Tapentadol

Tapentadol tablets are used to treat moderate to severe acute pain (pain that begins suddenly, has a specific cause, and is expected to go away when the cause of the pain is healed). Tapentadol extended-release tablets are used to treat severe neuropathic pain (pain caused by nerve damage) in people who have diabetes. Tapentadol extended-release tablets are only used to treat people who are expected to need medication around-the-clock to relieve pain that cannot be controlled by the use of other pain medications. Tapentadol is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

Tapentadol comes as a tablet and an extended-release (long acting) tablet to take by mouth. The tablets are usually taken with or without food every 4 to 6 hours as needed. If you are taking tapentadol tablets, your doctor may tell you that you may take a second dose as soon as 1 hour after the first dose on your first day of treatment if needed to treat your pain. Do not take extra doses at any other time during your treatment and do not ever take extra doses of the extended-release tablets. The extended-release tablets are taken once every 12 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tapentadol exactly as directed.

If you are taking the extended-release tablets, swallow them one at a time with plenty of water. Swallow each tablet right after you put it in your mouth.

Your doctor will probably start you on a low dose of tapentadol and gradually increase your dose until your pain is controlled. Your doctor may adjust your dose at any time during your treatment if your pain is not controlled. If you feel that your pain is not controlled, call your doctor. Do not change the dose of your medication without talking to your doctor.

After you take tapentadol for a period of time, your body may become used to the medication. If this happens, your doctor may need to increase your dose of medication to control your pain. Talk to your doctor about how you are feeling during your treatment with tapentadol.

Do not stop taking tapentadol without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking tapentadol, you may experience withdrawal symptoms such as restlessness; anxiety; irritability; teary eyes; yawning; chills; sweating; difficulty falling asleep or staying asleep; shivering; uncontrollable shaking of a part of your body; muscle, back, or joint pain; weakness; nausea; vomiting; diarrhea; stomach cramps; loss of appetite; runny nose, sneezing, or coughing; hair on your skin standing on end; fast breathing; fast heartbeat; widening of the pupils (black circles in the middle of the eyes); or hallucinations (seeing things or hearing voices that do not exist).

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking tapentadol,

• tell your doctor and pharmacist if you are allergic to tapentadol, or any other medications, or any of the ingredients in tapentadol tablets or extended-release tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

• tell your doctor if you are taking the following medications or have stopped taking them within the past two weeks: monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), rasagiline (Azilect), selegiline (Emsam, Eldepryl, Zelapar), and tranylcypromine (Parnate). Also tell your doctor if any of these medications are prescribed for you during your treatment with tapentadol. Your doctor will probably tell you not to take tapentadol if you are taking one or more of these medications.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antihistamines (in cough, cold, and allergy medications); buprenorphine (Buprenex, Butrans, in Suboxone, in Zubsolv); butorphanol; cyclobenzaprine (Amrix); dextromethorphan (found in many cough medications; in Nuedexta); medications for irritable bowel disease, motion sickness, Parkinson's disease, ulcers, or urinary problems; lithium (Lithobid); medications for migraines such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, in Treximet), and zolmitriptan (Zomig); mirtazapine (Remeron); nalbuphine; pentazocine (Talwin); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); selective serotonin/norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), milnacipran (Savella), and venlafaxine (Effexor); tramadol (Conzip, Ultram, in Ultracet); trazodone; or tricyclic antidepressants ('mood elevators') such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor, Zonalon), imipramine (Surmontil, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil). Many other medications may also interact with tapentadol, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor what herbal products you are taking, especially St. John's wort and tryptophan.

• tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or paralytic ileus (condition in which digested food does not move through the intestines). Your doctor may tell you not to take tapentadol.

• tell your doctor if you have or have ever had a blockage in your stomach or intestines, any condition that causes difficulty urinating; or pancreas, gallbladder, kidney, thyroid, or liver disease.

• tell your doctor if you are breastfeeding.

• you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking tapentadol.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking tapentadol.

• you should know that tapentadol may make you drowsy. Do not drive a car, operate machinery, or participate in any other possibly dangerous activities until you know how this medication affects you.

• you should know that tapentadol may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

• you should know that tapentadol may cause constipation. Talk to your doctor about changing your diet or using other medications to prevent or treat constipation while you are taking tapentadol.

Unless your doctor tells you otherwise, continue your normal diet.

If you are taking tapentadol tablets, your doctor will probably tell you to take the medication as needed. If your doctor has told you to take the tablets regularly, take the missed dose as soon as you remember it. Do not take a double dose to make up for a missed one.

If you are taking tapentadol extended-release capsules, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Tapentadol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache

  • heartburn

  • stomach pain

  • dry mouth

  • excessive tiredness

  • anxiety

  • drowsiness

  • difficulty falling asleep or staying asleep

  • abnormal dreams

  • irritability

  • sudden feeling of warmth

• Some side effects can be serious. If you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS or IMPORTANT WARNING sections, call your doctor immediately or get emergency medical treatment:

  • seizures

  • agitation, hallucinations (seeing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

  • nausea, vomiting, loss of appetite, weakness, or dizziness

  • inability to get or keep an erection

  • irregular menstruation

  • decreased sexual desire

  • rash

  • itching

  • hives

  • swelling of the eyes, face, lips, tongue, or throat

  • hoarseness

  • difficulty breathing or swallowing

  • chest pain

  • feeling lightheaded when you change positions

  • feeling faint

  • loss of consciousness

  • feeling overheated

  • heavy sweating

• Tapentadol may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). You must immediately dispose of any medication that is outdated or no longer needed through a medicine take-back program. If you do not have a take-back program nearby or one that you can access promptly, flush any medication that is outdated or no longer needed down the toilet. Talk to your pharmacist about the proper disposal of your medication.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

