Tapentadol

Generic name: Pronounced as (ta pen' ta dol)
Brand names
  • Nucynta®
  • Nucynta® ER
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 10/04/2020

Tapentadol may be habit forming, especially with prolonged use. Take tapentadol exactly as directed. Do not take more of it, take it more often, or take it in a different way than directed by your doctor. While taking tapentadol, discuss with your healthcare provider your pain treatment goals, length of treatment, and other ways to manage your pain. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or has had an overdose, or if you have or have ever had depression or another mental illness. There is a greater risk that you will overuse tapentadol if you have or have ever had any of these conditions. Talk to your healthcare provider immediately and ask for guidance if you think that you have an opioid addiction or call the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-HELP.

Tapentadol may cause serious or life-threatening breathing problems, especially during the first 24 to 72 hours of your treatment and any time your dose is increased. Your doctor will adjust your dose to control your pain and decrease the risk that you will experience serious breathing problems. Tell your doctor if you have or have ever had slowed breathing or asthma. Your doctor will probably tell you not to take tapentadol. Also tell your doctor if you have or have ever had lung disease such as chronic obstructive pulmonary disease (COPD; a group of lung diseases that includes chronic bronchitis and emphysema), a head injury, a brain tumor, or any condition that increases the amount of pressure in your brain. The risk that you will develop breathing problems may be higher if you are an older adult or are weakened or malnourished due to disease. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: slowed breathing, long pauses between breaths, or shortness of breath.

Taking certain other medications during your treatment with tapentadol may increase the risk that you will experience breathing problems or other serious, life threatening breathing problems, sedation, or coma. Tell your doctor if you are taking or plan to take any of the following medications: benzodiazepines such as alprazolam (Xanax), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), and triazolam (Halcion); other narcotic pain medications; medications for mental illness or nausea; muscle relaxants; sedatives; sleeping pills; or tranquilizers. Your doctor may need to change the dosages of your medications and will monitor you carefully. If you take tapentadol with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.

Drinking alcohol, taking prescription or nonprescription medications that contain alcohol, or using street drugs during your treatment with tapentadol increases the risk that you will experience serious, life-threatening side effects. Do not drink alcohol, take prescription or nonprescription medications that contain alcohol, or use street drugs during your treatment with tapentadol.

Do not allow anyone else to take your medication. Tapentadol may harm or cause death to other people who take your medication, especially children. Keep tapentadol in a safe place so that no one else can take it accidentally or on purpose. Be especially careful to keep tapentadol out of the reach of children. Keep track of how many tablets or extended-release tablets are left so you will know if any medication is missing. Flush any tablets or extended-release tablets that are outdated or no longer needed down the toilet so that others will not take them.

If you are taking the extended-release tablets, swallow them whole; do not chew, break, divide, crush, or dissolve them. If you swallow broken, chewed, crushed, or dissolved extended-release tablets, you may receive too much tapentadol at once instead of slowly over 12 hours. This may cause serious problems, including overdose and death.

Tell your doctor if you are pregnant or plan to become pregnant. If you take tapentadol regularly during your pregnancy, your baby may experience life-threatening withdrawal symptoms after birth. Tell your baby's doctor right away if your baby experiences any of the following symptoms: irritability, hyperactivity, abnormal sleep, high-pitched cry, uncontrollable shaking of a part of the body, vomiting, diarrhea, or failure to gain weight.

Talk to your doctor about the risks of taking tapentadol.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin your treatment with tapentadol and each time you fill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Tapentadol tablets are used to treat moderate to severe acute pain (pain that begins suddenly, has a specific cause, and is expected to go away when the cause of the pain is healed). Tapentadol extended-release tablets are used to treat severe neuropathic pain (pain caused by nerve damage) in people who have diabetes. Tapentadol extended-release tablets are only used to treat people who are expected to need medication around-the-clock to relieve pain that cannot be controlled by the use of other pain medications. Tapentadol is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

Tapentadol comes as a tablet and an extended-release (long acting) tablet to take by mouth. The tablets are usually taken with or without food every 4 to 6 hours as needed. If you are taking tapentadol tablets, your doctor may tell you that you may take a second dose as soon as 1 hour after the first dose on your first day of treatment if needed to treat your pain. Do not take extra doses at any other time during your treatment and do not ever take extra doses of the extended-release tablets. The extended-release tablets are taken once every 12 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tapentadol exactly as directed.

If you are taking the extended-release tablets, swallow them one at a time with plenty of water. Swallow each tablet right after you put it in your mouth.

Your doctor will probably start you on a low dose of tapentadol and gradually increase your dose until your pain is controlled. Your doctor may adjust your dose at any time during your treatment if your pain is not controlled. If you feel that your pain is not controlled, call your doctor. Do not change the dose of your medication without talking to your doctor.

After you take tapentadol for a period of time, your body may become used to the medication. If this happens, your doctor may need to increase your dose of medication to control your pain. Talk to your doctor about how you are feeling during your treatment with tapentadol.

Do not stop taking tapentadol without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking tapentadol, you may experience withdrawal symptoms such as restlessness; anxiety; irritability; teary eyes; yawning; chills; sweating; difficulty falling asleep or staying asleep; shivering; uncontrollable shaking of a part of your body; muscle, back, or joint pain; weakness; nausea; vomiting; diarrhea; stomach cramps; loss of appetite; runny nose, sneezing, or coughing; hair on your skin standing on end; fast breathing; fast heartbeat; widening of the pupils (black circles in the middle of the eyes); or hallucinations (seeing things or hearing voices that do not exist).

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking tapentadol,

  • tell your doctor and pharmacist if you are allergic to tapentadol, or any other medications, or any of the ingredients in tapentadol tablets or extended-release tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor if you are taking the following medications or have stopped taking them within the past two weeks: monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), rasagiline (Azilect), selegiline (Emsam, Eldepryl, Zelapar), and tranylcypromine (Parnate). Also tell your doctor if any of these medications are prescribed for you during your treatment with tapentadol. Your doctor will probably tell you not to take tapentadol if you are taking one or more of these medications.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antihistamines (in cough, cold, and allergy medications); buprenorphine (Buprenex, Butrans, in Suboxone, in Zubsolv); butorphanol; cyclobenzaprine (Amrix); dextromethorphan (found in many cough medications; in Nuedexta); medications for irritable bowel disease, motion sickness, Parkinson's disease, ulcers, or urinary problems; lithium (Lithobid); medications for migraines such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, in Treximet), and zolmitriptan (Zomig); mirtazapine (Remeron); nalbuphine; pentazocine (Talwin); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); selective serotonin/norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), milnacipran (Savella), and venlafaxine (Effexor); tramadol (Conzip, Ultram, in Ultracet); trazodone; or tricyclic antidepressants ('mood elevators') such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor, Zonalon), imipramine (Surmontil, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil). Many other medications may also interact with tapentadol, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor what herbal products you are taking, especially St. John's wort and tryptophan.

  • tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or paralytic ileus (condition in which digested food does not move through the intestines). Your doctor may tell you not to take tapentadol.

  • tell your doctor if you have or have ever had a blockage in your stomach or intestines, any condition that causes difficulty urinating; or pancreas, gallbladder, kidney, thyroid, or liver disease.

  • tell your doctor if you are breastfeeding.

  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking tapentadol.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking tapentadol.

  • you should know that tapentadol may make you drowsy. Do not drive a car, operate machinery, or participate in any other possibly dangerous activities until you know how this medication affects you.

  • you should know that tapentadol may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

  • you should know that tapentadol may cause constipation. Talk to your doctor about changing your diet or using other medications to prevent or treat constipation while you are taking tapentadol.

Unless your doctor tells you otherwise, continue your normal diet.

If you are taking tapentadol tablets, your doctor will probably tell you to take the medication as needed. If your doctor has told you to take the tablets regularly, take the missed dose as soon as you remember it. Do not take a double dose to make up for a missed one.

If you are taking tapentadol extended-release capsules, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Tapentadol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • heartburn

    • stomach pain

    • dry mouth

    • excessive tiredness

    • anxiety

    • drowsiness

    • difficulty falling asleep or staying asleep

    • abnormal dreams

    • irritability

    • sudden feeling of warmth

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS or IMPORTANT WARNING sections, call your doctor immediately or get emergency medical treatment:

    • seizures

    • agitation, hallucinations (seeing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

    • nausea, vomiting, loss of appetite, weakness, or dizziness

    • inability to get or keep an erection

    • irregular menstruation

    • decreased sexual desire

    • rash

    • itching

    • hives

    • swelling of the eyes, face, lips, tongue, or throat

    • hoarseness

    • difficulty breathing or swallowing

    • chest pain

    • feeling lightheaded when you change positions

    • feeling faint

    • loss of consciousness

    • feeling overheated

    • heavy sweating

  • Tapentadol may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). You must immediately dispose of any medication that is outdated or no longer needed through a medicine take-back program. If you do not have a take-back program nearby or one that you can access promptly, flush any medication that is outdated or no longer needed down the toilet. Talk to your pharmacist about the proper disposal of your medication.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

While taking tapentadol, you should talk to your doctor about having a rescue medication called naloxone readily available (e.g., home, office). Naloxone is used to reverse the life-threatening effects of an overdose. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. Your doctor may also prescribe you naloxone if you are living in a household where there are small children or someone who has abused street or prescription drugs. You should make sure that you and your family members, caregivers, or the people who spend time with you know how to recognize an overdose, how to use naloxone, and what to do until emergency medical help arrives. Your doctor or pharmacist will show you and your family members how to use the medication. Ask your pharmacist for the instructions or visit the manufacturer's website to get the instructions. If symptoms of an overdose occur, a friend or family member should give the first dose of naloxone, call 911 immediately, and stay with you and watch you closely until emergency medical help arrives. Your symptoms may return within a few minutes after you receive naloxone. If your symptoms return, the person should give you another dose of naloxone. Additional doses may be given every 2 to 3 minutes, if symptoms return before medical help arrives.

Symptoms of overdose may include the following:

  • narrowing or widening of the pupils (dark circles in the eyes)

  • sleepiness

  • unable to respond or wake up

  • muscle weakness

  • cold, clammy skin

  • slow or shallow breathing

  • difficulty breathing

  • slowed heartbeat

Keep all appointments with your doctor and laboratory. Your doctor may order certain lab tests to check your body's response to tapentadol.

Before having any laboratory test (especially those that involve methylene blue), tell your doctor and the laboratory personnel that you are taking tapentadol.

This prescription is not refillable. If you continue to have pain after you finish the medication, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Montelukast Montelukast The metabolism of Tapentadol can be decreased when combined with Montelukast.
Leflunomide Leflunomide The metabolism of Tapentadol can be decreased when combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Tapentadol can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Tapentadol can be decreased when combined with Nevirapine.
Dolasetron Dolasetron Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dolasetron.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Tapentadol.
Candesartan Candesartan The metabolism of Tapentadol can be decreased when combined with Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Tapentadol.
Clopidogrel Clopidogrel Tapentadol can cause a decrease in the absorption of Clopidogrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Diphenoxylate Diphenoxylate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Diphenoxylate.
Fenofibrate Fenofibrate The metabolism of Tapentadol can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Guanfacine.
Magnesium Hydroxide Magnesium Hydroxide The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Tapentadol.
Magnesium Oxide Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Tapentadol.
Naratriptan Naratriptan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Naratriptan.
Paregoric Paregoric Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Morphine.
Penbutolol Penbutolol The metabolism of Tapentadol can be decreased when combined with Acebutolol.
Pentazocine Pentazocine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Tapentadol.
Potassium Potassium The therapeutic efficacy of Potassium cation can be decreased when used in combination with Tapentadol.
Psyllium Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Tapentadol.
Ranitidine Ranitidine The metabolism of Tapentadol can be decreased when combined with Ranitidine.
Reserpine Reserpine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Reserpine.
Rizatriptan Rizatriptan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Rizatriptan.
Sumatriptan Sumatriptan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Sumatriptan.
Tizanidine Tizanidine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Tizanidine.
Zolmitriptan Zolmitriptan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zolmitriptan.
Fluconazole Injection Fluconazole Injection The metabolism of Tapentadol can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Hydromorphone.
Meperidine Injection Meperidine Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Meperidine.
Metoclopramide Injection Metoclopramide Injection The therapeutic efficacy of Metoclopramide can be decreased when used in combination with Tapentadol.
Metronidazole Injection Metronidazole Injection The metabolism of Tapentadol can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Morphine.
Zidovudine Injection Zidovudine Injection The metabolism of Tapentadol can be decreased when combined with Zidovudine.
Altretamine Altretamine The risk or severity of adverse effects can be increased when Tapentadol is combined with Amphetamine.
Cyclosporine Cyclosporine The metabolism of Tapentadol can be decreased when combined with Cyclosporine.
Ondansetron Ondansetron Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ondansetron.
Granisetron Granisetron Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Granisetron.
Torsemide Torsemide The metabolism of Tapentadol can be decreased when combined with Torasemide.
Olanzapine Olanzapine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.
Alosetron Alosetron Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Alosetron.
Entacapone Entacapone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Entacapone.
Hydroxychloroquine Hydroxychloroquine The metabolism of Tapentadol can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam The metabolism of Tapentadol can be decreased when combined with Meloxicam.
Oxcarbazepine Oxcarbazepine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Oxcarbazepine.
Zaleplon Zaleplon Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Anakinra Anakinra The metabolism of Tapentadol can be increased when combined with Anakinra.
Desloratadine Desloratadine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Tapentadol.
Trimipramine Trimipramine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Tapentadol can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate The risk or severity of adverse effects can be increased when Tapentadol is combined with Glycopyrronium.
Modafinil Modafinil The metabolism of Tapentadol can be decreased when combined with Modafinil.
Epinephrine Injection Epinephrine Injection The metabolism of Tapentadol can be decreased when combined with Epinephrine.
Eplerenone Eplerenone The therapeutic efficacy of Eplerenone can be decreased when used in combination with Tapentadol.
Escitalopram Escitalopram Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Escitalopram.
Zonisamide Zonisamide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Tapentadol can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.
Atomoxetine Atomoxetine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Atomoxetine.
Dexmethylphenidate Dexmethylphenidate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dexmethylphenidate.
Atazanavir Atazanavir The metabolism of Tapentadol can be decreased when combined with Atazanavir.
Almotriptan Almotriptan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Almotriptan.
Eletriptan Eletriptan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Eletriptan.
Mefloquine Mefloquine The metabolism of Tapentadol can be decreased when combined with Mefloquine.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Tapentadol.
Rosuvastatin Rosuvastatin The metabolism of Tapentadol can be decreased when combined with Rosuvastatin.
Aprepitant Aprepitant The metabolism of Tapentadol can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The metabolism of Tapentadol can be decreased when combined with Tegaserod.
Frovatriptan Frovatriptan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Frovatriptan.
Progesterone Progesterone The metabolism of Tapentadol can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Tapentadol can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Tapentadol can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
Duloxetine Duloxetine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Trospium Trospium The risk or severity of adverse effects can be increased when Tapentadol is combined with Trospium.
Bosentan Bosentan The metabolism of Tapentadol can be increased when combined with Bosentan.
Cinacalcet Cinacalcet The metabolism of Tapentadol can be decreased when combined with Cinacalcet.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Tapentadol.
Eszopiclone Eszopiclone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.
Solifenacin Solifenacin The risk or severity of adverse effects can be increased when Tapentadol is combined with Solifenacin.
Voriconazole Voriconazole The metabolism of Tapentadol can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine The risk or severity of adverse effects can be increased when Tapentadol is combined with Amphetamine.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Tapentadol can be increased when combined with Peginterferon alfa-2b.
Sodium Oxybate Sodium Oxybate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Isocarboxazid Isocarboxazid The risk or severity of adverse effects can be increased when Tapentadol is combined with Isocarboxazid.
Ramelteon Ramelteon Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
Darifenacin Darifenacin The metabolism of Tapentadol can be decreased when combined with Darifenacin.
Fentanyl Fentanyl Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Pregabalin Pregabalin Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
Deferasirox Deferasirox The metabolism of Tapentadol can be decreased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Tapentadol can be decreased when combined with Tipranavir.
Felbamate Felbamate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Felbamate.
Ranolazine Ranolazine The serum concentration of Tapentadol can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Tapentadol can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of adverse effects can be increased when Tapentadol is combined with Rasagiline.
Imatinib Imatinib The metabolism of Tapentadol can be decreased when combined with Imatinib.
Gefitinib Gefitinib The metabolism of Tapentadol can be decreased when combined with Gefitinib.
Paliperidone Paliperidone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.
Bortezomib Bortezomib The metabolism of Tapentadol can be decreased when combined with Bortezomib.
Lubiprostone Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Tapentadol.
Primaquine Primaquine The metabolism of Tapentadol can be decreased when combined with Primaquine.
Dimenhydrinate Dimenhydrinate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dimenhydrinate.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may increase the analgesic activities of Tapentadol.
Nabilone Nabilone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.
Sorafenib Sorafenib The metabolism of Tapentadol can be decreased when combined with Sorafenib.
Dronabinol Dronabinol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.
Levocetirizine Levocetirizine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Tapentadol.
Armodafinil Armodafinil The metabolism of Tapentadol can be decreased when combined with Armodafinil.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Tapentadol.
Temsirolimus Temsirolimus The metabolism of Tapentadol can be decreased when combined with Temsirolimus.
Nilotinib Nilotinib The metabolism of Tapentadol can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Tapentadol can be decreased when combined with Bexarotene.
Desmopressin Desmopressin The risk or severity of hyponatremia can be increased when Tapentadol is combined with Desmopressin.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Botulinum toxin type A.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Botulinum Toxin Type B.
Etravirine Etravirine The metabolism of Tapentadol can be decreased when combined with Etravirine.
Desvenlafaxine Desvenlafaxine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Desvenlafaxine.
Cevimeline Cevimeline The metabolism of Cevimeline can be decreased when combined with Tapentadol.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Tapentadol.
Tretinoin Tretinoin The metabolism of Tapentadol can be decreased when combined with Tretinoin.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Tapentadol.
Certolizumab Injection Certolizumab Injection The metabolism of Tapentadol can be increased when combined with Certolizumab pegol.
Alvimopan Alvimopan The risk or severity of adverse effects can be increased when Tapentadol is combined with Alvimopan.
Methylnaltrexone Injection Methylnaltrexone Injection The therapeutic efficacy of Tapentadol can be decreased when used in combination with Methylnaltrexone.
Rufinamide Rufinamide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Rufinamide.
Midazolam Midazolam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Midazolam.
Naltrexone Injection Naltrexone Injection The risk or severity of adverse effects can be increased when Naltrexone is combined with Tapentadol.
Eltrombopag Eltrombopag The metabolism of Tapentadol can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Tapentadol.
Fesoterodine Fesoterodine The risk or severity of adverse effects can be increased when Tapentadol is combined with Fesoterodine.
Betaxolol Betaxolol The metabolism of Betaxolol can be decreased when combined with Tapentadol.
Iloperidone Iloperidone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Tapentadol.
Lacosamide Lacosamide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Everolimus Everolimus The metabolism of Tapentadol can be decreased when combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Tapentadol.
Dronedarone Dronedarone The metabolism of Tapentadol can be decreased when combined with Dronedarone.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Botulinum toxin type A.
Palonosetron Injection Palonosetron Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Palonosetron.
Golimumab Injection Golimumab Injection The metabolism of Tapentadol can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Tapentadol.
Asenapine Asenapine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Asenapine.
Vigabatrin Vigabatrin Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Vigabatrin.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Tapentadol.
Oxymorphone Oxymorphone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Oxymorphone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Tapentadol can be increased when combined with Tocilizumab.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Botulinum toxin type A.
Lurasidone Lurasidone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Tapentadol.
Vilazodone Vilazodone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Vilazodone.
Rilpivirine Rilpivirine The metabolism of Tapentadol can be decreased when combined with Rilpivirine.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Tapentadol can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Tapentadol can be decreased when combined with Abiraterone.
Ticagrelor Ticagrelor Ticagrelor can cause a decrease in the absorption of Tapentadol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Clobazam Clobazam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
Vemurafenib Vemurafenib The metabolism of Tapentadol can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Tapentadol can be decreased when combined with Vismodegib.
Cabergoline Cabergoline Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cabergoline.
Naloxone Injection Naloxone Injection The therapeutic efficacy of Tapentadol can be decreased when used in combination with Naloxone.
Ezogabine Ezogabine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
Enzalutamide Enzalutamide The metabolism of Tapentadol can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The metabolism of Mirabegron can be decreased when combined with Tapentadol.
Regorafenib Regorafenib The metabolism of Tapentadol can be decreased when combined with Regorafenib.
Linaclotide Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Tapentadol.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Tapentadol.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Tapentadol.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Tapentadol.
Pomalidomide Pomalidomide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Tapentadol.
Canagliflozin Canagliflozin The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Tapentadol.
Methazolamide Methazolamide The therapeutic efficacy of Methazolamide can be decreased when used in combination with Tapentadol.
Dabrafenib Dabrafenib The metabolism of Tapentadol can be increased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Tapentadol can be decreased when combined with Ospemifene.
Levomilnacipran Levomilnacipran Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Levomilnacipran.
Vortioxetine Vortioxetine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Perampanel Perampanel Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Tapentadol.
Ketorolac Injection Ketorolac Injection The metabolism of Tapentadol can be decreased when combined with Ketorolac.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Tapentadol.
Apremilast Apremilast The metabolism of Tapentadol can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Tapentadol can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Tapentadol can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Eslicarbazepine.
Testosterone Injection Testosterone Injection The metabolism of Tapentadol can be decreased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Tapentadol can be decreased when combined with Oritavancin.
Hydrocodone Hydrocodone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant Suvorexant Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Methamphetamine Methamphetamine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Metamfetamine.
Tasimelteon Tasimelteon Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
Secukinumab Injection Secukinumab Injection The metabolism of Tapentadol can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
Lenvatinib Lenvatinib The metabolism of Tapentadol can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Tapentadol can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Tapentadol can be decreased when combined with Panobinostat.
Haloperidol Injection Haloperidol Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Haloperidol.
Amiloride Amiloride The therapeutic efficacy of Amiloride can be decreased when used in combination with Tapentadol.
Flibanserin Flibanserin Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.
Rolapitant Rolapitant The metabolism of Tapentadol can be decreased when combined with Rolapitant.
Brexpiprazole Brexpiprazole Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.
Cariprazine Cariprazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cariprazine.
Eluxadoline Eluxadoline The risk or severity of constipation can be increased when Tapentadol is combined with Eluxadoline.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Tapentadol.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Tapentadol.
Brivaracetam Injection Brivaracetam Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Brivaracetam.
Cobicistat Cobicistat The metabolism of Tapentadol can be decreased when combined with Cobicistat.
Pimavanserin Pimavanserin Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Furosemide can be decreased when used in combination with Tapentadol.
Rucaparib Rucaparib The metabolism of Tapentadol can be decreased when combined with Rucaparib.
Doxepin (Insomnia) Doxepin (Insomnia) Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Plecanatide Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Tapentadol.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Tapentadol.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Tapentadol.
Safinamide Safinamide The risk or severity of adverse effects can be increased when Tapentadol is combined with Safinamide.
Naldemedine Naldemedine The therapeutic efficacy of Tapentadol can be decreased when used in combination with Naldemedine.
Midostaurin Midostaurin The metabolism of Tapentadol can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Tapentadol can be decreased when combined with Enasidenib.
Delafloxacin Delafloxacin The metabolism of Tapentadol can be increased when combined with Delafloxacin.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Tapentadol.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Tapentadol.
Ertugliflozin Ertugliflozin The therapeutic efficacy of Ertugliflozin can be decreased when used in combination with Tapentadol.
Buprenorphine Injection Buprenorphine Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide The metabolism of Tapentadol can be increased when combined with Apalutamide.
Avatrombopag Avatrombopag The metabolism of Tapentadol can be increased when combined with Avatrombopag.
Lofexidine Lofexidine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lofexidine.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Tapentadol.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Tapentadol.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Tapentadol.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Tapentadol.
Cannabidiol Cannabidiol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cannabidiol.
Dacomitinib Dacomitinib The metabolism of Tapentadol can be decreased when combined with Dacomitinib.
Stiripentol Stiripentol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.
Gilteritinib Gilteritinib The therapeutic efficacy of Tapentadol can be decreased when used in combination with Gilteritinib.
Rifamycin Rifamycin The metabolism of Tapentadol can be decreased when combined with Rifamycin.
Prucalopride Prucalopride The therapeutic efficacy of Prucalopride can be decreased when used in combination with Tapentadol.
Magnesium Citrate Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Tapentadol.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Tapentadol can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Tapentadol.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Tapentadol.
Alpelisib Alpelisib The serum concentration of Tapentadol can be decreased when it is combined with Alpelisib.
Brexanolone Injection Brexanolone Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Brexanolone.
Solriamfetol Solriamfetol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Solriamfetol.
Triclabendazole Triclabendazole The metabolism of Tapentadol can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Tapentadol.
Pitolisant Pitolisant The metabolism of Pitolisant can be decreased when combined with Tapentadol.
Fedratinib Fedratinib The metabolism of Tapentadol can be decreased when combined with Fedratinib.
Phenytoin Injection Phenytoin Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Tapentadol.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Tapentadol.
Lumateperone Lumateperone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lumateperone.
Lasmiditan Lasmiditan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lasmiditan.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Tapentadol.
Lemborexant Lemborexant Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Fenfluramine Fenfluramine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fenfluramine.
Pralsetinib Pralsetinib The metabolism of Tapentadol can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Tapentadol can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Drospirenone can be decreased when used in combination with Tapentadol.
Viloxazine Viloxazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Viloxazine.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Tapentadol.
Indomethacin Indomethacin The metabolism of Tapentadol can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The metabolism of Tapentadol can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Tapentadol can be decreased when combined with Naproxen.
Trazodone Trazodone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Hydroxyurea Hydroxyurea The metabolism of Tapentadol can be decreased when combined with Hydroxyurea.
Floxuridine Floxuridine The metabolism of Tapentadol can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.
Metaxalone Metaxalone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
Levorphanol Levorphanol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
Primidone Primidone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Primidone.
Methsuximide Methsuximide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Methsuximide.
Diethylpropion Diethylpropion Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Diethylpropion.
Chlorpromazine Chlorpromazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.
Diazepam Diazepam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Diazepam.
Oxazepam Oxazepam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Oxazepam.
Flurazepam Flurazepam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
Clorazepate Clorazepate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Clorazepic acid.
Lorazepam Lorazepam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
Amantadine Amantadine The risk or severity of adverse effects can be increased when Amantadine is combined with Tapentadol.
Codeine Codeine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Codeine.
Meprobamate Meprobamate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Meprobamate.
Chlordiazepoxide Chlordiazepoxide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
Bromocriptine Bromocriptine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Bromocriptine.
Tranylcypromine Tranylcypromine The risk or severity of adverse effects can be increased when Tapentadol is combined with Tranylcypromine.
Phenelzine Phenelzine The risk or severity of adverse effects can be increased when Tapentadol is combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Tapentadol is combined with Procarbazine.
Ergoloid Mesylates Ergoloid Mesylates Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ergoloid mesylate.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.
Prochlorperazine Prochlorperazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Prochlorperazine.
Thioridazine Thioridazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Thioridazine.
Trifluoperazine Trifluoperazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Trifluoperazine.
Dapsone Dapsone The metabolism of Tapentadol can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Tapentadol can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Tapentadol.
Oxybutynin Oxybutynin The risk or severity of adverse effects can be increased when Tapentadol is combined with Oxybutynin.
Benztropine Benztropine The risk or severity of adverse effects can be increased when Tapentadol is combined with Benzatropine.
Maprotiline Maprotiline Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Ibuprofen Ibuprofen The metabolism of Tapentadol can be decreased when combined with Ibuprofen.
Trihexyphenidyl Trihexyphenidyl The risk or severity of adverse effects can be increased when Tapentadol is combined with Trihexyphenidyl.
Orphenadrine Orphenadrine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Perphenazine.
Fluphenazine Fluphenazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fluphenazine.
Phentermine Phentermine Phentermine may increase the analgesic activities of Tapentadol.
Amoxapine Amoxapine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Doxorubicin Doxorubicin The metabolism of Tapentadol can be decreased when combined with Doxorubicin.
Carbamazepine Carbamazepine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Carbamazepine.
Molindone Molindone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Molindone.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Tapentadol.
Cimetidine Cimetidine The metabolism of Tapentadol can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Warfarin can be decreased when combined with Tapentadol.
Clonazepam Clonazepam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Tapentadol.
Promethazine Promethazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
Loxapine Loxapine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Loxapine.
Chloroquine Chloroquine The metabolism of Tapentadol can be decreased when combined with Chloroquine.
Quinine Quinine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Quinine.
Ethosuximide Ethosuximide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ethosuximide.
Triamterene Triamterene The therapeutic efficacy of Triamterene can be decreased when used in combination with Tapentadol.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Tapentadol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Tapentadol can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Tapentadol.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tapentadol.
Metolazone Metolazone The therapeutic efficacy of Metolazone can be decreased when used in combination with Tapentadol.
Isosorbide Isosorbide The therapeutic efficacy of Isosorbide can be decreased when used in combination with Tapentadol.
Secobarbital Secobarbital Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Secobarbital.
Desipramine Desipramine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Tapentadol.
Imipramine Imipramine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
Probenecid Probenecid The metabolism of Tapentadol can be decreased when combined with Probenecid.
Quinidine Quinidine The risk or severity of adverse effects can be increased when Tapentadol is combined with Quinidine.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Tapentadol.
Isoniazid Isoniazid The metabolism of Tapentadol can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Tapentadol can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of adverse effects can be increased when Tapentadol is combined with Disopyramide.
Valproic Acid Valproic Acid Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Valproic acid.
Tamoxifen Tamoxifen The metabolism of Tapentadol can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
Methimazole Methimazole The metabolism of Tapentadol can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide The metabolism of Tapentadol can be decreased when combined with Chlorpropamide.
Tolbutamide Tolbutamide The metabolism of Tapentadol can be decreased when combined with Tolbutamide.
Tolazamide Tolazamide The metabolism of Tapentadol can be decreased when combined with Tolazamide.
Dextromethorphan Dextromethorphan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dextromethorphan.
Cyclobenzaprine Cyclobenzaprine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
Niacin Niacin The metabolism of Tapentadol can be decreased when combined with Niacin.
Baclofen Baclofen Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Baclofen.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.
Cyproheptadine Cyproheptadine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine Clemastine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Clemastine.
Chlorpheniramine Chlorpheniramine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlorpheniramine.
Brompheniramine Brompheniramine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.
Meclizine Meclizine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Tapentadol.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Tapentadol.
Dantrolene Dantrolene Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dantrolene.
Chlorzoxazone Chlorzoxazone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.
Carisoprodol Carisoprodol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Carisoprodol.
Methocarbamol Methocarbamol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Tapentadol.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may increase the analgesic activities of Tapentadol.
Nortriptyline Nortriptyline Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
Spironolactone Spironolactone The therapeutic efficacy of Spironolactone can be decreased when used in combination with Tapentadol.
Nadolol Nadolol The metabolism of Nadolol can be decreased when combined with Tapentadol.
Butorphanol Injection Butorphanol Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Butorphanol.
Nalbuphine Injection Nalbuphine Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Nalbuphine.
Trimethobenzamide Trimethobenzamide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Trimethobenzamide.
Flavoxate Flavoxate The risk or severity of adverse effects can be increased when Tapentadol is combined with Flavoxate.
Fluorouracil Injection Fluorouracil Injection The metabolism of Tapentadol can be decreased when combined with Fluorouracil.
Acetazolamide Acetazolamide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Acetazolamide.
Ketoconazole Ketoconazole The metabolism of Tapentadol can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pyrantel.
Vinblastine Vinblastine The metabolism of Tapentadol can be decreased when combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Tapentadol.
Metoprolol Metoprolol The metabolism of Tapentadol can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.
Thiothixene Thiothixene Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Thiothixene.
Aspirin Aspirin The metabolism of Tapentadol can be decreased when combined with Acetylsalicylic acid.
Alprazolam Alprazolam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
Temazepam Temazepam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
Triazolam Triazolam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
Dicyclomine Dicyclomine The risk or severity of adverse effects can be increased when Tapentadol is combined with Dicyclomine.
Hyoscyamine Hyoscyamine The risk or severity of adverse effects can be increased when Tapentadol is combined with Hyoscyamine.
Propantheline Propantheline The risk or severity of adverse effects can be increased when Tapentadol is combined with Propantheline.
Trimethoprim Trimethoprim The metabolism of Tapentadol can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Tapentadol.
Nifedipine Nifedipine The metabolism of Nifedipine can be decreased when combined with Tapentadol.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Tapentadol.
Verapamil Verapamil The metabolism of Tapentadol can be decreased when combined with Verapamil.
Atenolol Atenolol The metabolism of Atenolol can be decreased when combined with Tapentadol.
Pindolol Pindolol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pindolol.
Cisplatin Injection Cisplatin Injection The metabolism of Tapentadol can be decreased when combined with Cisplatin.
Diflunisal Diflunisal The metabolism of Tapentadol can be decreased when combined with Diflunisal.
Piroxicam Piroxicam The metabolism of Tapentadol can be decreased when combined with Piroxicam.
Bumetanide Bumetanide The therapeutic efficacy of Bumetanide can be decreased when used in combination with Tapentadol.
Glyburide Glyburide The metabolism of Tapentadol can be decreased when combined with Glyburide.
Glipizide Glipizide The metabolism of Tapentadol can be decreased when combined with Glipizide.
Indapamide Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Tapentadol.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Tapentadol.
Labetalol Labetalol The metabolism of Tapentadol can be decreased when combined with Labetalol.
Gemfibrozil Gemfibrozil The metabolism of Tapentadol can be decreased when combined with Gemfibrozil.
Pimozide Pimozide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pimozide.
Flurbiprofen Flurbiprofen The metabolism of Tapentadol can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Tapentadol can be decreased when combined with Amiodarone.
Buspirone Buspirone The metabolism of Buspirone can be decreased when combined with Tapentadol.
Lovastatin Lovastatin The metabolism of Tapentadol can be decreased when combined with Lovastatin.
Diclofenac Diclofenac The metabolism of Tapentadol can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fluoxetine.
Clozapine Clozapine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Clozapine.
Estazolam Estazolam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Estazolam.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Tapentadol.
Etodolac Etodolac The metabolism of Tapentadol can be decreased when combined with Etodolac.
Felodipine Felodipine The metabolism of Tapentadol can be decreased when combined with Felodipine.
Nabumetone Nabumetone The metabolism of Tapentadol can be decreased when combined with Nabumetone.
Simvastatin Simvastatin The metabolism of Tapentadol can be decreased when combined with Simvastatin.
Teniposide Injection Teniposide Injection The metabolism of Tapentadol can be decreased when combined with Teniposide.
Atovaquone Atovaquone The metabolism of Tapentadol can be decreased when combined with Atovaquone.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Tapentadol.
Zolpidem Zolpidem Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Tapentadol.
Omeprazole Omeprazole The metabolism of Tapentadol can be decreased when combined with Omeprazole.
Cisapride Cisapride Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cisapride.
Gabapentin Gabapentin Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.
Fluvastatin Fluvastatin The metabolism of Tapentadol can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Venlafaxine.
Fluvoxamine Fluvoxamine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fluvoxamine.
Nefazodone Nefazodone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Nefazodone.
Lamotrigine Lamotrigine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
Losartan Losartan The metabolism of Tapentadol can be decreased when combined with Losartan.
Tramadol Tramadol The risk or severity of serotonin syndrome can be increased when Tapentadol is combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Tapentadol can be decreased when combined with Vinorelbine.
Lansoprazole Lansoprazole The metabolism of Tapentadol can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Tapentadol can be decreased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Tapentadol can be decreased when combined with Nicardipine.
Bupropion Bupropion Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Bupropion.
Ticlopidine Ticlopidine The metabolism of Tapentadol can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Tapentadol can be decreased when combined with Saquinavir.
Riluzole Riluzole Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Riluzole.
Glimepiride Glimepiride The metabolism of Tapentadol can be decreased when combined with Glimepiride.
Ritonavir Ritonavir The metabolism of Tapentadol can be decreased when combined with Ritonavir.
Clomipramine Clomipramine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Clomipramine.
Zafirlukast Zafirlukast The metabolism of Tapentadol can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine Tapentadol may increase the serotonergic activities of Mirtazapine.
Topiramate Topiramate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Topiramate.
Zileuton Zileuton The metabolism of Tapentadol can be decreased when combined with Zileuton.
Valsartan Valsartan The metabolism of Tapentadol can be decreased when combined with Valsartan.
Pramipexole Pramipexole Tapentadol may increase the sedative activities of Pramipexole.
Donepezil Donepezil Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Donepezil.
Nelfinavir Nelfinavir The metabolism of Tapentadol can be decreased when combined with Nelfinavir.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Tapentadol.
Nilutamide Nilutamide The metabolism of Tapentadol can be decreased when combined with Nilutamide.
Selegiline Selegiline The risk or severity of adverse effects can be increased when Tapentadol is combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Tapentadol can be decreased when combined with Bicalutamide.
Sertraline Sertraline Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Propafenone Propafenone The metabolism of Tapentadol can be decreased when combined with Propafenone.
Irbesartan Irbesartan The metabolism of Tapentadol can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Tapentadol.
Ropinirole Ropinirole Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ropinirole.
Quetiapine Quetiapine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
Cetirizine Cetirizine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cetirizine.
Paroxetine Paroxetine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Paroxetine.
Tolcapone Tolcapone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.
Citalopram Citalopram Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Citalopram.
Capecitabine Capecitabine The metabolism of Tapentadol can be decreased when combined with Capecitabine.
Efavirenz Efavirenz Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Efavirenz.
Sildenafil Sildenafil The metabolism of Sildenafil can be decreased when combined with Tapentadol.
Celecoxib Celecoxib The metabolism of Tapentadol can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Tapentadol can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The risk or severity of adverse effects can be increased when Tapentadol is combined with Tolterodine.
Thalidomide Thalidomide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Tapentadol.
Galantamine Galantamine The metabolism of Galantamine can be decreased when combined with Tapentadol.
Levetiracetam Levetiracetam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
Rabeprazole Rabeprazole The metabolism of Tapentadol can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Tapentadol can be decreased when combined with Terbinafine.

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