Sildenafil

Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Revatio) is used to improve the ability to exercise in adults with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Children should not usually take sildenafil, but in some cases, a doctor may decide that sildenafil (Revatio) is the best medication to treat a child's condition. Sildenafil is in a class of medications called phosphodiesterase (PDE) inhibitors. Sildenafil treats erectile dysfunction by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Sildenafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow easily.

If you are taking sildenafil to treat erectile dysfunction, you should know that it does not cure erectile dysfunction or increase sexual desire. Sildenafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV).

Sildenafil comes as a tablet and suspension (liquid; Revatio only) to take by mouth.

If you are taking sildenafil to treat erectile dysfunction, follow your doctor's directions and the guidelines in this paragraph. Take sildenafil as needed before sexual activity. The best time to take sildenafil is about 1 hour before sexual activity, but you can take the medication any time from 4 hours to 30 minutes before sexual activity. Sildenafil usually should not be taken more than once every 24 hours. If you have certain health conditions or are taking certain medications, your doctor may tell you to take sildenafil less often. You can take sildenafil with or without food. However, if you take sildenafil with a high-fat meal, it will take longer for the medication to start to work.

If you are taking sildenafil to treat PAH, follow your doctor's directions and the guidelines in this paragraph. You will probably take sildenafil three times a day with or without food. Take sildenafil at around the same times every day, and space your doses about 4 to 6 hours apart.

Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sildenafil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the liquid well for 10 seconds before each use to mix the medication evenly. Use the oral syringe provided with your medication to measure and take your dose. Follow the manufacturer's directions to use and clean the oral syringe. Do not mix the liquid with other medications or add anything to flavor the medication.

If you are taking sildenafil for erectile dysfunction, your doctor will probably start you on an average dose of sildenafil and increase or decrease your dose depending on your response to the medication. Tell your doctor if sildenafil is not working well or if you are experiencing side effects.

If you are taking sildenafil for PAH, you should know that sildenafil controls PAH but does not cure it. Continue to take sildenafil even if you feel well. Do not stop taking sildenafil without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking sildenafil,

• tell your doctor and pharmacist if you are allergic to sildenafil, any other medications, or any of the ingredients in sildenafil products. Ask your pharmacist for a list of the ingredients.

• do not take sildenafil if you are taking or have recently taken riociguat (Adempas) or nitrates (medications for chest pain) such as isosorbide dinitrate (Isordil), isosorbide mononitrate (Monoket), and nitroglycerin (Minitran, Nitro-Dur, Nitromist, Nitrostat, others). Nitrates come as tablets, sublingual (under the tongue) tablets, sprays, patches, pastes, and ointments. Ask your doctor if you are not sure whether any of your medications contain nitrates.

• do not take street drugs containing nitrates such as amyl nitrate and butyl nitrate ('poppers') while taking sildenafil.

• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: alpha blockers such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), tamsulosin (Flomax, in Jalyn), and terazosin; amlodipine (Norvasc, in Amturnide, in Tekamlo); certain antifungals such as itraconazole (Onmel, Sporanox) and ketoconazole (Nizoral); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); certain barbiturates such as butalbital (in Butapap, in Fioricet, in Fiorinal, others) and secobarbital (Seconal); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal LA, InnoPran); bosentan (Tracleer); cimetidine ; efavirenz (Sustiva, in Atripla); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors including amprenavir (Agenerase; no longer available in the U.S.), atazanavir (Reyataz, in Evotaz), darunavir (Prezista, in Prezcobix), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), saquinavir (Invirase), and tipranavir (Aptivus); nevirapine (Viramune); other medications or devices to treat erectile dysfunction; medications for high blood pressure; certain medications for seizures including carbamazepine (Carbatrol, Epitol, Tegretol, others), phenobarbital, and phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with sildenafil, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

• tell your doctor what herbal products you are taking or plan to take, especially St. John's wort.

• tell your doctor if you smoke, if you have ever had an erection that lasted for several hours, and if you have recently lost a large amount of body fluids (dehydration). This can happen if you are sick with fever, diarrhea, or vomiting; sweat a lot; or do not drink enough liquids. Also tell your doctor if you have or have ever had pulmonary veno-occlusive disease (PVOD; blockage of veins in the lungs); a stomach ulcer; heart, kidney, or liver disease; a heart attack; an irregular heartbeat; a stroke; chest pain; high or low blood pressure; high cholesterol; a bleeding disorder; blood circulation problems;blood cell problems such as sickle cell anemia (a disease of the red blood cells), multiple myeloma (cancer of the plasma cells), or leukemia (cancer of the white blood cells); conditions affecting the shape of the penis (e.g., angulation, cavernosal fibrosis, or Peyronie's disease); or diabetes. Also tell your doctor if you or any of your family members have or have ever had an eye disease such as retinitis pigmentosa (an inherited eye condition that causes loss of vision) or if you have ever had sudden severe vision loss, especially if you were told that the vision loss was caused by a blockage of blood flow to the nerves that help you see.

• if you are a woman and you are taking sildenafil to treat PAH, tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking sildenafil, call your doctor.

• if you are having surgery, including dental surgery, tell your doctor or dentist that you are taking sildenafil.

• if you are taking sildenafil to treat erectile dysfunction, tell your doctor if you have ever been advised by a healthcare professional to avoid sexual activity for medical reasons or if you have ever experienced chest pain during sexual activity. Sexual activity may be a strain on your heart, especially if you have heart disease. If you experience chest pain, dizziness, or nausea during sexual activity, call your doctor immediately and avoid sexual activity until your doctor tells you otherwise.

• tell all your healthcare providers that you are taking sildenafil. If you ever need emergency medical treatment for a heart problem, the healthcare providers who treat you will need to know when you last took sildenafil.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

If you are taking sildenafil for erectile dysfunction, you are unlikely to miss a dose since this medication is taken as needed, not on a regular dosing schedule.

If you are taking sildenafil for PAH, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Sildenafil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache

  • heartburn

  • diarrhea

  • flushing (feeling of warmth)

  • nosebleeds

  • difficulty falling asleep or staying asleep

  • numbness, burning, or tingling in the arms, hands, feet, or legs

  • muscle aches

  • changes in color vision (seeing a blue tinge on objects or having difficulty telling the difference between blue and green)

  • sensitivity to light

• Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

  • sudden severe loss of vision (see below for more information)

  • blurred vision

  • sudden decrease or loss of hearing

  • ringing in ears

  • dizziness or lightheadedness

  • fainting

  • chest pain

  • worsening shortness of breath

  • erection that is painful or lasts longer than 4 hours

  • itching or burning during urination

  • rash

• Some patients experienced a sudden loss of some or all of their vision after they took sildenafil or other medications that are similar to sildenafil. The vision loss was permanent in some cases. It is not known if the vision loss was caused by the medication. If you experience a sudden loss of vision while you are taking sildenafil, call your doctor immediately. Do not take any more doses of sildenafil or similar medications such as tadalafil (Cialis) or vardenafil (Levitra) until you talk to your doctor.

• There have been reports of heart attack, stroke, irregular heartbeat, bleeding in the brain or lungs, high blood pressure, and sudden death in men who took sildenafil for erectile dysfunction. Most, but not all, of these people had heart problems before taking sildenafil. It is not known whether these events were caused by sildenafil, sexual activity, heart disease, or a combination of these and other causes.Talk to your doctor about the risks of taking sildenafil.

• Some patients experienced a sudden decrease or loss of hearing after they took sildenafil or other medications that are similar to sildenafil. The hearing loss usually involved only one ear and did not always improve when the medication was stopped. It is not known if the hearing loss was caused by the medication. If you experience a sudden loss of hearing, sometimes with ringing in the ears or dizziness, while you are taking sildenafil, call your doctor immediately. If you are taking sildenafil (Viagra) for erectile dysfunction, do not take any more doses of sildenafil (Viagra) or similar medications such as tadalafil (Cialis) or vardenafil (Levitra) until you talk to your doctor. If you are taking sildenafil (Revatio) for PAH, do not stop taking your medication until you talk to your doctor.

• Sildenafil may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the tablets at room temperature and away from excess heat and moisture (not in the bathroom). Store the suspension at room temperature or in a refrigerator, but do not freeze it. Dispose of any unused suspension after 60 days.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Repaglinide	Repaglinide The excretion of Repaglinide can be decreased when combined with Sildenafil.
Montelukast	Montelukast The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Montelukast.
Leflunomide	Leflunomide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Leflunomide.
Delavirdine	Delavirdine The metabolism of Sildenafil can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Sildenafil can be decreased when combined with Nevirapine.
Atorvastatin	Atorvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Atorvastatin.
Dolasetron	Dolasetron The metabolism of Dolasetron can be decreased when combined with Sildenafil.
Alendronate	Alendronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Alendronic acid.
Aminophylline	Aminophylline The metabolism of Aminophylline can be decreased when combined with Sildenafil.
Candesartan	Candesartan Sildenafil may increase the antihypertensive activities of Candesartan.
Cilostazol	Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Sildenafil.
Clopidogrel	Clopidogrel The metabolism of Sildenafil can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The metabolism of Sildenafil can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) The excretion of Conjugated estrogens can be decreased when combined with Sildenafil.
Fenofibrate	Fenofibrate The metabolism of Sildenafil can be decreased when combined with Fenofibrate.
Guanfacine	Guanfacine Sildenafil may increase the antihypertensive activities of Guanfacine.
Nafarelin	Nafarelin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Nafarelin.
Paregoric	Paregoric The serum concentration of Sildenafil can be increased when it is combined with Morphine.
Penbutolol	Penbutolol The metabolism of Acebutolol can be decreased when combined with Sildenafil.
Ranitidine	Ranitidine The metabolism of Sildenafil can be decreased when combined with Ranitidine.
Reserpine	Reserpine The serum concentration of Reserpine can be increased when it is combined with Sildenafil.
Sumatriptan	Sumatriptan The excretion of Sumatriptan can be decreased when combined with Sildenafil.
Tacrolimus	Tacrolimus The metabolism of Sildenafil can be decreased when combined with Tacrolimus.
Tizanidine	Tizanidine The risk or severity of hypotension can be increased when Sildenafil is combined with Tizanidine.
Triamcinolone	Triamcinolone The metabolism of Sildenafil can be increased when combined with Triamcinolone.
Fluconazole Injection	Fluconazole Injection The serum concentration of Sildenafil can be increased when it is combined with Fluconazole.
Hydromorphone Injection	Hydromorphone Injection The metabolism of Hydromorphone can be decreased when combined with Sildenafil.
Meperidine Injection	Meperidine Injection The metabolism of Meperidine can be decreased when combined with Sildenafil.
Metoclopramide Injection	Metoclopramide Injection The metabolism of Sildenafil can be decreased when combined with Metoclopramide.
Metronidazole Injection	Metronidazole Injection The metabolism of Sildenafil can be decreased when combined with Metronidazole.
Morphine Injection	Morphine Injection The serum concentration of Sildenafil can be increased when it is combined with Morphine.
Pamidronate Injection	Pamidronate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Pamidronic acid.
Zidovudine Injection	Zidovudine Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Zidovudine.
Altretamine	Altretamine The metabolism of Sildenafil can be decreased when combined with Amphetamine.
Cyclosporine	Cyclosporine The metabolism of Sildenafil can be decreased when combined with Cyclosporine.
Ondansetron	Ondansetron The metabolism of Ondansetron can be decreased when combined with Sildenafil.
Enoxaparin Injection	Enoxaparin Injection The risk or severity of hemorrhage can be increased when Enoxaparin is combined with Sildenafil.
Torsemide	Torsemide The metabolism of Torasemide can be decreased when combined with Sildenafil.
Olanzapine	Olanzapine The risk or severity of hypotension, dyspepsia, and headache can be increased when Olanzapine is combined with Sildenafil.
Alosetron	Alosetron The metabolism of Alosetron can be decreased when combined with Sildenafil.
Entacapone	Entacapone The metabolism of Sildenafil can be decreased when combined with Entacapone.
Eprosartan	Eprosartan The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Eprosartan.
Hydroxychloroquine	Hydroxychloroquine The metabolism of Sildenafil can be decreased when combined with Hydroxychloroquine.
Meloxicam	Meloxicam The metabolism of Meloxicam can be decreased when combined with Sildenafil.
Oxcarbazepine	Oxcarbazepine The metabolism of Sildenafil can be increased when combined with Oxcarbazepine.
Pantoprazole	Pantoprazole The metabolism of Pantoprazole can be decreased when combined with Sildenafil.
Risedronate	Risedronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Risedronic acid.
Telmisartan	Telmisartan Sildenafil may increase the antihypertensive activities of Telmisartan.
Zaleplon	Zaleplon The metabolism of Zaleplon can be decreased when combined with Sildenafil.
Anakinra	Anakinra The metabolism of Sildenafil can be increased when combined with Anakinra.
Pentosan Polysulfate	Pentosan Polysulfate The risk or severity of hemorrhage can be increased when Pentosan polysulfate is combined with Sildenafil.
Trimipramine	Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Sildenafil.
Etanercept Injection	Etanercept Injection The metabolism of Sildenafil can be increased when combined with Etanercept.
Modafinil	Modafinil The metabolism of Sildenafil can be increased when combined with Modafinil.
Perindopril	Perindopril Sildenafil may increase the antihypertensive activities of Perindopril.
Tenofovir	Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Sildenafil.
Sirolimus	Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Sildenafil.
Dutasteride	Dutasteride The metabolism of Dutasteride can be decreased when combined with Sildenafil.
Epinephrine Injection	Epinephrine Injection The metabolism of Sildenafil can be decreased when combined with Epinephrine.
Eplerenone	Eplerenone Sildenafil may increase the antihypertensive activities of Eplerenone.
Escitalopram	Escitalopram The serum concentration of Sildenafil can be increased when it is combined with Escitalopram.
Olmesartan	Olmesartan Sildenafil may increase the antihypertensive activities of Olmesartan.
Zonisamide	Zonisamide The metabolism of Sildenafil can be decreased when combined with Zonisamide.
Adalimumab Injection	Adalimumab Injection The metabolism of Sildenafil can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The risk or severity of hypotension, dyspepsia, and headache can be increased when Sildenafil is combined with Aripiprazole.
Atomoxetine	Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Sildenafil.
Ezetimibe	Ezetimibe The excretion of Ezetimibe can be decreased when combined with Sildenafil.
Atazanavir	Atazanavir The metabolism of Sildenafil can be decreased when combined with Atazanavir.
Almotriptan	Almotriptan The metabolism of Almotriptan can be decreased when combined with Sildenafil.
Eletriptan	Eletriptan The metabolism of Eletriptan can be decreased when combined with Sildenafil.
Mefloquine	Mefloquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Mefloquine is combined with Sildenafil.
Rosuvastatin	Rosuvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Rosuvastatin.
Vardenafil	Vardenafil The risk or severity of adverse effects can be increased when Sildenafil is combined with Vardenafil.
Alfuzosin	Alfuzosin The risk or severity of hypotension, dyspepsia, and headache can be increased when Sildenafil is combined with Alfuzosin.
Aprepitant	Aprepitant The metabolism of Sildenafil can be decreased when combined with Aprepitant.
Tegaserod	Tegaserod The metabolism of Sildenafil can be decreased when combined with Tegaserod.
Tadalafil	Tadalafil The risk or severity of adverse effects can be increased when Sildenafil is combined with Tadalafil.
Progesterone	Progesterone The metabolism of Sildenafil can be decreased when combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Sildenafil.
Infliximab Injection	Infliximab Injection The metabolism of Sildenafil can be increased when combined with Infliximab.
Oxandrolone	Oxandrolone The metabolism of Sildenafil can be decreased when combined with Oxandrolone.
Protriptyline	Protriptyline The metabolism of Protriptyline can be decreased when combined with Sildenafil.
Rifaximin	Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Sildenafil.
Duloxetine	Duloxetine The metabolism of Sildenafil can be decreased when combined with Duloxetine.
Norethindrone	Norethindrone The metabolism of Norethisterone can be decreased when combined with Sildenafil.
Trospium	Trospium The metabolism of Sildenafil can be decreased when combined with Trospium.
Bosentan	Bosentan The metabolism of Sildenafil can be increased when combined with Bosentan.
Cinacalcet	Cinacalcet The metabolism of Sildenafil can be decreased when combined with Cinacalcet.
Erlotinib	Erlotinib The metabolism of Erlotinib can be decreased when combined with Sildenafil.
Ganciclovir	Ganciclovir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Ganciclovir.
Solifenacin	Solifenacin The metabolism of Solifenacin can be decreased when combined with Sildenafil.
Voriconazole	Voriconazole The serum concentration of Sildenafil can be increased when it is combined with Voriconazole.
Dextroamphetamine	Dextroamphetamine The metabolism of Sildenafil can be decreased when combined with Amphetamine.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The metabolism of Sildenafil can be increased when combined with Peginterferon alfa-2b.
Ibandronate	Ibandronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Ibandronate.
Isocarboxazid	Isocarboxazid The risk or severity of hypotension can be increased when Sildenafil is combined with Isocarboxazid.
Ramelteon	Ramelteon The metabolism of Ramelteon can be decreased when combined with Sildenafil.
Darifenacin	Darifenacin The metabolism of Darifenacin can be decreased when combined with Sildenafil.
Fentanyl	Fentanyl The metabolism of Fentanyl can be decreased when combined with Sildenafil.
Phenylephrine	Phenylephrine The risk or severity of hypertension can be decreased when Sildenafil is combined with Phenylephrine.
Tipranavir	Tipranavir The metabolism of Tipranavir can be decreased when combined with Sildenafil.
Felbamate	Felbamate The metabolism of Sildenafil can be decreased when combined with Felbamate.
Ranolazine	Ranolazine The serum concentration of Sildenafil can be increased when it is combined with Ranolazine.
Abatacept Injection	Abatacept Injection The metabolism of Sildenafil can be increased when combined with Abatacept.
Rasagiline	Rasagiline The risk or severity of hypotension can be increased when Sildenafil is combined with Rasagiline.
Imatinib	Imatinib The metabolism of Sildenafil can be decreased when combined with Imatinib.
Sitagliptin	Sitagliptin The serum concentration of Sildenafil can be increased when it is combined with Sitagliptin.
Gefitinib	Gefitinib The metabolism of Sildenafil can be decreased when combined with Gefitinib.
Paliperidone	Paliperidone The serum concentration of Sildenafil can be increased when it is combined with Paliperidone.
Bortezomib	Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Sildenafil.
Clofarabine Injection	Clofarabine Injection The risk or severity of hypotension can be increased when Sildenafil is combined with Clofarabine.
Posaconazole	Posaconazole The serum concentration of Sildenafil can be increased when it is combined with Posaconazole.
Primaquine	Primaquine The metabolism of Sildenafil can be decreased when combined with Primaquine.
Aliskiren	Aliskiren Sildenafil may increase the antihypertensive activities of Aliskiren.
Darunavir	Darunavir The risk or severity of adverse effects can be increased when Sildenafil is combined with Darunavir.
Lisdexamfetamine	Lisdexamfetamine The metabolism of Sildenafil can be decreased when combined with Lisdexamfetamine.
Nabilone	Nabilone The metabolism of Sildenafil can be decreased when combined with Nabilone.
Sorafenib	Sorafenib The metabolism of Sorafenib can be decreased when combined with Sildenafil.
Sunitinib	Sunitinib The metabolism of Sunitinib can be decreased when combined with Sildenafil.
Dronabinol	Dronabinol The metabolism of Dronabinol can be decreased when combined with Sildenafil.
Lapatinib	Lapatinib The serum concentration of Lapatinib can be increased when it is combined with Sildenafil.
Dasatinib	Dasatinib The serum concentration of Dasatinib can be increased when it is combined with Sildenafil.
Mexiletine	Mexiletine The metabolism of Mexiletine can be decreased when combined with Sildenafil.
Armodafinil	Armodafinil The metabolism of Sildenafil can be increased when combined with Armodafinil.
Ivermectin	Ivermectin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Ivermectin.
Temsirolimus	Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Sildenafil.
Nilotinib	Nilotinib The metabolism of Sildenafil can be decreased when combined with Nilotinib.
Toremifene	Toremifene The serum concentration of Sildenafil can be increased when it is combined with Toremifene.
Raltegravir	Raltegravir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Raltegravir.
Bexarotene	Bexarotene The metabolism of Bexarotene can be decreased when combined with Sildenafil.
Budesonide	Budesonide The metabolism of Sildenafil can be increased when combined with Budesonide.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Sildenafil can be decreased when combined with Chloramphenicol.
Etravirine	Etravirine The metabolism of Sildenafil can be decreased when combined with Etravirine.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of hypotension can be increased when Sildenafil is combined with Arsenic trioxide.
Sapropterin	Sapropterin Sapropterin may increase the hypotensive activities of Sildenafil.
Desvenlafaxine	Desvenlafaxine The metabolism of Sildenafil can be decreased when combined with Desvenlafaxine.
Cevimeline	Cevimeline The metabolism of Sildenafil can be decreased when combined with Cevimeline.
Nebivolol	Nebivolol The metabolism of Nebivolol can be decreased when combined with Sildenafil.
Tretinoin	Tretinoin The metabolism of Tretinoin can be decreased when combined with Sildenafil.
Bendamustine Injection	Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Sildenafil.
Flecainide	Flecainide The metabolism of Flecainide can be decreased when combined with Sildenafil.
Certolizumab Injection	Certolizumab Injection The metabolism of Sildenafil can be increased when combined with Certolizumab pegol.
Irinotecan Injection	Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Sildenafil.
Daptomycin Injection	Daptomycin Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Sildenafil.
Praziquantel	Praziquantel The metabolism of Praziquantel can be decreased when combined with Sildenafil.
Silodosin	Silodosin The serum concentration of Silodosin can be increased when it is combined with Sildenafil.
Midazolam	Midazolam The metabolism of Midazolam can be decreased when combined with Sildenafil.
Naltrexone Injection	Naltrexone Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Naltrexone.
Dexlansoprazole	Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Sildenafil.
Fesoterodine	Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Sildenafil.
Betaxolol	Betaxolol Sildenafil may increase the antihypertensive activities of Betaxolol.
Iloperidone	Iloperidone The risk or severity of hypotension, dyspepsia, and headache can be increased when Sildenafil is combined with Iloperidone.
Prasugrel	Prasugrel The risk or severity of hemorrhage can be increased when Prasugrel is combined with Sildenafil.
Lacosamide	Lacosamide The metabolism of Lacosamide can be decreased when combined with Sildenafil.
Everolimus	Everolimus The serum concentration of Everolimus can be increased when it is combined with Sildenafil.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Sildenafil.
Dronedarone	Dronedarone The metabolism of Sildenafil can be decreased when combined with Dronedarone.
Palonosetron Injection	Palonosetron Injection The metabolism of Palonosetron can be decreased when combined with Sildenafil.
Saxagliptin	Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Sildenafil.
Romidepsin Injection	Romidepsin Injection The serum concentration of Sildenafil can be increased when it is combined with Romidepsin.
Tapentadol	Tapentadol The metabolism of Sildenafil can be decreased when combined with Tapentadol.
Topotecan	Topotecan The serum concentration of Topotecan can be increased when it is combined with Sildenafil.
Golimumab Injection	Golimumab Injection The metabolism of Sildenafil can be increased when combined with Golimumab.
Pazopanib	Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Sildenafil.
Asenapine	Asenapine The risk or severity of hypotension, dyspepsia, and headache can be increased when Sildenafil is combined with Asenapine.
Pitavastatin	Pitavastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Pitavastatin.
Albendazole	Albendazole The metabolism of Albendazole can be decreased when combined with Sildenafil.
Levonorgestrel	Levonorgestrel The metabolism of Levonorgestrel can be decreased when combined with Sildenafil.
Oxymorphone	Oxymorphone The metabolism of Oxymorphone can be decreased when combined with Sildenafil.
Dabigatran	Dabigatran The risk or severity of hemorrhage can be increased when Dabigatran is combined with Sildenafil.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Sildenafil can be increased when combined with Tocilizumab.
Fingolimod	Fingolimod The metabolism of Fingolimod can be decreased when combined with Sildenafil.
Cabazitaxel Injection	Cabazitaxel Injection The serum concentration of Sildenafil can be increased when it is combined with Cabazitaxel.
Acetaminophen Injection	Acetaminophen Injection Sildenafil may increase the hepatotoxic activities of Acetaminophen.
Vilazodone	Vilazodone The metabolism of Sildenafil can be decreased when combined with Vilazodone.
Denileukin Diftitox Injection	Denileukin Diftitox Injection The risk or severity of hypotension can be increased when Sildenafil is combined with Aldesleukin.
Azilsartan	Azilsartan The risk or severity of hypotension can be increased when Sildenafil is combined with Azilsartan medoxomil.
Linagliptin	Linagliptin The serum concentration of Linagliptin can be increased when it is combined with Sildenafil.
Rilpivirine	Rilpivirine The metabolism of Sildenafil can be decreased when combined with Rilpivirine.
Telaprevir	Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Sildenafil.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Sildenafil.
Abiraterone	Abiraterone The metabolism of Sildenafil can be decreased when combined with Abiraterone.
Rivaroxaban	Rivaroxaban The risk or severity of hemorrhage can be increased when Rivaroxaban is combined with Sildenafil.
Ticagrelor	Ticagrelor The risk or severity of hemorrhage can be increased when Ticagrelor is combined with Sildenafil.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Sildenafil.
Vandetanib	Vandetanib The serum concentration of Sildenafil can be increased when it is combined with Vandetanib.
Clobazam	Clobazam The metabolism of Sildenafil can be decreased when combined with Clobazam.
Vemurafenib	Vemurafenib The serum concentration of Sildenafil can be increased when it is combined with Vemurafenib.
Vismodegib	Vismodegib The metabolism of Sildenafil can be decreased when combined with Vismodegib.
Ivacaftor	Ivacaftor The serum concentration of Ivacaftor can be increased when it is combined with Sildenafil.
Axitinib	Axitinib The serum concentration of Axitinib can be increased when it is combined with Sildenafil.
Crizotinib	Crizotinib The serum concentration of Sildenafil can be increased when it is combined with Crizotinib.
Cabergoline	Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Sildenafil.
Naloxone Injection	Naloxone Injection The metabolism of Sildenafil can be decreased when combined with Naloxone.
Ambrisentan	Ambrisentan The serum concentration of Sildenafil can be increased when it is combined with Ambrisentan.
Fondaparinux Injection	Fondaparinux Injection The risk or severity of hemorrhage can be increased when Fondaparinux is combined with Sildenafil.
Carfilzomib Injection	Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Sildenafil.
Iloprost	Iloprost The risk or severity of hemorrhage can be increased when Iloprost is combined with Sildenafil.
Enzalutamide	Enzalutamide The serum concentration of Enzalutamide can be increased when it is combined with Sildenafil.
Mirabegron	Mirabegron The metabolism of Mirabegron can be decreased when combined with Sildenafil.
Regorafenib	Regorafenib The serum concentration of Regorafenib can be increased when it is combined with Sildenafil.
Bosutinib	Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Sildenafil.
Cabozantinib (thyroid cancer)	Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Sildenafil.
Alogliptin	Alogliptin The metabolism of Alogliptin can be decreased when combined with Sildenafil.
Ponatinib	Ponatinib The metabolism of Sildenafil can be decreased when combined with Ponatinib.
Pomalidomide	Pomalidomide The serum concentration of Sildenafil can be increased when it is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Sildenafil.
Apixaban	Apixaban The risk or severity of hemorrhage can be increased when Apixaban is combined with Sildenafil.
Canagliflozin	Canagliflozin The serum concentration of Sildenafil can be increased when it is combined with Canagliflozin.
Methazolamide	Methazolamide The risk or severity of hypotension can be increased when Sildenafil is combined with Methazolamide.
Dabrafenib	Dabrafenib The serum concentration of Sildenafil can be increased when it is combined with Dabrafenib.
Ospemifene	Ospemifene The metabolism of Ospemifene can be decreased when combined with Sildenafil.
Dolutegravir	Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Sildenafil.
Afatinib	Afatinib The serum concentration of Afatinib can be increased when it is combined with Sildenafil.
Levomilnacipran	Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Sildenafil.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Sildenafil.
Perampanel	Perampanel The metabolism of Perampanel can be decreased when combined with Sildenafil.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Sildenafil.
Lomitapide	Lomitapide The serum concentration of Sildenafil can be increased when it is combined with Lomitapide.
Avanafil	Avanafil The risk or severity of adverse effects can be increased when Sildenafil is combined with Avanafil.
Ketorolac Injection	Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Sildenafil.
Obinutuzumab Injection	Obinutuzumab Injection The risk or severity of hypotension can be increased when Sildenafil is combined with Obinutuzumab.
Simeprevir	Simeprevir The serum concentration of Simeprevir can be increased when it is combined with Sildenafil.
Sofosbuvir	Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Sildenafil.
Dapagliflozin	Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Sildenafil.
Apremilast	Apremilast The metabolism of Sildenafil can be increased when combined with Apremilast.
Ceritinib	Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Sildenafil.
Siltuximab Injection	Siltuximab Injection The metabolism of Sildenafil can be increased when combined with Siltuximab.
Belinostat Injection	Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Sildenafil.
Idelalisib	Idelalisib The serum concentration of Idelalisib can be increased when it is combined with Sildenafil.
Testosterone Injection	Testosterone Injection The metabolism of Testosterone can be decreased when combined with Sildenafil.
Oritavancin Injection	Oritavancin Injection The metabolism of Sildenafil can be decreased when combined with Oritavancin.
Empagliflozin	Empagliflozin The risk or severity of hypotension can be increased when Sildenafil is combined with Empagliflozin.
Vorapaxar	Vorapaxar The risk or severity of hemorrhage can be increased when Vorapaxar is combined with Sildenafil.
Suvorexant	Suvorexant The serum concentration of Sildenafil can be increased when it is combined with Suvorexant.
Edoxaban	Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Sildenafil.
Olaparib	Olaparib The metabolism of Olaparib can be decreased when combined with Sildenafil.
Caspofungin Injection	Caspofungin Injection The excretion of Caspofungin can be decreased when combined with Sildenafil.
Methamphetamine	Methamphetamine The metabolism of Metamfetamine can be decreased when combined with Sildenafil.
Riociguat	Riociguat The risk or severity of hypotension can be increased when Sildenafil is combined with Riociguat.
Nintedanib	Nintedanib The serum concentration of Nintedanib can be increased when it is combined with Sildenafil.
Secukinumab Injection	Secukinumab Injection The metabolism of Sildenafil can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The risk or severity of hypotension, dyspepsia, and headache can be increased when Sildenafil is combined with Risperidone.
Palbociclib	Palbociclib The serum concentration of Palbociclib can be increased when it is combined with Sildenafil.
Lenvatinib	Lenvatinib The serum concentration of Lenvatinib can be increased when it is combined with Sildenafil.
Naloxegol	Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Sildenafil.
Panobinostat	Panobinostat The metabolism of Sildenafil can be decreased when combined with Panobinostat.
Dinutuximab Injection	Dinutuximab Injection The risk or severity of hypotension can be increased when Sildenafil is combined with Dinutuximab.
Haloperidol Injection	Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Sildenafil.
Amiloride	Amiloride The risk or severity of hypotension can be increased when Sildenafil is combined with Amiloride.
Isavuconazonium Injection	Isavuconazonium Injection The serum concentration of Sildenafil can be increased when it is combined with Isavuconazonium.
Macitentan	Macitentan Sildenafil may increase the antihypertensive activities of Macitentan.
Flibanserin	Flibanserin The serum concentration of Sildenafil can be increased when it is combined with Flibanserin.
Rolapitant	Rolapitant The metabolism of Sildenafil can be decreased when combined with Rolapitant.
Daclatasvir	Daclatasvir The serum concentration of Sildenafil can be increased when it is combined with Daclatasvir.
Brexpiprazole	Brexpiprazole The risk or severity of hypotension, dyspepsia, and headache can be increased when Sildenafil is combined with Brexpiprazole.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of hypotension, dyspepsia, and headache can be increased when Sildenafil is combined with Ziprasidone.
Cariprazine	Cariprazine The metabolism of Cariprazine can be decreased when combined with Sildenafil.
Eluxadoline	Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Sildenafil.
Cobimetinib	Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Sildenafil.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Sildenafil.
Osimertinib	Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Sildenafil.
Lesinurad	Lesinurad The metabolism of Lesinurad can be decreased when combined with Sildenafil.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Amphotericin B.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Sildenafil can be increased when combined with Dexamethasone.
Defibrotide Injection	Defibrotide Injection The risk or severity of hemorrhage can be increased when Defibrotide is combined with Sildenafil.
Brivaracetam Injection	Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Sildenafil.
Venetoclax	Venetoclax The serum concentration of Venetoclax can be increased when it is combined with Sildenafil.
Cobicistat	Cobicistat The metabolism of Sildenafil can be decreased when combined with Cobicistat.
Selexipag	Selexipag The serum concentration of Sildenafil can be increased when it is combined with Selexipag.
Diphenhydramine Injection	Diphenhydramine Injection The metabolism of Sildenafil can be decreased when combined with Diphenhydramine.
Furosemide Injection	Furosemide Injection Sildenafil may increase the antihypertensive activities of Furosemide.
Rucaparib	Rucaparib The metabolism of Sildenafil can be decreased when combined with Rucaparib.
Ribociclib	Ribociclib The metabolism of Sildenafil can be decreased when combined with Ribociclib.
Doxepin (Insomnia)	Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Sildenafil.
Deutetrabenazine	Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Sildenafil.
Valbenazine	Valbenazine The metabolism of Valbenazine can be decreased when combined with Sildenafil.
Deflazacort	Deflazacort The metabolism of Sildenafil can be increased when combined with Deflazacort.
Safinamide	Safinamide The metabolism of Sildenafil can be decreased when combined with Safinamide.
Midostaurin	Midostaurin The metabolism of Sildenafil can be decreased when combined with Midostaurin.
Neratinib	Neratinib The serum concentration of Sildenafil can be increased when it is combined with Neratinib.
Enasidenib	Enasidenib The metabolism of Sildenafil can be decreased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection	Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Sildenafil.
Copanlisib Injection	Copanlisib Injection The serum concentration of Sildenafil can be increased when it is combined with Copanlisib.
Delafloxacin	Delafloxacin The metabolism of Sildenafil can be increased when combined with Delafloxacin.
Abemaciclib	Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Sildenafil.
Betrixaban	Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Sildenafil.
Acalabrutinib	Acalabrutinib The metabolism of Sildenafil can be decreased when combined with Acalabrutinib.
Letermovir	Letermovir The metabolism of Sildenafil can be decreased when combined with Letermovir.
Tetrabenazine	Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Sildenafil.
Ertugliflozin	Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Sildenafil.
Buprenorphine Injection	Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Sildenafil.
Apalutamide	Apalutamide The serum concentration of Sildenafil can be decreased when it is combined with Apalutamide.
Penicillamine	Penicillamine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Penicillamine.
Fostamatinib	Fostamatinib The risk or severity of adverse effects can be increased when Sildenafil is combined with Fostamatinib.
Avatrombopag	Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Sildenafil.
Baricitinib	Baricitinib The serum concentration of Sildenafil can be increased when it is combined with Baricitinib.
Lofexidine	Lofexidine Sildenafil may increase the antihypertensive activities of Lofexidine.
Eliglustat	Eliglustat The metabolism of Sildenafil can be decreased when combined with Eliglustat.
Encorafenib	Encorafenib The metabolism of Encorafenib can be decreased when combined with Sildenafil.
Binimetinib	Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Sildenafil.
Ivosidenib	Ivosidenib The serum concentration of Ivosidenib can be increased when it is combined with Sildenafil.
Lusutrombopag	Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Sildenafil.
Elagolix	Elagolix The serum concentration of Elagolix can be increased when it is combined with Sildenafil.
Doravirine	Doravirine The metabolism of Doravirine can be decreased when combined with Sildenafil.
Tafenoquine	Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Sildenafil.
Cannabidiol	Cannabidiol The metabolism of Sildenafil can be decreased when combined with Cannabidiol.
Dacomitinib	Dacomitinib The serum concentration of Sildenafil can be increased when it is combined with Dacomitinib.
Duvelisib	Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Sildenafil.
Omadacycline	Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Sildenafil.
Sarecycline	Sarecycline The serum concentration of Sildenafil can be increased when it is combined with Sarecycline.
Stiripentol	Stiripentol The metabolism of Sildenafil can be decreased when combined with Stiripentol.
Talazoparib	Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Sildenafil.
Gilteritinib	Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Sildenafil.
Glasdegib	Glasdegib The serum concentration of Sildenafil can be increased when it is combined with Glasdegib.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Sildenafil.
Larotrectinib	Larotrectinib The serum concentration of Sildenafil can be increased when it is combined with Larotrectinib.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Sildenafil.
Rifamycin	Rifamycin The serum concentration of Rifamycin can be increased when it is combined with Sildenafil.
Prucalopride	Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Sildenafil.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Sildenafil can be increased when combined with Emapalumab.
Siponimod	Siponimod The metabolism of Siponimod can be decreased when combined with Sildenafil.
Erdafitinib	Erdafitinib The serum concentration of Sildenafil can be increased when it is combined with Erdafitinib.
Esomeprazole Injection	Esomeprazole Injection The metabolism of Esomeprazole can be decreased when combined with Sildenafil.
Alpelisib	Alpelisib The serum concentration of Sildenafil can be decreased when it is combined with Alpelisib.
Cladribine	Cladribine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Cladribine.
Darolutamide	Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Sildenafil.
Triclabendazole	Triclabendazole The metabolism of Sildenafil can be decreased when combined with Triclabendazole.
Entrectinib	Entrectinib The serum concentration of Sildenafil can be increased when it is combined with Entrectinib.
Istradefylline	Istradefylline The serum concentration of Istradefylline can be increased when it is combined with Sildenafil.
Pitolisant	Pitolisant The serum concentration of Sildenafil can be decreased when it is combined with Pitolisant.
Fedratinib	Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Sildenafil.
Lefamulin	Lefamulin Sildenafil may decrease the excretion rate of Lefamulin which could result in a higher serum level.
Phenytoin Injection	Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Sildenafil.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Sildenafil can be decreased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection	Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Sildenafil.
Voxelotor	Voxelotor The metabolism of Voxelotor can be decreased when combined with Sildenafil.
Avapritinib	Avapritinib The metabolism of Avapritinib can be decreased when combined with Sildenafil.
Lasmiditan	Lasmiditan The serum concentration of Sildenafil can be increased when it is combined with Lasmiditan.
Ubrogepant	Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Sildenafil.
Tazemetostat	Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Sildenafil.
Cenobamate	Cenobamate The serum concentration of Sildenafil can be decreased when it is combined with Cenobamate.
Selumetinib	Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Sildenafil.
Rimegepant	Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Sildenafil.
Tucatinib	Tucatinib Sildenafil may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection	Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Sildenafil.
Ripretinib	Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Sildenafil.
Lemborexant	Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Sildenafil.
Fenfluramine	Fenfluramine The metabolism of Sildenafil can be decreased when combined with Fenfluramine.
Fostemsavir	Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Sildenafil.
Belantamab Mafodotin-blmf Injection	Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Sildenafil.
Pralsetinib	Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Sildenafil.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Sildenafil can be decreased when it is combined with Satralizumab.
Relugolix	Relugolix The serum concentration of Relugolix can be increased when it is combined with Sildenafil.
Indomethacin	Indomethacin The metabolism of Indomethacin can be decreased when combined with Sildenafil.
Mefenamic Acid	Mefenamic Acid The metabolism of Mefenamic acid can be decreased when combined with Sildenafil.
Naproxen	Naproxen The metabolism of Naproxen can be decreased when combined with Sildenafil.
Trazodone	Trazodone The metabolism of Trazodone can be decreased when combined with Sildenafil.
Isotretinoin	Isotretinoin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Isotretinoin.
Hydroxyurea	Hydroxyurea The metabolism of Sildenafil can be decreased when combined with Hydroxyurea.
Floxuridine	Floxuridine The metabolism of Sildenafil can be decreased when combined with Floxuridine.
Phenobarbital	Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Sildenafil.
Methotrexate Injection	Methotrexate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Methotrexate.
Primidone	Primidone The metabolism of Primidone can be decreased when combined with Sildenafil.
Methsuximide	Methsuximide The metabolism of Methsuximide can be decreased when combined with Sildenafil.
Chlorpromazine	Chlorpromazine The metabolism of Sildenafil can be decreased when combined with Chlorpromazine.
Diazepam	Diazepam The metabolism of Diazepam can be decreased when combined with Sildenafil.
Phenoxybenzamine	Phenoxybenzamine The risk or severity of hypotension, dyspepsia, and headache can be increased when Sildenafil is combined with Phenoxybenzamine.
Codeine	Codeine The metabolism of Codeine can be decreased when combined with Sildenafil.
Bromocriptine	Bromocriptine The risk or severity of hypotension, dyspepsia, and headache can be increased when Sildenafil is combined with Bromocriptine.
Tranylcypromine	Tranylcypromine The metabolism of Sildenafil can be decreased when combined with Tranylcypromine.
Phenelzine	Phenelzine The metabolism of Sildenafil can be decreased when combined with Phenelzine.
Procarbazine	Procarbazine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Procarbazine.
Minocycline	Minocycline The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Minocycline.
Prochlorperazine	Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Sildenafil.
Thioridazine	Thioridazine The metabolism of Sildenafil can be decreased when combined with Thioridazine.
Trifluoperazine	Trifluoperazine The risk or severity of hypotension, dyspepsia, and headache can be increased when Sildenafil is combined with Trifluoperazine.
Dapsone	Dapsone The metabolism of Dapsone can be decreased when combined with Sildenafil.
Sulfadiazine	Sulfadiazine The metabolism of Sildenafil can be decreased when combined with Sulfadiazine.
Oxycodone	Oxycodone The metabolism of Oxycodone can be decreased when combined with Sildenafil.
Methadone	Methadone The metabolism of Methadone can be decreased when combined with Sildenafil.
Oxybutynin	Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Sildenafil.
Benztropine	Benztropine The metabolism of Benzatropine can be decreased when combined with Sildenafil.
Maprotiline	Maprotiline The metabolism of Maprotiline can be decreased when combined with Sildenafil.
Ibuprofen	Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Sildenafil.
Orphenadrine	Orphenadrine The metabolism of Sildenafil can be decreased when combined with Orphenadrine.
Perphenazine	Perphenazine The metabolism of Sildenafil can be decreased when combined with Perphenazine.
Fluphenazine	Fluphenazine The metabolism of Sildenafil can be decreased when combined with Fluphenazine.
Amoxapine	Amoxapine The metabolism of Amoxapine can be decreased when combined with Sildenafil.
Hydrocortisone	Hydrocortisone The metabolism of Hydrocortisone can be decreased when combined with Sildenafil.
Doxorubicin	Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Sildenafil.
Cytarabine	Cytarabine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Cytarabine.
Dactinomycin	Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Sildenafil.
Carbamazepine	Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Sildenafil.
Methyldopa	Methyldopa The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Methyldopa.
Clonidine	Clonidine The metabolism of Clonidine can be decreased when combined with Sildenafil.
Prazosin	Prazosin The risk or severity of hypotension, dyspepsia, and headache can be increased when Sildenafil is combined with Prazosin.
Hydralazine	Hydralazine Sildenafil may increase the antihypertensive activities of Hydralazine.
Cimetidine	Cimetidine The metabolism of Sildenafil can be decreased when combined with Cimetidine.
Warfarin	Warfarin The risk or severity of hemorrhage can be increased when Warfarin is combined with Sildenafil.
Loperamide	Loperamide The metabolism of Sildenafil can be decreased when combined with Loperamide.
Promethazine	Promethazine The metabolism of Sildenafil can be decreased when combined with Promethazine.
Daunorubicin	Daunorubicin The metabolism of Sildenafil can be increased when combined with Daunorubicin.
Digoxin	Digoxin Sildenafil may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine	Loxapine The serum concentration of Sildenafil can be increased when it is combined with Loxapine.
Chloroquine	Chloroquine The metabolism of Sildenafil can be decreased when combined with Chloroquine.
Quinine	Quinine The metabolism of Sildenafil can be decreased when combined with Quinine.
Ethosuximide	Ethosuximide The metabolism of Ethosuximide can be decreased when combined with Sildenafil.
Triamterene	Triamterene The risk or severity of hypotension can be increased when Sildenafil is combined with Triamterene.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Sildenafil can be decreased when combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide Sildenafil may increase the antihypertensive activities of Chlorothiazide.
Chlorthalidone	Chlorthalidone Sildenafil may increase the antihypertensive activities of Chlorthalidone.
Metolazone	Metolazone Sildenafil may increase the antihypertensive activities of Metolazone.
Isosorbide	Isosorbide The risk or severity of hypotension can be increased when Isosorbide is combined with Sildenafil.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Sildenafil.
Desipramine	Desipramine The metabolism of Sildenafil can be decreased when combined with Desipramine.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Sildenafil.
Imipramine	Imipramine The metabolism of Imipramine can be decreased when combined with Sildenafil.
Probenecid	Probenecid The metabolism of Sildenafil can be decreased when combined with Probenecid.
Quinidine	Quinidine The serum concentration of Quinidine can be increased when it is combined with Sildenafil.
Procainamide	Procainamide The metabolism of Procainamide can be decreased when combined with Sildenafil.
Isoniazid	Isoniazid The metabolism of Sildenafil can be decreased when combined with Isoniazid.
Rifampin	Rifampin The metabolism of Sildenafil can be increased when combined with Rifampicin.
Valproic Acid	Valproic Acid The metabolism of Sildenafil can be decreased when combined with Valproic acid.
Tamoxifen	Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Sildenafil.
Liothyronine	Liothyronine The excretion of Liothyronine can be decreased when combined with Sildenafil.
Methimazole	Methimazole The metabolism of Sildenafil can be decreased when combined with Methimazole.
Propylthiouracil	Propylthiouracil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Propylthiouracil.
Chlorpropamide	Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Sildenafil.
Tolbutamide	Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Sildenafil.
Tolazamide	Tolazamide The metabolism of Tolazamide can be decreased when combined with Sildenafil.
Dextromethorphan	Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Sildenafil.
Dinoprostone	Dinoprostone The excretion of Dinoprostone can be decreased when combined with Sildenafil.
Niacin	Niacin The metabolism of Sildenafil can be decreased when combined with Niacin.
Baclofen	Baclofen The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Baclofen is combined with Sildenafil.
Clemastine	Clemastine The metabolism of Sildenafil can be decreased when combined with Clemastine.
Chlorpheniramine	Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Sildenafil.
Meclizine	Meclizine The metabolism of Meclizine can be decreased when combined with Sildenafil.
Methyclothiazide	Methyclothiazide The risk or severity of hypotension can be increased when Sildenafil is combined with Methyclothiazide.
Hydrochlorothiazide	Hydrochlorothiazide Sildenafil may increase the antihypertensive activities of Hydrochlorothiazide.
Chlorzoxazone	Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Sildenafil.
Carisoprodol	Carisoprodol The metabolism of Carisoprodol can be decreased when combined with Sildenafil.
Disulfiram	Disulfiram The metabolism of Disulfiram can be decreased when combined with Sildenafil.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The serum concentration of Propranolol can be increased when it is combined with Sildenafil.
Minoxidil	Minoxidil Sildenafil may increase the antihypertensive activities of Minoxidil.
Nortriptyline	Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Sildenafil.
Spironolactone	Spironolactone The risk or severity of hypotension can be increased when Sildenafil is combined with Spironolactone.
Amphotericin B Injection	Amphotericin B Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Amphotericin B.
Nadolol	Nadolol Sildenafil may increase the antihypertensive activities of Nadolol.
Clomiphene	Clomiphene The serum concentration of Clomifene can be increased when it is combined with Sildenafil.
Papaverine	Papaverine The risk or severity of hypotension can be increased when Sildenafil is combined with Papaverine.
Fluorouracil Injection	Fluorouracil Injection The metabolism of Sildenafil can be decreased when combined with Fluorouracil.
Colchicine	Colchicine The serum concentration of Colchicine can be increased when it is combined with Sildenafil.
Ketoconazole	Ketoconazole The serum concentration of Sildenafil can be increased when it is combined with Ketoconazole.
Vincristine Injection	Vincristine Injection The excretion of Vincristine can be decreased when combined with Sildenafil.
Captopril	Captopril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Captopril.
Dipyridamole	Dipyridamole The risk or severity of hemorrhage can be increased when Dipyridamole is combined with Sildenafil.
Isoxsuprine	Isoxsuprine The risk or severity of hypotension can be increased when Sildenafil is combined with Isoxsuprine.
Vinblastine	Vinblastine The serum concentration of Vinblastine can be increased when it is combined with Sildenafil.
Ethacrynic Acid	Ethacrynic Acid The risk or severity of hypotension can be increased when Sildenafil is combined with Etacrynic acid.
Metoprolol	Metoprolol The metabolism of Sildenafil can be decreased when combined with Metoprolol.
Hydroxyzine	Hydroxyzine The metabolism of Sildenafil can be decreased when combined with Hydroxyzine.
Aspirin	Aspirin The risk or severity of hemorrhage can be increased when Acetylsalicylic acid is combined with Sildenafil.
Alprazolam	Alprazolam The metabolism of Alprazolam can be decreased when combined with Sildenafil.
Triazolam	Triazolam The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Triazolam.
Trimethoprim	Trimethoprim The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Trimethoprim.
Diltiazem	Diltiazem The metabolism of Sildenafil can be decreased when combined with Diltiazem.
Nifedipine	Nifedipine The risk or severity of hypotension can be increased when Nifedipine is combined with Sildenafil.
Timolol	Timolol The metabolism of Timolol can be decreased when combined with Sildenafil.
Verapamil	Verapamil The metabolism of Sildenafil can be decreased when combined with Verapamil.
Atenolol	Atenolol Sildenafil may increase the antihypertensive activities of Atenolol.
Pindolol	Pindolol Sildenafil may increase the antihypertensive activities of Pindolol.
Cisplatin Injection	Cisplatin Injection The metabolism of Sildenafil can be decreased when combined with Cisplatin.
Piroxicam	Piroxicam The metabolism of Piroxicam can be decreased when combined with Sildenafil.
Bumetanide	Bumetanide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Bumetanide.
Etoposide	Etoposide The serum concentration of Etoposide can be increased when it is combined with Sildenafil.
Glyburide	Glyburide The metabolism of Sildenafil can be decreased when combined with Glyburide.
Glipizide	Glipizide The metabolism of Glipizide can be decreased when combined with Sildenafil.
Indapamide	Indapamide Sildenafil may increase the antihypertensive activities of Indapamide.
Pentoxifylline	Pentoxifylline The risk or severity of adverse effects can be increased when Sildenafil is combined with Pentoxifylline.
Pentamidine Injection	Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Sildenafil.
Labetalol	Labetalol The metabolism of Labetalol can be decreased when combined with Sildenafil.
Leuprolide Injection	Leuprolide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leuprolide is combined with Sildenafil.
Gemfibrozil	Gemfibrozil The metabolism of Sildenafil can be decreased when combined with Gemfibrozil.
Guanabenz	Guanabenz Sildenafil may increase the antihypertensive activities of Guanabenz.
Pimozide	Pimozide The metabolism of Pimozide can be decreased when combined with Sildenafil.
Enalapril	Enalapril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Enalapril.
Flurbiprofen	Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Sildenafil.
Amiodarone	Amiodarone The metabolism of Sildenafil can be decreased when combined with Amiodarone.
Buspirone	Buspirone The metabolism of Buspirone can be decreased when combined with Sildenafil.
Lovastatin	Lovastatin The metabolism of Lovastatin can be decreased when combined with Sildenafil.
Ciprofloxacin	Ciprofloxacin The metabolism of Sildenafil can be decreased when combined with Ciprofloxacin.
Diclofenac	Diclofenac The metabolism of Diclofenac can be decreased when combined with Sildenafil.
Fluoxetine	Fluoxetine The serum concentration of Sildenafil can be increased when it is combined with Fluoxetine.
Nimodipine	Nimodipine Sildenafil may increase the antihypertensive activities of Nimodipine.
Clozapine	Clozapine The metabolism of Sildenafil can be decreased when combined with Clozapine.
Idarubicin	Idarubicin The metabolism of Idarubicin can be decreased when combined with Sildenafil.
Ofloxacin	Ofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Ofloxacin.
Clarithromycin	Clarithromycin The metabolism of Sildenafil can be decreased when combined with Clarithromycin.
Benazepril	Benazepril Sildenafil may increase the antihypertensive activities of Benazepril.
Etodolac	Etodolac The metabolism of Etodolac can be decreased when combined with Sildenafil.
Felodipine	Felodipine The metabolism of Sildenafil can be decreased when combined with Felodipine.
Fosinopril	Fosinopril Sildenafil may increase the antihypertensive activities of Fosinopril.
Nabumetone	Nabumetone The metabolism of Nabumetone can be decreased when combined with Sildenafil.
Pravastatin	Pravastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Sildenafil.
Quinapril	Quinapril Sildenafil may increase the antihypertensive activities of Quinapril.
Ramipril	Ramipril Sildenafil may increase the antihypertensive activities of Ramipril.
Simvastatin	Simvastatin The metabolism of Sildenafil can be decreased when combined with Simvastatin.
Amlodipine	Amlodipine Sildenafil may increase the antihypertensive activities of Amlodipine.
Teniposide Injection	Teniposide Injection The metabolism of Sildenafil can be decreased when combined with Teniposide.
Itraconazole	Itraconazole The serum concentration of Sildenafil can be increased when it is combined with Itraconazole.
Lisinopril	Lisinopril Sildenafil may increase the antihypertensive activities of Lisinopril.
Atovaquone	Atovaquone The metabolism of Sildenafil can be decreased when combined with Atovaquone.
Sotalol	Sotalol The metabolism of Sotalol can be decreased when combined with Sildenafil.
Bisoprolol	Bisoprolol The serum concentration of Sildenafil can be increased when it is combined with Bisoprolol.
Zolpidem	Zolpidem The metabolism of Zolpidem can be decreased when combined with Sildenafil.
Doxazosin	Doxazosin The risk or severity of hypotension can be increased when Sildenafil is combined with Doxazosin.
Terazosin	Terazosin The risk or severity of hypotension, dyspepsia, and headache can be increased when Sildenafil is combined with Terazosin.
Isradipine	Isradipine Sildenafil may increase the antihypertensive activities of Isradipine.
Omeprazole	Omeprazole The metabolism of Omeprazole can be decreased when combined with Sildenafil.
Cisapride	Cisapride The metabolism of Cisapride can be decreased when combined with Sildenafil.
Fluvastatin	Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Sildenafil.
Venlafaxine	Venlafaxine The metabolism of Sildenafil can be decreased when combined with Venlafaxine.
Nizatidine	Nizatidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Nizatidine.
Stavudine	Stavudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Stavudine.
Fluvoxamine	Fluvoxamine The metabolism of Sildenafil can be decreased when combined with Fluvoxamine.
Nefazodone	Nefazodone The metabolism of Sildenafil can be decreased when combined with Nefazodone.
Losartan	Losartan Sildenafil may increase the antihypertensive activities of Losartan.
Tramadol	Tramadol The metabolism of Sildenafil can be decreased when combined with Tramadol.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Sildenafil can be decreased when combined with Vinorelbine.
Moexipril	Moexipril Sildenafil may increase the antihypertensive activities of Moexipril.
Lansoprazole	Lansoprazole The metabolism of Sildenafil can be decreased when combined with Lansoprazole.
Alprostadil Urogenital	Alprostadil Urogenital The risk or severity of hypotension and priapism can be increased when Sildenafil is combined with Alprostadil.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Sildenafil.
Nicardipine	Nicardipine The metabolism of Sildenafil can be decreased when combined with Nicardipine.
Bupropion	Bupropion The metabolism of Sildenafil can be decreased when combined with Bupropion.
Ticlopidine	Ticlopidine The metabolism of Sildenafil can be decreased when combined with Ticlopidine.
Saquinavir	Saquinavir The metabolism of Saquinavir can be decreased when combined with Sildenafil.
Dalteparin Injection	Dalteparin Injection The risk or severity of hemorrhage can be increased when Dalteparin is combined with Sildenafil.
Nisoldipine	Nisoldipine Sildenafil may increase the antihypertensive activities of Nisoldipine.
Lamivudine	Lamivudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Lamivudine.
Amifostine Injection	Amifostine Injection The risk or severity of hypotension can be increased when Sildenafil is combined with Amifostine.
Glimepiride	Glimepiride The metabolism of Glimepiride can be decreased when combined with Sildenafil.
Gemcitabine Injection	Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Sildenafil.
Indinavir	Indinavir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Indinavir is combined with Sildenafil.
Ritonavir	Ritonavir The serum concentration of Sildenafil can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Sildenafil.
Clomipramine	Clomipramine The metabolism of Clomipramine can be decreased when combined with Sildenafil.
Zafirlukast	Zafirlukast The metabolism of Sildenafil can be decreased when combined with Zafirlukast.
Mirtazapine	Mirtazapine The metabolism of Mirtazapine can be decreased when combined with Sildenafil.
Trandolapril	Trandolapril Sildenafil may increase the antihypertensive activities of Trandolapril.
Zileuton	Zileuton The metabolism of Zileuton can be decreased when combined with Sildenafil.
Valsartan	Valsartan The metabolism of Valsartan can be decreased when combined with Sildenafil.
Pramipexole	Pramipexole The risk or severity of hypotension can be increased when Sildenafil is combined with Pramipexole.
Donepezil	Donepezil The metabolism of Donepezil can be decreased when combined with Sildenafil.
Nelfinavir	Nelfinavir The metabolism of Sildenafil can be decreased when combined with Nelfinavir.
Fexofenadine	Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Sildenafil.
Carvedilol	Carvedilol The risk or severity of hypotension can be increased when Carvedilol is combined with Sildenafil.
Nilutamide	Nilutamide The metabolism of Sildenafil can be decreased when combined with Nilutamide.
Flutamide	Flutamide The metabolism of Flutamide can be decreased when combined with Sildenafil.
Selegiline	Selegiline The metabolism of Selegiline can be decreased when combined with Sildenafil.
Bicalutamide	Bicalutamide The metabolism of Sildenafil can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The metabolism of Sertraline can be decreased when combined with Sildenafil.
Propafenone	Propafenone The metabolism of Sildenafil can be decreased when combined with Propafenone.
Letrozole	Letrozole The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Letrozole.
Raloxifene	Raloxifene The excretion of Raloxifene can be decreased when combined with Sildenafil.
Irbesartan	Irbesartan Sildenafil may increase the antihypertensive activities of Irbesartan.
Tamsulosin	Tamsulosin The risk or severity of hypotension, dyspepsia, and headache can be increased when Sildenafil is combined with Tamsulosin.
Ropinirole	Ropinirole The risk or severity of hypotension can be increased when Sildenafil is combined with Ropinirole.
Finasteride	Finasteride The metabolism of Finasteride can be decreased when combined with Sildenafil.
Quetiapine	Quetiapine The risk or severity of hypotension, dyspepsia, and headache can be increased when Sildenafil is combined with Quetiapine.
Paroxetine	Paroxetine The metabolism of Sildenafil can be decreased when combined with Paroxetine.
Tolcapone	Tolcapone The metabolism of Sildenafil can be decreased when combined with Tolcapone.
Citalopram	Citalopram The risk or severity of QTc prolongation can be increased when Sildenafil is combined with Citalopram.
Capecitabine	Capecitabine The metabolism of Sildenafil can be decreased when combined with Capecitabine.
Efavirenz	Efavirenz The metabolism of Sildenafil can be decreased when combined with Efavirenz.
Celecoxib	Celecoxib The metabolism of Sildenafil can be decreased when combined with Celecoxib.
Rosiglitazone	Rosiglitazone The metabolism of Sildenafil can be decreased when combined with Rosiglitazone.
Tolterodine	Tolterodine The metabolism of Tolterodine can be decreased when combined with Sildenafil.
Thalidomide	Thalidomide The metabolism of Sildenafil can be increased when combined with Thalidomide.
Nateglinide	Nateglinide The metabolism of Nateglinide can be decreased when combined with Sildenafil.
Galantamine	Galantamine The metabolism of Galantamine can be decreased when combined with Sildenafil.
Rabeprazole	Rabeprazole The metabolism of Sildenafil can be decreased when combined with Rabeprazole.
Terbinafine	Terbinafine The metabolism of Sildenafil can be decreased when combined with Terbinafine.