Genistein Combined Polysaccharide - Amitriptyline, Chlordiazepoxide Interaction

Herbal: Genistein Combined Polysaccharide

Drug: Amitriptyline, Chlordiazepoxide
Brand names: Limbitrol DS

Medical Content Editor
Last updated Jun 26, 2023

Interaction Details

Amitriptyline, Chlordiazepoxide is classified as belonging to the following category: Cytochrome P450 2C9 (Cyp2C9) Substrates

Some evidence suggests that genistein can alter the pharmacokinetics of CYP2C9 substrates and should be used cautiously with them. This has only been seen in animal studies however. (PUBMED https://pubmed.ncbi.nlm.nih.gov/29387488/)

Interaction Rating

Minor

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

Genistein Combined Polysaccharide Overview

Genistein combined polysaccharide is a supplement that comes from soybeans and mushrooms. It has genistein, a plant chemical that acts like estrogen (i.e., a phytoestrogen), and polysaccharide, a kind of sugar that helps the immune system. Genistein combined polysaccharide is made by mixing soy extract with a group of mushrooms called basidiomycetes. People take genistein combined polysaccharide to prevent and treat different kinds of cancer, especially those that are affected by hormones, such as breast cancer, prostate cancer, and bladder cancer. Some research suggests that genistein may stop cancer cells from growing, kill them, cut off their blood supply, lower inflammation, and balance hormone levels but more research is needed to make sure genistein combined polysaccharide is safe and effective for different health problems.
See More Information Regarding Genistein Combined Polysaccharide

Genistein Combined Polysaccharide - More Interactions

Genistein Combined Polysaccharide interacts with 138 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

Dr. Brian Staiger, PharmD

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Dr. Brian Staiger, PharmD

In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

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