Herb & supplement monograph

Aegeline Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Aegeline interacts with medications. The heart of this page is the interaction list — every drug Aegeline is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Aegeline is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Interaction report

Drugs that interact with Aegeline

645 medications have a known interaction with Aegeline, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
Ado-trastuzumab EmtansineKadcyla› AbemaciclibVerzenio› Abiraterone› Abiraterone AcetateYonsa, Zytiga› AcalabrutinibCalquence› Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine› Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more› Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine› Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound› Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more› Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3› Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS› Acetaminophen, Caffeine, IsomethepteneMigralam› Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual› Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief› Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex› Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief› Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength› Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG› Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid› Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR› Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin› Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule› Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus› Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more› Acetaminophen, DextromethorphanTylenol Cough Ex Strength› Acetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil› Acetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Aegeline combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Aegeline affects

Every type of medication (drug category) Aegeline is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Aegeline interacts with
Cytochrome P450 3a4 (cyp3a4) Substrates
Cytochrome P450 3A4 (Cyp3A4) Substrates

Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro. So far, this interaction has not been reported in humans. Theoretically, aegeline may increase levels of drugs metabolized by CYP3A4. Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and numerous others. Use aegeline cautiously or avoid in patients taking these drugs.

Likelihood Possible Evidence D
Monograph

Aegeline: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Aegeline is a compound originally identified in the bael tree (Aegle marmelos) that gained attention because it was added to some weight-loss and workout supplements. It is best known for being linked to serious liver injury in a product called OxyELITE Pro, and U.S. regulators warned against products containing it. There is no good evidence it safely helps with weight loss, and it should generally be avoided.

Part used
Derived from compounds found in Aegle marmelos (bael tree); aegeline is also made synthetically
Common forms
Capsules and tablets (historically in some weight-loss and sports supplements)
People commonly use it for
  • Weight loss
  • Fat burning / metabolism support
  • Sports and bodybuilding supplements
  • General 'energy' products

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallBest avoided

Aegeline-containing supplements have been linked to serious liver injury and regulatory warnings.

PregnancyInsufficient reliable information

Insufficient reliable information is available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information is available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Aegeline is a chemical compound that was originally found in the bael tree (Aegle marmelos), a plant native to India and Southeast Asia whose fruit and leaves have a long history in traditional medicine. The version used in supplements has also been made synthetically.

Aegeline became widely known when it was added to certain dietary supplements marketed for weight loss and for bodybuilding, most notably a product called OxyELITE Pro. Around 2013, this product was linked to a cluster of serious liver illnesses in the United States, which led to investigations and recalls.

Today, aegeline is not a common or trusted ingredient. The U.S. Food and Drug Administration has taken the position that it is not a lawful dietary ingredient, and reputable manufacturers generally do not use it.

Uses & effectiveness

People have mainly encountered aegeline in weight-loss and fat-burning supplements, and in some sports and bodybuilding products marketed for energy and metabolism.

The evidence that aegeline actually helps with any of these goals in humans is very limited and not reliable. There are no good-quality human clinical trials showing it safely supports weight loss. What it is best documented for is the opposite of a benefit: a connection to cases of serious liver injury.

Because of the safety concerns and the lack of proven benefit, aegeline cannot be recommended for any use.

How it works

Aegeline is studied mostly in laboratory and animal research. Early studies suggested it might affect blood sugar and fat (lipid) levels in animals, which is part of why it was promoted in weight-loss products. These findings are preliminary and do not prove the same effects, or safety, in people.

The exact way aegeline acts in the human body is not well understood. Importantly, the mechanism behind its possible harm — the liver injury reported in some users — is also not fully explained, which adds to the concern about using it.

Safety & precautions

Aegeline is a clear caution-to-avoid ingredient. Supplements containing it have been associated with cases of acute liver injury, including serious cases that required medical care and, in some reports, were life-threatening. U.S. regulators have warned the public and pulled affected products from the market.

People with any liver problems, or who take other medicines or supplements that can stress the liver, are at especially high risk and should not use it. Anyone who has taken an aegeline-containing product and develops symptoms such as yellowing of the skin or eyes, dark urine, severe fatigue, nausea, or belly pain should stop and seek medical care right away.

Pregnancy and breastfeeding: There is no safety information for these groups. Given the known liver risk, aegeline should be avoided if you are pregnant or breastfeeding.

Side effects

The most important reported harm is liver injury (hepatotoxicity), which can be serious. Warning signs include yellowing of the skin or eyes (jaundice), dark urine, light-colored stools, unusual tiredness, loss of appetite, nausea, vomiting, and pain in the upper-right belly.

Other effects reported with the multi-ingredient products that contained aegeline have included nausea and general gastrointestinal upset, but because these products had several ingredients, it is hard to attribute every symptom to aegeline alone. The bottom line is that any sign of liver trouble is a medical emergency.

Aegeline: Reported Adverse Effects

Documented safety reports on Aegeline from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, numerous cases of severe acute hepatitis, occasionally resulting in death, have been associated with use of a specific product containing synthetic aegeline (Super Thermo OxyELITE Pro).

  1. Johnston DI, Chang A, Viray M, et al. Hepatotoxicity associated with the dietary supplement OxyELITE Pro - Hawaii, 2013. Drug Test Anal. 2016;8(3-4):319-27.
  2. Chatham-Stephens K, Taylor E, Chang A, et al. Hepatotoxicity associated with weight loss or sports dietary supplements, including OxyELITE Pro - United States, 2013. Drug Test Anal. 2017;9(1):68-74.
  3. Heidemann LA, Navarro VJ, Ahmad J, et al. Severe acute hepatocellular injury attributed to OxyELITE Pro: A case series. Dig Dis Sci. 2016;61(9):2741-8.
  4. Roytman MM, Pörzgen P, Lee CL, et al. Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro. Am J Gastroenterol. 2014;109(8):1296-8.
  5. Skinner CM, Miousse IR, Ewing LE, et al. Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food Chem Toxicol. 201
Reports by condition
Fatigue Hepatic

There are numerous case reports of severe acute hepatitis with fulminant liver failure associated with use of a specific multi-ingredient product containing aegeline (Super Thermo OxyELITE Pro). Symptoms included elevated liver enzymes, dark urine, jaundice, loss of appetite, nausea, abdominal pain, and fatigue. Onset of liver injury typically occurred in patients 2-20 weeks after beginning regular use of this product. Liver transplant was required in at least five cases, and there were at least two deaths. The aegeline included in this product was synthesized by a Chinese manufacturer; the purity of this ingredient or whether it was identical to the constituent of the bael plant where it is found naturally is unclear. However, there is evidence from feeding trials in rats showing that the bael plant, which contains aegeline, can cause hepatic lesions.

  1. Johnston DI, Chang A, Viray M, et al. Hepatotoxicity associated with the dietary supplement OxyELITE Pro - Hawaii, 2013. Drug Test Anal. 2016;8(3-4):319-27.
  2. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. OxyELITE Pro. [Updated 2016 May 20]. Available from: https://www.ncbi.nlm.nih.gov/
  3. Chatham-Stephens K, Taylor E, Chang A, et al. Hepatotoxicity associated with weight loss or sports dietary supplements, including OxyELITE Pro - United States, 2013. Drug Test Anal. 2017;9(1):68-74.
  4. Heidemann LA, Navarro VJ, Ahmad J, et al. Severe acute hepatocellular injury attributed to OxyELITE Pro: A case series. Dig Dis Sci. 2016;61(9):2741-8.
  5. Roytman MM, Pörzgen P, Lee CL, et al. Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro. Am J Gastroenterol. 2014;109(8):1296-8.
  6. Klontz KC, DeBeck HJ, LeBlanc P, et al. The Role of Adverse Event Reporting in the FDA Response to a Multistate Outbreak of Liver Disease Associated with a Dietary Supplement. Public Health Rep. 2015;130(5):526-532.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established safe or effective dose of aegeline. Because it has been linked to liver injury and is not considered a lawful dietary ingredient in the United States, there is no recommended amount.

We do not recommend taking aegeline. If you come across a supplement that lists aegeline on the label, talk with a pharmacist or doctor before using it, and consider choosing a different, better-studied product.

Pregnancy & Breastfeeding

Aegeline & Pregnancy

Insufficient reliable information

Insufficient reliable information is available; avoid using.

Aegeline & Breastfeeding

Insufficient reliable information

Insufficient reliable information is available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 8 references that drive our Aegeline monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Johnston DI, Chang A, Viray M, et al. Hepatotoxicity associated with the dietary supplement OxyELITE Pro - Hawaii, 2013. Drug Test Anal. 2016;8(3-4):319-27. PubMed
  2. Manda VK, Avula B, Chittiboyina AG, Khan IA, Walker LA, Khan SI. Inhibition of CYP3A4 and CYP1A2 by Aegle marmelos and its constituents. Xenobiotica. 2016;46(2):117-25.
  3. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. OxyELITE Pro. [Updated 2016 May 20]. Available from: https://www.ncbi.nlm.nih.gov/
  4. Klontz KC, DeBeck HJ, LeBlanc P, et al. The Role of Adverse Event Reporting in the FDA Response to a Multistate Outbreak of Liver Disease Associated with a Dietary Supplement. Public Health Rep. 2015;130(5):526-532. PubMed
  5. Chatham-Stephens K, Taylor E, Chang A, et al. Hepatotoxicity associated with weight loss or sports dietary supplements, including OxyELITE Pro - United States, 2013. Drug Test Anal. 2017;9(1):68-74. PubMed
  6. Heidemann LA, Navarro VJ, Ahmad J, et al. Severe acute hepatocellular injury attributed to OxyELITE Pro: A case series. Dig Dis Sci. 2016;61(9):2741-8. PubMed
  7. Roytman MM, Pörzgen P, Lee CL, et al. Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro. Am J Gastroenterol. 2014;109(8):1296-8. PubMed
  8. Skinner CM, Miousse IR, Ewing LE, et al. Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food Chem Toxicol. 201 PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Aegeline

1 brand in our database make a supplement containing Aegeline.

Product directory

Supplement products with Aegeline

7 products in our database contain Aegeline. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Aegeline: Common Questions

Does Aegeline interact with prescription medications?
Yes. We list 645 medications with a known interaction with Aegeline. Use the checker above to see how Aegeline interacts with a specific drug.
How are Aegeline interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Aegeline with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Aegeline interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Aegeline used for?
It was added to some weight-loss and bodybuilding supplements, but there is no reliable evidence it works, and it has been linked to serious liver injury.
Is Aegeline safe?
No. Supplements containing Aegeline have been associated with serious liver injury, and U.S. regulators have warned against products that contain it.
Can I take Aegeline if I'm pregnant or breastfeeding?
No. There is no safety data, and because of the known liver risk it should be avoided during pregnancy and breastfeeding.
What should I do if I took a supplement with Aegeline?
Stop using it and watch for liver-injury symptoms like jaundice, dark urine, severe tiredness, or belly pain; seek medical care promptly if any appear.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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