Pitolisant

Generic name: Pronounced as (pi tol' i sant)
Brand names
  • Wakix®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 12/15/2020

Pitolisant is used to treat excessive daytime sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) and to treat cataplexy (episodes of muscle weakness that begin suddenly and last for a short time) in adults with narcolepsy. Pitolisant is in a class of medications called H3 blockers. It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.

Pitolisant comes as a tablet to take by mouth. It is usually taken once a day with or without food as soon as you wake up in the morning. Take pitolisant at the same time every day. Do not change the time of day that you take pitolisant without talking to your doctor. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pitolisant exactly as directed.

Your doctor will probably start you on a low dose of pitolisant and gradually increase your dose, not more than once every 7 days.

Pitolisant may decrease your sleepiness, but it will not cure your sleep disorder. It may take 8 weeks or longer before you feel the full benefit of pitolisant. Continue to take pitolisant even if you feel well-rested. Do not stop taking pitolisant without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking pitolisant,

  • tell your doctor and pharmacist if you are allergic to pitolisant, any other medications, or any of the ingredients in pitolisant tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone), antihistamines such as diphenhydramine and promethazine, carbamazepine (Carbatrol, Epitol, Tegretol), cyclosporine (Gengraf, Neoral, Sandimmune), bupropion (Aplenzin, Forvivo, Wellbutrin, in Contrave), chlorpromazine, clomipramine (Anafranil), disopyramide (Norpace), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), imipramine (Tofranil), midazolam, mirtazapine (Remeron), moxifloxacin (Avelox), paroxetine (Paxil, Brisdelle, Pexeva), phenytoin (Dilantin, Phenytek), procainamide, rifampin (Rifadin, in Rifamate, in Rifater, Rimactane), quinidine (in Neudexta), sotalol (Betapace, Sorine, Sotylize), thioridazine, and ziprasidone (Geodon). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with pitolisant, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you have liver disease. Your doctor may tell you not to take pitolisant.

  • tell your doctor if you have or have ever had a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death) or a fast, slow, or irregular heartbeat; and if you have low levels of magnesium or potassium in your blood; and if you have kidney disease.

  • you should know that pitolisant may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, injections, and intrauterine devices). Use another form of birth control while taking pitolisant and for 21 days after you stop taking it. Talk to your doctor about types of birth control that will work for you during and after your treatment with pitolisant.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking pitolisant, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Pitolisant may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • difficulty falling asleep or staying asleep

    • nausea

    • stomach pain

    • loss of appetite

    • upper respiratory infection

    • muscle or joint pain

    • sleep talking, sleep terrors, or difficulty moving when sleeping or upon waking

    • muscle weakness that begins suddenly and lasts for a short time

    • rash

    • dry mouth

    • anxiety

    • irritability

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • fast, pounding, or irregular heartbeat

    • difficulty breathing or swallowing

    • fainting

    • hallucinating (seeing things or hearing voices that do not exist)

