Selumetinib
Generic name: Pronounced as (sel" ue me' ti nib)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 05/15/2020
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
Why is this medication prescribed?
Selumetinib is used to treat neurofibromatosis type 1 (NF1; a nervous system disorder that causes tumors to grow on nerves) in children 2 years of age and older who have plexiform neurofibromas (PN; soft tumors) that cannot be completely removed by surgery. Selumetinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals the tumors to grow. This helps to stop or slow tumor growth.
How should this medicine be used?
Selumetinib comes as a capsule to take by mouth. It is usually taken twice a day on an empty stomach. Do not eat any food 2 hours before or for 1 hour after each dose. Take selumetinib at around the same time(s) every day, approximately 12 hours apart. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take selumetinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the capsules whole with water; do not open, chew, or crush them.
If you vomit after taking selumetinib, do not take another dose. Continue your regular dosing schedule.
Your doctor may decrease your dose or temporarily or permanently stop your treatment if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with selumetinib.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking selumetinib,
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tell your doctor and pharmacist if you are allergic to selumetinib, any other medications, or any of the ingredients in selumetinib capsules. Ask your pharmacist for a list of the ingredients.
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tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend); aprepitant (Emend); clarithromycin (Biaxin, in Prevpac); clopidogrel (Plavix); corticosteroids such as betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, Dexpak, Dexasone, others), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol, Meprolone, others), prednisolone (Prelone, others), and prednisone (Rayos); diltiazem (Cardizem, Dilacor, Tiazac, others); erythromycin (E.E.S., E-Mycin, Erythrocin); certain medications for HIV including indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Fortovase, Invirase); idelalisib (Zydelig); nefazodone; phenobarbital; rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); verapamil (Calan, Covera); and vitamin E supplements. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
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tell your doctor what herbal products you are taking, especially St. John's wort.
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tell your doctor if you have or have ever had vision problems, difficulty swallowing, or heart or liver disease.
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tell your doctor if you are pregnant, plan to become pregnant, or if you plan on fathering a child. If you are female, you will need to take a pregnancy test before you start treatment and use birth control to prevent pregnancy during your treatment and for at least 1 week after your final dose. If you are a male, you and your partner should use birth control during your treatment with selumetinib and for 1 week after your final dose. Talk to your doctor about birth control methods that you can use during your treatment. If you or your partner become pregnant while taking selumetinib, call your doctor immediately. Selumetinib may harm the fetus.
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tell your doctor if you are breastfeeding. You should not breastfeed while you are taking selumetinib and for 1 week after the final dose.
What special dietary instructions should I follow?
Avoid eating grapefruit or drinking grapefruit juice while taking this medication.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is within 6 hours of the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
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Selumetinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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vomiting
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constipation
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stomach pain
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nausea
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dry skin
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headache
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mouth ulcers
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itching
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redness around the fingernails
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nose bleeding
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fatigue
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loss of appetite
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hair loss or hair color changes
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Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
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fever
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unusual bleeding
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pale skin or tiredness
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blurred vision; loss of vision; dark spots in your vision; or other vision changes
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diarrhea
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rash, skin blisters or peeling
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muscle pain, aches, or weakness; or dark urine
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coughing or wheezing; shortness of breath; swelling of ankles and feet; or extreme tiredness
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Selumetinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not remove the desiccant (small packet included with the capsules to absorb moisture) from your bottle.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What OTHER INFORMATION should I know?
Keep all appointments with your doctor, eye doctor, and the laboratory. Your doctor will order certain lab tests, including eye exams, before, during, and after your treatment to check your body's response to selumetinib.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
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Moxifloxacin | Moxifloxacin The metabolism of Selumetinib can be decreased when combined with Moxifloxacin. |
Repaglinide | Repaglinide The metabolism of Selumetinib can be decreased when combined with Repaglinide. |
Montelukast | Montelukast The metabolism of Selumetinib can be decreased when combined with Montelukast. |
Insulin Glargine (rDNA origin) Injection | Insulin Glargine (rDNA origin) Injection The metabolism of Selumetinib can be increased when combined with Insulin glargine. |
Leflunomide | Leflunomide The serum concentration of Selumetinib can be decreased when it is combined with Leflunomide. |
Delavirdine | Delavirdine The serum concentration of Selumetinib can be increased when it is combined with Delavirdine. |
Nevirapine | Nevirapine The metabolism of Selumetinib can be decreased when combined with Nevirapine. |
Atorvastatin | Atorvastatin The metabolism of Selumetinib can be decreased when combined with Atorvastatin. |
Aminophylline | Aminophylline The metabolism of Selumetinib can be decreased when combined with Aminophylline. |
Anagrelide | Anagrelide The metabolism of Selumetinib can be decreased when combined with Anagrelide. |
Candesartan | Candesartan The metabolism of Selumetinib can be decreased when combined with Candesartan. |
Cilostazol | Cilostazol The metabolism of Selumetinib can be decreased when combined with Cilostazol. |
Clopidogrel | Clopidogrel The metabolism of Selumetinib can be decreased when combined with Clopidogrel. |
Erythromycin and Sulfisoxazole | Erythromycin and Sulfisoxazole The serum concentration of Selumetinib can be increased when it is combined with Erythromycin. |
Estrogen and Progestin (Oral Contraceptives) | Estrogen and Progestin (Oral Contraceptives) The metabolism of Selumetinib can be decreased when combined with Conjugated estrogens. |
Fenofibrate | Fenofibrate The metabolism of Selumetinib can be decreased when combined with Fenofibrate. |
Paregoric | Paregoric The metabolism of Selumetinib can be decreased when combined with Morphine. |
Ranitidine | Ranitidine The metabolism of Selumetinib can be decreased when combined with Ranitidine. |
Reserpine | Reserpine The serum concentration of Selumetinib can be increased when it is combined with Reserpine. |
Tacrolimus | Tacrolimus The metabolism of Selumetinib can be decreased when combined with Tacrolimus. |
Tizanidine | Tizanidine The metabolism of Selumetinib can be decreased when combined with Tizanidine. |
Triamcinolone | Triamcinolone The metabolism of Selumetinib can be increased when combined with Triamcinolone. |
Zolmitriptan | Zolmitriptan The metabolism of Selumetinib can be decreased when combined with Zolmitriptan. |
Famotidine Injection | Famotidine Injection The metabolism of Selumetinib can be decreased when combined with Famotidine. |
Fluconazole Injection | Fluconazole Injection The serum concentration of Selumetinib can be increased when it is combined with Fluconazole. |
Hydromorphone Injection | Hydromorphone Injection The metabolism of Selumetinib can be decreased when combined with Hydromorphone. |
Interferon Beta-1b Injection | Interferon Beta-1b Injection The metabolism of Selumetinib can be decreased when combined with Interferon beta-1b. |
Interferon Gamma-1b Injection | Interferon Gamma-1b Injection The metabolism of Selumetinib can be decreased when combined with Interferon gamma-1b. |
Levofloxacin Injection | Levofloxacin Injection The metabolism of Selumetinib can be decreased when combined with Levofloxacin. |
Meperidine Injection | Meperidine Injection The metabolism of Selumetinib can be increased when combined with Meperidine. |
Metoclopramide Injection | Metoclopramide Injection The metabolism of Selumetinib can be decreased when combined with Metoclopramide. |
Metronidazole Injection | Metronidazole Injection The metabolism of Selumetinib can be decreased when combined with Metronidazole. |
Morphine Injection | Morphine Injection The metabolism of Selumetinib can be decreased when combined with Morphine. |
Zidovudine Injection | Zidovudine Injection The metabolism of Selumetinib can be increased when combined with Zidovudine. |
Cyclosporine | Cyclosporine The serum concentration of Selumetinib can be increased when it is combined with Cyclosporine. |
Ondansetron | Ondansetron The metabolism of Selumetinib can be decreased when combined with Ondansetron. |
Torsemide | Torsemide The metabolism of Selumetinib can be decreased when combined with Torasemide. |
Olanzapine | Olanzapine The metabolism of Selumetinib can be decreased when combined with Olanzapine. |
Alosetron | Alosetron The metabolism of Selumetinib can be decreased when combined with Alosetron. |
Hydroxychloroquine | Hydroxychloroquine The metabolism of Selumetinib can be decreased when combined with Hydroxychloroquine. |
Meloxicam | Meloxicam The metabolism of Selumetinib can be decreased when combined with Meloxicam. |
Oxcarbazepine | Oxcarbazepine The metabolism of Selumetinib can be increased when combined with Oxcarbazepine. |
Pantoprazole | Pantoprazole Pantoprazole may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Telmisartan | Telmisartan Telmisartan may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Zaleplon | Zaleplon The metabolism of Selumetinib can be decreased when combined with Zaleplon. |
Anakinra | Anakinra The metabolism of Selumetinib can be increased when combined with Anakinra. |
Trimipramine | Trimipramine The metabolism of Selumetinib can be decreased when combined with Trimipramine. |
Etanercept Injection | Etanercept Injection The metabolism of Selumetinib can be increased when combined with Etanercept. |
Modafinil | Modafinil The serum concentration of Selumetinib can be decreased when it is combined with Modafinil. |
Tenofovir | Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Selumetinib. |
Sirolimus | Sirolimus The metabolism of Selumetinib can be decreased when combined with Sirolimus. |
Dutasteride | Dutasteride The metabolism of Selumetinib can be decreased when combined with Dutasteride. |
Epinephrine Injection | Epinephrine Injection The metabolism of Selumetinib can be decreased when combined with Epinephrine. |
Eplerenone | Eplerenone The metabolism of Selumetinib can be decreased when combined with Eplerenone. |
Escitalopram | Escitalopram The metabolism of Selumetinib can be decreased when combined with Escitalopram. |
Zonisamide | Zonisamide The serum concentration of Selumetinib can be increased when it is combined with Zonisamide. |
Adalimumab Injection | Adalimumab Injection The metabolism of Selumetinib can be increased when combined with Adalimumab. |
Aripiprazole | Aripiprazole The metabolism of Selumetinib can be decreased when combined with Aripiprazole. |
Teriparatide Injection | Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Selumetinib. |
Atazanavir | Atazanavir The serum concentration of Selumetinib can be increased when it is combined with Atazanavir. |
Almotriptan | Almotriptan The metabolism of Selumetinib can be decreased when combined with Almotriptan. |
Eletriptan | Eletriptan The metabolism of Selumetinib can be decreased when combined with Eletriptan. |
Rosuvastatin | Rosuvastatin The metabolism of Selumetinib can be decreased when combined with Rosuvastatin. |
Vardenafil | Vardenafil The serum concentration of Selumetinib can be increased when it is combined with Vardenafil. |
Aprepitant | Aprepitant The serum concentration of Selumetinib can be increased when it is combined with Aprepitant. |
Interferon Beta-1a Subcutaneous Injection | Interferon Beta-1a Subcutaneous Injection The metabolism of Selumetinib can be decreased when combined with Interferon beta-1a. |
Memantine | Memantine The metabolism of Selumetinib can be decreased when combined with Memantine. |
Tegaserod | Tegaserod The metabolism of Selumetinib can be decreased when combined with Tegaserod. |
Tadalafil | Tadalafil The metabolism of Selumetinib can be decreased when combined with Tadalafil. |
Frovatriptan | Frovatriptan The metabolism of Selumetinib can be decreased when combined with Frovatriptan. |
Gemifloxacin | Gemifloxacin The metabolism of Selumetinib can be decreased when combined with Gemifloxacin. |
Progesterone | Progesterone Progesterone may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Apomorphine Injection | Apomorphine Injection The metabolism of Selumetinib can be decreased when combined with Apomorphine. |
Infliximab Injection | Infliximab Injection The metabolism of Selumetinib can be increased when combined with Infliximab. |
Oxandrolone | Oxandrolone The metabolism of Selumetinib can be decreased when combined with Oxandrolone. |
Rifaximin | Rifaximin The serum concentration of Selumetinib can be decreased when it is combined with Rifaximin. |
Duloxetine | Duloxetine The metabolism of Selumetinib can be decreased when combined with Duloxetine. |
Norethindrone | Norethindrone The metabolism of Selumetinib can be decreased when combined with Norethisterone. |
Bosentan | Bosentan The serum concentration of Selumetinib can be decreased when it is combined with Bosentan. |
Cinacalcet | Cinacalcet The metabolism of Selumetinib can be decreased when combined with Cinacalcet. |
Erlotinib | Erlotinib The metabolism of Selumetinib can be decreased when combined with Erlotinib. |
Eszopiclone | Eszopiclone The metabolism of Selumetinib can be decreased when combined with Eszopiclone. |
Voriconazole | Voriconazole The serum concentration of Selumetinib can be increased when it is combined with Voriconazole. |
Entecavir | Entecavir The metabolism of Selumetinib can be decreased when combined with Entecavir. |
Peginterferon Alfa-2a Injection | Peginterferon Alfa-2a Injection The metabolism of Selumetinib can be decreased when combined with Peginterferon alfa-2a. |
Peginterferon Alfa-2b (PEG-Intron) | Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Selumetinib can be increased when it is combined with Peginterferon alfa-2b. |
Ramelteon | Ramelteon The metabolism of Selumetinib can be decreased when combined with Ramelteon. |
Fentanyl | Fentanyl The metabolism of Selumetinib can be decreased when combined with Fentanyl. |
Deferasirox | Deferasirox The serum concentration of Selumetinib can be increased when it is combined with Deferasirox. |
Phenylephrine | Phenylephrine The metabolism of Selumetinib can be increased when combined with Phenylephrine. |
Tipranavir | Tipranavir The serum concentration of Selumetinib can be increased when it is combined with Tipranavir. |
Felbamate | Felbamate The metabolism of Selumetinib can be decreased when combined with Felbamate. |
Ranolazine | Ranolazine The serum concentration of Selumetinib can be increased when it is combined with Ranolazine. |
Abatacept Injection | Abatacept Injection The metabolism of Selumetinib can be increased when combined with Abatacept. |
Rasagiline | Rasagiline The metabolism of Selumetinib can be decreased when combined with Rasagiline. |
Imatinib | Imatinib The metabolism of Selumetinib can be decreased when combined with Imatinib. |
Sitagliptin | Sitagliptin The metabolism of Selumetinib can be decreased when combined with Sitagliptin. |
Gefitinib | Gefitinib Gefitinib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Paliperidone | Paliperidone The serum concentration of Selumetinib can be increased when it is combined with Paliperidone. |
Bortezomib | Bortezomib The metabolism of Selumetinib can be decreased when combined with Bortezomib. |
Insulin Glulisine (rDNA origin) Injection | Insulin Glulisine (rDNA origin) Injection The metabolism of Selumetinib can be increased when combined with Insulin glulisine. |
Posaconazole | Posaconazole The serum concentration of Selumetinib can be increased when it is combined with Posaconazole. |
Primaquine | Primaquine The serum concentration of Selumetinib can be increased when it is combined with Primaquine. |
Darunavir | Darunavir The serum concentration of Selumetinib can be increased when it is combined with Darunavir. |
Pemetrexed Injection | Pemetrexed Injection The metabolism of Selumetinib can be decreased when combined with Pemetrexed. |
Nabilone | Nabilone The metabolism of Selumetinib can be decreased when combined with Nabilone. |
Sorafenib | Sorafenib The metabolism of Selumetinib can be decreased when combined with Sorafenib. |
Sunitinib | Sunitinib The metabolism of Selumetinib can be decreased when combined with Sunitinib. |
Dronabinol | Dronabinol Dronabinol may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Lapatinib | Lapatinib The serum concentration of Selumetinib can be increased when it is combined with Lapatinib. |
Dasatinib | Dasatinib The metabolism of Selumetinib can be decreased when combined with Dasatinib. |
Mexiletine | Mexiletine The metabolism of Selumetinib can be decreased when combined with Mexiletine. |
Armodafinil | Armodafinil The metabolism of Selumetinib can be decreased when combined with Armodafinil. |
Temsirolimus | Temsirolimus The metabolism of Selumetinib can be decreased when combined with Temsirolimus. |
Nilotinib | Nilotinib The serum concentration of Selumetinib can be increased when it is combined with Nilotinib. |
Toremifene | Toremifene The serum concentration of Selumetinib can be increased when it is combined with Toremifene. |
Bexarotene | Bexarotene The serum concentration of Selumetinib can be decreased when it is combined with Bexarotene. |
Budesonide | Budesonide The metabolism of Selumetinib can be increased when combined with Budesonide. |
Chloramphenicol Injection | Chloramphenicol Injection The metabolism of Selumetinib can be decreased when combined with Chloramphenicol. |
Etravirine | Etravirine The serum concentration of Selumetinib can be decreased when it is combined with Etravirine. |
Mitoxantrone Injection | Mitoxantrone Injection The metabolism of Selumetinib can be increased when combined with Mitoxantrone. |
Desvenlafaxine | Desvenlafaxine The serum concentration of Selumetinib can be increased when it is combined with Desvenlafaxine. |
Nebivolol | Nebivolol The metabolism of Selumetinib can be decreased when combined with Nebivolol. |
Tretinoin | Tretinoin The metabolism of Selumetinib can be decreased when combined with Tretinoin. |
Bendamustine Injection | Bendamustine Injection The metabolism of Selumetinib can be decreased when combined with Bendamustine. |
Flecainide | Flecainide The metabolism of Selumetinib can be decreased when combined with Flecainide. |
Certolizumab Injection | Certolizumab Injection The metabolism of Selumetinib can be increased when combined with Certolizumab pegol. |
Irinotecan Injection | Irinotecan Injection The metabolism of Selumetinib can be decreased when combined with Irinotecan. |
Praziquantel | Praziquantel The metabolism of Selumetinib can be decreased when combined with Praziquantel. |
Mitotane | Mitotane The serum concentration of Selumetinib can be decreased when it is combined with Mitotane. |
Rufinamide | Rufinamide The metabolism of Selumetinib can be decreased when combined with Rufinamide. |
Silodosin | Silodosin The serum concentration of Selumetinib can be increased when it is combined with Silodosin. |
Midazolam | Midazolam The metabolism of Selumetinib can be decreased when combined with Midazolam. |
Eltrombopag | Eltrombopag The metabolism of Selumetinib can be decreased when combined with Eltrombopag. |
Milnacipran | Milnacipran The serum concentration of Selumetinib can be increased when it is combined with Milnacipran. |
Dexlansoprazole | Dexlansoprazole The metabolism of Selumetinib can be decreased when combined with Dexlansoprazole. |
Betaxolol | Betaxolol The metabolism of Selumetinib can be decreased when combined with Betaxolol. |
Iloperidone | Iloperidone The metabolism of Selumetinib can be decreased when combined with Iloperidone. |
Prasugrel | Prasugrel The metabolism of Selumetinib can be decreased when combined with Prasugrel. |
Lacosamide | Lacosamide The metabolism of Selumetinib can be decreased when combined with Lacosamide. |
Everolimus | Everolimus The serum concentration of Selumetinib can be increased when it is combined with Everolimus. |
Tolvaptan (low blood sodium) | Tolvaptan (low blood sodium) The serum concentration of Selumetinib can be increased when it is combined with Tolvaptan. |
Dronedarone | Dronedarone The serum concentration of Selumetinib can be increased when it is combined with Dronedarone. |
Saxagliptin | Saxagliptin The metabolism of Selumetinib can be decreased when combined with Saxagliptin. |
Romidepsin Injection | Romidepsin Injection The serum concentration of Selumetinib can be increased when it is combined with Romidepsin. |
Tapentadol | Tapentadol The metabolism of Selumetinib can be decreased when combined with Tapentadol. |
Topotecan | Topotecan The serum concentration of Topotecan can be increased when it is combined with Selumetinib. |
Golimumab Injection | Golimumab Injection The metabolism of Selumetinib can be increased when combined with Golimumab. |
Pazopanib | Pazopanib The metabolism of Selumetinib can be decreased when combined with Pazopanib. |
Asenapine | Asenapine The metabolism of Selumetinib can be decreased when combined with Asenapine. |
Pitavastatin | Pitavastatin The metabolism of Selumetinib can be decreased when combined with Pitavastatin. |
Albendazole | Albendazole The metabolism of Selumetinib can be decreased when combined with Albendazole. |
Levonorgestrel | Levonorgestrel The metabolism of Selumetinib can be decreased when combined with Levonorgestrel. |
Tocilizumab Injection | Tocilizumab Injection The metabolism of Selumetinib can be increased when combined with Tocilizumab. |
Fingolimod | Fingolimod The metabolism of Selumetinib can be decreased when combined with Fingolimod. |
Cabazitaxel Injection | Cabazitaxel Injection The metabolism of Selumetinib can be decreased when combined with Cabazitaxel. |
Acetaminophen Injection | Acetaminophen Injection Selumetinib may increase the hepatotoxic activities of Acetaminophen. |
Vilazodone | Vilazodone The metabolism of Selumetinib can be decreased when combined with Vilazodone. |
Denileukin Diftitox Injection | Denileukin Diftitox Injection The metabolism of Selumetinib can be decreased when combined with Aldesleukin. |
Linagliptin | Linagliptin The serum concentration of Selumetinib can be increased when it is combined with Linagliptin. |
Rilpivirine | Rilpivirine Rilpivirine may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Telaprevir | Telaprevir Glecaprevir may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Potassium Iodide | Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Selumetinib. |
Cyclophosphamide Injection | Cyclophosphamide Injection The metabolism of Selumetinib can be decreased when combined with Cyclophosphamide. |
Abiraterone | Abiraterone The serum concentration of Selumetinib can be increased when it is combined with Abiraterone. |
Rivaroxaban | Rivaroxaban The serum concentration of Selumetinib can be increased when it is combined with Rivaroxaban. |
Ticagrelor | Ticagrelor The serum concentration of Selumetinib can be increased when it is combined with Ticagrelor. |
Brentuximab Vedotin Injection | Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Selumetinib. |
Vandetanib | Vandetanib Vandetanib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Clobazam | Clobazam The metabolism of Selumetinib can be decreased when combined with Clobazam. |
Vemurafenib | Vemurafenib The serum concentration of Selumetinib can be increased when it is combined with Vemurafenib. |
Vismodegib | Vismodegib Vismodegib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Ivacaftor | Ivacaftor The serum concentration of Selumetinib can be increased when it is combined with Ivacaftor. |
Axitinib | Axitinib The metabolism of Selumetinib can be decreased when combined with Axitinib. |
Crizotinib | Crizotinib The serum concentration of Selumetinib can be increased when it is combined with Crizotinib. |
Cabergoline | Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Selumetinib. |
Naloxone Injection | Naloxone Injection The serum concentration of Selumetinib can be increased when it is combined with Naloxone. |
Ambrisentan | Ambrisentan The serum concentration of Selumetinib can be increased when it is combined with Ambrisentan. |
Carfilzomib Injection | Carfilzomib Injection The serum concentration of Selumetinib can be increased when it is combined with Carfilzomib. |
Enzalutamide | Enzalutamide The serum concentration of Selumetinib can be decreased when it is combined with Enzalutamide. |
Mirabegron | Mirabegron The serum concentration of Selumetinib can be increased when it is combined with Mirabegron. |
Regorafenib | Regorafenib Regorafenib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Bosutinib | Bosutinib The metabolism of Selumetinib can be decreased when combined with Bosutinib. |
Teriflunomide | Teriflunomide The serum concentration of Selumetinib can be decreased when it is combined with Teriflunomide. |
Cabozantinib (thyroid cancer) | Cabozantinib (thyroid cancer) The metabolism of Selumetinib can be decreased when combined with Cabozantinib. |
Ponatinib | Ponatinib The metabolism of Selumetinib can be decreased when combined with Ponatinib. |
Pomalidomide | Pomalidomide The metabolism of Selumetinib can be decreased when combined with Pomalidomide. |
Ado-trastuzumab Emtansine Injection | Ado-trastuzumab Emtansine Injection The metabolism of Selumetinib can be decreased when combined with Trastuzumab emtansine. |
Apixaban | Apixaban The metabolism of Selumetinib can be decreased when combined with Apixaban. |
Canagliflozin | Canagliflozin The serum concentration of Selumetinib can be increased when it is combined with Canagliflozin. |
Dabrafenib | Dabrafenib The serum concentration of Selumetinib can be decreased when it is combined with Dabrafenib. |
Ospemifene | Ospemifene The metabolism of Selumetinib can be decreased when combined with Ospemifene. |
Trametinib | Trametinib The metabolism of Selumetinib can be decreased when combined with Trametinib. |
Dolutegravir | Dolutegravir The serum concentration of Selumetinib can be increased when it is combined with Dolutegravir. |
Afatinib | Afatinib Afatinib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Levomilnacipran | Levomilnacipran The metabolism of Selumetinib can be decreased when combined with Levomilnacipran. |
Vortioxetine | Vortioxetine The metabolism of Selumetinib can be decreased when combined with Vortioxetine. |
Perampanel | Perampanel The metabolism of Selumetinib can be decreased when combined with Perampanel. |
Ibrutinib | Ibrutinib The metabolism of Selumetinib can be decreased when combined with Ibrutinib. |
Lomitapide | Lomitapide The serum concentration of Selumetinib can be increased when it is combined with Lomitapide. |
Ketorolac Injection | Ketorolac Injection The metabolism of Selumetinib can be decreased when combined with Ketorolac. |
Simeprevir | Simeprevir The serum concentration of Selumetinib can be increased when it is combined with Simeprevir. |
Sofosbuvir | Sofosbuvir The serum concentration of Selumetinib can be increased when it is combined with Sofosbuvir. |
Dapagliflozin | Dapagliflozin The metabolism of Selumetinib can be decreased when combined with Dapagliflozin. |
Apremilast | Apremilast The metabolism of Selumetinib can be increased when combined with Apremilast. |
Ceritinib | Ceritinib The metabolism of Selumetinib can be decreased when combined with Ceritinib. |
Siltuximab Injection | Siltuximab Injection The metabolism of Selumetinib can be increased when combined with Siltuximab. |
Eslicarbazepine | Eslicarbazepine The metabolism of Selumetinib can be decreased when combined with Eslicarbazepine. |
Belinostat Injection | Belinostat Injection The serum concentration of Selumetinib can be increased when it is combined with Belinostat. |
Idelalisib | Idelalisib The serum concentration of Selumetinib can be increased when it is combined with Idelalisib. |
Testosterone Injection | Testosterone Injection The metabolism of Selumetinib can be decreased when combined with Testosterone. |
Oritavancin Injection | Oritavancin Injection The metabolism of Selumetinib can be decreased when combined with Oritavancin. |
Vorapaxar | Vorapaxar The serum concentration of Selumetinib can be increased when it is combined with Vorapaxar. |
Suvorexant | Suvorexant The serum concentration of Selumetinib can be increased when it is combined with Suvorexant. |
Edoxaban | Edoxaban The serum concentration of Selumetinib can be increased when it is combined with Edoxaban. |
Peginterferon Beta-1a Injection | Peginterferon Beta-1a Injection The metabolism of Selumetinib can be decreased when combined with Peginterferon beta-1a. |
Olaparib | Olaparib The metabolism of Selumetinib can be decreased when combined with Olaparib. |
Tasimelteon | Tasimelteon The metabolism of Selumetinib can be decreased when combined with Tasimelteon. |
Riociguat | Riociguat The metabolism of Selumetinib can be decreased when combined with Riociguat. |
Pirfenidone | Pirfenidone The metabolism of Selumetinib can be decreased when combined with Pirfenidone. |
Nintedanib | Nintedanib The serum concentration of Selumetinib can be increased when it is combined with Nintedanib. |
Secukinumab Injection | Secukinumab Injection The metabolism of Selumetinib can be increased when combined with Secukinumab. |
Risperidone Injection | Risperidone Injection The metabolism of Selumetinib can be decreased when combined with Risperidone. |
Palbociclib | Palbociclib Palbociclib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Insulin Human Inhalation | Insulin Human Inhalation The metabolism of Selumetinib can be increased when combined with Insulin human. |
Lenvatinib | Lenvatinib The metabolism of Selumetinib can be decreased when combined with Lenvatinib. |
Naloxegol | Naloxegol The metabolism of Selumetinib can be decreased when combined with Naloxegol. |
Panobinostat | Panobinostat The serum concentration of Selumetinib can be increased when it is combined with Panobinostat. |
Haloperidol Injection | Haloperidol Injection The serum concentration of Selumetinib can be increased when it is combined with Haloperidol. |
Isavuconazonium Injection | Isavuconazonium Injection The serum concentration of Selumetinib can be increased when it is combined with Isavuconazonium. |
Flibanserin | Flibanserin The serum concentration of Selumetinib can be increased when it is combined with Flibanserin. |
Rolapitant | Rolapitant Rolapitant may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Daclatasvir | Daclatasvir Daclatasvir may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Ziprasidone Injection | Ziprasidone Injection The serum concentration of Selumetinib can be increased when it is combined with Ziprasidone. |
Insulin Degludec (rDNA Origin) Injection | Insulin Degludec (rDNA Origin) Injection The metabolism of Selumetinib can be increased when combined with Insulin degludec. |
Cobimetinib | Cobimetinib The serum concentration of Selumetinib can be increased when it is combined with Cobimetinib. |
Trabectedin Injection | Trabectedin Injection The metabolism of Selumetinib can be decreased when combined with Trabectedin. |
Osimertinib | Osimertinib The serum concentration of Selumetinib can be decreased when it is combined with Osimertinib. |
Alectinib | Alectinib Alectinib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Rifapentine | Rifapentine The metabolism of Selumetinib can be increased when combined with Rifapentine. |
Lesinurad | Lesinurad The metabolism of Selumetinib can be decreased when combined with Lesinurad. |
Dexamethasone Injection | Dexamethasone Injection The serum concentration of Selumetinib can be decreased when it is combined with Dexamethasone. |
Brivaracetam Injection | Brivaracetam Injection The metabolism of Selumetinib can be decreased when combined with Brivaracetam. |
Venetoclax | Venetoclax The serum concentration of Selumetinib can be increased when it is combined with Venetoclax. |
Cobicistat | Cobicistat The serum concentration of Selumetinib can be increased when it is combined with Cobicistat. |
Selexipag | Selexipag The metabolism of Selumetinib can be decreased when combined with Selexipag. |
Obeticholic Acid | Obeticholic Acid The metabolism of Selumetinib can be decreased when combined with Obeticholic acid. |
Diphenhydramine Injection | Diphenhydramine Injection The metabolism of Selumetinib can be decreased when combined with Diphenhydramine. |
Rucaparib | Rucaparib Rucaparib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Ribociclib | Ribociclib The serum concentration of Selumetinib can be increased when it is combined with Ribociclib. |
Parathyroid Hormone Injection | Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Selumetinib. |
Brigatinib | Brigatinib The metabolism of Selumetinib can be decreased when combined with Brigatinib. |
Doxepin (Insomnia) | Doxepin (Insomnia) The metabolism of Selumetinib can be decreased when combined with Doxepin. |
Deutetrabenazine | Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Selumetinib. |
Valbenazine | Valbenazine The metabolism of Valbenazine can be decreased when combined with Selumetinib. |
Deflazacort | Deflazacort The metabolism of Selumetinib can be increased when combined with Deflazacort. |
Safinamide | Safinamide Safinamide may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Midostaurin | Midostaurin The serum concentration of Selumetinib can be increased when it is combined with Midostaurin. |
Neratinib | Neratinib The serum concentration of Selumetinib can be increased when it is combined with Neratinib. |
Abaloparatide Injection | Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Selumetinib. |
Enasidenib | Enasidenib The metabolism of Selumetinib can be decreased when combined with Enasidenib. |
Inotuzumab Ozogamicin Injection | Inotuzumab Ozogamicin Injection The serum concentration of Selumetinib can be increased when it is combined with Inotuzumab ozogamicin. |
Copanlisib Injection | Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Selumetinib. |
Delafloxacin | Delafloxacin The metabolism of Selumetinib can be increased when combined with Delafloxacin. |
Abemaciclib | Abemaciclib Abemaciclib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Betrixaban | Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Selumetinib. |
Acalabrutinib | Acalabrutinib The metabolism of Selumetinib can be decreased when combined with Acalabrutinib. |
Letermovir | Letermovir Letermovir may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Ertugliflozin | Ertugliflozin The metabolism of Selumetinib can be decreased when combined with Ertugliflozin. |
Buprenorphine Injection | Buprenorphine Injection Buprenorphine may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Apalutamide | Apalutamide The serum concentration of Selumetinib can be decreased when it is combined with Apalutamide. |
Fostamatinib | Fostamatinib Fostamatinib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Avatrombopag | Avatrombopag Avatrombopag may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Baricitinib | Baricitinib Baricitinib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Lofexidine | Lofexidine The metabolism of Selumetinib can be decreased when combined with Lofexidine. |
Eliglustat | Eliglustat The serum concentration of Selumetinib can be increased when it is combined with Eliglustat. |
Binimetinib | Binimetinib The metabolism of Binimetinib can be decreased when combined with Selumetinib. |
Ivosidenib | Ivosidenib The serum concentration of Selumetinib can be increased when it is combined with Ivosidenib. |
Lusutrombopag | Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Selumetinib. |
Elagolix | Elagolix The serum concentration of Selumetinib can be increased when it is combined with Elagolix. |
Doravirine | Doravirine The metabolism of Doravirine can be decreased when combined with Selumetinib. |
Cannabidiol | Cannabidiol Cannabidiol may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Dacomitinib | Dacomitinib The metabolism of Selumetinib can be decreased when combined with Dacomitinib. |
Duvelisib | Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Selumetinib. |
Omadacycline | Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Selumetinib. |
Sarecycline | Sarecycline The serum concentration of Selumetinib can be increased when it is combined with Sarecycline. |
Stiripentol | Stiripentol The serum concentration of Selumetinib can be increased when it is combined with Stiripentol. |
Talazoparib | Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Selumetinib. |
Gilteritinib | Gilteritinib Gilteritinib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Glasdegib | Glasdegib Glasdegib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Lorlatinib | Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Selumetinib. |
Larotrectinib | Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Selumetinib. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection The metabolism of Selumetinib can be decreased when combined with Paclitaxel. |
Rifamycin | Rifamycin The serum concentration of Selumetinib can be decreased when it is combined with Rifamycin. |
Emapalumab-lzsg Injection | Emapalumab-lzsg Injection The metabolism of Selumetinib can be increased when combined with Emapalumab. |
Siponimod | Siponimod The metabolism of Siponimod can be decreased when combined with Selumetinib. |
Acyclovir Ophthalmic | Acyclovir Ophthalmic The metabolism of Selumetinib can be decreased when combined with Acyclovir. |
Erdafitinib | Erdafitinib The serum concentration of Selumetinib can be increased when it is combined with Erdafitinib. |
Esomeprazole Injection | Esomeprazole Injection The metabolism of Selumetinib can be decreased when combined with Esomeprazole. |
Alpelisib | Alpelisib The serum concentration of Selumetinib can be decreased when it is combined with Alpelisib. |
Darolutamide | Darolutamide The serum concentration of Selumetinib can be increased when it is combined with Darolutamide. |
Triclabendazole | Triclabendazole The metabolism of Selumetinib can be decreased when combined with Triclabendazole. |
Entrectinib | Entrectinib The serum concentration of Selumetinib can be increased when it is combined with Entrectinib. |
Pexidartinib | Pexidartinib The metabolism of Selumetinib can be decreased when combined with Pexidartinib. |
Istradefylline | Istradefylline Istradefylline may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Pitolisant | Pitolisant The serum concentration of Selumetinib can be decreased when it is combined with Pitolisant. |
Fedratinib | Fedratinib Fedratinib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Lefamulin | Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Selumetinib. |
Phenytoin Injection | Phenytoin Injection The serum concentration of Selumetinib can be decreased when it is combined with Phenytoin. |
Fosphenytoin Injection | Fosphenytoin Injection The serum concentration of Selumetinib can be decreased when it is combined with Fosphenytoin. |
Enfortumab vedotin-ejfv Injection | Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Selumetinib. |
Voxelotor | Voxelotor The metabolism of Voxelotor can be decreased when combined with Selumetinib. |
Avapritinib | Avapritinib The metabolism of Avapritinib can be decreased when combined with Selumetinib. |
Lasmiditan | Lasmiditan The serum concentration of Selumetinib can be increased when it is combined with Lasmiditan. |
Ubrogepant | Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Selumetinib. |
Tazemetostat | Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Selumetinib. |
Cenobamate | Cenobamate The serum concentration of Selumetinib can be decreased when it is combined with Cenobamate. |
Ozanimod | Ozanimod The metabolism of Ozanimod can be decreased when combined with Selumetinib. |
Rimegepant | Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Selumetinib. |
Tucatinib | Tucatinib Tucatinib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Remdesivir Injection | Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Selumetinib. |
Ripretinib | Ripretinib Ripretinib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Selpercatinib | Selpercatinib The serum concentration of Selumetinib can be increased when it is combined with Selpercatinib. |
Capmatinib | Capmatinib The serum concentration of Selumetinib can be increased when it is combined with Capmatinib. |
Lemborexant | Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Selumetinib. |
Fostemsavir | Fostemsavir Fostemsavir may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Belantamab Mafodotin-blmf Injection | Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Selumetinib. |
Pralsetinib | Pralsetinib Pralsetinib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Opicapone | Opicapone The metabolism of Selumetinib can be decreased when combined with Opicapone. |
Satralizumab-mwge Injection | Satralizumab-mwge Injection The serum concentration of Selumetinib can be decreased when it is combined with Satralizumab. |
Viloxazine | Viloxazine The metabolism of Selumetinib can be decreased when combined with Viloxazine. |
Vitamin E (Alpha-Tocopherol) | Vitamin E (Alpha-Tocopherol) The risk or severity of bleeding can be increased when Vitamin E is combined with Selumetinib. |
Theophylline | Theophylline The metabolism of Selumetinib can be decreased when combined with Theophylline. |
Indomethacin | Indomethacin The metabolism of Selumetinib can be decreased when combined with Indomethacin. |
Mefenamic Acid | Mefenamic Acid The metabolism of Selumetinib can be decreased when combined with Mefenamic acid. |
Naproxen | Naproxen The metabolism of Selumetinib can be decreased when combined with Naproxen. |
Trazodone | Trazodone The metabolism of Selumetinib can be decreased when combined with Trazodone. |
Floxuridine | Floxuridine The metabolism of Selumetinib can be decreased when combined with Floxuridine. |
Phenobarbital | Phenobarbital The serum concentration of Selumetinib can be decreased when it is combined with Phenobarbital. |
Primidone | Primidone The serum concentration of Selumetinib can be decreased when it is combined with Primidone. |
Methsuximide | Methsuximide The metabolism of Selumetinib can be decreased when combined with Methsuximide. |
Chlorpromazine | Chlorpromazine The metabolism of Selumetinib can be decreased when combined with Chlorpromazine. |
Diazepam | Diazepam The metabolism of Selumetinib can be decreased when combined with Diazepam. |
Flurazepam | Flurazepam The metabolism of Selumetinib can be decreased when combined with Flurazepam. |
Carmustine | Carmustine The metabolism of Selumetinib can be decreased when combined with Carmustine. |
Tranylcypromine | Tranylcypromine The metabolism of Selumetinib can be decreased when combined with Tranylcypromine. |
Phenelzine | Phenelzine The metabolism of Selumetinib can be decreased when combined with Phenelzine. |
Thioridazine | Thioridazine The metabolism of Selumetinib can be decreased when combined with Thioridazine. |
Trifluoperazine | Trifluoperazine The metabolism of Selumetinib can be decreased when combined with Trifluoperazine. |
Dapsone | Dapsone The metabolism of Selumetinib can be decreased when combined with Dapsone. |
Sulfadiazine | Sulfadiazine The metabolism of Selumetinib can be decreased when combined with Sulfadiazine. |
Oxycodone | Oxycodone The metabolism of Selumetinib can be decreased when combined with Oxycodone. |
Methadone | Methadone The metabolism of Selumetinib can be decreased when combined with Methadone. |
Oxybutynin | Oxybutynin The metabolism of Selumetinib can be decreased when combined with Oxybutynin. |
Maprotiline | Maprotiline The metabolism of Selumetinib can be decreased when combined with Maprotiline. |
Ibuprofen | Ibuprofen The metabolism of Selumetinib can be decreased when combined with Ibuprofen. |
Orphenadrine | Orphenadrine The metabolism of Selumetinib can be decreased when combined with Orphenadrine. |
Perphenazine | Perphenazine The metabolism of Selumetinib can be decreased when combined with Perphenazine. |
Azathioprine | Azathioprine The metabolism of Selumetinib can be decreased when combined with Azathioprine. |
Fluphenazine | Fluphenazine The metabolism of Selumetinib can be decreased when combined with Fluphenazine. |
Sulfasalazine | Sulfasalazine Sulfasalazine may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Hydrocortisone | Hydrocortisone The metabolism of Selumetinib can be increased when combined with Hydrocortisone. |
Dactinomycin | Dactinomycin The serum concentration of Selumetinib can be increased when it is combined with Dactinomycin. |
Carbamazepine | Carbamazepine The serum concentration of Selumetinib can be decreased when it is combined with Carbamazepine. |
Clonidine | Clonidine The metabolism of Selumetinib can be decreased when combined with Clonidine. |
Cimetidine | Cimetidine The metabolism of Selumetinib can be decreased when combined with Cimetidine. |
Warfarin | Warfarin The metabolism of Selumetinib can be decreased when combined with Warfarin. |
Clonazepam | Clonazepam The metabolism of Selumetinib can be decreased when combined with Clonazepam. |
Loperamide | Loperamide The serum concentration of Selumetinib can be increased when it is combined with Loperamide. |
Promethazine | Promethazine The metabolism of Selumetinib can be decreased when combined with Promethazine. |
Daunorubicin | Daunorubicin The metabolism of Selumetinib can be increased when combined with Daunorubicin. |
Griseofulvin | Griseofulvin The metabolism of Selumetinib can be increased when combined with Griseofulvin. |
Digoxin | Digoxin The serum concentration of Digoxin can be increased when it is combined with Selumetinib. |
Loxapine | Loxapine The serum concentration of Selumetinib can be increased when it is combined with Loxapine. |
Chloroquine | Chloroquine The metabolism of Selumetinib can be decreased when combined with Chloroquine. |
Quinine | Quinine The metabolism of Selumetinib can be decreased when combined with Quinine. |
Ethosuximide | Ethosuximide The metabolism of Selumetinib can be decreased when combined with Ethosuximide. |
Triamterene | Triamterene The metabolism of Selumetinib can be decreased when combined with Triamterene. |
Sulfinpyrazone | Sulfinpyrazone The metabolism of Selumetinib can be decreased when combined with Sulfinpyrazone. |
Clindamycin Injection | Clindamycin Injection The metabolism of Selumetinib can be decreased when combined with Clindamycin. |
Secobarbital | Secobarbital The metabolism of Selumetinib can be increased when combined with Secobarbital. |
Desipramine | Desipramine The metabolism of Selumetinib can be decreased when combined with Desipramine. |
Amitriptyline | Amitriptyline The metabolism of Selumetinib can be decreased when combined with Amitriptyline. |
Imipramine | Imipramine The metabolism of Selumetinib can be decreased when combined with Imipramine. |
Probenecid | Probenecid The metabolism of Selumetinib can be decreased when combined with Probenecid. |
Quinidine | Quinidine The metabolism of Selumetinib can be decreased when combined with Quinidine. |
Isoniazid | Isoniazid The serum concentration of Selumetinib can be increased when it is combined with Isoniazid. |
Rifampin | Rifampin The serum concentration of Selumetinib can be decreased when it is combined with Rifampicin. |
Disopyramide | Disopyramide The metabolism of Selumetinib can be decreased when combined with Disopyramide. |
Valproic Acid | Valproic Acid The metabolism of Selumetinib can be decreased when combined with Valproic acid. |
Tamoxifen | Tamoxifen The metabolism of Selumetinib can be decreased when combined with Tamoxifen. |
Levothyroxine | Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Selumetinib. |
Liothyronine | Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Selumetinib. |
Methimazole | Methimazole The serum concentration of Methimazole can be increased when it is combined with Selumetinib. |
Propylthiouracil | Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Selumetinib. |
Chlorpropamide | Chlorpropamide The metabolism of Selumetinib can be decreased when combined with Chlorpropamide. |
Tolbutamide | Tolbutamide The metabolism of Selumetinib can be decreased when combined with Tolbutamide. |
Tolazamide | Tolazamide The metabolism of Selumetinib can be decreased when combined with Tolazamide. |
Dextromethorphan | Dextromethorphan The metabolism of Selumetinib can be decreased when combined with Dextromethorphan. |
Cyclobenzaprine | Cyclobenzaprine The metabolism of Selumetinib can be decreased when combined with Cyclobenzaprine. |
Niacin | Niacin The metabolism of Selumetinib can be decreased when combined with Niacin. |
Chlorpheniramine | Chlorpheniramine The metabolism of Selumetinib can be decreased when combined with Chlorpheniramine. |
Chlorzoxazone | Chlorzoxazone The metabolism of Selumetinib can be decreased when combined with Chlorzoxazone. |
Carisoprodol | Carisoprodol The metabolism of Selumetinib can be decreased when combined with Carisoprodol. |
Danazol | Danazol The serum concentration of Selumetinib can be increased when it is combined with Danazol. |
Disulfiram | Disulfiram The metabolism of Selumetinib can be decreased when combined with Disulfiram. |
Propranolol (Cardiovascular) | Propranolol (Cardiovascular) The metabolism of Selumetinib can be decreased when combined with Propranolol. |
Nortriptyline | Nortriptyline The metabolism of Selumetinib can be decreased when combined with Nortriptyline. |
Spironolactone | Spironolactone The metabolism of Selumetinib can be decreased when combined with Spironolactone. |
Clomiphene | Clomiphene The serum concentration of Selumetinib can be increased when it is combined with Clomifene. |
Fluorouracil Injection | Fluorouracil Injection The metabolism of Selumetinib can be decreased when combined with Fluorouracil. |
Colchicine | Colchicine The metabolism of Selumetinib can be decreased when combined with Colchicine. |
Dacarbazine | Dacarbazine The metabolism of Selumetinib can be decreased when combined with Dacarbazine. |
Calcitonin Salmon Injection | Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Selumetinib. |
Ketoconazole | Ketoconazole The serum concentration of Selumetinib can be increased when it is combined with Ketoconazole. |
Vincristine Injection | Vincristine Injection The metabolism of Selumetinib can be decreased when combined with Vincristine. |
Vinblastine | Vinblastine The serum concentration of Selumetinib can be increased when it is combined with Vinblastine. |
Hydroxyzine | Hydroxyzine The metabolism of Selumetinib can be decreased when combined with Hydroxyzine. |
Thiothixene | Thiothixene The metabolism of Selumetinib can be decreased when combined with Thiothixene. |
Aspirin | Aspirin The metabolism of Selumetinib can be decreased when combined with Acetylsalicylic acid. |
Alprazolam | Alprazolam The metabolism of Selumetinib can be decreased when combined with Alprazolam. |
Triazolam | Triazolam The metabolism of Selumetinib can be decreased when combined with Triazolam. |
Trimethoprim | Trimethoprim The metabolism of Selumetinib can be decreased when combined with Trimethoprim. |
Diltiazem | Diltiazem The serum concentration of Selumetinib can be increased when it is combined with Diltiazem. |
Nifedipine | Nifedipine The metabolism of Selumetinib can be decreased when combined with Nifedipine. |
Timolol | Timolol The metabolism of Selumetinib can be decreased when combined with Timolol. |
Verapamil | Verapamil The serum concentration of Selumetinib can be increased when it is combined with Verapamil. |
Cisplatin Injection | Cisplatin Injection The metabolism of Selumetinib can be decreased when combined with Cisplatin. |
Piroxicam | Piroxicam The metabolism of Selumetinib can be decreased when combined with Piroxicam. |
Streptozocin | Streptozocin The metabolism of Selumetinib can be increased when combined with Streptozocin. |
Etoposide | Etoposide The metabolism of Selumetinib can be decreased when combined with Etoposide. |
Glyburide | Glyburide The metabolism of Selumetinib can be decreased when combined with Glyburide. |
Glipizide | Glipizide The metabolism of Selumetinib can be decreased when combined with Glipizide. |
Nafcillin Injection | Nafcillin Injection The serum concentration of Selumetinib can be decreased when it is combined with Nafcillin. |
Pentoxifylline | Pentoxifylline The metabolism of Selumetinib can be decreased when combined with Pentoxifylline. |
Pentamidine Injection | Pentamidine Injection The metabolism of Selumetinib can be decreased when combined with Pentamidine. |
Labetalol | Labetalol The metabolism of Selumetinib can be decreased when combined with Labetalol. |
Gemfibrozil | Gemfibrozil The metabolism of Selumetinib can be decreased when combined with Gemfibrozil. |
Guanabenz | Guanabenz The metabolism of Selumetinib can be decreased when combined with Guanabenz. |
Ketoprofen | Ketoprofen The metabolism of Selumetinib can be decreased when combined with Ketoprofen. |
Pimozide | Pimozide The metabolism of Selumetinib can be decreased when combined with Pimozide. |
Flurbiprofen | Flurbiprofen The metabolism of Selumetinib can be decreased when combined with Flurbiprofen. |
Amiodarone | Amiodarone The metabolism of Selumetinib can be decreased when combined with Amiodarone. |
Buspirone | Buspirone The metabolism of Selumetinib can be decreased when combined with Buspirone. |
Lovastatin | Lovastatin The serum concentration of Selumetinib can be increased when it is combined with Lovastatin. |
Ciprofloxacin | Ciprofloxacin The serum concentration of Selumetinib can be increased when it is combined with Ciprofloxacin. |
Diclofenac | Diclofenac The metabolism of Selumetinib can be decreased when combined with Diclofenac. |
Fluoxetine | Fluoxetine The metabolism of Selumetinib can be decreased when combined with Fluoxetine. |
Interferon Alfa-2b Injection | Interferon Alfa-2b Injection The metabolism of Selumetinib can be decreased when combined with Interferon alfa-2b. |
Clozapine | Clozapine The serum concentration of Selumetinib can be increased when it is combined with Clozapine. |
Idarubicin | Idarubicin The metabolism of Selumetinib can be decreased when combined with Idarubicin. |
Ofloxacin | Ofloxacin The metabolism of Selumetinib can be decreased when combined with Ofloxacin. |
Clarithromycin | Clarithromycin The serum concentration of Selumetinib can be increased when it is combined with Clarithromycin. |
Etodolac | Etodolac The metabolism of Selumetinib can be decreased when combined with Etodolac. |
Felodipine | Felodipine The metabolism of Selumetinib can be decreased when combined with Felodipine. |
Nabumetone | Nabumetone The metabolism of Selumetinib can be decreased when combined with Nabumetone. |
Pravastatin | Pravastatin Pravastatin may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Simvastatin | Simvastatin The serum concentration of Selumetinib can be increased when it is combined with Simvastatin. |
Teniposide Injection | Teniposide Injection The metabolism of Selumetinib can be decreased when combined with Teniposide. |
Itraconazole | Itraconazole The serum concentration of Selumetinib can be increased when it is combined with Itraconazole. |
Atovaquone | Atovaquone The metabolism of Selumetinib can be decreased when combined with Atovaquone. |
Rifabutin | Rifabutin The metabolism of Selumetinib can be increased when combined with Rifabutin. |
Bisoprolol | Bisoprolol The serum concentration of Selumetinib can be increased when it is combined with Bisoprolol. |
Zolpidem | Zolpidem The metabolism of Selumetinib can be decreased when combined with Zolpidem. |
Doxazosin | Doxazosin The metabolism of Selumetinib can be decreased when combined with Doxazosin. |
Isradipine | Isradipine The serum concentration of Selumetinib can be increased when it is combined with Isradipine. |
Omeprazole | Omeprazole Omeprazole may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
Cisapride | Cisapride The metabolism of Selumetinib can be decreased when combined with Cisapride. |
Fluvastatin | Fluvastatin The metabolism of Selumetinib can be decreased when combined with Fluvastatin. |
Venlafaxine | Venlafaxine Venlafaxine may increase the excretion rate of Selumetinib which could result in a lower serum level and potentially a reduction in efficacy. |
Fluvoxamine | Fluvoxamine The serum concentration of Selumetinib can be increased when it is combined with Fluvoxamine. |
Nefazodone | Nefazodone The serum concentration of Selumetinib can be increased when it is combined with Nefazodone. |
Lamotrigine | Lamotrigine The metabolism of Selumetinib can be increased when combined with Lamotrigine. |
Losartan | Losartan The metabolism of Selumetinib can be decreased when combined with Losartan. |
Lansoprazole | Lansoprazole The metabolism of Selumetinib can be decreased when combined with Lansoprazole. |
Ifosfamide Injection | Ifosfamide Injection The metabolism of Selumetinib can be decreased when combined with Ifosfamide. |
Nicardipine | Nicardipine The serum concentration of Selumetinib can be increased when it is combined with Nicardipine. |
Bupropion | Bupropion The metabolism of Selumetinib can be decreased when combined with Bupropion. |
Ticlopidine | Ticlopidine The metabolism of Selumetinib can be decreased when combined with Ticlopidine. |
Saquinavir | Saquinavir The serum concentration of Selumetinib can be increased when it is combined with Saquinavir. |
Nisoldipine | Nisoldipine The metabolism of Selumetinib can be decreased when combined with Nisoldipine. |
Riluzole | Riluzole The metabolism of Selumetinib can be decreased when combined with Riluzole. |
Glimepiride | Glimepiride The metabolism of Selumetinib can be decreased when combined with Glimepiride. |
Anastrozole | Anastrozole The metabolism of Selumetinib can be decreased when combined with Anastrozole. |
Gemcitabine Injection | Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Selumetinib. |
Indinavir | Indinavir The metabolism of Selumetinib can be decreased when combined with Indinavir. |
Ritonavir | Ritonavir The serum concentration of Selumetinib can be increased when it is combined with Ritonavir. |
Docetaxel Injection | Docetaxel Injection The metabolism of Selumetinib can be decreased when combined with Docetaxel. |
Clomipramine | Clomipramine The metabolism of Selumetinib can be decreased when combined with Clomipramine. |
Zafirlukast | Zafirlukast The metabolism of Selumetinib can be decreased when combined with Zafirlukast. |
Mirtazapine | Mirtazapine The metabolism of Selumetinib can be decreased when combined with Mirtazapine. |
Topiramate | Topiramate The metabolism of Selumetinib can be decreased when combined with Topiramate. |
Zileuton | Zileuton The metabolism of Selumetinib can be decreased when combined with Zileuton. |
Valsartan | Valsartan The metabolism of Selumetinib can be decreased when combined with Valsartan. |
Insulin Lispro Injection | Insulin Lispro Injection The metabolism of Selumetinib can be increased when combined with Insulin lispro. |
Donepezil | Donepezil The metabolism of Selumetinib can be decreased when combined with Donepezil. |
Nelfinavir | Nelfinavir The metabolism of Selumetinib can be decreased when combined with Nelfinavir. |
Fexofenadine | Fexofenadine The serum concentration of Selumetinib can be increased when it is combined with Fexofenadine. |
Loratadine | Loratadine The metabolism of Selumetinib can be decreased when combined with Loratadine. |
Carvedilol | Carvedilol The serum concentration of Selumetinib can be increased when it is combined with Carvedilol. |
Nilutamide | Nilutamide The metabolism of Selumetinib can be decreased when combined with Nilutamide. |
Flutamide | Flutamide The metabolism of Selumetinib can be decreased when combined with Flutamide. |
Selegiline | Selegiline The metabolism of Selumetinib can be decreased when combined with Selegiline. |
Bicalutamide | Bicalutamide The metabolism of Selumetinib can be decreased when combined with Bicalutamide. |
Sertraline | Sertraline The metabolism of Selumetinib can be decreased when combined with Sertraline. |
Propafenone | Propafenone The serum concentration of Selumetinib can be increased when it is combined with Propafenone. |
Letrozole | Letrozole The metabolism of Selumetinib can be decreased when combined with Letrozole. |
Raloxifene | Raloxifene The metabolism of Selumetinib can be decreased when combined with Raloxifene. |
Irbesartan | Irbesartan The metabolism of Selumetinib can be decreased when combined with Irbesartan. |
Finasteride | Finasteride The metabolism of Selumetinib can be decreased when combined with Finasteride. |
Quetiapine | Quetiapine The metabolism of Selumetinib can be decreased when combined with Quetiapine. |
Paroxetine | Paroxetine The metabolism of Selumetinib can be decreased when combined with Paroxetine. |
Tolcapone | Tolcapone The metabolism of Selumetinib can be decreased when combined with Tolcapone. |
Citalopram | Citalopram The metabolism of Selumetinib can be decreased when combined with Citalopram. |
Capecitabine | Capecitabine The metabolism of Selumetinib can be decreased when combined with Capecitabine. |
Efavirenz | Efavirenz The serum concentration of Selumetinib can be increased when it is combined with Efavirenz. |
Sildenafil | Sildenafil The serum concentration of Selumetinib can be increased when it is combined with Sildenafil. |
Pioglitazone | Pioglitazone The metabolism of Selumetinib can be decreased when combined with Pioglitazone. |
Celecoxib | Celecoxib The metabolism of Selumetinib can be decreased when combined with Celecoxib. |
Rosiglitazone | Rosiglitazone The metabolism of Selumetinib can be decreased when combined with Rosiglitazone. |
Tolterodine | Tolterodine The metabolism of Selumetinib can be decreased when combined with Tolterodine. |
Thalidomide | Thalidomide The metabolism of Selumetinib can be increased when combined with Thalidomide. |
Nateglinide | Nateglinide The metabolism of Selumetinib can be decreased when combined with Nateglinide. |
Rabeprazole | Rabeprazole The metabolism of Selumetinib can be decreased when combined with Rabeprazole. |
Terbinafine | Terbinafine The metabolism of Selumetinib can be decreased when combined with Terbinafine. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists