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Rabeprazole

Rabeprazole is a proton pump inhibitor (acid reducer) used to treat gastroesophageal reflux disease (GERD), duodenal ulcers, H. pylori infection with duodenal ulcer disease, and conditions that cause too much stomach acid, such as Zollinger-Ellison syndrome.

Brand names AcipHexAcipHex Sprinkles
Drug class Proton Pump Inhibitors
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 41 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

How we combine label and product data →
✓No current FDA shortage listed · checked Oct 4, 2026
Rabeprazole at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Rabeprazole (AcipHex) is a proton pump inhibitor that blocks the stomach's “acid pump” to treat GERD (acid reflux), duodenal ulcers, H. pylori (with two antibiotics) and rarer conditions that make too much acid; on the market since about 1999 and available as a generic, it works like omeprazole. Most people tolerate it well, and side effects are usually mild, such as headache, gas or constipation. Watch for diarrhea that will not settle (possible C. difficile), and know that long-term use is linked to low magnesium, low vitamin B-12 and fractures. If symptoms persist or return soon after stopping, tell your prescriber, because relief does not rule out stomach cancer.

Clinical pearls

  • Swallow the delayed-release tablet whole, because chewing, crushing or splitting it lets stomach acid destroy the medicine before it works.
  • For duodenal ulcers take it after a meal, and for H. pylori take it with food alongside amoxicillin and clarithromycin.
  • It can cause a false positive urine THC (marijuana) test, so mention it before any drug screen.
  • Never combine it with rilpivirine HIV medicines, and expect extra INR blood checks if you also take warfarin.
How we write & review this content — our editorial policy →
How you get itPrescription only
Comes asDelayed-release tablet
Earliest FDA record1999
Companies listing it with the FDA36
FDA label last updatedNov 30, 2023
FDA’s strongest warning (boxed)None on the label

Patient information guide — a plain-language walkthrough of Rabeprazole, written from its FDA label.

What Rabeprazole is used for

▾

Rabeprazole delayed-release tablets are used for these conditions:

  • Healing erosive or ulcerative GERD in adults (AcipHex and Rabeprazole Sodium)
  • Keeping erosive or ulcerative GERD healed in adults
  • Treating daytime and nighttime heartburn and other symptoms of GERD in adults
  • Healing duodenal ulcers in adults
  • Treating H. pylori infection with duodenal ulcer disease, together with amoxicillin and clarithromycin, to lower the risk of ulcer coming back
  • Long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome, in adults
  • Short-term treatment of symptomatic GERD in adolescents 12 and older

How Rabeprazole works

▾

Rabeprazole is a proton pump inhibitor. It blocks an enzyme (the H+/K+ ATPase, or “acid pump”) on the stomach’s acid-making cells. This is the final step in making stomach acid.

It is not an antihistamine-type (H2) acid reducer. Its effect on acid lasts longer than the drug stays in your blood.

Rabeprazole dosage

▾

Rabeprazole delayed-release tablets are swallowed whole, usually once daily. Treatment length depends on the condition, from a few weeks to long-term use.

  • Do not chew, crush or split the tablets.
  • For most uses, take with or without food.
  • AcipHex is taken after a meal for duodenal ulcers and with food for H. pylori treatment.
  • For H. pylori, all three medicines are taken twice daily for 7 days. Finish the full course.
  • AcipHex missed dose: take it as soon as you can, unless it is nearly time for the next one. Never double up.

Follow your prescriber’s directions.

Dosing details from the FDA-approved label

From the Rabeprazole prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Healing of Erosive or Ulcerative Gastroesophageal Reflux Disease (GERD) in Adults
    • 20 mg once daily for 4 to 8 weeks
    • For those not healed after 8 weeks, an additional 8-week course may be considered
    • Can be taken with or without food
  • Maintenance of Healing of Erosive or Ulcerative GERD in Adults
    • 20 mg once daily
    • Controlled studies do not extend beyond 12 months
  • Treatment of Symptomatic GERD in Adults
    • 20 mg once daily for 4 weeks
    • If symptoms do not resolve completely after 4 weeks, an additional course of treatment may be considered
    • Can be taken with or without food
  • Healing of Duodenal Ulcers in Adults
    • 20 mg once daily after the morning meal for a period up to four weeks
    • A few patients may require additional therapy to achieve healing
    • Take after the morning meal
  • Helicobacter pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence in Adults
    • Rabeprazole 20 mg, Amoxicillin 1000 mg and Clarithromycin 500 mg, all three twice daily for 7 days
    • Take with morning and evening meals; comply with the full 7-day regimen
  • Pathological Hypersecretory Conditions, Including Zollinger-Ellison Syndrome in Adults
    • Starting dose 60 mg once a day, then adjust to individual patient needs and continue as long as clinically indicated
    • Some patients may require divided doses
    • Maximum: Doses up to 100 mg QD and 60 mg BID have been administered
    • Some patients with Zollinger-Ellison syndrome have been treated continuously for up to one year
  • Symptomatic GERD in Adolescents 12 Years of Age and Older
    • 20 mg once daily for up to 8 weeks
    • Can be taken with or without food
  • Elderly, renal and hepatic impaired patients
    • No dosage adjustment is necessary in elderly patients, in patients with renal disease or in patients with mild to moderate hepatic impairment
    • Caution in patients with severe hepatic impairment due to lack of clinical data
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION Indication Recommended Dosage ( 2 ) Healing of Erosive or Ulcerative Gastroesophageal Reflux Disease (GERD) 20 mg once daily for 4 to 8 weeks Maintenance of Healing of Erosive or Ulcerative GERD* studied for 12 months 20 mg once daily* Symptomatic GERD in Adults 20 mg once daily for 4 weeks Healing of Duodenal Ulcers 20 mg once daily after morning meal for up to 4 weeks Helicobacter pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence Three Drug Regimen: Rabeprazole sodium delayed-release tablets 20 mg Amoxicillin 1,000 mg Clarithromycin 500 mg All three medications should be taken twice daily with morning and evening meals for 7 days. Pathological Hypersecretory Conditions, Including Zollinger-Ellison Syndrome Starting dose 60 mg once daily then adjust to patient needs Symptomatic GERD in Adolescents 12 Years of Age and Older 20 mg once daily for up to 8 weeks Administration Instructions ( 2 ) : • Swallow rabeprazole sodium delayed-release tablets whole. Do not chew, crush or split the tablets. • For the treatment of duodenal ulcers take rabeprazole sodium delayed-release tablets after a meal. • For Helicobacter pylori eradication take rabeprazole sodium delayed-release tablets with food. • For all other indications rabeprazole sodium delayed-release tablets can be taken with or without food. Table 1 shows the recommended dosage of rabeprazole sodium delayed-release tablets in adults and adolescent patients 12 years of age and older. The use of rabeprazole sodium delayed-release tablets is not recommended for use in pediatric patients 1 year to less than 12 years of age because the lowest available tablet strength (20 mg) exceeds the recommended dose for these patients. Use another rabeprazole formulation for pediatric patients 1 year to less than 12 years of age. Table 1: Recommended Dosage and Duration of Rabeprazole Sodium Delayed-Release Tablets in Adults and Adolescents 12 Years of Age and Older * For those patients who have not healed after 8 weeks of treatment, an additional 8-week course of rabeprazole sodium delayed-release tablets may be considered. ** If symptoms do not resolve completely after 4 weeks, an additional course of treatment may be considered. *** Most patients heal within 4 weeks; some patients may require additional therapy to achieve healing.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Rabeprazole side effects

▾

Common side effects

  • Pain
  • Sore throat (pharyngitis)
  • Gas (flatulence)
  • Infection
  • Constipation
  • Headache (more common in adolescents)
  • Diarrhea, nausea, vomiting or belly pain in adolescents

When to get medical help

  • Call your doctor if you have diarrhea that does not get better, which could be a C. difficile infection.
  • Get help right away for signs of a serious allergic reaction, such as swelling, trouble breathing or hives.
  • Stop the medicine and call your doctor if you get a severe skin rash, blistering or peeling.
  • Call your doctor about a new or worsening rash, especially on sun-exposed skin, or joint pain, which could be lupus.
  • Tell your doctor about symptoms of kidney problems, such as feeling unwell, nausea or loss of appetite.
  • Report muscle spasms, irregular heartbeat or seizures, which can be signs of low magnesium.
  • Tell your doctor if your symptoms come back soon after treatment ends or do not improve.

Most people tolerate rabeprazole well. Common side effects include:

  • Pain
  • Sore throat
  • Gas
  • Infection
  • Constipation
  • In adolescents: headache, diarrhea, nausea, vomiting and belly pain

Call your doctor for severe skin reactions, signs of an allergic reaction, diarrhea that does not go away, or symptoms of kidney problems or low magnesium.

Rabeprazole warnings and precautions

▾
  • Allergic and skin reactions: serious reactions, including Stevens-Johnson syndrome, have been reported. Stop the medicine at the first signs.
  • Stomach cancer: symptom relief does not rule it out in adults.
  • Kidney inflammation: acute tubulointerstitial nephritis can happen at any time.
  • C. difficile diarrhea: may be linked to PPIs, especially in hospitalized patients.
  • Long-term use: linked to fractures of the hip, wrist or spine, low vitamin B-12, low magnesium and fundic gland polyps.
  • Lupus: new or worsening lupus has been reported.

Rabeprazole interactions

▾

Rabeprazole can affect other medicines, and some can affect it:

  • Rilpivirine: must not be combined.
  • Nelfinavir: avoid combining.
  • Atazanavir and saquinavir: levels can change, so follow their prescribing information.
  • Warfarin: may raise INR and bleeding risk.
  • Methotrexate: levels may rise and cause toxicity.
  • Digoxin and tacrolimus: levels may rise.
  • Iron salts, ketoconazole, itraconazole, erlotinib, dasatinib, nilotinib and mycophenolate mofetil: absorption may fall because of lower stomach acid.
  • Lab tests: it can affect tests for neuroendocrine tumors and secretin, and cause false positive urine THC results.

Interactions listed in the FDA-approved label

From the Rabeprazole prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Antiretrovirals (rilpivirine, atazanavir, nelfinavir, saquinavir): The effect of PPIs on antiretrovirals is variable; exposure of some (e.g., rilpivirine, atazanavir, nelfinavir) is decreased, which may reduce antiviral effect and promote drug resistance, while exposure of others (e.g., saquinavir) is increased and may increase toxicity. Rilpivirine-containing products: concomitant use is contraindicated. Nelfinavir: avoid concomitant use. Saquinavir: monitor for potential toxicities. Atazanavir and others: see prescribing information.
  • Warfarin: Increased INR and prothrombin time, which may lead to abnormal bleeding and even death. Monitor INR and prothrombin time; dose adjustment of warfarin may be needed to maintain target INR range.
  • Methotrexate: May elevate and prolong serum levels of methotrexate and/or its metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities. A temporary withdrawal of rabeprazole may be considered in some patients receiving high dose methotrexate.
  • Digoxin: Potential for increased exposure of digoxin. Monitor digoxin concentrations; dose adjustment of digoxin may be needed.
  • Drugs dependent on gastric pH for absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole, itraconazole): Rabeprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity; with mycophenolate mofetil, exposure to mycophenolic acid has been reported to be reduced. Use with caution in transplant patients receiving MMF; see prescribing information for other drugs dependent on gastric pH.
  • Clarithromycin and amoxicillin (combination therapy): Concomitant administration of clarithromycin with other drugs can lead to serious adverse reactions, including potentially fatal arrhythmias, and are contraindicated; amoxicillin also has drug interactions. See Contraindications and Warnings and Precautions in clarithromycin prescribing information and Drug Interactions in amoxicillin prescribing information.
  • Tacrolimus: Potentially increased exposure of tacrolimus, especially in transplant patients who are intermediate or poor metabolizers of CYP2C19. Monitor tacrolimus whole blood trough concentrations; dose adjustment may be needed.
  • Investigations of neuroendocrine tumors (serum chromogranin A): CgA levels increase secondary to PPI-induced decreases in gastric acidity, which may cause false positive results in diagnostic investigations for neuroendocrine tumors. Temporarily stop rabeprazole at least 14 days before assessing CgA levels and consider repeating the test if initial levels are high; use the same laboratory for serial tests.
  • Secretin stimulation test: Hyper-response in gastrin secretion in response to secretin stimulation test, falsely suggesting gastrinoma. Temporarily stop rabeprazole at least 14 days before assessing to allow gastrin levels to return to baseline.
  • Urine screening tests for THC: There have been reports of false positive urine screening tests for tetrahydrocannabinol in patients receiving PPIs. An alternative confirmatory method should be considered to verify positive results.
Read the label’s full interactions text

