Herb & supplement monograph

Buckhorn Plantain Drug Interactions, Uses, Safety & More

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Interaction report

Drugs that interact with Buckhorn Plantain

0 medications have a known interaction with Buckhorn Plantain, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Buckhorn Plantain. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

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What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Buckhorn Plantain combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Buckhorn Plantain: Uses, Safety & Side Effects

The bottom line

Buckhorn plantain is a common weed-like herb used traditionally for coughs, sore throats, and minor skin wounds. Some lab and small studies suggest it has soothing and mild anti-inflammatory effects, but high-quality human evidence is limited. It is generally considered low-risk for short-term use, but pregnant and breastfeeding people should be cautious and check with a healthcare provider.

Buckhorn Plantain
Scientific name
Plantago lanceolata
Family
Plantaginaceae
Part used
Leaves (above-ground parts)
Common forms
Tea, tincture, syrup, capsules, topical creams or ointments, fresh crushed leaves
People commonly use it for
  • Cough and sore throat
  • Respiratory irritation
  • Wound and skin care
  • Digestive upset
  • Mild inflammation

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally considered low-risk for short-term use, but human safety data are limited.

PregnancyLikely Unsafe

When used orally or topically. Some evidence suggests buckhorn plantain affects muscle tone of the uterus.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Buckhorn plantain (Plantago lanceolata) is a low-growing herbaceous plant with narrow, lance-shaped leaves and small greenish-brown flower spikes. It is native to Europe but now grows as a common wild plant in many parts of the world, including North America. It is not related to the banana-like cooking plantain.

People have used this plant in traditional medicine for centuries. The leaves are the part most often used. They may be made into teas, syrups, tinctures, or applied to the skin. It is also sometimes eaten as a wild edible green.

Uses & effectiveness

Buckhorn plantain is most commonly used for coughs, sore throats, and irritated airways. Some herbal cough syrups in Europe contain plantain extract, and a few small studies and traditional reports suggest it may help soothe throat and airway irritation. Still, the human evidence is limited and not strong enough to call it proven.

It is also used on the skin for minor wounds, insect bites, and irritation, based on its traditional reputation as a soothing, mildly astringent herb. Other traditional uses include digestive upset and mild inflammation. For most of these uses, the evidence comes from laboratory studies, animal research, or long-standing folk use rather than large, well-designed human trials.

Overall, you should view buckhorn plantain as a traditional remedy with promising but unproven benefits. It is not a substitute for medical treatment of infections or serious conditions.

How it works

Buckhorn plantain contains several natural compounds that may explain its traditional uses. These include mucilage (a slippery, gel-like fiber), iridoid glycosides such as aucubin, flavonoids, and tannins.

The mucilage is thought to form a soothing coating that may calm an irritated throat or airway. Aucubin and the flavonoids have shown anti-inflammatory and antimicrobial effects in laboratory studies, and tannins have a mild astringent (tightening) action that may help with minor skin irritation.

It is important to know that most of this information comes from test-tube and animal research. How well these effects carry over to people taking the herb is not well established.

Safety & precautions

Buckhorn plantain is generally considered low-risk for most adults when used short-term in food-like or normal herbal amounts. However, formal safety studies in humans are limited.

People with allergies to plantain or related plants should avoid it. Because it has not been well studied, people with chronic medical conditions, those taking multiple medications, and older adults should check with a pharmacist or doctor first.

For pregnancy and breastfeeding, there is not enough reliable safety information. To be safe, it is best to avoid buckhorn plantain during these times unless your healthcare provider specifically approves it. Do not give herbal supplements to infants or young children without medical advice.

Side effects

When used in normal amounts, buckhorn plantain is usually well tolerated. Possible side effects include mild digestive upset or, rarely, an allergic reaction such as skin rash or itching.

Applied to the skin, it could occasionally cause irritation or a contact allergy in sensitive people. Stop using it and seek medical care if you have signs of a serious allergic reaction, such as swelling of the face or throat, trouble breathing, or widespread hives.

Dosing

There is no official standardized dose for buckhorn plantain. Traditional preparations include teas made from the dried leaves, syrups, tinctures, and topical products.

Because product strength varies a lot between brands and forms, the best approach is to follow the directions on the product label. If you are unsure how much to use, how often, or whether it is right for you, check with a pharmacist or doctor before starting.

Pregnancy & Breastfeeding

Buckhorn Plantain & Pregnancy

Likely Unsafe

When used orally or topically. Some evidence suggests buckhorn plantain affects muscle tone of the uterus.

  1. Shipochliev T. Uterotonic action of extracts from a group of medicinal plants. Vet Med Nauki 1981;18:94-8.

Buckhorn Plantain & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our Buckhorn Plantain monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Shipochliev T. Uterotonic action of extracts from a group of medicinal plants. Vet Med Nauki 1981;18:94-8.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Buckhorn Plantain

3 brands in our database make a supplement containing Buckhorn Plantain.

Pharmacist Counseling Corner

Buckhorn Plantain: Common Questions

Does Buckhorn Plantain interact with prescription medications?
We do not currently list any known drug interactions for Buckhorn Plantain. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Buckhorn Plantain interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Buckhorn Plantain with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Buckhorn Plantain interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Buckhorn Plantain used for?
It is traditionally used for coughs, sore throats, irritated airways, minor skin wounds, and digestive upset. Most of these uses are based on tradition and early research rather than strong human studies.
Is Buckhorn Plantain the same as a banana plantain?
No. Buckhorn Plantain is a small leafy herb (Plantago lanceolata) and is not related to the cooking plantain that looks like a banana.
Is Buckhorn Plantain safe to take?
It is generally considered low-risk for short-term use in normal amounts, but human safety data are limited. People with allergies, chronic conditions, or who take medicines should check with a pharmacist or doctor first.
Can I use Buckhorn Plantain while pregnant or breastfeeding?
There isn't enough reliable safety information for these times, so it is best to avoid it during pregnancy and breastfeeding unless your healthcare provider approves.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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