Methoxylated Flavones + Ethinyl estradiol, Levonogestrel
Ethinyl estradiol, Levonogestrel brand name: Lybrel.
Ethinyl estradiol, Levonogestrel falls into 3 drug categories that Methoxylated Flavones can interact with; the most serious is rated moderate. Some in vitro evidence suggests that methoxylated flavones might induce CYP1A2, possibly by increasing gene transcription.
Read the full interaction reportMethoxylated Flavones and Ethinyl estradiol, Levonogestrel
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Methoxylated Flavones interacts with whole categories of medication. Ethinyl estradiol, Levonogestrel falls into 3 of those categories, so it can interact with Methoxylated Flavones in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
1 of 3Why this applies to Ethinyl estradiol, Levonogestrel
Ethinyl estradiol, Levonogestrel falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Methoxylated Flavones interacts with.
Some drugs metabolized by CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), Pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline (Slo-bid, Theo-Dur, others), zileuton (Zyflo), Zolmitriptan (Zomig), and others.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist for your birth control pill (Lybrel). In some test-tube studies, methoxylated flavones from citrus peel may speed up a liver enzyme called CYP1A2, which is one pathway your body uses to clear the estrogen in this pill. If that sped-up clearance actually happened in people, the hormone levels could dip a little, and in theory that might make the pill slightly less reliable or lead to breakthrough spotting.
I want to be honest though: this is a theoretical concern. It comes from lab work only, the results were mixed, and it has never been reported in real patients. Everyday citrus in food is not a worry. If you're considering concentrated flavone supplements, just run it by your pharmacist or doctor first, since reliable contraception is too important to gamble on a maybe.
- Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52:673-751. DOI
- Li Y, Ning J, Wang Y, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36. PubMed
P-GLYCOPROTEIN SUBSTRATES
2 of 3Ethinyl estradiol, Levonogestrel also falls under P-GLYCOPROTEIN SUBSTRATES.
Some of these drugs include some chemotherapeutic agents (daunorubicin, docetaxel, etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), protease inhibitors (amprenavir, indinavir, nelfinavir, saquinavir), H2 antagonists (cimetidine, ranitidine), some calcium channel blockers (diltiazem, verapamil), corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist for your birth control pill (Lybrel). Citrus peel compounds called methoxylated flavones can block a transporter called P-glycoprotein in lab dishes. In theory, blocking that pump could let a bit more of the hormones (ethinyl estradiol and levonorgestrel) get absorbed, nudging your blood levels up. That might mean slightly more of the usual estrogen-type side effects, think nausea, breast tenderness, bloating, or headache.
The important part: this is only a theoretical, test-tube finding, not something proven in real people. The small amount of these compounds you'd get from eating citrus is very unlikely to matter. Concentrated supplements are less certain. There's no need to worry, but if you plan to take a supplement regularly, run it by your pharmacist or doctor first.
- Takanaga H, Ohnishi A, Yamada S, et al. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther 2000;293:230-6. DOI
- Feng SL, Yuan ZW, Yao XJ, et al. Tangeretin, a citrus pentamethoxyflavone, antagonizes ABCB1-mediated multidrug resistance by inhibiting its transport function. Pharmacol Res 2016;110:193-204. PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
3 of 3Ethinyl estradiol, Levonogestrel also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
Some drugs metabolized by CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), Pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline (Slo-bid, Theo-Dur, others), zileuton (Zyflo), Zolmitriptan (Zomig), and others.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Your birth control pill, Lybrel, contains two active hormones (ethinyl estradiol and levonorgestrel) that your body partly clears using a liver enzyme called CYP3A4. In test-tube studies, certain methoxylated flavones from citrus peel appear to slow that enzyme down. If that happened in real life, your hormone levels could edge up a bit, which might mean more of the usual estrogen-type effects like nausea, breast tenderness, bloating, or headaches.
Here's the reassuring part: this is only lab-based evidence, and it has never actually been reported in people. Everyday citrus in your diet is very unlikely to cause trouble. Concentrated supplement doses are the bigger unknown, so if you're considering one, run it by your pharmacist or doctor first.
- Li Y, Ning J, Wang Y, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Methoxylated Flavones Also Interacts With Other Medications
Methoxylated Flavones has 891 moderate known drug interactions in our database — the Ethinyl estradiol, Levonogestrel one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Methoxylated Flavones
We haven’t checked that one against Methoxylated Flavones yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Methoxylated Flavones. Pick one to open its full report.
See Every Supplement That Interacts With Ethinyl estradiol, Levonogestrel
This page covers Methoxylated Flavones only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ethinyl estradiol, Levonogestrel page lists 239 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 6 major · 195 moderate · 38 minor.
From our pharmacist’s overview on the Ethinyl estradiol, Levonogestrel page
“A daily birth control pill like Lybrel (ethinyl estradiol with levonorgestrel) only works when enough hormone stays in the bloodstream, and that is exactly what several supplements on this page can undermine. This list deserves genuine care, starting with the six major-rated entries.”
Reviewed by 2 · Jul 18, 2026
Where Methoxylated Flavones and Ethinyl estradiol, Levonogestrel Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#715 of 1,452 supplements looked up here in the last 7 days
#1,328 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Methoxylated Flavones
What is Methoxylated Flavones?
- Antioxidant support
- Circulation and blood vessel health
- Anti-inflammatory support
- Skin and aging support
- General 'metabolism' or wellness blends
Methoxylated flavones (often called polymethoxyflavones) are a group of plant compounds, found mainly in citrus peel, that include substances like nobiletin and tangeretin. Lab and animal studies suggest possible antioxidant and anti-inflammatory effects, but solid human research is very limited, so their real-world benefits are unproven. Talk with a pharmacist or doctor before using them, especially if you take medicines or are pregnant or breastfeeding.
Other Drugs & Methoxylated Flavones
Browse every other medication we’ve checked against Methoxylated Flavones — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
891 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Hydrocortisone ›
- Naproxen ›
- Doxycycline ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Tetracycline ›
- Lidocaine ›
- Ranitidine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Triazolam ›
- Zopiclone ›
- Ciprofloxacin ›
- Colchicine ›
- Fentanyl ›
- Oxybutynin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Apomorphine ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Doxorubicin ›
- Fluticasone ›
- Miconazole ›
- Morphine Sulfate ›
- Acetaminophen ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Ivermectin ›
- Ketoprofen ›
- Lofepramine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Methotrexate ›
- Nortriptyline ›
- Ofloxacin ›
Showing 60 of 891 moderate interactions — see all 891 on the Methoxylated Flavones page.
No interaction 1,938 drugs checked — show the list
We also checked Methoxylated Flavones against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Rosuvastatin ›
- Escitalopram ›
- Metoprolol ›
- Isotretinoin ›
- Tirzepatide ›
- Methamphetamine ›
- Docusate ›
- Valacyclovir ›
- Metformin ›
- Levothyroxine, Liothyronine ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Lisdexamfetamine ›
- Amphetamine ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Pregabalin ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Acyclovir ›
- Duloxetine ›
- Methylene Blue ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Bisoprolol ›
- Insulin Degludec, Liraglutide ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Ezetimibe ›
- Atenolol, Chlorthalidone ›
- Cephalexin ›
- Cyclopentolate ›
- Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Levetiracetam ›
- Sacubitril, Valsartan ›
- Levodopa ›
- Enalapril Maleate ›
- Canagliflozin, Metformin ›
- Aminophylline, Amobarbital, Ephedrine ›
- Thyroid Hormone ›
- Ephedrine, Phenobarbital, Theophylline ›
- Carbidopa, Levodopa ›
- Sulfamethoxazole, Trimethoprim ›
- Rosiglitazone Maleate ›
- Daunorubicin, Cytarabine ›
- Mannitol ›
- Valsartan ›
- Bupivacaine, Meloxicam ›
- Bismuth Subcarbonate, Calcium Carbonate, Opium ›
- Ceftolozane Sulfate, Tazobactam Sodium ›
- Alginic Acid, Aluminum Hydroxide ›
- Acarbose ›
- Spironolactone ›
Showing the 60 most looked-up of 1,938 medications checked with no known interaction — see the full Methoxylated Flavones list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Ethinyl estradiol, Levonogestrel Is Linked to Lower Levels of 7 Nutrients
Natural Medicines records Ethinyl estradiol, Levonogestrel as a medicine that can lower these. This is not an interaction with Methoxylated Flavones — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Ethinyl estradiol, Levonogestrel nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Methoxylated Flavones and Ethinyl estradiol, Levonogestrel Together: Common Questions
Can you take Methoxylated Flavones with Ethinyl estradiol, Levonogestrel?
Why are there 3 interactions listed for Methoxylated Flavones and Ethinyl estradiol, Levonogestrel?
How serious is the Methoxylated Flavones and Ethinyl estradiol, Levonogestrel interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Ethinyl estradiol, Levonogestrel and Methoxylated Flavones?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.