Home › NDC Lookup › RxCUI directory › RxCUI 2166399

Ivacaftor 25 MG Oral Granules — RxCUI 2166399

RxNorm drug concept · Semantic clinical drug
RxCUI 2166399 Semantic clinical drug · SCD ● Current RxNorm concept 6 FDA products 7 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI2166399
Official nameIvacaftor 25 MG Oral Granules
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
FDA products mapped6
Package NDCs mapped7
Reported Medicaid activity (SDUD)1,404 prescriptions · 14 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Ivacaftor: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • Kalydeco doesn't cure cystic fibrosis, but it targets the root cause in people with certain gene mutations. It helps a faulty protein in your cells — called CFTR — work better by k...
  • What exactly does Kalydeco do for cystic fibrosis — does it cure it?
  • It really does matter what you take it with. Fat in food increases how much ivacaftor your body absorbs — by as much as 2.5 to 4 times. Taking it with just water means you're likel...
  • Why does it have to be taken with food? Can I just take it with water?
📖 Read our full Ivacaftor guide →

🕸️ Concept Web — How Ivacaftor 25 MG Oral Granules Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Ivacaftor 25 MG Oral Granules RxCUI 2166399

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 1

    The active substance itself — no strength, form, or brand attached yet.

    • Ivacaftor 1243041
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Kalydeco 1243047
  3. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Ivacaftor Oral Granules 1606861
    • Ivacaftor Granule Product 1606860
    • Ivacaftor Oral Product 1243043
    • Ivacaftor Oral Granules [Kalydeco] 1606864
    • Kalydeco Granule Product 1606865
    • Kalydeco Oral Product 1243050
    • Oral Granules 317690
    • Granule Product 1294708
    • +1 more in this family
  4. Clinical & branded drugs 3

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 13 of 14 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Ivacaftor 25 MG SCDC · 2166398
  • Ivacaftor Oral Granules SCDF · 1606861
  • Ivacaftor Granule Product SCDG · 1606860
  • Ivacaftor Oral Product SCDG · 1243043

Brand-Name Concepts

  • Ivacaftor 25 MG Oral Granules [Kalydeco] SBD · 2166401
  • Ivacaftor 25 MG [Kalydeco] SBDC · 2166400
  • Ivacaftor Oral Granules [Kalydeco] SBDF · 1606864
  • Kalydeco Granule Product SBDG · 1606865
  • Kalydeco Oral Product SBDG · 1243050
  • Kalydeco BN · 1243047

📦 FDA Products & Package NDCs

6 products · 7 package NDCs
7 package NDCs map to RxCUI 2166399 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
51167-0200-01 4 BLISTER PACK in 1 CARTON (51167-200-01) / 14 TABLET, FILM... Kalydeco Vertex Pharmaceuticals Incorporated 2012-01-31
51167-0200-02 1 BOTTLE in 1 CARTON (51167-200-02) / 60 TABLET, FILM COATE... Kalydeco Vertex Pharmaceuticals Incorporated 2012-01-31
51167-0300-01 56 GRANULE in 1 CARTON (51167-300-01) Kalydeco Vertex Pharmaceuticals Incorporated 2015-03-23
51167-0400-01 56 GRANULE in 1 CARTON (51167-400-01) Kalydeco Vertex Pharmaceuticals Incorporated 2015-03-23
51167-0600-01 56 GRANULE in 1 CARTON (51167-600-01) Kalydeco Vertex Pharmaceuticals Incorporated 2019-04-29
51167-0770-01 56 GRANULE in 1 CARTON (51167-770-01) Kalydeco Vertex Pharmaceuticals Incorporated 2023-05-03
51167-0785-01 56 GRANULE in 1 CARTON (51167-785-01) Kalydeco Vertex Pharmaceuticals Incorporated 2023-05-03
Observed labelers: Vertex Pharmaceuticals Incorporated (7) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.