Tadalafil

Tadalafil (Cialis) is used to treat erectile dysfunction (ED, impotence; inability to get or keep an erection), and the symptoms of benign prostatic hyperplasia (BPH; an enlarged prostate) which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency in adult men. Tadalafil (Adcirca) is used to improve the ability to exercise in people with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Tadalafil is in a class of medications called phosphodiesterase (PDE) inhibitors. It works to treat erectile dysfunction by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Tadalafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow more easily.

If you are taking tadalafil to treat erectile dysfunction, you should know that it does not cure erectile dysfunction or increase sexual desire. Tadalafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV).

Tadalafil comes as a tablet to take by mouth. It may be taken with or without food.

If you are taking tadalafil to treat erectile dysfunction, follow your doctor's directions and the guidelines in this paragraph. There are two different ways to take tadalafil, either daily or on an as needed basis. Talk to your doctor about which dosing schedule is right for you. Tadalafil is sometimes taken as needed, usually at least 30 minutes before sexual activity and not more often than once every 24 hours. Your doctor will help you decide the best time for you to take tadalafil before sexual activity. Tadalafil is also sometimes taken once a day every day without regard to timing of sexual activity. You may attempt sexual activity at any time between doses. If you are taking tadalafil on a regular schedule, take it at around the same time every day. If you have certain health conditions or are taking certain medications, your doctor may tell you to take tadalafil less often or may prescribe a lower dose to be taken once a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tadalafil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are taking tadalafil to treat PAH or BPH, follow your doctor's directions and the guidelines in this paragraph. You should take tadalafil one time a day. Take all of the tablets for your daily dose at one time each day; do not divide the tablets to take as separate doses. Take tadalafil at around the same time every day. If you are already taking medication to treat BPH, your doctor may tell you to stop taking your other medication at least one day before starting treatment with tadalafil. Follow your doctor's directions carefully, and ask your doctor or pharmacist to explain any part you do not understand.

If you are taking tadalafil for erectile dysfunction, your doctor will probably start you on an average dose of tadalafil and increase or decrease your dose depending on your response to the medication. Tell your doctor if tadalafil is not working well or if you are experiencing side effects.

If you are taking tadalafil for PAH, you should know that tadalafil controls PAH but does not cure it. Continue to take tadalafil even if you feel well. Do not stop taking tadalafil without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking tadalafil,

• tell your doctor and pharmacist if you are allergic to tadalafil, any other medications, or any of the ingredients in tadalafil tablets. Ask your pharmacist for a list of the ingredients.

• tell your doctor if you are taking or have recently taken riociguat (Adempas) or nitrates such as isosorbide dinitrate (Isordil), isosorbide mononitrate (Monoket), and nitroglycerin (Minitran, Nitro-Dur, Nitromist, Nitrostat, others). Nitrates come as tablets, sublingual (under the tongue) tablets, sprays, patches, pastes, and ointments. Ask your doctor if you are not sure whether any of your medications contain nitrates. Your doctor will probably tell you not to take tadalafil if you are taking nitrates.

• tell your doctor if you are taking street drugs containing nitrates ('poppers') such as amyl nitrate, butyl nitrate, or nitrite while taking tadalafil. Your doctor will probably tell you not to take tadalafil if you are taking street drugs containing nitrates.

• you should know that tadalafil is available under the brand names Adcirca and Cialis. You should only be treated with one of these products at a time.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: alpha blockers such as alfuzosin (Uroxatral), doxazosin (Cardura), dutasteride (Avodart, in Jalyn), prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax, in Jalyn), and terazosin; amiodarone (Cordarone, Pacerone); certain antifungals such as fluconazole (Diflucan), griseofulvin (Grifulvin, Gris-PEG), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegel), and voriconazole (Vfend); aprepitant (Emend); bosentan (Tracleer); carbamazepine (Carbatrol, Epitol, Tegretol, Teril, others); clarithromycin (Biaxin, in Prevpac); diltiazem (Cardizem, Cartia,Tiazac, others); efavirenz (Sustiva, in Atripla); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors including indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra), lovastatin (Altocor, in Advicor); medications for high blood pressure; nefazodone; nevirapine (Viramune); other medications or treatments for erectile dysfunction; other medications or treatments for PAH; phenobarbital; phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); sertraline (Zoloft); telithromycin (Ketek); and verapamil (Calan, Covera,Verelan, in Tarka). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor what herbal products you are taking, especially St. John's wort.

• tell your doctor if you smoke; if you have ever had an erection that lasted more than 4 hours; and if you have recently had diarrhea, vomiting, not been drinking enough fluids, or sweating a lot which may have caused dehydration (loss of a large amount of body fluids. Also tell your doctor if you have or have ever had pulmonary veno-occlusive disease (PVOD; blockage of veins in the lungs); any condition that affects the shape of the penis; diabetes; high cholesterol; high or low blood pressure; irregular heartbeat; a heart attack or heart failure; angina (chest pain); a stroke; ulcers in the stomach; a bleeding disorder; blood circulation problems; blood cell problems such as sickle cell anemia (a disease of the red blood cells), multiple myeloma (cancer of the plasma cells), or leukemia (cancer of the white blood cells); or heart, kidney, or liver disease. Also tell your doctor if you or any of your family members have or have ever had an eye disease such as retinitis pigmentosa (an inherited eye condition that causes loss of vision) or if you have ever had sudden severe vision loss, especially if you were told that the vision loss was caused by a blockage of blood flow to the nerves that help you see.

• if you are a woman and you are taking tadalafil to treat PAH, tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking tadalafil, call your doctor.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking tadalafil.

• talk to your doctor about the safe use of alcoholic beverages during your treatment with tadalafil. If you drink a large amount of alcohol (more than five glasses of wine or five shots of whiskey) while you are taking tadalafil you are more likely to experience certain side effects of tadalafil such as dizziness, headache, fast heartbeat, and low blood pressure.

• if you are taking tadalafil to treat erectile dysfunction, tell your doctor if you have ever been advised by a health care professional to avoid sexual activity for medical reasons or if you have ever experienced chest pain during sexual activity. Sexual activity may be a strain on your heart, especially if you have heart disease. If you experience chest pain, dizziness, or nausea during sexual activity, call your doctor immediately or get emergency medical treatment, and avoid sexual activity until your doctor tells you otherwise.

• tell all your health care providers that you are taking tadalafil. If you ever need emergency medical treatment for a heart problem, the health care providers who treat you will need to know when you last took tadalafil.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

If you are taking tadalafil for erectile dysfunction on a regular schedule, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose or more than one dose per day to make up for a missed one.

If you are taking tadalafil for PAH or BPH, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Tadalafil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache

  • indigestion or heartburn

  • nausea

  • diarrhea

  • flushing

  • pain in the stomach, back, muscles, arms, or legs

  • cough

• Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • sudden decrease or loss of vision (see below for more information)

  • blurred vision

  • changes in color vision (seeing a blue tinge on objects or having difficulty telling the difference between blue and green)

  • sudden decrease or loss of hearing (see below for more information)

  • ringing in ears

  • erection that lasts longer than 4 hours

  • dizziness

  • chest pain

  • hives

  • rash

  • difficulty breathing or swallowing

  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

  • blistering or peeling of skin

• Some patients experienced a sudden loss of some or all of their vision after they took tadalafil or other medications that are similar to tadalafil. The vision loss was permanent in some cases. It is not known if the vision loss was caused by the medication. If you experience a sudden loss of vision while you are taking tadalafil, call your doctor immediately or get emergency medical treatment. Do not take any more doses of tadalafil or similar medications such as sildenafil (Revatio, Viagra) or vardenafil (Levitra) until you talk to your doctor.

• Some patients experienced a sudden decrease or loss of hearing after they took tadalafil or other medications that are similar to tadalafil. The hearing loss usually involved only one ear and did not always improve when the medication was stopped. It is not known if the hearing loss was caused by the medication. If you experience a sudden loss of hearing, sometimes with ringing in the ears or dizziness, while you are taking tadalafil, call your doctor immediately. Do not take any more doses of tadalafil or similar medications such as sildenafil (Revatio, Viagra) or vardenafil (Levitra) until you talk to your doctor.

• Tadalafil may cause other side effects. Call your doctor if you have any unusual problems while taking this medication

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Delavirdine	Delavirdine The serum concentration of Tadalafil can be increased when it is combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Tadalafil can be decreased when combined with Nevirapine.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Tadalafil.
Candesartan	Candesartan Tadalafil may increase the antihypertensive activities of Candesartan.
Cilostazol	Cilostazol Tadalafil may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Clopidogrel	Clopidogrel The metabolism of Tadalafil can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The metabolism of Tadalafil can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Fenofibrate	Fenofibrate Tadalafil may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine	Guanfacine Guanfacine may increase the antihypertensive activities of Tadalafil.
Magnesium Hydroxide	Magnesium Hydroxide Tadalafil may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine	Methylergonovine Methylergometrine may decrease the antihypertensive activities of Tadalafil.
Mycophenolate	Mycophenolate Tadalafil may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan	Naratriptan Naratriptan may decrease the antihypertensive activities of Tadalafil.
Olsalazine	Olsalazine Olsalazine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Paregoric	Paregoric Morphine may increase the hypotensive activities of Tadalafil.
Penbutolol	Penbutolol Tadalafil may increase the antihypertensive activities of Acebutolol.
Potassium	Potassium Potassium may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone	Prednisone Prednisone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Ranitidine	Ranitidine Tadalafil may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Reserpine	Reserpine The metabolism of Reserpine can be increased when combined with Tadalafil.
Rizatriptan	Rizatriptan Tadalafil may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Sumatriptan	Sumatriptan Sumatriptan may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Tacrolimus	Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Tadalafil.
Tizanidine	Tizanidine Tizanidine may increase the hypotensive activities of Tadalafil.
Triamcinolone	Triamcinolone The metabolism of Tadalafil can be increased when combined with Triamcinolone.
Zolmitriptan	Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Tadalafil.
Ampicillin Injection	Ampicillin Injection Ampicillin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Doxycycline Injection	Doxycycline Injection Doxycycline may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Fluconazole Injection	Fluconazole Injection Fluconazole may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Foscarnet Injection	Foscarnet Injection Foscarnet may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Hydromorphone Injection	Hydromorphone Injection Hydromorphone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Levofloxacin Injection	Levofloxacin Injection Tadalafil may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection	Meperidine Injection Meperidine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Metoclopramide Injection	Metoclopramide Injection Tadalafil may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Metronidazole Injection	Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Tadalafil.
Morphine Injection	Morphine Injection Morphine may increase the hypotensive activities of Tadalafil.
Pamidronate Injection	Pamidronate Injection Pamidronic acid may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Vancomycin Injection	Vancomycin Injection Tadalafil may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine	Altretamine Amphetamine may increase the hypotensive activities of Tadalafil.
Cefuroxime	Cefuroxime Cefuroxime may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Cyclosporine	Cyclosporine The metabolism of Tadalafil can be decreased when combined with Cyclosporine.
Ondansetron	Ondansetron The metabolism of Ondansetron can be decreased when combined with Tadalafil.
Torsemide	Torsemide Tadalafil may increase the excretion rate of Torasemide which could result in a lower serum level and potentially a reduction in efficacy.
Olanzapine	Olanzapine The risk or severity of hypotension, dyspepsia, and headache can be increased when Olanzapine is combined with Tadalafil.
Eprosartan	Eprosartan Tadalafil may increase the antihypertensive activities of Eprosartan.
Meloxicam	Meloxicam The therapeutic efficacy of Tadalafil can be decreased when used in combination with Meloxicam.
Oxcarbazepine	Oxcarbazepine The metabolism of Tadalafil can be increased when combined with Oxcarbazepine.
Pantoprazole	Pantoprazole Pantoprazole may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Telmisartan	Telmisartan Tadalafil may increase the antihypertensive activities of Telmisartan.
Temozolomide	Temozolomide Tadalafil may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon	Zaleplon Tadalafil may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Anakinra	Anakinra The metabolism of Tadalafil can be increased when combined with Anakinra.
Linezolid	Linezolid Linezolid may increase the hypotensive activities of Tadalafil.
Trimipramine	Trimipramine The risk or severity of hypotension, dyspepsia, and headache can be increased when Trimipramine is combined with Tadalafil.
Etanercept Injection	Etanercept Injection The metabolism of Tadalafil can be increased when combined with Etanercept.
Modafinil	Modafinil The metabolism of Tadalafil can be increased when combined with Modafinil.
Perindopril	Perindopril Tadalafil may increase the antihypertensive activities of Perindopril.
Tenofovir	Tenofovir Tenofovir may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Sirolimus	Sirolimus The metabolism of Sirolimus can be decreased when combined with Tadalafil.
Dutasteride	Dutasteride The metabolism of Dutasteride can be decreased when combined with Tadalafil.
Epinephrine Injection	Epinephrine Injection Epinephrine may decrease the antihypertensive activities of Tadalafil.
Eplerenone	Eplerenone Eplerenone may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Olmesartan	Olmesartan Tadalafil may increase the antihypertensive activities of Olmesartan.
Zonisamide	Zonisamide Tadalafil may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Adalimumab Injection	Adalimumab Injection The metabolism of Tadalafil can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The risk or severity of hypotension can be increased when Aripiprazole is combined with Tadalafil.
Atomoxetine	Atomoxetine Atomoxetine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Dexmethylphenidate	Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Tadalafil.
Atazanavir	Atazanavir The serum concentration of Tadalafil can be increased when it is combined with Atazanavir.
Almotriptan	Almotriptan Almotriptan may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Eletriptan	Eletriptan Eletriptan may decrease the antihypertensive activities of Tadalafil.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Tadalafil.
Vardenafil	Vardenafil The risk or severity of adverse effects can be increased when Tadalafil is combined with Vardenafil.
Alfuzosin	Alfuzosin Alfuzosin may increase the hypotensive activities of Tadalafil.
Aprepitant	Aprepitant The metabolism of Tadalafil can be decreased when combined with Aprepitant.
Emtricitabine	Emtricitabine Tadalafil may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine	Memantine Tadalafil may decrease the excretion rate of Memantine which could result in a higher serum level.
Frovatriptan	Frovatriptan Frovatriptan may decrease the antihypertensive activities of Tadalafil.
Progesterone	Progesterone The metabolism of Tadalafil can be decreased when combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The metabolism of Tadalafil can be decreased when combined with Apomorphine.
Infliximab Injection	Infliximab Injection The metabolism of Tadalafil can be increased when combined with Infliximab.
Protriptyline	Protriptyline Protriptyline may decrease the antihypertensive activities of Tadalafil.
Duloxetine	Duloxetine Duloxetine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Norethindrone	Norethindrone The metabolism of Tadalafil can be decreased when combined with Norethisterone.
Tinidazole	Tinidazole Tadalafil may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Bosentan	Bosentan Bosentan may increase the antihypertensive activities of Tadalafil.
Cefditoren	Cefditoren Cefdinir may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Cyanocobalamin Injection	Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Erlotinib	Erlotinib The metabolism of Tadalafil can be decreased when combined with Erlotinib.
Eszopiclone	Eszopiclone Eszopiclone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Ganciclovir	Ganciclovir Tadalafil may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin	Ribavirin Ribavirin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Solifenacin	Solifenacin Solifenacin may decrease the antihypertensive activities of Tadalafil.
Valganciclovir	Valganciclovir Tadalafil may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole	Voriconazole The serum concentration of Tadalafil can be increased when it is combined with Voriconazole.
Adefovir	Adefovir Adefovir may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Dextroamphetamine	Dextroamphetamine Amphetamine may increase the hypotensive activities of Tadalafil.
Isocarboxazid	Isocarboxazid Isocarboxazid may increase the hypotensive activities of Tadalafil.
Ramelteon	Ramelteon Tadalafil may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Fentanyl	Fentanyl Fentanyl may decrease the antihypertensive activities of Tadalafil.
Pregabalin	Pregabalin Pregabalin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Phenylephrine	Phenylephrine The risk or severity of hypertension can be decreased when Phenylephrine is combined with Tadalafil.
Tipranavir	Tipranavir The serum concentration of Tadalafil can be increased when it is combined with Tipranavir.
Ranolazine	Ranolazine Ranolazine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Abatacept Injection	Abatacept Injection The metabolism of Tadalafil can be increased when combined with Abatacept.
Rasagiline	Rasagiline Tadalafil may increase the hypotensive activities of Rasagiline.
Imatinib	Imatinib The metabolism of Tadalafil can be decreased when combined with Imatinib.
Sitagliptin	Sitagliptin Tadalafil may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline	Varenicline Tadalafil may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib	Gefitinib The metabolism of Tadalafil can be decreased when combined with Gefitinib.
Albuterol	Albuterol Salbutamol may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Paliperidone	Paliperidone The risk or severity of hypotension, dyspepsia, and headache can be increased when Tadalafil is combined with Paliperidone.
Clofarabine Injection	Clofarabine Injection Clofarabine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Lubiprostone	Lubiprostone Tadalafil may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Posaconazole	Posaconazole The serum concentration of Tadalafil can be increased when it is combined with Posaconazole.
Rituximab Injection	Rituximab Injection Tadalafil may increase the hypotensive activities of Rituximab.
Aliskiren	Aliskiren Tadalafil may increase the antihypertensive activities of Aliskiren.
Darunavir	Darunavir The serum concentration of Darunavir can be increased when it is combined with Tadalafil.
Pemetrexed Injection	Pemetrexed Injection Tadalafil may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lisdexamfetamine	Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Tadalafil.
Nabilone	Nabilone Nabilone may increase the hypotensive activities of Tadalafil.
Sorafenib	Sorafenib The metabolism of Tadalafil can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib The metabolism of Sunitinib can be decreased when combined with Tadalafil.
Lapatinib	Lapatinib The metabolism of Lapatinib can be decreased when combined with Tadalafil.
Levocetirizine	Levocetirizine Tadalafil may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection	Pegaptanib Injection Tadalafil may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib	Dasatinib The metabolism of Dasatinib can be decreased when combined with Tadalafil.
Armodafinil	Armodafinil The metabolism of Tadalafil can be increased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection Tadalafil may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Tadalafil.
Lenalidomide	Lenalidomide Lenalidomide may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Nilotinib	Nilotinib The serum concentration of Tadalafil can be increased when it is combined with Nilotinib.
Budesonide	Budesonide The metabolism of Tadalafil can be increased when combined with Budesonide.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Tadalafil can be decreased when combined with Chloramphenicol.
Desmopressin	Desmopressin Desmopressin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Doripenem Injection	Doripenem Injection Tadalafil may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection	Arsenic Trioxide Injection Arsenic trioxide may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Sapropterin	Sapropterin Sapropterin may increase the hypotensive activities of Tadalafil.
Desvenlafaxine	Desvenlafaxine Tadalafil may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level.
Cevimeline	Cevimeline Cevimeline may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Nebivolol	Nebivolol Tadalafil may increase the antihypertensive activities of Nebivolol.
Tretinoin	Tretinoin The metabolism of Tadalafil can be decreased when combined with Tretinoin.
Certolizumab Injection	Certolizumab Injection The metabolism of Tadalafil can be increased when combined with Certolizumab pegol.
Irinotecan Injection	Irinotecan Injection The metabolism of Tadalafil can be decreased when combined with Irinotecan.
Daptomycin Injection	Daptomycin Injection Daptomycin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Praziquantel	Praziquantel The metabolism of Praziquantel can be decreased when combined with Tadalafil.
Methylnaltrexone Injection	Methylnaltrexone Injection Tadalafil may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Silodosin	Silodosin The risk or severity of hypotension, dyspepsia, and headache can be increased when Tadalafil is combined with Silodosin.
Midazolam	Midazolam Midazolam may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Dexrazoxane Injection	Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Milnacipran	Milnacipran Tadalafil may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Plerixafor Injection	Plerixafor Injection Tadalafil may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine	Fesoterodine Tadalafil may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Betaxolol	Betaxolol Tadalafil may increase the antihypertensive activities of Betaxolol.
Iloperidone	Iloperidone The risk or severity of hypotension, dyspepsia, and headache can be increased when Tadalafil is combined with Iloperidone.
Prasugrel	Prasugrel Tadalafil may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone	Dronedarone The metabolism of Tadalafil can be decreased when combined with Dronedarone.
Pralatrexate Injection	Pralatrexate Injection Tadalafil may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection	Palonosetron Injection Palonosetron may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Saxagliptin	Saxagliptin Tadalafil may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection	Telavancin Injection Tadalafil may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Tadalafil.
Topotecan	Topotecan Tadalafil may decrease the excretion rate of Topotecan which could result in a higher serum level.
Golimumab Injection	Golimumab Injection The metabolism of Tadalafil can be increased when combined with Golimumab.
Asenapine	Asenapine The risk or severity of hypotension, dyspepsia, and headache can be increased when Asenapine is combined with Tadalafil.
Levonorgestrel	Levonorgestrel The metabolism of Tadalafil can be decreased when combined with Levonorgestrel.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Tadalafil can be increased when combined with Tocilizumab.
Dalfampridine	Dalfampridine Tadalafil may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Tadalafil.
Ceftaroline Injection	Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Lurasidone	Lurasidone Lurasidone may decrease the antihypertensive activities of Tadalafil.
Acetaminophen Injection	Acetaminophen Injection Acetaminophen may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Vilazodone	Vilazodone Vilazodone may decrease the antihypertensive activities of Tadalafil.
Ipilimumab Injection	Ipilimumab Injection Tadalafil may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection	Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Terbutaline Injection	Terbutaline Injection Tadalafil may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Azilsartan	Azilsartan Azilsartan medoxomil may increase the hypotensive activities of Tadalafil.
Roflumilast	Roflumilast Tadalafil may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Tadalafil can be decreased when combined with Cyclophosphamide.
Rivaroxaban	Rivaroxaban Tadalafil may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ruxolitinib	Ruxolitinib Tadalafil may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam	Clobazam Clobazam may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Ivacaftor	Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Tadalafil.
Deferiprone	Deferiprone Tadalafil may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Tadalafil.
Crizotinib	Crizotinib The metabolism of Tadalafil can be decreased when combined with Crizotinib.
Cabergoline	Cabergoline Cabergoline may decrease the antihypertensive activities of Tadalafil.
Naloxone Injection	Naloxone Injection The serum concentration of Tadalafil can be increased when it is combined with Naloxone.
Ambrisentan	Ambrisentan Tadalafil may increase the antihypertensive activities of Ambrisentan.
Fondaparinux Injection	Fondaparinux Injection Fondaparinux may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Iloprost	Iloprost Iloprost may increase the hypotensive activities of Tadalafil.
Enzalutamide	Enzalutamide Tadalafil may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron	Mirabegron Mirabegron may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Teduglutide Injection	Teduglutide Injection Tadalafil may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin	Alogliptin Tadalafil may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Tadalafil.
Pomalidomide	Pomalidomide Tadalafil may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Tadalafil.
Apixaban	Apixaban The metabolism of Apixaban can be decreased when combined with Tadalafil.
Canagliflozin	Canagliflozin Canagliflozin may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide	Methazolamide Methazolamide may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Trametinib	Trametinib Tadalafil may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran	Levomilnacipran Tadalafil may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
Ertapenem Injection	Ertapenem Injection Ertapenem may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Vortioxetine	Vortioxetine Tadalafil may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Perampanel	Perampanel The metabolism of Perampanel can be decreased when combined with Tadalafil.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Tadalafil.
Avanafil	Avanafil The risk or severity of adverse effects can be increased when Avanafil is combined with Tadalafil.
Ketorolac Injection	Ketorolac Injection Ketorolac may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Obinutuzumab Injection	Obinutuzumab Injection Tadalafil may increase the hypotensive activities of Obinutuzumab.
Sofosbuvir	Sofosbuvir Tadalafil may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin	Dapagliflozin Dapagliflozin may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast	Apremilast The metabolism of Tadalafil can be increased when combined with Apremilast.
Droxidopa	Droxidopa Tadalafil may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Siltuximab Injection	Siltuximab Injection The metabolism of Tadalafil can be increased when combined with Siltuximab.
Testosterone Injection	Testosterone Injection Testosterone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Empagliflozin	Empagliflozin Empagliflozin may increase the hypotensive activities of Tadalafil.
Edoxaban	Edoxaban Tadalafil may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Olaparib	Olaparib The metabolism of Olaparib can be decreased when combined with Tadalafil.
Methamphetamine	Methamphetamine Tadalafil may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon	Tasimelteon Tadalafil may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat	Riociguat The risk or severity of hypotension can be increased when Tadalafil is combined with Riociguat.
Secukinumab Injection	Secukinumab Injection The metabolism of Tadalafil can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The risk or severity of hypotension, dyspepsia, and headache can be increased when Risperidone is combined with Tadalafil.
Dinutuximab Injection	Dinutuximab Injection Dinutuximab may increase the hypotensive activities of Tadalafil.
Haloperidol Injection	Haloperidol Injection The serum concentration of Tadalafil can be increased when it is combined with Haloperidol.
Amiloride	Amiloride Amiloride may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan	Macitentan Tadalafil may increase the antihypertensive activities of Macitentan.
Flibanserin	Flibanserin Flibanserin may decrease the antihypertensive activities of Tadalafil.
Daclatasvir	Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Tadalafil.
Brexpiprazole	Brexpiprazole The risk or severity of hypotension, dyspepsia, and headache can be increased when Brexpiprazole is combined with Tadalafil.
Ziprasidone Injection	Ziprasidone Injection Ziprasidone may increase the antihypertensive activities of Tadalafil.
Cariprazine	Cariprazine Cariprazine may decrease the antihypertensive activities of Tadalafil.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Tadalafil may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Ixazomib	Ixazomib Tadalafil may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad	Lesinurad Tadalafil may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Tadalafil can be increased when combined with Dexamethasone.
Brivaracetam Injection	Brivaracetam Injection Tadalafil may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Cobicistat	Cobicistat The serum concentration of Tadalafil can be increased when it is combined with Cobicistat.
Midodrine	Midodrine Midodrine may decrease the antihypertensive activities of Tadalafil.
Selexipag	Selexipag Tadalafil may increase the antihypertensive activities of Selexipag.
Furosemide Injection	Furosemide Injection Furosemide may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib	Rucaparib The metabolism of Tadalafil can be decreased when combined with Rucaparib.
Lixisenatide Injection	Lixisenatide Injection Tadalafil may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib	Ribociclib The serum concentration of Tadalafil can be increased when it is combined with Ribociclib.
Doxepin (Insomnia)	Doxepin (Insomnia) The risk or severity of hypotension, dyspepsia, and headache can be increased when Doxepin is combined with Tadalafil.
Deutetrabenazine	Deutetrabenazine Tadalafil may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine	Valbenazine Tadalafil may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort	Deflazacort The metabolism of Tadalafil can be increased when combined with Deflazacort.
Safinamide	Safinamide The metabolism of Tadalafil can be decreased when combined with Safinamide.
Naldemedine	Naldemedine Tadalafil may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin	Midostaurin The serum concentration of Tadalafil can be increased when it is combined with Midostaurin.
Benznidazole	Benznidazole Tadalafil may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Tadalafil.
Delafloxacin	Delafloxacin Tadalafil may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Acalabrutinib	Acalabrutinib The metabolism of Tadalafil can be decreased when combined with Acalabrutinib.
Letermovir	Letermovir The metabolism of Tadalafil can be decreased when combined with Letermovir.
Ertugliflozin	Ertugliflozin Ertugliflozin may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection	Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Tadalafil.
Apalutamide	Apalutamide Tadalafil may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Fostamatinib	Fostamatinib The risk or severity of adverse effects can be increased when Fostamatinib is combined with Tadalafil.
Baricitinib	Baricitinib Tadalafil may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine	Lofexidine Tadalafil may increase the antihypertensive activities of Lofexidine.
Plazomicin Injection	Plazomicin Injection Tadalafil may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Doravirine	Doravirine The metabolism of Doravirine can be decreased when combined with Tadalafil.
Cannabidiol	Cannabidiol The metabolism of Tadalafil can be decreased when combined with Cannabidiol.
Stiripentol	Stiripentol The serum concentration of Tadalafil can be increased when it is combined with Stiripentol.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Tadalafil.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Tadalafil.
Prucalopride	Prucalopride Tadalafil may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Tadalafil can be increased when combined with Emapalumab.
Siponimod	Siponimod Siponimod may decrease the antihypertensive activities of Tadalafil.
Acyclovir Ophthalmic	Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Solriamfetol	Solriamfetol Tadalafil may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Tadalafil.
Pitolisant	Pitolisant The serum concentration of Tadalafil can be decreased when it is combined with Pitolisant.
Phenytoin Injection	Phenytoin Injection The metabolism of Tadalafil can be increased when combined with Phenytoin.
Cenobamate	Cenobamate The serum concentration of Tadalafil can be decreased when it is combined with Cenobamate.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Tadalafil.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Tadalafil.
Selpercatinib	Selpercatinib Selpercatinib may decrease the antihypertensive activities of Tadalafil.
Lemborexant	Lemborexant The metabolism of Lemborexant can be decreased when combined with Tadalafil.
Pralsetinib	Pralsetinib The metabolism of Tadalafil can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Tadalafil can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection	Naxitamab-gqgk Injection Naxitamab may decrease the antihypertensive activities of Tadalafil.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine	Viloxazine Tadalafil may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Fenoprofen	Fenoprofen Fenoprofen may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Indomethacin	Indomethacin Indomethacin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Mefenamic Acid	Mefenamic Acid Mefenamic acid may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Naproxen	Naproxen Naproxen may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Tolmetin	Tolmetin Tolmetin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Sulindac	Sulindac Sulindac may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Trazodone	Trazodone The risk or severity of hypotension, dyspepsia, and headache can be increased when Trazodone is combined with Tadalafil.
Isotretinoin	Isotretinoin Tadalafil may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate	Sucralfate Sucralfate may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Floxuridine	Floxuridine Floxuridine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Phenobarbital	Phenobarbital The metabolism of Tadalafil can be increased when combined with Phenobarbital.
Metaxalone	Metaxalone Metaxalone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Methotrexate Injection	Methotrexate Injection Methotrexate may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Diethylpropion	Diethylpropion Diethylpropion may decrease the antihypertensive activities of Tadalafil.
Chlorpromazine	Chlorpromazine The risk or severity of hypotension, dyspepsia, and headache can be increased when Chlorpromazine is combined with Tadalafil.
Diazepam	Diazepam Tadalafil may decrease the excretion rate of Diazepam which could result in a higher serum level.
Oxazepam	Oxazepam Tadalafil may decrease the excretion rate of Oxazepam which could result in a higher serum level.
Flurazepam	Flurazepam Flurazepam may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Clorazepate	Clorazepate Clorazepic acid may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Lorazepam	Lorazepam Lorazepam may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Phenoxybenzamine	Phenoxybenzamine The risk or severity of hypotension, dyspepsia, and headache can be increased when Tadalafil is combined with Phenoxybenzamine.
Carmustine	Carmustine Carmustine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Amantadine	Amantadine Tadalafil may decrease the excretion rate of Amantadine which could result in a higher serum level.
Codeine	Codeine Codeine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Bromocriptine	Bromocriptine The risk or severity of hypotension, dyspepsia, and headache can be increased when Bromocriptine is combined with Tadalafil.
Metaproterenol	Metaproterenol Orciprenaline may decrease the antihypertensive activities of Tadalafil.
Tranylcypromine	Tranylcypromine Tranylcypromine may increase the hypotensive activities of Tadalafil.
Phenelzine	Phenelzine The metabolism of Tadalafil can be decreased when combined with Phenelzine.
Procarbazine	Procarbazine Procarbazine may increase the hypotensive activities of Tadalafil.
Ergoloid Mesylates	Ergoloid Mesylates Ergoloid mesylate may decrease the antihypertensive activities of Tadalafil.
Tetracycline	Tetracycline Tetracycline may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Thioridazine	Thioridazine The risk or severity of hypotension, dyspepsia, and headache can be increased when Tadalafil is combined with Thioridazine.
Trifluoperazine	Trifluoperazine The risk or severity of hypotension, dyspepsia, and headache can be increased when Tadalafil is combined with Trifluoperazine.
Bleomycin	Bleomycin Bleomycin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Dapsone	Dapsone The metabolism of Tadalafil can be decreased when combined with Dapsone.
Sulfadiazine	Sulfadiazine Sulfadiazine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Oxycodone	Oxycodone The metabolism of Tadalafil can be decreased when combined with Oxycodone.
Methadone	Methadone Methadone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Oxybutynin	Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Tadalafil.
Benztropine	Benztropine Benzatropine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Maprotiline	Maprotiline Tadalafil may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Ibuprofen	Ibuprofen The therapeutic efficacy of Tadalafil can be decreased when used in combination with Ibuprofen.
Azathioprine	Azathioprine Tadalafil may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Phentermine	Phentermine Phentermine may decrease the antihypertensive activities of Tadalafil.
Methylphenidate	Methylphenidate Methylphenidate may decrease the antihypertensive activities of Tadalafil.
Amoxapine	Amoxapine The risk or severity of hypotension, dyspepsia, and headache can be increased when Tadalafil is combined with Amoxapine.
Sulfasalazine	Sulfasalazine Sulfasalazine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Hydrocortisone	Hydrocortisone The metabolism of Tadalafil can be decreased when combined with Hydrocortisone.
Phenazopyridine	Phenazopyridine Phenazopyridine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Carbamazepine	Carbamazepine The metabolism of Tadalafil can be decreased when combined with Carbamazepine.
Methyldopa	Methyldopa Tadalafil may increase the antihypertensive activities of Methyldopa.
Clonidine	Clonidine The risk or severity of hypotension can be increased when Clonidine is combined with Tadalafil.
Prazosin	Prazosin The risk or severity of hypotension can be increased when Prazosin is combined with Tadalafil.
Hydralazine	Hydralazine Tadalafil may increase the antihypertensive activities of Hydralazine.
Cimetidine	Cimetidine The metabolism of Tadalafil can be decreased when combined with Cimetidine.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Warfarin	Warfarin Tadalafil may decrease the excretion rate of Warfarin which could result in a higher serum level.
Clonazepam	Clonazepam Tadalafil may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Loperamide	Loperamide The serum concentration of Tadalafil can be increased when it is combined with Loperamide.
Promethazine	Promethazine Tadalafil may decrease the excretion rate of Promethazine which could result in a higher serum level.
Meclofenamate	Meclofenamate Meclofenamic acid may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Daunorubicin	Daunorubicin The metabolism of Tadalafil can be increased when combined with Daunorubicin.
Nitrofurantoin	Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Digoxin	Digoxin Tadalafil may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine	Chloroquine Chloroquine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Quinine	Quinine The metabolism of Tadalafil can be decreased when combined with Quinine.
Triamterene	Triamterene Triamterene may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Chlorothiazide	Chlorothiazide The therapeutic efficacy of Chlorothiazide can be increased when used in combination with Tadalafil.
Chlorthalidone	Chlorthalidone Tadalafil may increase the excretion rate of Chlorthalidone which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone	Metolazone Tadalafil may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide	Isosorbide The risk or severity of hypotension can be increased when Tadalafil is combined with Isosorbide.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Tadalafil.
Secobarbital	Secobarbital Secobarbital may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Desipramine	Desipramine Desipramine may decrease the antihypertensive activities of Tadalafil.
Amitriptyline	Amitriptyline The risk or severity of hypotension, dyspepsia, and headache can be increased when Amitriptyline is combined with Tadalafil.
Imipramine	Imipramine The risk or severity of hypotension, dyspepsia, and headache can be increased when Imipramine is combined with Tadalafil.
Probenecid	Probenecid Tadalafil may decrease the excretion rate of Probenecid which could result in a higher serum level.
Quinidine	Quinidine Tadalafil may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide	Procainamide Tadalafil may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid	Isoniazid Tadalafil may decrease the excretion rate of Isoniazid which could result in a higher serum level.
Pyrazinamide	Pyrazinamide Pyrazinamide may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Rifampin	Rifampin The metabolism of Tadalafil can be increased when combined with Rifampicin.
Disopyramide	Disopyramide Disopyramide may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Tamoxifen	Tamoxifen The metabolism of Tadalafil can be decreased when combined with Tamoxifen.
Butabarbital	Butabarbital Butabarbital may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Liothyronine	Liothyronine Liothyronine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Methimazole	Methimazole The serum concentration of Tadalafil can be increased when it is combined with Methimazole.
Chlorpropamide	Chlorpropamide Chlorpropamide may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Tolbutamide	Tolbutamide Tadalafil may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide	Tolazamide Tadalafil may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Dextromethorphan	Dextromethorphan The metabolism of Tadalafil can be decreased when combined with Dextromethorphan.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Tadalafil.
Chlorpheniramine	Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Tadalafil.
Ethambutol	Ethambutol Ethambutol may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Methyclothiazide	Methyclothiazide The therapeutic efficacy of Tadalafil can be increased when used in combination with Methyclothiazide.
Hydrochlorothiazide	Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Tadalafil.
Chlorzoxazone	Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Pyridoxine	Pyridoxine Pyridoxine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Folic Acid	Folic Acid Folic acid may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Disulfiram	Disulfiram The metabolism of Disulfiram can be decreased when combined with Tadalafil.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) Propranolol may increase the antihypertensive activities of Tadalafil.
Minoxidil	Minoxidil Tadalafil may increase the antihypertensive activities of Minoxidil.
Pseudoephedrine	Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Tadalafil.
Nortriptyline	Nortriptyline The risk or severity of hypotension, dyspepsia, and headache can be increased when Nortriptyline is combined with Tadalafil.
Spironolactone	Spironolactone Spironolactone may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection	Amphotericin B Injection Amphotericin B may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Phytonadione	Phytonadione Tadalafil may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection	Amikacin Injection Amikacin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Nadolol	Nadolol Tadalafil may increase the antihypertensive activities of Nadolol.
Allopurinol	Allopurinol Allopurinol may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Flavoxate	Flavoxate Tadalafil may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Papaverine	Papaverine Papaverine may increase the hypotensive activities of Tadalafil.
Colchicine	Colchicine Tadalafil may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor	Cefaclor Cefaclor may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Cefadroxil	Cefadroxil Cefadroxil may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection Cefazolin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Cephalexin	Cephalexin Cephalexin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Cefoxitin Injection	Cefoxitin Injection Cefoxitin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Dacarbazine	Dacarbazine Tadalafil may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide	Acetazolamide Acetazolamide may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection	Cefotaxime Injection Cefotaxime may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Calcitonin Salmon Injection	Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Ketoconazole	Ketoconazole The serum concentration of Tadalafil can be increased when it is combined with Ketoconazole.
Pyrantel	Pyrantel Tadalafil may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Vincristine Injection	Vincristine Injection The metabolism of Tadalafil can be decreased when combined with Vincristine.
Captopril	Captopril Tadalafil may increase the antihypertensive activities of Captopril.
Dipyridamole	Dipyridamole The risk or severity of adverse effects can be increased when Tadalafil is combined with Dipyridamole.
Isoxsuprine	Isoxsuprine Isoxsuprine may decrease the antihypertensive activities of Tadalafil.
Ethacrynic Acid	Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Colistimethate Injection	Colistimethate Injection Colistimethate may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Metoprolol	Metoprolol Metoprolol may increase the antihypertensive activities of Tadalafil.
Hydroxyzine	Hydroxyzine The metabolism of Tadalafil can be decreased when combined with Hydroxyzine.
Aspirin	Aspirin Acetylsalicylic acid may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Salsalate	Salsalate Salsalate may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Alprazolam	Alprazolam Alprazolam may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Temazepam	Temazepam Temazepam may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Triazolam	Triazolam Tadalafil may decrease the excretion rate of Triazolam which could result in a higher serum level.
Dicyclomine	Dicyclomine Dicyclomine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Propantheline	Propantheline Propantheline may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Trimethoprim	Trimethoprim Trimethoprim may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Diltiazem	Diltiazem The metabolism of Tadalafil can be decreased when combined with Diltiazem.
Nifedipine	Nifedipine The risk or severity of hypotension can be increased when Nifedipine is combined with Tadalafil.
Timolol	Timolol Tadalafil may increase the antihypertensive activities of Timolol.
Verapamil	Verapamil The metabolism of Tadalafil can be decreased when combined with Verapamil.
Atenolol	Atenolol Tadalafil may increase the antihypertensive activities of Atenolol.
Pindolol	Pindolol Tadalafil may increase the antihypertensive activities of Pindolol.
Cisplatin Injection	Cisplatin Injection Tadalafil may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal	Diflunisal Diflunisal may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Piroxicam	Piroxicam Piroxicam may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Bumetanide	Bumetanide Tadalafil may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide	Etoposide The metabolism of Tadalafil can be decreased when combined with Etoposide.
Glyburide	Glyburide The metabolism of Glyburide can be decreased when combined with Tadalafil.
Glipizide	Glipizide Tadalafil may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide	Indapamide The therapeutic efficacy of Tadalafil can be increased when used in combination with Indapamide.
Amoxicillin	Amoxicillin Tadalafil may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection	Oxacillin Injection Oxacillin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Pentoxifylline	Pentoxifylline Pentoxifylline may increase the hypotensive activities of Tadalafil.
Pentamidine Injection	Pentamidine Injection Pentamidine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Ceftriaxone Injection	Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Labetalol	Labetalol The risk or severity of hypotension, dyspepsia, and headache can be increased when Tadalafil is combined with Labetalol.
Auranofin	Auranofin Tadalafil may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection	Leuprolide Injection Leuprolide may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Gemfibrozil	Gemfibrozil Tadalafil may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Guanabenz	Guanabenz Tadalafil may increase the antihypertensive activities of Guanabenz.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Ceftazidime Injection	Ceftazidime Injection Ceftazidime may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Ketoprofen	Ketoprofen Ketoprofen may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Cefotetan Injection	Cefotetan Injection Cefotetan may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Pimozide	Pimozide The metabolism of Pimozide can be decreased when combined with Tadalafil.
Enalapril	Enalapril Enalapril may increase the antihypertensive activities of Tadalafil.
Flurbiprofen	Flurbiprofen Flurbiprofen may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Amiodarone	Amiodarone Amiodarone may increase the hypotensive activities of Tadalafil.
Aztreonam Injection	Aztreonam Injection Aztreonam may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Buspirone	Buspirone Buspirone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Lovastatin	Lovastatin The metabolism of Tadalafil can be decreased when combined with Lovastatin.
