Tolbutamide

Generic name: Pronounced as (tole byoo' ta mide)
Brand names
  • Orinase®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 07/15/2017

Tolbutamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Tolbutamide is in a class of medications called sulfonylureas. Tolbutamide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Tolbutamide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

Tolbutamide comes as a tablet to take by mouth. It is usually taken once a day in the morning. Tell your doctor if tolbutamide upsets your stomach. Your doctor may tell you to take smaller doses of tolbutamide more than once a day. To help you remember to take tolbutamide, take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tolbutamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of tolbutamide and gradually increase your dose if needed. After you have taken tolbutamide for some time, tolbutamide may not control your blood sugar as well as it did at the beginning of your treatment. Your doctor may adjust the dose of your medication as needed so that the medication will work best for you. Be sure to tell your doctor how you are feeling and if your blood sugar test results have been higher or lower than normal at any time during your treatment.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking tolbutamide,

  • tell your doctor and pharmacist if you are allergic to tolbutamide, any other medications, or any of the ingredients in tolbutamide. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention anticoagulants ('blood thinners') such as warfarin (Coumadin); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Isoptin, Verelan); chloramphenicol; diuretics ('water pills'); fluconazole (Diflucan), hormone replacement therapy and hormonal contraceptives (birth control pills, patches, rings, implants, and injections); insulin or other medications to treat high blood sugar or diabetes; isoniazid (INH); MAO inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); medications for asthma and colds; medications for mental illness and nausea; miconazole (Monistat); niacin; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); phenytoin (Dilantin); probenecid (Benemid); salicylate pain relievers such as choline magnesium trisalicylate, choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan's, others), and salsalate (Argesic, Disalcid, Salgesic); sulfa antibiotics such as co-trimoxazole (Bactrim, Septra); sulfasalazine (Azulfidine); and thyroid medications. Also be sure to tell your doctor or pharmacist if you stop taking any medications while taking tolbutamide. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had G6PD deficiency (an inherited condition causing premature destruction of red blood cells or hemolytic anemia); if you have hormone disorders involving the adrenal, pituitary, or thyroid gland; or if you have heart, kidney, or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking tolbutamide, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking tolbutamide.

  • ask your doctor about the safe use of alcoholic beverages while you are taking tolbutamide. Alcohol can make the side effects from tolbutamide worse. Consuming alcohol while taking tolbutamide also may cause symptoms such as flushing (reddening of the face), headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety.

  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Tolbutamide may make your skin sensitive to sunlight.

  • ask your doctor what to do if you get sick, develop an infection or fever, experience unusual stress, or are injured. These conditions can affect your blood sugar and the amount of tolbutamide you may need.

Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthy diet, exercise regularly, and lose weight if necessary.

Before you start to take tolbutamide, ask you doctor what you should do if you forget to take a dose. Write these directions down so that you can refer to them later.

As a general rule, take the missed dose as soon as you remember it. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

  • Tolbutamide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • upper abdominal fullness

    • heartburn

    • rash

    • headache

    • changes in taste

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • yellowing of the skin or eyes

    • light-colored stools

    • dark urine

    • pain in the upper right part of the stomach

    • unusual bruising or bleeding

    • diarrhea

    • fever

    • sore throat

  • Tolbutamide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

  • In one study, people who took tolbutamide to treat their diabetes were more likely to die of heart problems than people who were treated with insulin and diet changes. Talk to your doctor about the risks of taking tolbutamide.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat, and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures

  • loss of consciousness

Keep all appointments with your doctor and the laboratory. Your blood sugar and urine sugar levels should be checked regularly to determine your response to tolbutamide. Your doctor may order other lab tests, including glycosylated hemoglobin (HbA1c), to check your response to tolbutamide. Your doctor will also tell you how to check your response to this medication by measuring your blood or urine sugar levels at home. Follow these instructions carefully.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking tolbutamide.

You should always wear a diabetic identification bracelet to be sure you get proper treatment in an emergency.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The therapeutic efficacy of Tolbutamide can be increased when used in combination with Moxifloxacin.
Repaglinide Repaglinide The metabolism of Tolbutamide can be decreased when combined with Repaglinide.
Montelukast Montelukast The metabolism of Tolbutamide can be decreased when combined with Montelukast.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The risk or severity of hypoglycemia can be increased when Insulin glargine is combined with Tolbutamide.
Leflunomide Leflunomide The serum concentration of Tolbutamide can be increased when it is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Tolbutamide can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Tolbutamide can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Tolbutamide can be decreased when combined with Atorvastatin.
Candesartan Candesartan The metabolism of Tolbutamide can be decreased when combined with Candesartan.
Cilostazol Cilostazol Tolbutamide may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Clopidogrel Clopidogrel The metabolism of Tolbutamide can be decreased when combined with Clopidogrel.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Conjugated estrogens.
Fenofibrate Fenofibrate The risk or severity of hypoglycemia can be increased when Fenofibrate is combined with Tolbutamide.
Guanfacine Guanfacine Guanfacine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Magnesium Hydroxide Magnesium Hydroxide Tolbutamide may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Miglitol Miglitol The risk or severity of hypoglycemia can be increased when Miglitol is combined with Tolbutamide.
Mycophenolate Mycophenolate Mycophenolic acid may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Olsalazine Olsalazine Olsalazine may increase the hypoglycemic activities of Tolbutamide.
Paregoric Paregoric The metabolism of Tolbutamide can be decreased when combined with Morphine.
Penbutolol Penbutolol The therapeutic efficacy of Tolbutamide can be increased when used in combination with Acebutolol.
Potassium Potassium Potassium may increase the excretion rate of Tolbutamide which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone The risk or severity of hyperglycemia can be increased when Prednisone is combined with Tolbutamide.
Ranitidine Ranitidine The serum concentration of Tolbutamide can be increased when it is combined with Ranitidine.
Reserpine Reserpine Reserpine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Rizatriptan Rizatriptan Rizatriptan may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Sumatriptan Sumatriptan The therapeutic efficacy of Tolbutamide can be increased when used in combination with Sumatriptan.
Tacrolimus Tacrolimus The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Tacrolimus.
Triamcinolone Triamcinolone The risk or severity of hyperglycemia can be increased when Triamcinolone is combined with Tolbutamide.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection The serum concentration of Tolbutamide can be increased when it is combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection The therapeutic efficacy of Tolbutamide can be increased when used in combination with Levofloxacin.
Meperidine Injection Meperidine Injection Meperidine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of hyperglycemia can be increased when Methylprednisolone is combined with Tolbutamide.
Metoclopramide Injection Metoclopramide Injection Tolbutamide may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Metronidazole Injection Metronidazole Injection The metabolism of Tolbutamide can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Tolbutamide can be decreased when combined with Morphine.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Tolbutamide may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Tolbutamide can be decreased when combined with Zidovudine.
Altretamine Altretamine Amphetamine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Cyclosporine Cyclosporine Cyclosporine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Ondansetron Ondansetron The metabolism of Tolbutamide can be decreased when combined with Ondansetron.
Torsemide Torsemide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Torasemide.
Olanzapine Olanzapine The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Olanzapine.
Alosetron Alosetron The metabolism of Tolbutamide can be decreased when combined with Alosetron.
Hydroxychloroquine Hydroxychloroquine The therapeutic efficacy of Tolbutamide can be increased when used in combination with Hydroxychloroquine.
Meloxicam Meloxicam The protein binding of Tolbutamide can be decreased when combined with Meloxicam.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Temozolomide Temozolomide Temozolomide may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Zaleplon Zaleplon Zaleplon may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Anakinra Anakinra The metabolism of Tolbutamide can be increased when combined with Anakinra.
Linezolid Linezolid Linezolid may increase the hypoglycemic activities of Tolbutamide.
Trimipramine Trimipramine The metabolism of Tolbutamide can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Tolbutamide can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Tolbutamide can be decreased when combined with Modafinil.
Perindopril Perindopril Perindopril may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The protein binding of Tolbutamide can be decreased when combined with Choline magnesium trisalicylate.
Sirolimus Sirolimus The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Sirolimus.
Epinephrine Injection Epinephrine Injection The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Epinephrine.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Tolbutamide which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Escitalopram.
Zonisamide Zonisamide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Tolbutamide can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Aripiprazole.
Atomoxetine Atomoxetine Atomoxetine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Teriparatide.
Atazanavir Atazanavir The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Atazanavir.
Almotriptan Almotriptan The metabolism of Tolbutamide can be decreased when combined with Almotriptan.
Eletriptan Eletriptan The metabolism of Tolbutamide can be decreased when combined with Eletriptan.
Rosuvastatin Rosuvastatin The therapeutic efficacy of Tolbutamide can be increased when used in combination with Rosuvastatin.
Aprepitant Aprepitant The metabolism of Tolbutamide can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Emtricitabine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Memantine Memantine Memantine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tegaserod Tegaserod The metabolism of Tolbutamide can be decreased when combined with Tegaserod.
Tadalafil Tadalafil Tadalafil may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Fosamprenavir Fosamprenavir The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Fosamprenavir.
Gemifloxacin Gemifloxacin The therapeutic efficacy of Tolbutamide can be increased when used in combination with Gemifloxacin.
Progesterone Progesterone The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Tolbutamide.
Infliximab Injection Infliximab Injection The metabolism of Tolbutamide can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Tolbutamide can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline Protriptyline may decrease the hypoglycemic activities of Tolbutamide.
Rifaximin Rifaximin The metabolism of Tolbutamide can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Tolbutamide.
Norethindrone Norethindrone The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Norethisterone.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Bosentan Bosentan The metabolism of Tolbutamide can be increased when combined with Bosentan.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Tolbutamide can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Tolbutamide can be decreased when combined with Eszopiclone.
Ganciclovir Ganciclovir Ganciclovir may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Insulin aspart.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Valganciclovir Valganciclovir Tolbutamide may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The serum concentration of Tolbutamide can be increased when it is combined with Voriconazole.
Adefovir Adefovir Adefovir may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Tolbutamide can be increased when combined with Peginterferon alfa-2b.
Pramlintide Injection Pramlintide Injection The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Pramlintide.
Exenatide Injection Exenatide Injection Exenatide may increase the hypoglycemic activities of Tolbutamide.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the hypoglycemic activities of Tolbutamide.
Ramelteon Ramelteon Ramelteon may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Fentanyl Fentanyl Fentanyl may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Pregabalin Pregabalin The risk or severity of hypoglycemia can be increased when Pregabalin is combined with Tolbutamide.
Deferasirox Deferasirox The metabolism of Tolbutamide can be decreased when combined with Deferasirox.
Tipranavir Tipranavir The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Tipranavir.
Felbamate Felbamate The metabolism of Tolbutamide can be decreased when combined with Felbamate.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Insulin detemir.
Ranolazine Ranolazine Ranolazine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Abatacept Injection Abatacept Injection The metabolism of Tolbutamide can be increased when combined with Abatacept.
Rasagiline Rasagiline Tolbutamide may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Imatinib Imatinib The metabolism of Tolbutamide can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Sitagliptin may increase the hypoglycemic activities of Tolbutamide.
Varenicline Varenicline Tolbutamide may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Tolbutamide can be decreased when combined with Gefitinib.
Albuterol Albuterol Salbutamol may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Paliperidone Paliperidone The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Paliperidone.
Bortezomib Bortezomib The metabolism of Tolbutamide can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Insulin glulisine.
Lubiprostone Lubiprostone Lubiprostone may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Bismuth Subsalicylate Bismuth Subsalicylate Bismuth subsalicylate may increase the hypoglycemic activities of Tolbutamide.
Darunavir Darunavir The therapeutic efficacy of Tolbutamide can be increased when used in combination with Darunavir.
Pemetrexed Injection Pemetrexed Injection Tolbutamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Nabilone Nabilone The metabolism of Tolbutamide can be decreased when combined with Nabilone.
Vorinostat Vorinostat The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Vorinostat.
Sorafenib Sorafenib The metabolism of Tolbutamide can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Sunitinib.
Dronabinol Dronabinol The metabolism of Tolbutamide can be decreased when combined with Dronabinol.
Lapatinib Lapatinib The metabolism of Tolbutamide can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine Tolbutamide may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Tolbutamide may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Armodafinil Armodafinil The metabolism of Tolbutamide can be decreased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Temsirolimus Temsirolimus The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Temsirolimus.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Tolbutamide can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Tolbutamide can be decreased when combined with Bexarotene.
Budesonide Budesonide The risk or severity of hyperglycemia can be increased when Tolbutamide is combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Tolbutamide can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Doripenem Injection Doripenem Injection Tolbutamide may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The metabolism of Tolbutamide can be decreased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Arsenic trioxide.
Desvenlafaxine Desvenlafaxine The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Desvenlafaxine.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Nebivolol Nebivolol The therapeutic efficacy of Tolbutamide can be increased when used in combination with Nebivolol.
Tretinoin Tretinoin The metabolism of Tolbutamide can be decreased when combined with Tretinoin.
Flecainide Flecainide The metabolism of Tolbutamide can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Tolbutamide can be increased when combined with Certolizumab pegol.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Tolbutamide may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Midazolam Midazolam Midazolam may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Tolbutamide can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Milnacipran.
Plerixafor Injection Plerixafor Injection Tolbutamide may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine Tolbutamide may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Betaxolol Betaxolol The therapeutic efficacy of Tolbutamide can be increased when used in combination with Betaxolol.
Iloperidone Iloperidone The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Iloperidone.
Prasugrel Prasugrel Tolbutamide may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Tolbutamide.
Everolimus Everolimus The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Tolbutamide which could result in a lower serum level and potentially a reduction in efficacy.
Pralatrexate Injection Pralatrexate Injection Tolbutamide may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Palonosetron may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Saxagliptin Saxagliptin Saxagliptin may increase the hypoglycemic activities of Tolbutamide.
Telavancin Injection Telavancin Injection Tolbutamide may decrease the excretion rate of Telavancin which could result in a higher serum level.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Tolbutamide.
Topotecan Topotecan Topotecan may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Golimumab Injection Golimumab Injection The metabolism of Tolbutamide can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Tolbutamide.
Asenapine Asenapine The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Asenapine.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Tolbutamide.
Ulipristal Ulipristal The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Ulipristal.
Levonorgestrel Levonorgestrel The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Levonorgestrel.
Liraglutide Injection Liraglutide Injection Liraglutide may increase the hypoglycemic activities of Tolbutamide.
Tocilizumab Injection Tocilizumab Injection The metabolism of Tolbutamide can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Tolbutamide may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Tolbutamide.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Lurasidone Lurasidone The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Lurasidone.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Ipilimumab Injection Ipilimumab Injection Tolbutamide may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Roflumilast Roflumilast Tolbutamide may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin Linagliptin Linagliptin may increase the hypoglycemic activities of Tolbutamide.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Potassium Iodide.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Tolbutamide can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Tolbutamide can be decreased when combined with Abiraterone.
Triptorelin Injection Triptorelin Injection The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Triptorelin.
Rivaroxaban Rivaroxaban Tolbutamide may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The metabolism of Tolbutamide can be decreased when combined with Ticagrelor.
Ruxolitinib Ruxolitinib Tolbutamide may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam Clobazam may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Vemurafenib Vemurafenib The metabolism of Tolbutamide can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Tolbutamide can be decreased when combined with Vismodegib.
Deferiprone Deferiprone Tolbutamide may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Naloxone Injection Naloxone Injection Tolbutamide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Enzalutamide Enzalutamide The metabolism of Tolbutamide can be decreased when combined with Enzalutamide.
Mirabegron Mirabegron Tolbutamide may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Tolbutamide can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Tolbutamide can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of hyperglycemia can be increased when Corticotropin is combined with Tolbutamide.
Teriflunomide Teriflunomide The serum concentration of Tolbutamide can be increased when it is combined with Teriflunomide.
Lorcaserin Lorcaserin The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Mecasermin.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Tolbutamide can be decreased when combined with Cabozantinib.
Teduglutide Injection Teduglutide Injection Tolbutamide may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin Alogliptin may increase the hypoglycemic activities of Tolbutamide.
Ponatinib Ponatinib The metabolism of Tolbutamide can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide Tolbutamide may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Tolbutamide.
Canagliflozin Canagliflozin Canagliflozin may increase the hypoglycemic activities of Tolbutamide.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Tolbutamide which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The metabolism of Tolbutamide can be decreased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Tolbutamide.
Trametinib Trametinib The metabolism of Tolbutamide can be decreased when combined with Trametinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Tolbutamide.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Tolbutamide.
Ketorolac Injection Ketorolac Injection The protein binding of Tolbutamide can be decreased when combined with Ketorolac.
Simeprevir Simeprevir The therapeutic efficacy of Tolbutamide can be increased when used in combination with Simeprevir.
Sofosbuvir Sofosbuvir Tolbutamide may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the hypoglycemic activities of Tolbutamide.
Apremilast Apremilast The metabolism of Tolbutamide can be increased when combined with Apremilast.
Droxidopa Droxidopa Tolbutamide may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Tolbutamide can be increased when combined with Siltuximab.
Albiglutide Injection Albiglutide Injection Albiglutide may increase the hypoglycemic activities of Tolbutamide.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Oritavancin Injection Oritavancin Injection The metabolism of Tolbutamide can be decreased when combined with Oritavancin.
Empagliflozin Empagliflozin The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Empagliflozin.
Dulaglutide Injection Dulaglutide Injection Dulaglutide may increase the hypoglycemic activities of Tolbutamide.
Edoxaban Edoxaban Tolbutamide may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Methamphetamine Methamphetamine Tolbutamide may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon Tolbutamide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Tolbutamide.
Lanreotide Injection Lanreotide Injection The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Lanreotide.
Secukinumab Injection Secukinumab Injection The metabolism of Tolbutamide can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Risperidone.
Insulin Human Inhalation Insulin Human Inhalation The risk or severity of hypoglycemia can be increased when Insulin human is combined with Tolbutamide.
Lenvatinib Lenvatinib The metabolism of Tolbutamide can be decreased when combined with Lenvatinib.
Haloperidol Injection Haloperidol Injection The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Haloperidol.
Amiloride Amiloride Amiloride may increase the excretion rate of Tolbutamide which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Tolbutamide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Prednisolone Prednisolone The risk or severity of hyperglycemia can be increased when Prednisolone is combined with Tolbutamide.
Brexpiprazole Brexpiprazole The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Ziprasidone.
Penicillin G Procaine Injection Penicillin G Procaine Injection Tolbutamide may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Insulin degludec.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Tolbutamide.
Ixazomib Ixazomib Tolbutamide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Tolbutamide can be increased when combined with Rifapentine.
Lesinurad Lesinurad Tolbutamide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The risk or severity of hyperglycemia can be increased when Dexamethasone is combined with Tolbutamide.
Brivaracetam Injection Brivaracetam Injection Tolbutamide may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Tolbutamide.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Tolbutamide can be decreased when combined with Diphenhydramine.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Tolbutamide can be increased when used in combination with Furosemide.
Rucaparib Rucaparib The metabolism of Tolbutamide can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Lixisenatide may increase the hypoglycemic activities of Tolbutamide.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Parathyroid hormone.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Tolbutamide.
Doxepin (Insomnia) Doxepin (Insomnia) Tolbutamide may decrease the hypoglycemic activities of Doxepin.
Deutetrabenazine Deutetrabenazine Tolbutamide may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Tolbutamide may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The risk or severity of hyperglycemia can be increased when Deflazacort is combined with Tolbutamide.
Safinamide Safinamide The metabolism of Tolbutamide can be decreased when combined with Safinamide.
Edaravone Injection Edaravone Injection The excretion of Edaravone can be decreased when combined with Tolbutamide.
Naldemedine Naldemedine Tolbutamide may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Tolbutamide can be decreased when combined with Midostaurin.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Abaloparatide.
Enasidenib Enasidenib The metabolism of Tolbutamide can be decreased when combined with Enasidenib.
Benznidazole Benznidazole Tolbutamide may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin The therapeutic efficacy of Tolbutamide can be increased when used in combination with Delafloxacin.
Letermovir Letermovir The metabolism of Tolbutamide can be decreased when combined with Letermovir.
Semaglutide Injection Semaglutide Injection Semaglutide may increase the hypoglycemic activities of Tolbutamide.
Ertugliflozin Ertugliflozin The therapeutic efficacy of Tolbutamide can be increased when used in combination with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection The metabolism of Tolbutamide can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Apalutamide can be decreased when combined with Tolbutamide.
Avatrombopag Avatrombopag The metabolism of Tolbutamide can be increased when combined with Avatrombopag.
Baricitinib Baricitinib Tolbutamide may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine Tolbutamide may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Tolbutamide may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Tolbutamide.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Tolbutamide.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Tolbutamide.
Stiripentol Stiripentol The metabolism of Tolbutamide can be decreased when combined with Stiripentol.
Glasdegib Glasdegib The metabolism of Glasdegib can be decreased when combined with Tolbutamide.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Tolbutamide.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Tolbutamide.
Rifamycin Rifamycin The metabolism of Tolbutamide can be increased when combined with Rifamycin.
Prucalopride Prucalopride Tolbutamide may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Tolbutamide can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Tolbutamide.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Tolbutamide.
Alpelisib Alpelisib The serum concentration of Tolbutamide can be decreased when it is combined with Alpelisib.
Solriamfetol Solriamfetol Tolbutamide may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Triclabendazole Triclabendazole The metabolism of Tolbutamide can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Tolbutamide.
Pitolisant Pitolisant Tolbutamide may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Phenytoin Injection Phenytoin Injection The serum concentration of Phenytoin can be increased when it is combined with Tolbutamide.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Fosphenytoin can be increased when it is combined with Tolbutamide.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Tolbutamide.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Tolbutamide.
Cenobamate Cenobamate The metabolism of Tolbutamide can be increased when combined with Cenobamate.
Teprotumumab-trbw Injection Teprotumumab-trbw Injection The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Teprotumumab.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Tolbutamide.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Tolbutamide.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Tolbutamide.
Selpercatinib Selpercatinib The serum concentration of Tolbutamide can be increased when it is combined with Selpercatinib.
Octreotide Octreotide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Octreotide.
Pralsetinib Pralsetinib The metabolism of Tolbutamide can be decreased when combined with Pralsetinib.
Opicapone Opicapone The metabolism of Tolbutamide can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Tolbutamide can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Drospirenone.
Viloxazine Viloxazine Tolbutamide may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Theophylline Theophylline The metabolism of Tolbutamide can be decreased when combined with Theophylline.
Fenoprofen Fenoprofen The protein binding of Tolbutamide can be decreased when combined with Fenoprofen.
Indomethacin Indomethacin The protein binding of Tolbutamide can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The protein binding of Tolbutamide can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The protein binding of Tolbutamide can be decreased when combined with Naproxen.
Tolmetin Tolmetin The protein binding of Tolbutamide can be decreased when combined with Tolmetin.
Sulindac Sulindac The protein binding of Tolbutamide can be decreased when combined with Sulindac.
Isotretinoin Isotretinoin Isotretinoin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Floxuridine Floxuridine The metabolism of Tolbutamide can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Tolbutamide can be decreased when combined with Phenobarbital.
Metaxalone Metaxalone Metaxalone may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Primidone Primidone The metabolism of Tolbutamide can be decreased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of hypoglycemia can be increased when Methsuximide is combined with Tolbutamide.
Chlorpromazine Chlorpromazine The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Chlorpromazine.
Diazepam Diazepam Diazepam may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Oxazepam Oxazepam Oxazepam may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Flurazepam Flurazepam Flurazepam may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Clorazepate Clorazepate Clorazepic acid may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Lorazepam Lorazepam Lorazepam may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Carmustine Carmustine Carmustine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Amantadine Amantadine Amantadine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Codeine Codeine Codeine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Bromocriptine Bromocriptine The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Tolbutamide can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Tolbutamide can be decreased when combined with Phenelzine.
Procarbazine Procarbazine Procarbazine may increase the hypoglycemic activities of Tolbutamide.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Prochlorperazine Prochlorperazine The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Prochlorperazine.
Thioridazine Thioridazine The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Thioridazine.
Trifluoperazine Trifluoperazine The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Trifluoperazine.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Dapsone Dapsone The metabolism of Tolbutamide can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The therapeutic efficacy of Tolbutamide can be increased when used in combination with Sulfadiazine.
Methadone Methadone The metabolism of Tolbutamide can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Tolbutamide can be decreased when combined with Oxybutynin.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Maprotiline Maprotiline Maprotiline may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Ibuprofen Ibuprofen The protein binding of Tolbutamide can be decreased when combined with Ibuprofen.
Perphenazine Perphenazine The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Perphenazine.
Azathioprine Azathioprine Azathioprine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Fluphenazine Fluphenazine The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Fluphenazine.
Phentermine Phentermine The therapeutic efficacy of Tolbutamide can be increased when used in combination with Phentermine.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Amoxapine Amoxapine Amoxapine may decrease the hypoglycemic activities of Tolbutamide.
Sulfasalazine Sulfasalazine Sulfasalazine may increase the hypoglycemic activities of Tolbutamide.
Hydrocortisone Hydrocortisone The risk or severity of hyperglycemia can be increased when Hydrocortisone is combined with Tolbutamide.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Carbamazepine Carbamazepine Tolbutamide may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Hydralazine Hydralazine Tolbutamide may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine The serum concentration of Tolbutamide can be increased when it is combined with Cimetidine.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Warfarin Warfarin The therapeutic efficacy of Warfarin can be increased when used in combination with Tolbutamide.
Clonazepam Clonazepam Clonazepam may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Loperamide Loperamide The metabolism of Tolbutamide can be decreased when combined with Loperamide.
Promethazine Promethazine The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Promethazine.
Meclofenamate Meclofenamate The protein binding of Tolbutamide can be decreased when combined with Meclofenamic acid.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Tolbutamide can be increased when combined with Griseofulvin.
Digoxin Digoxin Tolbutamide may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine The metabolism of Tolbutamide can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Tolbutamide can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of hypoglycemia can be increased when Ethosuximide is combined with Tolbutamide.
Triamterene Triamterene Triamterene may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Sulfinpyrazone Sulfinpyrazone The metabolism of Tolbutamide can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Chlorothiazide.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Chlorthalidone.
Metolazone Metolazone The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Metolazone.
Isosorbide Isosorbide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Isosorbide.
Secobarbital Secobarbital The metabolism of Tolbutamide can be increased when combined with Secobarbital.
Desipramine Desipramine Desipramine may decrease the hypoglycemic activities of Tolbutamide.
Amitriptyline Amitriptyline The metabolism of Tolbutamide can be decreased when combined with Amitriptyline.
Imipramine Imipramine Imipramine may decrease the hypoglycemic activities of Tolbutamide.
Probenecid Probenecid The protein binding of Tolbutamide can be decreased when combined with Probenecid.
Quinidine Quinidine Quinidine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Procainamide Procainamide Tolbutamide may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid The metabolism of Tolbutamide can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Rifampin Rifampin The serum concentration of Tolbutamide can be decreased when it is combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of hypoglycemia can be increased when Disopyramide is combined with Tolbutamide.
Valproic Acid Valproic Acid The metabolism of Tolbutamide can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Tolbutamide can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Levothyroxine Levothyroxine The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Levothyroxine.
Liothyronine Liothyronine The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Liothyronine.
Methimazole Methimazole The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Methimazole.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Propylthiouracil.
Chlorpropamide Chlorpropamide The risk or severity of hypoglycemia can be increased when Chlorpropamide is combined with Tolbutamide.
Tolazamide Tolazamide The risk or severity of hypoglycemia can be increased when Tolazamide is combined with Tolbutamide.
Dextromethorphan Dextromethorphan The metabolism of Tolbutamide can be decreased when combined with Dextromethorphan.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Tolbutamide.
Niacin Niacin The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Niacin.
Baclofen Baclofen The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Baclofen.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Hydrochlorothiazide.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Danazol Danazol The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Danazol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The therapeutic efficacy of Tolbutamide can be increased when used in combination with Propranolol.
Pseudoephedrine Pseudoephedrine The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Pseudoephedrine.
Nortriptyline Nortriptyline Nortriptyline may decrease the hypoglycemic activities of Tolbutamide.
Spironolactone Spironolactone The metabolism of Tolbutamide can be decreased when combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Nadolol Nadolol The therapeutic efficacy of Tolbutamide can be increased when used in combination with Nadolol.
Allopurinol Allopurinol The metabolism of Tolbutamide can be decreased when combined with Allopurinol.
Fluoxymesterone Fluoxymesterone Fluoxymesterone may increase the hypoglycemic activities of Tolbutamide.
Flavoxate Flavoxate Tolbutamide may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The metabolism of Tolbutamide can be decreased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Tolbutamide can be decreased when combined with Colchicine.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Dacarbazine Dacarbazine Dacarbazine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Acetazolamide Acetazolamide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Salmon calcitonin.
Ketoconazole Ketoconazole The metabolism of Tolbutamide can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel Tolbutamide may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Captopril Captopril The excretion of Captopril can be decreased when combined with Tolbutamide.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Etacrynic acid.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Metoprolol Metoprolol The therapeutic efficacy of Tolbutamide can be increased when used in combination with Metoprolol.
Aspirin Aspirin The risk or severity of hypoglycemia can be increased when Acetylsalicylic acid is combined with Tolbutamide.
Salsalate Salsalate The protein binding of Tolbutamide can be decreased when combined with Salsalate.
Alprazolam Alprazolam Alprazolam may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Temazepam Temazepam Temazepam may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Triazolam Triazolam Triazolam may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Dicyclomine Dicyclomine Dicyclomine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Propantheline Propantheline Propantheline may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Trimethoprim Trimethoprim The metabolism of Tolbutamide can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Tolbutamide can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Tolbutamide can be decreased when combined with Nifedipine.
Timolol Timolol The therapeutic efficacy of Tolbutamide can be increased when used in combination with Timolol.
Verapamil Verapamil The metabolism of Tolbutamide can be decreased when combined with Verapamil.
Atenolol Atenolol The therapeutic efficacy of Tolbutamide can be increased when used in combination with Atenolol.
Pindolol Pindolol The therapeutic efficacy of Tolbutamide can be increased when used in combination with Pindolol.
Cisplatin Injection Cisplatin Injection Tolbutamide may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may increase the hypoglycemic activities of Tolbutamide.
Piroxicam Piroxicam The protein binding of Tolbutamide can be decreased when combined with Piroxicam.
Bumetanide Bumetanide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Bumetanide.
Glyburide Glyburide The metabolism of Tolbutamide can be decreased when combined with Glyburide.
Glipizide Glipizide The risk or severity of hypoglycemia can be increased when Glipizide is combined with Tolbutamide.
Indapamide Indapamide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Indapamide.
Amoxicillin Amoxicillin Amoxicillin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Pentoxifylline Pentoxifylline Pentoxifylline may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Pentamidine.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Labetalol Labetalol The therapeutic efficacy of Tolbutamide can be increased when used in combination with Labetalol.
Auranofin Auranofin Auranofin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Leuprolide.
Gemfibrozil Gemfibrozil The metabolism of Tolbutamide can be decreased when combined with Gemfibrozil.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Ketoprofen Ketoprofen The protein binding of Tolbutamide can be decreased when combined with Ketoprofen.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Flurbiprofen Flurbiprofen The protein binding of Tolbutamide can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Tolbutamide.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Lovastatin Lovastatin The metabolism of Tolbutamide can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The therapeutic efficacy of Tolbutamide can be increased when used in combination with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may increase the hypoglycemic activities of Tolbutamide.
Diclofenac Diclofenac The protein binding of Tolbutamide can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The metabolism of Tolbutamide can be decreased when combined with Fluoxetine.
Nimodipine Nimodipine The risk or severity of hypoglycemia can be increased when Nimodipine is combined with Tolbutamide.
Clozapine Clozapine The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Clozapine.
Estazolam Estazolam Tolbutamide may decrease the excretion rate of Estazolam which could result in a higher serum level.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Tolbutamide.
Ofloxacin Ofloxacin The therapeutic efficacy of Tolbutamide can be increased when used in combination with Ofloxacin.
Didanosine Didanosine Didanosine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Clarithromycin Clarithromycin The serum concentration of Tolbutamide can be increased when it is combined with Clarithromycin.
Benazepril Benazepril The risk or severity of hypoglycemia can be increased when Benazepril is combined with Tolbutamide.
Etodolac Etodolac The protein binding of Tolbutamide can be decreased when combined with Etodolac.
Felodipine Felodipine The metabolism of Tolbutamide can be decreased when combined with Felodipine.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Nabumetone Nabumetone The protein binding of Tolbutamide can be decreased when combined with Nabumetone.
Simvastatin Simvastatin The metabolism of Tolbutamide can be decreased when combined with Simvastatin.
Amlodipine Amlodipine The risk or severity of hypoglycemia can be increased when Amlodipine is combined with Tolbutamide.
Teniposide Injection Teniposide Injection The metabolism of Tolbutamide can be decreased when combined with Teniposide.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Oxaprozin Oxaprozin The protein binding of Tolbutamide can be decreased when combined with Oxaprozin.
Atovaquone Atovaquone The metabolism of Tolbutamide can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Tolbutamide can be increased when combined with Rifabutin.
Sotalol Sotalol The risk or severity of hypoglycemia can be increased when Sotalol is combined with Tolbutamide.
Bisoprolol Bisoprolol The therapeutic efficacy of Tolbutamide can be increased when used in combination with Bisoprolol.
Zolpidem Zolpidem The metabolism of Tolbutamide can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The metabolism of Tolbutamide can be decreased when combined with Doxazosin.
Isradipine Isradipine The risk or severity of hypoglycemia can be increased when Isradipine is combined with Tolbutamide.
Omeprazole Omeprazole The metabolism of Tolbutamide can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Tolbutamide can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Tolbutamide can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of hypoglycemia can be increased when Venlafaxine is combined with Tolbutamide.
Stavudine Stavudine The excretion of Stavudine can be decreased when combined with Tolbutamide.
Fluvoxamine Fluvoxamine The metabolism of Tolbutamide can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of hypoglycemia can be increased when Lamotrigine is combined with Tolbutamide.
Losartan Losartan The metabolism of Tolbutamide can be decreased when combined with Losartan.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tramadol Tramadol Tramadol may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Lansoprazole Lansoprazole The metabolism of Tolbutamide can be decreased when combined with Lansoprazole.
Alprostadil Urogenital Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Tolbutamide.
Ifosfamide Injection Ifosfamide Injection The metabolism of Tolbutamide can be increased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Tolbutamide can be decreased when combined with Nicardipine.
Bupropion Bupropion Tolbutamide may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Saquinavir Saquinavir The metabolism of Tolbutamide can be decreased when combined with Saquinavir.
Metformin Metformin The risk or severity of hypoglycemia can be increased when Metformin is combined with Tolbutamide.
Nisoldipine Nisoldipine The risk or severity of hypoglycemia can be increased when Nisoldipine is combined with Tolbutamide.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Acarbose Acarbose The risk or severity of hypoglycemia can be increased when Acarbose is combined with Tolbutamide.
Glimepiride Glimepiride The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Tolbutamide.
Anastrozole Anastrozole The metabolism of Tolbutamide can be decreased when combined with Anastrozole.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Indinavir Indinavir The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Indinavir.
Ritonavir Ritonavir The metabolism of Tolbutamide can be decreased when combined with Ritonavir.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Clomipramine Clomipramine Clomipramine may decrease the hypoglycemic activities of Tolbutamide.
Zafirlukast Zafirlukast The metabolism of Tolbutamide can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Topiramate Topiramate Topiramate may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Zileuton Zileuton The metabolism of Tolbutamide can be decreased when combined with Zileuton.
Valsartan Valsartan The metabolism of Tolbutamide can be decreased when combined with Valsartan.
Insulin Lispro Injection Insulin Lispro Injection The risk or severity of hypoglycemia can be increased when Insulin lispro is combined with Tolbutamide.
Pramipexole Pramipexole Pramipexole may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Donepezil Donepezil The metabolism of Tolbutamide can be decreased when combined with Donepezil.
Nelfinavir Nelfinavir The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Nelfinavir.
Loratadine Loratadine The metabolism of Tolbutamide can be decreased when combined with Loratadine.
Carvedilol Carvedilol The therapeutic efficacy of Tolbutamide can be increased when used in combination with Carvedilol.
Nilutamide Nilutamide The metabolism of Tolbutamide can be decreased when combined with Nilutamide.
Flutamide Flutamide Flutamide may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Selegiline Selegiline The metabolism of Tolbutamide can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Tolbutamide can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Tolbutamide can be decreased when combined with Sertraline.
Propafenone Propafenone The therapeutic efficacy of Tolbutamide can be increased when used in combination with Propafenone.
Raloxifene Raloxifene The metabolism of Tolbutamide can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Tolbutamide can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin The therapeutic efficacy of Tolbutamide can be increased when used in combination with Tamsulosin.
Quetiapine Quetiapine The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Paroxetine Paroxetine The metabolism of Tolbutamide can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Tolbutamide can be decreased when combined with Tolcapone.
Citalopram Citalopram The risk or severity of hypoglycemia can be increased when Citalopram is combined with Tolbutamide.
Capecitabine Capecitabine The metabolism of Tolbutamide can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Tolbutamide can be decreased when combined with Efavirenz.
Abacavir Abacavir Abacavir may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Tolbutamide can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone The therapeutic efficacy of Tolbutamide can be increased when used in combination with Pioglitazone.
Celecoxib Celecoxib The protein binding of Tolbutamide can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The therapeutic efficacy of Tolbutamide can be increased when used in combination with Rosiglitazone.
Tolterodine Tolterodine Tolterodine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Thalidomide Thalidomide The metabolism of Tolbutamide can be decreased when combined with Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may increase the hypoglycemic activities of Tolbutamide.
Nateglinide Nateglinide The risk or severity of hypoglycemia can be increased when Nateglinide is combined with Tolbutamide.
Rabeprazole Rabeprazole The metabolism of Tolbutamide can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Tolbutamide can be decreased when combined with Terbinafine.

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