While taking tapentadol, you should talk to your doctor about having a rescue medication called naloxone readily available (e.g., home, office). Naloxone is used to reverse the life-threatening effects of an overdose. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. Your doctor may also prescribe you naloxone if you are living in a household where there are small children or someone who has abused street or prescription drugs. You should make sure that you and your family members, caregivers, or the people who spend time with you know how to recognize an overdose, how to use naloxone, and what to do until emergency medical help arrives. Your doctor or pharmacist will show you and your family members how to use the medication. Ask your pharmacist for the instructions or visit the manufacturer's website to get the instructions. If symptoms of an overdose occur, a friend or family member should give the first dose of naloxone, call 911 immediately, and stay with you and watch you closely until emergency medical help arrives. Your symptoms may return within a few minutes after you receive naloxone. If your symptoms return, the person should give you another dose of naloxone. Additional doses may be given every 2 to 3 minutes, if symptoms return before medical help arrives.

Symptoms of overdose may include the following:

• narrowing or widening of the pupils (dark circles in the eyes)

• sleepiness

• unable to respond or wake up

• muscle weakness

• cold, clammy skin

• slow or shallow breathing

• difficulty breathing

• slowed heartbeat

Keep all appointments with your doctor and laboratory. Your doctor may order certain lab tests to check your body's response to tapentadol.

Before having any laboratory test (especially those that involve methylene blue), tell your doctor and the laboratory personnel that you are taking tapentadol.

This prescription is not refillable. If you continue to have pain after you finish the medication, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Montelukast	Montelukast The metabolism of Tapentadol can be decreased when combined with Montelukast.
Leflunomide	Leflunomide The metabolism of Tapentadol can be decreased when combined with Leflunomide.
Delavirdine	Delavirdine The metabolism of Tapentadol can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Tapentadol can be decreased when combined with Nevirapine.
Dolasetron	Dolasetron Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dolasetron.
Bisacodyl	Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Tapentadol.
Candesartan	Candesartan The metabolism of Tapentadol can be decreased when combined with Candesartan.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Tapentadol.
Clopidogrel	Clopidogrel Tapentadol can cause a decrease in the absorption of Clopidogrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Diphenoxylate	Diphenoxylate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Diphenoxylate.
Fenofibrate	Fenofibrate The metabolism of Tapentadol can be decreased when combined with Fenofibrate.
Guanfacine	Guanfacine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Guanfacine.
Magnesium Hydroxide	Magnesium Hydroxide The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Tapentadol.
Magnesium Oxide	Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Tapentadol.
Naratriptan	Naratriptan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Naratriptan.
Paregoric	Paregoric Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Morphine.
Penbutolol	Penbutolol The metabolism of Tapentadol can be decreased when combined with Acebutolol.
Pentazocine	Pentazocine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES)	Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Tapentadol.
Potassium	Potassium The therapeutic efficacy of Potassium cation can be decreased when used in combination with Tapentadol.
Psyllium	Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Tapentadol.
Ranitidine	Ranitidine The metabolism of Tapentadol can be decreased when combined with Ranitidine.
Reserpine	Reserpine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Reserpine.
Rizatriptan	Rizatriptan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Rizatriptan.
Sumatriptan	Sumatriptan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Sumatriptan.
Tizanidine	Tizanidine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Tizanidine.
Zolmitriptan	Zolmitriptan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zolmitriptan.
Fluconazole Injection	Fluconazole Injection The metabolism of Tapentadol can be decreased when combined with Fluconazole.
Hydromorphone Injection	Hydromorphone Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Hydromorphone.
Meperidine Injection	Meperidine Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Meperidine.
Metoclopramide Injection	Metoclopramide Injection The therapeutic efficacy of Metoclopramide can be decreased when used in combination with Tapentadol.
Metronidazole Injection	Metronidazole Injection The metabolism of Tapentadol can be decreased when combined with Metronidazole.
Morphine Injection	Morphine Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Morphine.
Zidovudine Injection	Zidovudine Injection The metabolism of Tapentadol can be decreased when combined with Zidovudine.
Altretamine	Altretamine The risk or severity of adverse effects can be increased when Tapentadol is combined with Amphetamine.
Cyclosporine	Cyclosporine The metabolism of Tapentadol can be decreased when combined with Cyclosporine.
Ondansetron	Ondansetron Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ondansetron.
Granisetron	Granisetron Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Granisetron.
Torsemide	Torsemide The metabolism of Tapentadol can be decreased when combined with Torasemide.
Olanzapine	Olanzapine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.
Alosetron	Alosetron Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Alosetron.
Entacapone	Entacapone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Entacapone.
Hydroxychloroquine	Hydroxychloroquine The metabolism of Tapentadol can be decreased when combined with Hydroxychloroquine.
Meloxicam	Meloxicam The metabolism of Tapentadol can be decreased when combined with Meloxicam.
Oxcarbazepine	Oxcarbazepine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Oxcarbazepine.
Zaleplon	Zaleplon Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Anakinra	Anakinra The metabolism of Tapentadol can be increased when combined with Anakinra.
Desloratadine	Desloratadine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.
Linezolid	Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Tapentadol.
Trimipramine	Trimipramine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
Etanercept Injection	Etanercept Injection The metabolism of Tapentadol can be increased when combined with Etanercept.
Glycopyrrolate	Glycopyrrolate The risk or severity of adverse effects can be increased when Tapentadol is combined with Glycopyrronium.
Modafinil	Modafinil The metabolism of Tapentadol can be decreased when combined with Modafinil.
Epinephrine Injection	Epinephrine Injection The metabolism of Tapentadol can be decreased when combined with Epinephrine.
Eplerenone	Eplerenone The therapeutic efficacy of Eplerenone can be decreased when used in combination with Tapentadol.
Escitalopram	Escitalopram Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Escitalopram.
Zonisamide	Zonisamide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
Adalimumab Injection	Adalimumab Injection The metabolism of Tapentadol can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.
Atomoxetine	Atomoxetine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Atomoxetine.
Dexmethylphenidate	Dexmethylphenidate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dexmethylphenidate.
Atazanavir	Atazanavir The metabolism of Tapentadol can be decreased when combined with Atazanavir.
Almotriptan	Almotriptan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Almotriptan.
Eletriptan	Eletriptan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Eletriptan.
Mefloquine	Mefloquine The metabolism of Tapentadol can be decreased when combined with Mefloquine.
Polyethylene Glycol 3350	Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Tapentadol.
Rosuvastatin	Rosuvastatin The metabolism of Tapentadol can be decreased when combined with Rosuvastatin.
Aprepitant	Aprepitant The metabolism of Tapentadol can be decreased when combined with Aprepitant.
Tegaserod	Tegaserod The metabolism of Tapentadol can be decreased when combined with Tegaserod.
Frovatriptan	Frovatriptan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Frovatriptan.
Progesterone	Progesterone The metabolism of Tapentadol can be decreased when combined with Progesterone.
Apomorphine Injection	Apomorphine Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Apomorphine.
Infliximab Injection	Infliximab Injection The metabolism of Tapentadol can be increased when combined with Infliximab.
Oxandrolone	Oxandrolone The metabolism of Tapentadol can be decreased when combined with Oxandrolone.
Protriptyline	Protriptyline Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
Duloxetine	Duloxetine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Trospium	Trospium The risk or severity of adverse effects can be increased when Tapentadol is combined with Trospium.
Bosentan	Bosentan The metabolism of Tapentadol can be increased when combined with Bosentan.
Cinacalcet	Cinacalcet The metabolism of Tapentadol can be decreased when combined with Cinacalcet.
Erlotinib	Erlotinib The metabolism of Erlotinib can be decreased when combined with Tapentadol.
Eszopiclone	Eszopiclone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.
Solifenacin	Solifenacin The risk or severity of adverse effects can be increased when Tapentadol is combined with Solifenacin.
Voriconazole	Voriconazole The metabolism of Tapentadol can be decreased when combined with Voriconazole.
Dextroamphetamine	Dextroamphetamine The risk or severity of adverse effects can be increased when Tapentadol is combined with Amphetamine.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The metabolism of Tapentadol can be increased when combined with Peginterferon alfa-2b.
Sodium Oxybate	Sodium Oxybate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Isocarboxazid	Isocarboxazid The risk or severity of adverse effects can be increased when Tapentadol is combined with Isocarboxazid.
Ramelteon	Ramelteon Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
Darifenacin	Darifenacin The metabolism of Tapentadol can be decreased when combined with Darifenacin.
Fentanyl	Fentanyl Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
Pregabalin	Pregabalin Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
Deferasirox	Deferasirox The metabolism of Tapentadol can be decreased when combined with Deferasirox.
Tipranavir	Tipranavir The metabolism of Tapentadol can be decreased when combined with Tipranavir.
Felbamate	Felbamate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Felbamate.
Ranolazine	Ranolazine The serum concentration of Tapentadol can be increased when it is combined with Ranolazine.
Abatacept Injection	Abatacept Injection The metabolism of Tapentadol can be increased when combined with Abatacept.
Rasagiline	Rasagiline The risk or severity of adverse effects can be increased when Tapentadol is combined with Rasagiline.
Imatinib	Imatinib The metabolism of Tapentadol can be decreased when combined with Imatinib.
Gefitinib	Gefitinib The metabolism of Tapentadol can be decreased when combined with Gefitinib.
Paliperidone	Paliperidone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.
Bortezomib	Bortezomib The metabolism of Tapentadol can be decreased when combined with Bortezomib.
Lubiprostone	Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Tapentadol.
Primaquine	Primaquine The metabolism of Tapentadol can be decreased when combined with Primaquine.
Dimenhydrinate	Dimenhydrinate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dimenhydrinate.
Lisdexamfetamine	Lisdexamfetamine Lisdexamfetamine may increase the analgesic activities of Tapentadol.
Nabilone	Nabilone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.
Sorafenib	Sorafenib The metabolism of Tapentadol can be decreased when combined with Sorafenib.
Dronabinol	Dronabinol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dronabinol.
Levocetirizine	Levocetirizine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.
Mexiletine	Mexiletine The metabolism of Mexiletine can be decreased when combined with Tapentadol.
Armodafinil	Armodafinil The metabolism of Tapentadol can be decreased when combined with Armodafinil.
Paclitaxel (with polyoxyethylated castor oil) Injection	Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Tapentadol.
Temsirolimus	Temsirolimus The metabolism of Tapentadol can be decreased when combined with Temsirolimus.
Nilotinib	Nilotinib The metabolism of Tapentadol can be decreased when combined with Nilotinib.
Bexarotene	Bexarotene The metabolism of Tapentadol can be decreased when combined with Bexarotene.
Desmopressin	Desmopressin The risk or severity of hyponatremia can be increased when Tapentadol is combined with Desmopressin.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Botulinum toxin type A.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Botulinum Toxin Type B.
Etravirine	Etravirine The metabolism of Tapentadol can be decreased when combined with Etravirine.
Desvenlafaxine	Desvenlafaxine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Desvenlafaxine.
Cevimeline	Cevimeline The metabolism of Cevimeline can be decreased when combined with Tapentadol.
Nebivolol	Nebivolol The metabolism of Nebivolol can be decreased when combined with Tapentadol.
Tretinoin	Tretinoin The metabolism of Tapentadol can be decreased when combined with Tretinoin.
Flecainide	Flecainide The metabolism of Flecainide can be decreased when combined with Tapentadol.
Certolizumab Injection	Certolizumab Injection The metabolism of Tapentadol can be increased when combined with Certolizumab pegol.
Alvimopan	Alvimopan The risk or severity of adverse effects can be increased when Tapentadol is combined with Alvimopan.
Methylnaltrexone Injection	Methylnaltrexone Injection The therapeutic efficacy of Tapentadol can be decreased when used in combination with Methylnaltrexone.
Rufinamide	Rufinamide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Rufinamide.
Midazolam	Midazolam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Midazolam.
Naltrexone Injection	Naltrexone Injection The risk or severity of adverse effects can be increased when Naltrexone is combined with Tapentadol.
Eltrombopag	Eltrombopag The metabolism of Tapentadol can be decreased when combined with Eltrombopag.
Milnacipran	Milnacipran Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Milnacipran.
Sodium Phosphate	Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Tapentadol.
Fesoterodine	Fesoterodine The risk or severity of adverse effects can be increased when Tapentadol is combined with Fesoterodine.
Betaxolol	Betaxolol The metabolism of Betaxolol can be decreased when combined with Tapentadol.
Iloperidone	Iloperidone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.
Prasugrel	Prasugrel The metabolism of Prasugrel can be decreased when combined with Tapentadol.
Lacosamide	Lacosamide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Everolimus	Everolimus The metabolism of Tapentadol can be decreased when combined with Everolimus.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Tapentadol.
Dronedarone	Dronedarone The metabolism of Tapentadol can be decreased when combined with Dronedarone.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Botulinum toxin type A.
Palonosetron Injection	Palonosetron Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Palonosetron.
Golimumab Injection	Golimumab Injection The metabolism of Tapentadol can be increased when combined with Golimumab.
Pazopanib	Pazopanib The metabolism of Pazopanib can be decreased when combined with Tapentadol.
Asenapine	Asenapine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Asenapine.
Vigabatrin	Vigabatrin Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Vigabatrin.
Pitavastatin	Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Tapentadol.
Oxymorphone	Oxymorphone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Oxymorphone.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Tapentadol can be increased when combined with Tocilizumab.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Botulinum toxin type A.
Lurasidone	Lurasidone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Tapentadol.
Vilazodone	Vilazodone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Vilazodone.
Rilpivirine	Rilpivirine The metabolism of Tapentadol can be decreased when combined with Rilpivirine.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Tapentadol can be decreased when combined with Cyclophosphamide.
Abiraterone	Abiraterone The metabolism of Tapentadol can be decreased when combined with Abiraterone.
Ticagrelor	Ticagrelor Ticagrelor can cause a decrease in the absorption of Tapentadol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Clobazam	Clobazam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
Vemurafenib	Vemurafenib The metabolism of Tapentadol can be decreased when combined with Vemurafenib.
Vismodegib	Vismodegib The metabolism of Tapentadol can be decreased when combined with Vismodegib.
Cabergoline	Cabergoline Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cabergoline.
Naloxone Injection	Naloxone Injection The therapeutic efficacy of Tapentadol can be decreased when used in combination with Naloxone.
Ezogabine	Ezogabine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
Enzalutamide	Enzalutamide The metabolism of Tapentadol can be increased when combined with Enzalutamide.
Mirabegron	Mirabegron The metabolism of Mirabegron can be decreased when combined with Tapentadol.
Regorafenib	Regorafenib The metabolism of Tapentadol can be decreased when combined with Regorafenib.
Linaclotide	Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Tapentadol.
Cabozantinib (thyroid cancer)	Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Tapentadol.
Alogliptin	Alogliptin The metabolism of Alogliptin can be decreased when combined with Tapentadol.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Tapentadol.
Pomalidomide	Pomalidomide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.
Apixaban	Apixaban The metabolism of Apixaban can be decreased when combined with Tapentadol.
Canagliflozin	Canagliflozin The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Tapentadol.
Methazolamide	Methazolamide The therapeutic efficacy of Methazolamide can be decreased when used in combination with Tapentadol.
Dabrafenib	Dabrafenib The metabolism of Tapentadol can be increased when combined with Dabrafenib.
Ospemifene	Ospemifene The metabolism of Tapentadol can be decreased when combined with Ospemifene.
Levomilnacipran	Levomilnacipran Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Levomilnacipran.
Vortioxetine	Vortioxetine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Perampanel	Perampanel Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Tapentadol.
Ketorolac Injection	Ketorolac Injection The metabolism of Tapentadol can be decreased when combined with Ketorolac.
Dapagliflozin	Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Tapentadol.
Apremilast	Apremilast The metabolism of Tapentadol can be increased when combined with Apremilast.
Ceritinib	Ceritinib The metabolism of Tapentadol can be decreased when combined with Ceritinib.
Siltuximab Injection	Siltuximab Injection The metabolism of Tapentadol can be increased when combined with Siltuximab.
Eslicarbazepine	Eslicarbazepine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Eslicarbazepine.
Testosterone Injection	Testosterone Injection The metabolism of Tapentadol can be decreased when combined with Testosterone.
Oritavancin Injection	Oritavancin Injection The metabolism of Tapentadol can be decreased when combined with Oritavancin.
Hydrocodone	Hydrocodone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant	Suvorexant Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Methamphetamine	Methamphetamine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Metamfetamine.
Tasimelteon	Tasimelteon Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
Secukinumab Injection	Secukinumab Injection The metabolism of Tapentadol can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
Lenvatinib	Lenvatinib The metabolism of Tapentadol can be decreased when combined with Lenvatinib.
Naloxegol	Naloxegol The metabolism of Tapentadol can be decreased when combined with Naloxegol.
Panobinostat	Panobinostat The metabolism of Tapentadol can be decreased when combined with Panobinostat.
Haloperidol Injection	Haloperidol Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Haloperidol.
Amiloride	Amiloride The therapeutic efficacy of Amiloride can be decreased when used in combination with Tapentadol.
Flibanserin	Flibanserin Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.
Rolapitant	Rolapitant The metabolism of Tapentadol can be decreased when combined with Rolapitant.
Brexpiprazole	Brexpiprazole Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Brexpiprazole.
Ziprasidone Injection	Ziprasidone Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.
Cariprazine	Cariprazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cariprazine.
Eluxadoline	Eluxadoline The risk or severity of constipation can be increased when Tapentadol is combined with Eluxadoline.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Tapentadol.
Lesinurad	Lesinurad The metabolism of Lesinurad can be decreased when combined with Tapentadol.
Brivaracetam Injection	Brivaracetam Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Brivaracetam.
Cobicistat	Cobicistat The metabolism of Tapentadol can be decreased when combined with Cobicistat.
Pimavanserin	Pimavanserin Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pimavanserin.
Diphenhydramine Injection	Diphenhydramine Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.
Furosemide Injection	Furosemide Injection The therapeutic efficacy of Furosemide can be decreased when used in combination with Tapentadol.
Rucaparib	Rucaparib The metabolism of Tapentadol can be decreased when combined with Rucaparib.
Doxepin (Insomnia)	Doxepin (Insomnia) Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Plecanatide	Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Tapentadol.
Deutetrabenazine	Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Tapentadol.
Valbenazine	Valbenazine The metabolism of Valbenazine can be decreased when combined with Tapentadol.
Safinamide	Safinamide The risk or severity of adverse effects can be increased when Tapentadol is combined with Safinamide.
Naldemedine	Naldemedine The therapeutic efficacy of Tapentadol can be decreased when used in combination with Naldemedine.
Midostaurin	Midostaurin The metabolism of Tapentadol can be decreased when combined with Midostaurin.
Enasidenib	Enasidenib The metabolism of Tapentadol can be decreased when combined with Enasidenib.
Delafloxacin	Delafloxacin The metabolism of Tapentadol can be increased when combined with Delafloxacin.
Letermovir	Letermovir The metabolism of Letermovir can be decreased when combined with Tapentadol.
Tetrabenazine	Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Tapentadol.
Ertugliflozin	Ertugliflozin The therapeutic efficacy of Ertugliflozin can be decreased when used in combination with Tapentadol.
Buprenorphine Injection	Buprenorphine Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide	Apalutamide The metabolism of Tapentadol can be increased when combined with Apalutamide.
Avatrombopag	Avatrombopag The metabolism of Tapentadol can be increased when combined with Avatrombopag.
Lofexidine	Lofexidine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lofexidine.
Eliglustat	Eliglustat The metabolism of Eliglustat can be decreased when combined with Tapentadol.
Encorafenib	Encorafenib The metabolism of Encorafenib can be decreased when combined with Tapentadol.
Elagolix	Elagolix The metabolism of Elagolix can be decreased when combined with Tapentadol.
Tafenoquine	Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Tapentadol.
Cannabidiol	Cannabidiol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cannabidiol.
Dacomitinib	Dacomitinib The metabolism of Tapentadol can be decreased when combined with Dacomitinib.
Stiripentol	Stiripentol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.
Gilteritinib	Gilteritinib The therapeutic efficacy of Tapentadol can be decreased when used in combination with Gilteritinib.
Rifamycin	Rifamycin The metabolism of Tapentadol can be decreased when combined with Rifamycin.
Prucalopride	Prucalopride The therapeutic efficacy of Prucalopride can be decreased when used in combination with Tapentadol.
Magnesium Citrate	Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Tapentadol.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Tapentadol can be increased when combined with Emapalumab.
Siponimod	Siponimod The metabolism of Siponimod can be decreased when combined with Tapentadol.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Tapentadol.
Alpelisib	Alpelisib The serum concentration of Tapentadol can be decreased when it is combined with Alpelisib.
Brexanolone Injection	Brexanolone Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Brexanolone.
Solriamfetol	Solriamfetol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Solriamfetol.
Triclabendazole	Triclabendazole The metabolism of Tapentadol can be decreased when combined with Triclabendazole.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Tapentadol.
Pitolisant	Pitolisant The metabolism of Pitolisant can be decreased when combined with Tapentadol.
Fedratinib	Fedratinib The metabolism of Tapentadol can be decreased when combined with Fedratinib.
Phenytoin Injection	Phenytoin Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Phenytoin.
Fosphenytoin Injection	Fosphenytoin Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.
Voxelotor	Voxelotor The metabolism of Voxelotor can be decreased when combined with Tapentadol.
Avapritinib	Avapritinib The metabolism of Avapritinib can be decreased when combined with Tapentadol.
Lumateperone	Lumateperone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lumateperone.
Lasmiditan	Lasmiditan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lasmiditan.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Tapentadol.
Lemborexant	Lemborexant Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Fenfluramine	Fenfluramine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fenfluramine.
Pralsetinib	Pralsetinib The metabolism of Tapentadol can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Tapentadol can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Drospirenone can be decreased when used in combination with Tapentadol.
Viloxazine	Viloxazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Viloxazine.
Theophylline	Theophylline The metabolism of Theophylline can be decreased when combined with Tapentadol.
Indomethacin	Indomethacin The metabolism of Tapentadol can be decreased when combined with Indomethacin.
Mefenamic Acid	Mefenamic Acid The metabolism of Tapentadol can be decreased when combined with Mefenamic acid.
Naproxen	Naproxen The metabolism of Tapentadol can be decreased when combined with Naproxen.
Trazodone	Trazodone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Hydroxyurea	Hydroxyurea The metabolism of Tapentadol can be decreased when combined with Hydroxyurea.
Floxuridine	Floxuridine The metabolism of Tapentadol can be decreased when combined with Floxuridine.
Phenobarbital	Phenobarbital Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.
Metaxalone	Metaxalone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
Levorphanol	Levorphanol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
Primidone	Primidone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Primidone.
Methsuximide	Methsuximide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Methsuximide.
Diethylpropion	Diethylpropion Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Diethylpropion.
Chlorpromazine	Chlorpromazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.
Diazepam	Diazepam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Diazepam.
Oxazepam	Oxazepam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Oxazepam.
Flurazepam	Flurazepam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
Clorazepate	Clorazepate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Clorazepic acid.
Lorazepam	Lorazepam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
Amantadine	Amantadine The risk or severity of adverse effects can be increased when Amantadine is combined with Tapentadol.
Codeine	Codeine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Codeine.
Meprobamate	Meprobamate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Meprobamate.
Chlordiazepoxide	Chlordiazepoxide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
Bromocriptine	Bromocriptine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Bromocriptine.
Tranylcypromine	Tranylcypromine The risk or severity of adverse effects can be increased when Tapentadol is combined with Tranylcypromine.
Phenelzine	Phenelzine The risk or severity of adverse effects can be increased when Tapentadol is combined with Phenelzine.
Procarbazine	Procarbazine The risk or severity of adverse effects can be increased when Tapentadol is combined with Procarbazine.
Ergoloid Mesylates	Ergoloid Mesylates Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ergoloid mesylate.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.
Prochlorperazine	Prochlorperazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Prochlorperazine.
Thioridazine	Thioridazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Thioridazine.
Trifluoperazine	Trifluoperazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Trifluoperazine.
Dapsone	Dapsone The metabolism of Tapentadol can be decreased when combined with Dapsone.
Sulfadiazine	Sulfadiazine The metabolism of Tapentadol can be decreased when combined with Sulfadiazine.
Oxycodone	Oxycodone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Tapentadol.
Oxybutynin	Oxybutynin The risk or severity of adverse effects can be increased when Tapentadol is combined with Oxybutynin.
Benztropine	Benztropine The risk or severity of adverse effects can be increased when Tapentadol is combined with Benzatropine.
Maprotiline	Maprotiline Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Ibuprofen	Ibuprofen The metabolism of Tapentadol can be decreased when combined with Ibuprofen.
Trihexyphenidyl	Trihexyphenidyl The risk or severity of adverse effects can be increased when Tapentadol is combined with Trihexyphenidyl.
Orphenadrine	Orphenadrine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine	Perphenazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Perphenazine.
Fluphenazine	Fluphenazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fluphenazine.
Phentermine	Phentermine Phentermine may increase the analgesic activities of Tapentadol.
Amoxapine	Amoxapine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Doxorubicin	Doxorubicin The metabolism of Tapentadol can be decreased when combined with Doxorubicin.
Carbamazepine	Carbamazepine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Carbamazepine.
Molindone	Molindone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Molindone.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Tapentadol.
Cimetidine	Cimetidine The metabolism of Tapentadol can be decreased when combined with Cimetidine.
Warfarin	Warfarin The metabolism of Warfarin can be decreased when combined with Tapentadol.
Clonazepam	Clonazepam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
Loperamide	Loperamide The metabolism of Loperamide can be decreased when combined with Tapentadol.
Promethazine	Promethazine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
Loxapine	Loxapine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Loxapine.
Chloroquine	Chloroquine The metabolism of Tapentadol can be decreased when combined with Chloroquine.
Quinine	Quinine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Quinine.
Ethosuximide	Ethosuximide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ethosuximide.
Triamterene	Triamterene The therapeutic efficacy of Triamterene can be decreased when used in combination with Tapentadol.
Lactulose	Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Tapentadol.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Tapentadol can be decreased when combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Tapentadol.
Chlorthalidone	Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tapentadol.
Metolazone	Metolazone The therapeutic efficacy of Metolazone can be decreased when used in combination with Tapentadol.
Isosorbide	Isosorbide The therapeutic efficacy of Isosorbide can be decreased when used in combination with Tapentadol.
Secobarbital	Secobarbital Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Secobarbital.
Desipramine	Desipramine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Tapentadol.
Imipramine	Imipramine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
Probenecid	Probenecid The metabolism of Tapentadol can be decreased when combined with Probenecid.
Quinidine	Quinidine The risk or severity of adverse effects can be increased when Tapentadol is combined with Quinidine.
Procainamide	Procainamide The metabolism of Procainamide can be decreased when combined with Tapentadol.
Isoniazid	Isoniazid The metabolism of Tapentadol can be decreased when combined with Isoniazid.
Rifampin	Rifampin The metabolism of Tapentadol can be increased when combined with Rifampicin.
Disopyramide	Disopyramide The risk or severity of adverse effects can be increased when Tapentadol is combined with Disopyramide.
Valproic Acid	Valproic Acid Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Valproic acid.
Tamoxifen	Tamoxifen The metabolism of Tapentadol can be decreased when combined with Tamoxifen.
Butabarbital	Butabarbital Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
Methimazole	Methimazole The metabolism of Tapentadol can be decreased when combined with Methimazole.
Chlorpropamide	Chlorpropamide The metabolism of Tapentadol can be decreased when combined with Chlorpropamide.
Tolbutamide	Tolbutamide The metabolism of Tapentadol can be decreased when combined with Tolbutamide.
Tolazamide	Tolazamide The metabolism of Tapentadol can be decreased when combined with Tolazamide.
Dextromethorphan	Dextromethorphan Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dextromethorphan.
Cyclobenzaprine	Cyclobenzaprine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
Niacin	Niacin The metabolism of Tapentadol can be decreased when combined with Niacin.
Baclofen	Baclofen Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Baclofen.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.
Cyproheptadine	Cyproheptadine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine	Clemastine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Clemastine.
Chlorpheniramine	Chlorpheniramine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlorpheniramine.
Brompheniramine	Brompheniramine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.
Meclizine	Meclizine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
Methyclothiazide	Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Tapentadol.
Hydrochlorothiazide	Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Tapentadol.
Dantrolene	Dantrolene Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dantrolene.
Chlorzoxazone	Chlorzoxazone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.
Carisoprodol	Carisoprodol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Carisoprodol.
Methocarbamol	Methocarbamol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Tapentadol.
Pseudoephedrine	Pseudoephedrine Pseudoephedrine may increase the analgesic activities of Tapentadol.
Nortriptyline	Nortriptyline Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
Spironolactone	Spironolactone The therapeutic efficacy of Spironolactone can be decreased when used in combination with Tapentadol.
Nadolol	Nadolol The metabolism of Nadolol can be decreased when combined with Tapentadol.
Butorphanol Injection	Butorphanol Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Butorphanol.
Nalbuphine Injection	Nalbuphine Injection Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Nalbuphine.
Trimethobenzamide	Trimethobenzamide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Trimethobenzamide.
Flavoxate	Flavoxate The risk or severity of adverse effects can be increased when Tapentadol is combined with Flavoxate.
Fluorouracil Injection	Fluorouracil Injection The metabolism of Tapentadol can be decreased when combined with Fluorouracil.
Acetazolamide	Acetazolamide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Acetazolamide.
Ketoconazole	Ketoconazole The metabolism of Tapentadol can be decreased when combined with Ketoconazole.
Pyrantel	Pyrantel Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pyrantel.
Vinblastine	Vinblastine The metabolism of Tapentadol can be decreased when combined with Vinblastine.
Ethacrynic Acid	Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Tapentadol.
Metoprolol	Metoprolol The metabolism of Tapentadol can be decreased when combined with Metoprolol.
Hydroxyzine	Hydroxyzine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.
Thiothixene	Thiothixene Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Thiothixene.
Aspirin	Aspirin The metabolism of Tapentadol can be decreased when combined with Acetylsalicylic acid.
Alprazolam	Alprazolam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
Temazepam	Temazepam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
Triazolam	Triazolam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
Dicyclomine	Dicyclomine The risk or severity of adverse effects can be increased when Tapentadol is combined with Dicyclomine.
Hyoscyamine	Hyoscyamine The risk or severity of adverse effects can be increased when Tapentadol is combined with Hyoscyamine.
Propantheline	Propantheline The risk or severity of adverse effects can be increased when Tapentadol is combined with Propantheline.
Trimethoprim	Trimethoprim The metabolism of Tapentadol can be decreased when combined with Trimethoprim.
Diltiazem	Diltiazem The metabolism of Diltiazem can be decreased when combined with Tapentadol.
Nifedipine	Nifedipine The metabolism of Nifedipine can be decreased when combined with Tapentadol.
Timolol	Timolol The metabolism of Timolol can be decreased when combined with Tapentadol.
Verapamil	Verapamil The metabolism of Tapentadol can be decreased when combined with Verapamil.
Atenolol	Atenolol The metabolism of Atenolol can be decreased when combined with Tapentadol.
Pindolol	Pindolol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pindolol.
Cisplatin Injection	Cisplatin Injection The metabolism of Tapentadol can be decreased when combined with Cisplatin.
Diflunisal	Diflunisal The metabolism of Tapentadol can be decreased when combined with Diflunisal.
Piroxicam	Piroxicam The metabolism of Tapentadol can be decreased when combined with Piroxicam.
Bumetanide	Bumetanide The therapeutic efficacy of Bumetanide can be decreased when used in combination with Tapentadol.
Glyburide	Glyburide The metabolism of Tapentadol can be decreased when combined with Glyburide.
Glipizide	Glipizide The metabolism of Tapentadol can be decreased when combined with Glipizide.
Indapamide	Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Tapentadol.
Pentamidine Injection	Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Tapentadol.
Labetalol	Labetalol The metabolism of Tapentadol can be decreased when combined with Labetalol.
Gemfibrozil	Gemfibrozil The metabolism of Tapentadol can be decreased when combined with Gemfibrozil.
Pimozide	Pimozide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pimozide.
Flurbiprofen	Flurbiprofen The metabolism of Tapentadol can be decreased when combined with Flurbiprofen.
Amiodarone	Amiodarone The metabolism of Tapentadol can be decreased when combined with Amiodarone.
Buspirone	Buspirone The metabolism of Buspirone can be decreased when combined with Tapentadol.
Lovastatin	Lovastatin The metabolism of Tapentadol can be decreased when combined with Lovastatin.
Diclofenac	Diclofenac The metabolism of Tapentadol can be decreased when combined with Diclofenac.
Fluoxetine	Fluoxetine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fluoxetine.
Clozapine	Clozapine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Clozapine.
Estazolam	Estazolam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Estazolam.
Idarubicin	Idarubicin The metabolism of Idarubicin can be decreased when combined with Tapentadol.
Etodolac	Etodolac The metabolism of Tapentadol can be decreased when combined with Etodolac.
Felodipine	Felodipine The metabolism of Tapentadol can be decreased when combined with Felodipine.
Nabumetone	Nabumetone The metabolism of Tapentadol can be decreased when combined with Nabumetone.
Simvastatin	Simvastatin The metabolism of Tapentadol can be decreased when combined with Simvastatin.
Teniposide Injection	Teniposide Injection The metabolism of Tapentadol can be decreased when combined with Teniposide.
Atovaquone	Atovaquone The metabolism of Tapentadol can be decreased when combined with Atovaquone.
Sotalol	Sotalol The metabolism of Sotalol can be decreased when combined with Tapentadol.
Zolpidem	Zolpidem Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin	Doxazosin The metabolism of Doxazosin can be decreased when combined with Tapentadol.
Omeprazole	Omeprazole The metabolism of Tapentadol can be decreased when combined with Omeprazole.
Cisapride	Cisapride Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cisapride.
Gabapentin	Gabapentin Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.
Fluvastatin	Fluvastatin The metabolism of Tapentadol can be decreased when combined with Fluvastatin.
Venlafaxine	Venlafaxine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Venlafaxine.
Fluvoxamine	Fluvoxamine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fluvoxamine.
Nefazodone	Nefazodone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Nefazodone.
Lamotrigine	Lamotrigine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
Losartan	Losartan The metabolism of Tapentadol can be decreased when combined with Losartan.
Tramadol	Tramadol The risk or severity of serotonin syndrome can be increased when Tapentadol is combined with Tramadol.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Tapentadol can be decreased when combined with Vinorelbine.
Lansoprazole	Lansoprazole The metabolism of Tapentadol can be decreased when combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Tapentadol can be decreased when combined with Ifosfamide.
Nicardipine	Nicardipine The metabolism of Tapentadol can be decreased when combined with Nicardipine.
Bupropion	Bupropion Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Bupropion.
Ticlopidine	Ticlopidine The metabolism of Tapentadol can be decreased when combined with Ticlopidine.
Saquinavir	Saquinavir The metabolism of Tapentadol can be decreased when combined with Saquinavir.
Riluzole	Riluzole Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Riluzole.
Glimepiride	Glimepiride The metabolism of Tapentadol can be decreased when combined with Glimepiride.
Ritonavir	Ritonavir The metabolism of Tapentadol can be decreased when combined with Ritonavir.
Clomipramine	Clomipramine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Clomipramine.
Zafirlukast	Zafirlukast The metabolism of Tapentadol can be decreased when combined with Zafirlukast.
Mirtazapine	Mirtazapine Tapentadol may increase the serotonergic activities of Mirtazapine.
Topiramate	Topiramate Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Topiramate.
Zileuton	Zileuton The metabolism of Tapentadol can be decreased when combined with Zileuton.
Valsartan	Valsartan The metabolism of Tapentadol can be decreased when combined with Valsartan.
Pramipexole	Pramipexole Tapentadol may increase the sedative activities of Pramipexole.
Donepezil	Donepezil Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Donepezil.
Nelfinavir	Nelfinavir The metabolism of Tapentadol can be decreased when combined with Nelfinavir.
Carvedilol	Carvedilol The metabolism of Carvedilol can be decreased when combined with Tapentadol.
Nilutamide	Nilutamide The metabolism of Tapentadol can be decreased when combined with Nilutamide.
Selegiline	Selegiline The risk or severity of adverse effects can be increased when Tapentadol is combined with Selegiline.
Bicalutamide	Bicalutamide The metabolism of Tapentadol can be decreased when combined with Bicalutamide.
Sertraline	Sertraline Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Propafenone	Propafenone The metabolism of Tapentadol can be decreased when combined with Propafenone.
Irbesartan	Irbesartan The metabolism of Tapentadol can be decreased when combined with Irbesartan.
Tamsulosin	Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Tapentadol.
Ropinirole	Ropinirole Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ropinirole.
Quetiapine	Quetiapine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
Cetirizine	Cetirizine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cetirizine.
Paroxetine	Paroxetine Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Paroxetine.
Tolcapone	Tolcapone Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.
Citalopram	Citalopram Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Citalopram.
Capecitabine	Capecitabine The metabolism of Tapentadol can be decreased when combined with Capecitabine.
Efavirenz	Efavirenz Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Efavirenz.
Sildenafil	Sildenafil The metabolism of Sildenafil can be decreased when combined with Tapentadol.
Celecoxib	Celecoxib The metabolism of Tapentadol can be decreased when combined with Celecoxib.
Rosiglitazone	Rosiglitazone The metabolism of Tapentadol can be decreased when combined with Rosiglitazone.
Tolterodine	Tolterodine The risk or severity of adverse effects can be increased when Tapentadol is combined with Tolterodine.
Thalidomide	Thalidomide Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Nateglinide	Nateglinide The metabolism of Nateglinide can be decreased when combined with Tapentadol.
Galantamine	Galantamine The metabolism of Galantamine can be decreased when combined with Tapentadol.
Levetiracetam	Levetiracetam Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
Rabeprazole	Rabeprazole The metabolism of Tapentadol can be decreased when combined with Rabeprazole.
Terbinafine	Terbinafine The metabolism of Tapentadol can be decreased when combined with Terbinafine.