Drug & supplement interaction

Butea Superba + Tadalafil

Tadalafil brand names: Cialis, Tadliq.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Butea Superba has a moderate interaction with Tadalafil. Butea superba is thought to inhibit phosphodiesterase and cause vasodilation.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Butea Superba and Tadalafil

Here is the interaction we found between these two, with the evidence behind it.

Moderate

PHOSPHODIESTERASE-5 INHIBITORS

Why this applies to Tadalafil

Tadalafil falls under PHOSPHODIESTERASE-5 INHIBITORS — the group Butea Superba interacts with.

Butea superba is thought to inhibit phosphodiesterase and cause vasodilation. Theoretically, concurrent use of phosphodiesterase-5 inhibitors and Butea superba might result in additive vasodilation and hypotension. Phosphodiesterase-5 inhibitors include sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra).
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with Butea superba and tadalafil (Cialis). Tadalafil already works by relaxing and widening blood vessels, which is how it helps with erections, an enlarged prostate, or lung blood pressure. Lab work suggests Butea superba may act in a similar way and could mildly relax blood vessels too. So in theory, taking the two together could stack those effects and push your blood pressure too low.

If that happened, you might feel dizzy, lightheaded, flushed, or get a headache, especially when standing up quickly. I want to be honest though: this is a theoretical concern based on how the herb behaves in the lab, not strong human studies. Still, since the safety of Butea superba isn't well understood, please check with your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Cherdshewasart W, Nimsakul N. Clinical trial of Butea superba, an alternative herbal treatment for erectile dysfunction. Asian J Androl 2003;5:243-6.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Butea Superba Also Interacts With Other Medications

Butea Superba has 6 moderate known drug interactions in our database — the Tadalafil one above is one of them. If you take anything else, check it against the full list below.

Moderate 6 No known interaction 2,824 (incl. Tadalafil)
Taking anything else?

Check Another of Your Medications Against Butea Superba

Covers the 2,830 medications we’ve checked against Butea Superba. Pick one to open its full report.

From our Q&A

Questions About Butea Superba or Tadalafil

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Butea Superba or Tadalafil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tadalafil

This page covers Butea Superba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tadalafil page lists 144 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Mistletoe (major), Grapefruit (major), Hawthorn (major) and St. John's Wort (major).

By severity: 5 major · 98 moderate · 41 minor.

From our pharmacist’s overview on the Tadalafil page

“Grapefruit juice is the first thing to know about if you take tadalafil (Cialis, Tadliq). It blocks CYP3A4, the enzyme that clears the drug, so blood levels climb and side effects like a steep drop in blood pressure become more likely.”

Reviewed by 2 · Jul 18, 2026

Open the Tadalafil interaction page

One more smart check

Taking Butea Superba as Part of a Dietary Supplement Product? Check It for Interactions

We hold 23 real supplement products containing Butea Superba, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Butea Superba. Your product may carry other ingredients that interact with Tadalafil too, on top of Butea Superba — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Butea Superba and Tadalafil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Butea Superba
Steady interest

#1,190 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tadalafil
Top 1%

#16 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Butea Superba

What is Butea Superba?

Butea Superba
  • Erectile dysfunction
  • Low libido
  • Male sexual performance
  • General vitality and energy
  • Traditional tonic

Butea superba is a Thai herb traditionally used to support male sexual health, but the human evidence is very limited and mostly small or low-quality. Its safety has not been well studied, so caution is advised, and you should talk with a pharmacist or doctor before trying it—especially if you have a medical condition or take other medicines.

Read the full Butea Superba monograph & all interactions
Medication

About Tadalafil

What Is Tadalafil Used For?

Brand names: Cialis, Tadliq

Tadalafil tablets (including Cialis and generic tadalafil) are used to treat erectile dysfunction (ED), the symptoms of benign prostatic hyperplasia (BPH — an enlarged prostate), or both conditions together. When used with the drug finasteride to start BPH treatment, this combination is recommended for up to 26 weeks.

Adcirca, Alyq (tablets), and Tadliq (oral suspension) are indicated specifically for pulmonary arterial hypertension (PAH — high blood pressure in the lungs), to improve the ability to exercise.

See full Tadalafil drug information
Keep checking

Other Drugs & Butea Superba

Browse every other medication we’ve checked against Butea Superba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
6Moderate
0Minor
2,823No known interaction
6 Moderate 2,823 No interaction
Moderate

6 interactions

No interaction 2,823 drugs checked — show the list

We also checked Butea Superba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,823 medications checked with no known interaction — see the full Butea Superba list.

See the full Butea Superba interactions page
See every supplement checked against Tadalafil, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Butea Superba monograph › Uses, safety, and every drug interaction in one place Tadalafil supplement interactions › Every supplement checked against Tadalafil, ranked by severity Tadalafil drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Butea Superba and Tadalafil Together: Common Questions

Can you take Butea Superba with Tadalafil?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Butea Superba and Tadalafil interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Tadalafil and Butea Superba?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.