Sildenafil

23 interactions 1 explained in plain English
Also sold as: Liqrev Revatio Revatio® Viagra Viagra® Vybrique
About Sildenafil

A phosphodiesterase inhibitor used to treat erectile dysfunction or pulmonary arterial hypertension. Read the full Sildenafil drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Nitroglycerin Sublingual Nitroglycerin Topical Nitroglycerin Spray Nitroglycerin Nitroglycerin Transdermal Patch Isosorbide Dinitrate
6 Contraindicated 14 Major 3 Moderate
All (23) Contraindicated (6) Major (14) Moderate (3)

Contraindicated

Sildenafil Isosorbide Dinitrate Isochron Potentiation of hypotensive effects Details Sildenafil Nitroglycerin Gonitro Potentiation of hypotensive effects Details Sildenafil Nitroglycerin Spray Nitrolingual Potentiation of hypotensive effects Details Sildenafil Nitroglycerin Sublingual Nitrostat Potentiation of hypotensive effects Details Sildenafil Nitroglycerin Topical Nitro-Bid Potentiation of hypotensive effects Details Sildenafil Nitroglycerin Transdermal Patch Minitran® Patch Potentiation of hypotensive effects Details

Major

Sildenafil Atogepant Qulipta Increased atogepant exposure Details Sildenafil Alfuzosin UroXatral Potentiation of hypotensive effects Details Sildenafil Amlodipine Amvaz® Potentiation of hypotensive effects Details Sildenafil Avanafil Stendra Potentiation of hypotensive effects Details Sildenafil Doxazosin Cardura Potentiation of hypotensive effects Details Sildenafil Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Sildenafil Ketoconazole Topical Extina® Foam Increased sildenafil exposure and an increased risk of prolonged sildenafil adverse effects (headache, flushing, priapism) Details Sildenafil Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Sildenafil Lenacapavir Injection Sunlenca Increased sensitive CYP3A substrate exposure Details Sildenafil Lenacapavir Oral Sunlenca Increased sensitive CYP3A substrate exposure Details Sildenafil Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Sildenafil Mitapivat Aqvesme Reduced sildenafil exposure Details Sildenafil Nafcillin Injection Unipen® Injection Reduced sildenafil exposure Details Sildenafil Olutasidenib Rezlidhia Reduced sensitive CYP3A substrate exposure Details

Moderate

Sildenafil Trospium / Xanomeline Cobenfy Explained Increased oral sensitive CYP3A4 substrate exposure and an increased risk on severity and frequency of sensitive CYP3A4 substrate-r... Details Sildenafil Furosemide Injection Disal Increased risk of hearing loss Details Sildenafil Nebivolol Bystolic Decreased sildenafil exposure and plasma levels and increased risk of hypotension Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.