Drug & supplement interaction

Dandelion + Desipramine

Desipramine brand names: Norpramin, Desipramine, Pertofrane.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Dandelion has a moderate interaction with Desipramine. Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Dandelion and Desipramine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES

Why this applies to Desipramine

Desipramine falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Dandelion interacts with.

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the short version: your body uses a liver enzyme called CYP1A2 to help clear desipramine. In lab studies, dandelion appears to slow that enzyme down. If that happened in real life, desipramine could build up a bit more than expected, which might mean stronger effects and more of its usual side effects, things like dry mouth, constipation, drowsiness, dizziness when you stand, or a faster heartbeat.

The big caveat is that this is only test-tube evidence and hasn't actually been seen in people, so it may not matter much in practice. Food amounts of dandelion (like in salads or tea) are very unlikely to be an issue. If you're thinking about a concentrated dandelion supplement, just run it by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Dandelion Also Interacts With Other Medications

Dandelion has 456 moderate known drug interactions in our database — the Desipramine one above is one of them. If you take anything else, check it against the full list below.

Moderate 456 No known interaction 2,374 (incl. Desipramine)
Taking anything else?

Check Another of Your Medications Against Dandelion

Covers the 2,830 medications we’ve checked against Dandelion. Pick one to open its full report.

From our Q&A

Questions About Dandelion or Desipramine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Dandelion or Desipramine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Desipramine

This page covers Dandelion only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Desipramine page lists 253 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), Arsenic (major) and Beer (major).

By severity: 16 major · 198 moderate · 39 minor.

Open the Desipramine interaction page

One more smart check

Taking Dandelion as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,328 real supplement products containing Dandelion, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dandelion. Your product may carry other ingredients that interact with Desipramine too, on top of Dandelion — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dandelion and Desipramine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dandelion
Top 5%

#55 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Desipramine
Top half

#1,109 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Dandelion

What is Dandelion?

Dandelion
  • Water retention (diuretic)
  • Digestive upset
  • Liver and gallbladder support
  • Mild appetite stimulant
  • Skin conditions

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits are not well proven. It is generally considered safe as a food, but talk to your pharmacist or doctor before using concentrated supplements, especially if you have allergies or take other medicines.

Read the full Dandelion monograph & all interactions
Medication

About Desipramine

What Is Desipramine Used For?

Brand names: Norpramin, Desipramine, Pertofrane

Desipramine hydrochloride tablets — sold under the brand names Norpramin, Desipramine HCL, and Desipramine Hydrochloride — are FDA-approved for the treatment of depression in adults. Norpramin tablets and the generic formulations share this same approved indication.

Desipramine tablets are not approved for use in children. Adolescents and elderly patients may be prescribed it in certain circumstances, but at lower doses and under close supervision.

See full Desipramine drug information
Keep checking

Other Drugs & Dandelion

Browse every other medication we’ve checked against Dandelion — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
456Moderate
0Minor
2,373No known interaction
456 Moderate 2,373 No interaction
Moderate

456 interactions

Showing 60 of 456 moderate interactions — see all 456 on the Dandelion page.

No interaction 2,373 drugs checked — show the list

We also checked Dandelion against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,373 medications checked with no known interaction — see the full Dandelion list.

See the full Dandelion interactions page
See every supplement checked against Desipramine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Dandelion monograph › Uses, safety, and every drug interaction in one place Desipramine supplement interactions › Every supplement checked against Desipramine, ranked by severity Desipramine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Dandelion and Desipramine Together: Common Questions

Can you take Dandelion with Desipramine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Dandelion and Desipramine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Desipramine and Dandelion?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.