Drug & supplement interaction

Gamma-oryzanol + Tretinoin

Tretinoin brand names: Vesanoid, Retin-A, Renova, Altreno.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Gamma-oryzanol and Tretinoin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tretinoin states a food rule worth keeping to.

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Interaction report

Gamma-oryzanol and Tretinoin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tretinoin and Gamma-oryzanol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Gamma-oryzanol at all — not against Tretinoin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Gamma-oryzanol safety at a glance

Gamma-oryzanol overall Use caution Generally well tolerated in studies, but long-term safety is not well established.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tretinoin and Gamma-oryzanol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Tretinoin’s Own FDA Label Lists

This is not an interaction — none of it involves Gamma-oryzanol. These are the most notable effects listed in the ADVERSE REACTIONS section of Tretinoin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on
  • Confusion Worth acting on
  • Chest pain Worth acting on
  • Low mood Worth acting on
  • Kidney problems Worth acting on
  • Raised blood pressure Worth acting on
  • Shortness of breath Worth acting on
  • Liver problems Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on

Showing the 10 most notable of 34 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Tretinoin. Read the label on DailyMed › Where a percentage is shown, it is the share of 8,580 voluntary FDA FAERS reports for Tretinoin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Gamma-oryzanol’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Gamma-oryzanol side to compare — that is a limit of the record, not a statement that Gamma-oryzanol has no side effects.

How to take them

Some Tretinoin Products Have a Food Rule — Gamma-oryzanol Should Not Break It

At least one FDA label for a product containing Tretinoin says to take it with food. If you take Gamma-oryzanol on an empty stomach out of habit, keep them separate — and take Tretinoin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tretinoin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Take tretinoin capsules with a meal.

From the Dosage and Administration section of the FDA label we read for Tretinoin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Tretinoin

This page covers Gamma-oryzanol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tretinoin page lists 52 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Vitamin A (major), African Wild Potato (moderate), Alfalfa (moderate) and Angelica Archangelica (moderate).

By severity: 2 major · 37 moderate · 13 minor.

Open the Tretinoin interaction page

One more smart check

Taking Gamma-oryzanol as Part of a Dietary Supplement Product? Check It for Interactions

We hold 272 real supplement products containing Gamma-oryzanol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Gamma-oryzanol. Even though Gamma-oryzanol itself has no known interaction with Tretinoin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Gamma-oryzanol and Tretinoin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gamma-oryzanol
Top half

#683 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tretinoin
Steady interest

#2,444 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Gamma-oryzanol and Tretinoin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Gamma-oryzanol

What is Gamma-oryzanol?

  • High cholesterol
  • Menopausal symptoms
  • Athletic performance and muscle building
  • Mild anxiety
  • Skin protection (topical)

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The evidence is limited and mostly comes from small or older studies, so benefits are not well proven. It appears generally well tolerated, but talk with your pharmacist or doctor before using it.

Poaceae · Rice bran oil (derived from Oryza sativa bran) · Capsules, tablets, powder, topical creams

An interaction check asks whether these two react with each other — it does not ask whether Gamma-oryzanol is a good idea for someone in your situation. Here is what our Gamma-oryzanol record says about it on its own.

Gamma-oryzanol: dosing

There is no official or standardized dose for gamma-oryzanol. Doses used in research have varied widely, and what works for one use may not apply to another.The best approach is to follow the directions on the product label and not take more than recommended.

From our Gamma-oryzanol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Gamma-oryzanol monograph & all interactions
Medication

About Tretinoin

What Is Tretinoin Used For?

Brand names: Vesanoid, Retin-A, Renova, Altreno

Tretinoin cream 0.02% is approved to help lessen the look of fine facial wrinkles in people who also follow a comprehensive skin care and sun-avoidance program — including daily sunscreen, protective clothing, and moisturizers.

It's important to know what tretinoin does not do: it will not erase wrinkles, reverse sun damage, repair deeply weathered skin, or restore younger-looking skin. It has also not been shown to help with coarse or deep wrinkles, rough skin texture, dark spots, or sagging skin.

Most-Reported Side Effects for Tretinoin

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Vomiting 498 reports
Rash 477 reports
Nausea 453 reports
Headache 434 reports
Diarrhea 414 reports
See full Tretinoin drug information
Keep checking

Other Drugs & Gamma-oryzanol

Browse every other medication we’ve checked against Gamma-oryzanol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Gamma-oryzanol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Gamma-oryzanol list.

See the full Gamma-oryzanol interactions page
See every supplement checked against Tretinoin, ranked by severity
Sources

Sources & How We Checked

We checked Gamma-oryzanol against Tretinoin in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Gamma-oryzanol monograph › Uses, safety, and every drug interaction in one place Tretinoin supplement interactions › Every supplement checked against Tretinoin, ranked by severity Tretinoin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Gamma-oryzanol and Tretinoin Together: Common Questions

Is it safe to take Gamma-oryzanol with Tretinoin?
We do not list a known interaction between Gamma-oryzanol and Tretinoin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Gamma-oryzanol and Tretinoin at the same time of day?
At least one FDA label for a product containing Tretinoin says to take it with food. If you take Gamma-oryzanol on an empty stomach out of habit, keep them separate and take Tretinoin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Tretinoin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Tretinoin interact with any supplements?
Yes. Tretinoin has documented interactions with 52 supplements in our database — Gamma-oryzanol is not one of them. The Tretinoin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Tretinoin and Gamma-oryzanol?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.