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Methoxylated Flavones Drug Interactions, Uses, Safety & More

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Methoxylated Flavones Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated August 2026

Based on the available evidence, the overall risk of a clinically significant Methoxylated Flavones drug interaction appears low for most people, because every listed interaction is theoretical and none has been confirmed in humans. All of the interactions are rated moderate rather than major, and each one rests on lab research alone, with no human reports so far.

Interactions deserving the most attention

The combination most worth watching is with anticoagulant or antiplatelet drugs such as aspirin, clopidogrel, or ibuprofen, since lab studies suggest methoxylated flavones may add to their blood-thinning effects and raise bleeding risk. Lab findings also hint these compounds could raise blood levels of narrow-margin medicines moved by a transporter protein, including certain chemotherapy drugs. Neither effect has been documented in people, but these medicines leave the least room for error, so they deserve the closest attention.

What the rest of the list means

Although hundreds of medications appear on the interaction list, that number reflects a handful of predicted mechanisms, mainly possible effects on enzymes and transporters the body uses to process drugs. These predictions come from test-tube research, some of it conflicting, and so far none has been shown to cause meaningful changes in people. A long list here signals caution to study further, not proven harm.

Check your medications against Methoxylated Flavones

Based on HelloPharmacist’s Methoxylated Flavones interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Methoxylated Flavones

893 medications have a known interaction with Methoxylated Flavones, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
Ado-trastuzumab EmtansineKadcyla› AbciximabReoPro› AbemaciclibVerzenio› Abiraterone› Abiraterone AcetateYonsa, Zytiga› AbrocitinibCibinqo› AcalabrutinibCalquence› AcenocoumarolSintrom› AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength› Acetaminophen, AspirinGemnisyn› Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine› Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu› Acetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more› Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more› Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine› Acetaminophen, Butalbital, CodeineBancap w/ Codeine› Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3› Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound› Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more› Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3› Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS› Acetaminophen, Caffeine, IsomethepteneMigralam› Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual› Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief› Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex› Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief› Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength› Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Methoxylated Flavones combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Methoxylated Flavones affects

Every type of medication (drug category) Methoxylated Flavones is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 5 drug categories Methoxylated Flavones interacts with
Anticoagulant/antiplatelet DrugsCytochrome P450 1a2 (cyp1a2) SubstratesCytochrome P450 3a4 (cyp3a4) SubstratesOrganic Anion-transporting Polypeptide Substrates (oatp)P-glycoprotein Substrates
Anticoagulant/Antiplatelet Drugs

In vitro evidence suggests that some methoxylated flavones have antiplatelet effects. Theoretically, methoxylated flavones might additive effects when used with anticoagulant or antiplatelet drugs.
Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Some in vitro evidence suggests that methoxylated flavones might induce CYP1A2, possibly by increasing gene transcription. However, other in vitro research has not shown this effect. So far this interaction has not been reported in humans. Theoretically, concurrent use of methoxylated flavones and drugs metabolized by CYP1A2 might increase drug metabolism, decrease serum levels, and reduce effectiveness.
Some drugs metabolized by CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), Pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline (Slo-bid, Theo-Dur, others), zileuton (Zyflo), Zolmitriptan (Zomig), and others.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

In vitro evidence suggests that methoxylated flavones might inhibit cytochrome P450 3A4 (CYP3A4). This effect seems to be structure-dependent, and does not occur with all methoxylated flavones. So far this interaction has not been reported in humans. Theoretically, concurrent use of certain methoxylated flavones with drugs metabolized by CYP3A4 might result in increased drug levels and an increased risk for adverse effects.
Some drugs metabolized by CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), Pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline (Slo-bid, Theo-Dur, others), zileuton (Zyflo), Zolmitriptan (Zomig), and others.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

In vitro, methoxylated flavones inhibit organic anion transporting polypeptide (OATP) 1B1, 1B3, and 2B1. This may reduce the bioavailability of oral drugs that are substrates of OATP. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

In vitro evidence shows that some methoxylated flavones including tangeretin, nobiletin, and heptamethoxyflavone, inhibit P-glycoprotein. Theoretically, these methoxylated flavones might increase absorption and blood levels of drugs that are transported by P-glycoprotein.
Some of these drugs include some chemotherapeutic agents (daunorubicin, docetaxel, etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), protease inhibitors (amprenavir, indinavir, nelfinavir, saquinavir), H2 antagonists (cimetidine, ranitidine), some calcium channel blockers (diltiazem, verapamil), corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.

Likelihood Possible Evidence D
Monograph

Methoxylated Flavones: Uses, Safety & Side Effects

The bottom line

Methoxylated flavones (often called polymethoxyflavones) are a group of plant compounds, found mainly in citrus peel, that include substances like nobiletin and tangeretin. Lab and animal studies suggest possible antioxidant and anti-inflammatory effects, but solid human research is very limited, so their real-world benefits are unproven. Talk with a pharmacist or doctor before using them, especially if you take medicines or are pregnant or breastfeeding.

Part used
Plant-derived flavonoids (often from citrus peel and other plants)
Common forms
Capsules, tablets, powders, and combination flavonoid supplements
People commonly use it for
  • Antioxidant support
  • Circulation and blood vessel health
  • Anti-inflammatory support
  • Skin and aging support
  • General 'metabolism' or wellness blends

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally found in foods, but concentrated supplement safety in humans is not well studied.

PregnancyLikely Safe

When consumed orally in amounts typically found in foods. There is insufficient reliable information available about the safety of methoxylated flavon...

Read the full pregnancy detail
BreastfeedingLikely Safe

When consumed orally in amounts typically found in foods. There is insufficient reliable information available about the safety of methoxylated flavon...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Methoxylated flavones are a type of plant compound that belongs to the larger flavonoid family. They are sometimes called polymethoxyflavones (PMFs). Well-known examples include nobiletin and tangeretin. These compounds are found in especially high amounts in the peel of citrus fruits like oranges and tangerines, which is why supplements are often made from citrus peel extracts.

Because the peel of fruit is usually thrown away, companies have looked for ways to turn it into supplements and ingredients. Methoxylated flavones are sold on their own and as part of "flavonoid complex" or antioxidant blends. People take them hoping for antioxidant, anti-inflammatory, and circulation-related benefits.

Uses & effectiveness

People use methoxylated flavones for a wide range of reasons, including antioxidant support, healthy circulation, reducing inflammation, and general wellness. You may also see them marketed for skin health, metabolism, and "cellular" support.

It is important to be honest about the evidence: most of what we know comes from laboratory and animal studies. These early studies are interesting, but they do not prove that taking these compounds as a supplement will help people. There is very little high-quality human research, and we cannot say that methoxylated flavones treat, prevent, or cure any health condition. If you see strong health claims on a product label, treat them with caution.

How it works

In lab studies, methoxylated flavones such as nobiletin and tangeretin act as antioxidants, meaning they may help neutralize unstable molecules called free radicals. They have also shown anti-inflammatory activity in cell and animal models, where they appear to affect certain signaling pathways involved in inflammation.

Researchers have explored other possible effects in the lab as well, including influence on fat and sugar metabolism and on blood vessels. It is important to remember that these are mostly test-tube and animal findings. What happens in a dish or in a mouse does not always happen in the human body, especially since how much of these compounds the body actually absorbs and uses is still being studied.

Safety & precautions

Methoxylated flavones are found naturally in citrus foods, and eating citrus is considered safe for most people. However, the safety of taking concentrated supplement doses over time has not been well studied in humans.

People with existing medical conditions, those taking prescription medicines, and anyone scheduled for surgery should check with a pharmacist or doctor first. Because reliable safety data is lacking, people who are pregnant or breastfeeding should avoid concentrated supplements and stick to normal amounts found in food. Always buy from reputable brands, since supplements are not tightly regulated and quality can vary.

Side effects

There is not much human data on side effects from methoxylated flavone supplements. Based on other flavonoid products, possible side effects could include mild stomach upset, nausea, or headache, though this is not well documented for these specific compounds.

Serious side effects have not been clearly reported, but this likely reflects a lack of study rather than proof of safety. Stop using the product and seek medical care if you notice signs of an allergic reaction, such as rash, swelling, or trouble breathing.

Dosing

There is no established standard dose for methoxylated flavones. Products vary widely in how much they contain and what other ingredients they are combined with.

If you choose to use one, follow the directions on the product label and do not exceed the recommended amount. Because effective and safe doses have not been defined in good human studies, it is best to check with a pharmacist or doctor before starting, especially if you take other medicines or have a health condition.

Pregnancy & Breastfeeding

Methoxylated Flavones & Pregnancy

Likely Safe

When consumed orally in amounts typically found in foods. There is insufficient reliable information available about the safety of methoxylated flavones when used in amounts greater than those found in foods during pregnancy or breast-feeding; avoid using in amounts greater than those typically found in foods.

  1. Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52:673-751.

Methoxylated Flavones & Breastfeeding

Likely Safe

When consumed orally in amounts typically found in foods. There is insufficient reliable information available about the safety of methoxylated flavones when used in amounts greater than those found in foods during pregnancy or breast-feeding; avoid using in amounts greater than those typically found in foods.

  1. Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52:673-751.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 7 references that drive our Methoxylated Flavones monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52:673-751. DOI
  2. Robbins RC. Effect of methoxylated flavones on erythrocyte aggregation and sedimentation in blood of normal subjects: Evidence of a dietary role for flavonoids. Internat J Vit Nutr Res 1973;43:494-503.
  3. Robbins RC. In vitro effects of penta-, hexa-, and hepta-methoxylated flavones on aggregation of cells in blood from hospitalized patients. J Clin Pharmacol 1973;13:271-5. PubMed
  4. Takanaga H, Ohnishi A, Yamada S, et al. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther 2000;293:230-6. DOI
  5. Feng SL, Yuan ZW, Yao XJ, et al. Tangeretin, a citrus pentamethoxyflavone, antagonizes ABCB1-mediated multidrug resistance by inhibiting its transport function. Pharmacol Res 2016;110:193-204. PubMed
  6. Li Y, Ning J, Wang Y, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36. PubMed
  7. Bajraktari-Sylejmani G, Weiss J. Potential risk of food-drug interactions: Citrus polymethoxyflavones and flavanones as inhibitors of the organic anion transporting polypeptides (OATP) 1B1, 1B3, and 2B1. Eur J Drug Metab Pharmacokinet. 2020;45(6):809-815. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Methoxylated Flavones: Common Questions

Does Methoxylated Flavones interact with prescription medications?
Yes. We list 893 medications with a known interaction with Methoxylated Flavones. Use the checker above to see how Methoxylated Flavones interacts with a specific drug.
How are Methoxylated Flavones interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Methoxylated Flavones with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Methoxylated Flavones interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What are Methoxylated Flavones?
They are plant compounds in the flavonoid family, often called polymethoxyflavones, found mainly in citrus peel. Common examples include nobiletin and tangeretin.
Do Methoxylated Flavones actually work?
Most evidence comes from lab and animal studies suggesting antioxidant and anti-inflammatory activity. There is not enough good human research to say they reliably treat or prevent any condition.
Are they safe to take?
They occur naturally in citrus foods, which are safe to eat, but the safety of concentrated supplements in humans is not well studied. Check with a pharmacist or doctor before using them.
Can I take them while pregnant or breastfeeding?
Because there is no reliable safety data, it is best to avoid concentrated supplements during pregnancy and breastfeeding and get these compounds from normal foods instead.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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