Herb & supplement monograph

Genistein Combined Polysaccharide Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Genistein Combined Polysaccharide interacts with medications. The heart of this page is the interaction list — every drug Genistein Combined Polysaccharide is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Genistein Combined Polysaccharide is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Genistein Combined Polysaccharide Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Genistein Combined Polysaccharide drug interaction appears low for most people. None of the listed interactions are rated major, and the large majority are minor, with the rest falling in the moderate range.

Interactions deserving the most attention

The interaction with the most direct human evidence involves caffeine. A small study in healthy women found that genistein taken daily for two weeks slowed the body's ability to clear caffeine, likely because it inhibits an enzyme the liver uses to break caffeine down. In practice, this could make caffeine's effects, such as jitteriness or trouble sleeping, feel stronger or last longer. There is also weaker, animal-only evidence that GCP may affect medications cleared by the CYP2C9 enzyme, so a little extra caution is reasonable there.

What the rest of the list means

A long list of interactions does not mean each combination is harmful. Most entries here are minor and rest on lab or animal findings about how GCP might affect the enzymes that process medications, rather than on proven problems in people. These theoretical effects have not been shown to cause meaningful changes for most medicines.

Check your medications against Genistein Combined Polysaccharide

Based on HelloPharmacist’s Genistein Combined Polysaccharide interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Genistein Combined Polysaccharide

140 medications have a known interaction with Genistein Combined Polysaccharide, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Acetaminophen, Butalbital, Caffeine interaction Acetaminophen, Butalbital, Caffeine drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Caffeine, IsomethepteneMigralam
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Acetaminophen, Caffeine, Isometheptene interaction
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Acetaminophen, Caffeine, Pyrilamine interaction
Aspirin, Butalbital, CaffeineFiorinal
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Aspirin, Butalbital, Caffeine interaction Aspirin, Butalbital, Caffeine drug page: uses, dosage & side effects
Aspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Aspirin, Butalbital, Caffeine, Codeine Phosphate interaction
Aspirin, Butalbital, Caffeine, PhenacetinMarnal
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Aspirin, Butalbital, Caffeine, Phenacetin interaction
Aspirin, CaffeineAnacin
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Aspirin, Caffeine interaction
Aspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Aspirin, Caffeine, Codeine Phosphate interaction
Aspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Aspirin, Caffeine, Dihydrocodeine Bitartrate interaction
Aspirin, Caffeine, Dover's PwdAcedoval, Dovacet
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Aspirin, Caffeine, Dover's Pwd interaction
Aspirin, Caffeine, HydrocodoneDamason-P
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Aspirin, Caffeine, Hydrocodone interaction
Aspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interaction Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin drug page: uses, dosage & side effects
Aspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Aspirin, Caffeine, Orphenadrine interaction
Aspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Aspirin, Caffeine, Phenacetin, Propoxyphene interaction
Belladonna, Caffeine, Ergotamine, PentobarbitalMicomp PB
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Belladonna, Caffeine, Ergotamine, Pentobarbital interaction
Bellafoline, Caffeine, Ergotamine Tartrate, PentobarbitalCafergot PB
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interaction
Caffeine (otc Drug)Molie, Overtime, Vivarin
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Caffeine (otc Drug) interaction
Caffeine (prescription Drug)Caffeine, Dextrophin
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Caffeine (prescription Drug) interaction Caffeine (prescription Drug) drug page: uses, dosage & side effects
Caffeine , Sodium BenzoateCaffeine and Sodium Benzoate
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Caffeine , Sodium Benzoate interaction
Caffeine, Diphenhydramine, Ergotamine (prescription Drug)Ergodryl
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interaction
Caffeine, Ergotamine (prescription Drug)Migergot
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Caffeine, Ergotamine (prescription Drug) interaction
Caffeine, Ergotamine Tartrate (prescription Drug)Cafergot, Wigraine
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Caffeine, Ergotamine Tartrate (prescription Drug) interaction Caffeine, Ergotamine Tartrate (prescription Drug) drug page: uses, dosage & side effects
Caffeine, Potassium Salicylate, SalicylamideTrim-Elim
Moderate Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Read the full Genistein Combined Polysaccharide + Caffeine, Potassium Salicylate, Salicylamide interaction
AbrocitinibCibinqo
Minor Cytochrome P450 2c9 (cyp2c9) Substrates

Some evidence suggests that genistein can alter the pharmacokinetics of CYP2C9 substrates and should be used cautiously with them.

Read the full Genistein Combined Polysaccharide + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Genistein Combined Polysaccharide combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Genistein Combined Polysaccharide affects

Every type of medication (drug category) Genistein Combined Polysaccharide is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 2 drug categories Genistein Combined Polysaccharide interacts with
CaffeineCytochrome P450 2c9 (cyp2c9) Substrates
Caffeine

Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.
Taking genistein 1 gram daily for 14 days seems to inhibit caffeine clearance and metabolism in healthy females. This effect has been attributed to inhibition of the cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism.

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

Some evidence suggests that genistein can alter the pharmacokinetics of CYP2C9 substrates and should be used cautiously with them. This has only been seen in animal studies however. (PUBMED https://pubmed.ncbi.nlm.nih.gov/29387488/)

Likelihood Possible Evidence C
Monograph

Genistein Combined Polysaccharide: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Genistein Combined Polysaccharide (GCP) is a soy-and-mushroom supplement studied mostly for hormone-related cancers like prostate cancer, but solid human evidence is still limited. It should never replace standard cancer treatment, and you should talk with your oncologist and pharmacist before using it, especially if you have a hormone-sensitive condition.

Part used
Soybean-derived genistein combined with polysaccharides from basidiomycete mushrooms
Common forms
Capsules, tablets
People commonly use it for
  • Prostate cancer support
  • Bladder cancer support
  • Breast cancer support
  • Hormone-related cancers
  • Immune support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Human safety data is limited, so use only with medical guidance.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Genistein Combined Polysaccharide, often called GCP, is a dietary supplement made by combining a soybean extract with polysaccharides (a type of complex sugar) produced by certain mushrooms known as basidiomycetes. The soy part supplies genistein, a plant compound called an isoflavone that behaves somewhat like the hormone estrogen in the body.

The mushroom fermentation step is thought to change the genistein into a form the body may absorb more easily. GCP is sold mostly as capsules or tablets and is marketed largely toward people interested in supporting health during hormone-related cancers, such as prostate cancer.

It is important to understand that GCP is a manufactured supplement blend, not a traditional herb with a long history of use. Most of what is known about it comes from laboratory and early human studies.

How it works

The genistein in GCP is a phytoestrogen, meaning it can attach to estrogen receptors and produce weak estrogen-like or estrogen-blocking effects depending on the tissue. Researchers have proposed that genistein may slow the growth of certain cancer cells, encourage damaged cells to self-destruct (a process called apoptosis), and reduce the formation of new blood vessels that tumors need to grow.

The mushroom polysaccharides are believed to support immune activity and may help the body absorb the genistein in a more usable form. Some lab studies also suggest anti-inflammatory and antioxidant effects.

It is important to remember that most of these mechanisms come from test-tube and animal research. What happens in a lab dish does not always happen the same way in the human body.

Effectiveness

Does Genistein Combined Polysaccharide work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 1 use evaluated
1 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Genistein Combined Polysaccharide, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Cancer
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral genistein combined polysaccharide for the treatment of various forms of cancer, including breast cancer, bladder cancer, and prostate cancer, there is insufficient reliable information about the clinical effects of genistein combined polysaccharide for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Because GCP contains a phytoestrogen, anyone with a hormone-sensitive condition—such as breast, uterine, or ovarian cancer, endometriosis, or uterine fibroids—should be especially cautious and talk with their doctor before using it.

People being treated for cancer should always involve their oncology team, since supplements can interfere with treatment plans or testing. People with soy allergies should avoid GCP because it is soy-derived.

During pregnancy and breastfeeding, GCP should be avoided. Its estrogen-like activity and the lack of safety data make it an unnecessary risk during these times. Children should not use it. When in doubt, check with a pharmacist or physician first.

Side effects

GCP has not been studied enough to fully describe its side effects. Based on soy and isoflavone products in general, possible effects may include digestive upset, bloating, gas, or mild stomach discomfort.

Because genistein acts like estrogen, hormone-related effects are theoretically possible. Allergic reactions are possible in people sensitive to soy or mushrooms; stop use and seek care if you notice rash, itching, swelling, or trouble breathing.

Since long-term safety is not well established, report any new or unusual symptoms to your healthcare provider.

Genistein Combined Polysaccharide: Reported Adverse Effects

Documented safety reports on Genistein Combined Polysaccharide from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Bladder cancer Gastrointestinal

In one case report, a patient with bladder cancer taking genistein combined polysaccharide 5 grams daily experienced mild nausea and diarrhea.

  1. Capodice JL, Cammack AS, McKiernan JM, Katz AE. Two case reports on the use of genistein combined polysaccharide (GCP) against bladder cancer recurrence. J Complement Integr Med 2011;8.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no officially established or standardized dose for Genistein Combined Polysaccharide. Different products contain different amounts and formulations, so the right amount is not clear.

If you choose to use GCP, follow the directions on the specific product label and do not exceed them. Because supplements are not tightly regulated, product quality and content can vary widely.

The safest approach is to check with your pharmacist or doctor before starting, especially if you have a cancer diagnosis or a hormone-sensitive condition.

Pregnancy & Breastfeeding

Genistein Combined Polysaccharide & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Genistein Combined Polysaccharide & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Genistein Combined Polysaccharide monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. PubMed
  2. Capodice JL, Cammack AS, McKiernan JM, Katz AE. Two case reports on the use of genistein combined polysaccharide (GCP) against bladder cancer recurrence. J Complement Integr Med 2011;8. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Genistein Combined Polysaccharide: Common Questions

What is Genistein Combined Polysaccharide used for, and does it work?
People use Genistein Combined Polysaccharide for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Genistein Combined Polysaccharide interact with prescription medications?
Yes. We list 140 medications with a known interaction with Genistein Combined Polysaccharide. Use the checker above to see how Genistein Combined Polysaccharide interacts with a specific drug.
How are Genistein Combined Polysaccharide interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Genistein Combined Polysaccharide with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Genistein Combined Polysaccharide interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Genistein Combined Polysaccharide used for?
It is most often used in hopes of supporting health during hormone-related cancers, such as prostate, breast, and bladder cancer. However, strong human evidence that it works is lacking, so it should never replace standard medical treatment.
Is GCP safe to take?
Its overall safety is not well established because human studies are limited. People with hormone-sensitive conditions, soy allergies, or an active cancer diagnosis should be especially careful and talk to a doctor first.
Can I take GCP instead of my cancer treatment?
No. There is not enough evidence that GCP treats cancer, and using it in place of proven therapies like surgery, radiation, or chemotherapy could be dangerous. Always work with your oncology team.
Can I take GCP while pregnant or breastfeeding?
No. Because it acts like estrogen and has little safety data, it should be avoided during pregnancy and breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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