Ivacaftor

Generic name: Pronounced as (eye'' va kaf' tor)
Brand names
  • Kalydeco®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 11/15/2020

Ivacaftor is used to treat certain types of cystic fibrosis (an inborn disease that causes problems with breathing, digestion, and reproduction) in adults and children 4 months of age and older. Ivacaftor should be used only in people with a certain genetic make-up. Your doctor may order a blood test to help decide if this medication is right for you. Ivacaftor is in a class of medications called cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. It works by improving the function of a protein in the body to decrease the build-up of thick mucus in the lungs and improving other symptoms of cystic fibrosis.

Ivacaftor comes as a tablet and as granules to take by mouth. It is usually taken with fatty foods twice a day, 12 hours apart. Take ivacaftor at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ivacaftor exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

To prepare a dose of ivacaftor granules, mix the entire packet of granules in 1 teaspoon (5 mL) of cold or room temperature soft food or liquid such as yogurt, applesauce, water, milk, baby formula, breast milk, or juice. Take the mixture within 1 hour of mixing the granules with food or a liquid.

Take each dose of ivacaftor with a fatty food such as eggs, butter, peanut butter, cheese pizza, whole-milk dairy products (such as whole milk, cheese, and yogurt), baby formula, and breast milk. Talk to your doctor about other fatty foods to eat with ivacaftor.

Ivacaftor controls cystic fibrosis but does not cure it. Continue to take ivacaftor even if you feel well. Do not stop taking ivacaftor without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking ivacaftor,

  • tell your doctor and pharmacist if you are allergic to ivacaftor, any other medications, or any of the ingredients in ivacaftor tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, you are taking or plan to take. Be sure to mention any of the following: certain antibiotics such as clarithromycin (Biaxin, in PrevPac), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), and telithromycin (Ketek); certain antifungals such as fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); certain medications for seizures such as carbamazepine (Carbatrol, Epitol, Tegretol, others), phenobarbital, and phenytoin (Dilantin, Phenytek); midazolam; rifabutin (Mycobutin); rifampin (Rifadin, in Rifamate, in Rifater, Rimactane); tacrolimus (Astagraf, Prograf), or warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with ivacaftor, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have or have ever had liver or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking ivacaftor, call your doctor.

  • you should know that ivacaftor may make you dizzy. Do not drive a car or operate machinery until you know how this medication affects you.

Do not eat grapefruit or Seville oranges or drink grapefruit juice while taking this medication.

If you remember the missed dose within 6 hours of the time you were scheduled to take it, take the missed dose right away with a fat-containing food. However, if more than 6 hours have passed since the scheduled time, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Ivacaftor may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • rash

    • joint pain

    • mouth and throat pain

    • fever, sore throat, runny nose, or other signs of infection

    • diarrhea

    • dizziness

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • nausea

    • vomiting

    • loss of appetite

    • pain in the upper right part of the stomach

    • dark urine

    • extreme tiredness

    • unusual bleeding or bruising

    • yellowing of the skin or eyes

    • vision changes

  • Ivacaftor may increase the risk that you or your child may develop cataracts. Talk to your doctor or your child's doctor about the risks of taking this medication.

  • Ivacaftor may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • dizziness

  • diarrhea

Keep all appointments with your doctor and the laboratory. Your doctor will order an eye exam and certain lab tests before and during your treatment to check your body's response to ivacaftor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The metabolism of Ivacaftor can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Ivacaftor can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Ivacaftor.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Ivacaftor.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Ivacaftor.
Clopidogrel Clopidogrel The metabolism of Ivacaftor can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Erythromycin can be decreased when combined with Ivacaftor.
Fenofibrate Fenofibrate The metabolism of Ivacaftor can be decreased when combined with Fenofibrate.
Paregoric Paregoric The serum concentration of Morphine can be increased when it is combined with Ivacaftor.
Reserpine Reserpine The metabolism of Ivacaftor can be increased when combined with Reserpine.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Ivacaftor.
Triamcinolone Triamcinolone The metabolism of Ivacaftor can be increased when combined with Triamcinolone.
Fluconazole Injection Fluconazole Injection The metabolism of Ivacaftor can be decreased when combined with Fluconazole.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be decreased when combined with Ivacaftor.
Metronidazole Injection Metronidazole Injection The metabolism of Ivacaftor can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The serum concentration of Morphine can be increased when it is combined with Ivacaftor.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Ivacaftor.
Ondansetron Ondansetron The metabolism of Ivacaftor can be decreased when combined with Ondansetron.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Ivacaftor.
Oxcarbazepine Oxcarbazepine The metabolism of Ivacaftor can be increased when combined with Oxcarbazepine.
Zaleplon Zaleplon The metabolism of Ivacaftor can be decreased when combined with Zaleplon.
Anakinra Anakinra The metabolism of Ivacaftor can be increased when combined with Anakinra.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Ivacaftor.
Etanercept Injection Etanercept Injection The metabolism of Ivacaftor can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Ivacaftor can be increased when combined with Modafinil.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Ivacaftor.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Ivacaftor.
Dutasteride Dutasteride The metabolism of Ivacaftor can be decreased when combined with Dutasteride.
Eplerenone Eplerenone The metabolism of Ivacaftor can be decreased when combined with Eplerenone.
Zonisamide Zonisamide The metabolism of Ivacaftor can be decreased when combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Ivacaftor can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Ivacaftor.
Atazanavir Atazanavir The metabolism of Ivacaftor can be decreased when combined with Atazanavir.
Rosuvastatin Rosuvastatin The metabolism of Ivacaftor can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Ivacaftor.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Ivacaftor.
Aprepitant Aprepitant The metabolism of Aprepitant can be decreased when combined with Ivacaftor.
Tegaserod Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Ivacaftor.
Tadalafil Tadalafil The metabolism of Ivacaftor can be decreased when combined with Tadalafil.
Progesterone Progesterone The metabolism of Ivacaftor can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Ivacaftor can be decreased when combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Ivacaftor can be increased when combined with Infliximab.
Rifaximin Rifaximin The serum concentration of Ivacaftor can be decreased when it is combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Ivacaftor can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Ivacaftor can be decreased when combined with Norethisterone.
Erlotinib Erlotinib The metabolism of Ivacaftor can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Ivacaftor.
Voriconazole Voriconazole The metabolism of Ivacaftor can be decreased when combined with Voriconazole.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Ivacaftor.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Ivacaftor.
Ranolazine Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Ivacaftor.
Abatacept Injection Abatacept Injection The metabolism of Ivacaftor can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Ivacaftor can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Ivacaftor.
Gefitinib Gefitinib The metabolism of Ivacaftor can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The serum concentration of Paliperidone can be increased when it is combined with Ivacaftor.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Ivacaftor.
Posaconazole Posaconazole The metabolism of Ivacaftor can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Ivacaftor can be decreased when combined with Primaquine.
Darunavir Darunavir The metabolism of Darunavir can be decreased when combined with Ivacaftor.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Ivacaftor.
Sorafenib Sorafenib The metabolism of Ivacaftor can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Ivacaftor can be decreased when combined with Sunitinib.
Lapatinib Lapatinib The metabolism of Ivacaftor can be decreased when combined with Lapatinib.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Ivacaftor.
Armodafinil Armodafinil The metabolism of Ivacaftor can be increased when combined with Armodafinil.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Ivacaftor.
Nilotinib Nilotinib The metabolism of Ivacaftor can be decreased when combined with Nilotinib.
Toremifene Toremifene The serum concentration of Toremifene can be increased when it is combined with Ivacaftor.
Budesonide Budesonide The metabolism of Ivacaftor can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Ivacaftor can be decreased when combined with Chloramphenicol.
Desvenlafaxine Desvenlafaxine The metabolism of Ivacaftor can be decreased when combined with Desvenlafaxine.
Tretinoin Tretinoin The metabolism of Ivacaftor can be decreased when combined with Tretinoin.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Ivacaftor.
Certolizumab Injection Certolizumab Injection The metabolism of Ivacaftor can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Ivacaftor.
Irinotecan Injection Irinotecan Injection The metabolism of Ivacaftor can be decreased when combined with Irinotecan.
Praziquantel Praziquantel The metabolism of Ivacaftor can be decreased when combined with Praziquantel.
Mitotane Mitotane The serum concentration of Ivacaftor can be decreased when it is combined with Mitotane.
Rufinamide Rufinamide The metabolism of Rufinamide can be decreased when combined with Ivacaftor.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Ivacaftor.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Ivacaftor.
Milnacipran Milnacipran The metabolism of Ivacaftor can be decreased when combined with Milnacipran.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Ivacaftor.
Lacosamide Lacosamide The metabolism of Ivacaftor can be decreased when combined with Lacosamide.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Ivacaftor.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Ivacaftor.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Ivacaftor.
Saxagliptin Saxagliptin The metabolism of Ivacaftor can be decreased when combined with Saxagliptin.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Ivacaftor.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Ivacaftor.
Golimumab Injection Golimumab Injection The metabolism of Ivacaftor can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Ivacaftor.
Albendazole Albendazole The metabolism of Ivacaftor can be decreased when combined with Albendazole.
Levonorgestrel Levonorgestrel The metabolism of Ivacaftor can be decreased when combined with Levonorgestrel.
Tocilizumab Injection Tocilizumab Injection The metabolism of Ivacaftor can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Cabazitaxel can be increased when it is combined with Ivacaftor.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Ivacaftor.
Roflumilast Roflumilast The metabolism of Ivacaftor can be decreased when combined with Roflumilast.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Ivacaftor.
Telaprevir Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Ivacaftor.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Ivacaftor can be decreased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Ivacaftor.
Ticagrelor Ticagrelor The serum concentration of Ticagrelor can be increased when it is combined with Ivacaftor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Ivacaftor.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Ivacaftor.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Ivacaftor.
Clobazam Clobazam The serum concentration of Clobazam can be increased when it is combined with Ivacaftor.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be decreased when combined with Ivacaftor.
Axitinib Axitinib The metabolism of Ivacaftor can be decreased when combined with Axitinib.
Crizotinib Crizotinib The metabolism of Crizotinib can be decreased when combined with Ivacaftor.
Cabergoline Cabergoline The metabolism of Cabergoline can be decreased when combined with Ivacaftor.
Naloxone Injection Naloxone Injection The metabolism of Ivacaftor can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Ivacaftor.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Ivacaftor.
Enzalutamide Enzalutamide The serum concentration of Ivacaftor can be decreased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Ivacaftor.
Regorafenib Regorafenib The serum concentration of Regorafenib can be increased when it is combined with Ivacaftor.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Ivacaftor.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Ivacaftor.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Ivacaftor.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Ivacaftor.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Ivacaftor.
Apixaban Apixaban The serum concentration of Apixaban can be increased when it is combined with Ivacaftor.
Canagliflozin Canagliflozin The serum concentration of Canagliflozin can be increased when it is combined with Ivacaftor.
Dabrafenib Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Ivacaftor.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Ivacaftor.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Ivacaftor.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Ivacaftor.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Ivacaftor.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Ivacaftor.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Ivacaftor.
Simeprevir Simeprevir The metabolism of Simeprevir can be decreased when combined with Ivacaftor.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Ivacaftor.
Apremilast Apremilast The metabolism of Ivacaftor can be increased when combined with Apremilast.
Ceritinib Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Ivacaftor.
Siltuximab Injection Siltuximab Injection The metabolism of Ivacaftor can be increased when combined with Siltuximab.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Ivacaftor.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Ivacaftor.
Testosterone Injection Testosterone Injection The metabolism of Ivacaftor can be decreased when combined with Testosterone.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Ivacaftor.
Suvorexant Suvorexant The metabolism of Suvorexant can be decreased when combined with Ivacaftor.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Ivacaftor.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Ivacaftor.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Ivacaftor.
Nintedanib Nintedanib The serum concentration of Nintedanib can be increased when it is combined with Ivacaftor.
Secukinumab Injection Secukinumab Injection The metabolism of Ivacaftor can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Ivacaftor can be decreased when combined with Risperidone.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Ivacaftor.
Lenvatinib Lenvatinib The serum concentration of Lenvatinib can be increased when it is combined with Ivacaftor.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Ivacaftor.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Ivacaftor.
Haloperidol Injection Haloperidol Injection The metabolism of Haloperidol can be decreased when combined with Ivacaftor.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Ivacaftor can be decreased when combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Ivacaftor.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Ivacaftor.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ivacaftor can be decreased when combined with Ziprasidone.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Ivacaftor.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Ivacaftor.
Osimertinib Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Ivacaftor.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Ivacaftor.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Ivacaftor.
Dexamethasone Injection Dexamethasone Injection The serum concentration of Ivacaftor can be decreased when it is combined with Dexamethasone.
Venetoclax Venetoclax The metabolism of Venetoclax can be decreased when combined with Ivacaftor.
Cobicistat Cobicistat The metabolism of Ivacaftor can be decreased when combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Ivacaftor.
Rucaparib Rucaparib The serum concentration of Rucaparib can be increased when it is combined with Ivacaftor.
Ribociclib Ribociclib The metabolism of Ivacaftor can be decreased when combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Ivacaftor.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Ivacaftor.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Ivacaftor.
Deflazacort Deflazacort The metabolism of Ivacaftor can be increased when combined with Deflazacort.
Safinamide Safinamide The metabolism of Ivacaftor can be decreased when combined with Safinamide.
Midostaurin Midostaurin The serum concentration of Ivacaftor can be decreased when it is combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Ivacaftor.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Ivacaftor.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Ivacaftor.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be decreased when combined with Ivacaftor.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Ivacaftor.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Ivacaftor.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Ivacaftor.
Acalabrutinib Acalabrutinib The metabolism of Ivacaftor can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Ivacaftor can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Ivacaftor.
Buprenorphine Injection Buprenorphine Injection The metabolism of Ivacaftor can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The serum concentration of Ivacaftor can be decreased when it is combined with Apalutamide.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Ivacaftor.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Ivacaftor.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Ivacaftor.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Ivacaftor.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Ivacaftor.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Ivacaftor.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Ivacaftor.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Ivacaftor.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Ivacaftor.
Dacomitinib Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Ivacaftor.
Duvelisib Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Ivacaftor.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Ivacaftor.
Stiripentol Stiripentol The metabolism of Ivacaftor can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Ivacaftor.
Gilteritinib Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Ivacaftor.
Glasdegib Glasdegib The serum concentration of Glasdegib can be increased when it is combined with Ivacaftor.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Ivacaftor.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Ivacaftor.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Ivacaftor.
Rifamycin Rifamycin The serum concentration of Ivacaftor can be decreased when it is combined with Rifamycin.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Ivacaftor.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Ivacaftor can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Ivacaftor.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Ivacaftor.
Alpelisib Alpelisib The metabolism of Alpelisib can be decreased when combined with Ivacaftor.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Ivacaftor.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Ivacaftor.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Ivacaftor.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Ivacaftor.
Pitolisant Pitolisant The serum concentration of Ivacaftor can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Ivacaftor.
Lefamulin Lefamulin Ivacaftor may decrease the excretion rate of Lefamulin which could result in a higher serum level.
Phenytoin Injection Phenytoin Injection The serum concentration of Ivacaftor can be decreased when it is combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Ivacaftor can be decreased when it is combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Ivacaftor.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Ivacaftor.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Ivacaftor.
Lasmiditan Lasmiditan The serum concentration of Lasmiditan can be increased when it is combined with Ivacaftor.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Ivacaftor.
Tazemetostat Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Ivacaftor.
Cenobamate Cenobamate The serum concentration of Ivacaftor can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Ivacaftor.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Ivacaftor.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Ivacaftor.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Ivacaftor.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Ivacaftor.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Ivacaftor.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Ivacaftor.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Ivacaftor.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Ivacaftor.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Ivacaftor can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Ivacaftor.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Ivacaftor.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Ivacaftor.
Trazodone Trazodone The metabolism of Ivacaftor can be decreased when combined with Trazodone.
Phenobarbital Phenobarbital The serum concentration of Ivacaftor can be decreased when it is combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Ivacaftor.
Primidone Primidone The serum concentration of Ivacaftor can be decreased when it is combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Ivacaftor.
Diazepam Diazepam The metabolism of Ivacaftor can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Ivacaftor can be decreased when combined with Lorazepam.
Phenelzine Phenelzine The metabolism of Ivacaftor can be decreased when combined with Phenelzine.
Prochlorperazine Prochlorperazine The metabolism of Ivacaftor can be decreased when combined with Prochlorperazine.
Dapsone Dapsone The metabolism of Ivacaftor can be decreased when combined with Dapsone.
Oxycodone Oxycodone The metabolism of Ivacaftor can be decreased when combined with Oxycodone.
Methadone Methadone The metabolism of Ivacaftor can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Ivacaftor can be decreased when combined with Oxybutynin.
Phentermine Phentermine The metabolism of Ivacaftor can be decreased when combined with Phentermine.
Hydrocortisone Hydrocortisone The metabolism of Ivacaftor can be decreased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Ivacaftor.
Dactinomycin Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Ivacaftor.
Carbamazepine Carbamazepine The serum concentration of Ivacaftor can be decreased when it is combined with Carbamazepine.
Clonidine Clonidine The metabolism of Ivacaftor can be decreased when combined with Clonidine.
Cimetidine Cimetidine The metabolism of Ivacaftor can be decreased when combined with Cimetidine.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Ivacaftor.
Loperamide Loperamide The metabolism of Ivacaftor can be decreased when combined with Loperamide.
Daunorubicin Daunorubicin The metabolism of Ivacaftor can be increased when combined with Daunorubicin.
Digoxin Digoxin Ivacaftor may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine The metabolism of Ivacaftor can be decreased when combined with Chloroquine.
Quinine Quinine The serum concentration of Quinine can be increased when it is combined with Ivacaftor.
Clindamycin Injection Clindamycin Injection The metabolism of Ivacaftor can be decreased when combined with Clindamycin.
Amitriptyline Amitriptyline The metabolism of Ivacaftor can be decreased when combined with Amitriptyline.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Ivacaftor.
Quinidine Quinidine The serum concentration of Quinidine can be increased when it is combined with Ivacaftor.
Isoniazid Isoniazid The metabolism of Ivacaftor can be decreased when combined with Isoniazid.
Rifampin Rifampin The serum concentration of Ivacaftor can be decreased when it is combined with Rifampicin.
Tamoxifen Tamoxifen The metabolism of Ivacaftor can be decreased when combined with Tamoxifen.
Methimazole Methimazole The metabolism of Ivacaftor can be decreased when combined with Methimazole.
Dextromethorphan Dextromethorphan The metabolism of Ivacaftor can be decreased when combined with Dextromethorphan.
Chlorpheniramine Chlorpheniramine The metabolism of Ivacaftor can be decreased when combined with Chlorpheniramine.
Danazol Danazol The metabolism of Ivacaftor can be decreased when combined with Danazol.
Disulfiram Disulfiram The metabolism of Ivacaftor can be decreased when combined with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Ivacaftor can be decreased when combined with Propranolol.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Ivacaftor.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Ivacaftor.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Ivacaftor.
Cephalexin Cephalexin The metabolism of Ivacaftor can be decreased when combined with Cephalexin.
Ketoconazole Ketoconazole The metabolism of Ivacaftor can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Ivacaftor.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Ivacaftor.
Vinblastine Vinblastine The metabolism of Vinblastine can be decreased when combined with Ivacaftor.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Ivacaftor.
Hydroxyzine Hydroxyzine The metabolism of Ivacaftor can be decreased when combined with Hydroxyzine.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Ivacaftor.
Triazolam Triazolam The metabolism of Ivacaftor can be decreased when combined with Triazolam.
Diltiazem Diltiazem The metabolism of Ivacaftor can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Ivacaftor can be decreased when combined with Nifedipine.
Verapamil Verapamil The metabolism of Ivacaftor can be decreased when combined with Verapamil.
Etoposide Etoposide The serum concentration of Etoposide can be increased when it is combined with Ivacaftor.
Glyburide Glyburide The metabolism of Ivacaftor can be decreased when combined with Glyburide.
Pentamidine Injection Pentamidine Injection The metabolism of Ivacaftor can be decreased when combined with Pentamidine.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Ivacaftor.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Ivacaftor.
Buspirone Buspirone The metabolism of Ivacaftor can be decreased when combined with Buspirone.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Ivacaftor.
Ciprofloxacin Ciprofloxacin The metabolism of Ciprofloxacin can be decreased when combined with Ivacaftor.
Clozapine Clozapine The metabolism of Clozapine can be decreased when combined with Ivacaftor.
Clarithromycin Clarithromycin The metabolism of Ivacaftor can be decreased when combined with Clarithromycin.
Felodipine Felodipine The metabolism of Ivacaftor can be decreased when combined with Felodipine.
Pravastatin Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Ivacaftor.
Simvastatin Simvastatin The serum concentration of Ivacaftor can be increased when it is combined with Simvastatin.
Teniposide Injection Teniposide Injection The metabolism of Ivacaftor can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Ivacaftor can be decreased when combined with Itraconazole.
Bisoprolol Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Ivacaftor.
Doxazosin Doxazosin The metabolism of Ivacaftor can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Ivacaftor can be decreased when combined with Isradipine.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Ivacaftor.
Fluvastatin Fluvastatin The metabolism of Ivacaftor can be decreased when combined with Fluvastatin.
Famciclovir Famciclovir The metabolism of Ivacaftor can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Ivacaftor can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Ivacaftor can be decreased when combined with Nefazodone.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Ivacaftor.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Ivacaftor.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ivacaftor can be decreased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Nicardipine can be decreased when combined with Ivacaftor.
Ticlopidine Ticlopidine The metabolism of Ivacaftor can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Ivacaftor.
Nisoldipine Nisoldipine The metabolism of Ivacaftor can be decreased when combined with Nisoldipine.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Ivacaftor.
Indinavir Indinavir The metabolism of Ivacaftor can be decreased when combined with Indinavir.
Ritonavir Ritonavir The metabolism of Ivacaftor can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Ivacaftor can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Ivacaftor.
Zafirlukast Zafirlukast The metabolism of Ivacaftor can be decreased when combined with Zafirlukast.
Nelfinavir Nelfinavir The metabolism of Nelfinavir can be decreased when combined with Ivacaftor.
Fexofenadine Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Ivacaftor.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Ivacaftor.
Flutamide Flutamide The metabolism of Ivacaftor can be decreased when combined with Flutamide.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be decreased when combined with Ivacaftor.
Finasteride Finasteride The metabolism of Ivacaftor can be decreased when combined with Finasteride.
Quetiapine Quetiapine The metabolism of Ivacaftor can be decreased when combined with Quetiapine.
Efavirenz Efavirenz The metabolism of Ivacaftor can be decreased when combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Ivacaftor can be increased when it is combined with Sildenafil.
Thalidomide Thalidomide The metabolism of Ivacaftor can be increased when combined with Thalidomide.
Nateglinide Nateglinide The metabolism of Ivacaftor can be decreased when combined with Nateglinide.

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