Drug & supplement interaction

Genistein Combined Polysaccharide + Glimepiride

Glimepiride brand name: Amaryl.

Minor Interaction
Medically reviewed by · Updated June 2023
The bottom line Minor

Genistein Combined Polysaccharide has a minor interaction with Glimepiride. Some evidence suggests that genistein can alter the pharmacokinetics of CYP2C9 substrates and should be used cautiously with them.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Genistein Combined Polysaccharide and Glimepiride

Here is the interaction we found between these two, with the evidence behind it.

Minor

Cytochrome P450 2C9 (Cyp2C9) Substrates

Why this applies to Glimepiride

Glimepiride falls under Cytochrome P450 2C9 (Cyp2C9) Substrates — the group Genistein Combined Polysaccharide interacts with.

Some evidence suggests that genistein can alter the pharmacokinetics of CYP2C9 substrates and should be used cautiously with them. This has only been seen in animal studies however. (PUBMED https://pubmed.ncbi.nlm.nih.gov/29387488/)
Severity Minor Likelihood Possible Evidence C

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the short version: your body relies on a liver enzyme called CYP2C9 to clear glimepiride. In animal studies, the genistein in GCP appeared to slow that enzyme down a bit. If the same thing happened in people, glimepiride could hang around a little longer than usual, which in theory might nudge your blood sugar lower and slightly raise the chance of a low blood sugar episode (think shakiness, sweating, dizziness, or feeling foggy).

I want to be straight with you, though: this has only been seen in lab animals, not humans, and it's rated as a minor interaction. So I wouldn't lose sleep over it. Just keep an eye on your glucose readings, watch for low-sugar symptoms, and run GCP by your oncologist and pharmacist first, since they'll want to know everything you're taking.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Genistein Combined Polysaccharide Also Interacts With Other Medications

Genistein Combined Polysaccharide has 29 moderate, 110 minor known drug interactions in our database — the Glimepiride one above is one of them. If you take anything else, check it against the full list below.

Moderate 29 Minor 110 No known interaction 2,691 (incl. Glimepiride)
Taking anything else?

Check Another of Your Medications Against Genistein Combined Polysaccharide

Covers the 2,830 medications we’ve checked against Genistein Combined Polysaccharide. Pick one to open its full report.

From our Q&A

Questions About Genistein Combined Polysaccharide or Glimepiride

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Genistein Combined Polysaccharide or Glimepiride, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Glimepiride

This page covers Genistein Combined Polysaccharide only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glimepiride page lists 306 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 256 moderate · 48 minor.

From our pharmacist’s overview on the Glimepiride page

“Glimepiride (Amaryl) is a sulfonylurea, a diabetes pill that prompts the pancreas to release insulin, so anything that further lowers blood sugar can tip you into hypoglycemia, and that describes most of this list. Of the 306 supplement and herbal ingredients on file, 239 can move blood sugar on their own.”

Reviewed by 2 · Jul 18, 2026

Open the Glimepiride interaction page

How much people look this up

Where Genistein Combined Polysaccharide and Glimepiride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Genistein Combined Polysaccharide
Top half

#592 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glimepiride
Top half

#734 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Genistein Combined Polysaccharide

What is Genistein Combined Polysaccharide?

  • Prostate cancer support
  • Bladder cancer support
  • Breast cancer support
  • Hormone-related cancers
  • Immune support

Genistein Combined Polysaccharide (GCP) is a soy-and-mushroom supplement studied mostly for hormone-related cancers like prostate cancer, but solid human evidence is still limited. It should never replace standard cancer treatment, and you should talk with your oncologist and pharmacist before using it, especially if you have a hormone-sensitive condition.

Read the full Genistein Combined Polysaccharide monograph & all interactions
Medication

About Glimepiride

What Is Glimepiride Used For?

Brand name: Amaryl

Glimepiride tablets are used to improve blood sugar control in adults with type 2 diabetes. It is always used together with a healthy diet and regular exercise — it is not a replacement for those habits.

Glimepiride is not intended for type 1 diabetes or diabetic ketoacidosis (a serious complication where the body produces high levels of blood acids called ketones). It would not be effective in those situations.

See full Glimepiride drug information
Keep checking

Other Drugs & Genistein Combined Polysaccharide

Browse every other medication we’ve checked against Genistein Combined Polysaccharide — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
29Moderate
110Minor
2,690No known interaction
29 Moderate 110 Minor 2,690 No interaction
Moderate

29 interactions

Minor

110 interactions

Showing 60 of 110 minor interactions — see all 110 on the Genistein Combined Polysaccharide page.

No interaction 2,690 drugs checked — show the list

We also checked Genistein Combined Polysaccharide against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,690 medications checked with no known interaction — see the full Genistein Combined Polysaccharide list.

See the full Genistein Combined Polysaccharide interactions page
See every supplement checked against Glimepiride, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Genistein Combined Polysaccharide monograph › Uses, safety, and every drug interaction in one place Glimepiride supplement interactions › Every supplement checked against Glimepiride, ranked by severity Glimepiride drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Genistein Combined Polysaccharide and Glimepiride Together: Common Questions

Can you take Genistein Combined Polysaccharide with Glimepiride?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Genistein Combined Polysaccharide and Glimepiride interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Glimepiride and Genistein Combined Polysaccharide?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.