Ciprofloxacin	Ciprofloxacin The metabolism of Tadalafil can be decreased when combined with Ciprofloxacin.
Mesalamine	Mesalamine Mesalazine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Diclofenac	Diclofenac The therapeutic efficacy of Tadalafil can be decreased when used in combination with Diclofenac.
Nimodipine	Nimodipine Nimodipine may increase the antihypertensive activities of Tadalafil.
Clozapine	Clozapine The risk or severity of hypotension, dyspepsia, and headache can be increased when Clozapine is combined with Tadalafil.
Estazolam	Estazolam Tadalafil may decrease the excretion rate of Estazolam which could result in a higher serum level.
Didanosine	Didanosine Tadalafil may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection	Pentostatin Injection Pentostatin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Clarithromycin	Clarithromycin The serum concentration of Tadalafil can be increased when it is combined with Clarithromycin.
Benazepril	Benazepril Tadalafil may increase the antihypertensive activities of Benazepril.
Etodolac	Etodolac Etodolac may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Felodipine	Felodipine Tadalafil may increase the antihypertensive activities of Felodipine.
Fosinopril	Fosinopril Tadalafil may increase the antihypertensive activities of Fosinopril.
Nabumetone	Nabumetone Nabumetone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Quinapril	Quinapril Tadalafil may increase the antihypertensive activities of Quinapril.
Ramipril	Ramipril Tadalafil may increase the antihypertensive activities of Ramipril.
Simvastatin	Simvastatin The metabolism of Tadalafil can be decreased when combined with Simvastatin.
Amlodipine	Amlodipine Amlodipine may increase the antihypertensive activities of Tadalafil.
Teniposide Injection	Teniposide Injection The metabolism of Tadalafil can be decreased when combined with Teniposide.
Itraconazole	Itraconazole The metabolism of Tadalafil can be decreased when combined with Itraconazole.
Lisinopril	Lisinopril Tadalafil may increase the antihypertensive activities of Lisinopril.
Oxaprozin	Oxaprozin Oxaprozin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Sotalol	Sotalol Sotalol may increase the hypotensive activities of Tadalafil.
Bisoprolol	Bisoprolol Bisoprolol may increase the antihypertensive activities of Tadalafil.
Doxazosin	Doxazosin The risk or severity of hypotension can be increased when Tadalafil is combined with Doxazosin.
Terazosin	Terazosin The risk or severity of hypotension, dyspepsia, and headache can be increased when Tadalafil is combined with Terazosin.
Isradipine	Isradipine Isradipine may increase the antihypertensive activities of Tadalafil.
Cisapride	Cisapride The metabolism of Tadalafil can be decreased when combined with Cisapride.
Fluvastatin	Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Tadalafil.
Venlafaxine	Venlafaxine Venlafaxine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Fluvoxamine	Fluvoxamine Fluvoxamine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Nefazodone	Nefazodone The serum concentration of Tadalafil can be increased when it is combined with Nefazodone.
Lamotrigine	Lamotrigine Lamotrigine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Losartan	Losartan Losartan may increase the antihypertensive activities of Tadalafil.
Valacyclovir	Valacyclovir Valaciclovir may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Tramadol	Tramadol Tramadol may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Carboplatin Injection	Carboplatin Injection Carboplatin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Moexipril	Moexipril Tadalafil may increase the antihypertensive activities of Moexipril.
Alprostadil Urogenital	Alprostadil Urogenital The risk or severity of hypotension and priapism can be increased when Tadalafil is combined with Alprostadil.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Tadalafil.
Nicardipine	Nicardipine The risk or severity of hypotension, dyspepsia, and headache can be increased when Nicardipine is combined with Tadalafil.
Bupropion	Bupropion Tadalafil may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine	Ticlopidine Ticlopidine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Saquinavir	Saquinavir The serum concentration of Saquinavir can be increased when it is combined with Tadalafil.
Metformin	Metformin Metformin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Nisoldipine	Nisoldipine Nisoldipine may increase the antihypertensive activities of Tadalafil.
Lamivudine	Lamivudine Lamivudine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Amifostine Injection	Amifostine Injection Tadalafil may increase the hypotensive activities of Amifostine.
Acarbose	Acarbose Acarbose may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Gemcitabine Injection	Gemcitabine Injection Gemcitabine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Indinavir	Indinavir The metabolism of Tadalafil can be decreased when combined with Indinavir.
Ritonavir	Ritonavir The serum concentration of Tadalafil can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Tadalafil.
Cidofovir Injection	Cidofovir Injection Cidofovir may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Meropenem Injection	Meropenem Injection Meropenem may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Clomipramine	Clomipramine Clomipramine may decrease the antihypertensive activities of Tadalafil.
Fosfomycin	Fosfomycin Tadalafil may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine	Mirtazapine Mirtazapine may decrease the antihypertensive activities of Tadalafil.
Trandolapril	Trandolapril Tadalafil may increase the antihypertensive activities of Trandolapril.
Topiramate	Topiramate Topiramate may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Valsartan	Valsartan Tadalafil may increase the antihypertensive activities of Valsartan.
Pramipexole	Pramipexole Pramipexole may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Nelfinavir	Nelfinavir The metabolism of Tadalafil can be decreased when combined with Nelfinavir.
Carvedilol	Carvedilol The risk or severity of hypotension, dyspepsia, and headache can be increased when Tadalafil is combined with Carvedilol.
Nilutamide	Nilutamide Nilutamide may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Flutamide	Flutamide Flutamide may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Selegiline	Selegiline Selegiline may increase the hypotensive activities of Tadalafil.
Propafenone	Propafenone Propafenone may decrease the antihypertensive activities of Tadalafil.
Irbesartan	Irbesartan Irbesartan may increase the antihypertensive activities of Tadalafil.
Tamsulosin	Tamsulosin The risk or severity of hypotension, dyspepsia, and headache can be increased when Tamsulosin is combined with Tadalafil.
Ropinirole	Ropinirole Ropinirole may increase the hypotensive activities of Tadalafil.
Finasteride	Finasteride The metabolism of Finasteride can be decreased when combined with Tadalafil.
Quetiapine	Quetiapine Tadalafil may increase the hypotensive activities of Quetiapine.
Cefepime Injection	Cefepime Injection Cefepime may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Cefprozil	Cefprozil Cefprozil may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Cefpodoxime	Cefpodoxime Cefpodoxime may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Cetirizine	Cetirizine Cetirizine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Tolcapone	Tolcapone Tolcapone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Capecitabine	Capecitabine Tadalafil may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Efavirenz	Efavirenz The serum concentration of Tadalafil can be increased when it is combined with Efavirenz.
Abacavir	Abacavir Tadalafil may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil	Sildenafil The risk or severity of adverse effects can be increased when Sildenafil is combined with Tadalafil.
Celecoxib	Celecoxib The therapeutic efficacy of Tadalafil can be decreased when used in combination with Celecoxib.
Rosiglitazone	Rosiglitazone Rosiglitazone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Tolterodine	Tolterodine Tadalafil may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Thalidomide	Thalidomide The metabolism of Tadalafil can be increased when combined with Thalidomide.
Oseltamivir	Oseltamivir Oseltamivir may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Balsalazide	Balsalazide Balsalazide may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Nateglinide	Nateglinide Nateglinide may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Rabeprazole	Rabeprazole Tadalafil may decrease the excretion rate of Rabeprazole which could result in a higher serum level.