7 DRUG INTERACTIONS See full prescribing information for a list of clinically important drug interactions ( 7 ). Table 2 includes drugs with clinically important drug interactions and interaction with diagnostics when administered concomitantly with rabeprazole sodium delayed-release tablets and instructions for preventing or managing them. Consult the labeling of concomitantly used drugs to obtain further information about interactions with PPIs. Table 2: Clinically Relevant Interactions Affecting Drugs Co-Administered with Rabeprazole Sodium Delayed-Release Tablets and Interactions with Diagnostics Antiretrovirals Clinical Impact: The effect of PPI on antiretroviral drugs is variable. The clinical importance and the mechanisms behind these interactions are not always known. • Decreased exposure of some antiretroviral drugs (e.g., rilpivirine, atazanavir, and nelfinavir) when used concomitantly with rabeprazole may reduce antiviral effect and promote the development of drug resistance. • Increased exposure of other antiretroviral drugs (e.g., saquinavir) when used concomitantly with rabeprazole may increase toxicity . • There are other antiretroviral drugs which do not result in clinically relevant interactions with rabeprazole. Intervention: Rilpivirine-containing products : Concomitant use with rabeprazole sodium delayed-release tablets is contraindicated [see Contraindications ( 4 )] . See prescribing information. Atazanavir : See prescribing information for atazanavir for dosing information. Nelfinavir : Avoid concomitant use with rabeprazole sodium delayed-release tablets. See prescribing information for nelfinavir. Saquinavir: See the prescribing information for saquinavir and monitor for potential saquinavir toxicities. Other antiretrovirals : See prescribing information. Warfarin Clinical Impact: Increased INR and prothrombin time in patients receiving PPIs, including rabeprazole, and warfarin concomitantly.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿189 supplements and herbs with documented Rabeprazole interactions, ranked by severity Check Rabeprazole against a supplement or herb →

Before taking Rabeprazole

▾
  • Do not use it if you are allergic to rabeprazole or related drugs, or take rilpivirine.
  • Avoid in severe liver impairment. If treatment is needed, you will be monitored.
  • No dose change is needed for mild to moderate liver impairment, kidney disease, or older age.
  • There are no human pregnancy data. Animal studies did not show harm to the fetus.
  • It is not known if rabeprazole passes into breast milk. Talk with your doctor about the benefits of breastfeeding and your need for the medicine.
  • Not recommended for children under 12 as the 20 mg tablet is too strong.

Rabeprazole overdose

▾

In reported accidental overdoses, up to 80 mg, no symptoms were seen. There is no specific antidote. Treatment is symptom-based and supportive. If you take too much, call Poison Control at 1-800-222-1222.

What Rabeprazole does in the body

▾

Rabeprazole starts reducing stomach acid within one hour. After the first dose, it reaches about 88% of its maximum effect on 24-hour acidity. It also lowers acid in the esophagus in people with GERD. Its effect lasts much longer than the drug stays in the blood.

How your body processes Rabeprazole

▾

Blood levels peak about 2 to 5 hours after a dose. Food may delay absorption but does not change how much is absorbed. The drug is broken down mainly in the liver, partly by CYP2C19 and CYP3A enzymes. Some people are slow metabolizers of CYP2C19. About 90% leaves in the urine as metabolites. It does not build up with daily dosing.

How to store Rabeprazole

▾

Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F). Protect from moisture.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

189

Supplements & herbs that interact with Rabeprazole

189 supplements and herbal products have documented interactions with Rabeprazole in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 3
  • Moderate · 135
  • Minor · 51
ACTIVATED CHARCOAL Major GRAPEFRUIT Major ST. JOHN'S WORT Major ACACIA RIGIDULA Moderate ADRAFINIL Moderate AFRICAN WILD POTATO Moderate ALFALFA Moderate AMERICAN ELDER Moderate +181 more
Every supplement checked against Rabeprazole — ranked by severity The full interaction hub: 3 major · 119 moderate · 50 minor · every one linked to its full report. Check Rabeprazole against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

9

Nutrient depletion considerations

Rabeprazole has been associated with lower levels of 9 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

Evidence & significance mix
  • Higher significance · 5
  • Moderate · 1
  • Unrated · 3
CALCIUM Insignificant Depletion FOLIC ACID Insignificant Depletion IRON Insignificant Depletion MAGNESIUM Major Depletion ZINC Insignificant Depletion VITAMIN B12 Moderate Depletion BETA-CAROTENE Insufficient Evidence CHROMIUM Insufficient Evidence +1 more
See the full Rabeprazole nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Rabeprazole: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Rabeprazole — the kind of thing our pharmacy team would talk through with you at the counter.

What is rabeprazole for?

▾
It lowers stomach acid. Doctors use it for GERD, duodenal ulcers, H. pylori infection with duodenal ulcer disease, and conditions with too much stomach acid like Zollinger-Ellison syndrome. Adolescents 12 and older can use it for symptomatic GERD.

How should I take it?

▾
Swallow the tablet whole. Don’t chew, crush or split it. For most uses, food doesn’t matter. For duodenal ulcers, take it after a meal. For H. pylori, take it with food, twice a day with your antibiotics, and finish all 7 days.

What if I miss a dose?

▾
The AcipHex label says to take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Never take two doses together.

What side effects should I expect?

▾
Most are mild, like pain, sore throat, gas or constipation. Teens may get headache, nausea or diarrhea. Call me or your doctor if you have severe or lasting diarrhea, a bad rash or blistering skin, swelling, or muscle spasms.

Can I take it with my other medicines?

▾
Some medicines don’t mix well. Tell me if you take HIV medicines (especially rilpivirine, which can’t be combined), warfarin, methotrexate, digoxin, tacrolimus, or antifungals like ketoconazole. We may need to monitor or adjust some of them.

Is it safe to take for a long time?

▾
Longer use is linked to a higher chance of bone fractures, low vitamin B-12, low magnesium and stomach polyps. That’s why we use the lowest dose for the shortest time that works. Keep your doctor in the loop if you need it long-term.

Is Rabeprazole available over the counter?

▾
No. Rabeprazole is a prescription medicine: every Rabeprazole product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Rabeprazole first available?

▾
The earliest FDA record we hold for Rabeprazole is from 1999: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Rabeprazole was first used.

Who makes Rabeprazole?