  • Pitolisant may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin Moxifloxacin may increase the QTc-prolonging activities of Pitolisant.
Repaglinide Repaglinide The serum concentration of Repaglinide can be decreased when it is combined with Pitolisant.
Montelukast Montelukast The serum concentration of Montelukast can be decreased when it is combined with Pitolisant.
Leflunomide Leflunomide The metabolism of Leflunomide can be increased when combined with Pitolisant.
Delavirdine Delavirdine The serum concentration of Delavirdine can be decreased when it is combined with Pitolisant.
Nevirapine Nevirapine The serum concentration of Nevirapine can be decreased when it is combined with Pitolisant.
Atorvastatin Atorvastatin The serum concentration of Atorvastatin can be decreased when it is combined with Pitolisant.
Dolasetron Dolasetron The serum concentration of Dolasetron can be decreased when it is combined with Pitolisant.
Aminophylline Aminophylline The serum concentration of Aminophylline can be decreased when it is combined with Pitolisant.
Anagrelide Anagrelide Pitolisant may increase the QTc-prolonging activities of Anagrelide.
Cilostazol Cilostazol The serum concentration of Cilostazol can be decreased when it is combined with Pitolisant.
Clopidogrel Clopidogrel The serum concentration of Clopidogrel can be decreased when it is combined with Pitolisant.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Erythromycin can be decreased when it is combined with Pitolisant.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The serum concentration of Conjugated estrogens can be decreased when it is combined with Pitolisant.
Fenofibrate Fenofibrate The serum concentration of Fenofibrate can be decreased when it is combined with Pitolisant.
Guanfacine Guanfacine The serum concentration of Guanfacine can be decreased when it is combined with Pitolisant.
Magnesium Hydroxide Magnesium Hydroxide Magnesium hydroxide may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Methylergonovine Methylergonovine The serum concentration of Methylergometrine can be decreased when it is combined with Pitolisant.
Mycophenolate Mycophenolate Mycophenolic acid may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Olsalazine Olsalazine The risk or severity of adverse effects can be increased when Olsalazine is combined with Pitolisant.
Paregoric Paregoric The serum concentration of Morphine can be decreased when it is combined with Pitolisant.
Penbutolol Penbutolol Acebutolol may increase the QTc-prolonging activities of Pitolisant.
Potassium Potassium Potassium cation may increase the excretion rate of Pitolisant which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone The serum concentration of Prednisone can be decreased when it is combined with Pitolisant.
Ranitidine Ranitidine The metabolism of Pitolisant can be decreased when combined with Ranitidine.
Reserpine Reserpine Reserpine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Rizatriptan Rizatriptan Rizatriptan may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Sumatriptan Sumatriptan Sumatriptan may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be decreased when it is combined with Pitolisant.
Tizanidine Tizanidine Pitolisant may increase the QTc-prolonging activities of Tizanidine.
Triamcinolone Triamcinolone The serum concentration of Triamcinolone can be decreased when it is combined with Pitolisant.
Zolmitriptan Zolmitriptan The metabolism of Zolmitriptan can be increased when combined with Pitolisant.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection The serum concentration of Doxycycline can be decreased when it is combined with Pitolisant.
Famotidine Injection Famotidine Injection Famotidine may increase the QTc-prolonging activities of Pitolisant.
Fluconazole Injection Fluconazole Injection Fluconazole may increase the QTc-prolonging activities of Pitolisant.
Foscarnet Injection Foscarnet Injection Foscarnet may increase the QTc-prolonging activities of Pitolisant.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection Pitolisant may increase the QTc-prolonging activities of Levofloxacin.
Meperidine Injection Meperidine Injection The serum concentration of Meperidine can be decreased when it is combined with Pitolisant.
Methylprednisolone Injection Methylprednisolone Injection The serum concentration of Methylprednisolone can be decreased when it is combined with Pitolisant.
Metoclopramide Injection Metoclopramide Injection The serum concentration of Metoclopramide can be decreased when it is combined with Pitolisant.
Metronidazole Injection Metronidazole Injection Metronidazole may increase the QTc-prolonging activities of Pitolisant.
Morphine Injection Morphine Injection The serum concentration of Morphine can be decreased when it is combined with Pitolisant.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Pitolisant may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The serum concentration of Zidovudine can be decreased when it is combined with Pitolisant.
Altretamine Altretamine Amphetamine may decrease the sedative and stimulatory activities of Pitolisant.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be decreased when it is combined with Pitolisant.
Ondansetron Ondansetron The serum concentration of Ondansetron can be decreased when it is combined with Pitolisant.
Granisetron Granisetron The serum concentration of Granisetron can be decreased when it is combined with Pitolisant.
Torsemide Torsemide Torasemide may increase the excretion rate of Pitolisant which could result in a lower serum level and potentially a reduction in efficacy.
Olanzapine Olanzapine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Olanzapine.
Alosetron Alosetron The serum concentration of Alosetron can be decreased when it is combined with Pitolisant.
Dofetilide Dofetilide The serum concentration of Dofetilide can be decreased when it is combined with Pitolisant.
Entacapone Entacapone The metabolism of Pitolisant can be decreased when combined with Entacapone.
Hydroxychloroquine Hydroxychloroquine The serum concentration of Hydroxychloroquine can be decreased when it is combined with Pitolisant.
Meloxicam Meloxicam The risk or severity of adverse effects can be increased when Meloxicam is combined with Pitolisant.
Pantoprazole Pantoprazole The serum concentration of Pantoprazole can be decreased when it is combined with Pitolisant.
Temozolomide Temozolomide Temozolomide may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Zaleplon Zaleplon The serum concentration of Zaleplon can be decreased when it is combined with Pitolisant.
Anakinra Anakinra The metabolism of Pitolisant can be increased when combined with Anakinra.
Desloratadine Desloratadine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Desloratadine.
Trimipramine Trimipramine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Pitolisant can be increased when combined with Etanercept.
Modafinil Modafinil The serum concentration of Modafinil can be decreased when it is combined with Pitolisant.
Perindopril Perindopril Perindopril may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Tenofovir Tenofovir The serum concentration of Tenofovir can be decreased when it is combined with Pitolisant.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of adverse effects can be increased when Choline magnesium trisalicylate is combined with Pitolisant.
Sirolimus Sirolimus The serum concentration of Sirolimus can be decreased when it is combined with Pitolisant.
Epinephrine Injection Epinephrine Injection The risk or severity of adverse effects can be increased when Pitolisant is combined with Epinephrine.
Eplerenone Eplerenone The serum concentration of Eplerenone can be decreased when it is combined with Pitolisant.
Escitalopram Escitalopram The serum concentration of Escitalopram can be decreased when it is combined with Pitolisant.
Zonisamide Zonisamide The serum concentration of Zonisamide can be decreased when it is combined with Pitolisant.
Adalimumab Injection Adalimumab Injection The metabolism of Pitolisant can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The therapeutic efficacy of Pitolisant can be decreased when used in combination with Aripiprazole.
Atomoxetine Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Pitolisant.
Atazanavir Atazanavir The serum concentration of Atazanavir can be decreased when it is combined with Pitolisant.
Almotriptan Almotriptan The serum concentration of Almotriptan can be decreased when it is combined with Pitolisant.
Eletriptan Eletriptan The serum concentration of Eletriptan can be decreased when it is combined with Pitolisant.
Mefloquine Mefloquine The serum concentration of Mefloquine can be decreased when it is combined with Pitolisant.
Rosuvastatin Rosuvastatin The serum concentration of Rosuvastatin can be decreased when it is combined with Pitolisant.
Vardenafil Vardenafil The serum concentration of Vardenafil can be decreased when it is combined with Pitolisant.
Alfuzosin Alfuzosin The serum concentration of Alfuzosin can be decreased when it is combined with Pitolisant.
Aprepitant Aprepitant The serum concentration of Aprepitant can be decreased when it is combined with Pitolisant.
Emtricitabine Emtricitabine Emtricitabine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Memantine Memantine Memantine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Tegaserod Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Pitolisant.
Tadalafil Tadalafil The serum concentration of Tadalafil can be decreased when it is combined with Pitolisant.
Fosamprenavir Fosamprenavir The serum concentration of Fosamprenavir can be decreased when it is combined with Pitolisant.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be increased when combined with Pitolisant.
Gemifloxacin Gemifloxacin Gemifloxacin may increase the QTc-prolonging activities of Pitolisant.
Progesterone Progesterone The serum concentration of Progesterone can be decreased when it is combined with Pitolisant.
Apomorphine Injection Apomorphine Injection Apomorphine may increase the QTc-prolonging activities of Pitolisant.
Infliximab Injection Infliximab Injection The metabolism of Pitolisant can be increased when combined with Infliximab.
Protriptyline Protriptyline The therapeutic efficacy of Pitolisant can be decreased when used in combination with Protriptyline.
Rifaximin Rifaximin The serum concentration of Rifaximin can be decreased when it is combined with Pitolisant.
Duloxetine Duloxetine The serum concentration of Duloxetine can be decreased when it is combined with Pitolisant.
Norethindrone Norethindrone The serum concentration of Norethisterone can be decreased when it is combined with Pitolisant.
Tinidazole Tinidazole The serum concentration of Tinidazole can be decreased when it is combined with Pitolisant.
Trospium Trospium The metabolism of Pitolisant can be decreased when combined with Trospium.
Bosentan Bosentan The serum concentration of Bosentan can be decreased when it is combined with Pitolisant.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Cinacalcet Cinacalcet The serum concentration of Pitolisant can be increased when it is combined with Cinacalcet.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Pitolisant.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Pitolisant.
Ganciclovir Ganciclovir The risk or severity of adverse effects can be increased when Pitolisant is combined with Ganciclovir.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Solifenacin Solifenacin The serum concentration of Solifenacin can be decreased when it is combined with Pitolisant.
Valganciclovir Valganciclovir Valganciclovir may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Voriconazole Voriconazole The serum concentration of Voriconazole can be decreased when it is combined with Pitolisant.
Adefovir Adefovir Adefovir may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the sedative and stimulatory activities of Pitolisant.
Entecavir Entecavir The metabolism of Entecavir can be increased when combined with Pitolisant.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Pitolisant can be decreased when combined with Peginterferon alfa-2b.
Ibandronate Ibandronate Ibandronate may increase the QTc-prolonging activities of Pitolisant.
Ramelteon Ramelteon The serum concentration of Ramelteon can be decreased when it is combined with Pitolisant.
Darifenacin Darifenacin The serum concentration of Darifenacin can be decreased when it is combined with Pitolisant.
Fentanyl Fentanyl The serum concentration of Fentanyl can be decreased when it is combined with Pitolisant.
Pregabalin Pregabalin Pregabalin may increase the QTc-prolonging activities of Pitolisant.
Tipranavir Tipranavir The serum concentration of Tipranavir can be decreased when it is combined with Pitolisant.
Felbamate Felbamate The serum concentration of Felbamate can be decreased when it is combined with Pitolisant.
Ranolazine Ranolazine The metabolism of Pitolisant can be increased when combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Pitolisant can be increased when combined with Abatacept.
Rasagiline Rasagiline The metabolism of Pitolisant can be increased when combined with Rasagiline.
Imatinib Imatinib The serum concentration of Imatinib can be decreased when it is combined with Pitolisant.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be decreased when it is combined with Pitolisant.
Varenicline Varenicline Varenicline may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Gefitinib Gefitinib The serum concentration of Gefitinib can be decreased when it is combined with Pitolisant.
Albuterol Albuterol Salbutamol may increase the QTc-prolonging activities of Pitolisant.
Paliperidone Paliperidone The serum concentration of Paliperidone can be decreased when it is combined with Pitolisant.
Exemestane Exemestane The serum concentration of Exemestane can be decreased when it is combined with Pitolisant.
Bortezomib Bortezomib The serum concentration of Bortezomib can be decreased when it is combined with Pitolisant.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Lubiprostone Lubiprostone Lubiprostone may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection Oxaliplatin may increase the QTc-prolonging activities of Pitolisant.
Posaconazole Posaconazole The serum concentration of Posaconazole can be decreased when it is combined with Pitolisant.
Primaquine Primaquine The serum concentration of Primaquine can be decreased when it is combined with Pitolisant.
Aliskiren Aliskiren The serum concentration of Aliskiren can be decreased when it is combined with Pitolisant.
Darunavir Darunavir The serum concentration of Darunavir can be decreased when it is combined with Pitolisant.
Pemetrexed Injection Pemetrexed Injection Pitolisant may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate The therapeutic efficacy of Pitolisant can be decreased when used in combination with Dimenhydrinate.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may decrease the sedative and stimulatory activities of Pitolisant.
Retapamulin Retapamulin The metabolism of Retapamulin can be increased when combined with Pitolisant.
Vorinostat Vorinostat Vorinostat may increase the QTc-prolonging activities of Pitolisant.
Sorafenib Sorafenib The serum concentration of Sorafenib can be decreased when it is combined with Pitolisant.
Sunitinib Sunitinib The serum concentration of Sunitinib can be decreased when it is combined with Pitolisant.
Dronabinol Dronabinol The serum concentration of Dronabinol can be decreased when it is combined with Pitolisant.
Lapatinib Lapatinib The serum concentration of Lapatinib can be decreased when it is combined with Pitolisant.
Levocetirizine Levocetirizine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Levocetirizine.
Pegaptanib Injection Pegaptanib Injection Pegaptanib may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Dasatinib Dasatinib The serum concentration of Dasatinib can be decreased when it is combined with Pitolisant.
Mexiletine Mexiletine The serum concentration of Mexiletine can be decreased when it is combined with Pitolisant.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Ivermectin Ivermectin The serum concentration of Ivermectin can be decreased when it is combined with Pitolisant.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be decreased when it is combined with Pitolisant.
Maraviroc Maraviroc The serum concentration of Maraviroc can be decreased when it is combined with Pitolisant.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Nilotinib Nilotinib The serum concentration of Nilotinib can be decreased when it is combined with Pitolisant.
Toremifene Toremifene The serum concentration of Toremifene can be decreased when it is combined with Pitolisant.
Bexarotene Bexarotene The serum concentration of Bexarotene can be decreased when it is combined with Pitolisant.
Budesonide Budesonide The serum concentration of Budesonide can be decreased when it is combined with Pitolisant.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Doripenem Injection Doripenem Injection Doripenem may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Etravirine Etravirine The serum concentration of Etravirine can be decreased when it is combined with Pitolisant.
Arsenic Trioxide Injection Arsenic Trioxide Injection Pitolisant may increase the QTc-prolonging activities of Arsenic trioxide.
Desvenlafaxine Desvenlafaxine The serum concentration of Desvenlafaxine can be decreased when it is combined with Pitolisant.
Cevimeline Cevimeline The serum concentration of Cevimeline can be decreased when it is combined with Pitolisant.
Nebivolol Nebivolol The serum concentration of Nebivolol can be decreased when it is combined with Pitolisant.
Tretinoin Tretinoin The serum concentration of Tretinoin can be decreased when it is combined with Pitolisant.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be increased when combined with Pitolisant.
Flecainide Flecainide Flecainide may increase the QTc-prolonging activities of Pitolisant.
Certolizumab Injection Certolizumab Injection The metabolism of Pitolisant can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The serum concentration of Ixabepilone can be decreased when it is combined with Pitolisant.
Irinotecan Injection Irinotecan Injection The serum concentration of Irinotecan can be decreased when it is combined with Pitolisant.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Estramustine Estramustine The serum concentration of Estramustine can be decreased when it is combined with Pitolisant.
Praziquantel Praziquantel The serum concentration of Praziquantel can be decreased when it is combined with Pitolisant.
Mitotane Mitotane The metabolism of Pitolisant can be increased when combined with Mitotane.
Methylnaltrexone Injection Methylnaltrexone Injection Methylnaltrexone may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Rufinamide Rufinamide The serum concentration of Rufinamide can be decreased when it is combined with Pitolisant.
Silodosin Silodosin The serum concentration of Silodosin can be decreased when it is combined with Pitolisant.
Midazolam Midazolam The serum concentration of Midazolam can be decreased when it is combined with Pitolisant.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be increased when combined with Pitolisant.
Milnacipran Milnacipran The serum concentration of Milnacipran can be decreased when it is combined with Pitolisant.
Dexlansoprazole Dexlansoprazole The serum concentration of Dexlansoprazole can be decreased when it is combined with Pitolisant.
Plerixafor Injection Plerixafor Injection Plerixafor may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Fesoterodine Fesoterodine The serum concentration of Fesoterodine can be decreased when it is combined with Pitolisant.
Degarelix Injection Degarelix Injection Degarelix may increase the QTc-prolonging activities of Pitolisant.
Betaxolol Betaxolol Pitolisant may increase the QTc-prolonging activities of Betaxolol.
Iloperidone Iloperidone The therapeutic efficacy of Pitolisant can be decreased when used in combination with Iloperidone.
Prasugrel Prasugrel The serum concentration of Prasugrel can be decreased when it is combined with Pitolisant.
Lacosamide Lacosamide The serum concentration of Lacosamide can be decreased when it is combined with Pitolisant.
Everolimus Everolimus The serum concentration of Everolimus can be decreased when it is combined with Pitolisant.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be decreased when it is combined with Pitolisant.
Dronedarone Dronedarone The serum concentration of Dronedarone can be decreased when it is combined with Pitolisant.
Pralatrexate Injection Pralatrexate Injection Pralatrexate may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection The serum concentration of Palonosetron can be decreased when it is combined with Pitolisant.
Saxagliptin Saxagliptin The serum concentration of Saxagliptin can be decreased when it is combined with Pitolisant.
Telavancin Injection Telavancin Injection Telavancin may increase the QTc-prolonging activities of Pitolisant.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be decreased when it is combined with Pitolisant.
Tapentadol Tapentadol The metabolism of Pitolisant can be decreased when combined with Tapentadol.
Topotecan Topotecan Topotecan may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Golimumab Injection Golimumab Injection The metabolism of Pitolisant can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Pazopanib can be decreased when it is combined with Pitolisant.
Asenapine Asenapine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Asenapine.
Albendazole Albendazole The serum concentration of Albendazole can be decreased when it is combined with Pitolisant.
Ulipristal Ulipristal The serum concentration of Ulipristal can be decreased when it is combined with Pitolisant.
Levonorgestrel Levonorgestrel The serum concentration of Levonorgestrel can be decreased when it is combined with Pitolisant.
Oxymorphone Oxymorphone The serum concentration of Oxymorphone can be decreased when it is combined with Pitolisant.
Tocilizumab Injection Tocilizumab Injection The metabolism of Pitolisant can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Dalfampridine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Fingolimod Fingolimod Fingolimod may increase the QTc-prolonging activities of Pitolisant.
Eribulin Injection Eribulin Injection Eribulin may increase the QTc-prolonging activities of Pitolisant.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Cabazitaxel can be decreased when it is combined with Pitolisant.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Lurasidone Lurasidone The serum concentration of Lurasidone can be decreased when it is combined with Pitolisant.
Acetaminophen Injection Acetaminophen Injection The serum concentration of Acetaminophen can be decreased when it is combined with Pitolisant.
Vilazodone Vilazodone The serum concentration of Vilazodone can be decreased when it is combined with Pitolisant.
Ipilimumab Injection Ipilimumab Injection Ipilimumab may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Terbutaline may increase the QTc-prolonging activities of Pitolisant.
Busulfan Injection Busulfan Injection The serum concentration of Busulfan can be decreased when it is combined with Pitolisant.
Roflumilast Roflumilast The serum concentration of Roflumilast can be decreased when it is combined with Pitolisant.
Linagliptin Linagliptin The serum concentration of Linagliptin can be decreased when it is combined with Pitolisant.
Rilpivirine Rilpivirine The serum concentration of Rilpivirine can be decreased when it is combined with Pitolisant.
Telaprevir Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Pitolisant.
Cyclophosphamide Injection Cyclophosphamide Injection The serum concentration of Cyclophosphamide can be decreased when it is combined with Pitolisant.
Abiraterone Abiraterone The serum concentration of Abiraterone can be decreased when it is combined with Pitolisant.
Triptorelin Injection Triptorelin Injection Triptorelin may increase the QTc-prolonging activities of Pitolisant.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be decreased when it is combined with Pitolisant.
Ticagrelor Ticagrelor The serum concentration of Ticagrelor can be decreased when it is combined with Pitolisant.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be decreased when it is combined with Pitolisant.
Ruxolitinib Ruxolitinib The serum concentration of Ruxolitinib can be decreased when it is combined with Pitolisant.
Vandetanib Vandetanib The serum concentration of Vandetanib can be decreased when it is combined with Pitolisant.
Clobazam Clobazam The serum concentration of Clobazam can be decreased when it is combined with Pitolisant.
Vemurafenib Vemurafenib The serum concentration of Vemurafenib can be decreased when it is combined with Pitolisant.
Vismodegib Vismodegib The serum concentration of Vismodegib can be decreased when it is combined with Pitolisant.
Ivacaftor Ivacaftor The serum concentration of Ivacaftor can be decreased when it is combined with Pitolisant.
Deferiprone Deferiprone Deferiprone may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Axitinib Axitinib The serum concentration of Axitinib can be decreased when it is combined with Pitolisant.
Crizotinib Crizotinib The serum concentration of Crizotinib can be decreased when it is combined with Pitolisant.
Cabergoline Cabergoline The serum concentration of Cabergoline can be decreased when it is combined with Pitolisant.
Naloxone Injection Naloxone Injection Naloxone may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be decreased when it is combined with Pitolisant.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Ezogabine Ezogabine The serum concentration of Tiagabine can be decreased when it is combined with Pitolisant.
Enzalutamide Enzalutamide The metabolism of Pitolisant can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Mirabegron can be decreased when it is combined with Pitolisant.
Regorafenib Regorafenib The serum concentration of Regorafenib can be decreased when it is combined with Pitolisant.
Bosutinib Bosutinib The serum concentration of Bosutinib can be decreased when it is combined with Pitolisant.
Corticotropin, Repository Injection Corticotropin, Repository Injection The serum concentration of Corticotropin can be decreased when it is combined with Pitolisant.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The serum concentration of Cabozantinib can be decreased when it is combined with Pitolisant.
Teduglutide Injection Teduglutide Injection Teduglutide may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Bedaquiline Bedaquiline The serum concentration of Bedaquiline can be decreased when it is combined with Pitolisant.
Tofacitinib Tofacitinib The serum concentration of Tofacitinib can be decreased when it is combined with Pitolisant.
Alogliptin Alogliptin The serum concentration of Alogliptin can be decreased when it is combined with Pitolisant.
Ponatinib Ponatinib The serum concentration of Ponatinib can be decreased when it is combined with Pitolisant.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be decreased when it is combined with Pitolisant.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be decreased when it is combined with Pitolisant.
Apixaban Apixaban The serum concentration of Apixaban can be decreased when it is combined with Pitolisant.
Canagliflozin Canagliflozin The serum concentration of Canagliflozin can be decreased when it is combined with Pitolisant.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Pitolisant which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The serum concentration of Dabrafenib can be decreased when it is combined with Pitolisant.
Ospemifene Ospemifene The serum concentration of Ospemifene can be decreased when it is combined with Pitolisant.
Trametinib Trametinib Trametinib may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Pitolisant.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Pitolisant.
Levomilnacipran Levomilnacipran The serum concentration of Levomilnacipran can be decreased when it is combined with Pitolisant.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Vortioxetine Vortioxetine The serum concentration of Vortioxetine can be decreased when it is combined with Pitolisant.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Pitolisant.
Ibrutinib Ibrutinib The serum concentration of Ibrutinib can be decreased when it is combined with Pitolisant.
Lomitapide Lomitapide The serum concentration of Lomitapide can be decreased when it is combined with Pitolisant.
Avanafil Avanafil The serum concentration of Avanafil can be decreased when it is combined with Pitolisant.
Ketorolac Injection Ketorolac Injection The risk or severity of adverse effects can be increased when Ketorolac is combined with Pitolisant.
Simeprevir Simeprevir The serum concentration of Simeprevir can be decreased when it is combined with Pitolisant.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Pitolisant.
Dapagliflozin Dapagliflozin The serum concentration of Dapagliflozin can be decreased when it is combined with Pitolisant.
Apremilast Apremilast The serum concentration of Apremilast can be decreased when it is combined with Pitolisant.
Droxidopa Droxidopa Droxidopa may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Ceritinib Ceritinib The serum concentration of Ceritinib can be decreased when it is combined with Pitolisant.
Siltuximab Injection Siltuximab Injection The metabolism of Pitolisant can be increased when combined with Siltuximab.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Pitolisant.
Idelalisib Idelalisib The serum concentration of Idelalisib can be decreased when it is combined with Pitolisant.
Testosterone Injection Testosterone Injection The serum concentration of Testosterone can be decreased when it is combined with Pitolisant.
Oritavancin Injection Oritavancin Injection The metabolism of Pitolisant can be decreased when combined with Oritavancin.
Vorapaxar Vorapaxar The serum concentration of Vorapaxar can be decreased when it is combined with Pitolisant.
Hydrocodone Hydrocodone The serum concentration of Hydrocodone can be decreased when it is combined with Pitolisant.
Suvorexant Suvorexant The serum concentration of Suvorexant can be decreased when it is combined with Pitolisant.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Pitolisant.
Olaparib Olaparib The serum concentration of Olaparib can be decreased when it is combined with Pitolisant.
Methamphetamine Methamphetamine Metamfetamine may decrease the sedative and stimulatory activities of Pitolisant.
Tasimelteon Tasimelteon The serum concentration of Tasimelteon can be decreased when it is combined with Pitolisant.
Riociguat Riociguat The serum concentration of Riociguat can be decreased when it is combined with Pitolisant.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be increased when combined with Pitolisant.
Nintedanib Nintedanib The serum concentration of Nintedanib can be decreased when it is combined with Pitolisant.
Secukinumab Injection Secukinumab Injection The metabolism of Pitolisant can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The therapeutic efficacy of Pitolisant can be decreased when used in combination with Risperidone.
Palbociclib Palbociclib The serum concentration of Palbociclib can be decreased when it is combined with Pitolisant.
Lenvatinib Lenvatinib The serum concentration of Lenvatinib can be decreased when it is combined with Pitolisant.
Naloxegol Naloxegol The serum concentration of Naloxegol can be decreased when it is combined with Pitolisant.
Panobinostat Panobinostat The serum concentration of Panobinostat can be decreased when it is combined with Pitolisant.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be decreased when it is combined with Pitolisant.
Ivabradine Ivabradine The serum concentration of Ivabradine can be decreased when it is combined with Pitolisant.
Amiloride Amiloride Amiloride may increase the excretion rate of Pitolisant which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Isavuconazonium can be decreased when it is combined with Pitolisant.
Macitentan Macitentan The serum concentration of Macitentan can be decreased when it is combined with Pitolisant.
Sonidegib Sonidegib The serum concentration of Sonidegib can be decreased when it is combined with Pitolisant.
Flibanserin Flibanserin The serum concentration of Flibanserin can be decreased when it is combined with Pitolisant.
Rolapitant Rolapitant The serum concentration of Rolapitant can be decreased when it is combined with Pitolisant.
Prednisolone Prednisolone The serum concentration of Prednisolone can be decreased when it is combined with Pitolisant.
Daclatasvir Daclatasvir The serum concentration of Daclatasvir can be decreased when it is combined with Pitolisant.
Brexpiprazole Brexpiprazole The serum concentration of Brexpiprazole can be decreased when it is combined with Pitolisant.
Ziprasidone Injection Ziprasidone Injection The therapeutic efficacy of Pitolisant can be decreased when used in combination with Ziprasidone.
Cariprazine Cariprazine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Procaine benzylpenicillin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be decreased when it is combined with Pitolisant.
Trabectedin Injection Trabectedin Injection The serum concentration of Trabectedin can be decreased when it is combined with Pitolisant.
Osimertinib Osimertinib The serum concentration of Osimertinib can be decreased when it is combined with Pitolisant.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Pitolisant.
Ixazomib Ixazomib The serum concentration of Ixazomib can be decreased when it is combined with Pitolisant.
Rifapentine Rifapentine The serum concentration of Rifapentine can be decreased when it is combined with Pitolisant.
Lesinurad Lesinurad Lesinurad may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The metabolism of Pitolisant can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The serum concentration of Brivaracetam can be decreased when it is combined with Pitolisant.
Venetoclax Venetoclax The serum concentration of Venetoclax can be decreased when it is combined with Pitolisant.
Cobicistat Cobicistat The serum concentration of Cobicistat can be decreased when it is combined with Pitolisant.
Selexipag Selexipag The serum concentration of Selexipag can be decreased when it is combined with Pitolisant.
Diphenhydramine Injection Diphenhydramine Injection The therapeutic efficacy of Pitolisant can be decreased when used in combination with Diphenhydramine.
Furosemide Injection Furosemide Injection Furosemide may increase the excretion rate of Pitolisant which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The serum concentration of Rucaparib can be decreased when it is combined with Pitolisant.
Lixisenatide Injection Lixisenatide Injection Lixisenatide may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Ribociclib Ribociclib The serum concentration of Ribociclib can be decreased when it is combined with Pitolisant.
Brigatinib Brigatinib The serum concentration of Brigatinib can be decreased when it is combined with Pitolisant.
Doxepin (Insomnia) Doxepin (Insomnia) The therapeutic efficacy of Pitolisant can be decreased when used in combination with Doxepin.
Deutetrabenazine Deutetrabenazine The serum concentration of Deutetrabenazine can be decreased when it is combined with Pitolisant.
Valbenazine Valbenazine The serum concentration of Valbenazine can be decreased when it is combined with Pitolisant.
Deflazacort Deflazacort The serum concentration of Deflazacort can be decreased when it is combined with Pitolisant.
Safinamide Safinamide The serum concentration of Safinamide can be decreased when it is combined with Pitolisant.
Naldemedine Naldemedine Pitolisant may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Pitolisant can be increased when combined with Midostaurin.
Neratinib Neratinib The serum concentration of Neratinib can be decreased when it is combined with Pitolisant.
Enasidenib Enasidenib The serum concentration of Enasidenib can be decreased when it is combined with Pitolisant.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Pitolisant.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The serum concentration of Fosaprepitant can be decreased when it is combined with Pitolisant.
Benznidazole Benznidazole Pitolisant may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be decreased when it is combined with Pitolisant.
Delafloxacin Delafloxacin Delafloxacin may increase the QTc-prolonging activities of Pitolisant.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be decreased when it is combined with Pitolisant.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Pitolisant.
Acalabrutinib Acalabrutinib The serum concentration of Acalabrutinib can be decreased when it is combined with Pitolisant.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Pitolisant.
Tetrabenazine Tetrabenazine Pitolisant may increase the QTc-prolonging activities of Tetrabenazine.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Pitolisant.
Buprenorphine Injection Buprenorphine Injection The serum concentration of Buprenorphine can be decreased when it is combined with Pitolisant.
Apalutamide Apalutamide The metabolism of Pitolisant can be increased when combined with Apalutamide.
Fostamatinib Fostamatinib The serum concentration of Fostamatinib can be decreased when it is combined with Pitolisant.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Pitolisant.
Baricitinib Baricitinib The serum concentration of Baricitinib can be decreased when it is combined with Pitolisant.
Lofexidine Lofexidine Lofexidine may increase the QTc-prolonging activities of Pitolisant.
Plazomicin Injection Plazomicin Injection Pitolisant may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat Eliglustat The serum concentration of Eliglustat can be decreased when it is combined with Pitolisant.
Encorafenib Encorafenib The serum concentration of Encorafenib can be decreased when it is combined with Pitolisant.
Binimetinib Binimetinib The metabolism of Binimetinib can be increased when combined with Pitolisant.
Ivosidenib Ivosidenib The serum concentration of Ivosidenib can be decreased when it is combined with Pitolisant.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Pitolisant.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Pitolisant.
Eravacycline Injection Eravacycline Injection The serum concentration of Eravacycline can be decreased when it is combined with Pitolisant.
Doravirine Doravirine The serum concentration of Doravirine can be decreased when it is combined with Pitolisant.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Pitolisant.
Cannabidiol Cannabidiol The serum concentration of Cannabidiol can be decreased when it is combined with Pitolisant.
Dacomitinib Dacomitinib The serum concentration of Pitolisant can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib The serum concentration of Duvelisib can be decreased when it is combined with Pitolisant.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Pitolisant.
Stiripentol Stiripentol The metabolism of Pitolisant can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Pitolisant.
Gilteritinib Gilteritinib The serum concentration of Gilteritinib can be decreased when it is combined with Pitolisant.
Glasdegib Glasdegib The serum concentration of Glasdegib can be decreased when it is combined with Pitolisant.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be decreased when it is combined with Pitolisant.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The serum concentration of Paclitaxel can be decreased when it is combined with Pitolisant.
Rifamycin Rifamycin The metabolism of Pitolisant can be increased when combined with Rifamycin.
Prucalopride Prucalopride The serum concentration of Prucalopride can be decreased when it is combined with Pitolisant.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Pitolisant can be increased when combined with Emapalumab.
Siponimod Siponimod The serum concentration of Siponimod can be decreased when it is combined with Pitolisant.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Erdafitinib Erdafitinib The serum concentration of Erdafitinib can be decreased when it is combined with Pitolisant.
Esomeprazole Injection Esomeprazole Injection The serum concentration of Esomeprazole can be decreased when it is combined with Pitolisant.
Alpelisib Alpelisib The serum concentration of Alpelisib can be decreased when it is combined with Pitolisant.
Polatuzumab vedotin-piiq Injection Polatuzumab vedotin-piiq Injection The serum concentration of Polatuzumab vedotin can be decreased when it is combined with Pitolisant.
Solriamfetol Solriamfetol Pitolisant may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Selinexor Selinexor The serum concentration of Selinexor can be decreased when it is combined with Pitolisant.
Darolutamide Darolutamide The serum concentration of Darolutamide can be decreased when it is combined with Pitolisant.
Triclabendazole Triclabendazole The serum concentration of Triclabendazole can be decreased when it is combined with Pitolisant.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Pitolisant.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Pitolisant.
Upadacitinib Upadacitinib The serum concentration of Upadacitinib can be decreased when it is combined with Pitolisant.
Istradefylline Istradefylline The serum concentration of Istradefylline can be decreased when it is combined with Pitolisant.
Pretomanid Pretomanid The serum concentration of Pretomanid can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Fedratinib can be decreased when it is combined with Pitolisant.
Lefamulin Lefamulin Pitolisant may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection Phenytoin Injection The metabolism of Pitolisant can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Pitolisant can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be decreased when it is combined with Pitolisant.
Zanubrutinib Zanubrutinib The serum concentration of Zanubrutinib can be decreased when it is combined with Pitolisant.
Voxelotor Voxelotor The serum concentration of Voxelotor can be decreased when it is combined with Pitolisant.
Avapritinib Avapritinib The serum concentration of Avapritinib can be decreased when it is combined with Pitolisant.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Pitolisant.
Lasmiditan Lasmiditan The serum concentration of Lasmiditan can be increased when it is combined with Pitolisant.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be decreased when it is combined with Pitolisant.
Tazemetostat Tazemetostat The serum concentration of Tazemetostat can be decreased when it is combined with Pitolisant.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Pitolisant.
Pemigatinib Pemigatinib The serum concentration of Pemigatinib can be decreased when it is combined with Pitolisant.
Selumetinib Selumetinib The serum concentration of Selumetinib can be decreased when it is combined with Pitolisant.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Pitolisant.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Pitolisant.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be decreased when it is combined with Pitolisant.
Ripretinib Ripretinib The serum concentration of Ripretinib can be decreased when it is combined with Pitolisant.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Pitolisant.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Pitolisant.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Pitolisant.
Fenfluramine Fenfluramine The metabolism of Pitolisant can be decreased when combined with Fenfluramine.
Fostemsavir Fostemsavir The serum concentration of Pitolisant can be decreased when it is combined with Fostemsavir.
Lurbinectedin Injection Lurbinectedin Injection The serum concentration of Lurbinectedin can be decreased when it is combined with Pitolisant.
Octreotide Octreotide Pitolisant may increase the QTc-prolonging activities of Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Pitolisant.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be decreased when it is combined with Pitolisant.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Pitolisant can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The risk or severity of QTc prolongation can be increased when Relugolix is combined with Pitolisant.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The serum concentration of Drospirenone can be decreased when it is combined with Pitolisant.
Viloxazine Viloxazine Viloxazine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The serum concentration of Vitamin E can be decreased when it is combined with Pitolisant.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Theophylline Theophylline The serum concentration of Theophylline can be decreased when it is combined with Pitolisant.
Fenoprofen Fenoprofen The risk or severity of adverse effects can be increased when Fenoprofen is combined with Pitolisant.
Indomethacin Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Pitolisant.
Mefenamic Acid Mefenamic Acid The risk or severity of adverse effects can be increased when Mefenamic acid is combined with Pitolisant.
Naproxen Naproxen The risk or severity of adverse effects can be increased when Naproxen is combined with Pitolisant.
Tolmetin Tolmetin The risk or severity of adverse effects can be increased when Tolmetin is combined with Pitolisant.
Sulindac Sulindac The risk or severity of adverse effects can be increased when Sulindac is combined with Pitolisant.
Trazodone Trazodone The therapeutic efficacy of Pitolisant can be decreased when used in combination with Trazodone.
Isotretinoin Isotretinoin The serum concentration of Isotretinoin can be decreased when it is combined with Pitolisant.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Hydroxyurea Hydroxyurea The metabolism of Pitolisant can be decreased when combined with Hydroxyurea.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Phenobarbital Phenobarbital The metabolism of Pitolisant can be increased when combined with Phenobarbital.
Metaxalone Metaxalone Metaxalone may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The serum concentration of Pitolisant can be decreased when it is combined with Methotrexate.
Primidone Primidone The metabolism of Pitolisant can be increased when combined with Primidone.
Methsuximide Methsuximide Methsuximide may increase the QTc-prolonging activities of Pitolisant.
Diethylpropion Diethylpropion Diethylpropion may decrease the sedative and stimulatory activities of Pitolisant.
Chlorpromazine Chlorpromazine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Chlorpromazine.
Diazepam Diazepam The serum concentration of Diazepam can be decreased when it is combined with Pitolisant.
Oxazepam Oxazepam Oxazepam may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Flurazepam Flurazepam The serum concentration of Flurazepam can be decreased when it is combined with Pitolisant.
Clorazepate Clorazepate The serum concentration of Clorazepic acid can be decreased when it is combined with Pitolisant.
Lorazepam Lorazepam The serum concentration of Lorazepam can be decreased when it is combined with Pitolisant.
Carmustine Carmustine The metabolism of Pitolisant can be increased when combined with Carmustine.
Amantadine Amantadine Amantadine may increase the QTc-prolonging activities of Pitolisant.
Codeine Codeine The serum concentration of Codeine can be decreased when it is combined with Pitolisant.
Bromocriptine Bromocriptine The serum concentration of Bromocriptine can be decreased when it is combined with Pitolisant.
Tranylcypromine Tranylcypromine The metabolism of Pitolisant can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Pitolisant can be decreased when combined with Phenelzine.
Ergoloid Mesylates Ergoloid Mesylates The serum concentration of Ergoloid mesylate can be decreased when it is combined with Pitolisant.
Tetracycline Tetracycline The serum concentration of Tetracycline can be decreased when it is combined with Pitolisant.
Prochlorperazine Prochlorperazine The serum concentration of Prochlorperazine can be decreased when it is combined with Pitolisant.
Thioridazine Thioridazine The serum concentration of Pitolisant can be increased when it is combined with Thioridazine.
Trifluoperazine Trifluoperazine The metabolism of Trifluoperazine can be increased when combined with Pitolisant.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Dapsone Dapsone The serum concentration of Dapsone can be decreased when it is combined with Pitolisant.
Sulfadiazine Sulfadiazine The serum concentration of Sulfadiazine can be decreased when it is combined with Pitolisant.
Oxycodone Oxycodone The serum concentration of Oxycodone can be decreased when it is combined with Pitolisant.
Methadone Methadone The serum concentration of Methadone can be decreased when it is combined with Pitolisant.
Oxybutynin Oxybutynin The serum concentration of Oxybutynin can be decreased when it is combined with Pitolisant.
Benztropine Benztropine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Benzatropine.
Maprotiline Maprotiline The therapeutic efficacy of Pitolisant can be decreased when used in combination with Maprotiline.
Ibuprofen Ibuprofen The risk or severity of adverse effects can be increased when Ibuprofen is combined with Pitolisant.
Orphenadrine Orphenadrine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Orphenadrine.
Perphenazine Perphenazine The metabolism of Pitolisant can be decreased when combined with Perphenazine.
Azathioprine Azathioprine The metabolism of Pitolisant can be increased when combined with Azathioprine.
Fluphenazine Fluphenazine The metabolism of Pitolisant can be decreased when combined with Fluphenazine.
Phentermine Phentermine The serum concentration of Phentermine can be decreased when it is combined with Pitolisant.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Amoxapine Amoxapine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Amoxapine.
Sulfasalazine Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Pitolisant.
Hydrocortisone Hydrocortisone The serum concentration of Hydrocortisone can be decreased when it is combined with Pitolisant.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be decreased when it is combined with Pitolisant.
Cytarabine Cytarabine The risk or severity of adverse effects can be increased when Pitolisant is combined with Cytarabine.
Dactinomycin Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Pitolisant.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Pitolisant can be increased when combined with Carbamazepine.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Clonidine Clonidine The serum concentration of Clonidine can be decreased when it is combined with Pitolisant.
Prazosin Prazosin The risk or severity of adverse effects can be increased when Pitolisant is combined with Prazosin.
Hydralazine Hydralazine Hydralazine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Cimetidine Cimetidine The metabolism of Pitolisant can be decreased when combined with Cimetidine.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Warfarin Warfarin The serum concentration of Warfarin can be decreased when it is combined with Pitolisant.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Pitolisant.
Loperamide Loperamide The serum concentration of Loperamide can be decreased when it is combined with Pitolisant.
Promethazine Promethazine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Promethazine.
Meclofenamate Meclofenamate The risk or severity of adverse effects can be increased when Meclofenamic acid is combined with Pitolisant.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Digoxin Digoxin Pitolisant may increase the QTc-prolonging activities of Digoxin.
Chloroquine Chloroquine The serum concentration of Chloroquine can be decreased when it is combined with Pitolisant.
Quinine Quinine The serum concentration of Quinine can be decreased when it is combined with Pitolisant.
Ethosuximide Ethosuximide The serum concentration of Ethosuximide can be decreased when it is combined with Pitolisant.
Calcitriol Calcitriol The serum concentration of Calcitriol can be decreased when it is combined with Pitolisant.
Triamterene Triamterene Triamterene may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Sulfinpyrazone Sulfinpyrazone The serum concentration of Sulfinpyrazone can be decreased when it is combined with Pitolisant.
Chlorothiazide Chlorothiazide Chlorothiazide may increase the excretion rate of Pitolisant which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Pitolisant which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may increase the excretion rate of Pitolisant which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Pitolisant.
Clindamycin Injection Clindamycin Injection The serum concentration of Clindamycin can be decreased when it is combined with Pitolisant.
Secobarbital Secobarbital Secobarbital may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Desipramine Desipramine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Desipramine.
Amitriptyline Amitriptyline The therapeutic efficacy of Pitolisant can be decreased when used in combination with Amitriptyline.
Imipramine Imipramine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Imipramine.
Probenecid Probenecid Probenecid may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Quinidine Quinidine The serum concentration of Pitolisant can be increased when it is combined with Quinidine.
Procainamide Procainamide Pitolisant may increase the QTc-prolonging activities of Procainamide.
Isoniazid Isoniazid Isoniazid may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Rifampin Rifampin The metabolism of Pitolisant can be increased when combined with Rifampicin.
Disopyramide Disopyramide The serum concentration of Disopyramide can be decreased when it is combined with Pitolisant.
Valproic Acid Valproic Acid Pitolisant may increase the QTc-prolonging activities of Valproic acid.
Tamoxifen Tamoxifen The serum concentration of Tamoxifen can be decreased when it is combined with Pitolisant.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Methimazole Methimazole The metabolism of Pitolisant can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide Chlorpropamide may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Tolbutamide Tolbutamide Tolbutamide may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Tolazamide Tolazamide Tolazamide may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Dextromethorphan Dextromethorphan The serum concentration of Dextromethorphan can be decreased when it is combined with Pitolisant.
Cyclobenzaprine Cyclobenzaprine The serum concentration of Pitolisant can be decreased when it is combined with Cyclobenzaprine.
Niacin Niacin The metabolism of Pitolisant can be decreased when combined with Niacin.
Baclofen Baclofen Baclofen may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Doxylamine Doxylamine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Doxylamine.
Cyproheptadine Cyproheptadine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Cyproheptadine.
Clemastine Clemastine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Clemastine.
Chlorpheniramine Chlorpheniramine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Chlorpheniramine.
Brompheniramine Brompheniramine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Dexbrompheniramine.
Meclizine Meclizine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Meclizine.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Methyclothiazide Methyclothiazide Methyclothiazide may increase the excretion rate of Pitolisant which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may increase the QTc-prolonging activities of Pitolisant.
Chlorzoxazone Chlorzoxazone The serum concentration of Chlorzoxazone can be decreased when it is combined with Pitolisant.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Disulfiram Disulfiram The serum concentration of Disulfiram can be decreased when it is combined with Pitolisant.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propranolol can be decreased when it is combined with Pitolisant.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may decrease the sedative and stimulatory activities of Pitolisant.
Nortriptyline Nortriptyline The therapeutic efficacy of Pitolisant can be decreased when used in combination with Nortriptyline.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Pitolisant which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Nadolol Nadolol The metabolism of Nadolol can be decreased when combined with Pitolisant.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Oxytocin Injection Oxytocin Injection Oxytocin may increase the QTc-prolonging activities of Pitolisant.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Pitolisant.
Flavoxate Flavoxate Flavoxate may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Papaverine Papaverine Papaverine may increase the QTc-prolonging activities of Pitolisant.
Fluorouracil Injection Fluorouracil Injection Fluorouracil may increase the QTc-prolonging activities of Pitolisant.
Colchicine Colchicine The serum concentration of Colchicine can be decreased when it is combined with Pitolisant.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Cephalexin Cephalexin The serum concentration of Cephalexin can be decreased when it is combined with Pitolisant.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Dacarbazine Dacarbazine The metabolism of Pitolisant can be increased when combined with Dacarbazine.
Acetazolamide Acetazolamide Acetazolamide may increase the excretion rate of Pitolisant which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Ketoconazole Ketoconazole The serum concentration of Ketoconazole can be decreased when it is combined with Pitolisant.
Pyrantel Pyrantel Pyrantel may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Thiotepa Injection Thiotepa Injection The serum concentration of Thiotepa can be decreased when it is combined with Pitolisant.
Vincristine Injection Vincristine Injection The serum concentration of Vincristine can be decreased when it is combined with Pitolisant.
Vinblastine Vinblastine The serum concentration of Vinblastine can be decreased when it is combined with Pitolisant.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Metoprolol Metoprolol The serum concentration of Metoprolol can be decreased when it is combined with Pitolisant.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Pitolisant.
Thiothixene Thiothixene Pitolisant may increase the QTc-prolonging activities of Thiothixene.
Aspirin Aspirin The risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Pitolisant.
Salsalate Salsalate The risk or severity of adverse effects can be increased when Salsalate is combined with Pitolisant.
Alprazolam Alprazolam The serum concentration of Alprazolam can be decreased when it is combined with Pitolisant.
Temazepam Temazepam Temazepam may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Triazolam Triazolam The serum concentration of Triazolam can be decreased when it is combined with Pitolisant.
Dicyclomine Dicyclomine Dicyclomine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Hyoscyamine Hyoscyamine Hyoscyamine may increase the QTc-prolonging activities of Pitolisant.
Propantheline Propantheline Propantheline may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Trimethoprim Trimethoprim The serum concentration of Trimethoprim can be decreased when it is combined with Pitolisant.
Diltiazem Diltiazem The serum concentration of Diltiazem can be decreased when it is combined with Pitolisant.
Nifedipine Nifedipine The serum concentration of Nifedipine can be decreased when it is combined with Pitolisant.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Pitolisant.
Verapamil Verapamil The serum concentration of Verapamil can be decreased when it is combined with Pitolisant.
Atenolol Atenolol The metabolism of Atenolol can be decreased when combined with Pitolisant.
Pindolol Pindolol The metabolism of Pitolisant can be decreased when combined with Pindolol.
Cisplatin Injection Cisplatin Injection Pitolisant may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal The risk or severity of adverse effects can be increased when Diflunisal is combined with Pitolisant.
Piroxicam Piroxicam The risk or severity of adverse effects can be increased when Piroxicam is combined with Pitolisant.
Bumetanide Bumetanide Bumetanide may increase the excretion rate of Pitolisant which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide Etoposide The serum concentration of Etoposide can be decreased when it is combined with Pitolisant.
Glyburide Glyburide The serum concentration of Glyburide can be decreased when it is combined with Pitolisant.
Glipizide Glipizide Glipizide may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Indapamide Indapamide The serum concentration of Indapamide can be decreased when it is combined with Pitolisant.
Amoxicillin Amoxicillin Amoxicillin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Pentoxifylline Pentoxifylline The metabolism of Pitolisant can be increased when combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection Pentamidine may increase the QTc-prolonging activities of Pitolisant.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Labetalol Labetalol The metabolism of Pitolisant can be decreased when combined with Labetalol.
Auranofin Auranofin Auranofin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may increase the QTc-prolonging activities of Pitolisant.
Gemfibrozil Gemfibrozil The serum concentration of Gemfibrozil can be decreased when it is combined with Pitolisant.
Guanabenz Guanabenz The metabolism of Guanabenz can be increased when combined with Pitolisant.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Ketoprofen Ketoprofen The risk or severity of adverse effects can be increased when Ketoprofen is combined with Pitolisant.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Pimozide Pimozide The serum concentration of Pimozide can be decreased when it is combined with Pitolisant.
Flurbiprofen Flurbiprofen The risk or severity of adverse effects can be increased when Flurbiprofen is combined with Pitolisant.
Amiodarone Amiodarone The serum concentration of Amiodarone can be decreased when it is combined with Pitolisant.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Buspirone Buspirone The serum concentration of Buspirone can be decreased when it is combined with Pitolisant.
Lovastatin Lovastatin The serum concentration of Lovastatin can be decreased when it is combined with Pitolisant.
Ciprofloxacin Ciprofloxacin Pitolisant may increase the QTc-prolonging activities of Ciprofloxacin.
Mesalamine Mesalamine The risk or severity of adverse effects can be increased when Mesalazine is combined with Pitolisant.
Diclofenac Diclofenac The risk or severity of adverse effects can be increased when Diclofenac is combined with Pitolisant.
Fluoxetine Fluoxetine The serum concentration of Pitolisant can be increased when it is combined with Fluoxetine.
Nimodipine Nimodipine The serum concentration of Nimodipine can be decreased when it is combined with Pitolisant.
Clozapine Clozapine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Clozapine.
Estazolam Estazolam The serum concentration of Estazolam can be decreased when it is combined with Pitolisant.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Pitolisant.
Ofloxacin Ofloxacin Ofloxacin may increase the QTc-prolonging activities of Pitolisant.
Didanosine Didanosine Didanosine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Clarithromycin Clarithromycin The serum concentration of Clarithromycin can be decreased when it is combined with Pitolisant.
Etodolac Etodolac The risk or severity of adverse effects can be increased when Etodolac is combined with Pitolisant.
Felodipine Felodipine The serum concentration of Felodipine can be decreased when it is combined with Pitolisant.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Nabumetone Nabumetone The risk or severity of adverse effects can be increased when Nabumetone is combined with Pitolisant.
Pravastatin Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Pitolisant.
Simvastatin Simvastatin The serum concentration of Simvastatin can be decreased when it is combined with Pitolisant.
Amlodipine Amlodipine The metabolism of Amlodipine can be increased when combined with Pitolisant.
Teniposide Injection Teniposide Injection The serum concentration of Teniposide can be decreased when it is combined with Pitolisant.
Itraconazole Itraconazole The serum concentration of Pitolisant can be decreased when it is combined with Itraconazole.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Oxaprozin Oxaprozin The risk or severity of adverse effects can be increased when Oxaprozin is combined with Pitolisant.
Atovaquone Atovaquone The serum concentration of Atovaquone can be decreased when it is combined with Pitolisant.
Rifabutin Rifabutin The serum concentration of Rifabutin can be decreased when it is combined with Pitolisant.
Sotalol Sotalol Pitolisant may increase the QTc-prolonging activities of Sotalol.
Bisoprolol Bisoprolol The serum concentration of Bisoprolol can be decreased when it is combined with Pitolisant.
Zolpidem Zolpidem The metabolism of Zolpidem can be increased when combined with Pitolisant.
Doxazosin Doxazosin The serum concentration of Doxazosin can be decreased when it is combined with Pitolisant.
Isradipine Isradipine The serum concentration of Isradipine can be decreased when it is combined with Pitolisant.
Omeprazole Omeprazole The serum concentration of Omeprazole can be decreased when it is combined with Pitolisant.
Cisapride Cisapride The serum concentration of Pitolisant can be increased when it is combined with Cisapride.
Fluvastatin Fluvastatin The serum concentration of Fluvastatin can be decreased when it is combined with Pitolisant.
Venlafaxine Venlafaxine The serum concentration of Venlafaxine can be decreased when it is combined with Pitolisant.
Famciclovir Famciclovir The serum concentration of Famciclovir can be decreased when it is combined with Pitolisant.
Fluvoxamine Fluvoxamine The serum concentration of Fluvoxamine can be decreased when it is combined with Pitolisant.
Nefazodone Nefazodone The serum concentration of Nefazodone can be decreased when it is combined with Pitolisant.
Lamotrigine Lamotrigine The serum concentration of Lamotrigine can be decreased when it is combined with Pitolisant.
Losartan Losartan The serum concentration of Losartan can be decreased when it is combined with Pitolisant.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Tramadol Tramadol The serum concentration of Tramadol can be decreased when it is combined with Pitolisant.
Vinorelbine Injection Vinorelbine Injection The serum concentration of Vinorelbine can be decreased when it is combined with Pitolisant.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Moexipril Moexipril Moexipril may increase the QTc-prolonging activities of Pitolisant.
Lansoprazole Lansoprazole The serum concentration of Lansoprazole can be decreased when it is combined with Pitolisant.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Pitolisant.
Nicardipine Nicardipine The serum concentration of Nicardipine can be decreased when it is combined with Pitolisant.
Bupropion Bupropion The serum concentration of Pitolisant can be increased when it is combined with Bupropion.
Ticlopidine Ticlopidine The serum concentration of Ticlopidine can be decreased when it is combined with Pitolisant.
Saquinavir Saquinavir The serum concentration of Saquinavir can be decreased when it is combined with Pitolisant.
Metformin Metformin The risk or severity of adverse effects can be increased when Pitolisant is combined with Metformin.
Nisoldipine Nisoldipine The serum concentration of Nisoldipine can be decreased when it is combined with Pitolisant.
Lamivudine Lamivudine The risk or severity of adverse effects can be increased when Pitolisant is combined with Lamivudine.
Riluzole Riluzole The metabolism of Riluzole can be increased when combined with Pitolisant.
Acarbose Acarbose Acarbose may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Pitolisant can be increased when it is combined with Gemcitabine.
Indinavir Indinavir The serum concentration of Pitolisant can be decreased when it is combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Ritonavir can be decreased when it is combined with Pitolisant.
Docetaxel Injection Docetaxel Injection The serum concentration of Docetaxel can be decreased when it is combined with Pitolisant.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Clomipramine Clomipramine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Clomipramine.
Zafirlukast Zafirlukast The serum concentration of Pitolisant can be decreased when it is combined with Zafirlukast.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Mirtazapine Mirtazapine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Mirtazapine.
Topiramate Topiramate Topiramate may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Zileuton Zileuton The serum concentration of Zileuton can be decreased when it is combined with Pitolisant.
Pramipexole Pramipexole The risk or severity of adverse effects can be increased when Pitolisant is combined with Pramipexole.
Donepezil Donepezil The serum concentration of Donepezil can be decreased when it is combined with Pitolisant.
Nelfinavir Nelfinavir The serum concentration of Nelfinavir can be decreased when it is combined with Pitolisant.
Fexofenadine Fexofenadine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Fexofenadine.
Azithromycin Azithromycin The serum concentration of Azithromycin can be decreased when it is combined with Pitolisant.
Loratadine Loratadine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Loratadine.
Carvedilol Carvedilol The serum concentration of Carvedilol can be decreased when it is combined with Pitolisant.
Nilutamide Nilutamide Nilutamide may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Flutamide Flutamide The serum concentration of Flutamide can be decreased when it is combined with Pitolisant.
Selegiline Selegiline The serum concentration of Selegiline can be decreased when it is combined with Pitolisant.
Bicalutamide Bicalutamide The serum concentration of Bicalutamide can be decreased when it is combined with Pitolisant.
Sertraline Sertraline The serum concentration of Sertraline can be decreased when it is combined with Pitolisant.
Propafenone Propafenone The serum concentration of Pitolisant can be increased when it is combined with Propafenone.
Letrozole Letrozole The serum concentration of Letrozole can be decreased when it is combined with Pitolisant.
Tamsulosin Tamsulosin The serum concentration of Tamsulosin can be decreased when it is combined with Pitolisant.
Ropinirole Ropinirole The metabolism of Ropinirole can be increased when combined with Pitolisant.
Finasteride Finasteride The serum concentration of Finasteride can be decreased when it is combined with Pitolisant.
Quetiapine Quetiapine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Cetirizine Cetirizine The therapeutic efficacy of Pitolisant can be decreased when used in combination with Cetirizine.
Paroxetine Paroxetine The serum concentration of Pitolisant can be increased when it is combined with Paroxetine.
Tolcapone Tolcapone Tolcapone may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Citalopram Citalopram The serum concentration of Citalopram can be decreased when it is combined with Pitolisant.
Capecitabine Capecitabine Capecitabine may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Efavirenz Efavirenz The serum concentration of Pitolisant can be decreased when it is combined with Efavirenz.
Abacavir Abacavir Abacavir may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Sildenafil Sildenafil The serum concentration of Sildenafil can be decreased when it is combined with Pitolisant.
Pioglitazone Pioglitazone The serum concentration of Pioglitazone can be decreased when it is combined with Pitolisant.
Celecoxib Celecoxib The risk or severity of adverse effects can be increased when Celecoxib is combined with Pitolisant.
Rosiglitazone Rosiglitazone The serum concentration of Rosiglitazone can be decreased when it is combined with Pitolisant.
Tolterodine Tolterodine The serum concentration of Tolterodine can be decreased when it is combined with Pitolisant.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Balsalazide Balsalazide The risk or severity of adverse effects can be increased when Balsalazide is combined with Pitolisant.
Nateglinide Nateglinide The serum concentration of Nateglinide can be decreased when it is combined with Pitolisant.
Galantamine Galantamine The serum concentration of Galantamine can be decreased when it is combined with Pitolisant.
Rabeprazole Rabeprazole The serum concentration of Rabeprazole can be decreased when it is combined with Pitolisant.
Terbinafine Terbinafine The serum concentration of Terbinafine can be decreased when it is combined with Pitolisant.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists