Desipramine
114 interactions 6 explained in plain English
Also sold as:
Norpramin
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Metoclopramide Injection
Linezolid Injection
Metoclopramide Nasal Spray
Flurbiprofen Ophthalmic
Palonosetron Injection
Relugolix
Contraindicated
Desipramine Linezolid Injection Zyvox An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Desipramine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Desipramine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome DetailsMajor
Desipramine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Desipramine Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Desipramine Sertraline Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Desipramine Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular system effects Details Desipramine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Desipramine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Desipramine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Desipramine Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Desipramine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Desipramine Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Desipramine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Desipramine Aspirin Acuprin® An increased risk of bleeding Details Desipramine Aspirin Rectal Aspirin An increased risk of bleeding Details Desipramine Azithromycin AzaSite An increased risk of QT interval prolongation Details Desipramine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Desipramine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Desipramine Anagrelide Agrylin Increased risk of QT interval prolongation Details Desipramine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Desipramine Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Desipramine Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Desipramine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Desipramine Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Desipramine Clonidine Transdermal Patch Catapres Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Desipramine Dacomitinib Vizimpro Increased exposure of the CYP2D6 substrate Details Desipramine Dasatinib Phyrago An increased risk of QT interval prolongation Details Desipramine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Desipramine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Desipramine Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Desipramine Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Desipramine Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Desipramine Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Desipramine Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Desipramine Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Desipramine Dolasetron Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Desipramine Dolasetron Injection Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Desipramine Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Desipramine Encorafenib Braftovi Increased risk of QT interval prolongation DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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