Simvastatin

Generic name: Pronounced as (sim' va stat in)
Brand names
  • Flolipid®
  • Zocor®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2020

[Posted 07/20/2021]

AUDIENCE: Patient, Health Professional, OBGYN, Cardiology, Endocrinology, Pharmacy

ISSUE: The FDA is requesting revisions to the information about use in pregnancy in the prescribing information of the entire class of statin medicines. These changes include removing the contraindication against using these medicines in all pregnant patients. A contraindication is FDA's strongest warning and is only added when a medicine should not be used because the risk clearly outweighs any possible benefit. Because the benefits of statins may include prevention of serious or potentially fatal events in a small group of very high-risk pregnant patients, contraindicating these drugs in all pregnant women is not appropriate.

FDA expects removing the contraindication will enable health care professionals and patients to make individual decisions about benefit and risk, especially for those at very high risk of heart attack or stroke. This includes patients with homozygous familial hypercholesterolemia and those who have previously had a heart attack or stroke.

BACKGROUND: Statins are a class of prescription medicines that have been used for decades to lower low-density lipoprotein (LDL-C or "bad") cholesterol in the blood. Medicines in the statin class include atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin.

RECOMMENDATIONS:

  • Patients: Patients taking statins should notify their health care professionals if they become pregnant or suspect they are pregnant. Your health care professional will be able to advise whether you should stop taking the medicine during pregnancy and whether you may stop your statin temporarily while breastfeeding. Patients who are at high risk of heart attack or stroke who require statins after giving birth should not breastfeed and should use alternatives such as infant formula.

  • Health Care Professionals: Health care professionals should discontinue statin therapy in most pregnant patients, or they can consider the ongoing therapeutic needs of the individual patient, particularly those at very high risk for cardiovascular events during pregnancy. Because of the chronic nature of cardiovascular disease, treatment of hyperlipidemia is not generally necessary during pregnancy. Discuss with patients whether they may discontinue statins temporarily while breastfeeding. Advise those who require a statin because of their cardiovascular risk that breastfeeding is not recommended because the medicine may pass into breast milk

The FDA hopes the revised language in the prescribing information will help reassure health care professionals that statins are safe to prescribe in patients who can become pregnant, and help them reassure patients with unintended statin exposure in early pregnancy or before pregnancy is recognized that the medicine is unlikely to harm the unborn baby.

For more information visit the FDA website at: http://www.fda.gov/Safety/MedWatch/SafetyInformation and http://www.fda.gov/Drugs/DrugSafety.

Simvastatin is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Simvastatin is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol (''bad cholesterol'') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol (''good cholesterol'') in the blood. Simvastatin may also be used to decrease the amount of cholesterol and other fatty substances in the blood in children and teenagers 10 to 17 years of age who have familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally). Simvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with simvastatin has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks.

Simvastatin comes as a tablet and as a suspension to take by mouth. The tablets are usually taken once a day in the evening. The suspension is usually taken once a day in the evening on an empty stomach. Take simvastatin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take simvastatin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake suspension well for at least 20 seconds before each use.

If you will be taking the simvastatin suspension, do not use a household teaspoon to measure your dose. Household teaspoons are not accurate measuring devices, and you may receive too much medication or not enough medication if you measure your dose with a household teaspoon. Instead, use a properly marked measuring device such as a medicine spoon or oral syringe. Ask your doctor or pharmacist if you need help getting or using a measuring device.

Your doctor may start you on a low dose of simvastatin and gradually increase your dose, not more than once every 4 weeks.

Continue to take simvastatin even if you feel well. Do not stop taking simvastatin without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking simvastatin,

  • tell your doctor and pharmacist if you are allergic to simvastatin, any other medications, or any of the ingredients in simvastatin tablets or oral suspension. Ask your doctor or pharmacist for a list of the ingredients.

  • tell your doctor if you are taking antifungal medications such as itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil) and voriconazole (Vfend); clarithromycin (Biaxin, in Prevpac); cobicistat-containing medications (Stribild); cyclosporine (Gengraf, Neoral, Sandimmune); danazol; erythromycin (E.E.S., E-Mycin, Erythrocin); gemfibrozil (Lopid); HIV protease inhibitors such as atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), saquinavir (Invirase), and tipranavir (Aptivus); nefazodone; telaprevir (Incivek); and telithromycin (Ketek). Your doctor will probably tell you not to take simvastatin if you are taking these medications.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); amlodipine (Norvasc, in Caduet, in Lotrel); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); colchicine (Colcrys); digoxin (Digitek, Lanoxicaps, Lanoxin); diltiazem (Cardizem, Dilacor, Tiazac); dronedarone (Multaq); other cholesterol-lowering medications such as fenofibrate (Tricor), lomitapide (Juxtapid), and niacin (nicotinic acid, Niacor, Niaspan); ranolazine (Ranexa); and verapamil (Calan, Covera, Isoptin, Verelan). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Other medications may also interact with simvastatin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you have liver disease. Your doctor will order blood tests to see how well your liver is working even if you do not think you have liver disease. Your doctor will probably tell you not to take simvastatin if you have liver disease or if the tests show that you may be developing liver disease.

  • tell your doctor if you drink more than two alcoholic beverages per day, if you are 65 years of age or older, or if you are Asian, especially if you are Chinese. Also tell your doctor if you have or have ever had an underactive thyroid gland, diabetes, seizures, muscle aches or weakness, low blood pressure, or kidney disease.

  • tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant during your treatment with simvastatin. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking simvastatin, stop taking simvastatin and call your doctor immediately. Simvastatin can harm the fetus.

  • tell your doctor if you are breastfeeding. You should not breastfeed while you are taking simvastatin.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking simvastatin. If you are hospitalized due to serious injury or infection, tell the doctor who treats you that you are taking simvastatin.

  • ask your doctor about the safe use of alcoholic beverages while you are taking simvastatin. Alcohol can increase the risk of serious side effects.

Eat a low-fat, low-cholesterol diet. Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. You can also visit the National Cholesterol Education Program (NCEP) website for additional dietary information at http://www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf.

Avoid drinking grapefruit juice while taking simvastatin.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue the regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Simvastatin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • constipation

    • stomach pain

    • nausea

    • headache

    • memory loss or forgetfulness

    • confusion

    • itchy or red skin

  • Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately or get emergency medical help.

    • muscle pain, tenderness, or weakness with or without fever or lack of energy

    • dark red urine

    • decreased urination

    • lack of energy, tiredness, or weakness

    • loss of appetite

    • pain in the upper right part of the stomach

    • yellowing of the skin or eyes

    • dark colored urine

    • fever or chills

    • flushing

    • blisters

    • rash

    • hives

    • itching

    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

    • difficulty breathing or swallowing

    • hoarseness

    • joint pain

    • sensitivity to light

  • This medication may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the tablets at room temperature and away from excess heat and moisture (not in the bathroom). Store the suspension at room temperature. Do not freeze or refrigerate the suspension. Be sure to use the suspension within 30 days of opening the bottle and discard any remaining medication after 30 days.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests during your treatment, especially if you develop symptoms of liver damage.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking simvastatin.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Juvisync® (containing Simvastatin, Sitagliptin)
  • Simcor® (containing Niacin, Simvastatin)
  • Vytorin® (containing Ezetimibe, Simvastatin)

Drug Interaction
Repaglinide Repaglinide The metabolism of Simvastatin can be decreased when combined with Repaglinide.
Montelukast Montelukast The metabolism of Simvastatin can be decreased when combined with Montelukast.
Leflunomide Leflunomide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Simvastatin can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Nevirapine can be increased when combined with Simvastatin.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Simvastatin.
Dolasetron Dolasetron The metabolism of Dolasetron can be decreased when combined with Simvastatin.
Alendronate Alendronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Alendronic acid is combined with Simvastatin.
Candesartan Candesartan The metabolism of Simvastatin can be decreased when combined with Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Simvastatin.
Clopidogrel Clopidogrel The metabolism of Simvastatin can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Simvastatin can be increased when it is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The excretion of Simvastatin can be decreased when combined with Conjugated estrogens.
Nafarelin Nafarelin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Nafarelin.
Paregoric Paregoric The serum concentration of Simvastatin can be increased when it is combined with Morphine.
Penbutolol Penbutolol The metabolism of Simvastatin can be decreased when combined with Acebutolol.
Ranitidine Ranitidine The metabolism of Simvastatin can be decreased when combined with Ranitidine.
Reserpine Reserpine Reserpine may decrease the excretion rate of Simvastatin which could result in a higher serum level.
Sumatriptan Sumatriptan The excretion of Sumatriptan can be decreased when combined with Simvastatin.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Simvastatin.
Triamcinolone Triamcinolone The metabolism of Simvastatin can be increased when combined with Triamcinolone.
Fluconazole Injection Fluconazole Injection The metabolism of Simvastatin can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Hydromorphone can be decreased when combined with Simvastatin.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be increased when combined with Simvastatin.
Metoclopramide Injection Metoclopramide Injection The metabolism of Simvastatin can be decreased when combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Simvastatin.
Morphine Injection Morphine Injection The serum concentration of Simvastatin can be increased when it is combined with Morphine.
Pamidronate Injection Pamidronate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pamidronic acid is combined with Simvastatin.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Simvastatin.
Altretamine Altretamine The metabolism of Simvastatin can be decreased when combined with Amphetamine.
Cyclosporine Cyclosporine The serum concentration of Simvastatin can be increased when it is combined with Cyclosporine.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Simvastatin.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Simvastatin.
Olanzapine Olanzapine The metabolism of Simvastatin can be decreased when combined with Olanzapine.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Simvastatin.
Entacapone Entacapone The metabolism of Simvastatin can be decreased when combined with Entacapone.
Eprosartan Eprosartan The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Eprosartan.
Hydroxychloroquine Hydroxychloroquine The metabolism of Simvastatin can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam The metabolism of Meloxicam can be decreased when combined with Simvastatin.
Oxcarbazepine Oxcarbazepine The metabolism of Simvastatin can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole The excretion of Simvastatin can be decreased when combined with Pantoprazole.
Risedronate Risedronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Risedronic acid.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Simvastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan Simvastatin may decrease the excretion rate of Telmisartan which could result in a higher serum level.
Zaleplon Zaleplon The metabolism of Zaleplon can be decreased when combined with Simvastatin.
Anakinra Anakinra The metabolism of Simvastatin can be increased when combined with Anakinra.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Simvastatin.
Etanercept Injection Etanercept Injection The metabolism of Simvastatin can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Simvastatin can be increased when combined with Modafinil.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Simvastatin.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Simvastatin.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Simvastatin.
Eplerenone Eplerenone The metabolism of Eplerenone can be decreased when combined with Simvastatin.
Escitalopram Escitalopram The serum concentration of Simvastatin can be increased when it is combined with Escitalopram.
Olmesartan Olmesartan Olmesartan may decrease the excretion rate of Simvastatin which could result in a higher serum level.
Zonisamide Zonisamide The serum concentration of Simvastatin can be increased when it is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Simvastatin can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Simvastatin.
Atomoxetine Atomoxetine The metabolism of Simvastatin can be decreased when combined with Atomoxetine.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Simvastatin.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Simvastatin.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Simvastatin.
Mefloquine Mefloquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Mefloquine is combined with Simvastatin.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Simvastatin.
Vardenafil Vardenafil The serum concentration of Vardenafil can be increased when it is combined with Simvastatin.
Aprepitant Aprepitant The metabolism of Simvastatin can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The metabolism of Simvastatin can be decreased when combined with Tegaserod.
Tadalafil Tadalafil The metabolism of Tadalafil can be decreased when combined with Simvastatin.
Progesterone Progesterone The metabolism of Simvastatin can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Simvastatin.
Infliximab Injection Infliximab Injection The metabolism of Simvastatin can be increased when combined with Infliximab.
Protriptyline Protriptyline The metabolism of Simvastatin can be decreased when combined with Protriptyline.
Rifaximin Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Simvastatin.
Duloxetine Duloxetine The metabolism of Simvastatin can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Simvastatin.
Tinidazole Tinidazole Simvastatin may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium Trospium The metabolism of Simvastatin can be decreased when combined with Trospium.
Bosentan Bosentan The serum concentration of Simvastatin can be decreased when it is combined with Bosentan.
Cinacalcet Cinacalcet The metabolism of Simvastatin can be decreased when combined with Cinacalcet.
Erlotinib Erlotinib The metabolism of Simvastatin can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Simvastatin.
Ganciclovir Ganciclovir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Ganciclovir.
Solifenacin Solifenacin The metabolism of Solifenacin can be decreased when combined with Simvastatin.
Voriconazole Voriconazole The serum concentration of Simvastatin can be increased when it is combined with Voriconazole.
Dextroamphetamine Dextroamphetamine The metabolism of Simvastatin can be decreased when combined with Amphetamine.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Simvastatin can be decreased when combined with Peginterferon alfa-2b.
Ibandronate Ibandronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Ibandronate.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Simvastatin.
Darifenacin Darifenacin The metabolism of Simvastatin can be decreased when combined with Darifenacin.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Simvastatin.
Deferasirox Deferasirox The metabolism of Simvastatin can be decreased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Simvastatin.
Ranolazine Ranolazine The risk or severity of myopathy and rhabdomyolysis can be increased when Ranolazine is combined with Simvastatin.
Abatacept Injection Abatacept Injection The metabolism of Simvastatin can be increased when combined with Abatacept.
Imatinib Imatinib The serum concentration of Simvastatin can be increased when it is combined with Imatinib.
Gefitinib Gefitinib The metabolism of Simvastatin can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The serum concentration of Simvastatin can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Simvastatin.
Posaconazole Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Simvastatin.
Primaquine Primaquine The metabolism of Simvastatin can be decreased when combined with Primaquine.
Darunavir Darunavir The excretion of Simvastatin can be decreased when combined with Darunavir.
Lisdexamfetamine Lisdexamfetamine The metabolism of Simvastatin can be decreased when combined with Lisdexamfetamine.
Nabilone Nabilone The metabolism of Simvastatin can be decreased when combined with Nabilone.
Sorafenib Sorafenib The metabolism of Simvastatin can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Simvastatin.
Dronabinol Dronabinol The metabolism of Simvastatin can be decreased when combined with Dronabinol.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Simvastatin.
Dasatinib Dasatinib The serum concentration of Dasatinib can be increased when it is combined with Simvastatin.
Mexiletine Mexiletine The metabolism of Mexiletine can be increased when combined with Simvastatin.
Armodafinil Armodafinil The metabolism of Simvastatin can be increased when combined with Armodafinil.
Ivermectin Ivermectin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ivermectin is combined with Simvastatin.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Simvastatin.
Nilotinib Nilotinib The metabolism of Simvastatin can be decreased when combined with Nilotinib.
Toremifene Toremifene The serum concentration of Simvastatin can be increased when it is combined with Toremifene.
Raltegravir Raltegravir The risk or severity of myopathy and rhabdomyolysis can be increased when Raltegravir is combined with Simvastatin.
Bexarotene Bexarotene The metabolism of Bexarotene can be decreased when combined with Simvastatin.
Budesonide Budesonide The metabolism of Simvastatin can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Simvastatin can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The serum concentration of Simvastatin can be decreased when it is combined with Etravirine.
Desvenlafaxine Desvenlafaxine The metabolism of Simvastatin can be decreased when combined with Desvenlafaxine.
Cevimeline Cevimeline The metabolism of Simvastatin can be decreased when combined with Cevimeline.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Simvastatin.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Simvastatin.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Simvastatin.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Simvastatin.
Certolizumab Injection Certolizumab Injection The metabolism of Simvastatin can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection The metabolism of Simvastatin can be increased when combined with Irinotecan.
Daptomycin Injection Daptomycin Injection The risk or severity of myopathy can be increased when Simvastatin is combined with Daptomycin.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Simvastatin.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Simvastatin.
Midazolam Midazolam The metabolism of Midazolam can be decreased when combined with Simvastatin.
Naltrexone Injection Naltrexone Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Naltrexone.
Eltrombopag Eltrombopag The metabolism of Simvastatin can be decreased when combined with Eltrombopag.
Fesoterodine Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Simvastatin.
Betaxolol Betaxolol The metabolism of Simvastatin can be decreased when combined with Betaxolol.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Simvastatin.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Simvastatin.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Simvastatin.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Simvastatin.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Simvastatin.
Dronedarone Dronedarone The serum concentration of Simvastatin can be increased when it is combined with Dronedarone.
Palonosetron Injection Palonosetron Injection The metabolism of Simvastatin can be decreased when combined with Palonosetron.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Simvastatin.
Romidepsin Injection Romidepsin Injection The serum concentration of Simvastatin can be increased when it is combined with Romidepsin.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Simvastatin.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Simvastatin.
Golimumab Injection Golimumab Injection The metabolism of Simvastatin can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Simvastatin.
Pitavastatin Pitavastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Pitavastatin.
Levonorgestrel Levonorgestrel The metabolism of Simvastatin can be decreased when combined with Levonorgestrel.
Oxymorphone Oxymorphone The metabolism of Oxymorphone can be decreased when combined with Simvastatin.
Tocilizumab Injection Tocilizumab Injection The metabolism of Simvastatin can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Simvastatin can be increased when it is combined with Cabazitaxel.
Acetaminophen Injection Acetaminophen Injection The metabolism of Simvastatin can be decreased when combined with Acetaminophen.
Vilazodone Vilazodone The metabolism of Simvastatin can be decreased when combined with Vilazodone.
Linagliptin Linagliptin The serum concentration of Linagliptin can be increased when it is combined with Simvastatin.
Rilpivirine Rilpivirine The metabolism of Simvastatin can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Simvastatin.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Simvastatin can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Simvastatin can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Simvastatin.
Ticagrelor Ticagrelor The serum concentration of Simvastatin can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Simvastatin.
Vandetanib Vandetanib The serum concentration of Simvastatin can be increased when it is combined with Vandetanib.
Clobazam Clobazam The metabolism of Simvastatin can be decreased when combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Simvastatin can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Vismodegib can be decreased when combined with Simvastatin.
Ivacaftor Ivacaftor The serum concentration of Ivacaftor can be increased when it is combined with Simvastatin.
Axitinib Axitinib The serum concentration of Axitinib can be increased when it is combined with Simvastatin.
Crizotinib Crizotinib The serum concentration of Simvastatin can be increased when it is combined with Crizotinib.
Cabergoline Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Simvastatin.
Ambrisentan Ambrisentan The serum concentration of Simvastatin can be increased when it is combined with Ambrisentan.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Simvastatin can be increased when it is combined with Carfilzomib.
Iloprost Iloprost The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Iloprost.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be decreased when combined with Simvastatin.
Mirabegron Mirabegron The metabolism of Mirabegron can be decreased when combined with Simvastatin.
Regorafenib Regorafenib The serum concentration of Simvastatin can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Simvastatin.
Teriflunomide Teriflunomide The metabolism of Simvastatin can be decreased when combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Simvastatin.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Simvastatin.
Ponatinib Ponatinib The metabolism of Simvastatin can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide The serum concentration of Simvastatin can be increased when it is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Simvastatin.
Apixaban Apixaban The serum concentration of Simvastatin can be increased when it is combined with Apixaban.
Canagliflozin Canagliflozin The serum concentration of Simvastatin can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Simvastatin.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Simvastatin.
Trametinib Trametinib The metabolism of Simvastatin can be decreased when combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Simvastatin.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Simvastatin.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Simvastatin.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Simvastatin.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Simvastatin.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Simvastatin.
Lomitapide Lomitapide The serum concentration of Simvastatin can be increased when it is combined with Lomitapide.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Simvastatin.
Simeprevir Simeprevir The serum concentration of Simvastatin can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Simvastatin.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Simvastatin.
Apremilast Apremilast The metabolism of Simvastatin can be increased when combined with Apremilast.
Ceritinib Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Simvastatin.
Siltuximab Injection Siltuximab Injection The metabolism of Simvastatin can be increased when combined with Siltuximab.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Simvastatin.
Idelalisib Idelalisib The serum concentration of Idelalisib can be increased when it is combined with Simvastatin.
Testosterone Injection Testosterone Injection The metabolism of Simvastatin can be decreased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Simvastatin can be decreased when combined with Oritavancin.
Vorapaxar Vorapaxar The serum concentration of Simvastatin can be increased when it is combined with Vorapaxar.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be increased when combined with Simvastatin.
Suvorexant Suvorexant The serum concentration of Simvastatin can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Simvastatin.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Simvastatin.
Caspofungin Injection Caspofungin Injection The excretion of Simvastatin can be decreased when combined with Caspofungin.
Methamphetamine Methamphetamine The metabolism of Metamfetamine can be decreased when combined with Simvastatin.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Simvastatin.
Nintedanib Nintedanib The serum concentration of Nintedanib can be increased when it is combined with Simvastatin.
Secukinumab Injection Secukinumab Injection The metabolism of Simvastatin can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Risperidone can be decreased when combined with Simvastatin.
Palbociclib Palbociclib The serum concentration of Palbociclib can be increased when it is combined with Simvastatin.
Lenvatinib Lenvatinib The serum concentration of Lenvatinib can be increased when it is combined with Simvastatin.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Simvastatin.
Panobinostat Panobinostat The metabolism of Simvastatin can be decreased when combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The serum concentration of Simvastatin can be increased when it is combined with Haloperidol.
Deoxycholic Acid Injection Deoxycholic Acid Injection Deoxycholic acid may increase the excretion rate of Simvastatin which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Simvastatin can be increased when it is combined with Isavuconazonium.
Flibanserin Flibanserin The serum concentration of Simvastatin can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The metabolism of Simvastatin can be decreased when combined with Rolapitant.
Daclatasvir Daclatasvir The serum concentration of Simvastatin can be increased when it is combined with Daclatasvir.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Simvastatin.
Ziprasidone Injection Ziprasidone Injection The metabolism of Simvastatin can be decreased when combined with Ziprasidone.
Cariprazine Cariprazine The metabolism of Cariprazine can be decreased when combined with Simvastatin.
Eluxadoline Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Simvastatin.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Simvastatin.
Trabectedin Injection Trabectedin Injection The risk or severity of myopathy and rhabdomyolysis can be increased when Simvastatin is combined with Trabectedin.
Osimertinib Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Simvastatin.
Rifapentine Rifapentine The metabolism of Simvastatin can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Simvastatin.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Simvastatin can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Simvastatin.
Venetoclax Venetoclax The serum concentration of Venetoclax can be increased when it is combined with Simvastatin.
Cobicistat Cobicistat The metabolism of Simvastatin can be decreased when combined with Cobicistat.
Selexipag Selexipag The serum concentration of Simvastatin can be increased when it is combined with Selexipag.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Simvastatin.
Rucaparib Rucaparib The metabolism of Simvastatin can be decreased when combined with Rucaparib.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Simvastatin.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Simvastatin.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Simvastatin.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Simvastatin.
Deflazacort Deflazacort The metabolism of Simvastatin can be increased when combined with Deflazacort.
Safinamide Safinamide The metabolism of Simvastatin can be decreased when combined with Safinamide.
Midostaurin Midostaurin The metabolism of Simvastatin can be decreased when combined with Midostaurin.
Neratinib Neratinib The serum concentration of Simvastatin can be increased when it is combined with Neratinib.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Simvastatin.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Simvastatin.
Copanlisib Injection Copanlisib Injection The serum concentration of Simvastatin can be increased when it is combined with Copanlisib.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Simvastatin.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Simvastatin.
Acalabrutinib Acalabrutinib The metabolism of Simvastatin can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Simvastatin can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Simvastatin.
Ertugliflozin Ertugliflozin The metabolism of Simvastatin can be decreased when combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Simvastatin.
Apalutamide Apalutamide The serum concentration of Simvastatin can be decreased when it is combined with Apalutamide.
Penicillamine Penicillamine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Penicillamine.
Fostamatinib Fostamatinib The metabolism of Simvastatin can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Simvastatin.
Baricitinib Baricitinib The serum concentration of Simvastatin can be increased when it is combined with Baricitinib.
Lofexidine Lofexidine The metabolism of Lofexidine can be decreased when combined with Simvastatin.
Eliglustat Eliglustat The metabolism of Simvastatin can be decreased when combined with Eliglustat.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Simvastatin.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Simvastatin.
Ivosidenib Ivosidenib The serum concentration of Ivosidenib can be increased when it is combined with Simvastatin.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Simvastatin.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Simvastatin.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Simvastatin.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Simvastatin.
Cannabidiol Cannabidiol The metabolism of Simvastatin can be decreased when combined with Cannabidiol.
Dacomitinib Dacomitinib The serum concentration of Simvastatin can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Simvastatin.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Simvastatin.
Sarecycline Sarecycline The serum concentration of Simvastatin can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Simvastatin can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Simvastatin.
Gilteritinib Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Simvastatin.
Glasdegib Glasdegib The serum concentration of Simvastatin can be increased when it is combined with Glasdegib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Simvastatin.
Larotrectinib Larotrectinib The serum concentration of Simvastatin can be increased when it is combined with Larotrectinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Simvastatin.
Rifamycin Rifamycin The metabolism of Simvastatin can be decreased when combined with Rifamycin.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Simvastatin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Simvastatin can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Simvastatin.
Erdafitinib Erdafitinib The serum concentration of Simvastatin can be increased when it is combined with Erdafitinib.
Alpelisib Alpelisib The metabolism of Simvastatin can be decreased when combined with Alpelisib.
Cladribine Cladribine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Cladribine is combined with Simvastatin.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Simvastatin.
Triclabendazole Triclabendazole The metabolism of Simvastatin can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The serum concentration of Entrectinib can be increased when it is combined with Simvastatin.
Pexidartinib Pexidartinib The metabolism of Simvastatin can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Simvastatin.
Pitolisant Pitolisant The serum concentration of Simvastatin can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Simvastatin.
Lefamulin Lefamulin Simvastatin may decrease the excretion rate of Lefamulin which could result in a higher serum level.
Phenytoin Injection Phenytoin Injection The serum concentration of Simvastatin can be decreased when it is combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Simvastatin can be decreased when it is combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Simvastatin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Simvastatin.
Voxelotor Voxelotor The metabolism of Voxelotor can be increased when combined with Simvastatin.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Simvastatin.
Lasmiditan Lasmiditan The serum concentration of Simvastatin can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Simvastatin.
Tazemetostat Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Simvastatin.
Bempedoic Acid Bempedoic Acid The risk or severity of myopathy can be increased when Bempedoic acid is combined with Simvastatin.
Cenobamate Cenobamate The serum concentration of Simvastatin can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Simvastatin.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Simvastatin.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Simvastatin.
Tucatinib Tucatinib Simvastatin may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Simvastatin.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Simvastatin.
Selpercatinib Selpercatinib The serum concentration of Simvastatin can be increased when it is combined with Selpercatinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Simvastatin.
Fenfluramine Fenfluramine The metabolism of Simvastatin can be decreased when combined with Fenfluramine.
Fostemsavir Fostemsavir The serum concentration of Simvastatin can be increased when it is combined with Fostemsavir.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Simvastatin.
Pralsetinib Pralsetinib The serum concentration of Simvastatin can be increased when it is combined with Pralsetinib.
Opicapone Opicapone The metabolism of Simvastatin can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Simvastatin can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Simvastatin.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Simvastatin.
Indomethacin Indomethacin The metabolism of Simvastatin can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The metabolism of Simvastatin can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Simvastatin.
Trazodone Trazodone The metabolism of Trazodone can be decreased when combined with Simvastatin.
Isotretinoin Isotretinoin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Isotretinoin.
Hydroxyurea Hydroxyurea The metabolism of Simvastatin can be decreased when combined with Hydroxyurea.
Phenobarbital Phenobarbital The metabolism of Simvastatin can be decreased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Methotrexate.
Primidone Primidone The metabolism of Primidone can be decreased when combined with Simvastatin.
Chlorpromazine Chlorpromazine The metabolism of Simvastatin can be decreased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Simvastatin.
Codeine Codeine The metabolism of Simvastatin can be decreased when combined with Codeine.
Tranylcypromine Tranylcypromine The metabolism of Simvastatin can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Simvastatin can be decreased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Procarbazine.
Minocycline Minocycline The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Minocycline.
Prochlorperazine Prochlorperazine The metabolism of Simvastatin can be decreased when combined with Prochlorperazine.
Thioridazine Thioridazine The metabolism of Simvastatin can be decreased when combined with Thioridazine.
Dapsone Dapsone The metabolism of Simvastatin can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Simvastatin.
Oxycodone Oxycodone The metabolism of Simvastatin can be decreased when combined with Oxycodone.
Methadone Methadone The metabolism of Simvastatin can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Simvastatin.
Benztropine Benztropine The metabolism of Simvastatin can be decreased when combined with Benzatropine.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Simvastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline Maprotiline The metabolism of Maprotiline can be decreased when combined with Simvastatin.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Simvastatin.
Orphenadrine Orphenadrine The metabolism of Simvastatin can be decreased when combined with Orphenadrine.
Perphenazine Perphenazine The metabolism of Simvastatin can be decreased when combined with Perphenazine.
Fluphenazine Fluphenazine The metabolism of Simvastatin can be decreased when combined with Fluphenazine.
Amoxapine Amoxapine The metabolism of Simvastatin can be decreased when combined with Amoxapine.
Sulfasalazine Sulfasalazine The excretion of Simvastatin can be decreased when combined with Sulfasalazine.
Hydrocortisone Hydrocortisone The metabolism of Simvastatin can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Simvastatin.
Cytarabine Cytarabine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Cytarabine.
Dactinomycin Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Simvastatin.
Carbamazepine Carbamazepine The metabolism of Simvastatin can be decreased when combined with Carbamazepine.
Methyldopa Methyldopa The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Methyldopa.
Clonidine Clonidine The metabolism of Simvastatin can be decreased when combined with Clonidine.
Cimetidine Cimetidine The serum concentration of Simvastatin can be increased when it is combined with Cimetidine.
Warfarin Warfarin Simvastatin may increase the anticoagulant activities of Warfarin.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Simvastatin.
Promethazine Promethazine The metabolism of Simvastatin can be decreased when combined with Promethazine.
Daunorubicin Daunorubicin Daunorubicin may decrease the excretion rate of Simvastatin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Simvastatin may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Simvastatin can be increased when combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Simvastatin.
Loxapine Loxapine The serum concentration of Simvastatin can be increased when it is combined with Loxapine.
Chloroquine Chloroquine The metabolism of Simvastatin can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Simvastatin can be decreased when combined with Quinine.
Sulfinpyrazone Sulfinpyrazone The metabolism of Simvastatin can be decreased when combined with Sulfinpyrazone.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Simvastatin.
Secobarbital Secobarbital The metabolism of Simvastatin can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Simvastatin can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Simvastatin.
Imipramine Imipramine The metabolism of Simvastatin can be decreased when combined with Imipramine.
Probenecid Probenecid The metabolism of Simvastatin can be increased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Simvastatin can be increased when it is combined with Quinidine.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Simvastatin.
Isoniazid Isoniazid The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Isoniazid.
Rifampin Rifampin The metabolism of Simvastatin can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Simvastatin can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be increased when combined with Simvastatin.
Levothyroxine Levothyroxine The metabolism of Simvastatin can be decreased when combined with Levothyroxine.
Liothyronine Liothyronine The excretion of Liothyronine can be decreased when combined with Simvastatin.
Methimazole Methimazole The metabolism of Simvastatin can be decreased when combined with Methimazole.
Propylthiouracil Propylthiouracil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Propylthiouracil is combined with Simvastatin.
Chlorpropamide Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Simvastatin.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Simvastatin.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Simvastatin.
Dextromethorphan Dextromethorphan The metabolism of Simvastatin can be decreased when combined with Dextromethorphan.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Simvastatin.
Baclofen Baclofen The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Baclofen is combined with Simvastatin.
Clemastine Clemastine The metabolism of Simvastatin can be decreased when combined with Clemastine.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Simvastatin.
Brompheniramine Brompheniramine The metabolism of Brompheniramine can be increased when combined with Simvastatin.
Meclizine Meclizine The metabolism of Meclizine can be decreased when combined with Simvastatin.
Chlorzoxazone Chlorzoxazone The metabolism of Simvastatin can be decreased when combined with Chlorzoxazone.
Danazol Danazol The serum concentration of Simvastatin can be increased when it is combined with Danazol.
Disulfiram Disulfiram Simvastatin may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Simvastatin can be decreased when combined with Propranolol.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Simvastatin.
Spironolactone Spironolactone The metabolism of Simvastatin can be decreased when combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Amphotericin B.
Nadolol Nadolol The metabolism of Nadolol can be decreased when combined with Simvastatin.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Simvastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Simvastatin.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Simvastatin.
Colchicine Colchicine The risk or severity of myopathy and rhabdomyolysis can be increased when Colchicine is combined with Simvastatin.
Cefaclor Cefaclor Simvastatin may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Nystatin Nystatin The excretion of Simvastatin can be decreased when combined with Nystatin.
Ketoconazole Ketoconazole The metabolism of Simvastatin can be decreased when combined with Ketoconazole.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Simvastatin.
Captopril Captopril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Captopril.
Dipyridamole Dipyridamole Dipyridamole may decrease the excretion rate of Simvastatin which could result in a higher serum level.
Vinblastine Vinblastine The serum concentration of Simvastatin can be increased when it is combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Simvastatin can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine The metabolism of Simvastatin can be decreased when combined with Hydroxyzine.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Simvastatin.
Alprazolam Alprazolam The metabolism of Simvastatin can be decreased when combined with Alprazolam.
Triazolam Triazolam The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Triazolam.
Trimethoprim Trimethoprim The metabolism of Simvastatin can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The serum concentration of Simvastatin can be increased when it is combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Nifedipine can be decreased when combined with Simvastatin.
Timolol Timolol The metabolism of Simvastatin can be decreased when combined with Timolol.
Verapamil Verapamil The risk or severity of myopathy and rhabdomyolysis can be increased when Verapamil is combined with Simvastatin.
Atenolol Atenolol Atenolol may decrease the excretion rate of Simvastatin which could result in a higher serum level.
Pindolol Pindolol The metabolism of Simvastatin can be decreased when combined with Pindolol.
Piroxicam Piroxicam The metabolism of Simvastatin can be decreased when combined with Piroxicam.
Bumetanide Bumetanide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Bumetanide.
Etoposide Etoposide The serum concentration of Etoposide can be increased when it is combined with Simvastatin.
Glyburide Glyburide The metabolism of Glyburide can be decreased when combined with Simvastatin.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Simvastatin.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Simvastatin.
Labetalol Labetalol The metabolism of Simvastatin can be decreased when combined with Labetalol.
Leuprolide Injection Leuprolide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leuprolide is combined with Simvastatin.
Gemfibrozil Gemfibrozil The risk or severity of rhabdomyolysis, myoglobinuria, and elevated creatine kinase (CPK) can be increased when Gemfibrozil is combined with Simvastatin.
Ketoprofen Ketoprofen The metabolism of Ketoprofen can be decreased when combined with Simvastatin.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Simvastatin.
Enalapril Enalapril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Enalapril.
Flurbiprofen Flurbiprofen The metabolism of Simvastatin can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The serum concentration of Simvastatin can be increased when it is combined with Amiodarone.
Buspirone Buspirone The metabolism of Simvastatin can be decreased when combined with Buspirone.
Lovastatin Lovastatin The metabolism of Simvastatin can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Simvastatin can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Simvastatin can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The serum concentration of Fluoxetine can be increased when it is combined with Simvastatin.
Clozapine Clozapine The metabolism of Simvastatin can be decreased when combined with Clozapine.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Simvastatin.
Ofloxacin Ofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Ofloxacin.
Clarithromycin Clarithromycin The serum concentration of Simvastatin can be increased when it is combined with Clarithromycin.
Etodolac Etodolac The metabolism of Etodolac can be decreased when combined with Simvastatin.
Felodipine Felodipine The metabolism of Simvastatin can be decreased when combined with Felodipine.
Nabumetone Nabumetone The metabolism of Nabumetone can be decreased when combined with Simvastatin.
Pravastatin Pravastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Simvastatin.
Amlodipine Amlodipine The serum concentration of Simvastatin can be increased when it is combined with Amlodipine.
Teniposide Injection Teniposide Injection The metabolism of Simvastatin can be decreased when combined with Teniposide.
Itraconazole Itraconazole The serum concentration of Simvastatin can be increased when it is combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Simvastatin can be increased when combined with Rifabutin.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Simvastatin.
Bisoprolol Bisoprolol The serum concentration of Simvastatin can be increased when it is combined with Bisoprolol.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Simvastatin.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Simvastatin.
Isradipine Isradipine Isradipine may decrease the excretion rate of Simvastatin which could result in a higher serum level.
Omeprazole Omeprazole The metabolism of Omeprazole can be decreased when combined with Simvastatin.
Cisapride Cisapride The metabolism of Simvastatin can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Simvastatin.
Venlafaxine Venlafaxine The metabolism of Simvastatin can be decreased when combined with Venlafaxine.
Nizatidine Nizatidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nizatidine is combined with Simvastatin.
Stavudine Stavudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Stavudine.
Fluvoxamine Fluvoxamine The metabolism of Simvastatin can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone Nefazodone may decrease the excretion rate of Simvastatin which could result in a higher serum level.
Lamotrigine Lamotrigine The metabolism of Simvastatin can be increased when combined with Lamotrigine.
Losartan Losartan The metabolism of Simvastatin can be decreased when combined with Losartan.
Tramadol Tramadol The metabolism of Simvastatin can be increased when combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Simvastatin can be decreased when combined with Vinorelbine.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Simvastatin.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Simvastatin.
Nicardipine Nicardipine The metabolism of Simvastatin can be decreased when combined with Nicardipine.
Bupropion Bupropion The serum concentration of Bupropion can be increased when it is combined with Simvastatin.
Ticlopidine Ticlopidine The metabolism of Simvastatin can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Simvastatin can be decreased when combined with Saquinavir.
Metformin Metformin Metformin may increase the hypolipidaemic activities of Simvastatin.
Nisoldipine Nisoldipine The metabolism of Simvastatin can be decreased when combined with Nisoldipine.
Lamivudine Lamivudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Lamivudine.
Glimepiride Glimepiride The metabolism of Glimepiride can be decreased when combined with Simvastatin.
Anastrozole Anastrozole The metabolism of Anastrozole can be decreased when combined with Simvastatin.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Simvastatin.
Indinavir Indinavir Indinavir may decrease the excretion rate of Simvastatin which could result in a higher serum level.
Ritonavir Ritonavir The metabolism of Simvastatin can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Simvastatin.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Simvastatin.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Simvastatin.
Mirtazapine Mirtazapine The metabolism of Simvastatin can be decreased when combined with Mirtazapine.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Simvastatin.
Valsartan Valsartan The metabolism of Valsartan can be decreased when combined with Simvastatin.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Simvastatin.
Nelfinavir Nelfinavir The metabolism of Nelfinavir can be decreased when combined with Simvastatin.
Fexofenadine Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Simvastatin.
Loratadine Loratadine The metabolism of Simvastatin can be decreased when combined with Loratadine.
Carvedilol Carvedilol The metabolism of Simvastatin can be decreased when combined with Carvedilol.
Nilutamide Nilutamide The metabolism of Simvastatin can be decreased when combined with Nilutamide.
Flutamide Flutamide The metabolism of Simvastatin can be decreased when combined with Flutamide.
Selegiline Selegiline The metabolism of Simvastatin can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Simvastatin can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Simvastatin can be decreased when combined with Sertraline.
Propafenone Propafenone The metabolism of Simvastatin can be decreased when combined with Propafenone.
Letrozole Letrozole The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Letrozole.
Raloxifene Raloxifene The metabolism of Simvastatin can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Simvastatin.
Tamsulosin Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Simvastatin.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Simvastatin.
Quetiapine Quetiapine The metabolism of Quetiapine can be decreased when combined with Simvastatin.
Paroxetine Paroxetine The metabolism of Simvastatin can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Simvastatin can be decreased when combined with Citalopram.
Capecitabine Capecitabine The metabolism of Capecitabine can be decreased when combined with Simvastatin.
Efavirenz Efavirenz The serum concentration of Simvastatin can be decreased when it is combined with Efavirenz.
Sildenafil Sildenafil The metabolism of Sildenafil can be decreased when combined with Simvastatin.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be decreased when combined with Simvastatin.
Celecoxib Celecoxib The metabolism of Simvastatin can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Simvastatin can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Simvastatin.
Thalidomide Thalidomide The metabolism of Simvastatin can be increased when combined with Thalidomide.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Simvastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Simvastatin.
Galantamine Galantamine The metabolism of Galantamine can be decreased when combined with Simvastatin.
Rabeprazole Rabeprazole The metabolism of Simvastatin can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Simvastatin can be decreased when combined with Terbinafine.

* This branded product is no longer on the market. Generic alternatives may be available.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists