Desipramine

Desipramine is used to treat depression. Desipramine is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed for mental balance.

Desipramine comes as a tablet to take by mouth. It is usually taken one or more times a day and may be taken with or without food. Take desipramine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take desipramine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may start you on a low dose of desipramine and gradually increase your dose.

It may take 2 to 3 weeks for you to feel the full benefit of desipramine. Continue to take desipramine even if you feel well. Do not stop taking desipramine without talking to your doctor. If you suddenly stop taking desipramine, you may experience withdrawal symptoms such as nausea, headache, and weakness. Your doctor will probably want to decrease your dose gradually.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking desipramine,

• tell your doctor and pharmacist if you are allergic to desipramine, clomipramine (Anafranil), imipramine (Tofranil), trimipramine (Surmontil), any other medications, or any of the ingredients in desipramine tablets. Ask your doctor or pharmacist for a list of the ingredients.

• tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Your doctor will probably tell you not to take desipramine. If you stop taking desipramine, you should wait at least 14 days before you start to take an MAO inhibitor.

• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, herbal products and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants (blood thinners) such as warfarin (Coumadin); antihistamines; cimetidine (Tagamet); estrogens; flecainide (Tambocor); fluoxetine (Prozac); guanethidine (Ismelin); levodopa (Sinemet, Larodopa); lithium (Eskalith, Lithobid); medication for high blood pressure, seizures, Parkinson's disease, diabetes, mental illness, nausea, asthma, colds, or allergies; methylphenidate (Ritalin); muscle relaxants; oral contraceptives; phenobarbital; propafenone (Rythmol); quinidine; sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); sleeping pills; thyroid medications; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Your doctor may tell you not to take desipramine if you have stopped taking fluoxetine during the past 5 weeks.

• tell your doctor if you have recently had a heart attack. Your doctor may tell you that you should not take desipramine.

• tell your doctor if anyone in your family has or has ever had an irregular heartbeat or has died suddenly. Also tell your doctor if you have or have ever had heart or blood vessel disease such as high blood pressure, atherosclerosis (hardening of the arteries), angina (chest pain), irregular heartbeat, or a heart attack; an enlarged prostate (a male reproductive gland) difficulty urinating; diabetes; seizures; an overactive thyroid gland; schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions); or liver or kidney disease.

• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking desipramine, call your doctor.

• talk to your doctor about the risks and benefits of taking desipramine if you are 65 years of age or older. Older adults should not usually take desipramine because it is not as safe or effective as other medications that can be used to treat the same condition.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking desipramine.

• you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

• ask your doctor about the safe use of alcohol while you are taking this medication.

• tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication.

• you should know that desipramine may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Desipramine may cause side effects. Call your doctor if any of these symptoms become severe or do not go away:

  • nausea

  • drowsiness

  • weakness or tiredness

  • nightmares

  • dry mouth

  • skin more sensitive to sunlight than usual

  • changes in appetite or weight

  • constipation

  • difficulty urinating

  • frequent urination

  • changes in sex drive or ability

  • excessive sweating

• Some side effects can be serious. If you experience any of the following symptoms, or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:

  • jaw, neck, and back muscle spasms

  • slow or difficult speech

  • shuffling walk

  • uncontrollable shaking or movement of a part of the body

  • fever

  • difficulty breathing or swallowing

  • severe rash

  • yellowing of the skin or eyes

  • irregular heartbeat

  • seizures

  • sore throat, fever, and other signs of infection

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of the reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

• irregular heartbeat

• seizures

• coma (loss of consciousness for a period of time)

• confusion

• hallucination (seeing things that do not exist)

• widened pupils (dark circles in the middle of the eyes)

• drowsiness

• agitation

• fever

• low body temperature

• stiff muscles

• vomiting

Keep all appointments with your doctor.

