Medication interaction hub

What Supplements Interact with Tadalafil?

Tadalafil brand names: Cialis, Tadliq. Every interaction below applies to the brands too.

144 Interactions 5 Major 98 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Tadalafil? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Tadalafil against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Grapefruit juice is the first thing to know about if you take tadalafil (Cialis, Tadliq). It blocks CYP3A4, the enzyme that clears the drug, so blood levels climb and side effects like a steep drop in blood pressure become more likely. That same enzyme pathway runs through most of this list, 121 of the 144 ingredients on file touch it one way or another, and with five entries rated major, supplements deserve genuine care alongside this medication.

Beyond the enzyme story, hawthorn and heavy drinking can stack with tadalafil's blood-pressure-lowering effect, sometimes to the point of dizziness or fainting, while St. John's wort pushes the other way and can quietly drain the drug of its benefit. A few entries can also block an oral dose from absorbing. Ninety-eight interactions rate moderate and 41 minor, but the five major ones, grapefruit included, are where to focus first.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 98 Minor 41 No known interaction 1,308

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Tadalafil: Top Interactions at a Glance

The Tadalafil supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 144 interacting ingredients — plus 1,308 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Tadalafil Combinations Today

The Tadalafil + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Ashwagandha + Tadalafili

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible Vitamin D + Tadalafili

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Beet + Tadalafili

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Ginger + Tadalafili

Ginger might increase or decrease the levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible L-citrulline + Tadalafili

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.

Read the full interaction Minor Likelihood Unlikely Green Tea + Tadalafili

Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Tadalafil

All 1,452 ingredients in our database, ranked by severity — 144 with a Tadalafil interaction on file and 1,308 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Tadalafil?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ashwagandha with Tadalafil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Full Ashwagandha + Tadalafil answer

Can you take Vitamin D with Tadalafil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Tadalafil answer

Can you take Beet with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Tadalafil answer

Can you take Ginger with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Tadalafil answer

Can you take L-citrulline with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.

Full L-citrulline + Tadalafil answer

Can you take Lentinan with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Laboratory research suggests that lentinan might increase the activity of cytochrome P450 3A4 (CYP3A4).

Full Lentinan + Tadalafil answer

Can you take Licorice with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.

Full Licorice + Tadalafil answer

Can you take Lime with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.

Full Lime + Tadalafil answer

Can you take Methoxylated Flavones with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that methoxylated flavones might inhibit cytochrome P450 3A4 (CYP3A4).

Full Methoxylated Flavones + Tadalafil answer

Can you take Moringa with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Full Moringa + Tadalafil answer

Can you take Neem with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.

Full Neem + Tadalafil answer

Can you take Oregon Grape with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.

Full Oregon Grape + Tadalafil answer

Can you take Padang Cassia with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that a methanol extract of Padang cassia inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full Padang Cassia + Tadalafil answer

Can you take Panax Ginseng with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng might increase or decrease levels of drugs metabolized by CYP3A4.

Full Panax Ginseng + Tadalafil answer

Can you take Peony with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Peony + Tadalafil answer

Can you take Peppermint with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Full Peppermint + Tadalafil answer

Can you take Phellodendron with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.

Full Phellodendron + Tadalafil answer

Can you take Propolis with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.

Full Propolis + Tadalafil answer

Can you take Quercetin with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of CYP3A4 substrates.

Full Quercetin + Tadalafil answer

Can you take Rabdosia Rubescens with Tadalafil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Tadalafil answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Tadalafil is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Tadalafil, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Tadalafil sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Tadalafil through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Tadalafil through this category.

Phosphodiesterase-5 Inhibitors 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Tadalafil through this category.

Vasodilators 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Tadalafil through this category.

Tadalafil (Cialis) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Tadalafil through this category.

About Tadalafil

A phosphodiesterase inhibitor used to treat erectile dysfunction, enlarged prostate symptoms, and pulmonary arterial hypertension.

Generic name: Tadalafil  ·  Brand names: Cialis, Tadliq.

See the full Tadalafil drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Tadalafil

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Tadalafil.

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Pharmacist Counseling Corner

Tadalafil & Supplements: Common Questions

What supplements interact with Tadalafil?
Our database currently documents 144 ingredients with a known Tadalafil interaction (5 major, 98 moderate, 41 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 144. The highest-ranked right now: Grapefruit, Activated Charcoal, American Mistletoe.
Which Tadalafil supplement interactions are the most serious?
The 5 major-rated combinations — led by Grapefruit, Activated Charcoal, American Mistletoe, Hawthorn and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Tadalafil?
Plenty of supplements coexist fine with Tadalafil; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Cialis have the same supplement interactions as Tadalafil?
Yes — Cialis, Tadliq all contain Tadalafil, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Tadalafil and my other medications?
This page covers Tadalafil against supplements and herbal ingredients. Checking Tadalafil against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Tadalafil drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.