Tretinoin

Generic name: Pronounced as (tret' i noe in)
Brand names
  • Vesanoid®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 09/15/2016

Tretinoin may cause severe side effects. Tretinoin should be given only under the supervision of a doctor who has experience in treating people who have leukemia (cancer of the white blood cells) and in a hospital where patients can be monitored for severe side effects and treated if these side effects occur.

Tretinoin may cause a serious or life-threatening group of symptoms called retinoic acid-APL(RA-APL) syndrome. Your doctor will monitor you carefully to see whether you are developing this syndrome. If you experience any of the following symptoms, call your doctor immediately: fever; weight gain; swelling of the arms, hands, feet, ankles, or lower legs; shortness of breath; labored breathing; wheezing; chest pain; or cough. At the first sign that you are developing RA-APL syndrome, your doctor will prescribe one or more medications to treat the syndrome.

Tretinoin may cause a rapid increase in the number of white blood cells in the body. This is associated with a higher risk of life-threatening side effects. If you have a very high number of white blood cells before you begin tretinoin treatment, or if you have an increase in the number of white blood cells during your treatment with tretinoin, expecially if you experience any of the symptoms of RA-APL syndrome, your doctor may prescribe one or more medications to treat or prevent the increase in white blood cells.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to tretinoin.

Talk to your doctor about the risk(s) of taking tretinoin.

For female patients:

Tretinoin must not be taken by patients who are pregnant or who may become pregnant. There is a high risk that tretinoin will cause the baby to be born with birth defects (physical problems that are present at birth).

If you can become pregnant, you will need to avoid pregnancy during your treatment with tretinoin. You must use two acceptable forms of birth control during your treatment and for 1 month after your treatment, even if you have infertility (difficulty becoming pregnant) or have experienced menopause ('change of life'; end of monthly menstrual periods). You must use these two forms of birth control at all times unless you can promise that you will not have any sexual contact with a male for 1 month after your treatment. Your doctor will tell you which forms of birth control are acceptable, and will give you full information about birth control.

If you plan to use oral contraceptives (birth control pills) while taking tretinoin, tell your doctor the name of the pill you will use. Microdosed progestin ('minipill') oral contraceptives (Ovrette, Micronor, Nor-D) may not be an effective form of birth control for people who are taking tretinoin.

You must have a negative pregnancy test within 1 week before you begin to take tretinoin. You will also need to be tested for pregnancy in a laboratory each month during your treatment. Tell your doctor immediately if you think you might be pregnant at any time during your treatment with tretinoin.

Tretinoin is used to treat acute promyelocytic leukemia (APL; a type of cancer in which there are too many immature blood cells in the blood and bone marrow) in people who have not been helped by other types of chemotherapy or whose condition has improved but then worsened following treatment with other types of chemotherapy. Tretinoin is used to produce remission (a decrease or disappearance of signs and symptoms of cancer) of APL, but other medications must be used after treatment with tretinoin to prevent the cancer from returning. Tretinoin is in a class of medications called retinoids. It works by slowing or stopping the growth of cancer cells by causing immature blood cells to develop into normal blood cells.

Tretinoin comes as a capsule to take by mouth. It is usually taken twice a day for up to 90 days. Take tretinoin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tretinoin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take tretinoin even if you feel well. Do not stop taking tretinoin without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking tretinoin,

  • tell your doctor and pharmacist if you are allergic to tretinoin, other retinoids such as acitretin (Soriatane), etretinate (Tegison), bexarotene, or isotretinoin (Accutane, Claravis, Sotret), any other medications, parabens (a preservative), or any of the other ingredients in tretinoin capsules. Ask your doctor or pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminocaproic acid (Amicar); certain calcium channel blockers such as diltiazem (Cardizem, Dilacor, Tiazac, others) and verapamil (Calan, Covera, Isoptin, Verelan); cimetidine (Tagamet); cyclosporine (Sandimmune, Gengraf, Neoral); erythromycin (E.E.S., Erythrocin, E-Mycin); hydroxyurea (Droxia); ketoconazole (Nizoral); pentobarbital; phenobarbital; rifampin (Rifadin, Rimactane);oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); tetracycline antibiotics such as demeclocycline (Declomycin), doxycycline (Monodox, Vibramycin, others), minocycline (Minocin), oxytetracycline (Terramycin), and tetracycline (Sumycin, Tetrex, others); tranexamic acid (Cyklokapron); and vitamin A. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with tretinoin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you have or have ever had increased amounts of cholesterol (a fat-like substance) and other fatty substances in the blood, or liver or heart disease.

  • tell your doctor if you are breast-feeding.

  • if you will be having surgery, including dental surgery, tell your doctor or dentist that you are taking tretinoin.

  • you should know that tretinoin may cause dizziness or severe headache.Do not drive a car or operate machinery until you know how this medication affects you.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Tretinoin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • weakness

    • extreme tiredness

    • shivering

    • pain

    • earache

    • feeling of fullness in the ears

    • dry skin

    • rash

    • hair loss

    • constipation

    • diarrhea

    • stomach pain

    • heartburn

    • loss of appetite

    • weight loss

    • bone pain

    • dizziness

    • numbness, burning, or tingling in the hands or feet

    • nervousness

    • depression

    • difficulty falling asleep or staying asleep

    • confusion

    • agitation

    • hallucinating (seeing things or hearing voices that do not exist)

    • difficulty urinating

    • flushing

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

    • headache

    • nausea

    • vomiting

    • blurred or double vision, or other vision problems

    • unusual bruising or bleeding

    • vomit that is bloody or looks like coffee grounds

    • bright red or black and tarry stools

    • irregular heartbeat

    • hearing loss

    • bleeding

    • infections

  • Tretinoin may increase the levels of cholesterol and other fats in your blood and may stop your liver from working normally. Your doctor will monitor you carefully to see whether you are experiencing either of these side effects.

  • Tretinoin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • headache

  • flushing

  • red, cracked, and sore lips

  • stomach pain

  • dizziness

  • loss of coordination

Do not let anyone else take your medication. Ask your pharmacist if you have any questions about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Repaglinide can be decreased when combined with Tretinoin.
Montelukast Montelukast The metabolism of Tretinoin can be decreased when combined with Montelukast.
Leflunomide Leflunomide The risk or severity of adverse effects can be increased when Tretinoin is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Tretinoin can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Tretinoin can be increased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Tretinoin.
Candesartan Candesartan The metabolism of Tretinoin can be decreased when combined with Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Tretinoin.
Clopidogrel Clopidogrel The metabolism of Tretinoin can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Tretinoin can be decreased when combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Tretinoin can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Tretinoin is combined with Guanfacine.
Mycophenolate Mycophenolate The risk or severity of adverse effects can be increased when Tretinoin is combined with Mycophenolic acid.
Paregoric Paregoric The metabolism of Tretinoin can be decreased when combined with Morphine.
Penbutolol Penbutolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Acebutolol.
Prednisone Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Tretinoin.
Reserpine Reserpine The metabolism of Tretinoin can be increased when combined with Reserpine.
Tacrolimus Tacrolimus Tacrolimus may increase the immunosuppressive activities of Tretinoin.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Tretinoin.
Triamcinolone Triamcinolone The risk or severity of adverse effects can be increased when Triamcinolone is combined with Tretinoin.
Doxycycline Injection Doxycycline Injection The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The metabolism of Tretinoin can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Tretinoin can be decreased when combined with Hydromorphone.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Tretinoin.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Tretinoin.
Meperidine Injection Meperidine Injection The metabolism of Tretinoin can be decreased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Methylprednisolone.
Metronidazole Injection Metronidazole Injection The metabolism of Tretinoin can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Tretinoin can be decreased when combined with Morphine.
Zidovudine Injection Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Tretinoin.
Altretamine Altretamine Amphetamine may increase the orthostatic hypotensive activities of Tretinoin.
Cyclosporine Cyclosporine Tretinoin may increase the immunosuppressive activities of Cyclosporine.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Tretinoin.
Torsemide Torsemide The metabolism of Tretinoin can be decreased when combined with Torasemide.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Tretinoin.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Tretinoin.
Eprosartan Eprosartan The risk or severity of adverse effects can be increased when Tretinoin is combined with Eprosartan.
Hydroxychloroquine Hydroxychloroquine The risk or severity of adverse effects can be increased when Tretinoin is combined with Hydroxychloroquine.
Meloxicam Meloxicam The metabolism of Meloxicam can be decreased when combined with Tretinoin.
Orlistat Orlistat Orlistat can cause a decrease in the absorption of Tretinoin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxcarbazepine Oxcarbazepine The metabolism of Tretinoin can be increased when combined with Oxcarbazepine.
Telmisartan Telmisartan The risk or severity of adverse effects can be increased when Tretinoin is combined with Telmisartan.
Temozolomide Temozolomide The risk or severity of adverse effects can be increased when Tretinoin is combined with Temozolomide.
Zaleplon Zaleplon The metabolism of Zaleplon can be decreased when combined with Tretinoin.
Anakinra Anakinra The metabolism of Tretinoin can be increased when combined with Anakinra.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Tretinoin.
Trimipramine Trimipramine The metabolism of Tretinoin can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Tretinoin can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Tretinoin can be increased when combined with Modafinil.
Perindopril Perindopril The risk or severity of adverse effects can be increased when Tretinoin is combined with Perindopril.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Tretinoin.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Tretinoin.
Epinephrine Injection Epinephrine Injection The metabolism of Tretinoin can be decreased when combined with Epinephrine.
Epirubicin Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Tretinoin.
Eplerenone Eplerenone The metabolism of Tretinoin can be decreased when combined with Eplerenone.
Olmesartan Olmesartan The risk or severity of adverse effects can be increased when Tretinoin is combined with Olmesartan.
Zonisamide Zonisamide The metabolism of Zonisamide can be decreased when combined with Tretinoin.
Adalimumab Injection Adalimumab Injection The metabolism of Tretinoin can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Tretinoin.
Glatiramer Injection Glatiramer Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Glatiramer.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Tretinoin.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Tretinoin.
Eletriptan Eletriptan The metabolism of Tretinoin can be increased when combined with Eletriptan.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Tretinoin.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Tretinoin.
Aprepitant Aprepitant The metabolism of Tretinoin can be decreased when combined with Aprepitant.
Memantine Memantine The metabolism of Tretinoin can be decreased when combined with Memantine.
Tegaserod Tegaserod The metabolism of Tretinoin can be decreased when combined with Tegaserod.
Tadalafil Tadalafil The metabolism of Tadalafil can be decreased when combined with Tretinoin.
Progesterone Progesterone The metabolism of Tretinoin can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Tretinoin can be decreased when combined with Apomorphine.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Tretinoin.
Infliximab Injection Infliximab Injection The metabolism of Tretinoin can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Tretinoin can be decreased when combined with Oxandrolone.
Rifaximin Rifaximin The metabolism of Tretinoin can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Tretinoin is combined with Duloxetine.
Norethindrone Norethindrone The therapeutic efficacy of Norethisterone can be decreased when used in combination with Tretinoin.
Bosentan Bosentan The metabolism of Tretinoin can be increased when combined with Bosentan.
Natalizumab Injection Natalizumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Natalizumab.
Erlotinib Erlotinib The metabolism of Tretinoin can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Tretinoin can be decreased when combined with Eszopiclone.
Voriconazole Voriconazole The metabolism of Tretinoin can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the orthostatic hypotensive activities of Tretinoin.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Tretinoin.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Tretinoin.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the orthostatic hypotensive activities of Tretinoin.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Tretinoin.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Tretinoin.
Deferasirox Deferasirox The metabolism of Tretinoin can be decreased when combined with Deferasirox.
Felbamate Felbamate The metabolism of Tretinoin can be decreased when combined with Felbamate.
Abatacept Injection Abatacept Injection The metabolism of Tretinoin can be increased when combined with Abatacept.
Rasagiline Rasagiline Rasagiline may increase the orthostatic hypotensive activities of Tretinoin.
Imatinib Imatinib The risk or severity of adverse effects can be increased when Imatinib is combined with Tretinoin.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Tretinoin.
Bevacizumab Injection Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Tretinoin.
Gefitinib Gefitinib The metabolism of Tretinoin can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The metabolism of Paliperidone can be decreased when combined with Tretinoin.
Bortezomib Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Tretinoin.
Clofarabine Injection Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Tretinoin.
Hepatitis B Vaccine Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Tretinoin.
Influenza Vaccine, Inactivated or Recombinant Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Tretinoin.
Influenza Vaccine, Live Intranasal Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Tretinoin.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Tretinoin.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Tretinoin.
Rituximab Injection Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Tretinoin.
Aliskiren Aliskiren The risk or severity of adverse effects can be increased when Tretinoin is combined with Aliskiren.
Pemetrexed Injection Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Tretinoin.
Nabilone Nabilone The metabolism of Tretinoin can be decreased when combined with Nabilone.
Vorinostat Vorinostat The risk or severity of adverse effects can be increased when Tretinoin is combined with Vorinostat.
Sorafenib Sorafenib The metabolism of Tretinoin can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Tretinoin.
Dronabinol Dronabinol The metabolism of Tretinoin can be decreased when combined with Dronabinol.
Lapatinib Lapatinib The metabolism of Tretinoin can be decreased when combined with Lapatinib.
Verteporfin Injection Verteporfin Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Verteporfin.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Tretinoin.
Mexiletine Mexiletine The metabolism of Tretinoin can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Tretinoin can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Azacitidine.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Tretinoin.
Nelarabine Injection Nelarabine Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Nelarabine.
Lenalidomide Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Tretinoin.
Nilotinib Nilotinib The risk or severity of adverse effects can be increased when Tretinoin is combined with Nilotinib.
Bexarotene Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Tretinoin.
Budesonide Budesonide The risk or severity of adverse effects can be increased when Budesonide is combined with Tretinoin.
Chloramphenicol Injection Chloramphenicol Injection The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Tretinoin.
Decitabine Injection Decitabine Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Decitabine.
Etravirine Etravirine The metabolism of Tretinoin can be decreased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Arsenic trioxide.
Mitoxantrone Injection Mitoxantrone Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Mitoxantrone.
Aminocaproic Acid Aminocaproic Acid The risk or severity of Thrombosis can be increased when Tretinoin is combined with Aminocaproic acid.
Nebivolol Nebivolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Nebivolol.
Bendamustine Injection Bendamustine Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Bendamustine.
Pilocarpine Pilocarpine The metabolism of Tretinoin can be decreased when combined with Pilocarpine.
Flecainide Flecainide The metabolism of Tretinoin can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Tretinoin can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Ixabepilone.
Irinotecan Injection Irinotecan Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Irinotecan.
Estramustine Estramustine The risk or severity of adverse effects can be increased when Tretinoin is combined with Estramustine.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Tretinoin.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Tretinoin.
Midazolam Midazolam The metabolism of Tretinoin can be decreased when combined with Midazolam.
Dexrazoxane Injection Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Tretinoin.
Eltrombopag Eltrombopag The metabolism of Tretinoin can be decreased when combined with Eltrombopag.
Ibritumomab Injection Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Tretinoin.
Betaxolol Betaxolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Betaxolol.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Tretinoin.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Tretinoin.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Tretinoin.
Everolimus Everolimus The risk or severity of adverse effects can be increased when Tretinoin is combined with Everolimus.
Dronedarone Dronedarone The metabolism of Tretinoin can be decreased when combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Pralatrexate.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Tretinoin.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Tretinoin.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Tretinoin.
Topotecan Topotecan The risk or severity of adverse effects can be increased when Tretinoin is combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Tretinoin can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Tretinoin.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Tretinoin.
Levonorgestrel Levonorgestrel The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Tretinoin.
Denosumab Injection Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Tretinoin.
Tocilizumab Injection Tocilizumab Injection The metabolism of Tretinoin can be increased when combined with Tocilizumab.
Fingolimod Fingolimod Tretinoin may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Eribulin.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Tretinoin.
Acetaminophen Injection Acetaminophen Injection The metabolism of Tretinoin can be decreased when combined with Acetaminophen.
Denileukin Diftitox Injection Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Tretinoin.
Sipuleucel-T Injection Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Tretinoin.
Belimumab Injection Belimumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Belimumab.
Azilsartan Azilsartan The risk or severity of adverse effects can be increased when Tretinoin is combined with Azilsartan medoxomil.
Busulfan Injection Busulfan Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Busulfan.
Roflumilast Roflumilast Roflumilast may increase the immunosuppressive activities of Tretinoin.
Rilpivirine Rilpivirine The metabolism of Tretinoin can be decreased when combined with Rilpivirine.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Tretinoin can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Tretinoin can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Tretinoin.
Ticagrelor Ticagrelor The metabolism of Tretinoin can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The risk or severity of adverse effects can be increased when Tretinoin is combined with Ruxolitinib.
Clobazam Clobazam The metabolism of Tretinoin can be decreased when combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Tretinoin can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Tretinoin can be decreased when combined with Vismodegib.
Belatacept Injection Belatacept Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Belatacept.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Tretinoin.
Basiliximab Injection Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Tretinoin.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Tretinoin.
Crizotinib Crizotinib The metabolism of Tretinoin can be decreased when combined with Crizotinib.
Melphalan Injection Melphalan Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Melphalan.
Tranexamic Acid Tranexamic Acid The risk or severity of Thrombosis can be increased when Tretinoin is combined with Tranexamic acid.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Tretinoin.
Eculizumab Injection Eculizumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Eculizumab.
Pertuzumab Injection Pertuzumab Injection The risk or severity of cardiotoxicity can be increased when Tretinoin is combined with Pertuzumab.
Carfilzomib Injection Carfilzomib Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Carfilzomib.
Iloprost Iloprost The risk or severity of adverse effects can be increased when Tretinoin is combined with Iloprost.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be decreased when combined with Tretinoin.
Regorafenib Regorafenib The metabolism of Tretinoin can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The risk or severity of adverse effects can be increased when Tretinoin is combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Corticotropin.
Teriflunomide Teriflunomide The risk or severity of adverse effects can be increased when Tretinoin is combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Tretinoin.
Tofacitinib Tofacitinib Tretinoin may increase the immunosuppressive activities of Tofacitinib.
Dimethyl Fumarate Dimethyl Fumarate The risk or severity of adverse effects can be increased when Tretinoin is combined with Dimethyl fumarate.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Tretinoin.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Tretinoin is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Tretinoin.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Tretinoin.
Canagliflozin Canagliflozin The risk or severity of adverse effects can be increased when Tretinoin is combined with Canagliflozin.
Methazolamide Methazolamide The risk or severity of adverse effects can be increased when Methazolamide is combined with Tretinoin.
Dabrafenib Dabrafenib The metabolism of Tretinoin can be decreased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Tretinoin.
Trametinib Trametinib The metabolism of Tretinoin can be decreased when combined with Trametinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Tretinoin.
Tigecycline Injection Tigecycline Injection The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Tigecycline.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Tretinoin.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Tretinoin.
Ibrutinib Ibrutinib The risk or severity of adverse effects can be increased when Tretinoin is combined with Ibrutinib.
Avanafil Avanafil The risk or severity of hypotension can be increased when Avanafil is combined with Tretinoin.
Ketorolac Injection Ketorolac Injection The metabolism of Tretinoin can be decreased when combined with Ketorolac.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Obinutuzumab.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Tretinoin.
Apremilast Apremilast The metabolism of Tretinoin can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Tretinoin can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Tretinoin can be increased when combined with Siltuximab.
Vedolizumab Injection Vedolizumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Vedolizumab.
Belinostat Injection Belinostat Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Belinostat.
Idelalisib Idelalisib The risk or severity of adverse effects can be increased when Tretinoin is combined with Idelalisib.
Testosterone Injection Testosterone Injection The metabolism of Tretinoin can be decreased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Tretinoin can be decreased when combined with Oritavancin.
Empagliflozin Empagliflozin The risk or severity of adverse effects can be increased when Tretinoin is combined with Empagliflozin.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Tretinoin.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Tretinoin.
Blinatumomab Injection Blinatumomab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Blinatumomab.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Tretinoin.
Pirfenidone Pirfenidone The risk or severity of adverse effects can be increased when Tretinoin is combined with Pirfenidone.
Secukinumab Injection Secukinumab Injection The metabolism of Tretinoin can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection Tretinoin may increase the hypotensive activities of Risperidone.
Palbociclib Palbociclib The risk or severity of adverse effects can be increased when Tretinoin is combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Tretinoin can be decreased when combined with Lenvatinib.
Panobinostat Panobinostat The risk or severity of adverse effects can be increased when Tretinoin is combined with Panobinostat.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Dinutuximab.
Haloperidol Injection Haloperidol Injection The serum concentration of Tretinoin can be increased when it is combined with Haloperidol.
Amiloride Amiloride The risk or severity of adverse effects can be increased when Amiloride is combined with Tretinoin.
Macitentan Macitentan Tretinoin may increase the hypotensive activities of Macitentan.
Prednisolone Prednisolone The risk or severity of adverse effects can be increased when Tretinoin is combined with Prednisolone.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Tretinoin.
Ziprasidone Injection Ziprasidone Injection The metabolism of Tretinoin can be decreased when combined with Ziprasidone.
Mepolizumab Injection Mepolizumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Mepolizumab.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Tretinoin.
Rifapentine Rifapentine The metabolism of Tretinoin can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Tretinoin.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of adverse effects can be increased when Amphotericin B is combined with Tretinoin.
Dexamethasone Injection Dexamethasone Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Dexamethasone.
Ixekizumab Injection Ixekizumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Ixekizumab.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Tretinoin.
Cobicistat Cobicistat The metabolism of Tretinoin can be decreased when combined with Cobicistat.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Tretinoin.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Tretinoin.
Furosemide Injection Furosemide Injection The risk or severity of adverse effects can be increased when Furosemide is combined with Tretinoin.
Rucaparib Rucaparib The metabolism of Tretinoin can be decreased when combined with Rucaparib.
Brodalumab Injection Brodalumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Brodalumab.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Tretinoin.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Tretinoin.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Tretinoin.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Tretinoin.
Deflazacort Deflazacort The risk or severity of adverse effects can be increased when Tretinoin is combined with Deflazacort.
Safinamide Safinamide Safinamide may increase the orthostatic hypotensive activities of Tretinoin.
Ocrelizumab Injection Ocrelizumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Ocrelizumab.
Sarilumab Injection Sarilumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Tretinoin can be increased when combined with Midostaurin.
Guselkumab Injection Guselkumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Guselkumab.
Enasidenib Enasidenib The metabolism of Tretinoin can be decreased when combined with Enasidenib.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Tretinoin.
Delafloxacin Delafloxacin The metabolism of Tretinoin can be increased when combined with Delafloxacin.
Acalabrutinib Acalabrutinib The metabolism of Tretinoin can be decreased when combined with Acalabrutinib.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Tretinoin.
Letermovir Letermovir The metabolism of Tretinoin can be decreased when combined with Letermovir.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Tretinoin.
Apalutamide Apalutamide The metabolism of Tretinoin can be decreased when combined with Apalutamide.
Penicillamine Penicillamine The risk or severity of adverse effects can be increased when Tretinoin is combined with Penicillamine.
Fostamatinib Fostamatinib The risk or severity of hypotension can be increased when Fostamatinib is combined with Tretinoin.
Avatrombopag Avatrombopag The metabolism of Tretinoin can be increased when combined with Avatrombopag.
Baricitinib Baricitinib The risk or severity of adverse effects can be increased when Tretinoin is combined with Baricitinib.
Lofexidine Lofexidine The risk or severity of adverse effects can be increased when Tretinoin is combined with Lofexidine.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Tretinoin.
Eravacycline Injection Eravacycline Injection The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Eravacycline.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Tretinoin.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Tretinoin.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Tretinoin.
Omadacycline Omadacycline The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Omadacycline.
Sarecycline Sarecycline The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Tretinoin can be decreased when combined with Stiripentol.
Glasdegib Glasdegib The metabolism of Glasdegib can be decreased when combined with Tretinoin.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Tretinoin.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Tretinoin.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Tretinoin.
Rifamycin Rifamycin The metabolism of Tretinoin can be decreased when combined with Rifamycin.
Ravulizumab-cwvz Injection Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Ravulizumab.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Tretinoin can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Tretinoin.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Tretinoin.
Risankizumab-rzaa Injection Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Risankizumab.
Alpelisib Alpelisib The serum concentration of Tretinoin can be decreased when it is combined with Alpelisib.
Cladribine Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Tretinoin.
Triclabendazole Triclabendazole The metabolism of Tretinoin can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Tretinoin.
Pitolisant Pitolisant The serum concentration of Tretinoin can be decreased when it is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The metabolism of Tretinoin can be decreased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Tretinoin can be decreased when combined with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Tretinoin.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Tretinoin.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Tretinoin.
Cenobamate Cenobamate The serum concentration of Tretinoin can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The risk or severity of adverse effects can be increased when Tretinoin is combined with Ozanimod.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Tretinoin.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Tretinoin.
Selpercatinib Selpercatinib The serum concentration of Tretinoin can be increased when it is combined with Selpercatinib.
Lemborexant Lemborexant The serum concentration of Tretinoin can be decreased when it is combined with Lemborexant.
Pralsetinib Pralsetinib The metabolism of Tretinoin can be decreased when combined with Pralsetinib.
Opicapone Opicapone The metabolism of Tretinoin can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Tretinoin can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Drospirenone can be decreased when used in combination with Tretinoin.
Theophylline Theophylline The metabolism of Tretinoin can be decreased when combined with Theophylline.
Indomethacin Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Tretinoin.
Mefenamic Acid Mefenamic Acid The metabolism of Tretinoin can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Tretinoin.
Trazodone Trazodone The metabolism of Tretinoin can be decreased when combined with Trazodone.
Hydroxyurea Hydroxyurea The risk or severity of adverse effects can be increased when Tretinoin is combined with Hydroxyurea.
Floxuridine Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Tretinoin.
Phenobarbital Phenobarbital The metabolism of Tretinoin can be decreased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The risk or severity of adverse effects can be increased when Methotrexate is combined with Tretinoin.
Primidone Primidone Tretinoin may increase the hypotensive activities of Primidone.
Chlorpromazine Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Tretinoin.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Tretinoin.
Flurazepam Flurazepam The metabolism of Tretinoin can be decreased when combined with Flurazepam.
Phenoxybenzamine Phenoxybenzamine The risk or severity of adverse effects can be increased when Tretinoin is combined with Phenoxybenzamine.
Carmustine Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Tretinoin.
Bromocriptine Bromocriptine The risk or severity of adverse effects can be increased when Tretinoin is combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Tretinoin can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine Phenelzine may increase the orthostatic hypotensive activities of Tretinoin.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Tretinoin is combined with Procarbazine.
Tetracycline Tetracycline The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Tetracycline.
Thioguanine Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Tretinoin.
Minocycline Minocycline The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Minocycline.
Demeclocycline Demeclocycline The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Demeclocycline.
Thioridazine Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Tretinoin.
Bleomycin Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Tretinoin.
Dapsone Dapsone The metabolism of Tretinoin can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Tretinoin can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone The metabolism of Tretinoin can be decreased when combined with Oxycodone.
Methadone Methadone The metabolism of Tretinoin can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Tretinoin can be decreased when combined with Oxybutynin.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Tretinoin.
Orphenadrine Orphenadrine The metabolism of Tretinoin can be decreased when combined with Orphenadrine.
Azathioprine Azathioprine The risk or severity of adverse effects can be increased when Tretinoin is combined with Azathioprine.
Sulfasalazine Sulfasalazine The risk or severity of adverse effects can be increased when Tretinoin is combined with Sulfasalazine.
Hydrocortisone Hydrocortisone The metabolism of Tretinoin can be increased when combined with Hydrocortisone.
Lomustine Lomustine The risk or severity of adverse effects can be increased when Tretinoin is combined with Lomustine.
Doxorubicin Doxorubicin The risk or severity of adverse effects can be increased when Tretinoin is combined with Doxorubicin.
Cytarabine Cytarabine The risk or severity of adverse effects can be increased when Tretinoin is combined with Cytarabine.
Mechlorethamine Mechlorethamine The risk or severity of adverse effects can be increased when Tretinoin is combined with Mechlorethamine.
Dactinomycin Dactinomycin The risk or severity of adverse effects can be increased when Tretinoin is combined with Dactinomycin.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Tretinoin.
Methyldopa Methyldopa The risk or severity of adverse effects can be increased when Tretinoin is combined with Methyldopa.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Tretinoin.
Prazosin Prazosin The risk or severity of adverse effects can be increased when Tretinoin is combined with Prazosin.
Hydralazine Hydralazine The risk or severity of adverse effects can be increased when Tretinoin is combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Tretinoin can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Tretinoin can be decreased when combined with Warfarin.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Tretinoin.
Promethazine Promethazine The metabolism of Promethazine can be decreased when combined with Tretinoin.
Daunorubicin Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Tretinoin.
Griseofulvin Griseofulvin The metabolism of Tretinoin can be increased when combined with Griseofulvin.
Digoxin Digoxin Digoxin may decrease the cardiotoxic activities of Tretinoin.
Chloroquine Chloroquine The metabolism of Tretinoin can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Tretinoin can be decreased when combined with Quinine.
Triamterene Triamterene The risk or severity of adverse effects can be increased when Triamterene is combined with Tretinoin.
Sulfinpyrazone Sulfinpyrazone The metabolism of Tretinoin can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The risk or severity of adverse effects can be increased when Tretinoin is combined with Chlorothiazide.
Chlorthalidone Chlorthalidone The risk or severity of adverse effects can be increased when Tretinoin is combined with Chlorthalidone.
Metolazone Metolazone The risk or severity of adverse effects can be increased when Tretinoin is combined with Metolazone.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Tretinoin.
Secobarbital Secobarbital The metabolism of Tretinoin can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Tretinoin.
Amitriptyline Amitriptyline The metabolism of Tretinoin can be decreased when combined with Amitriptyline.
Imipramine Imipramine The metabolism of Tretinoin can be decreased when combined with Imipramine.
Probenecid Probenecid The metabolism of Tretinoin can be increased when combined with Probenecid.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Tretinoin.
Isoniazid Isoniazid The metabolism of Tretinoin can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Tretinoin can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid Valproic acid may increase the Pseudotumor Cerebri activities of Tretinoin.
Tamoxifen Tamoxifen The metabolism of Tretinoin can be decreased when combined with Tamoxifen.
Mitomycin Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Tretinoin.
Butabarbital Butabarbital Butabarbital may increase the hypotensive activities of Tretinoin.
Levothyroxine Levothyroxine The metabolism of Tretinoin can be decreased when combined with Levothyroxine.
Methimazole Methimazole The risk or severity of adverse effects can be increased when Tretinoin is combined with Methimazole.
Propylthiouracil Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Tretinoin.
Chlorpropamide Chlorpropamide The metabolism of Tretinoin can be decreased when combined with Chlorpropamide.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Tretinoin.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Tretinoin.
Dextromethorphan Dextromethorphan The metabolism of Tretinoin can be decreased when combined with Dextromethorphan.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Tretinoin.
Brompheniramine Brompheniramine The metabolism of Brompheniramine can be decreased when combined with Tretinoin.
Methyclothiazide Methyclothiazide The risk or severity of adverse effects can be increased when Methyclothiazide is combined with Tretinoin.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of adverse effects can be increased when Tretinoin is combined with Hydrochlorothiazide.
Chlorzoxazone Chlorzoxazone The metabolism of Tretinoin can be decreased when combined with Chlorzoxazone.
Disulfiram Disulfiram The metabolism of Disulfiram can be decreased when combined with Tretinoin.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Tretinoin can be decreased when combined with Propranolol.
Minoxidil Minoxidil The risk or severity of adverse effects can be increased when Tretinoin is combined with Minoxidil.
Spironolactone Spironolactone The metabolism of Tretinoin can be decreased when combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection The risk or severity of adverse effects can be increased when Amphotericin B is combined with Tretinoin.
Mercaptopurine Mercaptopurine The risk or severity of adverse effects can be increased when Tretinoin is combined with Mercaptopurine.
Nadolol Nadolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Nadolol.
Papaverine Papaverine The risk or severity of adverse effects can be increased when Tretinoin is combined with Papaverine.
Fluorouracil Injection Fluorouracil Injection The metabolism of Tretinoin can be decreased when combined with Fluorouracil.
Colchicine Colchicine The risk or severity of adverse effects can be increased when Colchicine is combined with Tretinoin.
Dacarbazine Dacarbazine The risk or severity of adverse effects can be increased when Tretinoin is combined with Dacarbazine.
Bacillus Calmette-Guerin (BCG) Vaccine Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Tretinoin.
Ketoconazole Ketoconazole The metabolism of Tretinoin can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Thiotepa.
Vincristine Injection Vincristine Injection The metabolism of Tretinoin can be decreased when combined with Vincristine.
Captopril Captopril The risk or severity of adverse effects can be increased when Tretinoin is combined with Captopril.
Dipyridamole Dipyridamole The risk or severity of adverse effects can be increased when Tretinoin is combined with Dipyridamole.
Isoxsuprine Isoxsuprine The risk or severity of adverse effects can be increased when Tretinoin is combined with Isoxsuprine.
Vinblastine Vinblastine The risk or severity of adverse effects can be increased when Vinblastine is combined with Tretinoin.
Ethacrynic Acid Ethacrynic Acid The risk or severity of adverse effects can be increased when Tretinoin is combined with Etacrynic acid.
Metoprolol Metoprolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Metoprolol.
Hydroxyzine Hydroxyzine The metabolism of Tretinoin can be decreased when combined with Hydroxyzine.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Tretinoin.
Chlorambucil Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Tretinoin.
Alprazolam Alprazolam The metabolism of Tretinoin can be decreased when combined with Alprazolam.
Triazolam Triazolam The metabolism of Triazolam can be decreased when combined with Tretinoin.
Trimethoprim Trimethoprim The metabolism of Tretinoin can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Tretinoin can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Nifedipine can be decreased when combined with Tretinoin.
Timolol Timolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Timolol.
Verapamil Verapamil The metabolism of Tretinoin can be decreased when combined with Verapamil.
Atenolol Atenolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Atenolol.
Pindolol Pindolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Pindolol.
Cisplatin Injection Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Tretinoin.
Piroxicam Piroxicam The metabolism of Tretinoin can be decreased when combined with Piroxicam.
Bumetanide Bumetanide The risk or severity of adverse effects can be increased when Tretinoin is combined with Bumetanide.
Streptozocin Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Tretinoin.
Etoposide Etoposide The metabolism of Etoposide can be decreased when combined with Tretinoin.
Glyburide Glyburide The metabolism of Tretinoin can be decreased when combined with Glyburide.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Tretinoin.
Indapamide Indapamide The risk or severity of adverse effects can be increased when Tretinoin is combined with Indapamide.
Pentoxifylline Pentoxifylline The risk or severity of hypotension can be increased when Pentoxifylline is combined with Tretinoin.
Pentamidine Injection Pentamidine Injection The metabolism of Tretinoin can be decreased when combined with Pentamidine.
Labetalol Labetalol The risk or severity of adverse effects can be increased when Tretinoin is combined with Labetalol.
Gemfibrozil Gemfibrozil The metabolism of Tretinoin can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz Tretinoin may increase the hypotensive activities of Guanabenz.
Ketoprofen Ketoprofen The metabolism of Tretinoin can be decreased when combined with Ketoprofen.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Tretinoin.
Enalapril Enalapril The risk or severity of adverse effects can be increased when Tretinoin is combined with Enalapril.
Flurbiprofen Flurbiprofen The metabolism of Tretinoin can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Tretinoin.
Buspirone Buspirone The metabolism of Tretinoin can be decreased when combined with Buspirone.
Lovastatin Lovastatin The metabolism of Tretinoin can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Tretinoin can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Tretinoin can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The metabolism of Tretinoin can be decreased when combined with Fluoxetine.
Nimodipine Nimodipine The risk or severity of adverse effects can be increased when Tretinoin is combined with Nimodipine.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Tretinoin.
Clozapine Clozapine The metabolism of Tretinoin can be decreased when combined with Clozapine.
Idarubicin Idarubicin The risk or severity of adverse effects can be increased when Tretinoin is combined with Idarubicin.
Fludarabine Injection Fludarabine Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Fludarabine.
Pentostatin Injection Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Tretinoin.
Clarithromycin Clarithromycin The metabolism of Tretinoin can be decreased when combined with Clarithromycin.
Benazepril Benazepril The risk or severity of adverse effects can be increased when Tretinoin is combined with Benazepril.
Etodolac Etodolac The metabolism of Tretinoin can be decreased when combined with Etodolac.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Tretinoin.
Fosinopril Fosinopril The risk or severity of adverse effects can be increased when Tretinoin is combined with Fosinopril.
Nabumetone Nabumetone The metabolism of Tretinoin can be decreased when combined with Nabumetone.
Quinapril Quinapril The risk or severity of adverse effects can be increased when Tretinoin is combined with Quinapril.
Ramipril Ramipril The risk or severity of adverse effects can be increased when Tretinoin is combined with Ramipril.
Simvastatin Simvastatin The metabolism of Tretinoin can be decreased when combined with Simvastatin.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Tretinoin.
Amlodipine Amlodipine The risk or severity of adverse effects can be increased when Amlodipine is combined with Tretinoin.
Teniposide Injection Teniposide Injection The metabolism of Tretinoin can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Tretinoin can be decreased when combined with Itraconazole.
Lisinopril Lisinopril The risk or severity of adverse effects can be increased when Tretinoin is combined with Lisinopril.
Atovaquone Atovaquone The metabolism of Tretinoin can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Tretinoin can be increased when combined with Rifabutin.
Sotalol Sotalol The risk or severity of adverse effects can be increased when Sotalol is combined with Tretinoin.
Bisoprolol Bisoprolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Bisoprolol.
Zolpidem Zolpidem The metabolism of Tretinoin can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The risk or severity of adverse effects can be increased when Tretinoin is combined with Doxazosin.
Terazosin Terazosin The risk or severity of adverse effects can be increased when Tretinoin is combined with Terazosin.
Isradipine Isradipine The risk or severity of adverse effects can be increased when Tretinoin is combined with Isradipine.
Omeprazole Omeprazole The metabolism of Tretinoin can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Tretinoin can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Tretinoin can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The metabolism of Tretinoin can be decreased when combined with Venlafaxine.
Fluvoxamine Fluvoxamine The metabolism of Tretinoin can be decreased when combined with Fluvoxamine.
Losartan Losartan The metabolism of Tretinoin can be decreased when combined with Losartan.
Tramadol Tramadol The metabolism of Tretinoin can be decreased when combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The risk or severity of adverse effects can be increased when Vinorelbine is combined with Tretinoin.
Carboplatin Injection Carboplatin Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Carboplatin.
Moexipril Moexipril The risk or severity of adverse effects can be increased when Tretinoin is combined with Moexipril.
Lansoprazole Lansoprazole The metabolism of Tretinoin can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Tretinoin.
Pegaspargase Injection Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Tretinoin.
Nicardipine Nicardipine The metabolism of Tretinoin can be decreased when combined with Nicardipine.
Bupropion Bupropion The metabolism of Bupropion can be decreased when combined with Tretinoin.
Ticlopidine Ticlopidine The metabolism of Tretinoin can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Tretinoin can be decreased when combined with Saquinavir.
Nisoldipine Nisoldipine The metabolism of Tretinoin can be decreased when combined with Nisoldipine.
Amifostine Injection Amifostine Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Amifostine.
Glimepiride Glimepiride The metabolism of Tretinoin can be decreased when combined with Glimepiride.
Anastrozole Anastrozole The risk or severity of cardiotoxicity can be increased when Tretinoin is combined with Anastrozole.
Gemcitabine Injection Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Tretinoin.
Indinavir Indinavir The metabolism of Tretinoin can be decreased when combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Tretinoin can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Tretinoin.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Tretinoin.
Zafirlukast Zafirlukast The metabolism of Tretinoin can be decreased when combined with Zafirlukast.
Trandolapril Trandolapril The risk or severity of adverse effects can be increased when Tretinoin is combined with Trandolapril.
Zileuton Zileuton The metabolism of Tretinoin can be decreased when combined with Zileuton.
Valsartan Valsartan The metabolism of Tretinoin can be decreased when combined with Valsartan.
Pramipexole Pramipexole The risk or severity of adverse effects can be increased when Pramipexole is combined with Tretinoin.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Tretinoin.
Nelfinavir Nelfinavir The metabolism of Tretinoin can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Tretinoin can be decreased when combined with Azithromycin.
Loratadine Loratadine The metabolism of Tretinoin can be decreased when combined with Loratadine.
Carvedilol Carvedilol The risk or severity of adverse effects can be increased when Tretinoin is combined with Carvedilol.
Nilutamide Nilutamide The metabolism of Tretinoin can be decreased when combined with Nilutamide.
Flutamide Flutamide The metabolism of Tretinoin can be decreased when combined with Flutamide.
Selegiline Selegiline Selegiline may increase the orthostatic hypotensive activities of Tretinoin.
Bicalutamide Bicalutamide The metabolism of Tretinoin can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Tretinoin can be decreased when combined with Sertraline.
Letrozole Letrozole The metabolism of Tretinoin can be decreased when combined with Letrozole.
Raloxifene Raloxifene The metabolism of Tretinoin can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Tretinoin can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin The risk or severity of adverse effects can be increased when Tamsulosin is combined with Tretinoin.
Ropinirole Ropinirole The risk or severity of adverse effects can be increased when Ropinirole is combined with Tretinoin.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Tretinoin.
Quetiapine Quetiapine The metabolism of Quetiapine can be decreased when combined with Tretinoin.
Paroxetine Paroxetine The metabolism of Tretinoin can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Tretinoin can be decreased when combined with Tolcapone.
Capecitabine Capecitabine The metabolism of Capecitabine can be decreased when combined with Tretinoin.
Efavirenz Efavirenz The metabolism of Tretinoin can be increased when combined with Efavirenz.
Sildenafil Sildenafil The metabolism of Tretinoin can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Tretinoin can be decreased when combined with Pioglitazone.
Trastuzumab Injection Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Tretinoin.
Celecoxib Celecoxib The metabolism of Tretinoin can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Tretinoin can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Tretinoin.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Tretinoin is combined with Thalidomide.
Nateglinide Nateglinide The metabolism of Tretinoin can be decreased when combined with Nateglinide.
Rabeprazole Rabeprazole The metabolism of Tretinoin can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Tretinoin.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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