Gamma-oryzanol + Tadalafil
Tadalafil brand names: Cialis, Tadliq.
We found no known interaction between Gamma-oryzanol and Tadalafil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Gamma-oryzanol and Tadalafil
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Tadalafil and Gamma-oryzanol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Gamma-oryzanol at all — not against Tadalafil, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Gamma-oryzanol safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
What Tadalafil Is Prescribed For, and What Gamma-oryzanol Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Tadalafil is a prescription medicine with approved uses on its FDA label. Gamma-oryzanol is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Tadalafil is prescribed for: Tadalafil tablets (including Cialis and generic tadalafil) are used to treat erectile dysfunction (ED), the symptoms of benign prostatic hyperplasia (BPH — an enlarged prostate), or both conditions together. When used with the drug finasteride to start BPH treatment, this combination is recommended for up to 26 weeks. Adcirca, Alyq (tablets), and Tadliq (oral suspension) are indicated specifically for pulmonary arterial hypertension (PAH — high blood pressure in the lungs), to improve the ability to exercise.
Gamma-oryzanol has been studied for:
-
Hypertension studied, not established Gamma-oryzanol has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Gamma-oryzanol for hypertension
Oral gamma-oryzanol has only been evaluated in combination with sesame oil; its benefits when used alone are unclear.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Tadalafil on your own; if you are taking Gamma-oryzanol for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Gamma-oryzanol or Tadalafil
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Gamma-oryzanol or Tadalafil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Which Medications Interact With Nitric Oxide Supplements? ›
- Can You Take L-Citrulline With Daily Tadalafil? ›
- Cialis With Beet Root Supplement Interaction Concerns ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Tadalafil
This page covers Gamma-oryzanol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tadalafil page lists 144 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Mistletoe (major), Grapefruit (major), Hawthorn (major) and St. John's Wort (major).
By severity: 5 major · 98 moderate · 41 minor.
From our pharmacist’s overview on the Tadalafil page
“Grapefruit juice is the first thing to know about if you take tadalafil (Cialis, Tadliq). It blocks CYP3A4, the enzyme that clears the drug, so blood levels climb and side effects like a steep drop in blood pressure become more likely.”
Reviewed by 2 · Jul 18, 2026
Taking Gamma-oryzanol as Part of a Dietary Supplement Product? Check It for Interactions
We hold 272 real supplement products containing Gamma-oryzanol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Gamma-oryzanol. Even though Gamma-oryzanol itself has no known interaction with Tadalafil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Gamma-oryzanol and Tadalafil Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#748 of 1,452 supplements looked up here in the last 7 days
#16 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Gamma-oryzanol and Tadalafil records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Gamma-oryzanol
What is Gamma-oryzanol?
- High cholesterol
- Menopausal symptoms
- Athletic performance and muscle building
- Mild anxiety
- Skin protection (topical)
Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The evidence is limited and mostly comes from small or older studies, so benefits are not well proven. It appears generally well tolerated, but talk with your pharmacist or doctor before using it.
Poaceae · Rice bran oil (derived from Oryza sativa bran) · Capsules, tablets, powder, topical creams
An interaction check asks whether these two react with each other — it does not ask whether Gamma-oryzanol is a good idea for someone in your situation. Here is what our Gamma-oryzanol record says about it on its own.
Gamma-oryzanol: dosing
There is no official or standardized dose for gamma-oryzanol. Doses used in research have varied widely, and what works for one use may not apply to another.The best approach is to follow the directions on the product label and not take more than recommended.
From our Gamma-oryzanol monograph — the full record covers uses, side effects and every documented interaction.
About Tadalafil
What Is Tadalafil Used For?
Brand names: Cialis, Tadliq
Tadalafil tablets (including Cialis and generic tadalafil) are used to treat erectile dysfunction (ED), the symptoms of benign prostatic hyperplasia (BPH — an enlarged prostate), or both conditions together. When used with the drug finasteride to start BPH treatment, this combination is recommended for up to 26 weeks.
Adcirca, Alyq (tablets), and Tadliq (oral suspension) are indicated specifically for pulmonary arterial hypertension (PAH — high blood pressure in the lungs), to improve the ability to exercise.
Most-Reported Side Effects for Tadalafil
From FAERS, the FDA’s public side-effect reporting system (99,210 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Gamma-oryzanol
Browse every other medication we’ve checked against Gamma-oryzanol — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Gamma-oryzanol against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Abemaciclib ›
- Hydroxyurea ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Warfarin Sodium ›
- Tirzepatide ›
- Prednisone ›
- Propranolol ›
- Bupropion ›
- Metformin ›
- Lisdexamfetamine ›
- Amoxicillin ›
- Lisinopril ›
- Acyclovir ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Fluoxetine ›
- Amphetamine ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Pregabalin ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Quetiapine ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Gamma-oryzanol list.
Sources & How We Checked
We checked Gamma-oryzanol against Tadalafil in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking Gamma-oryzanol and Tadalafil Together: Common Questions
Is it safe to take Gamma-oryzanol with Tadalafil?
Are Gamma-oryzanol and Tadalafil used for the same thing?
Does Tadalafil interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Tadalafil and Gamma-oryzanol?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.