Protriptyline

Generic name: Pronounced as (proe trip' ti leen)
Brand names
  • Vivactil®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 09/15/2018

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as protriptyline during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take protriptyline, but in some cases, a doctor may decide that protriptyline is the best medication to treat a child's condition.

You should know that your mental health may change in unexpected ways when you take protriptyline or other antidepressants even if you are an adult over age 24. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor when you are unable to seek treatment on your own.

Your healthcare provider will want to see you often while you are taking protriptyline, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.

The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with protriptyline. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/UCM096273.

No matter what your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

Protriptyline is used to treat depression. Protriptyline is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that help maintain mental balance.

Protriptyline comes as a tablet to take by mouth. It is usually taken three or four times a day. Take protriptyline at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take protriptyline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of protriptyline and gradually increase your dose. Your doctor may decrease your dose after your condition is controlled.

Protriptyline controls depression but does not cure it. Continue to take protriptyline even if you feel well. Do not stop taking protriptyline without talking to your doctor. If you suddenly stop taking protriptyline, you may experience withdrawal symptoms such as nausea, headache, and lack of energy.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking protriptyline,

  • tell your doctor and pharmacist if you are allergic to protriptyline or any other medications.

  • tell your doctor if you are taking cisapride (Propulsid) (not available in the U.S.) or monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan); phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have taken an MAO inhibitor during the past 14 days. Your doctor will probably tell you that you should not take protriptyline.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); antihistamines; bupropion (Wellbutrin); celecoxib (Celebrex); cimetidine (Tagamet); doxorubicin (Adriamycin); guanethidine (Ismelin); ipratropium (Atrovent); medications for anxiety, asthma, colds, diabetes, irritable bowel disease, mental illness, motion sickness, Parkinson's disease, seizures, ulcers, or urinary problems; medications for irregular heartbeat such as flecainide (Tambocor), moricizine (Ethmozine), and propafenone (Rythmol); methadone (Dolophine); metoclopramide (Reglan); other antidepressants; quinidine; ranitidine (Zantac); reserpine (Serpasil); ritonavir (Norvir); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); sedatives; sleeping pills; terbinafine (Lamisil); thyroid medications; tramadol (Ultram); and tranquilizers. Tell your doctor or pharmacist if you have stopped taking fluoxetine (Prozac, Sarafem) in the past 5 weeks. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have recently had a heart attack. Your doctor will probably tell you not to take protriptyline.

  • tell your doctor if you drink large amounts of alcohol; if you are undergoing electroshock therapy (procedure in which small electric shocks are administered to the brain to treat certain mental illnesses); or if you have or have ever had an enlarged prostate (a male reproductive organ), difficulty urinating, mental illness, seizures, hyperthyroidism (an overactive thyroid gland), or diabetes.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking protriptyline, call your doctor.

  • talk to your doctor about the risks and benefits of taking protriptyline if you are 65 years of age or older. Older adults should not usually take protriptyline because it is not as safe or effective as other medications that can be used to treat the same condition.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking protriptyline.

  • you should know that protriptyline may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

  • remember that alcohol can add to the drowsiness caused by this medication.

  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Protriptyline may make your skin sensitive to sunlight.

  • you should know that protriptyline may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking protriptyline. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

  • you should know that protriptyline may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Protriptyline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • diarrhea

    • loss of appetite

    • weight changes

    • unusual taste in the mouth

    • stomach pain or cramps

    • heartburn

    • dry mouth

    • constipation

    • drowsiness

    • dizziness

    • nightmares

    • headaches

    • frequent urination, especially at night

    • difficulty urinating

    • wide pupils

    • changes in sex drive or ability

    • breast enlargement in men and women

    • unsteadiness

    • ringing in ears

    • hair loss

    • flushing

    • sweating

    • black tongue

  • Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately:

    • slow or difficult speech

    • weakness or numbness of an arm or a leg

    • crushing chest pain

    • rapid, pounding, or irregular heartbeat

    • rash or hives

    • itching

    • swelling of the face or tongue

    • yellowing of the skin or eyes

    • jaw, neck, and back muscle spasms

    • uncontrollable shaking of a part of the body

    • fainting

    • difficulty walking

    • unusual bleeding or bruising

    • seizures

    • confusion

    • hallucination (seeing things or hearing voices that do not exist)

    • believing things that are not true

    • fever

    • pain, burning, or tingling in the hands or feet

  • Protriptyline may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • irregular heartbeat

  • loss of consciousness

  • fainting

  • seizures

  • confusion

  • problems concentrating

  • hallucination (seeing things or hearing voices that do not exist)

  • agitation

  • drowsiness

  • stiff muscles

  • vomiting

  • fever

  • cold body temperature

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Moxifloxacin.
Repaglinide Repaglinide Protriptyline may decrease the hypoglycemic activities of Repaglinide.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection Protriptyline may decrease the hypoglycemic activities of Insulin glargine.
Delavirdine Delavirdine The metabolism of Protriptyline can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Protriptyline can be decreased when combined with Nevirapine.
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Protriptyline is combined with Dolasetron.
Anagrelide Anagrelide The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Anagrelide.
Candesartan Candesartan Protriptyline may decrease the antihypertensive activities of Candesartan.
Cilostazol Cilostazol The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Cilostazol.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Protriptyline is combined with Diphenoxylate.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The serum concentration of Protriptyline can be increased when it is combined with Conjugated estrogens.
Guanfacine Guanfacine The therapeutic efficacy of Guanfacine can be decreased when used in combination with Protriptyline.
Methylergonovine Methylergonovine The risk or severity of hypertension can be increased when Protriptyline is combined with Methylergometrine.
Miglitol Miglitol Protriptyline may decrease the hypoglycemic activities of Miglitol.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Protriptyline is combined with Naratriptan.
Olsalazine Olsalazine The risk or severity of hypertension can be increased when Protriptyline is combined with Olsalazine.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Protriptyline.
Penbutolol Penbutolol The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Acebutolol.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Protriptyline is combined with Pentazocine.
Ranitidine Ranitidine The metabolism of Protriptyline can be decreased when combined with Ranitidine.
Reserpine Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Protriptyline.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Protriptyline is combined with Rizatriptan.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Protriptyline is combined with Sumatriptan.
Tacrolimus Tacrolimus The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Tacrolimus.
Tizanidine Tizanidine The therapeutic efficacy of Tizanidine can be decreased when used in combination with Protriptyline.
Zolmitriptan Zolmitriptan The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Protriptyline.
Famotidine Injection Famotidine Injection The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Famotidine.
Fluconazole Injection Fluconazole Injection The risk or severity of QTc prolongation can be increased when Fluconazole is combined with Protriptyline.
Foscarnet Injection Foscarnet Injection The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Foscarnet.
Hydromorphone Injection Hydromorphone Injection The risk or severity of serotonin syndrome can be increased when Hydromorphone is combined with Protriptyline.
Levofloxacin Injection Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Levofloxacin.
Meperidine Injection Meperidine Injection The risk or severity of adverse effects can be increased when Protriptyline is combined with Meperidine.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Protriptyline.
Metronidazole Injection Metronidazole Injection The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Protriptyline.
Altretamine Altretamine The therapeutic efficacy of Protriptyline can be increased when used in combination with Amphetamine.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Protriptyline.
Ondansetron Ondansetron The risk or severity of adverse effects can be increased when Protriptyline is combined with Ondansetron.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Protriptyline is combined with Granisetron.
Torsemide Torsemide Protriptyline may decrease the antihypertensive activities of Torasemide.
Olanzapine Olanzapine Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.
Alosetron Alosetron The risk or severity of adverse effects can be increased when Protriptyline is combined with Alosetron.
Dofetilide Dofetilide The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Dofetilide.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Protriptyline is combined with Entacapone.
Eprosartan Eprosartan Protriptyline may decrease the antihypertensive activities of Eprosartan.
Hydroxychloroquine Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Hydroxychloroquine.
Meloxicam Meloxicam The risk or severity of hypertension can be increased when Protriptyline is combined with Meloxicam.
Oxcarbazepine Oxcarbazepine The risk or severity of adverse effects can be increased when Protriptyline is combined with Oxcarbazepine.
Telmisartan Telmisartan Protriptyline may decrease the antihypertensive activities of Telmisartan.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Protriptyline is combined with Zaleplon.
Anakinra Anakinra The metabolism of Protriptyline can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Desloratadine.
Linezolid Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Protriptyline.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Protriptyline.
Etanercept Injection Etanercept Injection The metabolism of Protriptyline can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Perindopril Perindopril Protriptyline may decrease the antihypertensive activities of Perindopril.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of hypertension can be increased when Protriptyline is combined with Choline magnesium trisalicylate.
Dutasteride Dutasteride The risk or severity of hypertension can be increased when Protriptyline is combined with Dutasteride.
Epinephrine Injection Epinephrine Injection Protriptyline may increase the vasopressor activities of Epinephrine.
Eplerenone Eplerenone Protriptyline may decrease the antihypertensive activities of Eplerenone.
Escitalopram Escitalopram The risk or severity of serotonin syndrome can be increased when Protriptyline is combined with Escitalopram.
Olmesartan Olmesartan Protriptyline may decrease the antihypertensive activities of Olmesartan.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Protriptyline is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Protriptyline can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Protriptyline.
Dexmethylphenidate Dexmethylphenidate The serum concentration of Protriptyline can be increased when it is combined with Dexmethylphenidate.
Atazanavir Atazanavir The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Atazanavir.
Almotriptan Almotriptan The risk or severity of adverse effects can be increased when Protriptyline is combined with Almotriptan.
Eletriptan Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Protriptyline.
Mefloquine Mefloquine The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Mefloquine.
Vardenafil Vardenafil The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Vardenafil.
Alfuzosin Alfuzosin The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Alfuzosin.
Tegaserod Tegaserod The metabolism of Protriptyline can be decreased when combined with Tegaserod.
Tadalafil Tadalafil Protriptyline may decrease the antihypertensive activities of Tadalafil.
Frovatriptan Frovatriptan The risk or severity of adverse effects can be increased when Protriptyline is combined with Frovatriptan.
Gemifloxacin Gemifloxacin The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Gemifloxacin.
Progesterone Progesterone The metabolism of Progesterone can be decreased when combined with Protriptyline.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Protriptyline is combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Protriptyline can be increased when combined with Infliximab.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Protriptyline.
Trospium Trospium Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan Bosentan Protriptyline may decrease the antihypertensive activities of Bosentan.
Cinacalcet Cinacalcet The metabolism of Protriptyline can be decreased when combined with Cinacalcet.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Protriptyline.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Protriptyline is combined with Eszopiclone.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection Protriptyline may decrease the hypoglycemic activities of Insulin aspart.
Solifenacin Solifenacin Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Voriconazole Voriconazole The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Voriconazole.
Dextroamphetamine Dextroamphetamine The therapeutic efficacy of Protriptyline can be increased when used in combination with Amphetamine.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Protriptyline can be decreased when combined with Peginterferon alfa-2b.
Pramlintide Injection Pramlintide Injection Protriptyline may decrease the hypoglycemic activities of Pramlintide.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
Exenatide Injection Exenatide Injection Protriptyline may decrease the hypoglycemic activities of Exenatide.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Ibandronate.
Isocarboxazid Isocarboxazid Protriptyline may increase the serotonergic activities of Isocarboxazid.
Ramelteon Ramelteon The risk or severity of adverse effects can be increased when Protriptyline is combined with Ramelteon.
Darifenacin Darifenacin The metabolism of Protriptyline can be decreased when combined with Darifenacin.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Protriptyline is combined with Fentanyl.
Pregabalin Pregabalin The therapeutic efficacy of Protriptyline can be increased when used in combination with Pregabalin.
Phenylephrine Phenylephrine Protriptyline may increase the vasopressor activities of Phenylephrine.
Tipranavir Tipranavir The metabolism of Protriptyline can be decreased when combined with Tipranavir.
Felbamate Felbamate The risk or severity of adverse effects can be increased when Protriptyline is combined with Felbamate.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection Protriptyline may decrease the hypoglycemic activities of Insulin detemir.
Ranolazine Ranolazine The serum concentration of Protriptyline can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Protriptyline can be increased when combined with Abatacept.
Rasagiline Rasagiline Rasagiline may increase the serotonergic activities of Protriptyline.
Imatinib Imatinib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Imatinib.
Sitagliptin Sitagliptin Protriptyline may decrease the hypoglycemic activities of Sitagliptin.
Gefitinib Gefitinib The metabolism of Protriptyline can be decreased when combined with Gefitinib.
Albuterol Albuterol The risk or severity of hypertension can be increased when Protriptyline is combined with Salbutamol.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Protriptyline is combined with Paliperidone.
Bortezomib Bortezomib The risk or severity of QTc prolongation can be increased when Bortezomib is combined with Protriptyline.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection Protriptyline may decrease the hypoglycemic activities of Insulin glulisine.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Oxaliplatin.
Posaconazole Posaconazole The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Posaconazole.
Primaquine Primaquine The metabolism of Protriptyline can be decreased when combined with Primaquine.
Aliskiren Aliskiren Protriptyline may decrease the antihypertensive activities of Aliskiren.
Bismuth Subsalicylate Bismuth Subsalicylate Protriptyline may increase the neurotoxic activities of Bismuth subsalicylate.
Dimenhydrinate Dimenhydrinate The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Dimenhydrinate.
Lisdexamfetamine Lisdexamfetamine The therapeutic efficacy of Protriptyline can be increased when used in combination with Lisdexamfetamine.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
Vorinostat Vorinostat The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Vorinostat.
Sorafenib Sorafenib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Sorafenib.
Sunitinib Sunitinib Protriptyline may decrease the hypoglycemic activities of Sunitinib.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
Lapatinib Lapatinib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Lapatinib.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Protriptyline is combined with Levocetirizine.
Dasatinib Dasatinib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Dasatinib.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Protriptyline.
Temsirolimus Temsirolimus The metabolism of Protriptyline can be decreased when combined with Temsirolimus.
Nilotinib Nilotinib The metabolism of Protriptyline can be decreased when combined with Nilotinib.
Toremifene Toremifene The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Toremifene.
Desmopressin Desmopressin The risk or severity of hyponatremia and water intoxication can be increased when Protriptyline is combined with Desmopressin.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Protriptyline.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Protriptyline.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Arsenic trioxide.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Protriptyline is combined with Desvenlafaxine.
Cevimeline Cevimeline The metabolism of Protriptyline can be decreased when combined with Cevimeline.
Nebivolol Nebivolol The risk or severity of hypertension can be increased when Protriptyline is combined with Nebivolol.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Protriptyline.
Certolizumab Injection Certolizumab Injection The metabolism of Protriptyline can be increased when combined with Certolizumab pegol.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Protriptyline.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Protriptyline is combined with Midazolam.
Naltrexone Injection Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Protriptyline is combined with Naltrexone.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Protriptyline is combined with Milnacipran.
Sodium Phosphate Sodium Phosphate The risk or severity of seizure can be increased when Protriptyline is combined with Sodium phosphate, monobasic.
Fesoterodine Fesoterodine Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Degarelix.
Betaxolol Betaxolol The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Betaxolol.
Iloperidone Iloperidone The risk or severity of adverse effects can be increased when Protriptyline is combined with Iloperidone.
Lacosamide Lacosamide The risk or severity of adverse effects can be increased when Protriptyline is combined with Lacosamide.
Everolimus Everolimus The metabolism of Protriptyline can be decreased when combined with Everolimus.
Dronedarone Dronedarone Dronedarone may increase the QTc-prolonging activities of Protriptyline.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Protriptyline.
Palonosetron Injection Palonosetron Injection The risk or severity of adverse effects can be increased when Protriptyline is combined with Palonosetron.
Saxagliptin Saxagliptin Protriptyline may decrease the hypoglycemic activities of Saxagliptin.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Telavancin.
Romidepsin Injection Romidepsin Injection The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Romidepsin.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
Golimumab Injection Golimumab Injection The metabolism of Protriptyline can be increased when combined with Golimumab.
Pazopanib Pazopanib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Pazopanib.
Asenapine Asenapine The risk or severity of adverse effects can be increased when Protriptyline is combined with Asenapine.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Protriptyline is combined with Vigabatrin.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Protriptyline is combined with Oxymorphone.
Liraglutide Injection Liraglutide Injection Protriptyline may decrease the hypoglycemic activities of Liraglutide.
Tocilizumab Injection Tocilizumab Injection The metabolism of Protriptyline can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine The risk or severity of seizure can be increased when Protriptyline is combined with Dalfampridine.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Eribulin.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Protriptyline.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Protriptyline is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Protriptyline can be decreased when combined with Acetaminophen.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Protriptyline.
Terbutaline Injection Terbutaline Injection The risk or severity of hypertension can be increased when Protriptyline is combined with Terbutaline.
Linagliptin Linagliptin Protriptyline may decrease the hypoglycemic activities of Linagliptin.
Rilpivirine Rilpivirine The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Rilpivirine.
Potassium Iodide Potassium Iodide The risk or severity of Cardiac Arrhythmia can be increased when Potassium Iodide is combined with Protriptyline.
Cyclophosphamide Injection Cyclophosphamide Injection Protriptyline may increase the neurotoxic activities of Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Protriptyline can be decreased when combined with Abiraterone.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Triptorelin.
Vandetanib Vandetanib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Vandetanib.
Clobazam Clobazam The metabolism of Clobazam can be decreased when combined with Protriptyline.
Vemurafenib Vemurafenib The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Protriptyline.
Crizotinib Crizotinib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Crizotinib.
Cabergoline Cabergoline The risk or severity of adverse effects can be increased when Cabergoline is combined with Protriptyline.
Ambrisentan Ambrisentan Protriptyline may decrease the antihypertensive activities of Ambrisentan.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Protriptyline is combined with Tiagabine.
Mirabegron Mirabegron The metabolism of Mirabegron can be decreased when combined with Protriptyline.
Lorcaserin Lorcaserin Protriptyline may decrease the hypoglycemic activities of Mecasermin.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Bedaquiline.
Alogliptin Alogliptin Protriptyline may decrease the hypoglycemic activities of Alogliptin.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Protriptyline.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Protriptyline is combined with Pomalidomide.
Canagliflozin Canagliflozin Protriptyline may decrease the hypoglycemic activities of Canagliflozin.
Dabrafenib Dabrafenib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Protriptyline can be decreased when combined with Ospemifene.
Levomilnacipran Levomilnacipran The risk or severity of adverse effects can be increased when Protriptyline is combined with Levomilnacipran.
Vortioxetine Vortioxetine The risk or severity of adverse effects can be increased when Protriptyline is combined with Vortioxetine.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Protriptyline.
Ketorolac Injection Ketorolac Injection The risk or severity of hypertension can be increased when Protriptyline is combined with Ketorolac.
Dapagliflozin Dapagliflozin Protriptyline may decrease the hypoglycemic activities of Dapagliflozin.
Apremilast Apremilast The metabolism of Protriptyline can be increased when combined with Apremilast.
Droxidopa Droxidopa Protriptyline may increase the vasopressor activities of Droxidopa.
Ceritinib Ceritinib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Protriptyline can be increased when combined with Siltuximab.
Albiglutide Injection Albiglutide Injection Protriptyline may decrease the hypoglycemic activities of Albiglutide.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Protriptyline is combined with Eslicarbazepine.
Oritavancin Injection Oritavancin Injection The metabolism of Protriptyline can be decreased when combined with Oritavancin.
Empagliflozin Empagliflozin Protriptyline may decrease the hypoglycemic activities of Empagliflozin.
Hydrocodone Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
Suvorexant Suvorexant Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Dulaglutide Injection Dulaglutide Injection Protriptyline may decrease the hypoglycemic activities of Dulaglutide.
Methamphetamine Methamphetamine The therapeutic efficacy of Protriptyline can be increased when used in combination with Metamfetamine.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Protriptyline is combined with Tasimelteon.
Riociguat Riociguat Protriptyline may decrease the antihypertensive activities of Riociguat.
Secukinumab Injection Secukinumab Injection The metabolism of Protriptyline can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of adverse effects can be increased when Protriptyline is combined with Risperidone.
Insulin Human Inhalation Insulin Human Inhalation Protriptyline may decrease the hypoglycemic activities of Insulin human.
Lenvatinib Lenvatinib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Protriptyline can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Protriptyline can be decreased when combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Protriptyline.
Ivabradine Ivabradine The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Ivabradine.
Macitentan Macitentan Protriptyline may decrease the antihypertensive activities of Macitentan.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Protriptyline is combined with Flibanserin.
Rolapitant Rolapitant The metabolism of Protriptyline can be decreased when combined with Rolapitant.
Brexpiprazole Brexpiprazole The risk or severity of adverse effects can be increased when Protriptyline is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Ziprasidone.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Protriptyline is combined with Cariprazine.
Eluxadoline Eluxadoline The risk or severity of serotonin syndrome can be increased when Protriptyline is combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection Protriptyline may decrease the hypoglycemic activities of Insulin degludec.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Protriptyline.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Protriptyline is combined with Brivaracetam.
Cobicistat Cobicistat The metabolism of Protriptyline can be decreased when combined with Cobicistat.
Midodrine Midodrine Midodrine may increase the vasopressor activities of Protriptyline.
Selexipag Selexipag Protriptyline may decrease the antihypertensive activities of Selexipag.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Protriptyline is combined with Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.
Furosemide Injection Furosemide Injection Protriptyline may decrease the antihypertensive activities of Furosemide.
Rucaparib Rucaparib The metabolism of Protriptyline can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Protriptyline may decrease the hypoglycemic activities of Lixisenatide.
Ribociclib Ribociclib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Ribociclib.
Doxepin (Insomnia) Doxepin (Insomnia) Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Deutetrabenazine Deutetrabenazine The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Deutetrabenazine.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Protriptyline.
Safinamide Safinamide Protriptyline may increase the serotonergic activities of Safinamide.
Midostaurin Midostaurin The metabolism of Protriptyline can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Protriptyline can be decreased when combined with Enasidenib.
Delafloxacin Delafloxacin The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Delafloxacin.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Protriptyline.
Semaglutide Injection Semaglutide Injection Protriptyline may decrease the hypoglycemic activities of Semaglutide.
Tetrabenazine Tetrabenazine The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Tetrabenazine.
Ertugliflozin Ertugliflozin Protriptyline may decrease the hypoglycemic activities of Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Lofexidine Lofexidine The therapeutic efficacy of Protriptyline can be increased when used in combination with Lofexidine.
Eliglustat Eliglustat The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Eliglustat.
Encorafenib Encorafenib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Encorafenib.
Ivosidenib Ivosidenib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Ivosidenib.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Protriptyline.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Protriptyline.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Protriptyline.
Dacomitinib Dacomitinib The metabolism of Protriptyline can be decreased when combined with Dacomitinib.
Stiripentol Stiripentol The risk or severity of adverse effects can be increased when Protriptyline is combined with Stiripentol.
Gilteritinib Gilteritinib The therapeutic efficacy of Protriptyline can be decreased when used in combination with Gilteritinib.
Glasdegib Glasdegib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Glasdegib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection Protriptyline may increase the neurotoxic activities of Paclitaxel.
Rifamycin Rifamycin The metabolism of Protriptyline can be decreased when combined with Rifamycin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Protriptyline can be increased when combined with Emapalumab.
Siponimod Siponimod The risk or severity of hypertension can be increased when Protriptyline is combined with Siponimod.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Protriptyline is combined with Brexanolone.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Protriptyline.
Triclabendazole Triclabendazole The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Triclabendazole.
Entrectinib Entrectinib The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Entrectinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Protriptyline.
Pitolisant Pitolisant The therapeutic efficacy of Pitolisant can be decreased when used in combination with Protriptyline.
Fedratinib Fedratinib The metabolism of Protriptyline can be decreased when combined with Fedratinib.
Lefamulin Lefamulin Protriptyline may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection Phenytoin Injection The risk or severity of adverse effects can be increased when Phenytoin is combined with Protriptyline.
Fosphenytoin Injection Fosphenytoin Injection The risk or severity of adverse effects can be increased when Protriptyline is combined with Fosphenytoin.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Protriptyline is combined with Lumateperone.
Lasmiditan Lasmiditan The risk or severity of serotonin syndrome can be increased when Protriptyline is combined with Lasmiditan.
Cenobamate Cenobamate The therapeutic efficacy of Cenobamate can be decreased when used in combination with Protriptyline.
Selpercatinib Selpercatinib The risk or severity of hypertension can be increased when Protriptyline is combined with Selpercatinib.
Lemborexant Lemborexant The risk or severity of adverse effects can be increased when Protriptyline is combined with Lemborexant.
Fenfluramine Fenfluramine The risk or severity of serotonin syndrome can be increased when Protriptyline is combined with Fenfluramine.
Fostemsavir Fostemsavir The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Fostemsavir.
Octreotide Octreotide The risk or severity of QTc prolongation can be increased when Octreotide is combined with Protriptyline.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Protriptyline is combined with Naxitamab.
Relugolix Relugolix The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Relugolix.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Protriptyline is combined with Viloxazine.
Theophylline Theophylline The metabolism of Protriptyline can be decreased when combined with Theophylline.
Fenoprofen Fenoprofen The risk or severity of hypertension can be increased when Protriptyline is combined with Fenoprofen.
Indomethacin Indomethacin The risk or severity of hypertension can be increased when Indomethacin is combined with Protriptyline.
Mefenamic Acid Mefenamic Acid The risk or severity of hypertension can be increased when Protriptyline is combined with Mefenamic acid.
Naproxen Naproxen The risk or severity of hypertension can be increased when Protriptyline is combined with Naproxen.
Tolmetin Tolmetin The risk or severity of hypertension can be increased when Protriptyline is combined with Tolmetin.
Sulindac Sulindac The risk or severity of hypertension can be increased when Protriptyline is combined with Sulindac.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Protriptyline.
Hydroxyurea Hydroxyurea The metabolism of Protriptyline can be decreased when combined with Hydroxyurea.
Phenobarbital Phenobarbital The risk or severity of adverse effects can be increased when Protriptyline is combined with Phenobarbital.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Protriptyline is combined with Metaxalone.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Protriptyline is combined with Levorphanol.
Primidone Primidone The metabolism of Protriptyline can be increased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Protriptyline is combined with Methsuximide.
Diethylpropion Diethylpropion The therapeutic efficacy of Protriptyline can be increased when used in combination with Diethylpropion.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Protriptyline.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Protriptyline is combined with Diazepam.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Protriptyline is combined with Oxazepam.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Protriptyline is combined with Flurazepam.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Protriptyline is combined with Clorazepic acid.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Protriptyline.
Phenoxybenzamine Phenoxybenzamine The risk or severity of hypertension can be increased when Protriptyline is combined with Phenoxybenzamine.
Amantadine Amantadine The risk or severity of serotonin syndrome can be increased when Protriptyline is combined with Amantadine.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Protriptyline.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Protriptyline is combined with Meprobamate.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Protriptyline is combined with Chlordiazepoxide.
Bromocriptine Bromocriptine Protriptyline may increase the vasopressor activities of Bromocriptine.
Metaproterenol Metaproterenol The risk or severity of hypertension can be increased when Protriptyline is combined with Orciprenaline.
Tranylcypromine Tranylcypromine The metabolism of Tranylcypromine can be decreased when combined with Protriptyline.
Phenelzine Phenelzine Protriptyline may increase the serotonergic activities of Phenelzine.
Procarbazine Procarbazine Procarbazine may increase the serotonergic activities of Protriptyline.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Protriptyline is combined with Ergoloid mesylate.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
Prochlorperazine Prochlorperazine The serum concentration of Prochlorperazine can be increased when it is combined with Protriptyline.
Thioridazine Thioridazine The serum concentration of Thioridazine can be increased when it is combined with Protriptyline.
Trifluoperazine Trifluoperazine The serum concentration of Trifluoperazine can be increased when it is combined with Protriptyline.
Sulfadiazine Sulfadiazine Protriptyline may decrease the hypoglycemic activities of Sulfadiazine.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Protriptyline is combined with Oxycodone.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Protriptyline.
Oxybutynin Oxybutynin Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine Benztropine Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline Maprotiline Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Ibuprofen Ibuprofen The risk or severity of hypertension can be increased when Protriptyline is combined with Ibuprofen.
Trihexyphenidyl Trihexyphenidyl Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The serum concentration of Perphenazine can be increased when it is combined with Protriptyline.
Fluphenazine Fluphenazine The serum concentration of Fluphenazine can be increased when it is combined with Protriptyline.
Phentermine Phentermine The therapeutic efficacy of Protriptyline can be increased when used in combination with Phentermine.
Methylphenidate Methylphenidate The risk or severity of adverse effects can be increased when Methylphenidate is combined with Protriptyline.
Amoxapine Amoxapine The metabolism of Amoxapine can be decreased when combined with Protriptyline.
Sulfasalazine Sulfasalazine The risk or severity of hypertension can be increased when Protriptyline is combined with Sulfasalazine.
Doxorubicin Doxorubicin The metabolism of Protriptyline can be decreased when combined with Doxorubicin.
Carbamazepine Carbamazepine The risk or severity of adverse effects can be increased when Protriptyline is combined with Carbamazepine.
Molindone Molindone The risk or severity of adverse effects can be increased when Protriptyline is combined with Molindone.
Methyldopa Methyldopa The risk or severity of hypertension can be increased when Protriptyline is combined with Methyldopa.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Protriptyline.
Prazosin Prazosin Protriptyline may decrease the antihypertensive activities of Prazosin.
Hydralazine Hydralazine Protriptyline may decrease the antihypertensive activities of Hydralazine.
Cimetidine Cimetidine The metabolism of Protriptyline can be decreased when combined with Cimetidine.
Warfarin Warfarin The risk or severity of adverse effects can be increased when Protriptyline is combined with Warfarin.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Protriptyline is combined with Clonazepam.
Loperamide Loperamide The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Loperamide.
Promethazine Promethazine The serum concentration of Protriptyline can be increased when it is combined with Promethazine.
Meclofenamate Meclofenamate The risk or severity of hypertension can be increased when Protriptyline is combined with Meclofenamic acid.
Digoxin Digoxin The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Digoxin.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Protriptyline is combined with Loxapine.
Chloroquine Chloroquine The metabolism of Protriptyline can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Protriptyline can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Protriptyline is combined with Ethosuximide.
Chlorothiazide Chlorothiazide Protriptyline may decrease the antihypertensive activities of Chlorothiazide.
Chlorthalidone Chlorthalidone Protriptyline may decrease the antihypertensive activities of Chlorthalidone.
Metolazone Metolazone Protriptyline may decrease the antihypertensive activities of Metolazone.
Clindamycin Injection Clindamycin Injection Protriptyline may increase the neurotoxic activities of Clindamycin.
Secobarbital Secobarbital The metabolism of Protriptyline can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Protriptyline.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Protriptyline.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Protriptyline.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Protriptyline.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Protriptyline.
Isoniazid Isoniazid The risk or severity of serotonin syndrome can be increased when Protriptyline is combined with Isoniazid.
Disopyramide Disopyramide The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Disopyramide.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Protriptyline.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Protriptyline.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Protriptyline.
Levothyroxine Levothyroxine The risk or severity of Cardiac Arrhythmia and CNS stimulation can be increased when Levothyroxine is combined with Protriptyline.
Liothyronine Liothyronine The risk or severity of Cardiac Arrhythmia can be increased when Liothyronine is combined with Protriptyline.
Methimazole Methimazole The risk or severity of Cardiac Arrhythmia can be increased when Methimazole is combined with Protriptyline.
Propylthiouracil Propylthiouracil The risk or severity of Cardiac Arrhythmia can be increased when Propylthiouracil is combined with Protriptyline.
Chlorpropamide Chlorpropamide Protriptyline may decrease the hypoglycemic activities of Chlorpropamide.
Tolbutamide Tolbutamide Protriptyline may decrease the hypoglycemic activities of Tolbutamide.
Tolazamide Tolazamide Protriptyline may decrease the hypoglycemic activities of Tolazamide.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Protriptyline is combined with Dextromethorphan.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Protriptyline is combined with Cyclobenzaprine.
Niacin Niacin The metabolism of Protriptyline can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of CNS depression and hypotonia can be increased when Baclofen is combined with Protriptyline.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
Cyproheptadine Cyproheptadine The risk or severity of adverse effects can be increased when Protriptyline is combined with Cyproheptadine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Protriptyline.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Protriptyline is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Protriptyline is combined with Dexbrompheniramine.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Protriptyline is combined with Meclizine.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Hydrochlorothiazide.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Protriptyline is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Protriptyline is combined with Chlorzoxazone.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Protriptyline.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Protriptyline is combined with Methocarbamol.
Disulfiram Disulfiram The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Propranolol.
Minoxidil Minoxidil Protriptyline may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine Pseudoephedrine The therapeutic efficacy of Protriptyline can be increased when used in combination with Pseudoephedrine.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Protriptyline.
Nadolol Nadolol Protriptyline may decrease the antihypertensive activities of Nadolol.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Protriptyline is combined with Butorphanol.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Protriptyline is combined with Nalbuphine.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Protriptyline.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Protriptyline is combined with Trimethobenzamide.
Flavoxate Flavoxate Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Papaverine.
Fluorouracil Injection Fluorouracil Injection The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Fluorouracil.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Protriptyline is combined with Acetazolamide.
Calcitonin Salmon Injection Calcitonin Salmon Injection The risk or severity of Cardiac Arrhythmia can be increased when Salmon calcitonin is combined with Protriptyline.
Ketoconazole Ketoconazole The metabolism of Protriptyline can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Protriptyline is combined with Pyrantel.
Vincristine Injection Vincristine Injection Protriptyline may increase the neurotoxic activities of Vincristine.
Captopril Captopril Protriptyline may decrease the antihypertensive activities of Captopril.
Isoxsuprine Isoxsuprine The risk or severity of hypertension can be increased when Protriptyline is combined with Isoxsuprine.
Vinblastine Vinblastine The metabolism of Protriptyline can be decreased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Protriptyline can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Protriptyline.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Protriptyline is combined with Thiothixene.
Aspirin Aspirin The risk or severity of hypertension can be increased when Protriptyline is combined with Acetylsalicylic acid.
Salsalate Salsalate The risk or severity of hypertension can be increased when Protriptyline is combined with Salsalate.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Protriptyline is combined with Alprazolam.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Protriptyline.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Protriptyline is combined with Triazolam.
Dicyclomine Dicyclomine Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Diltiazem Diltiazem The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Diltiazem.
Nifedipine Nifedipine The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Nifedipine.
Timolol Timolol The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Timolol.
Verapamil Verapamil The metabolism of Protriptyline can be decreased when combined with Verapamil.
Atenolol Atenolol Protriptyline may decrease the antihypertensive activities of Atenolol.
Pindolol Pindolol The risk or severity of adverse effects can be increased when Protriptyline is combined with Pindolol.
Diflunisal Diflunisal The risk or severity of hypertension can be increased when Protriptyline is combined with Diflunisal.
Piroxicam Piroxicam The risk or severity of hypertension can be increased when Protriptyline is combined with Piroxicam.
Glyburide Glyburide Protriptyline may decrease the hypoglycemic activities of Glyburide.
Glipizide Glipizide Protriptyline may decrease the hypoglycemic activities of Glipizide.
Indapamide Indapamide The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Indapamide.
Pentamidine Injection Pentamidine Injection Protriptyline may decrease the hypoglycemic activities of Pentamidine.
Labetalol Labetalol The metabolism of Labetalol can be decreased when combined with Protriptyline.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Leuprolide.
Guanabenz Guanabenz The therapeutic efficacy of Guanabenz can be decreased when used in combination with Protriptyline.
Ketoprofen Ketoprofen The risk or severity of hypertension can be increased when Protriptyline is combined with Ketoprofen.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Protriptyline.
Enalapril Enalapril Protriptyline may decrease the antihypertensive activities of Enalapril.
Flurbiprofen Flurbiprofen The risk or severity of hypertension can be increased when Protriptyline is combined with Flurbiprofen.
Amiodarone Amiodarone The risk or severity of QTc prolongation can be increased when Amiodarone is combined with Protriptyline.
Buspirone Buspirone The risk or severity of serotonin syndrome can be increased when Protriptyline is combined with Buspirone.
Lovastatin Lovastatin The metabolism of Protriptyline can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Ciprofloxacin.
Mesalamine Mesalamine The risk or severity of hypertension can be increased when Mesalazine is combined with Protriptyline.
Diclofenac Diclofenac The risk or severity of hypertension can be increased when Protriptyline is combined with Diclofenac.
Fluoxetine Fluoxetine The serum concentration of Fluoxetine can be increased when it is combined with Protriptyline.
Nimodipine Nimodipine The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Nimodipine.
Clozapine Clozapine The metabolism of Clozapine can be decreased when combined with Protriptyline.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Protriptyline is combined with Estazolam.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Protriptyline.
Ofloxacin Ofloxacin The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Ofloxacin.
Didanosine Didanosine Protriptyline may increase the neurotoxic activities of Didanosine.
Clarithromycin Clarithromycin The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Clarithromycin.
Benazepril Benazepril Protriptyline may decrease the antihypertensive activities of Benazepril.
Etodolac Etodolac The risk or severity of hypertension can be increased when Protriptyline is combined with Etodolac.
Felodipine Felodipine The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Felodipine.
Fosinopril Fosinopril Protriptyline may decrease the antihypertensive activities of Fosinopril.
Nabumetone Nabumetone The risk or severity of hypertension can be increased when Protriptyline is combined with Nabumetone.
Quinapril Quinapril Protriptyline may decrease the antihypertensive activities of Quinapril.
Ramipril Ramipril Protriptyline may decrease the antihypertensive activities of Ramipril.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Protriptyline.
Amlodipine Amlodipine Protriptyline may decrease the antihypertensive activities of Amlodipine.
Teniposide Injection Teniposide Injection Protriptyline may increase the neurotoxic activities of Teniposide.
Itraconazole Itraconazole The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Itraconazole.
Lisinopril Lisinopril Protriptyline may decrease the antihypertensive activities of Lisinopril.
Oxaprozin Oxaprozin The risk or severity of hypertension can be increased when Protriptyline is combined with Oxaprozin.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Protriptyline.
Bisoprolol Bisoprolol Protriptyline may decrease the antihypertensive activities of Bisoprolol.
Zolpidem Zolpidem Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin Protriptyline may decrease the antihypertensive activities of Doxazosin.
Terazosin Terazosin Protriptyline may decrease the antihypertensive activities of Terazosin.
Isradipine Isradipine The risk or severity of QTc prolongation can be increased when Isradipine is combined with Protriptyline.
Omeprazole Omeprazole The metabolism of Protriptyline can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Protriptyline.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Protriptyline is combined with Gabapentin.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Protriptyline.
Venlafaxine Venlafaxine The metabolism of Protriptyline can be decreased when combined with Venlafaxine.
Stavudine Stavudine Protriptyline may increase the neurotoxic activities of Stavudine.
Fluvoxamine Fluvoxamine The metabolism of Protriptyline can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of adverse effects can be increased when Protriptyline is combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Protriptyline is combined with Lamotrigine.
Losartan Losartan The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Losartan.
Tramadol Tramadol The risk or severity of serotonin syndrome can be increased when Protriptyline is combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Protriptyline can be decreased when combined with Vinorelbine.
Moexipril Moexipril The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Moexipril.
Lansoprazole Lansoprazole The metabolism of Protriptyline can be decreased when combined with Lansoprazole.
Nicardipine Nicardipine The metabolism of Nicardipine can be decreased when combined with Protriptyline.
Bupropion Bupropion The risk or severity of seizure can be increased when Protriptyline is combined with Bupropion.
Ticlopidine Ticlopidine The metabolism of Protriptyline can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Saquinavir.
Metformin Metformin Protriptyline may decrease the hypoglycemic activities of Metformin.
Nisoldipine Nisoldipine Protriptyline may decrease the antihypertensive activities of Nisoldipine.
Riluzole Riluzole The risk or severity of adverse effects can be increased when Protriptyline is combined with Riluzole.
Acarbose Acarbose Protriptyline may decrease the hypoglycemic activities of Acarbose.
Glimepiride Glimepiride Protriptyline may decrease the hypoglycemic activities of Glimepiride.
Ritonavir Ritonavir The metabolism of Protriptyline can be decreased when combined with Ritonavir.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Protriptyline.
Mirtazapine Mirtazapine Protriptyline may increase the serotonergic activities of Mirtazapine.
Trandolapril Trandolapril Protriptyline may decrease the antihypertensive activities of Trandolapril.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Protriptyline.
Valsartan Valsartan Protriptyline may decrease the antihypertensive activities of Valsartan.
Insulin Lispro Injection Insulin Lispro Injection Protriptyline may decrease the hypoglycemic activities of Insulin lispro.
Pramipexole Pramipexole Protriptyline may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of adverse effects can be increased when Protriptyline is combined with Donepezil.
Nelfinavir Nelfinavir The risk or severity of QTc prolongation can be increased when Nelfinavir is combined with Protriptyline.
Azithromycin Azithromycin The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Azithromycin.
Carvedilol Carvedilol Protriptyline may decrease the antihypertensive activities of Carvedilol.
Selegiline Selegiline Protriptyline may increase the serotonergic activities of Selegiline.
Bicalutamide Bicalutamide The metabolism of Protriptyline can be decreased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of adverse effects can be increased when Protriptyline is combined with Sertraline.
Propafenone Propafenone The metabolism of Propafenone can be decreased when combined with Protriptyline.
Irbesartan Irbesartan Protriptyline may decrease the antihypertensive activities of Irbesartan.
Tamsulosin Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Protriptyline.
Ropinirole Ropinirole Protriptyline may increase the sedative activities of Ropinirole.
Finasteride Finasteride The risk or severity of hypertension can be increased when Protriptyline is combined with Finasteride.
Quetiapine Quetiapine Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Protriptyline.
Paroxetine Paroxetine The metabolism of Paroxetine can be decreased when combined with Protriptyline.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Protriptyline.
Citalopram Citalopram The risk or severity of adverse effects can be increased when Protriptyline is combined with Citalopram.
Efavirenz Efavirenz The risk or severity of adverse effects can be increased when Efavirenz is combined with Protriptyline.
Sildenafil Sildenafil The metabolism of Protriptyline can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone Protriptyline may decrease the hypoglycemic activities of Pioglitazone.
Celecoxib Celecoxib The metabolism of Protriptyline can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone Protriptyline may decrease the hypoglycemic activities of Rosiglitazone.
Tolterodine Tolterodine Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide Thalidomide Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Balsalazide Balsalazide The risk or severity of hypertension can be increased when Protriptyline is combined with Balsalazide.
Nateglinide Nateglinide Protriptyline may decrease the hypoglycemic activities of Nateglinide.
Galantamine Galantamine The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Galantamine.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Protriptyline is combined with Levetiracetam.
Rabeprazole Rabeprazole The metabolism of Protriptyline can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Protriptyline can be decreased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists