Perphenazine

Generic name: Pronounced as (per fen' a zeen)
Brand names
  • Trilafon®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2018

Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as perphenazine have an increased chance of death during treatment.

Perphenazine is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. Talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is taking perphenazine. For more information, visit the FDA website: http://www.fda.gov/Drugs

Perphenazine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Perphenazine is also used to control severe nausea and vomiting in adults. Perphenazine is in a class of medications called conventional antipsychotics. It works by decreasing abnormal excitement in the brain.

Perphenazine comes as a tablet to take by mouth. It is usually taken two to four times a day. Take perphenazine at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take perphenazine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may start you on an average dose of perphenazine and decrease your dose once your symptoms are controlled. Be sure to tell your doctor how you are feeling during your treatment with perphenazine.

Perphenazine may help to control your symptoms but will not cure your condition. Continue to take perphenazine even if you feel well. Do not stop taking perphenazine without talking to your doctor. If you suddenly stop taking perphenazine, you may experience withdrawal symptoms such as nausea, vomiting, stomach pain, dizziness, and shakiness. Your doctor will probably decrease your dose gradually and may prescribe other medication(s) for you to take for several weeks after you stop taking perphenazine.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking perphenazine,

  • tell your doctor and pharmacist if you are allergic to perphenazine; other phenothiazines such as chlorpromazine, fluphenazine, prochlorperazine (Compazine), promethazine (Phenergan), thioridazine, or trifluoperazine;or any other medications.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); antidepressants; antihistamines; atropine (in Motofen, in Lomotil, in Lonox); barbiturates such as pentobarbital (Nembutal), phenobarbital (Luminal), and secobarbital (Seconal); bupropion (Aplenzin, Wellbutrin, Zyban); chlorpheniramine (in cough and cold medications); cimetidine (Tagamet); clomipramine (Anafranil); duloxetine (Cymbalta); epinephrine (Epipen); haloperidol (Haldol); ipratropium (Atrovent); medications for anxiety or mental illness, irritable bowel disease, motion sickness, Parkinson's disease, seizures, ulcers, or urinary problems; methadone (Dolophine); narcotic medications for pain; quinidine; ritonavir (Norvir, in Kaletra); sedatives; certain selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac), paroxetine (Paxil, Pexeva), and sertraline (Zoloft); sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had brain damage, any condition that affects your blood cells, including conditions that affect the production of blood cells by your bone marrow, trouble keeping your balance, or liver disease. Your doctor may tell you not to take perphenazine.

  • tell your doctor if you have or have ever had pheochromocytoma (tumor on a small gland near the kidneys); breast cancer; seizures; an abnormal electroencephalogram (EEG; test that measures the electrical activity in the brain); depression; conditions that affect your breathing such as asthma, emphysema, or a lung infection; or heart or kidney disease. Also tell your doctor if you are experiencing alcohol withdrawal (symptoms that a person may experience if he/she stops drinking alcohol after drinking heavily for a long time), if you have ever had to stop taking a medication for mental illness due to severe side effects, or if you plan to work with organophosphate insecticides (a type of chemical used to kill insects).

  • if you will be using perphenazine to treat nausea and vomiting, it is important to tell your doctor about any other symptoms you are experiencing, especially listlessness; drowsiness; confusion; aggression; seizures;headaches; problems with vision, hearing, speech, or balance; stomach pain or cramps; or constipation. Nausea and vomiting that is experienced along with these symptoms may be a sign of a more serious condition that should not be treated with perphenazine.

  • tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breast-feeding. If you become pregnant while taking perphenazine, call your doctor. Perphenazine may cause problems in newborns following delivery if it is taken during the last months of pregnancy.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking perphenazine.

  • you should know that this medication may make you drowsy and may affect your thinking and movements. Do not drive a car or operate machinery until you know how this medication affects you.

  • ask your doctor about the safe use of alcohol while you are taking this medication. Alcohol can make the side effects of perphenazine worse.

  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Perphenazine may make your skin sensitive to sunlight.

  • you should know that perphenazine may make it more difficult for your body to cool down when it gets very hot. Tell your doctor if you plan to do vigorous exercise or be exposed to extreme heat.

  • you should know that perphenazine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking perphenazine. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Perphenazine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • dizziness, feeling unsteady, or having trouble keeping your balance

    • blurred vision

    • widening or narrowing of the pupils (black circles in the middle of the eyes)

    • pale skin

    • dry mouth

    • excess saliva

    • stuffed nose

    • headache

    • nausea

    • vomiting

    • diarrhea

    • constipation

    • loss of appetite

    • blank facial expression

    • shuffling walk

    • unusual, slowed, or uncontrollable movements of any part of the body

    • restlessness

    • difficulty falling asleep or staying asleep

    • unusual dreams

    • falsely feeling threatened by others

    • difficult or frequent urination

    • inability to control urination

    • change in skin color

    • breast enlargement

    • breast milk production

    • missed menstrual periods

    • decreased sexual ability in men

  • Some side effects may be serious. If you experience any of the following symptoms, call your doctor immediately:

    • fever

    • muscle stiffness

    • falling

    • confusion

    • fast or irregular heartbeat

    • sweating

    • decreased thirst

    • neck cramps

    • tongue that sticks out of the mouth

    • tightness in the throat

    • difficulty breathing or swallowing

    • fine, worm-like tongue movements

    • uncontrollable, rhythmic face, mouth, or jaw movements

    • seizures

    • eye pain or discoloration

    • vision loss, especially at night

    • seeing everything with a brown tint

    • yellowing of the skin or eyes

    • rash

    • hives

    • itching

    • swelling of the eyes, face, mouth, lips, tongue, throat, arms, hands, feet, ankles, or lower legs

    • difficulty breathing or swallowing

    • slowed heartbeat

    • sore throat, fever, chills, and other signs of infection

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

  • Perphenazine may cause other side effects. Tell your doctor if you have any unusual problems while you are taking this medication.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • difficulty responding to surroundings

  • coma (loss of consciousness for a period of time)

  • seizures

  • fast or irregular heartbeat

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to perphenazine.

Perphenazine may interfere with the results of home pregnancy tests. Tell your doctor if you think you might be pregnant during your treatment with perphenazine. Do not try to test for pregnancy at home.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Duo-Vil® (containing Amitriptyline, Perphenazine)
  • Etrafon® (containing Amitriptyline, Perphenazine)
  • Triavil® (containing Amitriptyline, Perphenazine)

Drug Interaction
Calcium Carbonate Calcium Carbonate Calcium carbonate can cause a decrease in the absorption of Perphenazine enanthate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Perphenazine enanthate.
Paregoric Paregoric The risk or severity of hypotension and CNS depression can be increased when Perphenazine enanthate is combined with Morphine.
Penbutolol Penbutolol The serum concentration of Acebutolol can be increased when it is combined with Perphenazine enanthate.
Zolmitriptan Zolmitriptan The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Perphenazine enanthate.
Cyclosporine Cyclosporine Cyclosporine may increase the neurotoxic activities of Perphenazine enanthate.
Ondansetron Ondansetron The risk or severity of adverse effects can be increased when Ondansetron is combined with Perphenazine enanthate.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Perphenazine enanthate.
Oxcarbazepine Oxcarbazepine The risk or severity of adverse effects can be increased when Oxcarbazepine is combined with Perphenazine enanthate.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Perphenazine enanthate.
Linezolid Linezolid The risk or severity of extrapyramidal symptoms can be increased when Linezolid is combined with Perphenazine enanthate.
Trimipramine Trimipramine The serum concentration of Perphenazine enanthate can be increased when it is combined with Trimipramine.
Glycopyrrolate Glycopyrrolate Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Escitalopram Escitalopram The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Escitalopram.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Perphenazine enanthate.
Almotriptan Almotriptan The risk or severity of adverse effects can be increased when Almotriptan is combined with Perphenazine enanthate.
Eletriptan Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Perphenazine enanthate.
Frovatriptan Frovatriptan The risk or severity of adverse effects can be increased when Frovatriptan is combined with Perphenazine enanthate.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Perphenazine enanthate.
Trospium Trospium Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Solifenacin Solifenacin Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Dextroamphetamine Dextroamphetamine The risk or severity of extrapyramidal symptoms can be increased when Perphenazine enanthate is combined with Amphetamine.
Darifenacin Darifenacin Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Pregabalin Pregabalin The therapeutic efficacy of Perphenazine enanthate can be increased when used in combination with Pregabalin.
Felbamate Felbamate The risk or severity of adverse effects can be increased when Felbamate is combined with Perphenazine enanthate.
Rasagiline Rasagiline The risk or severity of extrapyramidal symptoms can be increased when Rasagiline is combined with Perphenazine enanthate.
Bismuth Subsalicylate Bismuth Subsalicylate Bismuth subsalicylate may increase the neurotoxic activities of Perphenazine enanthate.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Perphenazine enanthate.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Perphenazine enanthate.
Nebivolol Nebivolol The serum concentration of Nebivolol can be increased when it is combined with Perphenazine enanthate.
Betaxolol Betaxolol The serum concentration of Betaxolol can be increased when it is combined with Perphenazine enanthate.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Perphenazine enanthate.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Perphenazine enanthate.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Lurasidone is combined with Perphenazine enanthate.
Vilazodone Vilazodone The risk or severity of adverse effects can be increased when Vilazodone is combined with Perphenazine enanthate.
Cyclophosphamide Injection Cyclophosphamide Injection Cyclophosphamide may increase the neurotoxic activities of Perphenazine enanthate.
Clobazam Clobazam The risk or severity of adverse effects can be increased when Clobazam is combined with Perphenazine enanthate.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Perphenazine enanthate.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Pomalidomide is combined with Perphenazine enanthate.
Levomilnacipran Levomilnacipran The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Levomilnacipran.
Vortioxetine Vortioxetine The risk or severity of adverse effects can be increased when Vortioxetine is combined with Perphenazine enanthate.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Perphenazine enanthate.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Eslicarbazepine is combined with Perphenazine enanthate.
Suvorexant Suvorexant Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Perphenazine enanthate.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Flibanserin is combined with Perphenazine enanthate.
Brexpiprazole Brexpiprazole The risk or severity of adverse effects can be increased when Brexpiprazole is combined with Perphenazine enanthate.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Perphenazine enanthate.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Cariprazine is combined with Perphenazine enanthate.
Eluxadoline Eluxadoline The risk or severity of hypotension and CNS depression can be increased when Perphenazine enanthate is combined with Eluxadoline.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Brivaracetam is combined with Perphenazine enanthate.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Pimavanserin is combined with Perphenazine enanthate.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Perphenazine enanthate.
Deutetrabenazine Deutetrabenazine The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Deutetrabenazine.
Safinamide Safinamide The risk or severity of extrapyramidal symptoms can be increased when Safinamide is combined with Perphenazine enanthate.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Perphenazine enanthate.
Tetrabenazine Tetrabenazine The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Tetrabenazine.
Buprenorphine Injection Buprenorphine Injection Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Lofexidine Lofexidine The therapeutic efficacy of Perphenazine enanthate can be increased when used in combination with Lofexidine.
Tafenoquine Tafenoquine The risk or severity of QTc prolongation can be increased when Tafenoquine is combined with Perphenazine enanthate.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Perphenazine enanthate.
Stiripentol Stiripentol The risk or severity of adverse effects can be increased when Stiripentol is combined with Perphenazine enanthate.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Perphenazine enanthate.
Solriamfetol Solriamfetol The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Solriamfetol.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Perphenazine enanthate.
Lasmiditan Lasmiditan The risk or severity of adverse effects can be increased when Lasmiditan is combined with Perphenazine enanthate.
Lemborexant Lemborexant The risk or severity of adverse effects can be increased when Lemborexant is combined with Perphenazine enanthate.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection Perphenazine enanthate may increase the neurotoxic activities of Naxitamab.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Viloxazine is combined with Perphenazine enanthate.
Trazodone Trazodone The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Trazodone.
Chlorpromazine Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Perphenazine enanthate.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Perphenazine enanthate.
Codeine Codeine The risk or severity of hypotension and CNS depression can be increased when Perphenazine enanthate is combined with Codeine.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Perphenazine enanthate.
Bromocriptine Bromocriptine The risk or severity of adverse effects can be increased when Bromocriptine is combined with Perphenazine enanthate.
Tranylcypromine Tranylcypromine The risk or severity of extrapyramidal symptoms can be increased when Tranylcypromine is combined with Perphenazine enanthate.
Thioridazine Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Perphenazine enanthate.
Trifluoperazine Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Perphenazine enanthate.
Dapsone Dapsone The risk or severity of QTc prolongation can be increased when Dapsone is combined with Perphenazine enanthate.
Oxybutynin Oxybutynin Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine Benztropine Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Trihexyphenidyl Trihexyphenidyl Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Carbamazepine Carbamazepine The risk or severity of adverse effects can be increased when Carbamazepine is combined with Perphenazine enanthate.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Perphenazine enanthate.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Perphenazine enanthate.
Chloroquine Chloroquine The risk or severity of QTc prolongation can be increased when Chloroquine is combined with Perphenazine enanthate.
Clindamycin Injection Clindamycin Injection Clindamycin may increase the neurotoxic activities of Perphenazine enanthate.
Desipramine Desipramine The serum concentration of Desipramine can be increased when it is combined with Perphenazine enanthate.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Perphenazine enanthate.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Perphenazine enanthate.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Perphenazine enanthate.
Chlorpropamide Chlorpropamide The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Perphenazine enanthate.
Tolbutamide Tolbutamide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Perphenazine enanthate.
Tolazamide Tolazamide The therapeutic efficacy of Tolazamide can be decreased when used in combination with Perphenazine enanthate.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Perphenazine enanthate.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Cyclobenzaprine is combined with Perphenazine enanthate.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Perphenazine enanthate.
Cyproheptadine Cyproheptadine Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Perphenazine enanthate.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Chlorpheniramine is combined with Perphenazine enanthate.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Perphenazine enanthate.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Perphenazine enanthate.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Perphenazine enanthate.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Perphenazine enanthate.
Butorphanol Injection Butorphanol Injection The risk or severity of hypotension and CNS depression can be increased when Perphenazine enanthate is combined with Butorphanol.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Perphenazine enanthate.
Vincristine Injection Vincristine Injection Vincristine may increase the neurotoxic activities of Perphenazine enanthate.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Thiothixene is combined with Perphenazine enanthate.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Perphenazine enanthate.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Perphenazine enanthate.
Hyoscyamine Hyoscyamine Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Timolol Timolol The serum concentration of Timolol can be increased when it is combined with Perphenazine enanthate.
Atenolol Atenolol The serum concentration of Atenolol can be increased when it is combined with Perphenazine enanthate.
Clozapine Clozapine The risk or severity of adverse effects can be increased when Clozapine is combined with Perphenazine enanthate.
Teniposide Injection Teniposide Injection Teniposide may increase the neurotoxic activities of Perphenazine enanthate.
Bisoprolol Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Perphenazine enanthate.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Perphenazine enanthate.
Nefazodone Nefazodone The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Perphenazine enanthate.
Tramadol Tramadol The risk or severity of CNS depression can be increased when Perphenazine enanthate is combined with Tramadol.
Glimepiride Glimepiride The therapeutic efficacy of Glimepiride can be decreased when used in combination with Perphenazine enanthate.
Clomipramine Clomipramine The serum concentration of Perphenazine enanthate can be increased when it is combined with Clomipramine.
Mirtazapine Mirtazapine Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Donepezil Donepezil The risk or severity of adverse effects can be increased when Donepezil is combined with Perphenazine enanthate.
Carvedilol Carvedilol The serum concentration of Carvedilol can be increased when it is combined with Perphenazine enanthate.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Perphenazine enanthate.
Paroxetine Paroxetine The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Paroxetine.
Citalopram Citalopram The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Citalopram.
Efavirenz Efavirenz The risk or severity of adverse effects can be increased when Efavirenz is combined with Perphenazine enanthate.
Tolterodine Tolterodine Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide Thalidomide Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Perphenazine enanthate.

* This branded product is no longer on the market. Generic alternatives may be available.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists