Lesinurad

Generic name: Pronounced as (le sin' ure ad)
Brand names
  • Zurampic®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 04/15/2016

Lesinurad may cause serious kidney problems. Tell your doctor if you are being treated with dialysis (treatment to clean the blood when the kidneys are not working well), have received a kidney transplant, or have or have ever had kidney disease. The risk that you will develop serious kidney problems is greater if you are taking lesinurad alone. Lesinurad must be taken in combination with a xanthine oxidase inhibitor such as allopurinol (Lopurin, Zyloprim) or febuxostat (Uloric). If you experience any of the following symptoms, call your doctor immediately: nausea, vomiting, or upper right stomach pain.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests before and during treatment to check your body's response to lesinurad.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with lesinurad and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

Lesinurad is used in combination with a xanthine oxidase inhibitor to treat hyperuricemia (high levels of uric acid) in people with gout (sudden attacks of redness, swelling, pain, and heat in one or more joints) whose disease is not controlled with their current medication. Lesinurad is in a class of medications called selective uric acid reabsorption inhibitors. It works by helping the kidneys to remove uric acid from the body.

Lesinurad comes as a tablet to take by mouth. It is usually taken once daily in the morning with food and water. Take lesinurad at around the same time every day and at the same time that you take a xanthine oxidase inhibitor such as allopurinol (Lopurin, Zyloprim) or febuxostat (Uloric). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lesinurad exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Lesinurad controls hyperuricemia in people with gout but does not cure it. Your gout may flare up (intense painful, swelling joint) when you first start taking lesinurad, but do not stop taking it. Your doctor will give you other medications to help prevent gout flares. Continue to take lesinurad even if you feel well or have a gout attack. Do not stop taking lesinurad without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking lesinurad,

  • tell your doctor and pharmacist if you are allergic to lesinurad, any other medications, or any of the ingredients in lesinurad tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Nexterone, Pacerone), amlodipine (Norvasc), aspirin, carbamazepine (Epitol, Equetro, Teril, others), fluconazole (Diflucan), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), sildenafil (Revatio, Viagra), or valproic acid (Depakene). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with lesinurad, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section, tumor lysis syndrome (a condition that causes cancer cells to break down quickly and release byproducts into the blood), or Lesch-Nyhan syndrome (an inherited disease that causes high levels of uric acid in the blood). Your doctor will probably tell you not to take lesinurad.

  • tell your doctor if you have or have ever had a stroke, a heart attack, high blood pressure, heart disease, high cholesterol, or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Hormonal contraceptives (birth control pills, patches, rings, shots, implants, and intrauterine devices) may not work well when used with lesinurad and should not be used as your only method of birth control. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking lesinurad, call your doctor.

Drink at least 68 ounces (2 liters) of water or other fluids every 24 hours while taking lesinurad unless directed to do otherwise by your doctor.

If you miss taking lesinurad in the morning, do not lake it later in the day. Continue your regular dosing schedule the next morning with food and water. Do not take a double dose to make up for a missed one.

  • Lesinurad may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • flu-like symptoms such as headache, fever, sweating, muscle aches, and tiredness

    • heartburn

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING sections, call your doctor immediately or get emergency medical treatment:

    • chest pain, pressure, or discomfort

    • shortness of breath or trouble breathing

    • weakness in one part or side of their body

    • slurred speech

  • Lesinurad may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Montelukast Montelukast The metabolism of Lesinurad can be decreased when combined with Montelukast.
Leflunomide Leflunomide The metabolism of Lesinurad can be decreased when combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Lesinurad can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Lesinurad can be decreased when combined with Nevirapine.
Aminophylline Aminophylline The metabolism of Aminophylline can be increased when combined with Lesinurad.
Candesartan Candesartan The metabolism of Lesinurad can be decreased when combined with Candesartan.
Cilostazol Cilostazol Cilostazol may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Clopidogrel Clopidogrel The metabolism of Lesinurad can be decreased when combined with Clopidogrel.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Fenofibrate Fenofibrate The metabolism of Lesinurad can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine Guanfacine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Magnesium Hydroxide Magnesium Hydroxide Magnesium hydroxide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Mycophenolate Mycophenolate Mycophenolic acid may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Potassium Potassium Potassium cation may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Prednisone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ranitidine Ranitidine Ranitidine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Reserpine Reserpine Reserpine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Rizatriptan Rizatriptan Rizatriptan may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Sumatriptan Sumatriptan Sumatriptan may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Tacrolimus Tacrolimus The metabolism of Lesinurad can be increased when combined with Tacrolimus.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection The metabolism of Lesinurad can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection Levofloxacin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Meperidine Injection Meperidine Injection The metabolism of Lesinurad can be increased when combined with Meperidine.
Metoclopramide Injection Metoclopramide Injection Metoclopramide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Metronidazole Injection Metronidazole Injection The metabolism of Lesinurad can be decreased when combined with Metronidazole.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Lesinurad may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Lesinurad can be decreased when combined with Zidovudine.
Altretamine Altretamine Amphetamine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Lesinurad can be increased when combined with Cyclosporine.
Ondansetron Ondansetron The metabolism of Lesinurad can be decreased when combined with Ondansetron.
Torsemide Torsemide The metabolism of Lesinurad can be decreased when combined with Torasemide.
Olanzapine Olanzapine The metabolism of Lesinurad can be decreased when combined with Olanzapine.
Alosetron Alosetron The metabolism of Lesinurad can be decreased when combined with Alosetron.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Lesinurad.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Temozolomide Temozolomide Temozolomide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Zaleplon Zaleplon Zaleplon may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Anakinra Anakinra The metabolism of Lesinurad can be increased when combined with Anakinra.
Trimipramine Trimipramine The metabolism of Lesinurad can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Lesinurad can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Lesinurad can be decreased when combined with Modafinil.
Perindopril Perindopril Perindopril may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Sirolimus Sirolimus The metabolism of Sirolimus can be increased when combined with Lesinurad.
Epinephrine Injection Epinephrine Injection The metabolism of Lesinurad can be decreased when combined with Epinephrine.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Zonisamide Zonisamide Zonisamide may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Adalimumab Injection Adalimumab Injection The metabolism of Lesinurad can be increased when combined with Adalimumab.
Atomoxetine Atomoxetine Atomoxetine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Almotriptan Almotriptan Almotriptan may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Eletriptan Eletriptan The metabolism of Lesinurad can be decreased when combined with Eletriptan.
Rosuvastatin Rosuvastatin The metabolism of Lesinurad can be increased when combined with Rosuvastatin.
Aprepitant Aprepitant The metabolism of Lesinurad can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Emtricitabine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Memantine Memantine Memantine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Tadalafil Tadalafil Tadalafil may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Progesterone Progesterone The metabolism of Lesinurad can be decreased when combined with Progesterone.
Infliximab Injection Infliximab Injection The metabolism of Lesinurad can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Lesinurad can be decreased when combined with Oxandrolone.
Duloxetine Duloxetine The metabolism of Lesinurad can be increased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Norethisterone can be increased when combined with Lesinurad.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Bosentan Bosentan The metabolism of Lesinurad can be increased when combined with Bosentan.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Erlotinib can be increased when combined with Lesinurad.
Eszopiclone Eszopiclone Eszopiclone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ganciclovir Ganciclovir Ganciclovir may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Valganciclovir Valganciclovir Valganciclovir may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Lesinurad can be decreased when combined with Voriconazole.
Adefovir Adefovir Adefovir may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Lesinurad can be increased when combined with Peginterferon alfa-2b.
Ramelteon Ramelteon Ramelteon may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Fentanyl Fentanyl Fentanyl may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Pregabalin Pregabalin Pregabalin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Felbamate Felbamate The metabolism of Lesinurad can be decreased when combined with Felbamate.
Ranolazine Ranolazine Ranolazine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Abatacept Injection Abatacept Injection The metabolism of Lesinurad can be increased when combined with Abatacept.
Rasagiline Rasagiline Rasagiline may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Imatinib Imatinib The metabolism of Lesinurad can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Sitagliptin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Varenicline Varenicline Varenicline may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Lesinurad can be decreased when combined with Gefitinib.
Albuterol Albuterol Salbutamol may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Paliperidone Paliperidone Paliperidone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Bortezomib Bortezomib The metabolism of Lesinurad can be increased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Lubiprostone Lubiprostone Lubiprostone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Pemetrexed Injection Pemetrexed Injection Lesinurad may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Nabilone Nabilone The metabolism of Lesinurad can be decreased when combined with Nabilone.
Sorafenib Sorafenib The metabolism of Lesinurad can be increased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be increased when combined with Lesinurad.
Dronabinol Dronabinol The metabolism of Lesinurad can be decreased when combined with Dronabinol.
Levocetirizine Levocetirizine Levocetirizine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Pegaptanib may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Dasatinib can be increased when combined with Lesinurad.
Armodafinil Armodafinil The metabolism of Lesinurad can be decreased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be increased when combined with Lesinurad.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Lesinurad can be increased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Lesinurad can be decreased when combined with Bexarotene.
Budesonide Budesonide Budesonide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Doripenem Injection Doripenem Injection Doripenem may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Etravirine Etravirine The metabolism of Lesinurad can be decreased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection Arsenic trioxide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine Desvenlafaxine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Tretinoin Tretinoin The metabolism of Lesinurad can be decreased when combined with Tretinoin.
Flecainide Flecainide The metabolism of Lesinurad can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Lesinurad can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Lesinurad.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Lesinurad.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Methylnaltrexone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Rufinamide Rufinamide The metabolism of Rufinamide can be increased when combined with Lesinurad.
Midazolam Midazolam Midazolam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Milnacipran Milnacipran Milnacipran may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Plerixafor Injection Plerixafor Injection Plerixafor may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Fesoterodine Fesoterodine Fesoterodine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Prasugrel Prasugrel Prasugrel may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Lacosamide Lacosamide The metabolism of Lesinurad can be increased when combined with Lacosamide.
Everolimus Everolimus The metabolism of Everolimus can be increased when combined with Lesinurad.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Lesinurad can be increased when combined with Tolvaptan.
Dronedarone Dronedarone The metabolism of Dronedarone can be increased when combined with Lesinurad.
Pralatrexate Injection Pralatrexate Injection Pralatrexate may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Palonosetron may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Saxagliptin Saxagliptin Saxagliptin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Telavancin Injection Telavancin Injection Telavancin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Lesinurad.
Tapentadol Tapentadol The metabolism of Lesinurad can be decreased when combined with Tapentadol.
Topotecan Topotecan Topotecan may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Golimumab Injection Golimumab Injection The metabolism of Lesinurad can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be increased when combined with Lesinurad.
Pitavastatin Pitavastatin The metabolism of Lesinurad can be decreased when combined with Pitavastatin.
Albendazole Albendazole The metabolism of Albendazole can be increased when combined with Lesinurad.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Lesinurad.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Lesinurad.
Tocilizumab Injection Tocilizumab Injection The metabolism of Lesinurad can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Dalfampridine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Lesinurad.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Pegloticase Injection Pegloticase Injection The risk or severity of adverse effects can be increased when Lesinurad is combined with Pegloticase.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ipilimumab Injection Ipilimumab Injection Ipilimumab may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Lesinurad.
Roflumilast Roflumilast The metabolism of Lesinurad can be increased when combined with Roflumilast.
Linagliptin Linagliptin The metabolism of Linagliptin can be increased when combined with Lesinurad.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Lesinurad can be increased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Lesinurad can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban Rivaroxaban may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ticagrelor Ticagrelor The metabolism of Lesinurad can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Lesinurad.
Ruxolitinib Ruxolitinib The metabolism of Lesinurad can be increased when combined with Ruxolitinib.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Lesinurad.
Clobazam Clobazam Clobazam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Vemurafenib Vemurafenib The metabolism of Lesinurad can be increased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Lesinurad can be decreased when combined with Vismodegib.
Deferiprone Deferiprone Deferiprone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Lesinurad.
Crizotinib Crizotinib The metabolism of Crizotinib can be increased when combined with Lesinurad.
Cabergoline Cabergoline The metabolism of Cabergoline can be increased when combined with Lesinurad.
Naloxone Injection Naloxone Injection Naloxone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Enzalutamide Enzalutamide The metabolism of Lesinurad can be increased when combined with Enzalutamide.
Mirabegron Mirabegron Mirabegron may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Lesinurad can be increased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Bosutinib can be increased when combined with Lesinurad.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Lesinurad can be decreased when combined with Cabozantinib.
Teduglutide Injection Teduglutide Injection Teduglutide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Alogliptin Alogliptin Alogliptin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Ponatinib can be increased when combined with Lesinurad.
Pomalidomide Pomalidomide The metabolism of Lesinurad can be increased when combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Lesinurad.
Apixaban Apixaban The metabolism of Lesinurad can be decreased when combined with Apixaban.
Canagliflozin Canagliflozin Canagliflozin may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The metabolism of Lesinurad can be increased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Lesinurad can be decreased when combined with Ospemifene.
Trametinib Trametinib Trametinib may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Levomilnacipran Levomilnacipran Levomilnacipran may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Vortioxetine Vortioxetine Vortioxetine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Lomitapide Lomitapide The metabolism of Lomitapide can be increased when combined with Lesinurad.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Sofosbuvir Sofosbuvir Sofosbuvir may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast The metabolism of Lesinurad can be increased when combined with Apremilast.
Droxidopa Droxidopa Droxidopa may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Lesinurad can be increased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Lesinurad can be increased when combined with Siltuximab.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Lesinurad.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Oritavancin Injection Oritavancin Injection The metabolism of Lesinurad can be decreased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be increased when combined with Lesinurad.
Suvorexant Suvorexant The metabolism of Suvorexant can be increased when combined with Lesinurad.
Edoxaban Edoxaban Edoxaban may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Olaparib Olaparib The metabolism of Olaparib can be increased when combined with Lesinurad.
Methamphetamine Methamphetamine Metamfetamine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Tasimelteon Tasimelteon The metabolism of Lesinurad can be increased when combined with Tasimelteon.
Nintedanib Nintedanib The metabolism of Nintedanib can be increased when combined with Lesinurad.
Secukinumab Injection Secukinumab Injection The metabolism of Lesinurad can be increased when combined with Secukinumab.
Palbociclib Palbociclib The metabolism of Palbociclib can be increased when combined with Lesinurad.
Lenvatinib Lenvatinib The metabolism of Lesinurad can be decreased when combined with Lenvatinib.
Panobinostat Panobinostat The metabolism of Panobinostat can be increased when combined with Lesinurad.
Haloperidol Injection Haloperidol Injection Haloperidol may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amiloride Amiloride Amiloride may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Macitentan may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Lesinurad.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Lesinurad.
Penicillin G Procaine Injection Penicillin G Procaine Injection Procaine benzylpenicillin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be increased when combined with Lesinurad.
Trabectedin Injection Trabectedin Injection The metabolism of Lesinurad can be increased when combined with Trabectedin.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Lesinurad.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Lesinurad.
Ixazomib Ixazomib The metabolism of Lesinurad can be increased when combined with Ixazomib.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Brivaracetam Injection Brivaracetam Injection Brivaracetam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Venetoclax Venetoclax The metabolism of Venetoclax can be increased when combined with Lesinurad.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Lesinurad can be decreased when combined with Diphenhydramine.
Furosemide Injection Furosemide Injection Furosemide may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The metabolism of Lesinurad can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Lixisenatide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ribociclib Ribociclib The metabolism of Ribociclib can be increased when combined with Lesinurad.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Lesinurad.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Lesinurad may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Lesinurad may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Safinamide Safinamide The metabolism of Lesinurad can be decreased when combined with Safinamide.
Naldemedine Naldemedine Lesinurad may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Lesinurad can be increased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be increased when combined with Lesinurad.
Enasidenib Enasidenib The metabolism of Lesinurad can be increased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Lesinurad.
Benznidazole Benznidazole Lesinurad may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Lesinurad.
Delafloxacin Delafloxacin Lesinurad may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be increased when combined with Lesinurad.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Lesinurad.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection The metabolism of Lesinurad can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide Lesinurad may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Avatrombopag Avatrombopag The metabolism of Lesinurad can be increased when combined with Avatrombopag.
Baricitinib Baricitinib The metabolism of Baricitinib can be increased when combined with Lesinurad.
Lofexidine Lofexidine Lofexidine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Lesinurad may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be increased when combined with Lesinurad.
Cannabidiol Cannabidiol The metabolism of Lesinurad can be decreased when combined with Cannabidiol.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be increased when combined with Lesinurad.
Duvelisib Duvelisib The metabolism of Duvelisib can be increased when combined with Lesinurad.
Stiripentol Stiripentol The metabolism of Lesinurad can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be increased when combined with Lesinurad.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Lesinurad.
Rifamycin Rifamycin The metabolism of Lesinurad can be decreased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Lesinurad can be increased when combined with Prucalopride.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Lesinurad can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be increased when combined with Lesinurad.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be increased when combined with Lesinurad.
Alpelisib Alpelisib The serum concentration of Lesinurad can be decreased when it is combined with Alpelisib.
Solriamfetol Solriamfetol Lesinurad may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Triclabendazole Triclabendazole The metabolism of Lesinurad can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Lesinurad.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Lesinurad.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Lesinurad.
Pitolisant Pitolisant Lesinurad may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Lefamulin Lefamulin The metabolism of Lefamulin can be increased when combined with Lesinurad.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Lesinurad.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Lesinurad.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Lesinurad.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Lesinurad.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Lesinurad.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be decreased when it is combined with Lesinurad.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be increased when combined with Lesinurad.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Lesinurad.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Lesinurad.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Lesinurad.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Lesinurad.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Lesinurad.
Pralsetinib Pralsetinib The metabolism of Lesinurad can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Lesinurad can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine Viloxazine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Lesinurad.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Isotretinoin Isotretinoin Isotretinoin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Floxuridine Floxuridine The metabolism of Lesinurad can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Lesinurad can be decreased when combined with Phenobarbital.
Metaxalone Metaxalone Metaxalone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The metabolism of Lesinurad can be increased when combined with Methotrexate.
Primidone Primidone The metabolism of Lesinurad can be decreased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Lesinurad can be increased when combined with Chlorpromazine.
Diazepam Diazepam Diazepam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Oxazepam Oxazepam Oxazepam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Flurazepam Flurazepam Flurazepam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Clorazepate Clorazepate Clorazepic acid may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Lorazepam Lorazepam The metabolism of Lesinurad can be increased when combined with Lorazepam.
Carmustine Carmustine Carmustine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amantadine Amantadine Amantadine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Codeine Codeine Codeine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Tranylcypromine Tranylcypromine The metabolism of Lesinurad can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine Phenelzine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Lesinurad.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Dapsone Dapsone The metabolism of Lesinurad can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Lesinurad can be decreased when combined with Sulfadiazine.
Methadone Methadone Methadone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Maprotiline Maprotiline Maprotiline may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Azathioprine Azathioprine Azathioprine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Phentermine Phentermine The metabolism of Phentermine can be increased when combined with Lesinurad.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be increased when combined with Lesinurad.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Lesinurad.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Clonidine Clonidine The metabolism of Clonidine can be increased when combined with Lesinurad.
Hydralazine Hydralazine Hydralazine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cimetidine Cimetidine The metabolism of Lesinurad can be decreased when combined with Cimetidine.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Lesinurad.
Clonazepam Clonazepam Clonazepam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Promethazine Promethazine The metabolism of Lesinurad can be decreased when combined with Promethazine.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin The serum concentration of Nitrofurantoin can be increased when it is combined with Lesinurad.
Digoxin Digoxin Lesinurad may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine Chloroquine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Quinine Quinine The metabolism of Lesinurad can be decreased when combined with Quinine.
Triamterene Triamterene Triamterene may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Sulfinpyrazone Sulfinpyrazone The metabolism of Lesinurad can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Lesinurad can be decreased when used in combination with Chlorothiazide.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Lesinurad.
Secobarbital Secobarbital Secobarbital may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Desipramine Desipramine Desipramine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amitriptyline Amitriptyline Amitriptyline may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Imipramine Imipramine Imipramine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Probenecid Probenecid The metabolism of Lesinurad can be decreased when combined with Probenecid.
Quinidine Quinidine The metabolism of Lesinurad can be increased when combined with Quinidine.
Procainamide Procainamide Lesinurad may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid The metabolism of Lesinurad can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Disopyramide Disopyramide Disopyramide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Valproic Acid Valproic Acid The metabolism of Lesinurad can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Lesinurad can be increased when combined with Tamoxifen.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Methimazole Methimazole The metabolism of Lesinurad can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide Chlorpropamide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Tolbutamide Tolbutamide Tolbutamide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Tolazamide Tolazamide Tolazamide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Dextromethorphan Dextromethorphan The metabolism of Lesinurad can be decreased when combined with Dextromethorphan.
Baclofen Baclofen Baclofen may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Lesinurad can be decreased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Lesinurad can be decreased when used in combination with Hydrochlorothiazide.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Propranolol may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be increased when combined with Lesinurad.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Nadolol Nadolol Nadolol may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Flavoxate Flavoxate Flavoxate may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The metabolism of Lesinurad can be decreased when combined with Fluorouracil.
Colchicine Colchicine Colchicine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Dacarbazine Dacarbazine Dacarbazine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Acetazolamide Acetazolamide Acetazolamide may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Pyrantel Pyrantel Pyrantel may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Lesinurad.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be increased when combined with Lesinurad.
Vinblastine Vinblastine The metabolism of Vinblastine can be increased when combined with Lesinurad.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Lesinurad can be increased when combined with Metoprolol.
Aspirin Aspirin The therapeutic efficacy of Lesinurad can be decreased when used in combination with Acetylsalicylic acid.
Salsalate Salsalate Salsalate may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Alprazolam Alprazolam Alprazolam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Temazepam Temazepam Temazepam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Triazolam Triazolam Triazolam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Dicyclomine Dicyclomine Dicyclomine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Propantheline Propantheline Propantheline may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Diltiazem Diltiazem The metabolism of Lesinurad can be decreased when combined with Diltiazem.
Nifedipine Nifedipine Nifedipine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Timolol Timolol Timolol may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Verapamil Verapamil Verapamil may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Pindolol Pindolol Pindolol may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cisplatin Injection Cisplatin Injection Lesinurad may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Bumetanide Bumetanide Bumetanide may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Lesinurad.
Glyburide Glyburide The metabolism of Lesinurad can be decreased when combined with Glyburide.
Glipizide Glipizide Glipizide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Indapamide Indapamide Indapamide may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Amoxicillin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Pentoxifylline Pentoxifylline Pentoxifylline may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Labetalol Labetalol Labetalol may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Auranofin Auranofin Auranofin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Gemfibrozil Gemfibrozil The metabolism of Lesinurad can be decreased when combined with Gemfibrozil.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Lesinurad.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amiodarone Amiodarone The metabolism of Lesinurad can be increased when combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Lovastatin Lovastatin The metabolism of Lesinurad can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin Ciprofloxacin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Fluoxetine Fluoxetine The metabolism of Lesinurad can be decreased when combined with Fluoxetine.
Clozapine Clozapine Clozapine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Estazolam Estazolam Estazolam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Idarubicin Idarubicin The metabolism of Lesinurad can be decreased when combined with Idarubicin.
Didanosine Didanosine Didanosine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Etodolac Etodolac Etodolac may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Felodipine Felodipine The metabolism of Lesinurad can be decreased when combined with Felodipine.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Lesinurad can be decreased when combined with Simvastatin.
Teniposide Injection Teniposide Injection The metabolism of Lesinurad can be increased when combined with Teniposide.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Atovaquone Atovaquone The metabolism of Lesinurad can be decreased when combined with Atovaquone.
Bisoprolol Bisoprolol Bisoprolol may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Zolpidem Zolpidem The metabolism of Lesinurad can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The metabolism of Lesinurad can be increased when combined with Doxazosin.
Isradipine Isradipine Isradipine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Omeprazole Omeprazole The metabolism of Lesinurad can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Cisapride can be increased when combined with Lesinurad.
Fluvastatin Fluvastatin The metabolism of Lesinurad can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Famciclovir Famciclovir The metabolism of Famciclovir can be increased when combined with Lesinurad.
Fluvoxamine Fluvoxamine The metabolism of Lesinurad can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone Nefazodone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Lamotrigine Lamotrigine Lamotrigine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Losartan Losartan The metabolism of Lesinurad can be decreased when combined with Losartan.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Tramadol Tramadol Tramadol may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be increased when combined with Lesinurad.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Lansoprazole Lansoprazole The metabolism of Lesinurad can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Lesinurad can be increased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Lesinurad can be decreased when combined with Nicardipine.
Bupropion Bupropion Bupropion may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ticlopidine Ticlopidine The metabolism of Lesinurad can be increased when combined with Ticlopidine.
Metformin Metformin Metformin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Acarbose Acarbose Acarbose may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Glimepiride Glimepiride The metabolism of Lesinurad can be decreased when combined with Glimepiride.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Ritonavir Ritonavir The metabolism of Lesinurad can be increased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Lesinurad.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Clomipramine Clomipramine The metabolism of Lesinurad can be increased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Lesinurad can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Topiramate Topiramate Topiramate may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Zileuton Zileuton The metabolism of Lesinurad can be decreased when combined with Zileuton.
Valsartan Valsartan The metabolism of Lesinurad can be decreased when combined with Valsartan.
Pramipexole Pramipexole Pramipexole may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Donepezil Donepezil The metabolism of Lesinurad can be decreased when combined with Donepezil.
Nelfinavir Nelfinavir The metabolism of Lesinurad can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Azithromycin can be increased when combined with Lesinurad.
Carvedilol Carvedilol The metabolism of Lesinurad can be decreased when combined with Carvedilol.
Nilutamide Nilutamide The metabolism of Lesinurad can be decreased when combined with Nilutamide.
Flutamide Flutamide Flutamide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Selegiline Selegiline The metabolism of Lesinurad can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Lesinurad can be increased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Lesinurad can be decreased when combined with Sertraline.
Irbesartan Irbesartan The metabolism of Lesinurad can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin Tamsulosin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Quetiapine Quetiapine Quetiapine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Paroxetine Paroxetine The metabolism of Lesinurad can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Lesinurad can be decreased when combined with Tolcapone.
Capecitabine Capecitabine The metabolism of Lesinurad can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Lesinurad can be decreased when combined with Efavirenz.
Abacavir Abacavir Abacavir may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Lesinurad can be decreased when combined with Sildenafil.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Rosiglitazone Rosiglitazone Rosiglitazone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Tolterodine Tolterodine Tolterodine may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Thalidomide Thalidomide The metabolism of Lesinurad can be decreased when combined with Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Nateglinide Nateglinide Nateglinide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Rabeprazole Rabeprazole The metabolism of Lesinurad can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Lesinurad can be decreased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists