Selumetinib

Generic name: Pronounced as (sel" ue me' ti nib)
Brand names
  • Koselugo®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/15/2020

Selumetinib is used to treat neurofibromatosis type 1 (NF1; a nervous system disorder that causes tumors to grow on nerves) in children 2 years of age and older who have plexiform neurofibromas (PN; soft tumors) that cannot be completely removed by surgery. Selumetinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals the tumors to grow. This helps to stop or slow tumor growth.

Selumetinib comes as a capsule to take by mouth. It is usually taken twice a day on an empty stomach. Do not eat any food 2 hours before or for 1 hour after each dose. Take selumetinib at around the same time(s) every day, approximately 12 hours apart. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take selumetinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole with water; do not open, chew, or crush them.

If you vomit after taking selumetinib, do not take another dose. Continue your regular dosing schedule.

Your doctor may decrease your dose or temporarily or permanently stop your treatment if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with selumetinib.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking selumetinib,

  • tell your doctor and pharmacist if you are allergic to selumetinib, any other medications, or any of the ingredients in selumetinib capsules. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend); aprepitant (Emend); clarithromycin (Biaxin, in Prevpac); clopidogrel (Plavix); corticosteroids such as betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, Dexpak, Dexasone, others), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol, Meprolone, others), prednisolone (Prelone, others), and prednisone (Rayos); diltiazem (Cardizem, Dilacor, Tiazac, others); erythromycin (E.E.S., E-Mycin, Erythrocin); certain medications for HIV including indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Fortovase, Invirase); idelalisib (Zydelig); nefazodone; phenobarbital; rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); verapamil (Calan, Covera); and vitamin E supplements. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have or have ever had vision problems, difficulty swallowing, or heart or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or if you plan on fathering a child. If you are female, you will need to take a pregnancy test before you start treatment and use birth control to prevent pregnancy during your treatment and for at least 1 week after your final dose. If you are a male, you and your partner should use birth control during your treatment with selumetinib and for 1 week after your final dose. Talk to your doctor about birth control methods that you can use during your treatment. If you or your partner become pregnant while taking selumetinib, call your doctor immediately. Selumetinib may harm the fetus.

  • tell your doctor if you are breastfeeding. You should not breastfeed while you are taking selumetinib and for 1 week after the final dose.

Avoid eating grapefruit or drinking grapefruit juice while taking this medication.

Take the missed dose as soon as you remember it. However, if it is within 6 hours of the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Selumetinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • vomiting

    • constipation

    • stomach pain

    • nausea

    • dry skin

    • headache

    • mouth ulcers

    • itching

    • redness around the fingernails

    • nose bleeding

    • fatigue

    • loss of appetite

    • hair loss or hair color changes

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • fever

    • unusual bleeding

    • pale skin or tiredness

    • blurred vision; loss of vision; dark spots in your vision; or other vision changes

    • diarrhea

    • rash, skin blisters or peeling

    • muscle pain, aches, or weakness; or dark urine

    • coughing or wheezing; shortness of breath; swelling of ankles and feet; or extreme tiredness

  • Selumetinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not remove the desiccant (small packet included with the capsules to absorb moisture) from your bottle.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor, eye doctor, and the laboratory. Your doctor will order certain lab tests, including eye exams, before, during, and after your treatment to check your body's response to selumetinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The metabolism of Selumetinib can be decreased when combined with Moxifloxacin.
Repaglinide Repaglinide The metabolism of Selumetinib can be decreased when combined with Repaglinide.
Montelukast Montelukast The metabolism of Selumetinib can be decreased when combined with Montelukast.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The metabolism of Selumetinib can be increased when combined with Insulin glargine.
Leflunomide Leflunomide The serum concentration of Selumetinib can be decreased when it is combined with Leflunomide.
Delavirdine Delavirdine The serum concentration of Selumetinib can be increased when it is combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Selumetinib can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Selumetinib can be decreased when combined with Atorvastatin.
Aminophylline Aminophylline The metabolism of Selumetinib can be decreased when combined with Aminophylline.
Anagrelide Anagrelide The metabolism of Selumetinib can be decreased when combined with Anagrelide.
Candesartan Candesartan The metabolism of Selumetinib can be decreased when combined with Candesartan.
Cilostazol Cilostazol The metabolism of Selumetinib can be decreased when combined with Cilostazol.
Clopidogrel Clopidogrel The metabolism of Selumetinib can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Selumetinib can be increased when it is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Selumetinib can be decreased when combined with Conjugated estrogens.
Fenofibrate Fenofibrate The metabolism of Selumetinib can be decreased when combined with Fenofibrate.
Paregoric Paregoric The metabolism of Selumetinib can be decreased when combined with Morphine.
Ranitidine Ranitidine The metabolism of Selumetinib can be decreased when combined with Ranitidine.
Reserpine Reserpine The serum concentration of Selumetinib can be increased when it is combined with Reserpine.
Tacrolimus Tacrolimus The metabolism of Selumetinib can be decreased when combined with Tacrolimus.
Tizanidine Tizanidine The metabolism of Selumetinib can be decreased when combined with Tizanidine.
Triamcinolone Triamcinolone The metabolism of Selumetinib can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan The metabolism of Selumetinib can be decreased when combined with Zolmitriptan.
Famotidine Injection Famotidine Injection The metabolism of Selumetinib can be decreased when combined with Famotidine.
Fluconazole Injection Fluconazole Injection The serum concentration of Selumetinib can be increased when it is combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Selumetinib can be decreased when combined with Hydromorphone.
Interferon Beta-1b Injection Interferon Beta-1b Injection The metabolism of Selumetinib can be decreased when combined with Interferon beta-1b.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The metabolism of Selumetinib can be decreased when combined with Interferon gamma-1b.
Levofloxacin Injection Levofloxacin Injection The metabolism of Selumetinib can be decreased when combined with Levofloxacin.
Meperidine Injection Meperidine Injection The metabolism of Selumetinib can be increased when combined with Meperidine.
Metoclopramide Injection Metoclopramide Injection The metabolism of Selumetinib can be decreased when combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The metabolism of Selumetinib can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Selumetinib can be decreased when combined with Morphine.
Zidovudine Injection Zidovudine Injection The metabolism of Selumetinib can be increased when combined with Zidovudine.
Cyclosporine Cyclosporine The serum concentration of Selumetinib can be increased when it is combined with Cyclosporine.
Ondansetron Ondansetron The metabolism of Selumetinib can be decreased when combined with Ondansetron.
Torsemide Torsemide The metabolism of Selumetinib can be decreased when combined with Torasemide.
Olanzapine Olanzapine The metabolism of Selumetinib can be decreased when combined with Olanzapine.
Alosetron Alosetron The metabolism of Selumetinib can be decreased when combined with Alosetron.
Hydroxychloroquine Hydroxychloroquine The metabolism of Selumetinib can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam The metabolism of Selumetinib can be decreased when combined with Meloxicam.
Oxcarbazepine Oxcarbazepine The metabolism of Selumetinib can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Zaleplon Zaleplon The metabolism of Selumetinib can be decreased when combined with Zaleplon.
Anakinra Anakinra The metabolism of Selumetinib can be increased when combined with Anakinra.
Trimipramine Trimipramine The metabolism of Selumetinib can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Selumetinib can be increased when combined with Etanercept.
Modafinil Modafinil The serum concentration of Selumetinib can be decreased when it is combined with Modafinil.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Selumetinib.
Sirolimus Sirolimus The metabolism of Selumetinib can be decreased when combined with Sirolimus.
Dutasteride Dutasteride The metabolism of Selumetinib can be decreased when combined with Dutasteride.
Epinephrine Injection Epinephrine Injection The metabolism of Selumetinib can be decreased when combined with Epinephrine.
Eplerenone Eplerenone The metabolism of Selumetinib can be decreased when combined with Eplerenone.
Escitalopram Escitalopram The metabolism of Selumetinib can be decreased when combined with Escitalopram.
Zonisamide Zonisamide The serum concentration of Selumetinib can be increased when it is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Selumetinib can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Selumetinib can be decreased when combined with Aripiprazole.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Selumetinib.
Atazanavir Atazanavir The serum concentration of Selumetinib can be increased when it is combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Selumetinib can be decreased when combined with Almotriptan.
Eletriptan Eletriptan The metabolism of Selumetinib can be decreased when combined with Eletriptan.
Rosuvastatin Rosuvastatin The metabolism of Selumetinib can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil The serum concentration of Selumetinib can be increased when it is combined with Vardenafil.
Aprepitant Aprepitant The serum concentration of Selumetinib can be increased when it is combined with Aprepitant.
Interferon Beta-1a Subcutaneous Injection Interferon Beta-1a Subcutaneous Injection The metabolism of Selumetinib can be decreased when combined with Interferon beta-1a.
Memantine Memantine The metabolism of Selumetinib can be decreased when combined with Memantine.
Tegaserod Tegaserod The metabolism of Selumetinib can be decreased when combined with Tegaserod.
Tadalafil Tadalafil The metabolism of Selumetinib can be decreased when combined with Tadalafil.
Frovatriptan Frovatriptan The metabolism of Selumetinib can be decreased when combined with Frovatriptan.
Gemifloxacin Gemifloxacin The metabolism of Selumetinib can be decreased when combined with Gemifloxacin.
Progesterone Progesterone Progesterone may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Apomorphine Injection Apomorphine Injection The metabolism of Selumetinib can be decreased when combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Selumetinib can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Selumetinib can be decreased when combined with Oxandrolone.
Rifaximin Rifaximin The serum concentration of Selumetinib can be decreased when it is combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Selumetinib can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Selumetinib can be decreased when combined with Norethisterone.
Bosentan Bosentan The serum concentration of Selumetinib can be decreased when it is combined with Bosentan.
Cinacalcet Cinacalcet The metabolism of Selumetinib can be decreased when combined with Cinacalcet.
Erlotinib Erlotinib The metabolism of Selumetinib can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Selumetinib can be decreased when combined with Eszopiclone.
Voriconazole Voriconazole The serum concentration of Selumetinib can be increased when it is combined with Voriconazole.
Entecavir Entecavir The metabolism of Selumetinib can be decreased when combined with Entecavir.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The metabolism of Selumetinib can be decreased when combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Selumetinib can be increased when it is combined with Peginterferon alfa-2b.
Ramelteon Ramelteon The metabolism of Selumetinib can be decreased when combined with Ramelteon.
Fentanyl Fentanyl The metabolism of Selumetinib can be decreased when combined with Fentanyl.
Deferasirox Deferasirox The serum concentration of Selumetinib can be increased when it is combined with Deferasirox.
Phenylephrine Phenylephrine The metabolism of Selumetinib can be increased when combined with Phenylephrine.
Tipranavir Tipranavir The serum concentration of Selumetinib can be increased when it is combined with Tipranavir.
Felbamate Felbamate The metabolism of Selumetinib can be decreased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Selumetinib can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Selumetinib can be increased when combined with Abatacept.
Rasagiline Rasagiline The metabolism of Selumetinib can be decreased when combined with Rasagiline.
Imatinib Imatinib The metabolism of Selumetinib can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The metabolism of Selumetinib can be decreased when combined with Sitagliptin.
Gefitinib Gefitinib Gefitinib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Paliperidone Paliperidone The serum concentration of Selumetinib can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Selumetinib can be decreased when combined with Bortezomib.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The metabolism of Selumetinib can be increased when combined with Insulin glulisine.
Posaconazole Posaconazole The serum concentration of Selumetinib can be increased when it is combined with Posaconazole.
Primaquine Primaquine The serum concentration of Selumetinib can be increased when it is combined with Primaquine.
Darunavir Darunavir The serum concentration of Selumetinib can be increased when it is combined with Darunavir.
Pemetrexed Injection Pemetrexed Injection The metabolism of Selumetinib can be decreased when combined with Pemetrexed.
Nabilone Nabilone The metabolism of Selumetinib can be decreased when combined with Nabilone.
Sorafenib Sorafenib The metabolism of Selumetinib can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Selumetinib can be decreased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Lapatinib Lapatinib The serum concentration of Selumetinib can be increased when it is combined with Lapatinib.
Dasatinib Dasatinib The metabolism of Selumetinib can be decreased when combined with Dasatinib.
Mexiletine Mexiletine The metabolism of Selumetinib can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Selumetinib can be decreased when combined with Armodafinil.
Temsirolimus Temsirolimus The metabolism of Selumetinib can be decreased when combined with Temsirolimus.
Nilotinib Nilotinib The serum concentration of Selumetinib can be increased when it is combined with Nilotinib.
Toremifene Toremifene The serum concentration of Selumetinib can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The serum concentration of Selumetinib can be decreased when it is combined with Bexarotene.
Budesonide Budesonide The metabolism of Selumetinib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Selumetinib can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The serum concentration of Selumetinib can be decreased when it is combined with Etravirine.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Selumetinib can be increased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The serum concentration of Selumetinib can be increased when it is combined with Desvenlafaxine.
Nebivolol Nebivolol The metabolism of Selumetinib can be decreased when combined with Nebivolol.
Tretinoin Tretinoin The metabolism of Selumetinib can be decreased when combined with Tretinoin.
Bendamustine Injection Bendamustine Injection The metabolism of Selumetinib can be decreased when combined with Bendamustine.
Flecainide Flecainide The metabolism of Selumetinib can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Selumetinib can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection The metabolism of Selumetinib can be decreased when combined with Irinotecan.
Praziquantel Praziquantel The metabolism of Selumetinib can be decreased when combined with Praziquantel.
Mitotane Mitotane The serum concentration of Selumetinib can be decreased when it is combined with Mitotane.
Rufinamide Rufinamide The metabolism of Selumetinib can be decreased when combined with Rufinamide.
Silodosin Silodosin The serum concentration of Selumetinib can be increased when it is combined with Silodosin.
Midazolam Midazolam The metabolism of Selumetinib can be decreased when combined with Midazolam.
Eltrombopag Eltrombopag The metabolism of Selumetinib can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The serum concentration of Selumetinib can be increased when it is combined with Milnacipran.
Dexlansoprazole Dexlansoprazole The metabolism of Selumetinib can be decreased when combined with Dexlansoprazole.
Betaxolol Betaxolol The metabolism of Selumetinib can be decreased when combined with Betaxolol.
Iloperidone Iloperidone The metabolism of Selumetinib can be decreased when combined with Iloperidone.
Prasugrel Prasugrel The metabolism of Selumetinib can be decreased when combined with Prasugrel.
Lacosamide Lacosamide The metabolism of Selumetinib can be decreased when combined with Lacosamide.
Everolimus Everolimus The serum concentration of Selumetinib can be increased when it is combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Selumetinib can be increased when it is combined with Tolvaptan.
Dronedarone Dronedarone The serum concentration of Selumetinib can be increased when it is combined with Dronedarone.
Saxagliptin Saxagliptin The metabolism of Selumetinib can be decreased when combined with Saxagliptin.
Romidepsin Injection Romidepsin Injection The serum concentration of Selumetinib can be increased when it is combined with Romidepsin.
Tapentadol Tapentadol The metabolism of Selumetinib can be decreased when combined with Tapentadol.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Selumetinib.
Golimumab Injection Golimumab Injection The metabolism of Selumetinib can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Selumetinib can be decreased when combined with Pazopanib.
Asenapine Asenapine The metabolism of Selumetinib can be decreased when combined with Asenapine.
Pitavastatin Pitavastatin The metabolism of Selumetinib can be decreased when combined with Pitavastatin.
Albendazole Albendazole The metabolism of Selumetinib can be decreased when combined with Albendazole.
Levonorgestrel Levonorgestrel The metabolism of Selumetinib can be decreased when combined with Levonorgestrel.
Tocilizumab Injection Tocilizumab Injection The metabolism of Selumetinib can be increased when combined with Tocilizumab.
Fingolimod Fingolimod The metabolism of Selumetinib can be decreased when combined with Fingolimod.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Selumetinib can be decreased when combined with Cabazitaxel.
Acetaminophen Injection Acetaminophen Injection Selumetinib may increase the hepatotoxic activities of Acetaminophen.
Vilazodone Vilazodone The metabolism of Selumetinib can be decreased when combined with Vilazodone.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Selumetinib can be decreased when combined with Aldesleukin.
Linagliptin Linagliptin The serum concentration of Selumetinib can be increased when it is combined with Linagliptin.
Rilpivirine Rilpivirine Rilpivirine may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Telaprevir Telaprevir Glecaprevir may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Selumetinib.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Selumetinib can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The serum concentration of Selumetinib can be increased when it is combined with Abiraterone.
Rivaroxaban Rivaroxaban The serum concentration of Selumetinib can be increased when it is combined with Rivaroxaban.
Ticagrelor Ticagrelor The serum concentration of Selumetinib can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Selumetinib.
Vandetanib Vandetanib Vandetanib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Clobazam Clobazam The metabolism of Selumetinib can be decreased when combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Selumetinib can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Ivacaftor Ivacaftor The serum concentration of Selumetinib can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The metabolism of Selumetinib can be decreased when combined with Axitinib.
Crizotinib Crizotinib The serum concentration of Selumetinib can be increased when it is combined with Crizotinib.
Cabergoline Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Selumetinib.
Naloxone Injection Naloxone Injection The serum concentration of Selumetinib can be increased when it is combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Selumetinib can be increased when it is combined with Ambrisentan.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Selumetinib can be increased when it is combined with Carfilzomib.
Enzalutamide Enzalutamide The serum concentration of Selumetinib can be decreased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Selumetinib can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib Regorafenib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Bosutinib Bosutinib The metabolism of Selumetinib can be decreased when combined with Bosutinib.
Teriflunomide Teriflunomide The serum concentration of Selumetinib can be decreased when it is combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Selumetinib can be decreased when combined with Cabozantinib.
Ponatinib Ponatinib The metabolism of Selumetinib can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide The metabolism of Selumetinib can be decreased when combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Selumetinib can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The metabolism of Selumetinib can be decreased when combined with Apixaban.
Canagliflozin Canagliflozin The serum concentration of Selumetinib can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The serum concentration of Selumetinib can be decreased when it is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Selumetinib can be decreased when combined with Ospemifene.
Trametinib Trametinib The metabolism of Selumetinib can be decreased when combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Selumetinib can be increased when it is combined with Dolutegravir.
Afatinib Afatinib Afatinib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The metabolism of Selumetinib can be decreased when combined with Levomilnacipran.
Vortioxetine Vortioxetine The metabolism of Selumetinib can be decreased when combined with Vortioxetine.
Perampanel Perampanel The metabolism of Selumetinib can be decreased when combined with Perampanel.
Ibrutinib Ibrutinib The metabolism of Selumetinib can be decreased when combined with Ibrutinib.
Lomitapide Lomitapide The serum concentration of Selumetinib can be increased when it is combined with Lomitapide.
Ketorolac Injection Ketorolac Injection The metabolism of Selumetinib can be decreased when combined with Ketorolac.
Simeprevir Simeprevir The serum concentration of Selumetinib can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Selumetinib can be increased when it is combined with Sofosbuvir.
Dapagliflozin Dapagliflozin The metabolism of Selumetinib can be decreased when combined with Dapagliflozin.
Apremilast Apremilast The metabolism of Selumetinib can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Selumetinib can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Selumetinib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Selumetinib can be decreased when combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The serum concentration of Selumetinib can be increased when it is combined with Belinostat.
Idelalisib Idelalisib The serum concentration of Selumetinib can be increased when it is combined with Idelalisib.
Testosterone Injection Testosterone Injection The metabolism of Selumetinib can be decreased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Selumetinib can be decreased when combined with Oritavancin.
Vorapaxar Vorapaxar The serum concentration of Selumetinib can be increased when it is combined with Vorapaxar.
Suvorexant Suvorexant The serum concentration of Selumetinib can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Selumetinib can be increased when it is combined with Edoxaban.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The metabolism of Selumetinib can be decreased when combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Selumetinib can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Selumetinib can be decreased when combined with Tasimelteon.
Riociguat Riociguat The metabolism of Selumetinib can be decreased when combined with Riociguat.
Pirfenidone Pirfenidone The metabolism of Selumetinib can be decreased when combined with Pirfenidone.
Nintedanib Nintedanib The serum concentration of Selumetinib can be increased when it is combined with Nintedanib.
Secukinumab Injection Secukinumab Injection The metabolism of Selumetinib can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Selumetinib can be decreased when combined with Risperidone.
Palbociclib Palbociclib Palbociclib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Insulin Human Inhalation Insulin Human Inhalation The metabolism of Selumetinib can be increased when combined with Insulin human.
Lenvatinib Lenvatinib The metabolism of Selumetinib can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Selumetinib can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The serum concentration of Selumetinib can be increased when it is combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The serum concentration of Selumetinib can be increased when it is combined with Haloperidol.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Selumetinib can be increased when it is combined with Isavuconazonium.
Flibanserin Flibanserin The serum concentration of Selumetinib can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant Rolapitant may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Daclatasvir Daclatasvir Daclatasvir may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Ziprasidone Injection Ziprasidone Injection The serum concentration of Selumetinib can be increased when it is combined with Ziprasidone.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The metabolism of Selumetinib can be increased when combined with Insulin degludec.
Cobimetinib Cobimetinib The serum concentration of Selumetinib can be increased when it is combined with Cobimetinib.
Trabectedin Injection Trabectedin Injection The metabolism of Selumetinib can be decreased when combined with Trabectedin.
Osimertinib Osimertinib The serum concentration of Selumetinib can be decreased when it is combined with Osimertinib.
Alectinib Alectinib Alectinib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Selumetinib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Selumetinib can be decreased when combined with Lesinurad.
Dexamethasone Injection Dexamethasone Injection The serum concentration of Selumetinib can be decreased when it is combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The metabolism of Selumetinib can be decreased when combined with Brivaracetam.
Venetoclax Venetoclax The serum concentration of Selumetinib can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Selumetinib can be increased when it is combined with Cobicistat.
Selexipag Selexipag The metabolism of Selumetinib can be decreased when combined with Selexipag.
Obeticholic Acid Obeticholic Acid The metabolism of Selumetinib can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Selumetinib can be decreased when combined with Diphenhydramine.
Rucaparib Rucaparib Rucaparib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Ribociclib Ribociclib The serum concentration of Selumetinib can be increased when it is combined with Ribociclib.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Selumetinib.
Brigatinib Brigatinib The metabolism of Selumetinib can be decreased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Selumetinib can be decreased when combined with Doxepin.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Selumetinib.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Selumetinib.
Deflazacort Deflazacort The metabolism of Selumetinib can be increased when combined with Deflazacort.
Safinamide Safinamide Safinamide may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Midostaurin Midostaurin The serum concentration of Selumetinib can be increased when it is combined with Midostaurin.
Neratinib Neratinib The serum concentration of Selumetinib can be increased when it is combined with Neratinib.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Selumetinib.
Enasidenib Enasidenib The metabolism of Selumetinib can be decreased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Selumetinib can be increased when it is combined with Inotuzumab ozogamicin.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Selumetinib.
Delafloxacin Delafloxacin The metabolism of Selumetinib can be increased when combined with Delafloxacin.
Abemaciclib Abemaciclib Abemaciclib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Selumetinib.
Acalabrutinib Acalabrutinib The metabolism of Selumetinib can be decreased when combined with Acalabrutinib.
Letermovir Letermovir Letermovir may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Ertugliflozin Ertugliflozin The metabolism of Selumetinib can be decreased when combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection Buprenorphine may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Apalutamide Apalutamide The serum concentration of Selumetinib can be decreased when it is combined with Apalutamide.
Fostamatinib Fostamatinib Fostamatinib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Baricitinib Baricitinib Baricitinib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Lofexidine Lofexidine The metabolism of Selumetinib can be decreased when combined with Lofexidine.
Eliglustat Eliglustat The serum concentration of Selumetinib can be increased when it is combined with Eliglustat.
Binimetinib Binimetinib The metabolism of Binimetinib can be decreased when combined with Selumetinib.
Ivosidenib Ivosidenib The serum concentration of Selumetinib can be increased when it is combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Selumetinib.
Elagolix Elagolix The serum concentration of Selumetinib can be increased when it is combined with Elagolix.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Selumetinib.
Cannabidiol Cannabidiol Cannabidiol may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Dacomitinib Dacomitinib The metabolism of Selumetinib can be decreased when combined with Dacomitinib.
Duvelisib Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Selumetinib.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Selumetinib.
Sarecycline Sarecycline The serum concentration of Selumetinib can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The serum concentration of Selumetinib can be increased when it is combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Selumetinib.
Gilteritinib Gilteritinib Gilteritinib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Glasdegib Glasdegib Glasdegib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Selumetinib.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Selumetinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Selumetinib can be decreased when combined with Paclitaxel.
Rifamycin Rifamycin The serum concentration of Selumetinib can be decreased when it is combined with Rifamycin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Selumetinib can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Selumetinib.
Acyclovir Ophthalmic Acyclovir Ophthalmic The metabolism of Selumetinib can be decreased when combined with Acyclovir.
Erdafitinib Erdafitinib The serum concentration of Selumetinib can be increased when it is combined with Erdafitinib.
Esomeprazole Injection Esomeprazole Injection The metabolism of Selumetinib can be decreased when combined with Esomeprazole.
Alpelisib Alpelisib The serum concentration of Selumetinib can be decreased when it is combined with Alpelisib.
Darolutamide Darolutamide The serum concentration of Selumetinib can be increased when it is combined with Darolutamide.
Triclabendazole Triclabendazole The metabolism of Selumetinib can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The serum concentration of Selumetinib can be increased when it is combined with Entrectinib.
Pexidartinib Pexidartinib The metabolism of Selumetinib can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline Istradefylline may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Pitolisant Pitolisant The serum concentration of Selumetinib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib Fedratinib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Selumetinib.
Phenytoin Injection Phenytoin Injection The serum concentration of Selumetinib can be decreased when it is combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Selumetinib can be decreased when it is combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Selumetinib.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Selumetinib.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Selumetinib.
Lasmiditan Lasmiditan The serum concentration of Selumetinib can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Selumetinib.
Tazemetostat Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Selumetinib.
Cenobamate Cenobamate The serum concentration of Selumetinib can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Selumetinib.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Selumetinib.
Tucatinib Tucatinib Tucatinib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Selumetinib.
Ripretinib Ripretinib Ripretinib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Selpercatinib Selpercatinib The serum concentration of Selumetinib can be increased when it is combined with Selpercatinib.
Capmatinib Capmatinib The serum concentration of Selumetinib can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Selumetinib.
Fostemsavir Fostemsavir Fostemsavir may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Selumetinib.
Pralsetinib Pralsetinib Pralsetinib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Opicapone Opicapone The metabolism of Selumetinib can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Selumetinib can be decreased when it is combined with Satralizumab.
Viloxazine Viloxazine The metabolism of Selumetinib can be decreased when combined with Viloxazine.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The risk or severity of bleeding can be increased when Vitamin E is combined with Selumetinib.
Theophylline Theophylline The metabolism of Selumetinib can be decreased when combined with Theophylline.
Indomethacin Indomethacin The metabolism of Selumetinib can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The metabolism of Selumetinib can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Selumetinib can be decreased when combined with Naproxen.
Trazodone Trazodone The metabolism of Selumetinib can be decreased when combined with Trazodone.
Floxuridine Floxuridine The metabolism of Selumetinib can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The serum concentration of Selumetinib can be decreased when it is combined with Phenobarbital.
Primidone Primidone The serum concentration of Selumetinib can be decreased when it is combined with Primidone.
Methsuximide Methsuximide The metabolism of Selumetinib can be decreased when combined with Methsuximide.
Chlorpromazine Chlorpromazine The metabolism of Selumetinib can be decreased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Selumetinib can be decreased when combined with Diazepam.
Flurazepam Flurazepam The metabolism of Selumetinib can be decreased when combined with Flurazepam.
Carmustine Carmustine The metabolism of Selumetinib can be decreased when combined with Carmustine.
Tranylcypromine Tranylcypromine The metabolism of Selumetinib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Selumetinib can be decreased when combined with Phenelzine.
Thioridazine Thioridazine The metabolism of Selumetinib can be decreased when combined with Thioridazine.
Trifluoperazine Trifluoperazine The metabolism of Selumetinib can be decreased when combined with Trifluoperazine.
Dapsone Dapsone The metabolism of Selumetinib can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Selumetinib can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone The metabolism of Selumetinib can be decreased when combined with Oxycodone.
Methadone Methadone The metabolism of Selumetinib can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Selumetinib can be decreased when combined with Oxybutynin.
Maprotiline Maprotiline The metabolism of Selumetinib can be decreased when combined with Maprotiline.
Ibuprofen Ibuprofen The metabolism of Selumetinib can be decreased when combined with Ibuprofen.
Orphenadrine Orphenadrine The metabolism of Selumetinib can be decreased when combined with Orphenadrine.
Perphenazine Perphenazine The metabolism of Selumetinib can be decreased when combined with Perphenazine.
Azathioprine Azathioprine The metabolism of Selumetinib can be decreased when combined with Azathioprine.
Fluphenazine Fluphenazine The metabolism of Selumetinib can be decreased when combined with Fluphenazine.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Selumetinib can be increased when combined with Hydrocortisone.
Dactinomycin Dactinomycin The serum concentration of Selumetinib can be increased when it is combined with Dactinomycin.
Carbamazepine Carbamazepine The serum concentration of Selumetinib can be decreased when it is combined with Carbamazepine.
Clonidine Clonidine The metabolism of Selumetinib can be decreased when combined with Clonidine.
Cimetidine Cimetidine The metabolism of Selumetinib can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Selumetinib can be decreased when combined with Warfarin.
Clonazepam Clonazepam The metabolism of Selumetinib can be decreased when combined with Clonazepam.
Loperamide Loperamide The serum concentration of Selumetinib can be increased when it is combined with Loperamide.
Promethazine Promethazine The metabolism of Selumetinib can be decreased when combined with Promethazine.
Daunorubicin Daunorubicin The metabolism of Selumetinib can be increased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Selumetinib can be increased when combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Selumetinib.
Loxapine Loxapine The serum concentration of Selumetinib can be increased when it is combined with Loxapine.
Chloroquine Chloroquine The metabolism of Selumetinib can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Selumetinib can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The metabolism of Selumetinib can be decreased when combined with Ethosuximide.
Triamterene Triamterene The metabolism of Selumetinib can be decreased when combined with Triamterene.
Sulfinpyrazone Sulfinpyrazone The metabolism of Selumetinib can be decreased when combined with Sulfinpyrazone.
Clindamycin Injection Clindamycin Injection The metabolism of Selumetinib can be decreased when combined with Clindamycin.
Secobarbital Secobarbital The metabolism of Selumetinib can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Selumetinib can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The metabolism of Selumetinib can be decreased when combined with Amitriptyline.
Imipramine Imipramine The metabolism of Selumetinib can be decreased when combined with Imipramine.
Probenecid Probenecid The metabolism of Selumetinib can be decreased when combined with Probenecid.
Quinidine Quinidine The metabolism of Selumetinib can be decreased when combined with Quinidine.
Isoniazid Isoniazid The serum concentration of Selumetinib can be increased when it is combined with Isoniazid.
Rifampin Rifampin The serum concentration of Selumetinib can be decreased when it is combined with Rifampicin.
Disopyramide Disopyramide The metabolism of Selumetinib can be decreased when combined with Disopyramide.
Valproic Acid Valproic Acid The metabolism of Selumetinib can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Selumetinib can be decreased when combined with Tamoxifen.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Selumetinib.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Selumetinib.
Methimazole Methimazole The serum concentration of Methimazole can be increased when it is combined with Selumetinib.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Selumetinib.
Chlorpropamide Chlorpropamide The metabolism of Selumetinib can be decreased when combined with Chlorpropamide.
Tolbutamide Tolbutamide The metabolism of Selumetinib can be decreased when combined with Tolbutamide.
Tolazamide Tolazamide The metabolism of Selumetinib can be decreased when combined with Tolazamide.
Dextromethorphan Dextromethorphan The metabolism of Selumetinib can be decreased when combined with Dextromethorphan.
Cyclobenzaprine Cyclobenzaprine The metabolism of Selumetinib can be decreased when combined with Cyclobenzaprine.
Niacin Niacin The metabolism of Selumetinib can be decreased when combined with Niacin.
Chlorpheniramine Chlorpheniramine The metabolism of Selumetinib can be decreased when combined with Chlorpheniramine.
Chlorzoxazone Chlorzoxazone The metabolism of Selumetinib can be decreased when combined with Chlorzoxazone.
Carisoprodol Carisoprodol The metabolism of Selumetinib can be decreased when combined with Carisoprodol.
Danazol Danazol The serum concentration of Selumetinib can be increased when it is combined with Danazol.
Disulfiram Disulfiram The metabolism of Selumetinib can be decreased when combined with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Selumetinib can be decreased when combined with Propranolol.
Nortriptyline Nortriptyline The metabolism of Selumetinib can be decreased when combined with Nortriptyline.
Spironolactone Spironolactone The metabolism of Selumetinib can be decreased when combined with Spironolactone.
Clomiphene Clomiphene The serum concentration of Selumetinib can be increased when it is combined with Clomifene.
Fluorouracil Injection Fluorouracil Injection The metabolism of Selumetinib can be decreased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Selumetinib can be decreased when combined with Colchicine.
Dacarbazine Dacarbazine The metabolism of Selumetinib can be decreased when combined with Dacarbazine.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Selumetinib.
Ketoconazole Ketoconazole The serum concentration of Selumetinib can be increased when it is combined with Ketoconazole.
Vincristine Injection Vincristine Injection The metabolism of Selumetinib can be decreased when combined with Vincristine.
Vinblastine Vinblastine The serum concentration of Selumetinib can be increased when it is combined with Vinblastine.
Hydroxyzine Hydroxyzine The metabolism of Selumetinib can be decreased when combined with Hydroxyzine.
Thiothixene Thiothixene The metabolism of Selumetinib can be decreased when combined with Thiothixene.
Aspirin Aspirin The metabolism of Selumetinib can be decreased when combined with Acetylsalicylic acid.
Alprazolam Alprazolam The metabolism of Selumetinib can be decreased when combined with Alprazolam.
Triazolam Triazolam The metabolism of Selumetinib can be decreased when combined with Triazolam.
Trimethoprim Trimethoprim The metabolism of Selumetinib can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The serum concentration of Selumetinib can be increased when it is combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Selumetinib can be decreased when combined with Nifedipine.
Timolol Timolol The metabolism of Selumetinib can be decreased when combined with Timolol.
Verapamil Verapamil The serum concentration of Selumetinib can be increased when it is combined with Verapamil.
Cisplatin Injection Cisplatin Injection The metabolism of Selumetinib can be decreased when combined with Cisplatin.
Piroxicam Piroxicam The metabolism of Selumetinib can be decreased when combined with Piroxicam.
Streptozocin Streptozocin The metabolism of Selumetinib can be increased when combined with Streptozocin.
Etoposide Etoposide The metabolism of Selumetinib can be decreased when combined with Etoposide.
Glyburide Glyburide The metabolism of Selumetinib can be decreased when combined with Glyburide.
Glipizide Glipizide The metabolism of Selumetinib can be decreased when combined with Glipizide.
Nafcillin Injection Nafcillin Injection The serum concentration of Selumetinib can be decreased when it is combined with Nafcillin.
Pentoxifylline Pentoxifylline The metabolism of Selumetinib can be decreased when combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection The metabolism of Selumetinib can be decreased when combined with Pentamidine.
Labetalol Labetalol The metabolism of Selumetinib can be decreased when combined with Labetalol.
Gemfibrozil Gemfibrozil The metabolism of Selumetinib can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The metabolism of Selumetinib can be decreased when combined with Guanabenz.
Ketoprofen Ketoprofen The metabolism of Selumetinib can be decreased when combined with Ketoprofen.
Pimozide Pimozide The metabolism of Selumetinib can be decreased when combined with Pimozide.
Flurbiprofen Flurbiprofen The metabolism of Selumetinib can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Selumetinib can be decreased when combined with Amiodarone.
Buspirone Buspirone The metabolism of Selumetinib can be decreased when combined with Buspirone.
Lovastatin Lovastatin The serum concentration of Selumetinib can be increased when it is combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The serum concentration of Selumetinib can be increased when it is combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Selumetinib can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The metabolism of Selumetinib can be decreased when combined with Fluoxetine.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The metabolism of Selumetinib can be decreased when combined with Interferon alfa-2b.
Clozapine Clozapine The serum concentration of Selumetinib can be increased when it is combined with Clozapine.
Idarubicin Idarubicin The metabolism of Selumetinib can be decreased when combined with Idarubicin.
Ofloxacin Ofloxacin The metabolism of Selumetinib can be decreased when combined with Ofloxacin.
Clarithromycin Clarithromycin The serum concentration of Selumetinib can be increased when it is combined with Clarithromycin.
Etodolac Etodolac The metabolism of Selumetinib can be decreased when combined with Etodolac.
Felodipine Felodipine The metabolism of Selumetinib can be decreased when combined with Felodipine.
Nabumetone Nabumetone The metabolism of Selumetinib can be decreased when combined with Nabumetone.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Simvastatin Simvastatin The serum concentration of Selumetinib can be increased when it is combined with Simvastatin.
Teniposide Injection Teniposide Injection The metabolism of Selumetinib can be decreased when combined with Teniposide.
Itraconazole Itraconazole The serum concentration of Selumetinib can be increased when it is combined with Itraconazole.
Atovaquone Atovaquone The metabolism of Selumetinib can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Selumetinib can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol The serum concentration of Selumetinib can be increased when it is combined with Bisoprolol.
Zolpidem Zolpidem The metabolism of Selumetinib can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The metabolism of Selumetinib can be decreased when combined with Doxazosin.
Isradipine Isradipine The serum concentration of Selumetinib can be increased when it is combined with Isradipine.
Omeprazole Omeprazole Omeprazole may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Cisapride Cisapride The metabolism of Selumetinib can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Selumetinib can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may increase the excretion rate of Selumetinib which could result in a lower serum level and potentially a reduction in efficacy.
Fluvoxamine Fluvoxamine The serum concentration of Selumetinib can be increased when it is combined with Fluvoxamine.
Nefazodone Nefazodone The serum concentration of Selumetinib can be increased when it is combined with Nefazodone.
Lamotrigine Lamotrigine The metabolism of Selumetinib can be increased when combined with Lamotrigine.
Losartan Losartan The metabolism of Selumetinib can be decreased when combined with Losartan.
Lansoprazole Lansoprazole The metabolism of Selumetinib can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Selumetinib can be decreased when combined with Ifosfamide.
Nicardipine Nicardipine The serum concentration of Selumetinib can be increased when it is combined with Nicardipine.
Bupropion Bupropion The metabolism of Selumetinib can be decreased when combined with Bupropion.
Ticlopidine Ticlopidine The metabolism of Selumetinib can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The serum concentration of Selumetinib can be increased when it is combined with Saquinavir.
Nisoldipine Nisoldipine The metabolism of Selumetinib can be decreased when combined with Nisoldipine.
Riluzole Riluzole The metabolism of Selumetinib can be decreased when combined with Riluzole.
Glimepiride Glimepiride The metabolism of Selumetinib can be decreased when combined with Glimepiride.
Anastrozole Anastrozole The metabolism of Selumetinib can be decreased when combined with Anastrozole.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Selumetinib.
Indinavir Indinavir The metabolism of Selumetinib can be decreased when combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Selumetinib can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Selumetinib can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Selumetinib can be decreased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Selumetinib can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Selumetinib can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Selumetinib can be decreased when combined with Topiramate.
Zileuton Zileuton The metabolism of Selumetinib can be decreased when combined with Zileuton.
Valsartan Valsartan The metabolism of Selumetinib can be decreased when combined with Valsartan.
Insulin Lispro Injection Insulin Lispro Injection The metabolism of Selumetinib can be increased when combined with Insulin lispro.
Donepezil Donepezil The metabolism of Selumetinib can be decreased when combined with Donepezil.
Nelfinavir Nelfinavir The metabolism of Selumetinib can be decreased when combined with Nelfinavir.
Fexofenadine Fexofenadine The serum concentration of Selumetinib can be increased when it is combined with Fexofenadine.
Loratadine Loratadine The metabolism of Selumetinib can be decreased when combined with Loratadine.
Carvedilol Carvedilol The serum concentration of Selumetinib can be increased when it is combined with Carvedilol.
Nilutamide Nilutamide The metabolism of Selumetinib can be decreased when combined with Nilutamide.
Flutamide Flutamide The metabolism of Selumetinib can be decreased when combined with Flutamide.
Selegiline Selegiline The metabolism of Selumetinib can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Selumetinib can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Selumetinib can be decreased when combined with Sertraline.
Propafenone Propafenone The serum concentration of Selumetinib can be increased when it is combined with Propafenone.
Letrozole Letrozole The metabolism of Selumetinib can be decreased when combined with Letrozole.
Raloxifene Raloxifene The metabolism of Selumetinib can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Selumetinib can be decreased when combined with Irbesartan.
Finasteride Finasteride The metabolism of Selumetinib can be decreased when combined with Finasteride.
Quetiapine Quetiapine The metabolism of Selumetinib can be decreased when combined with Quetiapine.
Paroxetine Paroxetine The metabolism of Selumetinib can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Selumetinib can be decreased when combined with Tolcapone.
Citalopram Citalopram The metabolism of Selumetinib can be decreased when combined with Citalopram.
Capecitabine Capecitabine The metabolism of Selumetinib can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The serum concentration of Selumetinib can be increased when it is combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Selumetinib can be increased when it is combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Selumetinib can be decreased when combined with Pioglitazone.
Celecoxib Celecoxib The metabolism of Selumetinib can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Selumetinib can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The metabolism of Selumetinib can be decreased when combined with Tolterodine.
Thalidomide Thalidomide The metabolism of Selumetinib can be increased when combined with Thalidomide.
Nateglinide Nateglinide The metabolism of Selumetinib can be decreased when combined with Nateglinide.
Rabeprazole Rabeprazole The metabolism of Selumetinib can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Selumetinib can be decreased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists