Buckhorn Plantain Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Buckhorn Plantain interacts with medications. The heart of this page is the interaction list — every drug Buckhorn Plantain is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Buckhorn Plantain is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Buckhorn Plantain against your medication
Add one medicationDrugs that interact with Buckhorn Plantain
0 medications have a known interaction with Buckhorn Plantain, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Buckhorn Plantain. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Buckhorn Plantain combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Buckhorn Plantain: Uses, Safety & Side Effects
Buckhorn plantain is a common weed-like herb used traditionally for coughs, sore throats, and minor skin wounds. Some lab and small studies suggest it has soothing and mild anti-inflammatory effects, but high-quality human evidence is limited. It is generally considered low-risk for short-term use, but pregnant and breastfeeding people should be cautious and check with a healthcare provider.

- Scientific name
- Plantago lanceolata
- Family
- Plantaginaceae
- Part used
- Leaves (above-ground parts)
- Common forms
- Tea, tincture, syrup, capsules, topical creams or ointments, fresh crushed leaves
- Cough and sore throat
- Respiratory irritation
- Wound and skin care
- Digestive upset
- Mild inflammation
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally considered low-risk for short-term use, but human safety data are limited.
When used orally or topically. Some evidence suggests buckhorn plantain affects muscle tone of the uterus.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Buckhorn plantain (Plantago lanceolata) is a low-growing herbaceous plant with narrow, lance-shaped leaves and small greenish-brown flower spikes. It is native to Europe but now grows as a common wild plant in many parts of the world, including North America. It is not related to the banana-like cooking plantain.
People have used this plant in traditional medicine for centuries. The leaves are the part most often used. They may be made into teas, syrups, tinctures, or applied to the skin. It is also sometimes eaten as a wild edible green.
Uses & effectiveness
Buckhorn plantain is most commonly used for coughs, sore throats, and irritated airways. Some herbal cough syrups in Europe contain plantain extract, and a few small studies and traditional reports suggest it may help soothe throat and airway irritation. Still, the human evidence is limited and not strong enough to call it proven.
It is also used on the skin for minor wounds, insect bites, and irritation, based on its traditional reputation as a soothing, mildly astringent herb. Other traditional uses include digestive upset and mild inflammation. For most of these uses, the evidence comes from laboratory studies, animal research, or long-standing folk use rather than large, well-designed human trials.
Overall, you should view buckhorn plantain as a traditional remedy with promising but unproven benefits. It is not a substitute for medical treatment of infections or serious conditions.
How it works
Buckhorn plantain contains several natural compounds that may explain its traditional uses. These include mucilage (a slippery, gel-like fiber), iridoid glycosides such as aucubin, flavonoids, and tannins.
The mucilage is thought to form a soothing coating that may calm an irritated throat or airway. Aucubin and the flavonoids have shown anti-inflammatory and antimicrobial effects in laboratory studies, and tannins have a mild astringent (tightening) action that may help with minor skin irritation.
It is important to know that most of this information comes from test-tube and animal research. How well these effects carry over to people taking the herb is not well established.
Safety & precautions
Buckhorn plantain is generally considered low-risk for most adults when used short-term in food-like or normal herbal amounts. However, formal safety studies in humans are limited.
People with allergies to plantain or related plants should avoid it. Because it has not been well studied, people with chronic medical conditions, those taking multiple medications, and older adults should check with a pharmacist or doctor first.
For pregnancy and breastfeeding, there is not enough reliable safety information. To be safe, it is best to avoid buckhorn plantain during these times unless your healthcare provider specifically approves it. Do not give herbal supplements to infants or young children without medical advice.
Side effects
When used in normal amounts, buckhorn plantain is usually well tolerated. Possible side effects include mild digestive upset or, rarely, an allergic reaction such as skin rash or itching.
Applied to the skin, it could occasionally cause irritation or a contact allergy in sensitive people. Stop using it and seek medical care if you have signs of a serious allergic reaction, such as swelling of the face or throat, trouble breathing, or widespread hives.
Dosing
There is no official standardized dose for buckhorn plantain. Traditional preparations include teas made from the dried leaves, syrups, tinctures, and topical products.
Because product strength varies a lot between brands and forms, the best approach is to follow the directions on the product label. If you are unsure how much to use, how often, or whether it is right for you, check with a pharmacist or doctor before starting.
Buckhorn Plantain & Pregnancy
Buckhorn Plantain & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 1 references that drive our Buckhorn Plantain monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Shipochliev T. Uterotonic action of extracts from a group of medicinal plants. Vet Med Nauki 1981;18:94-8.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Buckhorn Plantain
3 brands in our database make a supplement containing Buckhorn Plantain.
Supplement products with Buckhorn Plantain
4 products in our database contain Buckhorn Plantain. Open any to see its full ingredient list and every drug interaction we check.
Buckhorn Plantain: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Buckhorn Plantain
A rotating sample of real supplements in our database that list Buckhorn Plantain — open any to see its full ingredients and every drug interaction we check.
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