Medication interaction hub

What Supplements Interact with Tretinoin?

Tretinoin brand names: Vesanoid, Retin-A, Renova, Altreno. Every interaction below applies to the brands too.

52 Interactions 2 Major 37 Moderate 13 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Tretinoin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Tretinoin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

52 supplements and herbal ingredients have interactions with Tretinoin on file in the HelloPharmacist interaction database — 2 rated major, 37 moderate, and 13 minor. The most serious involve Activated Charcoal and Vitamin A.

Our assessment: with 2 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Tretinoin.

Major 2 Moderate 37 Minor 13 No known interaction 1,400

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Tretinoin: Top Interactions at a Glance

The Tretinoin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 52 interacting ingredients — plus 1,400 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Tretinoin Combinations Today

The Tretinoin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Probable Vitamin A + Tretinoini

Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.

Read the full interaction Major Likelihood Probable Activated Charcoal + Tretinoini

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Moderate Likelihood Possible African Wild Potato + Tretinoini

In vitro research shows that African wild potato extract might inhibit cytochrome P450 2C8 (CYP2C8).

Read the full interaction Moderate Likelihood Possible Angelica Archangelica + Tretinoini

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full interaction Minor Likelihood Possible Celery + Tretinoini

Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.

Read the full interaction Moderate Likelihood Probable Glucomannan + Tretinoini

Theoretically, glucomannan may decrease absorption of drugs taken orally.

Read the full interaction
The complete list

Every Supplement Checked Against Tretinoin

All 1,452 ingredients in our database, ranked by severity — 52 with a Tretinoin interaction on file and 1,400 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Tretinoin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin A with Tretinoin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.

Full Vitamin A + Tretinoin answer

Can you take Activated Charcoal with Tretinoin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Tretinoin answer

Can you take African Wild Potato with Tretinoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that African wild potato extract might inhibit cytochrome P450 2C8 (CYP2C8).

Full African Wild Potato + Tretinoin answer

Can you take Angelica Archangelica with Tretinoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Full Angelica Archangelica + Tretinoin answer

Can you take Celery with Tretinoin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.

Full Celery + Tretinoin answer

Can you take Fucus Vesiculosus with Tretinoin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP2C8 substrates might increase the risk for adverse effects.

Full Fucus Vesiculosus + Tretinoin answer

Can you take Hibiscus Sabdariffa with Tretinoin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa might reduce the metabolism of CYP2C8 substrates.

Full Hibiscus Sabdariffa + Tretinoin answer

Can you take Karaya Gum with Tretinoin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Tretinoin answer

Can you take Marshmallow with Tretinoin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Tretinoin answer

Can you take Xanthan Gum with Tretinoin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Tretinoin answer

Can you take Bergamot with Tretinoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.

Full Bergamot + Tretinoin answer

Can you take Chenopodium Oil with Tretinoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chenopodium oil with other photosensitizing drugs can increase the risk of adverse effects.

Full Chenopodium Oil + Tretinoin answer

Can you take Chlorophyll with Tretinoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.

Full Chlorophyll + Tretinoin answer

Can you take Chlorophyllin with Tretinoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.

Full Chlorophyllin + Tretinoin answer

Can you take Coffee Charcoal with Tretinoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Tretinoin answer

Can you take European Mandrake with Tretinoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Tretinoin answer

Can you take Glucomannan with Tretinoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Tretinoin answer

Can you take Masterwort with Tretinoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The use of masterwort in conjunction with photosensitizing drugs is contraindicated due to the potential for additive photosensitizing effec...

Full Masterwort + Tretinoin answer

Can you take Wild Carrot with Tretinoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Wild Carrot + Tretinoin answer

Can you take Alfalfa with Tretinoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.

Full Alfalfa + Tretinoin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Tretinoin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Tretinoin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Tretinoin sits in 5 interaction categories. Open any one to see what the group means:

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Tretinoin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Tretinoin through this category.

Cytochrome P450 2C8 (Cyp2C8) Substrates 11 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

11 of the supplement ingredients on this page reach Tretinoin through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Tretinoin through this category.

Retinoids 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Tretinoin through this category.

About Tretinoin

Tretinoin is a vitamin A-derived cream used to help reduce the appearance of fine facial wrinkles as part of a full skin care routine.

Generic name: Tretinoin  ·  Brand names: Vesanoid, Retin-A, Renova, Altreno.

See the full Tretinoin drug information

Related: does Tretinoin deplete any nutrients?

Tretinoin has 4 reported nutrient associations in the research literature — see the Tretinoin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Tretinoin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Tretinoin.

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Pharmacist Counseling Corner

Tretinoin & Supplements: Common Questions

What supplements interact with Tretinoin?
In our interaction database, 52 supplement and herbal ingredients have an interaction with Tretinoin on file — 2 rated major, 37 moderate, and 13 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Vitamin A, Bergamot.
Which Tretinoin supplement interactions are the most serious?
Focus on the major group: Activated Charcoal and Vitamin A. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Tretinoin?
That depends entirely on which supplement. The honest answer for Tretinoin is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Vesanoid have the same supplement interactions as Tretinoin?
Yes — Vesanoid, Retin-A, Renova, Altreno all contain Tretinoin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Tretinoin deplete any vitamins or nutrients?
It might — Tretinoin has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Tretinoin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Tretinoin and my other medications?
This page covers Tretinoin against supplements and herbal ingredients. Checking Tretinoin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Tretinoin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.