FDA-filed SPL labeling · retrieved through openFDA

Tretinoin

Tretinoin is a vitamin A-derived cream used to help reduce the appearance of fine facial wrinkles as part of a full skin care routine.

Brand names VesanoidRetin-AAltrenoAvitaAtralin +4 more
Drug class ⓘ Retinoid
Rx Forms 2 Routes Topical · Oral
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 56 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveApr 16, 2026
Clinical labels in scope ⓘ56
AvailabilityRx
Earliest approval/marketing year ⓘ1971
FDA-listed product records ⓘ194
Boxed warningNone found in compared labels
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 22, 2026
Other forms & routes:
Topical
⭐ Tretinoin at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Tretinoin cream can help soften the appearance of fine wrinkles when used as part of a consistent skin care and sun-protection routine — but it won't erase wrinkles or undo significant sun damage. Skin irritation, especially in the first few weeks, is common and usually manageable by using less or applying less often. Sun protection every single day is non-negotiable while you're on this medication.
How we write & review this content — our editorial policy →

📖 Tretinoin: Patient Information Guide

A plain-language walkthrough of Tretinoin — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Tretinoin cream is used to help reduce the appearance of fine facial wrinkles. Here's what the label specifically says it is — and isn't — approved for:

  • Approved use: Lessening the look of fine facial wrinkles as an add-on to a full skin care and sun-avoidance routine
  • Not effective for: Deep or coarse wrinkles
  • Not effective for: Rough skin texture or enlarged pores
  • Not effective for: Dark spots (mottled hyperpigmentation) or age spots (lentigines)
  • Not effective for: Skin sagging, visible blood vessels (telangiectasia), or reversing general sun damage
  • Not studied in: People with actinic keratoses (pre-cancerous spots) or a history of skin cancer
⚙️How it works▾

Tretinoin is a natural metabolite — a breakdown product — of vitamin A. It works by binding to specific receptors inside skin cells called retinoic acid receptors (RAR). These receptors influence how genes are expressed, which in turn affects how skin cells grow, divide, and shed. Tretinoin appears to speed up cell turnover and reduce the stickiness of cells lining the pores, which helps with both acne and the texture of skin.

That said, the exact way these cellular changes lead to fewer visible fine wrinkles isn't completely understood — the science points to receptor activation, but other mechanisms may also be involved.

💊How it's taken▾

Tretinoin gel is applied to the skin once daily, typically in the evening, after gently washing and drying the affected area. Use a thin layer — just enough to cover the area. More product does not mean better or faster results; it just means more irritation.

  • Apply to clean, dry skin in the evening
  • Keep away from eyes, mouth, nostrils, and mucous membranes
  • If irritation occurs, your doctor may suggest applying less often until your skin adjusts
  • It may take more than seven weeks before you see consistent improvement
🤒Side effects — in detail▾

Most people notice some skin irritation, especially in the first couple of weeks — this is normal and often settles down over time. Common reactions include:

  • Redness and skin flushing
  • Peeling or flaking
  • Dryness
  • Burning, stinging, or itching on application
  • Temporary warmth after applying
  • An initial flare-up of acne in the first few weeks (this usually passes)

If you develop blistering, severe swelling, or skin irritation that doesn't improve after backing off on the frequency of use, contact your prescriber — you may need to stop the medication.

⚠️Warnings & precautions▾
  • Sun sensitivity: Tretinoin significantly increases your skin's sensitivity to sunlight. Wear SPF 15+ sunscreen daily, use protective clothing, and avoid tanning beds. Don't apply to sunburned skin.
  • Photosensitizing drugs: Taking certain medications (like some antibiotics, diuretics, or antipsychotics) alongside tretinoin can amplify this sun sensitivity even further — tell your doctor about all your medications.
  • Skin irritation: Tretinoin is a dermal irritant. Using too much or too often won't help — it will cause more redness, peeling, and discomfort. If irritation is severe, reduce application or stop temporarily.
  • Eczema: Tretinoin can cause severe irritation on eczematous (inflamed, sensitive) skin — avoid using it on those areas.
  • Long-term use: Daily use beyond 52 weeks has not been fully studied. Continued use should be under medical supervision.
🔀What it interacts with▾

