrite and then to nitric oxide. Nitric oxide is a signaling molecule that helps blood vessels relax and widen, which may support healthy blood flow and blood pressure.

The grape seed extract (Enovita) provides proanthocyanidins (OPCs), which act as antioxidants. Antioxidants may help protect cells from oxidative stress, and some lab and small human studies suggest grape seed compounds may support blood vessel function.

Much of the supporting science comes from laboratory studies, animal research, and small human trials. These mechanisms are promising but do not guarantee meaningful results for any one person.

Safety & precautions

For most healthy adults, beetroot and grape seed extract are generally considered well tolerated when used as directed. Still, there are a few cautions.

If you have low blood pressure, take blood pressure medicines, or have any heart or kidney condition, talk with your pharmacist or doctor before starting, since the product may affect blood pressure. People with a history of kidney stones may want to be cautious because beets contain oxalates.

Because safety has not been established, pregnant and breastfeeding people should avoid this product unless a doctor specifically approves it. Do not give it to children unless directed by a healthcare provider.

Supplements are not tightly regulated like prescription drugs, so quality can vary between brands. Always read the label and check with a pharmacist if you are unsure.

Side effects

Side effects are usually mild. Beetroot can cause harmless reddish or pink urine or stool (called beeturia), which can be alarming but is not dangerous. Some people may notice stomach upset or digestive changes.

Because the ingredients may lower blood pressure, some people could feel lightheaded or dizzy, especially if their blood pressure is already low. Allergic reactions are uncommon but possible.

If you have a serious reaction such as trouble breathing, swelling, fainting, or a very rapid or irregular heartbeat, stop using the product and seek medical care.

Dosing

There is no official standardized dose for this product or its ingredients. The best approach is to follow the directions on the package label, which typically suggests a set number of chews per day.

Do not take more than the label recommends in hopes of stronger effects. If you are unsure how it fits with your health conditions or medicines, check with your pharmacist or doctor before starting and before increasing the amount.

References & further reading

The 2 sources that drive our Humann Superbeets Heart Chews monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.

  1. Grape Seed Extract — NIH NCCIH Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Pharmacist Counseling Corner

Humann Superbeets Heart Chews: Common Questions

Does Humann Superbeets Heart Chews interact with prescription medications?
Yes. We list 894 medications with a known interaction with Humann Superbeets Heart Chews. Use the checker above to see how Humann Superbeets Heart Chews interacts with a specific drug.
How are Humann Superbeets Heart Chews interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Humann Superbeets Heart Chews with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Humann Superbeets Heart Chews interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What are SuperBeets Heart Chews used for?
They are marketed to support heart health, healthy blood flow, nitric oxide production, and blood pressure already in the normal range, using beetroot powder and grape seed extract.
Do SuperBeets Heart Chews actually lower blood pressure?
Some research on beet nitrate and grape seed extract shows modest blood pressure effects, but evidence for this specific product is limited and results vary. It is not a substitute for prescribed blood pressure treatment.
Are SuperBeets Heart Chews safe to take every day?
Most healthy adults tolerate them well when used as directed, but you should check with your pharmacist or doctor first if you have heart, kidney, or blood pressure conditions.
Why is my urine pink or red after taking them?
Beetroot can turn urine or stool a reddish or pink color, a harmless effect called beeturia. It is not a sign of bleeding or harm.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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