▾
36 companies list Rabeprazole products in the FDA's NDC Directory, including Bryant Ranch Prepack, Remedyrepack Inc., Proficient Rx LP. That count includes repackagers and distributors as well as manufacturers, so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Rabeprazole on HelloPharmacist

📊Rabeprazole supplement interactions172 checked — ranked by severity 🌿Drug & Supplement CheckerRabeprazole vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Rabeprazole NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Rabeprazole Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Rabeprazole forms and strengths (how it comes)

Rabeprazole is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Delayed-release tablet

By mouth
Brands AcipHex
How this form is used
What it may be used for
  • AcipHex and Rabeprazole Sodium delayed-release tablets treat GERD, duodenal ulcers, and Zollinger-Ellison syndrome in adults.
  • AcipHex and Rabeprazole Sodium delayed-release tablets are used with amoxicillin and clarithromycin to treat H. pylori infection in adults with duodenal ulcer disease.
  • AcipHex and Rabeprazole Sodium delayed-release tablets treat symptomatic GERD in adolescents 12 and older for up to 8 weeks.
Important instructions
  • AcipHex and Rabeprazole Sodium tablets should be swallowed whole, not chewed, crushed or split.
  • AcipHex is taken after a meal for duodenal ulcers and with food for H. pylori treatment. For other uses it can be taken with or without food.
  • AcipHex: if you miss a dose, take it as soon as possible. If it is almost time for the next dose, skip it. Do not take two doses at once.
  • AcipHex is not recommended for children 1 to under 12 years because the lowest tablet strength is too high.
Available strengths 1 strength
20 mg
107 FDA-listed product records ⓘ

Rabeprazole on the U.S. market: products, makers and brands

How Rabeprazole appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

36 companies list 119 Rabeprazole product records with the FDA, mostly as delayed-release tablet; the earliest marketing or approval year on record is 1999. Brand names on the directory include AcipHex, AcipHex Sprinkles; the rest are generics.

1
Dose forms ⓘ
36
Labelers (makers, repackagers, distributors)
3
Brand names
119
FDA-listed product records ⓘ
1999
Earliest FDA record ⓘ

Also listed with the FDA, not a patient dose form: Powder (12) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack11%
Remedyrepack Inc.8%
Proficient Rx LP7%
Direct Rx7%
A-S Medication Solutions6%
Advanced Rx Pharmacy of Tennessee, LLC5%
Other makers56%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Rabeprazole is used (Medicaid data)

A general measure of how commonly Rabeprazole is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Rabeprazole is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

36,412
Medicaid prescriptions filled (Q1–Q4 2025)
$748,322 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Rabeprazole prescribed? Of the 1,601 medications we measure, Rabeprazole ranks #697 by Medicaid prescriptions — more than 56% of them.

Where Rabeprazole ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #697 of 1,601
#692 Diazepam Rectal 36,750 Rx #693 Armodafinil 36,520 Rx #694 Dabigatran 36,481 Rx #695 Dabigatran Etexilate 36,481 Rx #696 Sumatriptan Injection 36,417 Rx #697 Rabeprazole 36,412 Rx #698 Cimetidine 36,381 Rx #699 Dexamethasone Ophthalm... 36,282 Rx #700 Eletriptan 36,231 Rx #701 Repaglinide 35,787 Rx #702 Exemestane 35,645 Rx

Utilization by Rabeprazole product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

rabeprazole sodium 20 MG Delayed Release Oral Tablet

36,412 Medicaid prescriptions (Q1–Q4 2025) 100% of Rabeprazole prescriptions shown $748,322 gross reimbursement (before rebates) ≈ $21 per prescription (gross)

Summed across the 10 of 172 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 854868

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Rabeprazole, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 10 of 172 listed Rabeprazole NDCs with Medicaid activity.

Compare Rabeprazole products

A representative set of FDA-listed product records for Rabeprazole — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 119 of 119 products — FDA National Drug Code Directory. See every product, package size and price: browse all 119 Rabeprazole NDCs →

Rabeprazole side effects reported to the FDA (FAERS)

After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Rabeprazole — a signal of what to watch for, not proof the drug caused it.

The effects most often named in FDA reports that mention Rabeprazole are chronic kidney disease, renal failure, acute kidney injury; about 0% of the reports were classed as serious. These are voluntary reports, so they show what people report, not how often it happens.

38,148
Reports mentioning it
0%
Reported as serious
12
Distinct effects shown
Most reported effects
Chronic Kidney Disease
4,975
Renal Failure
3,535
Acute Kidney Injury
2,843
Nausea
2,520
Pain
2,037
Headache
2,004
Diarrhoea
1,939
Fatigue
1,910
Dyspnoea
1,902
Arthralgia
1,756
Age groups
Elderly · 2,321Adult · 2,315Adolescent · 11Neonate · 9Infant · 3Child · 3

Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Rabeprazole in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.

Rabeprazole FDA approval history

How Rabeprazole went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.

Rabeprazole was first approved by the FDA in 1999 (Brand: ACIPHEX · Waylis Therap); the first generic version was approved in 2013. It remains available in U.S. pharmacies today.

1999
Brand approved
Brand: ACIPHEX · Waylis Therap
2013
First generic approved
Lower-cost ANDA competition begins
2026
Available today
Active in U.S. pharmacies

Source: Drugs@FDA.

Rabeprazole recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Rabeprazole recalls since July 2021.

✅No Rabeprazole recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Rabeprazole RxCUI 114979 2 dose forms · 4 strengths
  1. Dose form (SCDF) Delayed Release Oral Tablet RxCUI 375256 In current FDA listings
    Clinical drug / strength (SCD) sodium 10 MG RxCUI 854872 sodium 20 MG RxCUI 854868
  2. Dose form (SCDF) Oral Granules RxCUI 1944639 No current FDA listing
    Clinical drug / strength (SCD) sodium 10 MG RxCUI 1483318 sodium 5 MG RxCUI 1437489

Look up RxCUI 114979 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

Rabeprazole brand names

Rabeprazole is sold under 2 brand names in the FDA directory — AcipHex, AcipHex Sprinkles. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

AcipHex AcipHex Sprinkles

Who makes Rabeprazole: manufacturers and labelers

36 companies list Rabeprazole products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, Remedyrepack Inc., Proficient Rx LP. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Bryant Ranch Prepack 13 Remedyrepack Inc. 10 Proficient Rx LP 8 Direct Rx 8 A-S Medication Solutions 7 Advanced Rx Pharmacy of Tennessee, LLC 6 Preferred Pharmaceuticals, Inc. 6 St. Mary's Medical Park Pharmacy 6 Aurobindo Pharma Limited 5 Preferred Pharmaceuticals Inc. 4 Torrent Pharmaceuticals Limited 4 Amneal Pharmaceuticals LLC 3 Ascend Laboratories, LLC 3 Asclemed USA, Inc. 3 Advanced Rx of Tennessee, LLC 3 Golden State Medical Supply, Inc. 3 Quimica Sintetica S.A. 2 Metrochem API Private Limited 2 Medsource Pharmaceuticals 2 Waylis Therapeutics LLC 2 Lannett Company, Inc. 2 Chartwell RX, LLC 2 Advagen Pharma Limited 2 UQUIFA Mexico, S.A. DE C.V. 1

…and 12 more on the FDA NDC directory.

Rabeprazole drug class (RxNorm)

Rabeprazole belongs to the Proton Pump Inhibitor class.

Pharmacologic class Proton Pump Inhibitor
Drug family (ATC) Proton pump inhibitors
How it works Proton Pump Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Rabeprazole page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Nov 30, 2023
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Rabeprazole.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Rabeprazole after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
41
Finished products in the current FDA directory
119
Companies listing them (makers, repackagers, distributors)
36
Linked representative label ⓘ
Amneal Pharmaceuticals LLC
Linked label effective
Nov 30, 2023
Composite sections available
24
Linked SPL Set ID
951caefe-6e18-48ff-9567-beb545b09c25
Linked SPL Document ID
f02b0373-dbac-4842-bf97-3352b8c74089
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Amneal Pharmaceuticals LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →