Perphenazine

Perphenazine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Perphenazine is also used to control severe nausea and vomiting in adults. Perphenazine is in a class of medications called conventional antipsychotics. It works by decreasing abnormal excitement in the brain.

Perphenazine comes as a tablet to take by mouth. It is usually taken two to four times a day. Take perphenazine at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take perphenazine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may start you on an average dose of perphenazine and decrease your dose once your symptoms are controlled. Be sure to tell your doctor how you are feeling during your treatment with perphenazine.

Perphenazine may help to control your symptoms but will not cure your condition. Continue to take perphenazine even if you feel well. Do not stop taking perphenazine without talking to your doctor. If you suddenly stop taking perphenazine, you may experience withdrawal symptoms such as nausea, vomiting, stomach pain, dizziness, and shakiness. Your doctor will probably decrease your dose gradually and may prescribe other medication(s) for you to take for several weeks after you stop taking perphenazine.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking perphenazine,

• tell your doctor and pharmacist if you are allergic to perphenazine; other phenothiazines such as chlorpromazine, fluphenazine, prochlorperazine (Compazine), promethazine (Phenergan), thioridazine, or trifluoperazine;or any other medications.

• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); antidepressants; antihistamines; atropine (in Motofen, in Lomotil, in Lonox); barbiturates such as pentobarbital (Nembutal), phenobarbital (Luminal), and secobarbital (Seconal); bupropion (Aplenzin, Wellbutrin, Zyban); chlorpheniramine (in cough and cold medications); cimetidine (Tagamet); clomipramine (Anafranil); duloxetine (Cymbalta); epinephrine (Epipen); haloperidol (Haldol); ipratropium (Atrovent); medications for anxiety or mental illness, irritable bowel disease, motion sickness, Parkinson's disease, seizures, ulcers, or urinary problems; methadone (Dolophine); narcotic medications for pain; quinidine; ritonavir (Norvir, in Kaletra); sedatives; certain selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac), paroxetine (Paxil, Pexeva), and sertraline (Zoloft); sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor if you have or have ever had brain damage, any condition that affects your blood cells, including conditions that affect the production of blood cells by your bone marrow, trouble keeping your balance, or liver disease. Your doctor may tell you not to take perphenazine.

• tell your doctor if you have or have ever had pheochromocytoma (tumor on a small gland near the kidneys); breast cancer; seizures; an abnormal electroencephalogram (EEG; test that measures the electrical activity in the brain); depression; conditions that affect your breathing such as asthma, emphysema, or a lung infection; or heart or kidney disease. Also tell your doctor if you are experiencing alcohol withdrawal (symptoms that a person may experience if he/she stops drinking alcohol after drinking heavily for a long time), if you have ever had to stop taking a medication for mental illness due to severe side effects, or if you plan to work with organophosphate insecticides (a type of chemical used to kill insects).

• if you will be using perphenazine to treat nausea and vomiting, it is important to tell your doctor about any other symptoms you are experiencing, especially listlessness; drowsiness; confusion; aggression; seizures;headaches; problems with vision, hearing, speech, or balance; stomach pain or cramps; or constipation. Nausea and vomiting that is experienced along with these symptoms may be a sign of a more serious condition that should not be treated with perphenazine.

• tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breast-feeding. If you become pregnant while taking perphenazine, call your doctor. Perphenazine may cause problems in newborns following delivery if it is taken during the last months of pregnancy.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking perphenazine.

• you should know that this medication may make you drowsy and may affect your thinking and movements. Do not drive a car or operate machinery until you know how this medication affects you.

• ask your doctor about the safe use of alcohol while you are taking this medication. Alcohol can make the side effects of perphenazine worse.

• plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Perphenazine may make your skin sensitive to sunlight.

• you should know that perphenazine may make it more difficult for your body to cool down when it gets very hot. Tell your doctor if you plan to do vigorous exercise or be exposed to extreme heat.

• you should know that perphenazine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking perphenazine. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Perphenazine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dizziness, feeling unsteady, or having trouble keeping your balance

  • blurred vision

  • widening or narrowing of the pupils (black circles in the middle of the eyes)

  • pale skin

  • dry mouth

  • excess saliva

  • stuffed nose

  • headache

  • nausea

  • vomiting

  • diarrhea

  • constipation

  • loss of appetite

  • blank facial expression

  • shuffling walk

  • unusual, slowed, or uncontrollable movements of any part of the body

  • restlessness

  • difficulty falling asleep or staying asleep

  • unusual dreams

  • falsely feeling threatened by others

  • difficult or frequent urination

  • inability to control urination

  • change in skin color

  • breast enlargement

  • breast milk production

  • missed menstrual periods

  • decreased sexual ability in men

• Some side effects may be serious. If you experience any of the following symptoms, call your doctor immediately:

  • fever

  • muscle stiffness

  • falling

  • confusion

  • fast or irregular heartbeat

  • sweating

  • decreased thirst

  • neck cramps

  • tongue that sticks out of the mouth

  • tightness in the throat

  • difficulty breathing or swallowing

  • fine, worm-like tongue movements

  • uncontrollable, rhythmic face, mouth, or jaw movements

  • seizures

  • eye pain or discoloration

  • vision loss, especially at night

  • seeing everything with a brown tint

  • yellowing of the skin or eyes

  • rash

  • hives

  • itching

  • swelling of the eyes, face, mouth, lips, tongue, throat, arms, hands, feet, ankles, or lower legs

  • difficulty breathing or swallowing

  • slowed heartbeat

  • sore throat, fever, chills, and other signs of infection

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

• Perphenazine may cause other side effects. Tell your doctor if you have any unusual problems while you are taking this medication.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• difficulty responding to surroundings

• coma (loss of consciousness for a period of time)

• seizures

• fast or irregular heartbeat

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to perphenazine.

Perphenazine may interfere with the results of home pregnancy tests. Tell your doctor if you think you might be pregnant during your treatment with perphenazine. Do not try to test for pregnancy at home.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

• Duo-Vil^® (containing Amitriptyline, Perphenazine)
• Etrafon^® (containing Amitriptyline, Perphenazine)
• Triavil^® (containing Amitriptyline, Perphenazine)

Drug	Interaction
Calcium Carbonate	Calcium Carbonate Calcium carbonate can cause a decrease in the absorption of Perphenazine enanthate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Naratriptan	Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Perphenazine enanthate.
Paregoric	Paregoric The risk or severity of hypotension and CNS depression can be increased when Perphenazine enanthate is combined with Morphine.
Penbutolol	Penbutolol The serum concentration of Acebutolol can be increased when it is combined with Perphenazine enanthate.
Zolmitriptan	Zolmitriptan The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Perphenazine enanthate.
Cyclosporine	Cyclosporine Cyclosporine may increase the neurotoxic activities of Perphenazine enanthate.
Ondansetron	Ondansetron The risk or severity of adverse effects can be increased when Ondansetron is combined with Perphenazine enanthate.
Granisetron	Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Perphenazine enanthate.
Oxcarbazepine	Oxcarbazepine The risk or severity of adverse effects can be increased when Oxcarbazepine is combined with Perphenazine enanthate.
Desloratadine	Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Perphenazine enanthate.
Linezolid	Linezolid The risk or severity of extrapyramidal symptoms can be increased when Linezolid is combined with Perphenazine enanthate.
Trimipramine	Trimipramine The serum concentration of Perphenazine enanthate can be increased when it is combined with Trimipramine.
Glycopyrrolate	Glycopyrrolate Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Escitalopram	Escitalopram The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Escitalopram.
Teriparatide Injection	Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Perphenazine enanthate.
Almotriptan	Almotriptan The risk or severity of adverse effects can be increased when Almotriptan is combined with Perphenazine enanthate.
Eletriptan	Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Perphenazine enanthate.
Frovatriptan	Frovatriptan The risk or severity of adverse effects can be increased when Frovatriptan is combined with Perphenazine enanthate.
Apomorphine Injection	Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Perphenazine enanthate.
Trospium	Trospium Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Solifenacin	Solifenacin Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Dextroamphetamine	Dextroamphetamine The risk or severity of extrapyramidal symptoms can be increased when Perphenazine enanthate is combined with Amphetamine.
Darifenacin	Darifenacin Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Pregabalin	Pregabalin The therapeutic efficacy of Perphenazine enanthate can be increased when used in combination with Pregabalin.
Felbamate	Felbamate The risk or severity of adverse effects can be increased when Felbamate is combined with Perphenazine enanthate.
Rasagiline	Rasagiline The risk or severity of extrapyramidal symptoms can be increased when Rasagiline is combined with Perphenazine enanthate.
Bismuth Subsalicylate	Bismuth Subsalicylate Bismuth subsalicylate may increase the neurotoxic activities of Perphenazine enanthate.
Nabilone	Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Perphenazine enanthate.
Dronabinol	Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Perphenazine enanthate.
Nebivolol	Nebivolol The serum concentration of Nebivolol can be increased when it is combined with Perphenazine enanthate.
Betaxolol	Betaxolol The serum concentration of Betaxolol can be increased when it is combined with Perphenazine enanthate.
Vigabatrin	Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Perphenazine enanthate.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Perphenazine enanthate.
Lurasidone	Lurasidone The risk or severity of adverse effects can be increased when Lurasidone is combined with Perphenazine enanthate.
Vilazodone	Vilazodone The risk or severity of adverse effects can be increased when Vilazodone is combined with Perphenazine enanthate.
Cyclophosphamide Injection	Cyclophosphamide Injection Cyclophosphamide may increase the neurotoxic activities of Perphenazine enanthate.
Clobazam	Clobazam The risk or severity of adverse effects can be increased when Clobazam is combined with Perphenazine enanthate.
Ezogabine	Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Perphenazine enanthate.
Pomalidomide	Pomalidomide The risk or severity of adverse effects can be increased when Pomalidomide is combined with Perphenazine enanthate.
Levomilnacipran	Levomilnacipran The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Levomilnacipran.
Vortioxetine	Vortioxetine The risk or severity of adverse effects can be increased when Vortioxetine is combined with Perphenazine enanthate.
Perampanel	Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Perphenazine enanthate.
Eslicarbazepine	Eslicarbazepine The risk or severity of adverse effects can be increased when Eslicarbazepine is combined with Perphenazine enanthate.
Suvorexant	Suvorexant Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tasimelteon	Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Perphenazine enanthate.
Flibanserin	Flibanserin The risk or severity of adverse effects can be increased when Flibanserin is combined with Perphenazine enanthate.
Brexpiprazole	Brexpiprazole The risk or severity of adverse effects can be increased when Brexpiprazole is combined with Perphenazine enanthate.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Perphenazine enanthate.
Cariprazine	Cariprazine The risk or severity of adverse effects can be increased when Cariprazine is combined with Perphenazine enanthate.
Eluxadoline	Eluxadoline The risk or severity of hypotension and CNS depression can be increased when Perphenazine enanthate is combined with Eluxadoline.
Brivaracetam Injection	Brivaracetam Injection The risk or severity of adverse effects can be increased when Brivaracetam is combined with Perphenazine enanthate.
Pimavanserin	Pimavanserin The risk or severity of adverse effects can be increased when Pimavanserin is combined with Perphenazine enanthate.
Parathyroid Hormone Injection	Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Perphenazine enanthate.
Deutetrabenazine	Deutetrabenazine The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Deutetrabenazine.
Safinamide	Safinamide The risk or severity of extrapyramidal symptoms can be increased when Safinamide is combined with Perphenazine enanthate.
Abaloparatide Injection	Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Perphenazine enanthate.
Tetrabenazine	Tetrabenazine The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Tetrabenazine.
Buprenorphine Injection	Buprenorphine Injection Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Lofexidine	Lofexidine The therapeutic efficacy of Perphenazine enanthate can be increased when used in combination with Lofexidine.
Tafenoquine	Tafenoquine The risk or severity of QTc prolongation can be increased when Tafenoquine is combined with Perphenazine enanthate.
Cannabidiol	Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Perphenazine enanthate.
Stiripentol	Stiripentol The risk or severity of adverse effects can be increased when Stiripentol is combined with Perphenazine enanthate.
Brexanolone Injection	Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Perphenazine enanthate.
Solriamfetol	Solriamfetol The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Solriamfetol.
Lumateperone	Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Perphenazine enanthate.
Lasmiditan	Lasmiditan The risk or severity of adverse effects can be increased when Lasmiditan is combined with Perphenazine enanthate.
Lemborexant	Lemborexant The risk or severity of adverse effects can be increased when Lemborexant is combined with Perphenazine enanthate.
Naxitamab-gqgk Injection	Naxitamab-gqgk Injection Perphenazine enanthate may increase the neurotoxic activities of Naxitamab.
Viloxazine	Viloxazine The risk or severity of adverse effects can be increased when Viloxazine is combined with Perphenazine enanthate.
Trazodone	Trazodone The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Trazodone.
Chlorpromazine	Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Perphenazine enanthate.
Clorazepate	Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Perphenazine enanthate.
Codeine	Codeine The risk or severity of hypotension and CNS depression can be increased when Perphenazine enanthate is combined with Codeine.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Perphenazine enanthate.
Bromocriptine	Bromocriptine The risk or severity of adverse effects can be increased when Bromocriptine is combined with Perphenazine enanthate.
Tranylcypromine	Tranylcypromine The risk or severity of extrapyramidal symptoms can be increased when Tranylcypromine is combined with Perphenazine enanthate.
Thioridazine	Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Perphenazine enanthate.
Trifluoperazine	Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Perphenazine enanthate.
Dapsone	Dapsone The risk or severity of QTc prolongation can be increased when Dapsone is combined with Perphenazine enanthate.
Oxybutynin	Oxybutynin Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine	Benztropine Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Trihexyphenidyl	Trihexyphenidyl Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Carbamazepine	Carbamazepine The risk or severity of adverse effects can be increased when Carbamazepine is combined with Perphenazine enanthate.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Perphenazine enanthate.
Clonazepam	Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Perphenazine enanthate.
Chloroquine	Chloroquine The risk or severity of QTc prolongation can be increased when Chloroquine is combined with Perphenazine enanthate.
Clindamycin Injection	Clindamycin Injection Clindamycin may increase the neurotoxic activities of Perphenazine enanthate.
Desipramine	Desipramine The serum concentration of Desipramine can be increased when it is combined with Perphenazine enanthate.
Valproic Acid	Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Perphenazine enanthate.
Levothyroxine	Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Perphenazine enanthate.
Liothyronine	Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Perphenazine enanthate.
Chlorpropamide	Chlorpropamide The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Perphenazine enanthate.
Tolbutamide	Tolbutamide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Perphenazine enanthate.
Tolazamide	Tolazamide The therapeutic efficacy of Tolazamide can be decreased when used in combination with Perphenazine enanthate.
Dextromethorphan	Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Perphenazine enanthate.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of CNS depression can be increased when Cyclobenzaprine is combined with Perphenazine enanthate.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Perphenazine enanthate.
Cyproheptadine	Cyproheptadine Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine	Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Perphenazine enanthate.
Chlorpheniramine	Chlorpheniramine The risk or severity of adverse effects can be increased when Chlorpheniramine is combined with Perphenazine enanthate.
Brompheniramine	Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Perphenazine enanthate.
Dantrolene	Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Perphenazine enanthate.
Chlorzoxazone	Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Perphenazine enanthate.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Perphenazine enanthate.
Butorphanol Injection	Butorphanol Injection The risk or severity of hypotension and CNS depression can be increased when Perphenazine enanthate is combined with Butorphanol.
Acetazolamide	Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Perphenazine enanthate.
Vincristine Injection	Vincristine Injection Vincristine may increase the neurotoxic activities of Perphenazine enanthate.
Thiothixene	Thiothixene The risk or severity of adverse effects can be increased when Thiothixene is combined with Perphenazine enanthate.
Temazepam	Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Perphenazine enanthate.
Triazolam	Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Perphenazine enanthate.
Hyoscyamine	Hyoscyamine Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Timolol	Timolol The serum concentration of Timolol can be increased when it is combined with Perphenazine enanthate.
Atenolol	Atenolol The serum concentration of Atenolol can be increased when it is combined with Perphenazine enanthate.
Clozapine	Clozapine The risk or severity of adverse effects can be increased when Clozapine is combined with Perphenazine enanthate.
Teniposide Injection	Teniposide Injection Teniposide may increase the neurotoxic activities of Perphenazine enanthate.
Bisoprolol	Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Perphenazine enanthate.
Gabapentin	Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Perphenazine enanthate.
Nefazodone	Nefazodone The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Nefazodone.
Lamotrigine	Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Perphenazine enanthate.
Tramadol	Tramadol The risk or severity of CNS depression can be increased when Perphenazine enanthate is combined with Tramadol.
Glimepiride	Glimepiride The therapeutic efficacy of Glimepiride can be decreased when used in combination with Perphenazine enanthate.
Clomipramine	Clomipramine The serum concentration of Perphenazine enanthate can be increased when it is combined with Clomipramine.
Mirtazapine	Mirtazapine Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Donepezil	Donepezil The risk or severity of adverse effects can be increased when Donepezil is combined with Perphenazine enanthate.
Carvedilol	Carvedilol The serum concentration of Carvedilol can be increased when it is combined with Perphenazine enanthate.
Cetirizine	Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Perphenazine enanthate.
Paroxetine	Paroxetine The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Paroxetine.
Citalopram	Citalopram The risk or severity of adverse effects can be increased when Perphenazine enanthate is combined with Citalopram.
Efavirenz	Efavirenz The risk or severity of adverse effects can be increased when Efavirenz is combined with Perphenazine enanthate.
Tolterodine	Tolterodine Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide	Thalidomide Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Levetiracetam	Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Perphenazine enanthate.