Rilpivirine

Rilpivirine is used along with other medications to treat human immunodeficiency virus type 1 (HIV-1) in certain adults and children 12 years of age and older who weigh at least 77 lb (35 kg) and have not received antiretroviral treatment in the past. It is also used along with cabotegravir (Vocabria) as a short-term treatment of HIV-1 infection in certain adults. Rilpivirine is in a class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It works by decreasing the amount of HIV in the blood. Although rilpivirine does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting (spreading) the HIV virus to other people.

Rilpivirine comes as a tablet to take by mouth. It is usually taken with a meal (not just a protein drink) once a day. When rilpivirine is taken along with cabotegravir, it is usually taken once daily with a meal. Take rilpivirine alone or along with cabotegravir at around the same time every day. Rilpivirine is taken along with cabotegravir for about one month (for at least 28 days) prior to starting treatment with the long-acting injectable forms of these medications or for up to 2 months if the injectable treatment schedule is missed for more than 7 days. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take rilpivirine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Rilpivirine controls HIV but does not cure it. Continue to take rilpivirine even if you feel well. Do not stop taking rilpivirine without talking to your doctor. When your supply of rilpivirine starts to run low, get more from your doctor or pharmacist. If you miss doses or stop taking rilpivirine, your condition may become more difficult to treat.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking rilpivirine,

• tell your doctor and pharmacist if you are allergic to rilpivirine, any other medications, or any of the ingredients in rilpivirine tablets. Ask your pharmacist for a list of the ingredients.

• tell your doctor if you are taking dexamethasone (Decadron); medications for seizures including carbamazepine (Carbatrol, Epitol, Euetro, Tegretol, Teril), oxcarbazepine (Trileptal), phenobarbital (Luminal), or phenytoin (Dilantin, Phenytek); proton pump inhibitors including dexlansoprazole (Dexilant), esomeprazole (Nexium, Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), or rabeprazole (Aciphex); rifampin (Rifater, Rifamate, Rimactane, Rifadin); rifapentine (Priftin); and St. John's wort. Your doctor will probably tell you not to take rilpivirine if you are taking one or more of these medications.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antifungal medications, including fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend); amiodarone (Nexterone, Pacerone); anagrelide (Agrylin); chloroquine; chlorpromazine; cilostazol; ciprofloxacin (Cipro); citalopram (Celexa); clarithromycin (Biaxin); disopyramide (Norpace); dofetilide (Tikosyn); donepezil (Aricept); erythromycin (E-Mycin, Eryc, Ery-Tab, PCE, Pediazole); flecainide (Tambocor); haloperidol (Haldol); ibutilide (Corvert); levofloxacin; methadone (Dolophine); moxifloxacin (Velox); nelfinavir (Viracept); ondansetron (Zuplenz, Zofran); other NNRTIs medications to treat HIV/AIDS; pentamidine (NebuPent, Pentam); pimozide (Orap); procainamide; quinidine (in Nuedexta); rifabutin (Mycobutin); sotalol (Betapace, Sorine, Sotylize); telithromycin (Ketek); and thioridazine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with rilpivirine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

• if you are taking antacids containing calcium, magnesium, or aluminum (Maalox, Mylanta, Tums, others), take them at least 2 hours before or 4 hours after rilpivirine.

• if you are taking a medication for indigestion, heartburn, or ulcers such as cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), or ranitidine (Zantac), take it at least 12 hours before or at least 4 hours after rilpivirine.

• if you are taking didanosine (Videx), take it at least2 hours before or at least 4 hours after rilpivirine.

• tell your doctor if you have or have ever had depression or other mental illness, liver disease, including hepatitis B or C, or kidney disease.

• tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking rilpivirine, call your doctor. Tell your doctor if you are breastfeeding. You should not breastfeed if you are infected with HIV or if you are taking rilpivirine.

• you should know that your body fat may increase or move to different areas of your body such as your breasts, upper back and neck, or around the middle of your body. Loss of fat from the legs, arms, and face can also happen.

• you should know that rilpivirine may cause changes in your thoughts, behavior, or mental health. Call your doctor immediately if you develop any of the following symptoms while you are taking rilpivirine: new or worsening depression; feeling sad, hopeless, anxious, or restless; or thinking about killing yourself or planning or trying to do so. Be sure your family knows which symptoms may be serious so that they can call your doctor if you are unable to seek treatment on your own.

• you should know that while you are taking medications to treat HIV infection, your immune system may get stronger and begin to fight other infections that were already in your body or cause other conditions to occur. This may cause you to develop symptoms of those infections or conditions. If you have new or worsening symptoms after starting treatment with rilpivirine, be sure to tell your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it, with a meal. However, if it has been more than 12 hours since your last dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Rilpivirine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • difficulty falling asleep or staying asleep

  • headache

  • nausea

  • vomiting

  • dizziness

  • abdominal pain

  • drowsiness

• Some side effects can be serious. If you experience any of these symptoms, or those listed in the SPECIAL PRECAUTIONS section, call your doctor immediately:

  • rash

  • yellowing of skin or eyes, pain on the right side of the stomach, nausea, vomiting, light colored stools, dark colored urine

• Some side effects can be serious. If you experience any of these symptoms stop taking rilpivirine and call your doctor immediately or get emergency medical treatment:

  • rash along with fever, swelling of the face, lips, mouth, tongue, or throat, blisters, trouble breathing or swallowing, mouth sores, redness or swelling of the eyes (conjunctivitis), pain on the right side of the stomach (abdominal) area, or dark colored urine

• Rilpivirine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to rilpivirine.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

Keep a supply of rilpivirine on hand. Do not wait until you run out of medication to refill your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Moxifloxacin	Moxifloxacin The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Moxifloxacin.
Repaglinide	Repaglinide The excretion of Rilpivirine can be decreased when combined with Repaglinide.
Leflunomide	Leflunomide Rilpivirine may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Delavirdine	Delavirdine The metabolism of Delavirdine can be decreased when combined with Rilpivirine.
Nevirapine	Nevirapine The metabolism of Nevirapine can be decreased when combined with Rilpivirine.
Atorvastatin	Atorvastatin The serum concentration of Atorvastatin can be increased when it is combined with Rilpivirine.
Dolasetron	Dolasetron The metabolism of Dolasetron can be decreased when combined with Rilpivirine.
Aminophylline	Aminophylline The metabolism of Aminophylline can be decreased when combined with Rilpivirine.
Anagrelide	Anagrelide The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Anagrelide.
Calcium Carbonate	Calcium Carbonate Calcium carbonate can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Rilpivirine.
Clopidogrel	Clopidogrel The metabolism of Rilpivirine can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The serum concentration of Rilpivirine can be increased when it is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) Rilpivirine may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate	Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Rilpivirine.
Magnesium Hydroxide	Magnesium Hydroxide Magnesium hydroxide can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium Oxide	Magnesium Oxide Magnesium oxide can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Penbutolol	Penbutolol The metabolism of Acebutolol can be decreased when combined with Rilpivirine.
Ranitidine	Ranitidine Ranitidine can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sumatriptan	Sumatriptan Rilpivirine may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus	Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Rilpivirine.
Tizanidine	Tizanidine The risk or severity of QTc prolongation can be increased when Tizanidine is combined with Rilpivirine.
Famotidine Injection	Famotidine Injection Famotidine can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fluconazole Injection	Fluconazole Injection The risk or severity of QTc prolongation can be increased when Fluconazole is combined with Rilpivirine.
Foscarnet Injection	Foscarnet Injection The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Rilpivirine.
Levofloxacin Injection	Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Levofloxacin.
Meperidine Injection	Meperidine Injection The metabolism of Meperidine can be decreased when combined with Rilpivirine.
Metoclopramide Injection	Metoclopramide Injection The metabolism of Metoclopramide can be decreased when combined with Rilpivirine.
Metronidazole Injection	Metronidazole Injection The risk or severity of QTc prolongation can be increased when Metronidazole is combined with Rilpivirine.
Altretamine	Altretamine The metabolism of Amphetamine can be decreased when combined with Rilpivirine.
Cyclosporine	Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Rilpivirine.
Ondansetron	Ondansetron The metabolism of Rilpivirine can be decreased when combined with Ondansetron.
Granisetron	Granisetron The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Granisetron.
Torsemide	Torsemide The excretion of Torasemide can be decreased when combined with Rilpivirine.
Olanzapine	Olanzapine Olanzapine can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dofetilide	Dofetilide The metabolism of Dofetilide can be decreased when combined with Rilpivirine.
Hydroxychloroquine	Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Hydroxychloroquine is combined with Rilpivirine.
Oxcarbazepine	Oxcarbazepine The serum concentration of Rilpivirine can be decreased when it is combined with Oxcarbazepine.
Pantoprazole	Pantoprazole The therapeutic efficacy of Rilpivirine can be decreased when used in combination with Pantoprazole.
Desloratadine	Desloratadine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Desloratadine.
Trimipramine	Trimipramine The metabolism of Rilpivirine can be decreased when combined with Trimipramine.
Tenofovir	Tenofovir The excretion of Tenofovir can be decreased when combined with Rilpivirine.
Sirolimus	Sirolimus The metabolism of Sirolimus can be decreased when combined with Rilpivirine.
Escitalopram	Escitalopram The metabolism of Escitalopram can be decreased when combined with Rilpivirine.
Zonisamide	Zonisamide The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Rilpivirine.
Aripiprazole	Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Rilpivirine.
Atomoxetine	Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Rilpivirine.
Ezetimibe	Ezetimibe Rilpivirine may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Atazanavir	Atazanavir The serum concentration of Rilpivirine can be increased when it is combined with Atazanavir.
Almotriptan	Almotriptan The metabolism of Almotriptan can be decreased when combined with Rilpivirine.
Eletriptan	Eletriptan The metabolism of Eletriptan can be decreased when combined with Rilpivirine.
Mefloquine	Mefloquine The risk or severity of QTc prolongation can be increased when Mefloquine is combined with Rilpivirine.
Rosuvastatin	Rosuvastatin Rilpivirine may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Vardenafil	Vardenafil The metabolism of Vardenafil can be decreased when combined with Rilpivirine.
Alfuzosin	Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Rilpivirine.
Tegaserod	Tegaserod The metabolism of Tegaserod can be decreased when combined with Rilpivirine.
Fosamprenavir	Fosamprenavir The serum concentration of Rilpivirine can be increased when it is combined with Fosamprenavir.
Gemifloxacin	Gemifloxacin The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Gemifloxacin.
Progesterone	Progesterone The metabolism of Progesterone can be decreased when combined with Rilpivirine.
Apomorphine Injection	Apomorphine Injection The metabolism of Rilpivirine can be decreased when combined with Apomorphine.
Protriptyline	Protriptyline The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Rilpivirine.
Duloxetine	Duloxetine The metabolism of Duloxetine can be decreased when combined with Rilpivirine.
Norethindrone	Norethindrone The metabolism of Norethisterone can be decreased when combined with Rilpivirine.
Bosentan	Bosentan The excretion of Bosentan can be decreased when combined with Rilpivirine.
Erlotinib	Erlotinib The metabolism of Erlotinib can be decreased when combined with Rilpivirine.
Eszopiclone	Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Rilpivirine.
Solifenacin	Solifenacin The metabolism of Solifenacin can be decreased when combined with Rilpivirine.
Voriconazole	Voriconazole The risk or severity of QTc prolongation can be increased when Voriconazole is combined with Rilpivirine.
Dextroamphetamine	Dextroamphetamine The metabolism of Amphetamine can be decreased when combined with Rilpivirine.
Ibandronate	Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Rilpivirine.
Darifenacin	Darifenacin The metabolism of Darifenacin can be decreased when combined with Rilpivirine.
Fentanyl	Fentanyl The metabolism of Fentanyl can be decreased when combined with Rilpivirine.
Pregabalin	Pregabalin The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Rilpivirine.
Tipranavir	Tipranavir The serum concentration of Rilpivirine can be increased when it is combined with Tipranavir.
Felbamate	Felbamate The risk or severity of QTc prolongation can be increased when Felbamate is combined with Rilpivirine.
Ranolazine	Ranolazine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Ranolazine.
Imatinib	Imatinib The metabolism of Imatinib can be decreased when combined with Rilpivirine.
Gefitinib	Gefitinib Rilpivirine may decrease the excretion rate of Gefitinib which could result in a higher serum level.
Albuterol	Albuterol The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Rilpivirine.
Paliperidone	Paliperidone The metabolism of Rilpivirine can be decreased when combined with Paliperidone.
Bortezomib	Bortezomib The metabolism of Bortezomib can be decreased when combined with Rilpivirine.
Clofarabine Injection	Clofarabine Injection Rilpivirine may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Influenza Vaccine, Live Intranasal	Influenza Vaccine, Live Intranasal The therapeutic efficacy of Typhoid Vaccine Live can be decreased when used in combination with Rilpivirine.
Live Shingles (Zoster) Vaccine (ZVL)	Live Shingles (Zoster) Vaccine (ZVL) The therapeutic efficacy of Varicella Zoster Vaccine (Live/attenuated) can be decreased when used in combination with Rilpivirine.
Oxaliplatin Injection	Oxaliplatin Injection Rilpivirine may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Posaconazole	Posaconazole The risk or severity of QTc prolongation can be increased when Posaconazole is combined with Rilpivirine.
Primaquine	Primaquine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Primaquine.
Darunavir	Darunavir The serum concentration of Rilpivirine can be increased when it is combined with Darunavir.
Dimenhydrinate	Dimenhydrinate The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Dimenhydrinate.
Lisdexamfetamine	Lisdexamfetamine The metabolism of Lisdexamfetamine can be decreased when combined with Rilpivirine.
Retapamulin	Retapamulin The metabolism of Retapamulin can be decreased when combined with Rilpivirine.
Vorinostat	Vorinostat The risk or severity of QTc prolongation can be increased when Vorinostat is combined with Rilpivirine.
Sorafenib	Sorafenib The metabolism of Sorafenib can be decreased when combined with Rilpivirine.
Sunitinib	Sunitinib The metabolism of Rilpivirine can be decreased when combined with Sunitinib.
Lapatinib	Lapatinib The risk or severity of QTc prolongation can be increased when Lapatinib is combined with Rilpivirine.
Levocetirizine	Levocetirizine The risk or severity of QTc prolongation can be increased when Levocetirizine is combined with Rilpivirine.
Dasatinib	Dasatinib The metabolism of Rilpivirine can be decreased when combined with Dasatinib.
Mexiletine	Mexiletine The metabolism of Mexiletine can be decreased when combined with Rilpivirine.
Ivermectin	Ivermectin Rilpivirine may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Rilpivirine.
Nilotinib	Nilotinib The metabolism of Nilotinib can be decreased when combined with Rilpivirine.
Toremifene	Toremifene The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Toremifene.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Arsenic trioxide.
Mitoxantrone Injection	Mitoxantrone Injection Rilpivirine may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Cevimeline	Cevimeline The metabolism of Cevimeline can be decreased when combined with Rilpivirine.
Nebivolol	Nebivolol The metabolism of Nebivolol can be decreased when combined with Rilpivirine.
Tretinoin	Tretinoin The metabolism of Tretinoin can be decreased when combined with Rilpivirine.
Flecainide	Flecainide The metabolism of Flecainide can be decreased when combined with Rilpivirine.
Ixabepilone Injection	Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Rilpivirine.
Irinotecan Injection	Irinotecan Injection The metabolism of Rilpivirine can be decreased when combined with Irinotecan.
Rufinamide	Rufinamide The metabolism of Rufinamide can be decreased when combined with Rilpivirine.
Midazolam	Midazolam The serum concentration of Midazolam can be increased when it is combined with Rilpivirine.
Dexlansoprazole	Dexlansoprazole Dexlansoprazole can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fesoterodine	Fesoterodine The metabolism of Rilpivirine can be decreased when combined with Fesoterodine.
Degarelix Injection	Degarelix Injection The risk or severity of QTc prolongation can be increased when Degarelix is combined with Rilpivirine.
Betaxolol	Betaxolol The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Betaxolol.
Iloperidone	Iloperidone The metabolism of Iloperidone can be decreased when combined with Rilpivirine.
Prasugrel	Prasugrel The metabolism of Prasugrel can be decreased when combined with Rilpivirine.
Lacosamide	Lacosamide The metabolism of Lacosamide can be decreased when combined with Rilpivirine.
Everolimus	Everolimus The metabolism of Everolimus can be decreased when combined with Rilpivirine.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be decreased when combined with Rilpivirine.
Dronedarone	Dronedarone The metabolism of Dronedarone can be decreased when combined with Rilpivirine.
Pralatrexate Injection	Pralatrexate Injection Rilpivirine may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection	Palonosetron Injection The metabolism of Palonosetron can be decreased when combined with Rilpivirine.
Telavancin Injection	Telavancin Injection The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Telavancin.
Romidepsin Injection	Romidepsin Injection The metabolism of Rilpivirine can be decreased when combined with Romidepsin.
Tapentadol	Tapentadol The metabolism of Tapentadol can be decreased when combined with Rilpivirine.
Topotecan	Topotecan Rilpivirine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pazopanib	Pazopanib The metabolism of Pazopanib can be decreased when combined with Rilpivirine.
Asenapine	Asenapine Asenapine can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pitavastatin	Pitavastatin Rilpivirine may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Albendazole	Albendazole The metabolism of Albendazole can be decreased when combined with Rilpivirine.
Oxymorphone	Oxymorphone The metabolism of Oxymorphone can be decreased when combined with Rilpivirine.
Eribulin Injection	Eribulin Injection The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Eribulin.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Rilpivirine.
Lurasidone	Lurasidone The risk or severity of QTc prolongation can be increased when Lurasidone is combined with Rilpivirine.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Rilpivirine.
Vilazodone	Vilazodone The metabolism of Vilazodone can be decreased when combined with Rilpivirine.
Terbutaline Injection	Terbutaline Injection The risk or severity of QTc prolongation can be increased when Terbutaline is combined with Rilpivirine.
Busulfan Injection	Busulfan Injection The metabolism of Busulfan can be decreased when combined with Rilpivirine.
Roflumilast	Roflumilast The metabolism of Roflumilast can be decreased when combined with Rilpivirine.
Linagliptin	Linagliptin The metabolism of Linagliptin can be decreased when combined with Rilpivirine.
Telaprevir	Telaprevir Rilpivirine may decrease the excretion rate of Glecaprevir which could result in a higher serum level.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Rilpivirine.
Triptorelin Injection	Triptorelin Injection The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Rilpivirine.
Rivaroxaban	Rivaroxaban Rilpivirine may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Rilpivirine.
Ruxolitinib	Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Rilpivirine.
Vandetanib	Vandetanib The metabolism of Vandetanib can be decreased when combined with Rilpivirine.
Clobazam	Clobazam The metabolism of Clobazam can be decreased when combined with Rilpivirine.
Vemurafenib	Vemurafenib The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Rilpivirine.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Rilpivirine.
Crizotinib	Crizotinib The metabolism of Crizotinib can be decreased when combined with Rilpivirine.
Cabergoline	Cabergoline The metabolism of Cabergoline can be decreased when combined with Rilpivirine.
Ambrisentan	Ambrisentan The excretion of Ambrisentan can be decreased when combined with Rilpivirine.
Mirabegron	Mirabegron The metabolism of Rilpivirine can be decreased when combined with Mirabegron.
Regorafenib	Regorafenib The metabolism of Regorafenib can be decreased when combined with Rilpivirine.
Bosutinib	Bosutinib The metabolism of Bosutinib can be decreased when combined with Rilpivirine.
Teriflunomide	Teriflunomide Rilpivirine may decrease the excretion rate of Teriflunomide which could result in a higher serum level.
Bedaquiline	Bedaquiline The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Bedaquiline.
Tofacitinib	Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Rilpivirine.
Alogliptin	Alogliptin The metabolism of Alogliptin can be decreased when combined with Rilpivirine.
Ponatinib	Ponatinib The metabolism of Rilpivirine can be decreased when combined with Ponatinib.
Pomalidomide	Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Rilpivirine.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Rilpivirine.
Apixaban	Apixaban Rilpivirine may decrease the excretion rate of Apixaban which could result in a higher serum level.
Dabrafenib	Dabrafenib The metabolism of Dabrafenib can be decreased when combined with Rilpivirine.
Ospemifene	Ospemifene The metabolism of Ospemifene can be decreased when combined with Rilpivirine.
Afatinib	Afatinib Rilpivirine may decrease the excretion rate of Afatinib which could result in a higher serum level.
Levomilnacipran	Levomilnacipran The metabolism of Rilpivirine can be decreased when combined with Levomilnacipran.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Rilpivirine.
Perampanel	Perampanel The metabolism of Perampanel can be decreased when combined with Rilpivirine.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Rilpivirine.
Lomitapide	Lomitapide The metabolism of Rilpivirine can be decreased when combined with Lomitapide.
Simeprevir	Simeprevir Rilpivirine may decrease the excretion rate of Simeprevir which could result in a higher serum level.
Sofosbuvir	Sofosbuvir Rilpivirine may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin	Dapagliflozin The metabolism of Rilpivirine can be decreased when combined with Dapagliflozin.
Ceritinib	Ceritinib The metabolism of Ceritinib can be decreased when combined with Rilpivirine.
Idelalisib	Idelalisib The metabolism of Idelalisib can be decreased when combined with Rilpivirine.
Testosterone Injection	Testosterone Injection Rilpivirine may decrease the excretion rate of Testosterone which could result in a higher serum level.
Vorapaxar	Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Rilpivirine.
Hydrocodone	Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Rilpivirine.
Suvorexant	Suvorexant The metabolism of Suvorexant can be decreased when combined with Rilpivirine.
Olaparib	Olaparib The metabolism of Olaparib can be decreased when combined with Rilpivirine.
Caspofungin Injection	Caspofungin Injection The excretion of Caspofungin can be decreased when combined with Rilpivirine.
Methamphetamine	Methamphetamine The metabolism of Metamfetamine can be decreased when combined with Rilpivirine.
Tasimelteon	Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Rilpivirine.
Riociguat	Riociguat Rilpivirine may decrease the excretion rate of Riociguat which could result in a higher serum level.
Nintedanib	Nintedanib The metabolism of Nintedanib can be decreased when combined with Rilpivirine.
Risperidone Injection	Risperidone Injection The metabolism of Rilpivirine can be decreased when combined with Risperidone.
Palbociclib	Palbociclib The metabolism of Palbociclib can be decreased when combined with Rilpivirine.
Lenvatinib	Lenvatinib Rilpivirine may decrease the excretion rate of Lenvatinib which could result in a higher serum level.
Panobinostat	Panobinostat The metabolism of Panobinostat can be decreased when combined with Rilpivirine.
Haloperidol Injection	Haloperidol Injection The risk or severity of QTc prolongation can be increased when Haloperidol is combined with Rilpivirine.
Ivabradine	Ivabradine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Ivabradine.
Sonidegib	Sonidegib The metabolism of Sonidegib can be decreased when combined with Rilpivirine.
Brexpiprazole	Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Rilpivirine.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Rilpivirine.
Cariprazine	Cariprazine The metabolism of Cariprazine can be decreased when combined with Rilpivirine.
Eluxadoline	Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Rilpivirine.
Cobimetinib	Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Rilpivirine.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Rilpivirine.
Osimertinib	Osimertinib The metabolism of Osimertinib can be decreased when combined with Rilpivirine.
Alectinib	Alectinib The metabolism of Alectinib can be decreased when combined with Rilpivirine.
Ixazomib	Ixazomib The metabolism of Ixazomib can be decreased when combined with Rilpivirine.
Brivaracetam Injection	Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Rilpivirine.
Venetoclax	Venetoclax The metabolism of Venetoclax can be decreased when combined with Rilpivirine.
Selexipag	Selexipag The excretion of Selexipag can be decreased when combined with Rilpivirine.
Diphenhydramine Injection	Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Rilpivirine.
Rucaparib	Rucaparib Rilpivirine may decrease the excretion rate of Rucaparib which could result in a higher serum level.
Ribociclib	Ribociclib The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Ribociclib.
Brigatinib	Brigatinib The metabolism of Brigatinib can be decreased when combined with Rilpivirine.
Doxepin (Insomnia)	Doxepin (Insomnia) Doxepin can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Deutetrabenazine	Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Rilpivirine.
Valbenazine	Valbenazine The metabolism of Valbenazine can be decreased when combined with Rilpivirine.
Midostaurin	Midostaurin The metabolism of Midostaurin can be decreased when combined with Rilpivirine.
Neratinib	Neratinib The metabolism of Neratinib can be decreased when combined with Rilpivirine.
Enasidenib	Enasidenib The metabolism of Enasidenib can be decreased when combined with Rilpivirine.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be decreased when combined with Rilpivirine.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Rilpivirine.
Delafloxacin	Delafloxacin Rilpivirine may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib	Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Rilpivirine.
Acalabrutinib	Acalabrutinib The metabolism of Acalabrutinib can be decreased when combined with Rilpivirine.
Letermovir	Letermovir The metabolism of Letermovir can be decreased when combined with Rilpivirine.
Tetrabenazine	Tetrabenazine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Tetrabenazine.
Ertugliflozin	Ertugliflozin Rilpivirine may decrease the excretion rate of Ertugliflozin which could result in a higher serum level.
Buprenorphine Injection	Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Rilpivirine.
Penicillamine	Penicillamine The excretion of Penicillamine can be decreased when combined with Rilpivirine.
Baricitinib	Baricitinib The metabolism of Baricitinib can be decreased when combined with Rilpivirine.
Lofexidine	Lofexidine The metabolism of Lofexidine can be decreased when combined with Rilpivirine.
Eliglustat	Eliglustat The metabolism of Eliglustat can be decreased when combined with Rilpivirine.
Encorafenib	Encorafenib The metabolism of Encorafenib can be decreased when combined with Rilpivirine.
Ivosidenib	Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Rilpivirine.
Lusutrombopag	Lusutrombopag Rilpivirine may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Elagolix	Elagolix The metabolism of Elagolix can be decreased when combined with Rilpivirine.
Tafenoquine	Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Rilpivirine.
Dacomitinib	Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Rilpivirine.
Duvelisib	Duvelisib Rilpivirine may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Talazoparib	Talazoparib Rilpivirine may decrease the excretion rate of Talazoparib which could result in a higher serum level.
Gilteritinib	Gilteritinib The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Gilteritinib.
Glasdegib	Glasdegib Rilpivirine may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Rilpivirine.
Prucalopride	Prucalopride The metabolism of Prucalopride can be decreased when combined with Rilpivirine.
Siponimod	Siponimod The metabolism of Siponimod can be decreased when combined with Rilpivirine.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Rilpivirine.
Esomeprazole Injection	Esomeprazole Injection Esomeprazole can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Alpelisib	Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Rilpivirine.
Cladribine	Cladribine Rilpivirine may decrease the excretion rate of Cladribine which could result in a higher serum level.
Darolutamide	Darolutamide Rilpivirine may decrease the excretion rate of Darolutamide which could result in a higher serum level.
Triclabendazole	Triclabendazole The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Triclabendazole.
Entrectinib	Entrectinib The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Entrectinib.
Pexidartinib	Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Rilpivirine.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Rilpivirine.
Pitolisant	Pitolisant The serum concentration of Rilpivirine can be decreased when it is combined with Pitolisant.
Lefamulin	Lefamulin Rilpivirine may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection	Phenytoin Injection The serum concentration of Rilpivirine can be decreased when it is combined with Phenytoin.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Rilpivirine can be increased when combined with Fosphenytoin.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Rilpivirine.
Voxelotor	Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Rilpivirine.
Ubrogepant	Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Rilpivirine.
Tazemetostat	Tazemetostat Rilpivirine may decrease the excretion rate of Tazemetostat which could result in a higher serum level.
Bempedoic Acid	Bempedoic Acid The excretion of Bempedoic acid can be decreased when combined with Rilpivirine.
Cenobamate	Cenobamate The serum concentration of Rilpivirine can be decreased when it is combined with Cenobamate.
Ozanimod	Ozanimod Rilpivirine may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib	Selumetinib Rilpivirine may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rimegepant	Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Rilpivirine.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Rilpivirine.
Remdesivir Injection	Remdesivir Injection The excretion of Remdesivir can be decreased when combined with Rilpivirine.
Ripretinib	Ripretinib Rilpivirine may decrease the excretion rate of Ripretinib which could result in a higher serum level.
Fostemsavir	Fostemsavir Rilpivirine may decrease the excretion rate of Fostemsavir which could result in a higher serum level.
Octreotide	Octreotide The risk or severity of QTc prolongation can be increased when Octreotide is combined with Rilpivirine.
Belantamab Mafodotin-blmf Injection	Belantamab Mafodotin-blmf Injection The excretion of Belantamab mafodotin can be decreased when combined with Rilpivirine.
Pralsetinib	Pralsetinib Rilpivirine may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Rilpivirine can be decreased when it is combined with Satralizumab.
Relugolix	Relugolix The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Relugolix.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Rilpivirine.
Theophylline	Theophylline The metabolism of Theophylline can be decreased when combined with Rilpivirine.
Trazodone	Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Rilpivirine.
Sodium Bicarbonate	Sodium Bicarbonate Sodium bicarbonate can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Phenobarbital	Phenobarbital The serum concentration of Rilpivirine can be decreased when it is combined with Phenobarbital.
Methotrexate Injection	Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Rilpivirine.
Methsuximide	Methsuximide The risk or severity of QTc prolongation can be increased when Methsuximide is combined with Rilpivirine.
Chlorpromazine	Chlorpromazine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Chlorpromazine.
Lorazepam	Lorazepam The metabolism of Lorazepam can be decreased when combined with Rilpivirine.
Amantadine	Amantadine The risk or severity of QTc prolongation can be increased when Amantadine is combined with Rilpivirine.
Codeine	Codeine The metabolism of Codeine can be decreased when combined with Rilpivirine.
Prochlorperazine	Prochlorperazine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Prochlorperazine.
Thioridazine	Thioridazine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Thioridazine.
Oxycodone	Oxycodone The metabolism of Oxycodone can be decreased when combined with Rilpivirine.
Methadone	Methadone The serum concentration of Methadone can be decreased when it is combined with Rilpivirine.
Benztropine	Benztropine The metabolism of Benzatropine can be decreased when combined with Rilpivirine.
Maprotiline	Maprotiline The metabolism of Maprotiline can be decreased when combined with Rilpivirine.
Orphenadrine	Orphenadrine The risk or severity of QTc prolongation can be increased when Orphenadrine is combined with Rilpivirine.
Perphenazine	Perphenazine The metabolism of Perphenazine can be decreased when combined with Rilpivirine.
Phentermine	Phentermine The metabolism of Phentermine can be decreased when combined with Rilpivirine.
Amoxapine	Amoxapine The metabolism of Rilpivirine can be decreased when combined with Amoxapine.
Sulfasalazine	Sulfasalazine Rilpivirine may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Doxorubicin	Doxorubicin The metabolism of Doxorubicin can be decreased when combined with Rilpivirine.
Dactinomycin	Dactinomycin Rilpivirine may decrease the excretion rate of Dactinomycin which could result in a higher serum level.
Carbamazepine	Carbamazepine The serum concentration of Rilpivirine can be decreased when it is combined with Carbamazepine.
Clonidine	Clonidine The metabolism of Clonidine can be decreased when combined with Rilpivirine.
Prazosin	Prazosin Rilpivirine may decrease the excretion rate of Prazosin which could result in a higher serum level.
Cimetidine	Cimetidine Cimetidine can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Warfarin	Warfarin The serum concentration of Warfarin can be increased when it is combined with Rilpivirine.
Loperamide	Loperamide The metabolism of Loperamide can be decreased when combined with Rilpivirine.
Promethazine	Promethazine Promethazine can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Daunorubicin	Daunorubicin Rilpivirine may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Nitrofurantoin	Nitrofurantoin Rilpivirine may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin	Digoxin The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Digoxin.
Chloroquine	Chloroquine The metabolism of Rilpivirine can be decreased when combined with Chloroquine.
Quinine	Quinine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Quinine.
Ethosuximide	Ethosuximide The risk or severity of QTc prolongation can be increased when Ethosuximide is combined with Rilpivirine.
Desipramine	Desipramine The metabolism of Rilpivirine can be decreased when combined with Desipramine.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Rilpivirine.
Imipramine	Imipramine The metabolism of Imipramine can be decreased when combined with Rilpivirine.
Quinidine	Quinidine The metabolism of Rilpivirine can be decreased when combined with Quinidine.
Procainamide	Procainamide The metabolism of Procainamide can be decreased when combined with Rilpivirine.
Rifampin	Rifampin The excretion of Rifampicin can be decreased when combined with Rilpivirine.
Disopyramide	Disopyramide The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Disopyramide.
Valproic Acid	Valproic Acid The metabolism of Valproic acid can be decreased when combined with Rilpivirine.
Tamoxifen	Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Rilpivirine.
Liothyronine	Liothyronine The excretion of Liothyronine can be decreased when combined with Rilpivirine.
Dextromethorphan	Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Rilpivirine.
Dinoprostone	Dinoprostone The excretion of Dinoprostone can be decreased when combined with Rilpivirine.
Doxylamine	Doxylamine The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Rilpivirine.
Cyproheptadine	Cyproheptadine The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Rilpivirine.
Clemastine	Clemastine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Clemastine.
Chlorpheniramine	Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Rilpivirine.
Brompheniramine	Brompheniramine The risk or severity of QTc prolongation can be increased when Dexbrompheniramine is combined with Rilpivirine.
Meclizine	Meclizine The metabolism of Meclizine can be decreased when combined with Rilpivirine.
Hydrochlorothiazide	Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Rilpivirine.
Chlorzoxazone	Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Rilpivirine.
Folic Acid	Folic Acid Rilpivirine may decrease the excretion rate of Folic acid which could result in a higher serum level.
Disulfiram	Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Rilpivirine.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The metabolism of Rilpivirine can be decreased when combined with Propranolol.
Nortriptyline	Nortriptyline The metabolism of Rilpivirine can be decreased when combined with Nortriptyline.
Nadolol	Nadolol The metabolism of Nadolol can be decreased when combined with Rilpivirine.
Allopurinol	Allopurinol Rilpivirine may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Oxytocin Injection	Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Rilpivirine.
Papaverine	Papaverine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Papaverine.
Fluorouracil Injection	Fluorouracil Injection Rilpivirine may decrease the excretion rate of Fluorouracil which could result in a higher serum level.
Colchicine	Colchicine The metabolism of Colchicine can be decreased when combined with Rilpivirine.
Cephalexin	Cephalexin The metabolism of Cephalexin can be decreased when combined with Rilpivirine.
Bacillus Calmette-Guerin (BCG) Vaccine	Bacillus Calmette-Guerin (BCG) Vaccine The therapeutic efficacy of Bacillus calmette-guerin substrain tice live antigen can be decreased when used in combination with Rilpivirine.
Ketoconazole	Ketoconazole The serum concentration of Ketoconazole can be decreased when it is combined with Rilpivirine.
Thiotepa Injection	Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Rilpivirine.
Vincristine Injection	Vincristine Injection The metabolism of Vincristine can be decreased when combined with Rilpivirine.
Vinblastine	Vinblastine The metabolism of Vinblastine can be decreased when combined with Rilpivirine.
Metoprolol	Metoprolol The metabolism of Metoprolol can be decreased when combined with Rilpivirine.
Hydroxyzine	Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Rilpivirine.
Thiothixene	Thiothixene The risk or severity of QTc prolongation can be increased when Thiothixene is combined with Rilpivirine.
Alprazolam	Alprazolam The metabolism of Alprazolam can be decreased when combined with Rilpivirine.
Hyoscyamine	Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Rilpivirine.
Diltiazem	Diltiazem The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Diltiazem.
Nifedipine	Nifedipine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Nifedipine.
Timolol	Timolol The metabolism of Timolol can be decreased when combined with Rilpivirine.
Verapamil	Verapamil The metabolism of Verapamil can be decreased when combined with Rilpivirine.
Atenolol	Atenolol The metabolism of Atenolol can be decreased when combined with Rilpivirine.
Pindolol	Pindolol The metabolism of Pindolol can be decreased when combined with Rilpivirine.
Etoposide	Etoposide The metabolism of Etoposide can be decreased when combined with Rilpivirine.
Glyburide	Glyburide Rilpivirine may decrease the excretion rate of Glyburide which could result in a higher serum level.
Indapamide	Indapamide The risk or severity of QTc prolongation can be increased when Indapamide is combined with Rilpivirine.
Pentamidine Injection	Pentamidine Injection The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Pentamidine.
Labetalol	Labetalol The metabolism of Labetalol can be decreased when combined with Rilpivirine.
Leuprolide Injection	Leuprolide Injection The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Leuprolide.
Pimozide	Pimozide The metabolism of Pimozide can be decreased when combined with Rilpivirine.
Enalapril	Enalapril The excretion of Enalapril can be decreased when combined with Rilpivirine.
Amiodarone	Amiodarone The metabolism of Amiodarone can be decreased when combined with Rilpivirine.
Buspirone	Buspirone The metabolism of Buspirone can be decreased when combined with Rilpivirine.
Lovastatin	Lovastatin The metabolism of Lovastatin can be decreased when combined with Rilpivirine.
Ciprofloxacin	Ciprofloxacin The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Ciprofloxacin.
Diclofenac	Diclofenac The metabolism of Diclofenac can be decreased when combined with Rilpivirine.
Fluoxetine	Fluoxetine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Fluoxetine.
Nimodipine	Nimodipine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Nimodipine.
Clozapine	Clozapine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Clozapine.
Idarubicin	Idarubicin The metabolism of Idarubicin can be decreased when combined with Rilpivirine.
Ofloxacin	Ofloxacin The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Ofloxacin.
Clarithromycin	Clarithromycin The serum concentration of Rilpivirine can be increased when it is combined with Clarithromycin.
Felodipine	Felodipine The risk or severity of QTc prolongation can be increased when Felodipine is combined with Rilpivirine.
Pravastatin	Pravastatin Rilpivirine may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Simvastatin	Simvastatin The metabolism of Simvastatin can be decreased when combined with Rilpivirine.
Teniposide Injection	Teniposide Injection The metabolism of Teniposide can be decreased when combined with Rilpivirine.
Itraconazole	Itraconazole The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Rilpivirine.
Sotalol	Sotalol The metabolism of Sotalol can be decreased when combined with Rilpivirine.
Zolpidem	Zolpidem The metabolism of Zolpidem can be decreased when combined with Rilpivirine.
Doxazosin	Doxazosin The metabolism of Doxazosin can be decreased when combined with Rilpivirine.
Isradipine	Isradipine The risk or severity of QTc prolongation can be increased when Isradipine is combined with Rilpivirine.
Omeprazole	Omeprazole Omeprazole can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cisapride	Cisapride The metabolism of Cisapride can be decreased when combined with Rilpivirine.
Fluvastatin	Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Rilpivirine.
Venlafaxine	Venlafaxine The metabolism of Rilpivirine can be decreased when combined with Venlafaxine.
Nizatidine	Nizatidine Nizatidine can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Famciclovir	Famciclovir The metabolism of Famciclovir can be decreased when combined with Rilpivirine.
Fluvoxamine	Fluvoxamine The metabolism of Fluvoxamine can be decreased when combined with Rilpivirine.
Nefazodone	Nefazodone The metabolism of Nefazodone can be decreased when combined with Rilpivirine.
Lamotrigine	Lamotrigine The risk or severity of QTc prolongation can be increased when Lamotrigine is combined with Rilpivirine.
Losartan	Losartan The risk or severity of QTc prolongation can be increased when Losartan is combined with Rilpivirine.
Tramadol	Tramadol The metabolism of Rilpivirine can be decreased when combined with Tramadol.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Rilpivirine.
Moexipril	Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Rilpivirine.
Lansoprazole	Lansoprazole Lansoprazole can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Rilpivirine.
Nicardipine	Nicardipine The risk or severity of QTc prolongation can be increased when Nicardipine is combined with Rilpivirine.
Bupropion	Bupropion The serum concentration of Bupropion can be increased when it is combined with Rilpivirine.
Ticlopidine	Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Rilpivirine.
Saquinavir	Saquinavir The serum concentration of Rilpivirine can be increased when it is combined with Saquinavir.
Riluzole	Riluzole Rilpivirine may decrease the excretion rate of Riluzole which could result in a higher serum level.
Indinavir	Indinavir The serum concentration of Rilpivirine can be increased when it is combined with Indinavir.
Ritonavir	Ritonavir The serum concentration of Rilpivirine can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Rilpivirine.
Clomipramine	Clomipramine The metabolism of Clomipramine can be decreased when combined with Rilpivirine.
Zafirlukast	Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Rilpivirine.
Mirtazapine	Mirtazapine The risk or severity of QTc prolongation can be increased when Mirtazapine is combined with Rilpivirine.
Valsartan	Valsartan The excretion of Valsartan can be decreased when combined with Rilpivirine.
Donepezil	Donepezil The metabolism of Rilpivirine can be decreased when combined with Donepezil.
Nelfinavir	Nelfinavir The serum concentration of Rilpivirine can be increased when it is combined with Nelfinavir.
Fexofenadine	Fexofenadine The excretion of Fexofenadine can be decreased when combined with Rilpivirine.
Azithromycin	Azithromycin The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Azithromycin.
Carvedilol	Carvedilol The metabolism of Carvedilol can be decreased when combined with Rilpivirine.
Selegiline	Selegiline The metabolism of Selegiline can be decreased when combined with Rilpivirine.
Bicalutamide	Bicalutamide The metabolism of Bicalutamide can be decreased when combined with Rilpivirine.
Sertraline	Sertraline The metabolism of Sertraline can be decreased when combined with Rilpivirine.
Propafenone	Propafenone The metabolism of Propafenone can be decreased when combined with Rilpivirine.
Raloxifene	Raloxifene Rilpivirine may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Tamsulosin	Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Rilpivirine.
Quetiapine	Quetiapine The metabolism of Rilpivirine can be decreased when combined with Quetiapine.
Cetirizine	Cetirizine The risk or severity of QTc prolongation can be increased when Cetirizine is combined with Rilpivirine.
Paroxetine	Paroxetine The metabolism of Paroxetine can be decreased when combined with Rilpivirine.
Citalopram	Citalopram The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Citalopram.
Efavirenz	Efavirenz The metabolism of Efavirenz can be decreased when combined with Rilpivirine.
Sildenafil	Sildenafil The metabolism of Sildenafil can be decreased when combined with Rilpivirine.
Celecoxib	Celecoxib The metabolism of Rilpivirine can be decreased when combined with Celecoxib.
Tolterodine	Tolterodine The metabolism of Tolterodine can be decreased when combined with Rilpivirine.
Aluminum Hydroxide	Aluminum Hydroxide Aluminum hydroxide can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nateglinide	Nateglinide The metabolism of Nateglinide can be decreased when combined with Rilpivirine.
Galantamine	Galantamine The metabolism of Galantamine can be decreased when combined with Rilpivirine.
Rabeprazole	Rabeprazole Rabeprazole can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.