Do not allow anyone else to take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Moxifloxacin	Moxifloxacin The risk or severity of QTc prolongation can be increased when Desipramine is combined with Moxifloxacin.
Repaglinide	Repaglinide Desipramine may decrease the hypoglycemic activities of Repaglinide.
Insulin Glargine (rDNA origin) Injection	Insulin Glargine (rDNA origin) Injection Desipramine may decrease the hypoglycemic activities of Insulin glargine.
Delavirdine	Delavirdine The metabolism of Desipramine can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Desipramine can be decreased when combined with Nevirapine.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Desipramine.
Dolasetron	Dolasetron The metabolism of Desipramine can be decreased when combined with Dolasetron.
Aminophylline	Aminophylline The metabolism of Aminophylline can be decreased when combined with Desipramine.
Anagrelide	Anagrelide The risk or severity of QTc prolongation can be increased when Desipramine is combined with Anagrelide.
Bisacodyl	Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Desipramine.
Candesartan	Candesartan Desipramine may decrease the antihypertensive activities of Candesartan.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Desipramine.
Clopidogrel	Clopidogrel The metabolism of Desipramine can be decreased when combined with Clopidogrel.
Diphenoxylate	Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Desipramine.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The risk or severity of QTc prolongation can be increased when Desipramine is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Desipramine which could result in a higher serum level.
Fenofibrate	Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Desipramine.
Guanfacine	Guanfacine Desipramine may increase the central nervous system depressant (CNS depressant) activities of Guanfacine.
Magnesium Hydroxide	Magnesium Hydroxide The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Desipramine.
Magnesium Oxide	Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Desipramine.
Methylergonovine	Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Desipramine.
Miglitol	Miglitol Desipramine may decrease the hypoglycemic activities of Miglitol.
Mycophenolate	Mycophenolate Mycophenolic acid may decrease the excretion rate of Desipramine which could result in a higher serum level.
Naratriptan	Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Desipramine.
Olsalazine	Olsalazine Desipramine may decrease the excretion rate of Olsalazine which could result in a higher serum level.
Paregoric	Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Desipramine.
Penbutolol	Penbutolol The metabolism of Desipramine can be decreased when combined with Acebutolol.
Pentazocine	Pentazocine The risk or severity of adverse effects can be increased when Desipramine is combined with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES)	Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Desipramine.
Potassium	Potassium Potassium may increase the excretion rate of Desipramine which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone	Prednisone Prednisone may decrease the excretion rate of Desipramine which could result in a higher serum level.
Psyllium	Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Desipramine.
Ranitidine	Ranitidine The metabolism of Ranitidine can be decreased when combined with Desipramine.
Reserpine	Reserpine Desipramine may increase the central nervous system depressant (CNS depressant) activities of Reserpine.
Rizatriptan	Rizatriptan Rizatriptan may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Sumatriptan	Sumatriptan Sumatriptan may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Tacrolimus	Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Desipramine.
Tizanidine	Tizanidine Tizanidine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Zolmitriptan	Zolmitriptan Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Ampicillin Injection	Ampicillin Injection Ampicillin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Doxycycline Injection	Doxycycline Injection Doxycycline may decrease the excretion rate of Desipramine which could result in a higher serum level.
Famotidine Injection	Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Desipramine.
Fluconazole Injection	Fluconazole Injection The risk or severity of QTc prolongation can be increased when Fluconazole is combined with Desipramine.
Foscarnet Injection	Foscarnet Injection The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Desipramine.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Desipramine.
Levofloxacin Injection	Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Desipramine is combined with Levofloxacin.
Meperidine Injection	Meperidine Injection The metabolism of Meperidine can be decreased when combined with Desipramine.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Desipramine.
Metronidazole Injection	Metronidazole Injection The risk or severity of QTc prolongation can be increased when Metronidazole is combined with Desipramine.
Morphine Injection	Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Desipramine.
Pamidronate Injection	Pamidronate Injection Pamidronic acid may decrease the excretion rate of Desipramine which could result in a higher serum level.
Vancomycin Injection	Vancomycin Injection Desipramine may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine	Altretamine Amphetamine may decrease the sedative and stimulatory activities of Desipramine.
Cefuroxime	Cefuroxime Cefuroxime may decrease the excretion rate of Desipramine which could result in a higher serum level.
Cyclosporine	Cyclosporine The metabolism of Desipramine can be decreased when combined with Cyclosporine.
Ondansetron	Ondansetron The metabolism of Desipramine can be decreased when combined with Ondansetron.
Granisetron	Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Desipramine.
Torsemide	Torsemide Torasemide may increase the excretion rate of Desipramine which could result in a lower serum level and potentially a reduction in efficacy.
Alosetron	Alosetron Alosetron may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Dofetilide	Dofetilide The metabolism of Dofetilide can be decreased when combined with Desipramine.
Entacapone	Entacapone The metabolism of Desipramine can be decreased when combined with Entacapone.
Eprosartan	Eprosartan Desipramine may decrease the antihypertensive activities of Eprosartan.
Hydroxychloroquine	Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Desipramine.
Meloxicam	Meloxicam Meloxicam may decrease the excretion rate of Desipramine which could result in a higher serum level.
Oxcarbazepine	Oxcarbazepine Oxcarbazepine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Pantoprazole	Pantoprazole Pantoprazole may decrease the excretion rate of Desipramine which could result in a higher serum level.
Telmisartan	Telmisartan Desipramine may decrease the antihypertensive activities of Telmisartan.
Temozolomide	Temozolomide Temozolomide may decrease the excretion rate of Desipramine which could result in a higher serum level.
Zaleplon	Zaleplon Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Anakinra	Anakinra The metabolism of Desipramine can be increased when combined with Anakinra.
Desloratadine	Desloratadine Desipramine may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.
Linezolid	Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Desipramine.
Rivastigmine	Rivastigmine The therapeutic efficacy of Desipramine can be decreased when used in combination with Rivastigmine.
Trimipramine	Trimipramine The metabolism of Desipramine can be decreased when combined with Trimipramine.
Etanercept Injection	Etanercept Injection The metabolism of Desipramine can be increased when combined with Etanercept.
Glycopyrrolate	Glycopyrrolate The risk or severity of adverse effects can be increased when Desipramine is combined with Glycopyrronium.
Modafinil	Modafinil The metabolism of Desipramine can be decreased when combined with Modafinil.
Perindopril	Perindopril Desipramine may decrease the antihypertensive activities of Perindopril.
Tenofovir	Tenofovir The metabolism of Tenofovir can be decreased when combined with Desipramine.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate Desipramine may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.
Sirolimus	Sirolimus The metabolism of Sirolimus can be decreased when combined with Desipramine.
Dutasteride	Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Desipramine.
Epinephrine Injection	Epinephrine Injection Desipramine may increase the vasopressor activities of Epinephrine.
Eplerenone	Eplerenone Desipramine may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram	Escitalopram The risk or severity of serotonin syndrome can be increased when Desipramine is combined with Escitalopram.
Olmesartan	Olmesartan Desipramine may decrease the antihypertensive activities of Olmesartan.
Zonisamide	Zonisamide Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Adalimumab Injection	Adalimumab Injection The metabolism of Desipramine can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Desipramine.
Atomoxetine	Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Desipramine.
Dexmethylphenidate	Dexmethylphenidate The serum concentration of Desipramine can be increased when it is combined with Dexmethylphenidate.
Atazanavir	Atazanavir The risk or severity of QTc prolongation can be increased when Atazanavir is combined with Desipramine.
Almotriptan	Almotriptan The metabolism of Desipramine can be decreased when combined with Almotriptan.
Eletriptan	Eletriptan The metabolism of Eletriptan can be decreased when combined with Desipramine.
Mefloquine	Mefloquine The metabolism of Desipramine can be decreased when combined with Mefloquine.
Polyethylene Glycol 3350	Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Desipramine.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Desipramine.
Vardenafil	Vardenafil The metabolism of Vardenafil can be decreased when combined with Desipramine.
Alfuzosin	Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Desipramine.
Emtricitabine	Emtricitabine Emtricitabine may decrease the excretion rate of Desipramine which could result in a higher serum level.
Memantine	Memantine The metabolism of Desipramine can be decreased when combined with Memantine.
Tegaserod	Tegaserod The metabolism of Desipramine can be decreased when combined with Tegaserod.
Tadalafil	Tadalafil Desipramine may decrease the antihypertensive activities of Tadalafil.
Frovatriptan	Frovatriptan Frovatriptan may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Gemifloxacin	Gemifloxacin The risk or severity of QTc prolongation can be increased when Desipramine is combined with Gemifloxacin.
Progesterone	Progesterone The metabolism of Desipramine can be decreased when combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Desipramine.
Infliximab Injection	Infliximab Injection The metabolism of Desipramine can be increased when combined with Infliximab.
Protriptyline	Protriptyline The metabolism of Desipramine can be decreased when combined with Protriptyline.
Duloxetine	Duloxetine The metabolism of Desipramine can be decreased when combined with Duloxetine.
Norethindrone	Norethindrone The metabolism of Norethisterone can be decreased when combined with Desipramine.
Tinidazole	Tinidazole Tinidazole may decrease the excretion rate of Desipramine which could result in a higher serum level.
Trospium	Trospium The metabolism of Trospium can be decreased when combined with Desipramine.
Bosentan	Bosentan Desipramine may decrease the antihypertensive activities of Bosentan.
Cefditoren	Cefditoren Cefdinir may decrease the excretion rate of Desipramine which could result in a higher serum level.
Cinacalcet	Cinacalcet The metabolism of Desipramine can be decreased when combined with Cinacalcet.
Cyanocobalamin Injection	Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Erlotinib	Erlotinib The metabolism of Desipramine can be decreased when combined with Erlotinib.
Eszopiclone	Eszopiclone The risk or severity of CNS depression can be increased when Desipramine is combined with Eszopiclone.
Ganciclovir	Ganciclovir The risk or severity of adverse effects can be increased when Ganciclovir is combined with Desipramine.
Insulin Aspart (rDNA Origin) Injection	Insulin Aspart (rDNA Origin) Injection Desipramine may decrease the hypoglycemic activities of Insulin aspart.
Ribavirin	Ribavirin Ribavirin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Solifenacin	Solifenacin The metabolism of Desipramine can be decreased when combined with Solifenacin.
Valganciclovir	Valganciclovir Desipramine may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole	Voriconazole The risk or severity of QTc prolongation can be increased when Voriconazole is combined with Desipramine.
Adefovir	Adefovir Adefovir may decrease the excretion rate of Desipramine which could result in a higher serum level.
Dextroamphetamine	Dextroamphetamine Amphetamine may decrease the sedative and stimulatory activities of Desipramine.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The metabolism of Desipramine can be decreased when combined with Peginterferon alfa-2b.
Pramlintide Injection	Pramlintide Injection The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Desipramine.
Sodium Oxybate	Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Exenatide Injection	Exenatide Injection Desipramine may decrease the hypoglycemic activities of Exenatide.
Ibandronate	Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Desipramine.
Isocarboxazid	Isocarboxazid Desipramine may increase the serotonergic activities of Isocarboxazid.
Ramelteon	Ramelteon Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Darifenacin	Darifenacin The metabolism of Darifenacin can be decreased when combined with Desipramine.
Fentanyl	Fentanyl The metabolism of Fentanyl can be decreased when combined with Desipramine.
Pregabalin	Pregabalin The therapeutic efficacy of Desipramine can be increased when used in combination with Pregabalin.
Phenylephrine	Phenylephrine Desipramine may increase the vasopressor activities of Phenylephrine.
Tipranavir	Tipranavir The metabolism of Tipranavir can be decreased when combined with Desipramine.
Felbamate	Felbamate Felbamate may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Insulin Detemir (rDNA Origin) Injection	Insulin Detemir (rDNA Origin) Injection Desipramine may decrease the hypoglycemic activities of Insulin detemir.
Ranolazine	Ranolazine The serum concentration of Desipramine can be increased when it is combined with Ranolazine.
Abatacept Injection	Abatacept Injection The metabolism of Desipramine can be increased when combined with Abatacept.
Rasagiline	Rasagiline Rasagiline may increase the serotonergic activities of Desipramine.
Imatinib	Imatinib The metabolism of Desipramine can be decreased when combined with Imatinib.
Sitagliptin	Sitagliptin Desipramine may decrease the hypoglycemic activities of Sitagliptin.
Varenicline	Varenicline The excretion of Varenicline can be decreased when combined with Desipramine.
Gefitinib	Gefitinib The metabolism of Desipramine can be decreased when combined with Gefitinib.
Albuterol	Albuterol The risk or severity of hypertension can be increased when Salbutamol is combined with Desipramine.
Paliperidone	Paliperidone The metabolism of Paliperidone can be decreased when combined with Desipramine.
Bortezomib	Bortezomib The metabolism of Desipramine can be decreased when combined with Bortezomib.
Clofarabine Injection	Clofarabine Injection The serum concentration of Desipramine can be increased when it is combined with Clofarabine.
Insulin Glulisine (rDNA origin) Injection	Insulin Glulisine (rDNA origin) Injection Desipramine may decrease the hypoglycemic activities of Insulin glulisine.
Lubiprostone	Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Desipramine.
Oxaliplatin Injection	Oxaliplatin Injection The serum concentration of Oxaliplatin can be increased when it is combined with Desipramine.
Posaconazole	Posaconazole The risk or severity of QTc prolongation can be increased when Desipramine is combined with Posaconazole.
Primaquine	Primaquine The metabolism of Desipramine can be decreased when combined with Primaquine.
Aliskiren	Aliskiren Desipramine may decrease the antihypertensive activities of Aliskiren.
Bismuth Subsalicylate	Bismuth Subsalicylate Desipramine may increase the neurotoxic activities of Bismuth subsalicylate.
Pemetrexed Injection	Pemetrexed Injection Pemetrexed may decrease the excretion rate of Desipramine which could result in a higher serum level.
Dimenhydrinate	Dimenhydrinate Dimenhydrinate may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Lisdexamfetamine	Lisdexamfetamine Lisdexamfetamine may decrease the sedative and stimulatory activities of Desipramine.
Nabilone	Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Retapamulin	Retapamulin The metabolism of Retapamulin can be decreased when combined with Desipramine.
Vorinostat	Vorinostat The risk or severity of QTc prolongation can be increased when Desipramine is combined with Vorinostat.
Sorafenib	Sorafenib The metabolism of Desipramine can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib The metabolism of Sunitinib can be decreased when combined with Desipramine.
Dronabinol	Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Lapatinib	Lapatinib The risk or severity of QTc prolongation can be increased when Desipramine is combined with Lapatinib.
Levocetirizine	Levocetirizine Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Pegaptanib Injection	Pegaptanib Injection Desipramine may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib	Dasatinib The metabolism of Dasatinib can be decreased when combined with Desipramine.
Mexiletine	Mexiletine The metabolism of Desipramine can be decreased when combined with Mexiletine.
Armodafinil	Armodafinil The metabolism of Desipramine can be increased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection Azacitidine may decrease the excretion rate of Desipramine which could result in a higher serum level.
Paclitaxel (with polyoxyethylated castor oil) Injection	Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Desipramine.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Desipramine.
Lenalidomide	Lenalidomide Lenalidomide may decrease the excretion rate of Desipramine which could result in a higher serum level.
Nilotinib	Nilotinib The metabolism of Desipramine can be decreased when combined with Nilotinib.
Toremifene	Toremifene The risk or severity of QTc prolongation can be increased when Desipramine is combined with Toremifene.
Budesonide	Budesonide Desipramine may decrease the excretion rate of Budesonide which could result in a higher serum level.
Desmopressin	Desmopressin The risk or severity of hyponatremia and water intoxication can be increased when Desipramine is combined with Desmopressin.
Betaine	Betaine The therapeutic efficacy of Desipramine can be decreased when used in combination with Glycine betaine.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Desipramine is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Desipramine is combined with Botulinum Toxin Type B.
Doripenem Injection	Doripenem Injection Desipramine may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Desipramine is combined with Arsenic trioxide.
Desvenlafaxine	Desvenlafaxine The metabolism of Desvenlafaxine can be decreased when combined with Desipramine.
Cevimeline	Cevimeline The metabolism of Desipramine can be decreased when combined with Cevimeline.
Nebivolol	Nebivolol The metabolism of Desipramine can be decreased when combined with Nebivolol.
Tretinoin	Tretinoin The metabolism of Desipramine can be decreased when combined with Tretinoin.
Flecainide	Flecainide The metabolism of Flecainide can be decreased when combined with Desipramine.
Certolizumab Injection	Certolizumab Injection The metabolism of Certolizumab pegol can be increased when combined with Desipramine.
Ixabepilone Injection	Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Desipramine.
Irinotecan Injection	Irinotecan Injection The metabolism of Desipramine can be decreased when combined with Irinotecan.
Daptomycin Injection	Daptomycin Injection Daptomycin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Methylnaltrexone Injection	Methylnaltrexone Injection Desipramine may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide	Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Desipramine.
Midazolam	Midazolam The serum concentration of Midazolam can be increased when it is combined with Desipramine.
Naltrexone Injection	Naltrexone Injection The risk or severity of adverse effects can be increased when Naltrexone is combined with Desipramine.
Dexrazoxane Injection	Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Desipramine which could result in a higher serum level.
Milnacipran	Milnacipran The risk or severity of adverse effects can be increased when Desipramine is combined with Milnacipran.
Plerixafor Injection	Plerixafor Injection Desipramine may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate	Sodium Phosphate The risk or severity of seizure can be increased when Desipramine is combined with Sodium phosphate, monobasic.
Fesoterodine	Fesoterodine The metabolism of Desipramine can be decreased when combined with Fesoterodine.
Degarelix Injection	Degarelix Injection The risk or severity of QTc prolongation can be increased when Desipramine is combined with Degarelix.
Betaxolol	Betaxolol The metabolism of Desipramine can be decreased when combined with Betaxolol.
Iloperidone	Iloperidone The metabolism of Iloperidone can be decreased when combined with Desipramine.
Prasugrel	Prasugrel The metabolism of Prasugrel can be decreased when combined with Desipramine.
Lacosamide	Lacosamide Desipramine may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Everolimus	Everolimus The metabolism of Everolimus can be decreased when combined with Desipramine.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The metabolism of Desipramine can be decreased when combined with Tolvaptan.
Dronedarone	Dronedarone Desipramine may increase the QTc-prolonging activities of Dronedarone.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Desipramine is combined with Botulinum toxin type A.
Pralatrexate Injection	Pralatrexate Injection Desipramine may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection	Palonosetron Injection The metabolism of Desipramine can be decreased when combined with Palonosetron.
Saxagliptin	Saxagliptin Desipramine may decrease the hypoglycemic activities of Saxagliptin.
Telavancin Injection	Telavancin Injection The risk or severity of QTc prolongation can be increased when Desipramine is combined with Telavancin.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Desipramine.
Tapentadol	Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Topotecan	Topotecan Topotecan may decrease the excretion rate of Desipramine which could result in a higher serum level.
Golimumab Injection	Golimumab Injection The metabolism of Desipramine can be increased when combined with Golimumab.
Pazopanib	Pazopanib The metabolism of Desipramine can be decreased when combined with Pazopanib.
Asenapine	Asenapine The risk or severity of adverse effects can be increased when Desipramine is combined with Asenapine.
Vigabatrin	Vigabatrin Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Albendazole	Albendazole The metabolism of Albendazole can be decreased when combined with Desipramine.
Oxymorphone	Oxymorphone The metabolism of Desipramine can be decreased when combined with Oxymorphone.
Liraglutide Injection	Liraglutide Injection Desipramine may decrease the hypoglycemic activities of Liraglutide.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Desipramine can be increased when combined with Tocilizumab.
Dalfampridine	Dalfampridine The risk or severity of seizure can be increased when Desipramine is combined with Dalfampridine.
Fingolimod	Fingolimod The metabolism of Fingolimod can be decreased when combined with Desipramine.
Eribulin Injection	Eribulin Injection The risk or severity of QTc prolongation can be increased when Desipramine is combined with Eribulin.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Desipramine is combined with Botulinum toxin type A.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Desipramine.
Ceftaroline Injection	Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Desipramine which could result in a higher serum level.
Lurasidone	Lurasidone Lurasidone may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Acetaminophen Injection	Acetaminophen Injection Desipramine may increase the hepatotoxic activities of Acetaminophen.
Vilazodone	Vilazodone The metabolism of Vilazodone can be decreased when combined with Desipramine.
Ipilimumab Injection	Ipilimumab Injection Desipramine may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection	Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Terbutaline Injection	Terbutaline Injection The risk or severity of hypertension can be increased when Terbutaline is combined with Desipramine.
Busulfan Injection	Busulfan Injection The metabolism of Busulfan can be decreased when combined with Desipramine.
Roflumilast	Roflumilast The metabolism of Roflumilast can be decreased when combined with Desipramine.
Linagliptin	Linagliptin Desipramine may decrease the hypoglycemic activities of Linagliptin.
Rilpivirine	Rilpivirine The metabolism of Rilpivirine can be decreased when combined with Desipramine.
Potassium Iodide	Potassium Iodide The risk or severity of Cardiac Arrhythmia can be increased when Potassium Iodide is combined with Desipramine.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Desipramine.
Abiraterone	Abiraterone The metabolism of Desipramine can be decreased when combined with Abiraterone.
Triptorelin Injection	Triptorelin Injection The risk or severity of QTc prolongation can be increased when Desipramine is combined with Triptorelin.
Rivaroxaban	Rivaroxaban Desipramine may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The metabolism of Desipramine can be decreased when combined with Brentuximab vedotin.
Ruxolitinib	Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Desipramine.
Vandetanib	Vandetanib The metabolism of Vandetanib can be decreased when combined with Desipramine.
Clobazam	Clobazam The metabolism of Desipramine can be decreased when combined with Clobazam.
Vemurafenib	Vemurafenib The risk or severity of QTc prolongation can be increased when Desipramine is combined with Vemurafenib.
Deferiprone	Deferiprone Desipramine may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Desipramine.
Crizotinib	Crizotinib The metabolism of Crizotinib can be decreased when combined with Desipramine.
Cabergoline	Cabergoline The metabolism of Desipramine can be decreased when combined with Cabergoline.
Naloxone Injection	Naloxone Injection Desipramine may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ambrisentan	Ambrisentan Desipramine may decrease the antihypertensive activities of Ambrisentan.
Fondaparinux Injection	Fondaparinux Injection Fondaparinux may decrease the excretion rate of Desipramine which could result in a higher serum level.
Ezogabine	Ezogabine Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Enzalutamide	Enzalutamide The metabolism of Enzalutamide can be decreased when combined with Desipramine.
Mirabegron	Mirabegron The risk or severity of urinary retention can be increased when Mirabegron is combined with Desipramine.
Regorafenib	Regorafenib The metabolism of Desipramine can be decreased when combined with Regorafenib.
Bosutinib	Bosutinib The metabolism of Desipramine can be decreased when combined with Bosutinib.
Linaclotide	Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Desipramine.
Lorcaserin	Lorcaserin Desipramine may decrease the hypoglycemic activities of Mecasermin.
Teduglutide Injection	Teduglutide Injection Desipramine may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Bedaquiline	Bedaquiline The risk or severity of QTc prolongation can be increased when Desipramine is combined with Bedaquiline.
Tofacitinib	Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Desipramine.
Alogliptin	Alogliptin The metabolism of Desipramine can be decreased when combined with Alogliptin.
Ponatinib	Ponatinib The metabolism of Desipramine can be decreased when combined with Ponatinib.
Pomalidomide	Pomalidomide The metabolism of Desipramine can be decreased when combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Desipramine.
Canagliflozin	Canagliflozin Desipramine may decrease the hypoglycemic activities of Canagliflozin.
Methazolamide	Methazolamide Methazolamide may increase the excretion rate of Desipramine which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib	Dabrafenib The metabolism of Desipramine can be decreased when combined with Dabrafenib.
Ospemifene	Ospemifene The metabolism of Ospemifene can be decreased when combined with Desipramine.
Trametinib	Trametinib Desipramine may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran	Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Desipramine.
Ertapenem Injection	Ertapenem Injection Ertapenem may decrease the excretion rate of Desipramine which could result in a higher serum level.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Desipramine.
Perampanel	Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Desipramine.
Lomitapide	Lomitapide The metabolism of Desipramine can be decreased when combined with Lomitapide.
Ketorolac Injection	Ketorolac Injection Ketorolac may decrease the excretion rate of Desipramine which could result in a higher serum level.
Sofosbuvir	Sofosbuvir Desipramine may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin	Dapagliflozin The metabolism of Desipramine can be decreased when combined with Dapagliflozin.
Apremilast	Apremilast The metabolism of Apremilast can be increased when combined with Desipramine.
Droxidopa	Droxidopa Desipramine may increase the vasopressor activities of Droxidopa.
Ceritinib	Ceritinib The metabolism of Desipramine can be decreased when combined with Ceritinib.
Siltuximab Injection	Siltuximab Injection The metabolism of Desipramine can be increased when combined with Siltuximab.
Albiglutide Injection	Albiglutide Injection Desipramine may decrease the hypoglycemic activities of Albiglutide.
Eslicarbazepine	Eslicarbazepine Eslicarbazepine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Idelalisib	Idelalisib The metabolism of Idelalisib can be decreased when combined with Desipramine.
Testosterone Injection	Testosterone Injection Testosterone may decrease the excretion rate of Desipramine which could result in a higher serum level.
Oritavancin Injection	Oritavancin Injection The metabolism of Desipramine can be decreased when combined with Oritavancin.
Empagliflozin	Empagliflozin Desipramine may decrease the hypoglycemic activities of Empagliflozin.
Vorapaxar	Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Desipramine.
Hydrocodone	Hydrocodone Desipramine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant	Suvorexant Desipramine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Dulaglutide Injection	Dulaglutide Injection Desipramine may decrease the hypoglycemic activities of Dulaglutide.
Edoxaban	Edoxaban Desipramine may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Olaparib	Olaparib The metabolism of Desipramine can be decreased when combined with Olaparib.
Methamphetamine	Methamphetamine Metamfetamine may decrease the sedative and stimulatory activities of Desipramine.
Tasimelteon	Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Desipramine.
Riociguat	Riociguat Desipramine may decrease the antihypertensive activities of Riociguat.
Nintedanib	Nintedanib The metabolism of Nintedanib can be decreased when combined with Desipramine.
Secukinumab Injection	Secukinumab Injection The metabolism of Desipramine can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The metabolism of Desipramine can be decreased when combined with Risperidone.
Palbociclib	Palbociclib The metabolism of Desipramine can be decreased when combined with Palbociclib.
Insulin Human Inhalation	Insulin Human Inhalation Desipramine may decrease the hypoglycemic activities of Insulin human.
Lenvatinib	Lenvatinib The metabolism of Lenvatinib can be decreased when combined with Desipramine.
Naloxegol	Naloxegol The metabolism of Desipramine can be decreased when combined with Naloxegol.
Panobinostat	Panobinostat The metabolism of Desipramine can be decreased when combined with Panobinostat.
Haloperidol Injection	Haloperidol Injection The serum concentration of Desipramine can be increased when it is combined with Haloperidol.
Ivabradine	Ivabradine The risk or severity of QTc prolongation can be increased when Desipramine is combined with Ivabradine.
Amiloride	Amiloride Amiloride may increase the excretion rate of Desipramine which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan	Macitentan Desipramine may decrease the antihypertensive activities of Macitentan.
Sonidegib	Sonidegib The metabolism of Sonidegib can be decreased when combined with Desipramine.
Flibanserin	Flibanserin The risk or severity of adverse effects can be increased when Desipramine is combined with Flibanserin.
Rolapitant	Rolapitant The metabolism of Desipramine can be decreased when combined with Rolapitant.
Brexpiprazole	Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Desipramine.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Desipramine.
Cariprazine	Cariprazine The metabolism of Cariprazine can be decreased when combined with Desipramine.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Desipramine may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline	Eluxadoline The risk or severity of constipation can be increased when Desipramine is combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection	Insulin Degludec (rDNA Origin) Injection Desipramine may decrease the hypoglycemic activities of Insulin degludec.
Cobimetinib	Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Desipramine.
Trabectedin Injection	Trabectedin Injection The metabolism of Desipramine can be decreased when combined with Trabectedin.
Osimertinib	Osimertinib The metabolism of Osimertinib can be decreased when combined with Desipramine.
Alectinib	Alectinib The metabolism of Alectinib can be decreased when combined with Desipramine.
Ixazomib	Ixazomib The metabolism of Ixazomib can be decreased when combined with Desipramine.
Rifapentine	Rifapentine The metabolism of Desipramine can be increased when combined with Rifapentine.
Lesinurad	Lesinurad Desipramine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Desipramine which could result in a higher serum level.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Desipramine can be increased when combined with Dexamethasone.
Brivaracetam Injection	Brivaracetam Injection Brivaracetam may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Venetoclax	Venetoclax The metabolism of Desipramine can be decreased when combined with Venetoclax.
Cobicistat	Cobicistat The metabolism of Desipramine can be decreased when combined with Cobicistat.
Midodrine	Midodrine Midodrine may increase the vasopressor activities of Desipramine.
Selexipag	Selexipag Desipramine may decrease the antihypertensive activities of Selexipag.
Pimavanserin	Pimavanserin The risk or severity of adverse effects can be increased when Desipramine is combined with Pimavanserin.
Diphenhydramine Injection	Diphenhydramine Injection The metabolism of Desipramine can be decreased when combined with Diphenhydramine.
Furosemide Injection	Furosemide Injection Desipramine may decrease the excretion rate of Furosemide which could result in a higher serum level.
Rucaparib	Rucaparib The metabolism of Desipramine can be decreased when combined with Rucaparib.
Lixisenatide Injection	Lixisenatide Injection Desipramine may decrease the hypoglycemic activities of Lixisenatide.
Ribociclib	Ribociclib The risk or severity of QTc prolongation can be increased when Desipramine is combined with Ribociclib.
Brigatinib	Brigatinib The metabolism of Desipramine can be decreased when combined with Brigatinib.
Doxepin (Insomnia)	Doxepin (Insomnia) The metabolism of Desipramine can be decreased when combined with Doxepin.
Plecanatide	Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Desipramine.
Deutetrabenazine	Deutetrabenazine The metabolism of Desipramine can be decreased when combined with Deutetrabenazine.
Valbenazine	Valbenazine The metabolism of Desipramine can be decreased when combined with Valbenazine.
Safinamide	Safinamide The metabolism of Desipramine can be decreased when combined with Safinamide.
Naldemedine	Naldemedine Desipramine may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin	Midostaurin The metabolism of Desipramine can be decreased when combined with Midostaurin.
Neratinib	Neratinib The metabolism of Neratinib can be decreased when combined with Desipramine.
Enasidenib	Enasidenib The metabolism of Desipramine can be decreased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be decreased when combined with Desipramine.
Benznidazole	Benznidazole Desipramine may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Desipramine.
Delafloxacin	Delafloxacin The risk or severity of QTc prolongation can be increased when Desipramine is combined with Delafloxacin.
Abemaciclib	Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Desipramine.
Acalabrutinib	Acalabrutinib The metabolism of Desipramine can be decreased when combined with Acalabrutinib.
Letermovir	Letermovir The metabolism of Desipramine can be decreased when combined with Letermovir.
Semaglutide Injection	Semaglutide Injection Desipramine may decrease the hypoglycemic activities of Semaglutide.
Tetrabenazine	Tetrabenazine The metabolism of Desipramine can be decreased when combined with Tetrabenazine.
Ertugliflozin	Ertugliflozin Desipramine may decrease the hypoglycemic activities of Ertugliflozin.
Buprenorphine Injection	Buprenorphine Injection Desipramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide	Apalutamide Desipramine may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Baricitinib	Baricitinib The metabolism of Baricitinib can be decreased when combined with Desipramine.
Lofexidine	Lofexidine The therapeutic efficacy of Desipramine can be increased when used in combination with Lofexidine.
Plazomicin Injection	Plazomicin Injection Desipramine may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat	Eliglustat The metabolism of Eliglustat can be decreased when combined with Desipramine.
Encorafenib	Encorafenib The metabolism of Desipramine can be decreased when combined with Encorafenib.
Ivosidenib	Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Desipramine.
Elagolix	Elagolix The metabolism of Desipramine can be decreased when combined with Elagolix.
Tafenoquine	Tafenoquine The metabolism of Desipramine can be decreased when combined with Tafenoquine.
Cannabidiol	Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Desipramine.
Dacomitinib	Dacomitinib The metabolism of Desipramine can be decreased when combined with Dacomitinib.
Duvelisib	Duvelisib The metabolism of Duvelisib can be decreased when combined with Desipramine.
Stiripentol	Stiripentol The metabolism of Desipramine can be decreased when combined with Stiripentol.
Gilteritinib	Gilteritinib The therapeutic efficacy of Desipramine can be decreased when used in combination with Gilteritinib.
Glasdegib	Glasdegib The risk or severity of QTc prolongation can be increased when Desipramine is combined with Glasdegib.
Lorlatinib	Lorlatinib The metabolism of Desipramine can be increased when combined with Lorlatinib.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Desipramine can be decreased when combined with Paclitaxel.
Rifamycin	Rifamycin The metabolism of Desipramine can be decreased when combined with Rifamycin.
Prucalopride	Prucalopride The metabolism of Desipramine can be decreased when combined with Prucalopride.
Magnesium Citrate	Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Desipramine.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Desipramine can be increased when combined with Emapalumab.
Siponimod	Siponimod The metabolism of Siponimod can be decreased when combined with Desipramine.
Acyclovir Ophthalmic	Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Desipramine which could result in a higher serum level.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Desipramine.
Alpelisib	Alpelisib The metabolism of Desipramine can be decreased when combined with Alpelisib.
Brexanolone Injection	Brexanolone Injection Brexanolone may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Solriamfetol	Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Desipramine.
Triclabendazole	Triclabendazole The metabolism of Desipramine can be decreased when combined with Triclabendazole.
Entrectinib	Entrectinib The risk or severity of QTc prolongation can be increased when Desipramine is combined with Entrectinib.
Pexidartinib	Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Desipramine.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Desipramine.
Pitolisant	Pitolisant The therapeutic efficacy of Pitolisant can be decreased when used in combination with Desipramine.
Fedratinib	Fedratinib The metabolism of Desipramine can be decreased when combined with Fedratinib.
Lefamulin	Lefamulin Desipramine may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection	Phenytoin Injection The metabolism of Desipramine can be decreased when combined with Phenytoin.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Desipramine can be decreased when combined with Fosphenytoin.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Desipramine.
Voxelotor	Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Desipramine.
Lumateperone	Lumateperone Lumateperone may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Lasmiditan	Lasmiditan The risk or severity of serotonin syndrome can be increased when Desipramine is combined with Lasmiditan.
Tazemetostat	Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Desipramine.
Cenobamate	Cenobamate The serum concentration of Desipramine can be decreased when it is combined with Cenobamate.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Desipramine.
Selpercatinib	Selpercatinib The risk or severity of hypertension can be increased when Desipramine is combined with Selpercatinib.
Lemborexant	Lemborexant The serum concentration of Desipramine can be decreased when it is combined with Lemborexant.
Fenfluramine	Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Desipramine.
Fostemsavir	Fostemsavir The risk or severity of QTc prolongation can be increased when Desipramine is combined with Fostemsavir.
Octreotide	Octreotide The risk or severity of QTc prolongation can be increased when Octreotide is combined with Desipramine.
Naxitamab-gqgk Injection	Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Desipramine is combined with Naxitamab.
Relugolix	Relugolix The risk or severity of QTc prolongation can be increased when Desipramine is combined with Relugolix.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Desipramine.
Viloxazine	Viloxazine Viloxazine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Theophylline	Theophylline The metabolism of Theophylline can be decreased when combined with Desipramine.
Fenoprofen	Fenoprofen Fenoprofen may decrease the excretion rate of Desipramine which could result in a higher serum level.
Indomethacin	Indomethacin Indomethacin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Mefenamic Acid	Mefenamic Acid Mefenamic acid may decrease the excretion rate of Desipramine which could result in a higher serum level.
Naproxen	Naproxen Naproxen may decrease the excretion rate of Desipramine which could result in a higher serum level.
Tolmetin	Tolmetin Tolmetin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Sulindac	Sulindac Sulindac may decrease the excretion rate of Desipramine which could result in a higher serum level.
Trazodone	Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Desipramine.
Isotretinoin	Isotretinoin Isotretinoin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Sucralfate	Sucralfate Sucralfate may decrease the excretion rate of Desipramine which could result in a higher serum level.
Hydroxyurea	Hydroxyurea The metabolism of Desipramine can be decreased when combined with Hydroxyurea.
Floxuridine	Floxuridine Floxuridine may decrease the excretion rate of Desipramine which could result in a higher serum level.
Phenobarbital	Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Desipramine.
Metaxalone	Metaxalone Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Methotrexate Injection	Methotrexate Injection The metabolism of Desipramine can be decreased when combined with Methotrexate.
Levorphanol	Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Desipramine.
Primidone	Primidone The metabolism of Desipramine can be increased when combined with Primidone.
Methsuximide	Methsuximide Methsuximide may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Diethylpropion	Diethylpropion Diethylpropion may decrease the sedative and stimulatory activities of Desipramine.
Chlorpromazine	Chlorpromazine The metabolism of Desipramine can be decreased when combined with Chlorpromazine.
Diazepam	Diazepam Diazepam may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Oxazepam	Oxazepam Oxazepam may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Flurazepam	Flurazepam Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Clorazepate	Clorazepate Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Lorazepam	Lorazepam The metabolism of Lorazepam can be decreased when combined with Desipramine.
Phenoxybenzamine	Phenoxybenzamine The risk or severity of hypertension can be increased when Phenoxybenzamine is combined with Desipramine.
Carmustine	Carmustine Carmustine may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amantadine	Amantadine The serum concentration of Desipramine can be increased when it is combined with Amantadine.
Codeine	Codeine The metabolism of Desipramine can be decreased when combined with Codeine.
Meprobamate	Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Desipramine.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Desipramine.
Bromocriptine	Bromocriptine Bromocriptine may increase the vasopressor activities of Desipramine.
Metaproterenol	Metaproterenol The risk or severity of hypertension can be increased when Desipramine is combined with Orciprenaline.
Tranylcypromine	Tranylcypromine The metabolism of Desipramine can be decreased when combined with Tranylcypromine.
Phenelzine	Phenelzine The metabolism of Desipramine can be decreased when combined with Phenelzine.
Procarbazine	Procarbazine Procarbazine may increase the serotonergic activities of Desipramine.
Ergoloid Mesylates	Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Desipramine.
Tetracycline	Tetracycline Tetracycline may decrease the excretion rate of Desipramine which could result in a higher serum level.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Prochlorperazine	Prochlorperazine The metabolism of Desipramine can be decreased when combined with Prochlorperazine.
Thioridazine	Thioridazine The metabolism of Desipramine can be decreased when combined with Thioridazine.
Trifluoperazine	Trifluoperazine The serum concentration of Desipramine can be increased when it is combined with Trifluoperazine.
Bleomycin	Bleomycin Bleomycin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Sulfadiazine	Sulfadiazine Desipramine may decrease the hypoglycemic activities of Sulfadiazine.
Oxycodone	Oxycodone The metabolism of Desipramine can be decreased when combined with Oxycodone.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Desipramine.
Oxybutynin	Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Desipramine.
Benztropine	Benztropine The metabolism of Desipramine can be decreased when combined with Benzatropine.
Maprotiline	Maprotiline The metabolism of Desipramine can be decreased when combined with Maprotiline.
Ibuprofen	Ibuprofen Ibuprofen may decrease the excretion rate of Desipramine which could result in a higher serum level.
Trihexyphenidyl	Trihexyphenidyl Desipramine may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine	Orphenadrine Desipramine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine	Perphenazine The metabolism of Desipramine can be decreased when combined with Perphenazine.
Azathioprine	Azathioprine Azathioprine may decrease the excretion rate of Desipramine which could result in a higher serum level.
Fluphenazine	Fluphenazine The serum concentration of Desipramine can be increased when it is combined with Fluphenazine.
Phentermine	Phentermine Phentermine may decrease the sedative and stimulatory activities of Desipramine.
Methylphenidate	Methylphenidate The risk or severity of adverse effects can be increased when Methylphenidate is combined with Desipramine.
Amoxapine	Amoxapine The metabolism of Desipramine can be decreased when combined with Amoxapine.
Sulfasalazine	Sulfasalazine Sulfasalazine may decrease the excretion rate of Desipramine which could result in a higher serum level.
Hydrocortisone	Hydrocortisone The metabolism of Desipramine can be increased when combined with Hydrocortisone.
Doxorubicin	Doxorubicin The metabolism of Desipramine can be decreased when combined with Doxorubicin.
Cytarabine	Cytarabine The risk or severity of adverse effects can be increased when Desipramine is combined with Cytarabine.
Mechlorethamine	Mechlorethamine The therapeutic efficacy of Desipramine can be decreased when used in combination with Mechlorethamine.
Pyridostigmine	Pyridostigmine The therapeutic efficacy of Desipramine can be decreased when used in combination with Pyridostigmine.
Phenazopyridine	Phenazopyridine Phenazopyridine may decrease the excretion rate of Desipramine which could result in a higher serum level.
Carbamazepine	Carbamazepine The metabolism of Desipramine can be decreased when combined with Carbamazepine.
Molindone	Molindone The risk or severity of adverse effects can be increased when Desipramine is combined with Molindone.
Methyldopa	Methyldopa The risk or severity of hypertension can be increased when Desipramine is combined with Methyldopa.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Desipramine.
Prazosin	Prazosin The serum concentration of Prazosin can be increased when it is combined with Desipramine.
Hydralazine	Hydralazine Desipramine may decrease the antihypertensive activities of Hydralazine.
Cimetidine	Cimetidine The metabolism of Desipramine can be decreased when combined with Cimetidine.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Warfarin	Warfarin The serum concentration of Warfarin can be increased when it is combined with Desipramine.
Clonazepam	Clonazepam Clonazepam may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Loperamide	Loperamide The metabolism of Desipramine can be decreased when combined with Loperamide.
Promethazine	Promethazine The metabolism of Desipramine can be decreased when combined with Promethazine.
Meclofenamate	Meclofenamate Meclofenamic acid may decrease the excretion rate of Desipramine which could result in a higher serum level.
Nitrofurantoin	Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Digoxin	Digoxin Digoxin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Loxapine	Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Desipramine.
Chloroquine	Chloroquine The metabolism of Desipramine can be decreased when combined with Chloroquine.
Quinine	Quinine The metabolism of Desipramine can be decreased when combined with Quinine.
Ethosuximide	Ethosuximide Ethosuximide may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Triamterene	Triamterene Triamterene may decrease the excretion rate of Desipramine which could result in a higher serum level.
Lactulose	Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Desipramine.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Desipramine can be increased when combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide Desipramine may increase the excretion rate of Chlorothiazide which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone	Chlorthalidone Desipramine may increase the excretion rate of Chlorthalidone which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone	Metolazone Desipramine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide	Isosorbide Isosorbide may increase the excretion rate of Desipramine which could result in a lower serum level and potentially a reduction in efficacy.
Clindamycin Injection	Clindamycin Injection Desipramine may increase the neurotoxic activities of Clindamycin.
Secobarbital	Secobarbital Secobarbital may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Desipramine.
Imipramine	Imipramine The metabolism of Desipramine can be decreased when combined with Imipramine.
Probenecid	Probenecid Probenecid may decrease the excretion rate of Desipramine which could result in a higher serum level.
Quinidine	Quinidine The metabolism of Desipramine can be decreased when combined with Quinidine.
Procainamide	Procainamide The metabolism of Desipramine can be decreased when combined with Procainamide.
Isoniazid	Isoniazid The risk or severity of serotonin syndrome can be increased when Isoniazid is combined with Desipramine.
Pyrazinamide	Pyrazinamide Pyrazinamide may decrease the excretion rate of Desipramine which could result in a higher serum level.
Disopyramide	Disopyramide Desipramine may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
Valproic Acid	Valproic Acid Valproic acid may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Tamoxifen	Tamoxifen The metabolism of Desipramine can be decreased when combined with Tamoxifen.
Butabarbital	Butabarbital Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Levothyroxine	Levothyroxine The risk or severity of Cardiac Arrhythmia and CNS stimulation can be increased when Levothyroxine is combined with Desipramine.
Liothyronine	Liothyronine The risk or severity of Cardiac Arrhythmia can be increased when Liothyronine is combined with Desipramine.
Methimazole	Methimazole The risk or severity of Cardiac Arrhythmia can be increased when Methimazole is combined with Desipramine.
Propylthiouracil	Propylthiouracil The risk or severity of Cardiac Arrhythmia can be increased when Propylthiouracil is combined with Desipramine.
Chlorpropamide	Chlorpropamide Desipramine may decrease the hypoglycemic activities of Chlorpropamide.
Glucagon Injection	Glucagon Injection Desipramine may increase the gastrointestinal motility reducing activities of Glucagon.
Tolbutamide	Tolbutamide Desipramine may decrease the hypoglycemic activities of Tolbutamide.
Tolazamide	Tolazamide Desipramine may decrease the hypoglycemic activities of Tolazamide.
Dextromethorphan	Dextromethorphan The metabolism of Desipramine can be decreased when combined with Dextromethorphan.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of CNS depression can be increased when Desipramine is combined with Cyclobenzaprine.
Niacin	Niacin The metabolism of Desipramine can be decreased when combined with Niacin.
Baclofen	Baclofen The risk or severity of CNS depression and hypotonia can be increased when Baclofen is combined with Desipramine.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Cyproheptadine	Cyproheptadine Cyproheptadine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Clemastine	Clemastine The metabolism of Desipramine can be decreased when combined with Clemastine.
Chlorpheniramine	Chlorpheniramine The metabolism of Desipramine can be decreased when combined with Chlorpheniramine.
Brompheniramine	Brompheniramine Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Meclizine	Meclizine The metabolism of Desipramine can be decreased when combined with Meclizine.
Ethambutol	Ethambutol Ethambutol may decrease the excretion rate of Desipramine which could result in a higher serum level.
Methyclothiazide	Methyclothiazide Desipramine may increase the excretion rate of Methyclothiazide which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide	Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Desipramine is combined with Hydrochlorothiazide.
Dantrolene	Dantrolene Dantrolene may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Chlorzoxazone	Chlorzoxazone The metabolism of Desipramine can be decreased when combined with Chlorzoxazone.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Desipramine.
Methocarbamol	Methocarbamol Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Pyridoxine	Pyridoxine Pyridoxine may decrease the excretion rate of Desipramine which could result in a higher serum level.
Folic Acid	Folic Acid Folic acid may decrease the excretion rate of Desipramine which could result in a higher serum level.
Disulfiram	Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Desipramine.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Desipramine.
Minoxidil	Minoxidil Desipramine may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine	Pseudoephedrine Pseudoephedrine may decrease the sedative and stimulatory activities of Desipramine.
Nortriptyline	Nortriptyline The metabolism of Desipramine can be decreased when combined with Nortriptyline.
Spironolactone	Spironolactone Spironolactone may increase the excretion rate of Desipramine which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection	Amphotericin B Injection Amphotericin B may decrease the excretion rate of Desipramine which could result in a higher serum level.
Phytonadione	Phytonadione Phylloquinone may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amikacin Injection	Amikacin Injection Amikacin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Nadolol	Nadolol The metabolism of Desipramine can be decreased when combined with Nadolol.
Butorphanol Injection	Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Desipramine.
Nalbuphine Injection	Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Desipramine.
Allopurinol	Allopurinol Allopurinol may decrease the excretion rate of Desipramine which could result in a higher serum level.
Oxytocin Injection	Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Desipramine.
Trimethobenzamide	Trimethobenzamide Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Flavoxate	Flavoxate Desipramine may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Papaverine	Papaverine The risk or severity of QTc prolongation can be increased when Desipramine is combined with Papaverine.
Fluorouracil Injection	Fluorouracil Injection The risk or severity of QTc prolongation can be increased when Desipramine is combined with Fluorouracil.
Colchicine	Colchicine The metabolism of Colchicine can be decreased when combined with Desipramine.
Cefaclor	Cefaclor Cefaclor may decrease the excretion rate of Desipramine which could result in a higher serum level.
Cefadroxil	Cefadroxil Cefadroxil may decrease the excretion rate of Desipramine which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection Cefazolin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Cephalexin	Cephalexin The metabolism of Cephalexin can be decreased when combined with Desipramine.
Cefoxitin Injection	Cefoxitin Injection Cefoxitin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Dacarbazine	Dacarbazine Dacarbazine may decrease the excretion rate of Desipramine which could result in a higher serum level.
Acetazolamide	Acetazolamide Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Cefotaxime Injection	Cefotaxime Injection Cefotaxime may decrease the excretion rate of Desipramine which could result in a higher serum level.
Calcitonin Salmon Injection	Calcitonin Salmon Injection The risk or severity of Cardiac Arrhythmia can be increased when Salmon calcitonin is combined with Desipramine.
Ketoconazole	Ketoconazole The metabolism of Desipramine can be decreased when combined with Ketoconazole.
Pyrantel	Pyrantel Pyrantel may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Thiotepa Injection	Thiotepa Injection The metabolism of Desipramine can be decreased when combined with Thiotepa.
Vincristine Injection	Vincristine Injection The metabolism of Desipramine can be decreased when combined with Vincristine.
Captopril	Captopril Desipramine may decrease the antihypertensive activities of Captopril.
Isoxsuprine	Isoxsuprine The risk or severity of hypertension can be increased when Desipramine is combined with Isoxsuprine.
Vinblastine	Vinblastine The metabolism of Desipramine can be decreased when combined with Vinblastine.
Ethacrynic Acid	Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Desipramine which could result in a higher serum level.
Colistimethate Injection	Colistimethate Injection Colistimethate may decrease the excretion rate of Desipramine which could result in a higher serum level.
Metoprolol	Metoprolol The metabolism of Desipramine can be decreased when combined with Metoprolol.
Hydroxyzine	Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Desipramine.
Thiothixene	Thiothixene The risk or severity of adverse effects can be increased when Desipramine is combined with Thiothixene.
Aspirin	Aspirin Acetylsalicylic acid may decrease the excretion rate of Desipramine which could result in a higher serum level.
Salsalate	Salsalate Desipramine may decrease the excretion rate of Salsalate which could result in a higher serum level.
Alprazolam	Alprazolam The metabolism of Alprazolam can be decreased when combined with Desipramine.
Temazepam	Temazepam Temazepam may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Triazolam	Triazolam Triazolam may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Dicyclomine	Dicyclomine Desipramine may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine	Hyoscyamine Desipramine may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline	Propantheline Desipramine may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim	Trimethoprim Trimethoprim may decrease the excretion rate of Desipramine which could result in a higher serum level.
Diltiazem	Diltiazem The metabolism of Desipramine can be decreased when combined with Diltiazem.
Nifedipine	Nifedipine The metabolism of Desipramine can be decreased when combined with Nifedipine.
Timolol	Timolol The metabolism of Timolol can be decreased when combined with Desipramine.
Verapamil	Verapamil The metabolism of Desipramine can be decreased when combined with Verapamil.
Atenolol	Atenolol The metabolism of Desipramine can be decreased when combined with Atenolol.
Pindolol	Pindolol The metabolism of Desipramine can be decreased when combined with Pindolol.
Cisplatin Injection	Cisplatin Injection The serum concentration of Desipramine can be increased when it is combined with Cisplatin.
Diflunisal	Diflunisal Diflunisal may decrease the excretion rate of Desipramine which could result in a higher serum level.
Piroxicam	Piroxicam Piroxicam may decrease the excretion rate of Desipramine which could result in a higher serum level.
Bumetanide	Bumetanide Bumetanide may decrease the excretion rate of Desipramine which could result in a higher serum level.
Etoposide	Etoposide The metabolism of Desipramine can be decreased when combined with Etoposide.
Glyburide	Glyburide Desipramine may decrease the hypoglycemic activities of Glyburide.
Glipizide	Glipizide Desipramine may decrease the hypoglycemic activities of Glipizide.
Indapamide	Indapamide The risk or severity of QTc prolongation can be increased when Desipramine is combined with Indapamide.
Amoxicillin	Amoxicillin Amoxicillin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Oxacillin Injection	Oxacillin Injection Oxacillin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Pentoxifylline	Pentoxifylline Pentoxifylline may decrease the excretion rate of Desipramine which could result in a higher serum level.
Pentamidine Injection	Pentamidine Injection The metabolism of Desipramine can be decreased when combined with Pentamidine.
Ceftriaxone Injection	Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Desipramine which could result in a higher serum level.
Labetalol	Labetalol The metabolism of Desipramine can be decreased when combined with Labetalol.
Auranofin	Auranofin Auranofin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Leuprolide Injection	Leuprolide Injection The risk or severity of QTc prolongation can be increased when Desipramine is combined with Leuprolide.
Gemfibrozil	Gemfibrozil Desipramine may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Guanabenz	Guanabenz The therapeutic efficacy of Guanabenz can be decreased when used in combination with Desipramine.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Desipramine which could result in a higher serum level.
Ceftazidime Injection	Ceftazidime Injection Ceftazidime may decrease the excretion rate of Desipramine which could result in a higher serum level.
Ketoprofen	Ketoprofen Ketoprofen may decrease the excretion rate of Desipramine which could result in a higher serum level.
Cefotetan Injection	Cefotetan Injection Cefotetan may decrease the excretion rate of Desipramine which could result in a higher serum level.
Pimozide	Pimozide The metabolism of Desipramine can be decreased when combined with Pimozide.
Enalapril	Enalapril Desipramine may decrease the antihypertensive activities of Enalapril.
Flurbiprofen	Flurbiprofen Flurbiprofen may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amiodarone	Amiodarone The metabolism of Desipramine can be decreased when combined with Amiodarone.
Aztreonam Injection	Aztreonam Injection Aztreonam may decrease the excretion rate of Desipramine which could result in a higher serum level.
Buspirone	Buspirone The metabolism of Buspirone can be decreased when combined with Desipramine.
Lovastatin	Lovastatin The metabolism of Lovastatin can be decreased when combined with Desipramine.
Ciprofloxacin	Ciprofloxacin The risk or severity of QTc prolongation can be increased when Desipramine is combined with Ciprofloxacin.
Mesalamine	Mesalamine Mesalazine may decrease the excretion rate of Desipramine which could result in a higher serum level.
Diclofenac	Diclofenac Diclofenac may decrease the excretion rate of Desipramine which could result in a higher serum level.
Fluoxetine	Fluoxetine The serum concentration of Desipramine can be increased when it is combined with Fluoxetine.
Nimodipine	Nimodipine The risk or severity of QTc prolongation can be increased when Desipramine is combined with Nimodipine.
Clozapine	Clozapine The metabolism of Desipramine can be decreased when combined with Clozapine.
Estazolam	Estazolam Estazolam may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Idarubicin	Idarubicin The metabolism of Desipramine can be decreased when combined with Idarubicin.
Ofloxacin	Ofloxacin The risk or severity of QTc prolongation can be increased when Desipramine is combined with Ofloxacin.
Didanosine	Didanosine Didanosine may decrease the excretion rate of Desipramine which could result in a higher serum level.
Pentostatin Injection	Pentostatin Injection Pentostatin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Clarithromycin	Clarithromycin The risk or severity of QTc prolongation can be increased when Desipramine is combined with Clarithromycin.
Benazepril	Benazepril Desipramine may decrease the antihypertensive activities of Benazepril.
Etodolac	Etodolac Etodolac may decrease the excretion rate of Desipramine which could result in a higher serum level.
Felodipine	Felodipine The metabolism of Felodipine can be decreased when combined with Desipramine.
Fosinopril	Fosinopril Desipramine may decrease the antihypertensive activities of Fosinopril.
Nabumetone	Nabumetone Nabumetone may decrease the excretion rate of Desipramine which could result in a higher serum level.
Quinapril	Quinapril Desipramine may decrease the antihypertensive activities of Quinapril.
Ramipril	Ramipril Desipramine may decrease the antihypertensive activities of Ramipril.
Simvastatin	Simvastatin The metabolism of Simvastatin can be decreased when combined with Desipramine.
Amlodipine	Amlodipine Desipramine may decrease the antihypertensive activities of Amlodipine.
Teniposide Injection	Teniposide Injection The metabolism of Desipramine can be decreased when combined with Teniposide.
Itraconazole	Itraconazole The metabolism of Itraconazole can be decreased when combined with Desipramine.
Lisinopril	Lisinopril Desipramine may decrease the antihypertensive activities of Lisinopril.
Oxaprozin	Oxaprozin Oxaprozin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Rifabutin	Rifabutin The metabolism of Desipramine can be increased when combined with Rifabutin.
Sotalol	Sotalol The metabolism of Desipramine can be decreased when combined with Sotalol.
Bisoprolol	Bisoprolol Desipramine may decrease the antihypertensive activities of Bisoprolol.
Zolpidem	Zolpidem Desipramine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin	Doxazosin The metabolism of Desipramine can be decreased when combined with Doxazosin.
Terazosin	Terazosin Desipramine may decrease the antihypertensive activities of Terazosin.
Isradipine	Isradipine The risk or severity of QTc prolongation can be increased when Desipramine is combined with Isradipine.
Omeprazole	Omeprazole The metabolism of Desipramine can be decreased when combined with Omeprazole.
Cisapride	Cisapride The metabolism of Desipramine can be decreased when combined with Cisapride.
Gabapentin	Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Desipramine.
Fluvastatin	Fluvastatin The metabolism of Desipramine can be decreased when combined with Fluvastatin.
Venlafaxine	Venlafaxine The serum concentration of the active metabolites of Desipramine can be increased when Desipramine is used in combination with Venlafaxine.
Nizatidine	Nizatidine The therapeutic efficacy of Desipramine can be decreased when used in combination with Nizatidine.
Stavudine	Stavudine Stavudine may increase the neurotoxic activities of Desipramine.
Famciclovir	Famciclovir The metabolism of Famciclovir can be decreased when combined with Desipramine.
Fluvoxamine	Fluvoxamine The metabolism of Desipramine can be decreased when combined with Fluvoxamine.
Nefazodone	Nefazodone The metabolism of Desipramine can be decreased when combined with Nefazodone.
Lamotrigine	Lamotrigine Lamotrigine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Losartan	Losartan The risk or severity of QTc prolongation can be increased when Desipramine is combined with Losartan.
Valacyclovir	Valacyclovir Valaciclovir may decrease the excretion rate of Desipramine which could result in a higher serum level.
Tramadol	Tramadol The risk or severity of serotonin syndrome can be increased when Desipramine is combined with Tramadol.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Desipramine can be decreased when combined with Vinorelbine.
Carboplatin Injection	Carboplatin Injection Carboplatin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Moexipril	Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Desipramine.
Lansoprazole	Lansoprazole The metabolism of Desipramine can be decreased when combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Desipramine.
Nicardipine	Nicardipine The metabolism of Desipramine can be decreased when combined with Nicardipine.
Bupropion	Bupropion The risk or severity of seizure can be increased when Desipramine is combined with Bupropion.
Ticlopidine	Ticlopidine The metabolism of Desipramine can be decreased when combined with Ticlopidine.
Saquinavir	Saquinavir The metabolism of Saquinavir can be decreased when combined with Desipramine.
Metformin	Metformin Desipramine may decrease the hypoglycemic activities of Metformin.
Nisoldipine	Nisoldipine Desipramine may decrease the antihypertensive activities of Nisoldipine.
Lamivudine	Lamivudine The serum concentration of Lamivudine can be increased when it is combined with Desipramine.
Riluzole	Riluzole Riluzole may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Acarbose	Acarbose Desipramine may decrease the hypoglycemic activities of Acarbose.
Glimepiride	Glimepiride Desipramine may decrease the hypoglycemic activities of Glimepiride.
Gemcitabine Injection	Gemcitabine Injection Gemcitabine may decrease the excretion rate of Desipramine which could result in a higher serum level.
Ritonavir	Ritonavir The metabolism of Desipramine can be decreased when combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Desipramine can be decreased when combined with Docetaxel.
Cidofovir Injection	Cidofovir Injection Cidofovir may decrease the excretion rate of Desipramine which could result in a higher serum level.
Meropenem Injection	Meropenem Injection Meropenem may decrease the excretion rate of Desipramine which could result in a higher serum level.
Clomipramine	Clomipramine The metabolism of Clomipramine can be decreased when combined with Desipramine.
Zafirlukast	Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Desipramine.
Fosfomycin	Fosfomycin Fosfomycin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Mirtazapine	Mirtazapine Desipramine may increase the serotonergic activities of Mirtazapine.
Trandolapril	Trandolapril Desipramine may decrease the antihypertensive activities of Trandolapril.
Topiramate	Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Desipramine is combined with Topiramate.
Valsartan	Valsartan Desipramine may decrease the antihypertensive activities of Valsartan.
Insulin Lispro Injection	Insulin Lispro Injection Desipramine may decrease the hypoglycemic activities of Insulin lispro.
Pramipexole	Pramipexole Desipramine may increase the sedative activities of Pramipexole.
Donepezil	Donepezil The therapeutic efficacy of Desipramine can be decreased when used in combination with Donepezil.
Nelfinavir	Nelfinavir The metabolism of Desipramine can be decreased when combined with Nelfinavir.
Azithromycin	Azithromycin The risk or severity of QTc prolongation can be increased when Desipramine is combined with Azithromycin.
Loratadine	Loratadine Desipramine may increase the anticholinergic activities of Loratadine.
Carvedilol	Carvedilol The metabolism of Desipramine can be decreased when combined with Carvedilol.
Nilutamide	Nilutamide Nilutamide may decrease the excretion rate of Desipramine which could result in a higher serum level.
Flutamide	Flutamide Flutamide may decrease the excretion rate of Desipramine which could result in a higher serum level.
Selegiline	Selegiline The metabolism of Desipramine can be decreased when combined with Selegiline.
Bicalutamide	Bicalutamide The metabolism of Desipramine can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The metabolism of Desipramine can be decreased when combined with Sertraline.
Propafenone	Propafenone The metabolism of Desipramine can be decreased when combined with Propafenone.
Raloxifene	Raloxifene The metabolism of Desipramine can be decreased when combined with Raloxifene.
Irbesartan	Irbesartan Desipramine may decrease the antihypertensive activities of Irbesartan.
Tamsulosin	Tamsulosin The metabolism of Desipramine can be decreased when combined with Tamsulosin.
Ropinirole	Ropinirole Desipramine may increase the sedative activities of Ropinirole.
Finasteride	Finasteride The risk or severity of hypertension can be increased when Desipramine is combined with Finasteride.
Quetiapine	Quetiapine The metabolism of Quetiapine can be decreased when combined with Desipramine.
Cefepime Injection	Cefepime Injection Cefepime may decrease the excretion rate of Desipramine which could result in a higher serum level.
Cefprozil	Cefprozil Cefprozil may decrease the excretion rate of Desipramine which could result in a higher serum level.
Cefpodoxime	Cefpodoxime Cefpodoxime may decrease the excretion rate of Desipramine which could result in a higher serum level.
Cetirizine	Cetirizine Cetirizine may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Paroxetine	Paroxetine The metabolism of Desipramine can be decreased when combined with Paroxetine.
Tolcapone	Tolcapone Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Citalopram	Citalopram The metabolism of Citalopram can be decreased when combined with Desipramine.
Capecitabine	Capecitabine Capecitabine may decrease the excretion rate of Desipramine which could result in a higher serum level.
Efavirenz	Efavirenz Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Abacavir	Abacavir Abacavir may decrease the excretion rate of Desipramine which could result in a higher serum level.
Sildenafil	Sildenafil The metabolism of Sildenafil can be decreased when combined with Desipramine.
Pioglitazone	Pioglitazone Desipramine may decrease the hypoglycemic activities of Pioglitazone.
Celecoxib	Celecoxib The metabolism of Desipramine can be decreased when combined with Celecoxib.
Rosiglitazone	Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Desipramine.
Tolterodine	Tolterodine The metabolism of Desipramine can be decreased when combined with Tolterodine.
Thalidomide	Thalidomide Desipramine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir	Oseltamivir Oseltamivir may decrease the excretion rate of Desipramine which could result in a higher serum level.
Balsalazide	Balsalazide Balsalazide may decrease the excretion rate of Desipramine which could result in a higher serum level.
Nateglinide	Nateglinide The metabolism of Desipramine can be decreased when combined with Nateglinide.
Galantamine	Galantamine The metabolism of Desipramine can be decreased when combined with Galantamine.
Levetiracetam	Levetiracetam Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Rabeprazole	Rabeprazole The metabolism of Desipramine can be decreased when combined with Rabeprazole.
Terbinafine	Terbinafine The metabolism of Desipramine can be decreased when combined with Terbinafine.