Several products and medications can interact with tretinoin — mostly by increasing skin irritation or sun sensitivity:

  • Photosensitizing drugs (tetracyclines, fluoroquinolones, thiazide diuretics, phenothiazines, sulfonamides) — increase risk of sunburn and skin damage when combined with tretinoin
  • Harsh topical products (medicated soaps, astringents, high-alcohol toners, abrasive scrubs) — increase skin irritation
  • OTC acne products (benzoyl peroxide, salicylic acid, sulfur, resorcinol) — can worsen irritation; let these effects subside before starting tretinoin
  • Lime peel — direct contact should be avoided
  • Hair removal products (waxes, depilatories, permanent wave solutions) — may irritate skin treated with tretinoin

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Do not use if you are allergic to tretinoin or any other ingredient in the product — stop immediately if a reaction develops
  • Tell your doctor if you have eczema — tretinoin can severely irritate already-inflamed skin
  • Tell your doctor if you are pregnant or trying to become pregnant; animal studies showed fetal abnormalities at high doses, though human data from topical use have not confirmed a risk
  • History of skin cancer or visible actinic keratoses (pre-cancerous sun spots): safety and effectiveness have not been established in these groups
  • If your job or lifestyle involves a lot of sun exposure, discuss extra precautions with your prescriber
  • Safety beyond 52 weeks of daily use has not been established — long-term use requires ongoing medical supervision
🚑If you take too much▾

Applying more tretinoin than directed will not improve your results — it will only cause more redness, peeling, and skin discomfort. If the product is accidentally swallowed, it may cause the same effects as taking too much vitamin A by mouth. If accidental ingestion occurs, seek medical attention or contact Poison Control.

📡Pharmacodynamics — effects in the body▾

When tretinoin is applied to skin, it works at the cellular level to increase skin cell turnover and reduce the tendency of cells inside hair follicles to clump together. This is thought to be the basis for its effects on acne. For fine wrinkles, the mechanism involves changes in gene expression and epithelial cell behavior, though the precise chain of events is not fully established. Very little of the applied dose is absorbed into the bloodstream — blood levels after topical use are generally within the normal range for naturally occurring vitamin A metabolites.

🔬Pharmacokinetics — how your body processes it▾

Tretinoin applied to the skin is only minimally absorbed into the body — studies estimate less than 2% of the applied dose reaches the bloodstream, and blood levels remain close to the body's natural baseline for vitamin A-related compounds. Once absorbed, tretinoin binds very strongly to proteins in the blood. It is broken down by liver enzymes (including CYP3A4 and related enzymes) and the breakdown products are cleared through both urine and feces. The elimination half-life — how long it takes the body to clear half of the drug — is short when taken orally in a medical setting, around 0.5 to 2 hours, though topical use results in much lower systemic exposure overall.

📦How to store it▾

Store at controlled room temperature 20° to 25°C (68° to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Protect from freezing. Keep out of reach of children.

📄 Written from Tretinoin’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

52

Supplements & herbs that interact with Tretinoin

52 supplements and herbal products have documented interactions with Tretinoin in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 2
  • Moderate · 37
  • Minor · 13
ACTIVATED CHARCOAL Major VITAMIN A Major AFRICAN WILD POTATO Moderate ALFALFA Moderate ANGELICA ARCHANGELICA Moderate ARRACH Moderate BERGAMOT Moderate BISHOP'S WEED Moderate +44 more
Every supplement checked against Tretinoin — ranked by severity The full interaction hub: 2 major · 37 moderate · 13 minor · every one linked to its full report. Check Tretinoin against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

1

Nutrient depletion considerations

Tretinoin has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

FOLIC ACID Moderate Depletion
See the full Tretinoin nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Tretinoin — the kind of thing our pharmacy team would talk through with you at the counter.

Will tretinoin actually get rid of my wrinkles? ▾
Honestly, it won't erase wrinkles — and the label is pretty direct about that. What it's approved to do is help reduce the appearance of fine wrinkles as part of a full routine that includes sunscreen, moisturizer, and sun protection. Deep lines, rough texture, dark spots, or saggy skin are not things tretinoin is shown to help with. Think of it as one useful tool in a bigger skin care plan, not a cure.
My skin is really red and peeling after the first week — should I stop? ▾
Redness, peeling, and irritation in the first couple of weeks are very common and usually mean your skin is adjusting — not that something is wrong. If it's tolerable, try hanging in there, because it often settles down. If it's severe or you're getting blistering, cut back on how often you apply it and call your doctor. Never apply more to try to push through it faster — that'll make irritation worse, not better.
Do I really need sunscreen every day while using this? ▾
Yes — this one isn't optional. Tretinoin makes your skin noticeably more sensitive to sunlight, which means you can burn much more easily than usual. Use a sunscreen with at least SPF 15 every single day, wear protective clothing when you're outside, and skip the tanning bed entirely. If you're already sunburned, wait until your skin is fully healed before applying tretinoin again.
Can I use my regular acne products or toners at the same time? ▾
Be careful here. Products with benzoyl peroxide, salicylic acid, sulfur, or resorcinol — common in OTC acne treatments — can really amp up irritation when used alongside tretinoin. Same goes for strong astringents, alcohol-heavy toners, and abrasive scrubs. It's best to let those effects settle before you start tretinoin, and talk to your pharmacist or doctor about what's safe to layer. Gentle, non-medicated cleansers and a basic moisturizer are your best friends right now.
Is tretinoin safe to use if I'm pregnant or trying to conceive? ▾
This is a conversation to have with your doctor before continuing use. Human data from topical tretinoin haven't shown a clear link to birth defects, but animal studies at high doses did show fetal abnormalities. Because so little is absorbed through the skin, the risk from topical use appears low — but it hasn't been fully ruled out. Your prescriber can help you weigh the risks and benefits for your specific situation.
How long before I actually see results? ▾
Patience is key here. You might notice some early changes around two weeks in, but it typically takes more than seven weeks of consistent use to see real, reliable improvement in fine wrinkles. And it only works as long as you're using it as part of a full skin care routine — sunscreen, moisturizer, and all. Also worth knowing: safety and effectiveness beyond 52 weeks of daily use haven't been fully established, so keep your doctor in the loop if you're using it long-term.
Is Tretinoin available over the counter? ▾
Tretinoin is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Tretinoin first available? ▾
Tretinoin has been available in the United States since at least 1971, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Tretinoin? ▾
Tretinoin is supplied by 52 manufacturers listed in the FDA NDC Directory, including Padagis US LLC, Mylan Pharmaceuticals Inc., Bausch Health US LLC.

💬 Answers drafted from Tretinoin’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

📊Tretinoin supplement interactions52 checked — ranked by severity 🌿Drug & Supplement CheckerTretinoin vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Tretinoin NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Tretinoin comes

Tretinoin is available in 2 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Capsule

By mouth
Available strengths 1 strength
10 mg
23 FDA-listed product records ⓘ

📊 Tretinoin across the U.S. market

How Tretinoin appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

2
Dose forms ⓘ
52
Manufacturers
9
Brand names
194
FDA-listed product records ⓘ
1971
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (18) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Padagis US LLC11%
Mylan Pharmaceuticals Inc.9%
Bausch Health US LLC8%
Bryant Ranch Prepack8%
A-S Medication Solutions7%
Bausch Health US, LLC7%
Other makers50%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Tretinoin is used

A general measure of how commonly Tretinoin is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Tretinoin is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

1,345,058
Medicaid prescriptions filled (Q1–Q4 2025)
$69.1M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Tretinoin prescribed? Of the 1,596 medications we measure, Tretinoin ranks #138 by Medicaid prescriptions — more than 91% of them.

Where Tretinoin ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #138 of 1,596
#133 Glipizide 1,400,626 Rx #134 Buprenorphine Buccal (... 1,379,027 Rx #135 Buprenorphine 1,379,027 Rx #136 Chlorhexidine 1,373,852 Rx #137 Simvastatin 1,357,663 Rx #138 Tretinoin 1,345,058 Rx #139 Tretinoin Topical 1,344,781 Rx #140 Dapagliflozin 1,339,664 Rx #141 Benztropine 1,314,428 Rx #142 Diphenhydramine 1,303,409 Rx #143 Dexamethasone Injectio... 1,290,031 Rx

Utilization by Tretinoin product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 0.25 mg/mL topical cream is the most-dispensed Tretinoin product — about 50% of these Medicaid prescriptions.

tretinoin 0.25 MG/ML Topical Cream Most dispensed

675,435 Medicaid prescriptions (Q1–Q4 2025) 50% of Tretinoin prescriptions shown $23.9M gross reimbursement (before rebates) ≈ $35 per prescription (gross)

Summed across the 14 of 30 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 106302

tretinoin 0.5 MG/ML Topical Cream

384,214 Medicaid prescriptions (Q1–Q4 2025) 29% of Tretinoin prescriptions shown $18.2M gross reimbursement (before rebates) ≈ $47 per prescription (gross)

Summed across the 10 of 19 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 106303

tretinoin 1 MG/ML Topical Cream

181,320 Medicaid prescriptions (Q1–Q4 2025) 13% of Tretinoin prescriptions shown $9.1M gross reimbursement (before rebates) ≈ $50 per prescription (gross)

Summed across the 14 of 33 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 198300

tretinoin 0.00025 MG/MG Topical Gel

41,772 Medicaid prescriptions (Q1–Q4 2025) 3% of Tretinoin prescriptions shown $3.1M gross reimbursement (before rebates) ≈ $74 per prescription (gross)

Summed across the 6 of 15 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313451

tretinoin 0.0001 MG/MG Topical Gel

37,977 Medicaid prescriptions (Q1–Q4 2025) 3% of Tretinoin prescriptions shown $2.7M gross reimbursement (before rebates) ≈ $72 per prescription (gross)

Summed across the 6 of 15 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313450

tretinoin 0.0008 MG/MG Topical Gel

11,120 Medicaid prescriptions (Q1–Q4 2025) <1% of Tretinoin prescriptions shown $7.8M gross reimbursement (before rebates) ≈ $704 per prescription (gross)

Summed across the 4 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1488045

tretinoin 0.0005 MG/MG Topical Gel

7,122 Medicaid prescriptions (Q1–Q4 2025) <1% of Tretinoin prescriptions shown $1.8M gross reimbursement (before rebates) ≈ $258 per prescription (gross)

Summed across the 2 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 245723

tretinoin 0.0004 MG/MG Topical Gel

3,962 Medicaid prescriptions (Q1–Q3 2025) <1% of Tretinoin prescriptions shown $1.5M gross reimbursement (before rebates) ≈ $376 per prescription (gross)

Summed across the 3 of 14 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 359050

tretinoin 0.001 MG/MG Topical Gel

1,029 Medicaid prescriptions (Q1–Q4 2025) <1% of Tretinoin prescriptions shown $316,747 gross reimbursement (before rebates) ≈ $308 per prescription (gross)

Summed across the 3 of 12 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313453

tretinoin 0.5 MG/ML Topical Lotion

736 Medicaid prescriptions (Q1–Q4 2025) <1% of Tretinoin prescriptions shown $71,763 gross reimbursement (before rebates) ≈ $98 per prescription (gross)

Summed across the 2 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 250939

tretinoin 10 MG Oral Capsule

277 Medicaid prescriptions (Q1–Q4 2025) <1% of Tretinoin prescriptions shown $511,282 gross reimbursement (before rebates) ≈ $1,846 per prescription (gross)

Summed across the 2 of 16 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 199159

tretinoin 0.0006 MG/MG Topical Gel

94 Medicaid prescriptions (Q1–Q4 2025) <1% of Tretinoin prescriptions shown $82,591 gross reimbursement (before rebates) ≈ $879 per prescription (gross)

Summed across the 1 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1987644

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Tretinoin, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 67 of 174 listed Tretinoin NDCs with Medicaid activity.

🔍 Compare Tretinoin products

A representative set of FDA-listed product records for Tretinoin — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 194 of 194 products — FDA National Drug Code Directory. See every product, package size and price: browse all 194 Tretinoin NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Tretinoin RxCUI 10753 5 dose forms · 17 strengths
  1. Dose form (SCDF) Oral Capsule RxCUI 374187 In current FDA listings
    Clinical drug / strength (SCD) 10 MG RxCUI 199159
  2. Dose form (SCDF) Topical Cream RxCUI 377828 In current FDA listings
    Clinical drug / strength (SCD) Emollient tretinoin 0.5 MG/ML RxCUI 2117659 0.2 MG/ML RxCUI 252265 0.25 MG/ML RxCUI 106302 0.375 MG/ML RxCUI 997641 0.5 MG/ML RxCUI 106303 1 MG/ML RxCUI 198300
  4. Dose form (SCDF) Topical Lotion RxCUI 379379 In current FDA listings
    Clinical drug / strength (SCD) 0.25 MG/ML RxCUI 106304 0.5 MG/ML RxCUI 250939
  5. Dose form (SCDF) Topical Solution RxCUI 374188 No current FDA listing
    Clinical drug / strength (SCD) 0.5 MG/ML RxCUI 313452

Look up RxCUI 10753 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Vesanoid Retin-A Altreno Avita Atralin Renova Refissa Tretin X Retin-A MICRO

🏭 Manufacturers & labelers

Padagis US LLC 20 Mylan Pharmaceuticals Inc. 17 Bausch Health US LLC 14 Bryant Ranch Prepack 14 A-S Medication Solutions 13 Bausch Health US, LLC 13 Oceanside Pharmaceuticals 10 Obagi Cosmeceuticals LLC 8 Encube Ethicals, Inc. 7 NuCare Pharmaceuticals,Inc. 5 Northstar Rx Llc 5 Remedyrepack Inc. 4 Sun Pharmaceutical Industries, Inc. 3 Glenmark Pharmaceuticals Inc., USA 3 Taro Pharmaceuticals U.S.A., Inc. 3 Alembic Pharmaceuticals Limited 3 Alembic Pharmaceuticals Inc. 3 American Health Packaging 2 NuCare Pharmaceuticals, Inc. 2 Teva Pharmaceuticals USA, Inc. 2 Catalent Germany Eberbach GmbH 2 RPK Pharmaceuticals, Inc. 2 Major Pharmaceuticals 2 Olon SpA 2

…and 16 more on the FDA NDC directory.

RxNorm drug class

Tretinoin belongs to the Retinoid class.

Pharmacologic class Retinoid
Drug family (ATC) Retinoids for topical use in acne, Retinoids for cancer treatment

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Apr 16, 2026
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Tretinoin.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Tretinoin after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
56
NDC products indexed
194
Distinct labelers/manufacturers represented
52
Linked representative label ⓘ
Encube Ethicals, Inc.
Linked label effective
Apr 16, 2026
Composite sections available
24
Linked SPL Set ID
57558405-42fa-40bb-a61c-48e030d976de
Linked SPL Document ID
8cc4690a-be86-4f4a-8bd1-ff9f5d5d5747
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 2

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 56 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Encube Ethicals, Inc. is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.