Tretinoin drug information | HelloPharmacist

Why is this medication prescribed?
How should this medicine be used?
Other uses for this medicine
What special precautions should I follow?
What special dietary instructions should I follow?
What should I do if I forget a dose?
What side effects can this medication cause?
What should I know about STORAGE and DISPOSAL of this medication?
What should I do in case of OVERDOSE?
What OTHER INFORMATION should I know?
Drug interactions

IMPORTANT WARNING

Tretinoin may cause severe side effects. Tretinoin should be given only under the supervision of a doctor who has experience in treating people who have leukemia (cancer of the white blood cells) and in a hospital where patients can be monitored for severe side effects and treated if these side effects occur.

Tretinoin may cause a serious or life-threatening group of symptoms called retinoic acid-APL(RA-APL) syndrome. Your doctor will monitor you carefully to see whether you are developing this syndrome. If you experience any of the following symptoms, call your doctor immediately: fever; weight gain; swelling of the arms, hands, feet, ankles, or lower legs; shortness of breath; labored breathing; wheezing; chest pain; or cough. At the first sign that you are developing RA-APL syndrome, your doctor will prescribe one or more medications to treat the syndrome.

Tretinoin may cause a rapid increase in the number of white blood cells in the body. This is associated with a higher risk of life-threatening side effects. If you have a very high number of white blood cells before you begin tretinoin treatment, or if you have an increase in the number of white blood cells during your treatment with tretinoin, expecially if you experience any of the symptoms of RA-APL syndrome, your doctor may prescribe one or more medications to treat or prevent the increase in white blood cells.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to tretinoin.

Talk to your doctor about the risk(s) of taking tretinoin.

For female patients:

Tretinoin must not be taken by patients who are pregnant or who may become pregnant. There is a high risk that tretinoin will cause the baby to be born with birth defects (physical problems that are present at birth).

If you can become pregnant, you will need to avoid pregnancy during your treatment with tretinoin. You must use two acceptable forms of birth control during your treatment and for 1 month after your treatment, even if you have infertility (difficulty becoming pregnant) or have experienced menopause ('change of life'; end of monthly menstrual periods). You must use these two forms of birth control at all times unless you can promise that you will not have any sexual contact with a male for 1 month after your treatment. Your doctor will tell you which forms of birth control are acceptable, and will give you full information about birth control.

If you plan to use oral contraceptives (birth control pills) while taking tretinoin, tell your doctor the name of the pill you will use. Microdosed progestin ('minipill') oral contraceptives (Ovrette, Micronor, Nor-D) may not be an effective form of birth control for people who are taking tretinoin.

You must have a negative pregnancy test within 1 week before you begin to take tretinoin. You will also need to be tested for pregnancy in a laboratory each month during your treatment. Tell your doctor immediately if you think you might be pregnant at any time during your treatment with tretinoin.

Why is this medication prescribed?

Tretinoin is used to treat acute promyelocytic leukemia (APL; a type of cancer in which there are too many immature blood cells in the blood and bone marrow) in people who have not been helped by other types of chemotherapy or whose condition has improved but then worsened following treatment with other types of chemotherapy. Tretinoin is used to produce remission (a decrease or disappearance of signs and symptoms of cancer) of APL, but other medications must be used after treatment with tretinoin to prevent the cancer from returning. Tretinoin is in a class of medications called retinoids. It works by slowing or stopping the growth of cancer cells by causing immature blood cells to develop into normal blood cells.

How should this medicine be used?

Tretinoin comes as a capsule to take by mouth. It is usually taken twice a day for up to 90 days. Take tretinoin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tretinoin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take tretinoin even if you feel well. Do not stop taking tretinoin without talking to your doctor.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking tretinoin,

tell your doctor and pharmacist if you are allergic to tretinoin, other retinoids such as acitretin (Soriatane), etretinate (Tegison), bexarotene, or isotretinoin (Accutane, Claravis, Sotret), any other medications, parabens (a preservative), or any of the other ingredients in tretinoin capsules. Ask your doctor or pharmacist for a list of the ingredients.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminocaproic acid (Amicar); certain calcium channel blockers such as diltiazem (Cardizem, Dilacor, Tiazac, others) and verapamil (Calan, Covera, Isoptin, Verelan); cimetidine (Tagamet); cyclosporine (Sandimmune, Gengraf, Neoral); erythromycin (E.E.S., Erythrocin, E-Mycin); hydroxyurea (Droxia); ketoconazole (Nizoral); pentobarbital; phenobarbital; rifampin (Rifadin, Rimactane);oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); tetracycline antibiotics such as demeclocycline (Declomycin), doxycycline (Monodox, Vibramycin, others), minocycline (Minocin), oxytetracycline (Terramycin), and tetracycline (Sumycin, Tetrex, others); tranexamic acid (Cyklokapron); and vitamin A. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with tretinoin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

tell your doctor if you have or have ever had increased amounts of cholesterol (a fat-like substance) and other fatty substances in the blood, or liver or heart disease.

tell your doctor if you are breast-feeding.

if you will be having surgery, including dental surgery, tell your doctor or dentist that you are taking tretinoin.

you should know that tretinoin may cause dizziness or severe headache.Do not drive a car or operate machinery until you know how this medication affects you.

What special dietary instructions should I follow?

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Tretinoin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- weakness
- extreme tiredness
- shivering
- pain
- earache
- feeling of fullness in the ears
- dry skin
- rash
- hair loss
- constipation
- diarrhea
- stomach pain
- heartburn
- loss of appetite
- weight loss
- bone pain
- dizziness
- numbness, burning, or tingling in the hands or feet
- nervousness
- depression
- difficulty falling asleep or staying asleep
- confusion
- agitation
- hallucinating (seeing things or hearing voices that do not exist)
- difficulty urinating
- flushing

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
- headache
- nausea
- vomiting
- blurred or double vision, or other vision problems
- unusual bruising or bleeding
- vomit that is bloody or looks like coffee grounds
- bright red or black and tarry stools
- irregular heartbeat
- hearing loss
- bleeding
- infections
Tretinoin may increase the levels of cholesterol and other fats in your blood and may stop your liver from working normally. Your doctor will monitor you carefully to see whether you are experiencing either of these side effects.
Tretinoin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

headache
flushing
red, cracked, and sore lips
stomach pain
dizziness
loss of coordination

What OTHER INFORMATION should I know?

Do not let anyone else take your medication. Ask your pharmacist if you have any questions about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug interactions

Drug	Interaction
Repaglinide	Repaglinide The metabolism of Repaglinide can be decreased when combined with Tretinoin.
Montelukast	Montelukast The metabolism of Tretinoin can be decreased when combined with Montelukast.
Leflunomide	Leflunomide The risk or severity of adverse effects can be increased when Tretinoin is combined with Leflunomide.
Delavirdine	Delavirdine The metabolism of Tretinoin can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Tretinoin can be increased when combined with Nevirapine.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Tretinoin.
Candesartan	Candesartan The metabolism of Tretinoin can be decreased when combined with Candesartan.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Tretinoin.
Clopidogrel	Clopidogrel The metabolism of Tretinoin can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The metabolism of Tretinoin can be decreased when combined with Erythromycin.
Fenofibrate	Fenofibrate The metabolism of Tretinoin can be decreased when combined with Fenofibrate.
Guanfacine	Guanfacine The risk or severity of adverse effects can be increased when Tretinoin is combined with Guanfacine.
Mycophenolate	Mycophenolate The risk or severity of adverse effects can be increased when Tretinoin is combined with Mycophenolic acid.
Paregoric	Paregoric The metabolism of Tretinoin can be decreased when combined with Morphine.
Penbutolol	Penbutolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Acebutolol.
Prednisone	Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Tretinoin.
Reserpine	Reserpine The metabolism of Tretinoin can be increased when combined with Reserpine.
Tacrolimus	Tacrolimus Tacrolimus may increase the immunosuppressive activities of Tretinoin.
Tizanidine	Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Tretinoin.
Triamcinolone	Triamcinolone The risk or severity of adverse effects can be increased when Triamcinolone is combined with Tretinoin.
Doxycycline Injection	Doxycycline Injection The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Doxycycline.
Fluconazole Injection	Fluconazole Injection The metabolism of Tretinoin can be decreased when combined with Fluconazole.
Hydromorphone Injection	Hydromorphone Injection The metabolism of Tretinoin can be decreased when combined with Hydromorphone.
Interferon Beta-1b Injection	Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Tretinoin.
Interferon Gamma-1b Injection	Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Tretinoin.
Meperidine Injection	Meperidine Injection The metabolism of Tretinoin can be decreased when combined with Meperidine.
Methylprednisolone Injection	Methylprednisolone Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Methylprednisolone.
Metronidazole Injection	Metronidazole Injection The metabolism of Tretinoin can be decreased when combined with Metronidazole.
Morphine Injection	Morphine Injection The metabolism of Tretinoin can be decreased when combined with Morphine.
Zidovudine Injection	Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Tretinoin.
Altretamine	Altretamine Amphetamine may increase the orthostatic hypotensive activities of Tretinoin.
Cyclosporine	Cyclosporine Tretinoin may increase the immunosuppressive activities of Cyclosporine.
Ondansetron	Ondansetron The metabolism of Ondansetron can be decreased when combined with Tretinoin.
Torsemide	Torsemide The metabolism of Tretinoin can be decreased when combined with Torasemide.
Olanzapine	Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Tretinoin.
Alosetron	Alosetron The metabolism of Alosetron can be decreased when combined with Tretinoin.
Eprosartan	Eprosartan The risk or severity of adverse effects can be increased when Tretinoin is combined with Eprosartan.
Hydroxychloroquine	Hydroxychloroquine The risk or severity of adverse effects can be increased when Tretinoin is combined with Hydroxychloroquine.
Meloxicam	Meloxicam The metabolism of Meloxicam can be decreased when combined with Tretinoin.
Orlistat	Orlistat Orlistat can cause a decrease in the absorption of Tretinoin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxcarbazepine	Oxcarbazepine The metabolism of Tretinoin can be increased when combined with Oxcarbazepine.
Telmisartan	Telmisartan The risk or severity of adverse effects can be increased when Tretinoin is combined with Telmisartan.
Temozolomide	Temozolomide The risk or severity of adverse effects can be increased when Tretinoin is combined with Temozolomide.
Zaleplon	Zaleplon The metabolism of Zaleplon can be decreased when combined with Tretinoin.
Anakinra	Anakinra The metabolism of Tretinoin can be increased when combined with Anakinra.
Linezolid	Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Tretinoin.
Trimipramine	Trimipramine The metabolism of Tretinoin can be decreased when combined with Trimipramine.
Etanercept Injection	Etanercept Injection The metabolism of Tretinoin can be increased when combined with Etanercept.
Modafinil	Modafinil The metabolism of Tretinoin can be increased when combined with Modafinil.
Perindopril	Perindopril The risk or severity of adverse effects can be increased when Tretinoin is combined with Perindopril.
Sirolimus	Sirolimus The metabolism of Sirolimus can be decreased when combined with Tretinoin.
Dutasteride	Dutasteride The metabolism of Dutasteride can be decreased when combined with Tretinoin.
Epinephrine Injection	Epinephrine Injection The metabolism of Tretinoin can be decreased when combined with Epinephrine.
Epirubicin	Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Tretinoin.
Eplerenone	Eplerenone The metabolism of Tretinoin can be decreased when combined with Eplerenone.
Olmesartan	Olmesartan The risk or severity of adverse effects can be increased when Tretinoin is combined with Olmesartan.
Zonisamide	Zonisamide The metabolism of Zonisamide can be decreased when combined with Tretinoin.
Adalimumab Injection	Adalimumab Injection The metabolism of Tretinoin can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Tretinoin.
Glatiramer Injection	Glatiramer Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Glatiramer.
Atazanavir	Atazanavir The metabolism of Atazanavir can be decreased when combined with Tretinoin.
Almotriptan	Almotriptan The metabolism of Almotriptan can be decreased when combined with Tretinoin.
Eletriptan	Eletriptan The metabolism of Tretinoin can be increased when combined with Eletriptan.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Tretinoin.
Vardenafil	Vardenafil The metabolism of Vardenafil can be decreased when combined with Tretinoin.
Aprepitant	Aprepitant The metabolism of Tretinoin can be decreased when combined with Aprepitant.
Memantine	Memantine The metabolism of Tretinoin can be decreased when combined with Memantine.
Tegaserod	Tegaserod The metabolism of Tretinoin can be decreased when combined with Tegaserod.
Tadalafil	Tadalafil The metabolism of Tadalafil can be decreased when combined with Tretinoin.
Progesterone	Progesterone The metabolism of Tretinoin can be decreased when combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The metabolism of Tretinoin can be decreased when combined with Apomorphine.
Darbepoetin Alfa Injection	Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Tretinoin.
Infliximab Injection	Infliximab Injection The metabolism of Tretinoin can be increased when combined with Infliximab.
Oxandrolone	Oxandrolone The metabolism of Tretinoin can be decreased when combined with Oxandrolone.
Rifaximin	Rifaximin The metabolism of Tretinoin can be increased when combined with Rifaximin.
Duloxetine	Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Tretinoin is combined with Duloxetine.
Norethindrone	Norethindrone The therapeutic efficacy of Norethisterone can be decreased when used in combination with Tretinoin.
Bosentan	Bosentan The metabolism of Tretinoin can be increased when combined with Bosentan.
Natalizumab Injection	Natalizumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Natalizumab.
Erlotinib	Erlotinib The metabolism of Tretinoin can be decreased when combined with Erlotinib.
Eszopiclone	Eszopiclone The metabolism of Tretinoin can be decreased when combined with Eszopiclone.
Voriconazole	Voriconazole The metabolism of Tretinoin can be decreased when combined with Voriconazole.
Dextroamphetamine	Dextroamphetamine Amphetamine may increase the orthostatic hypotensive activities of Tretinoin.
Peginterferon Alfa-2a Injection	Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Tretinoin.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Tretinoin.
Isocarboxazid	Isocarboxazid Isocarboxazid may increase the orthostatic hypotensive activities of Tretinoin.
Ramelteon	Ramelteon The metabolism of Ramelteon can be decreased when combined with Tretinoin.
Fentanyl	Fentanyl The metabolism of Fentanyl can be decreased when combined with Tretinoin.
Deferasirox	Deferasirox The metabolism of Tretinoin can be decreased when combined with Deferasirox.
Felbamate	Felbamate The metabolism of Tretinoin can be decreased when combined with Felbamate.
Abatacept Injection	Abatacept Injection The metabolism of Tretinoin can be increased when combined with Abatacept.
Rasagiline	Rasagiline Rasagiline may increase the orthostatic hypotensive activities of Tretinoin.
Imatinib	Imatinib The risk or severity of adverse effects can be increased when Imatinib is combined with Tretinoin.
Sitagliptin	Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Tretinoin.
Bevacizumab Injection	Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Tretinoin.
Gefitinib	Gefitinib The metabolism of Tretinoin can be decreased when combined with Gefitinib.
Paliperidone	Paliperidone The metabolism of Paliperidone can be decreased when combined with Tretinoin.
Bortezomib	Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Tretinoin.
Clofarabine Injection	Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Tretinoin.
Hepatitis B Vaccine	Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Tretinoin.
Influenza Vaccine, Inactivated or Recombinant	Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Tretinoin.
Influenza Vaccine, Live Intranasal	Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Tretinoin.
Live Shingles (Zoster) Vaccine (ZVL)	Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Tretinoin.
Oxaliplatin Injection	Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Tretinoin.
Rituximab Injection	Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Tretinoin.
Aliskiren	Aliskiren The risk or severity of adverse effects can be increased when Tretinoin is combined with Aliskiren.
Pemetrexed Injection	Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Tretinoin.
Nabilone	Nabilone The metabolism of Tretinoin can be decreased when combined with Nabilone.
Vorinostat	Vorinostat The risk or severity of adverse effects can be increased when Tretinoin is combined with Vorinostat.
Sorafenib	Sorafenib The metabolism of Tretinoin can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib The metabolism of Sunitinib can be decreased when combined with Tretinoin.
Dronabinol	Dronabinol The metabolism of Tretinoin can be decreased when combined with Dronabinol.
Lapatinib	Lapatinib The metabolism of Tretinoin can be decreased when combined with Lapatinib.
Verteporfin Injection	Verteporfin Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Verteporfin.
Dasatinib	Dasatinib The metabolism of Dasatinib can be decreased when combined with Tretinoin.
Mexiletine	Mexiletine The metabolism of Tretinoin can be decreased when combined with Mexiletine.
Armodafinil	Armodafinil The metabolism of Tretinoin can be increased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Azacitidine.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Tretinoin.
Nelarabine Injection	Nelarabine Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Nelarabine.
Lenalidomide	Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Tretinoin.
Nilotinib	Nilotinib The risk or severity of adverse effects can be increased when Tretinoin is combined with Nilotinib.
Bexarotene	Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Tretinoin.
Budesonide	Budesonide The risk or severity of adverse effects can be increased when Budesonide is combined with Tretinoin.
Chloramphenicol Injection	Chloramphenicol Injection The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Tretinoin.
Decitabine Injection	Decitabine Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Decitabine.
Etravirine	Etravirine The metabolism of Tretinoin can be decreased when combined with Etravirine.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Arsenic trioxide.
Mitoxantrone Injection	Mitoxantrone Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Mitoxantrone.
Aminocaproic Acid	Aminocaproic Acid The risk or severity of Thrombosis can be increased when Tretinoin is combined with Aminocaproic acid.
Nebivolol	Nebivolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Nebivolol.
Bendamustine Injection	Bendamustine Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Bendamustine.
Pilocarpine	Pilocarpine The metabolism of Tretinoin can be decreased when combined with Pilocarpine.
Flecainide	Flecainide The metabolism of Tretinoin can be decreased when combined with Flecainide.
Certolizumab Injection	Certolizumab Injection The metabolism of Tretinoin can be increased when combined with Certolizumab pegol.
Ixabepilone Injection	Ixabepilone Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Ixabepilone.
Irinotecan Injection	Irinotecan Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Irinotecan.
Estramustine	Estramustine The risk or severity of adverse effects can be increased when Tretinoin is combined with Estramustine.
Praziquantel	Praziquantel The metabolism of Praziquantel can be decreased when combined with Tretinoin.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia)	Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Tretinoin.
Midazolam	Midazolam The metabolism of Tretinoin can be decreased when combined with Midazolam.
Dexrazoxane Injection	Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Tretinoin.
Eltrombopag	Eltrombopag The metabolism of Tretinoin can be decreased when combined with Eltrombopag.
Ibritumomab Injection	Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Tretinoin.
Betaxolol	Betaxolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Betaxolol.
Iloperidone	Iloperidone The metabolism of Iloperidone can be decreased when combined with Tretinoin.
Prasugrel	Prasugrel The metabolism of Prasugrel can be decreased when combined with Tretinoin.
Lacosamide	Lacosamide The metabolism of Lacosamide can be decreased when combined with Tretinoin.
Everolimus	Everolimus The risk or severity of adverse effects can be increased when Tretinoin is combined with Everolimus.
Dronedarone	Dronedarone The metabolism of Tretinoin can be decreased when combined with Dronedarone.
Pralatrexate Injection	Pralatrexate Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Pralatrexate.
Saxagliptin	Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Tretinoin.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Tretinoin.
Tapentadol	Tapentadol The metabolism of Tapentadol can be decreased when combined with Tretinoin.
Topotecan	Topotecan The risk or severity of adverse effects can be increased when Tretinoin is combined with Topotecan.
Golimumab Injection	Golimumab Injection The metabolism of Tretinoin can be increased when combined with Golimumab.
Pazopanib	Pazopanib The metabolism of Pazopanib can be decreased when combined with Tretinoin.
Pitavastatin	Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Tretinoin.
Levonorgestrel	Levonorgestrel The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Tretinoin.
Denosumab Injection	Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Tretinoin.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Tretinoin can be increased when combined with Tocilizumab.
Fingolimod	Fingolimod Tretinoin may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection	Eribulin Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Eribulin.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Tretinoin.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Tretinoin can be decreased when combined with Acetaminophen.
Denileukin Diftitox Injection	Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Tretinoin.
Sipuleucel-T Injection	Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Tretinoin.
Belimumab Injection	Belimumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Belimumab.
Azilsartan	Azilsartan The risk or severity of adverse effects can be increased when Tretinoin is combined with Azilsartan medoxomil.
Busulfan Injection	Busulfan Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Busulfan.
Roflumilast	Roflumilast Roflumilast may increase the immunosuppressive activities of Tretinoin.
Rilpivirine	Rilpivirine The metabolism of Tretinoin can be decreased when combined with Rilpivirine.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Tretinoin can be decreased when combined with Cyclophosphamide.
Abiraterone	Abiraterone The metabolism of Tretinoin can be decreased when combined with Abiraterone.
Rivaroxaban	Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Tretinoin.
Ticagrelor	Ticagrelor The metabolism of Tretinoin can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Brentuximab vedotin.
Ruxolitinib	Ruxolitinib The risk or severity of adverse effects can be increased when Tretinoin is combined with Ruxolitinib.
Clobazam	Clobazam The metabolism of Tretinoin can be decreased when combined with Clobazam.
Vemurafenib	Vemurafenib The metabolism of Tretinoin can be decreased when combined with Vemurafenib.
Vismodegib	Vismodegib The metabolism of Tretinoin can be decreased when combined with Vismodegib.
Belatacept Injection	Belatacept Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Belatacept.
Ivacaftor	Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Tretinoin.
Basiliximab Injection	Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Tretinoin.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Tretinoin.
Crizotinib	Crizotinib The metabolism of Tretinoin can be decreased when combined with Crizotinib.
Melphalan Injection	Melphalan Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Melphalan.
Tranexamic Acid	Tranexamic Acid The risk or severity of Thrombosis can be increased when Tretinoin is combined with Tranexamic acid.
Ambrisentan	Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Tretinoin.
Eculizumab Injection	Eculizumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Eculizumab.
Pertuzumab Injection	Pertuzumab Injection The risk or severity of cardiotoxicity can be increased when Tretinoin is combined with Pertuzumab.
Carfilzomib Injection	Carfilzomib Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Carfilzomib.
Iloprost	Iloprost The risk or severity of adverse effects can be increased when Tretinoin is combined with Iloprost.
Enzalutamide	Enzalutamide The metabolism of Enzalutamide can be decreased when combined with Tretinoin.
Regorafenib	Regorafenib The metabolism of Tretinoin can be decreased when combined with Regorafenib.
Bosutinib	Bosutinib The risk or severity of adverse effects can be increased when Tretinoin is combined with Bosutinib.
Corticotropin, Repository Injection	Corticotropin, Repository Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Corticotropin.
Teriflunomide	Teriflunomide The risk or severity of adverse effects can be increased when Tretinoin is combined with Teriflunomide.
Cabozantinib (thyroid cancer)	Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Tretinoin.
Tofacitinib	Tofacitinib Tretinoin may increase the immunosuppressive activities of Tofacitinib.
Dimethyl Fumarate	Dimethyl Fumarate The risk or severity of adverse effects can be increased when Tretinoin is combined with Dimethyl fumarate.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Tretinoin.
Pomalidomide	Pomalidomide The risk or severity of adverse effects can be increased when Tretinoin is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Tretinoin.
Apixaban	Apixaban The metabolism of Apixaban can be decreased when combined with Tretinoin.
Canagliflozin	Canagliflozin The risk or severity of adverse effects can be increased when Tretinoin is combined with Canagliflozin.
Methazolamide	Methazolamide The risk or severity of adverse effects can be increased when Methazolamide is combined with Tretinoin.
Dabrafenib	Dabrafenib The metabolism of Tretinoin can be decreased when combined with Dabrafenib.
Ospemifene	Ospemifene The metabolism of Ospemifene can be decreased when combined with Tretinoin.
Trametinib	Trametinib The metabolism of Tretinoin can be decreased when combined with Trametinib.
Levomilnacipran	Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Tretinoin.
Tigecycline Injection	Tigecycline Injection The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Tigecycline.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Tretinoin.
Perampanel	Perampanel The metabolism of Perampanel can be decreased when combined with Tretinoin.
Ibrutinib	Ibrutinib The risk or severity of adverse effects can be increased when Tretinoin is combined with Ibrutinib.
Avanafil	Avanafil The risk or severity of hypotension can be increased when Avanafil is combined with Tretinoin.
Ketorolac Injection	Ketorolac Injection The metabolism of Tretinoin can be decreased when combined with Ketorolac.
Obinutuzumab Injection	Obinutuzumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Obinutuzumab.
Dapagliflozin	Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Tretinoin.
Apremilast	Apremilast The metabolism of Tretinoin can be increased when combined with Apremilast.
Ceritinib	Ceritinib The metabolism of Tretinoin can be decreased when combined with Ceritinib.
Siltuximab Injection	Siltuximab Injection The metabolism of Tretinoin can be increased when combined with Siltuximab.
Vedolizumab Injection	Vedolizumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Vedolizumab.
Belinostat Injection	Belinostat Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Belinostat.
Idelalisib	Idelalisib The risk or severity of adverse effects can be increased when Tretinoin is combined with Idelalisib.
Testosterone Injection	Testosterone Injection The metabolism of Tretinoin can be decreased when combined with Testosterone.
Oritavancin Injection	Oritavancin Injection The metabolism of Tretinoin can be decreased when combined with Oritavancin.
Empagliflozin	Empagliflozin The risk or severity of adverse effects can be increased when Tretinoin is combined with Empagliflozin.
Hydrocodone	Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Tretinoin.
Peginterferon Beta-1a Injection	Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Peginterferon beta-1a.
Olaparib	Olaparib The metabolism of Olaparib can be decreased when combined with Tretinoin.
Blinatumomab Injection	Blinatumomab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Blinatumomab.
Riociguat	Riociguat The metabolism of Riociguat can be decreased when combined with Tretinoin.
Pirfenidone	Pirfenidone The risk or severity of adverse effects can be increased when Tretinoin is combined with Pirfenidone.
Secukinumab Injection	Secukinumab Injection The metabolism of Tretinoin can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection Tretinoin may increase the hypotensive activities of Risperidone.
Palbociclib	Palbociclib The risk or severity of adverse effects can be increased when Tretinoin is combined with Palbociclib.
Lenvatinib	Lenvatinib The metabolism of Tretinoin can be decreased when combined with Lenvatinib.
Panobinostat	Panobinostat The risk or severity of adverse effects can be increased when Tretinoin is combined with Panobinostat.
Dinutuximab Injection	Dinutuximab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Dinutuximab.
Haloperidol Injection	Haloperidol Injection The serum concentration of Tretinoin can be increased when it is combined with Haloperidol.
Amiloride	Amiloride The risk or severity of adverse effects can be increased when Amiloride is combined with Tretinoin.
Macitentan	Macitentan Tretinoin may increase the hypotensive activities of Macitentan.
Prednisolone	Prednisolone The risk or severity of adverse effects can be increased when Tretinoin is combined with Prednisolone.
Daclatasvir	Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Tretinoin.
Ziprasidone Injection	Ziprasidone Injection The metabolism of Tretinoin can be decreased when combined with Ziprasidone.
Mepolizumab Injection	Mepolizumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Mepolizumab.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Tretinoin.
Rifapentine	Rifapentine The metabolism of Tretinoin can be increased when combined with Rifapentine.
Lesinurad	Lesinurad The metabolism of Lesinurad can be decreased when combined with Tretinoin.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection The risk or severity of adverse effects can be increased when Amphotericin B is combined with Tretinoin.
Dexamethasone Injection	Dexamethasone Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Dexamethasone.
Ixekizumab Injection	Ixekizumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Ixekizumab.
Brivaracetam Injection	Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Tretinoin.
Cobicistat	Cobicistat The metabolism of Tretinoin can be decreased when combined with Cobicistat.
Selexipag	Selexipag The metabolism of Selexipag can be decreased when combined with Tretinoin.
Diphenhydramine Injection	Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Tretinoin.
Furosemide Injection	Furosemide Injection The risk or severity of adverse effects can be increased when Furosemide is combined with Tretinoin.
Rucaparib	Rucaparib The metabolism of Tretinoin can be decreased when combined with Rucaparib.
Brodalumab Injection	Brodalumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Brodalumab.
Brigatinib	Brigatinib The metabolism of Brigatinib can be decreased when combined with Tretinoin.
Doxepin (Insomnia)	Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Tretinoin.
Deutetrabenazine	Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Tretinoin.
Valbenazine	Valbenazine The metabolism of Valbenazine can be decreased when combined with Tretinoin.
Deflazacort	Deflazacort The risk or severity of adverse effects can be increased when Tretinoin is combined with Deflazacort.
Safinamide	Safinamide Safinamide may increase the orthostatic hypotensive activities of Tretinoin.
Ocrelizumab Injection	Ocrelizumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Ocrelizumab.
Sarilumab Injection	Sarilumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Sarilumab.
Midostaurin	Midostaurin The metabolism of Tretinoin can be increased when combined with Midostaurin.
Guselkumab Injection	Guselkumab Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Guselkumab.
Enasidenib	Enasidenib The metabolism of Tretinoin can be decreased when combined with Enasidenib.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Tretinoin.
Delafloxacin	Delafloxacin The metabolism of Tretinoin can be increased when combined with Delafloxacin.
Acalabrutinib	Acalabrutinib The metabolism of Tretinoin can be decreased when combined with Acalabrutinib.
Gemtuzumab Ozogamicin Injection	Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Tretinoin.
Letermovir	Letermovir The metabolism of Tretinoin can be decreased when combined with Letermovir.
Buprenorphine Injection	Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Tretinoin.
Apalutamide	Apalutamide The metabolism of Tretinoin can be decreased when combined with Apalutamide.
Penicillamine	Penicillamine The risk or severity of adverse effects can be increased when Tretinoin is combined with Penicillamine.
Fostamatinib	Fostamatinib The risk or severity of hypotension can be increased when Fostamatinib is combined with Tretinoin.
Avatrombopag	Avatrombopag The metabolism of Tretinoin can be increased when combined with Avatrombopag.
Baricitinib	Baricitinib The risk or severity of adverse effects can be increased when Tretinoin is combined with Baricitinib.
Lofexidine	Lofexidine The risk or severity of adverse effects can be increased when Tretinoin is combined with Lofexidine.
Elagolix	Elagolix The metabolism of Elagolix can be decreased when combined with Tretinoin.
Eravacycline Injection	Eravacycline Injection The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Eravacycline.
Doravirine	Doravirine The metabolism of Doravirine can be decreased when combined with Tretinoin.
Cannabidiol	Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Tretinoin.
Dacomitinib	Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Tretinoin.
Omadacycline	Omadacycline The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Omadacycline.
Sarecycline	Sarecycline The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Sarecycline.
Stiripentol	Stiripentol The metabolism of Tretinoin can be decreased when combined with Stiripentol.
Glasdegib	Glasdegib The metabolism of Glasdegib can be decreased when combined with Tretinoin.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Tretinoin.
Methoxy Polyethylene Glycol-Epoetin Beta Injection	Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Tretinoin.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Tretinoin.
Rifamycin	Rifamycin The metabolism of Tretinoin can be decreased when combined with Rifamycin.
Ravulizumab-cwvz Injection	Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Ravulizumab.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Tretinoin can be increased when combined with Emapalumab.
Siponimod	Siponimod The metabolism of Siponimod can be decreased when combined with Tretinoin.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Tretinoin.
Risankizumab-rzaa Injection	Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Risankizumab.
Alpelisib	Alpelisib The serum concentration of Tretinoin can be decreased when it is combined with Alpelisib.
Cladribine	Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Tretinoin.
Triclabendazole	Triclabendazole The metabolism of Tretinoin can be decreased when combined with Triclabendazole.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Tretinoin.
Pitolisant	Pitolisant The serum concentration of Tretinoin can be decreased when it is combined with Pitolisant.
Phenytoin Injection	Phenytoin Injection The metabolism of Tretinoin can be decreased when combined with Phenytoin.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Tretinoin can be decreased when combined with Fosphenytoin.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Tretinoin.
Voxelotor	Voxelotor The metabolism of Voxelotor can be decreased when combined with Tretinoin.
Avapritinib	Avapritinib The metabolism of Avapritinib can be decreased when combined with Tretinoin.
Cenobamate	Cenobamate The serum concentration of Tretinoin can be decreased when it is combined with Cenobamate.
Ozanimod	Ozanimod The risk or severity of adverse effects can be increased when Tretinoin is combined with Ozanimod.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Tretinoin.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Tretinoin.
Selpercatinib	Selpercatinib The serum concentration of Tretinoin can be increased when it is combined with Selpercatinib.
Lemborexant	Lemborexant The serum concentration of Tretinoin can be decreased when it is combined with Lemborexant.
Pralsetinib	Pralsetinib The metabolism of Tretinoin can be decreased when combined with Pralsetinib.
Opicapone	Opicapone The metabolism of Tretinoin can be decreased when combined with Opicapone.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Tretinoin can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Drospirenone can be decreased when used in combination with Tretinoin.
Theophylline	Theophylline The metabolism of Tretinoin can be decreased when combined with Theophylline.
Indomethacin	Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Tretinoin.
Mefenamic Acid	Mefenamic Acid The metabolism of Tretinoin can be decreased when combined with Mefenamic acid.
Naproxen	Naproxen The metabolism of Naproxen can be decreased when combined with Tretinoin.
Trazodone	Trazodone The metabolism of Tretinoin can be decreased when combined with Trazodone.
Hydroxyurea	Hydroxyurea The risk or severity of adverse effects can be increased when Tretinoin is combined with Hydroxyurea.
Floxuridine	Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Tretinoin.
Phenobarbital	Phenobarbital The metabolism of Tretinoin can be decreased when combined with Phenobarbital.
Methotrexate Injection	Methotrexate Injection The risk or severity of adverse effects can be increased when Methotrexate is combined with Tretinoin.
Primidone	Primidone Tretinoin may increase the hypotensive activities of Primidone.
Chlorpromazine	Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Tretinoin.
Diazepam	Diazepam The metabolism of Diazepam can be decreased when combined with Tretinoin.
Flurazepam	Flurazepam The metabolism of Tretinoin can be decreased when combined with Flurazepam.
Phenoxybenzamine	Phenoxybenzamine The risk or severity of adverse effects can be increased when Tretinoin is combined with Phenoxybenzamine.
Carmustine	Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Tretinoin.
Bromocriptine	Bromocriptine The risk or severity of adverse effects can be increased when Tretinoin is combined with Bromocriptine.
Tranylcypromine	Tranylcypromine The metabolism of Tretinoin can be decreased when combined with Tranylcypromine.
Phenelzine	Phenelzine Phenelzine may increase the orthostatic hypotensive activities of Tretinoin.
Procarbazine	Procarbazine The risk or severity of adverse effects can be increased when Tretinoin is combined with Procarbazine.
Tetracycline	Tetracycline The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Tetracycline.
Thioguanine	Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Tretinoin.
Minocycline	Minocycline The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Minocycline.
Demeclocycline	Demeclocycline The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Demeclocycline.
Thioridazine	Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Tretinoin.
Bleomycin	Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Tretinoin.
Dapsone	Dapsone The metabolism of Tretinoin can be decreased when combined with Dapsone.
Sulfadiazine	Sulfadiazine The metabolism of Tretinoin can be decreased when combined with Sulfadiazine.
Oxycodone	Oxycodone The metabolism of Tretinoin can be decreased when combined with Oxycodone.
Methadone	Methadone The metabolism of Tretinoin can be decreased when combined with Methadone.
Oxybutynin	Oxybutynin The metabolism of Tretinoin can be decreased when combined with Oxybutynin.
Ibuprofen	Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Tretinoin.
Orphenadrine	Orphenadrine The metabolism of Tretinoin can be decreased when combined with Orphenadrine.
Azathioprine	Azathioprine The risk or severity of adverse effects can be increased when Tretinoin is combined with Azathioprine.
Sulfasalazine	Sulfasalazine The risk or severity of adverse effects can be increased when Tretinoin is combined with Sulfasalazine.
Hydrocortisone	Hydrocortisone The metabolism of Tretinoin can be increased when combined with Hydrocortisone.
Lomustine	Lomustine The risk or severity of adverse effects can be increased when Tretinoin is combined with Lomustine.
Doxorubicin	Doxorubicin The risk or severity of adverse effects can be increased when Tretinoin is combined with Doxorubicin.
Cytarabine	Cytarabine The risk or severity of adverse effects can be increased when Tretinoin is combined with Cytarabine.
Mechlorethamine	Mechlorethamine The risk or severity of adverse effects can be increased when Tretinoin is combined with Mechlorethamine.
Dactinomycin	Dactinomycin The risk or severity of adverse effects can be increased when Tretinoin is combined with Dactinomycin.
Carbamazepine	Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Tretinoin.
Methyldopa	Methyldopa The risk or severity of adverse effects can be increased when Tretinoin is combined with Methyldopa.
Clonidine	Clonidine The metabolism of Clonidine can be decreased when combined with Tretinoin.
Prazosin	Prazosin The risk or severity of adverse effects can be increased when Tretinoin is combined with Prazosin.
Hydralazine	Hydralazine The risk or severity of adverse effects can be increased when Tretinoin is combined with Hydralazine.
Cimetidine	Cimetidine The metabolism of Tretinoin can be decreased when combined with Cimetidine.
Warfarin	Warfarin The metabolism of Tretinoin can be decreased when combined with Warfarin.
Loperamide	Loperamide The metabolism of Loperamide can be decreased when combined with Tretinoin.
Promethazine	Promethazine The metabolism of Promethazine can be decreased when combined with Tretinoin.
Daunorubicin	Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Tretinoin.
Griseofulvin	Griseofulvin The metabolism of Tretinoin can be increased when combined with Griseofulvin.
Digoxin	Digoxin Digoxin may decrease the cardiotoxic activities of Tretinoin.
Chloroquine	Chloroquine The metabolism of Tretinoin can be decreased when combined with Chloroquine.
Quinine	Quinine The metabolism of Tretinoin can be decreased when combined with Quinine.
Triamterene	Triamterene The risk or severity of adverse effects can be increased when Triamterene is combined with Tretinoin.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Tretinoin can be decreased when combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide The risk or severity of adverse effects can be increased when Tretinoin is combined with Chlorothiazide.
Chlorthalidone	Chlorthalidone The risk or severity of adverse effects can be increased when Tretinoin is combined with Chlorthalidone.
Metolazone	Metolazone The risk or severity of adverse effects can be increased when Tretinoin is combined with Metolazone.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Tretinoin.
Secobarbital	Secobarbital The metabolism of Tretinoin can be increased when combined with Secobarbital.
Desipramine	Desipramine The metabolism of Desipramine can be decreased when combined with Tretinoin.
Amitriptyline	Amitriptyline The metabolism of Tretinoin can be decreased when combined with Amitriptyline.
Imipramine	Imipramine The metabolism of Tretinoin can be decreased when combined with Imipramine.
Probenecid	Probenecid The metabolism of Tretinoin can be increased when combined with Probenecid.
Quinidine	Quinidine The metabolism of Quinidine can be decreased when combined with Tretinoin.
Isoniazid	Isoniazid The metabolism of Tretinoin can be decreased when combined with Isoniazid.
Rifampin	Rifampin The metabolism of Tretinoin can be increased when combined with Rifampicin.
Valproic Acid	Valproic Acid Valproic acid may increase the Pseudotumor Cerebri activities of Tretinoin.
Tamoxifen	Tamoxifen The metabolism of Tretinoin can be decreased when combined with Tamoxifen.
Mitomycin	Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Tretinoin.
Butabarbital	Butabarbital Butabarbital may increase the hypotensive activities of Tretinoin.
Levothyroxine	Levothyroxine The metabolism of Tretinoin can be decreased when combined with Levothyroxine.
Methimazole	Methimazole The risk or severity of adverse effects can be increased when Tretinoin is combined with Methimazole.
Propylthiouracil	Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Tretinoin.
Chlorpropamide	Chlorpropamide The metabolism of Tretinoin can be decreased when combined with Chlorpropamide.
Tolbutamide	Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Tretinoin.
Tolazamide	Tolazamide The metabolism of Tolazamide can be decreased when combined with Tretinoin.
Dextromethorphan	Dextromethorphan The metabolism of Tretinoin can be decreased when combined with Dextromethorphan.
Chlorpheniramine	Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Tretinoin.
Brompheniramine	Brompheniramine The metabolism of Brompheniramine can be decreased when combined with Tretinoin.
Methyclothiazide	Methyclothiazide The risk or severity of adverse effects can be increased when Methyclothiazide is combined with Tretinoin.
Hydrochlorothiazide	Hydrochlorothiazide The risk or severity of adverse effects can be increased when Tretinoin is combined with Hydrochlorothiazide.
Chlorzoxazone	Chlorzoxazone The metabolism of Tretinoin can be decreased when combined with Chlorzoxazone.
Disulfiram	Disulfiram The metabolism of Disulfiram can be decreased when combined with Tretinoin.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The metabolism of Tretinoin can be decreased when combined with Propranolol.
Minoxidil	Minoxidil The risk or severity of adverse effects can be increased when Tretinoin is combined with Minoxidil.
Spironolactone	Spironolactone The metabolism of Tretinoin can be decreased when combined with Spironolactone.
Amphotericin B Injection	Amphotericin B Injection The risk or severity of adverse effects can be increased when Amphotericin B is combined with Tretinoin.
Mercaptopurine	Mercaptopurine The risk or severity of adverse effects can be increased when Tretinoin is combined with Mercaptopurine.
Nadolol	Nadolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Nadolol.
Papaverine	Papaverine The risk or severity of adverse effects can be increased when Tretinoin is combined with Papaverine.
Fluorouracil Injection	Fluorouracil Injection The metabolism of Tretinoin can be decreased when combined with Fluorouracil.
Colchicine	Colchicine The risk or severity of adverse effects can be increased when Colchicine is combined with Tretinoin.
Dacarbazine	Dacarbazine The risk or severity of adverse effects can be increased when Tretinoin is combined with Dacarbazine.
Bacillus Calmette-Guerin (BCG) Vaccine	Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Tretinoin.
Ketoconazole	Ketoconazole The metabolism of Tretinoin can be decreased when combined with Ketoconazole.
Thiotepa Injection	Thiotepa Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Thiotepa.
Vincristine Injection	Vincristine Injection The metabolism of Tretinoin can be decreased when combined with Vincristine.
Captopril	Captopril The risk or severity of adverse effects can be increased when Tretinoin is combined with Captopril.
Dipyridamole	Dipyridamole The risk or severity of adverse effects can be increased when Tretinoin is combined with Dipyridamole.
Isoxsuprine	Isoxsuprine The risk or severity of adverse effects can be increased when Tretinoin is combined with Isoxsuprine.
Vinblastine	Vinblastine The risk or severity of adverse effects can be increased when Vinblastine is combined with Tretinoin.
Ethacrynic Acid	Ethacrynic Acid The risk or severity of adverse effects can be increased when Tretinoin is combined with Etacrynic acid.
Metoprolol	Metoprolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Metoprolol.
Hydroxyzine	Hydroxyzine The metabolism of Tretinoin can be decreased when combined with Hydroxyzine.
Aspirin	Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Tretinoin.
Chlorambucil	Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Tretinoin.
Alprazolam	Alprazolam The metabolism of Tretinoin can be decreased when combined with Alprazolam.
Triazolam	Triazolam The metabolism of Triazolam can be decreased when combined with Tretinoin.
Trimethoprim	Trimethoprim The metabolism of Tretinoin can be decreased when combined with Trimethoprim.
Diltiazem	Diltiazem The metabolism of Tretinoin can be decreased when combined with Diltiazem.
Nifedipine	Nifedipine The metabolism of Nifedipine can be decreased when combined with Tretinoin.
Timolol	Timolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Timolol.
Verapamil	Verapamil The metabolism of Tretinoin can be decreased when combined with Verapamil.
Atenolol	Atenolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Atenolol.
Pindolol	Pindolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Pindolol.
Cisplatin Injection	Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Tretinoin.
Piroxicam	Piroxicam The metabolism of Tretinoin can be decreased when combined with Piroxicam.
Bumetanide	Bumetanide The risk or severity of adverse effects can be increased when Tretinoin is combined with Bumetanide.
Streptozocin	Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Tretinoin.
Etoposide	Etoposide The metabolism of Etoposide can be decreased when combined with Tretinoin.
Glyburide	Glyburide The metabolism of Tretinoin can be decreased when combined with Glyburide.
Glipizide	Glipizide The metabolism of Glipizide can be decreased when combined with Tretinoin.
Indapamide	Indapamide The risk or severity of adverse effects can be increased when Tretinoin is combined with Indapamide.
Pentoxifylline	Pentoxifylline The risk or severity of hypotension can be increased when Pentoxifylline is combined with Tretinoin.
Pentamidine Injection	Pentamidine Injection The metabolism of Tretinoin can be decreased when combined with Pentamidine.
Labetalol	Labetalol The risk or severity of adverse effects can be increased when Tretinoin is combined with Labetalol.
Gemfibrozil	Gemfibrozil The metabolism of Tretinoin can be decreased when combined with Gemfibrozil.
Guanabenz	Guanabenz Tretinoin may increase the hypotensive activities of Guanabenz.
Ketoprofen	Ketoprofen The metabolism of Tretinoin can be decreased when combined with Ketoprofen.
Pimozide	Pimozide The metabolism of Pimozide can be decreased when combined with Tretinoin.
Enalapril	Enalapril The risk or severity of adverse effects can be increased when Tretinoin is combined with Enalapril.
Flurbiprofen	Flurbiprofen The metabolism of Tretinoin can be decreased when combined with Flurbiprofen.
Amiodarone	Amiodarone The metabolism of Amiodarone can be decreased when combined with Tretinoin.
Buspirone	Buspirone The metabolism of Tretinoin can be decreased when combined with Buspirone.
Lovastatin	Lovastatin The metabolism of Tretinoin can be decreased when combined with Lovastatin.
Ciprofloxacin	Ciprofloxacin The metabolism of Tretinoin can be decreased when combined with Ciprofloxacin.
Diclofenac	Diclofenac The metabolism of Tretinoin can be decreased when combined with Diclofenac.
Fluoxetine	Fluoxetine The metabolism of Tretinoin can be decreased when combined with Fluoxetine.
Nimodipine	Nimodipine The risk or severity of adverse effects can be increased when Tretinoin is combined with Nimodipine.
Interferon Alfa-2b Injection	Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Tretinoin.
Clozapine	Clozapine The metabolism of Tretinoin can be decreased when combined with Clozapine.
Idarubicin	Idarubicin The risk or severity of adverse effects can be increased when Tretinoin is combined with Idarubicin.
Fludarabine Injection	Fludarabine Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Fludarabine.
Pentostatin Injection	Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Tretinoin.
Clarithromycin	Clarithromycin The metabolism of Tretinoin can be decreased when combined with Clarithromycin.
Benazepril	Benazepril The risk or severity of adverse effects can be increased when Tretinoin is combined with Benazepril.
Etodolac	Etodolac The metabolism of Tretinoin can be decreased when combined with Etodolac.
Felodipine	Felodipine The metabolism of Felodipine can be decreased when combined with Tretinoin.
Fosinopril	Fosinopril The risk or severity of adverse effects can be increased when Tretinoin is combined with Fosinopril.
Nabumetone	Nabumetone The metabolism of Tretinoin can be decreased when combined with Nabumetone.
Quinapril	Quinapril The risk or severity of adverse effects can be increased when Tretinoin is combined with Quinapril.
Ramipril	Ramipril The risk or severity of adverse effects can be increased when Tretinoin is combined with Ramipril.
Simvastatin	Simvastatin The metabolism of Tretinoin can be decreased when combined with Simvastatin.
Epoetin Alfa, Injection	Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Tretinoin.
Amlodipine	Amlodipine The risk or severity of adverse effects can be increased when Amlodipine is combined with Tretinoin.
Teniposide Injection	Teniposide Injection The metabolism of Tretinoin can be decreased when combined with Teniposide.
Itraconazole	Itraconazole The metabolism of Tretinoin can be decreased when combined with Itraconazole.
Lisinopril	Lisinopril The risk or severity of adverse effects can be increased when Tretinoin is combined with Lisinopril.
Atovaquone	Atovaquone The metabolism of Tretinoin can be decreased when combined with Atovaquone.
Rifabutin	Rifabutin The metabolism of Tretinoin can be increased when combined with Rifabutin.
Sotalol	Sotalol The risk or severity of adverse effects can be increased when Sotalol is combined with Tretinoin.
Bisoprolol	Bisoprolol The risk or severity of adverse effects can be increased when Tretinoin is combined with Bisoprolol.
Zolpidem	Zolpidem The metabolism of Tretinoin can be decreased when combined with Zolpidem.
Doxazosin	Doxazosin The risk or severity of adverse effects can be increased when Tretinoin is combined with Doxazosin.
Terazosin	Terazosin The risk or severity of adverse effects can be increased when Tretinoin is combined with Terazosin.
Isradipine	Isradipine The risk or severity of adverse effects can be increased when Tretinoin is combined with Isradipine.
Omeprazole	Omeprazole The metabolism of Tretinoin can be decreased when combined with Omeprazole.
Cisapride	Cisapride The metabolism of Tretinoin can be decreased when combined with Cisapride.
Fluvastatin	Fluvastatin The metabolism of Tretinoin can be decreased when combined with Fluvastatin.
Venlafaxine	Venlafaxine The metabolism of Tretinoin can be decreased when combined with Venlafaxine.
Fluvoxamine	Fluvoxamine The metabolism of Tretinoin can be decreased when combined with Fluvoxamine.
Losartan	Losartan The metabolism of Tretinoin can be decreased when combined with Losartan.
Tramadol	Tramadol The metabolism of Tretinoin can be decreased when combined with Tramadol.
Vinorelbine Injection	Vinorelbine Injection The risk or severity of adverse effects can be increased when Vinorelbine is combined with Tretinoin.
Carboplatin Injection	Carboplatin Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Carboplatin.
Moexipril	Moexipril The risk or severity of adverse effects can be increased when Tretinoin is combined with Moexipril.
Lansoprazole	Lansoprazole The metabolism of Tretinoin can be decreased when combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Tretinoin.
Pegaspargase Injection	Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Tretinoin.
Nicardipine	Nicardipine The metabolism of Tretinoin can be decreased when combined with Nicardipine.
Bupropion	Bupropion The metabolism of Bupropion can be decreased when combined with Tretinoin.
Ticlopidine	Ticlopidine The metabolism of Tretinoin can be decreased when combined with Ticlopidine.
Saquinavir	Saquinavir The metabolism of Tretinoin can be decreased when combined with Saquinavir.
Nisoldipine	Nisoldipine The metabolism of Tretinoin can be decreased when combined with Nisoldipine.
Amifostine Injection	Amifostine Injection The risk or severity of adverse effects can be increased when Tretinoin is combined with Amifostine.
Glimepiride	Glimepiride The metabolism of Tretinoin can be decreased when combined with Glimepiride.
Anastrozole	Anastrozole The risk or severity of cardiotoxicity can be increased when Tretinoin is combined with Anastrozole.
Gemcitabine Injection	Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Tretinoin.
Indinavir	Indinavir The metabolism of Tretinoin can be decreased when combined with Indinavir.
Ritonavir	Ritonavir The serum concentration of Tretinoin can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Tretinoin.
Clomipramine	Clomipramine The metabolism of Clomipramine can be decreased when combined with Tretinoin.
Zafirlukast	Zafirlukast The metabolism of Tretinoin can be decreased when combined with Zafirlukast.
Trandolapril	Trandolapril The risk or severity of adverse effects can be increased when Tretinoin is combined with Trandolapril.
Zileuton	Zileuton The metabolism of Tretinoin can be decreased when combined with Zileuton.
Valsartan	Valsartan The metabolism of Tretinoin can be decreased when combined with Valsartan.
Pramipexole	Pramipexole The risk or severity of adverse effects can be increased when Pramipexole is combined with Tretinoin.
Donepezil	Donepezil The metabolism of Donepezil can be decreased when combined with Tretinoin.
Nelfinavir	Nelfinavir The metabolism of Tretinoin can be decreased when combined with Nelfinavir.
Azithromycin	Azithromycin The metabolism of Tretinoin can be decreased when combined with Azithromycin.
Loratadine	Loratadine The metabolism of Tretinoin can be decreased when combined with Loratadine.
Carvedilol	Carvedilol The risk or severity of adverse effects can be increased when Tretinoin is combined with Carvedilol.
Nilutamide	Nilutamide The metabolism of Tretinoin can be decreased when combined with Nilutamide.
Flutamide	Flutamide The metabolism of Tretinoin can be decreased when combined with Flutamide.
Selegiline	Selegiline Selegiline may increase the orthostatic hypotensive activities of Tretinoin.
Bicalutamide	Bicalutamide The metabolism of Tretinoin can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The metabolism of Tretinoin can be decreased when combined with Sertraline.
Letrozole	Letrozole The metabolism of Tretinoin can be decreased when combined with Letrozole.
Raloxifene	Raloxifene The metabolism of Tretinoin can be decreased when combined with Raloxifene.
Irbesartan	Irbesartan The metabolism of Tretinoin can be decreased when combined with Irbesartan.
Tamsulosin	Tamsulosin The risk or severity of adverse effects can be increased when Tamsulosin is combined with Tretinoin.
Ropinirole	Ropinirole The risk or severity of adverse effects can be increased when Ropinirole is combined with Tretinoin.
Finasteride	Finasteride The metabolism of Finasteride can be decreased when combined with Tretinoin.
Quetiapine	Quetiapine The metabolism of Quetiapine can be decreased when combined with Tretinoin.
Paroxetine	Paroxetine The metabolism of Tretinoin can be decreased when combined with Paroxetine.
Tolcapone	Tolcapone The metabolism of Tretinoin can be decreased when combined with Tolcapone.
Capecitabine	Capecitabine The metabolism of Capecitabine can be decreased when combined with Tretinoin.
Efavirenz	Efavirenz The metabolism of Tretinoin can be increased when combined with Efavirenz.
Sildenafil	Sildenafil The metabolism of Tretinoin can be decreased when combined with Sildenafil.
Pioglitazone	Pioglitazone The metabolism of Tretinoin can be decreased when combined with Pioglitazone.
Trastuzumab Injection	Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Tretinoin.
Celecoxib	Celecoxib The metabolism of Tretinoin can be decreased when combined with Celecoxib.
Rosiglitazone	Rosiglitazone The metabolism of Tretinoin can be decreased when combined with Rosiglitazone.
Tolterodine	Tolterodine The metabolism of Tolterodine can be decreased when combined with Tretinoin.
Thalidomide	Thalidomide The risk or severity of adverse effects can be increased when Tretinoin is combined with Thalidomide.
Nateglinide	Nateglinide The metabolism of Tretinoin can be decreased when combined with Nateglinide.
Rabeprazole	Rabeprazole The metabolism of Tretinoin can be decreased when combined with Rabeprazole.
Terbinafine	Terbinafine The metabolism of Terbinafine can be decreased when combined with Tretinoin.

Tretinoin

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