Drug & supplement interaction

Aegeline + Diphenhydramine Hydrochloride, Naproxen Sodium

Diphenhydramine Hydrochloride, Naproxen Sodium brand name: Aleve PM.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Aegeline and Diphenhydramine Hydrochloride, Naproxen Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Diphenhydramine Hydrochloride, Naproxen Sodium states a food rule worth keeping to.

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Interaction report

Aegeline and Diphenhydramine Hydrochloride, Naproxen Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diphenhydramine Hydrochloride, Naproxen Sodium and Aegeline in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Aegeline safety at a glance

Aegeline overall Avoid Aegeline-containing supplements have been linked to serious liver injury and regulatory warnings.
Pregnancy Avoid No safety data; avoid during pregnancy.
Breastfeeding Avoid No safety data; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diphenhydramine Hydrochloride, Naproxen Sodium and Aegeline? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Diphenhydramine Hydrochloride, Naproxen Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Diphenhydramine Hydrochloride, Naproxen Sodium is filed under 14 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), cytochrome p450 2c9 (cyp2c9) substrates, anticoagulant/antiplatelet drugs. Aegeline has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) substrates (minor) — and none of Diphenhydramine Hydrochloride, Naproxen Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Aegeline Does Interact With Other Medications

Aegeline has 643 minor known drug interactions in our database — Diphenhydramine Hydrochloride, Naproxen Sodium isn’t one of them. If you take anything else, check it against the full list below.

Minor 643 No known interaction 2,187 (incl. Diphenhydramine Hydrochloride, Naproxen Sodium)
Taking anything else?

Check Another of Your Medications Against Aegeline

Covers the 2,830 medications we’ve checked against Aegeline. Pick one to open its full report.

What to actually watch for

What Aegeline Itself Has Been Linked To

This is not an interaction — nothing below involves Diphenhydramine Hydrochloride, Naproxen Sodium. It is the side-effect record for Aegeline on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Aegeline, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Yellowing of the skin or eyes Worth acting on Additional detail

    “There are numerous case reports of severe acute hepatitis with fulminant liver failure associated with use of a specific multi-ingredient product containing aegeline (Super Thermo OxyELITE Pro). Symptoms included elevated liver enzymes, dark urine, jaundice, loss of appetite, nausea, abdominal pain, and fatigue.”

    Aegeline · Natural Medicines adverse-effect record, reported in fatigue.

    6 sources cited
    1. 90904. Johnston DI, Chang A, Viray M, et al. Hepatotoxicity associated with the dietary supplement OxyELITE Pro - Hawaii, 2013. Drug Test Anal. 2016;8(3-4):319-27. PubMed
    2. 101520. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. OxyELITE Pro. [Updated 2016 May 20]. Available from: https://www.ncbi.nlm.nih.gov/
    3. 102777. Chatham-Stephens K, Taylor E, Chang A, et al. Hepatotoxicity associated with weight loss or sports dietary supplements, including OxyELITE Pro - United States, 2013. Drug Test Anal. 2017;9(1):68-74. PubMed
    4. 102779. Heidemann LA, Navarro VJ, Ahmad J, et al. Severe acute hepatocellular injury attributed to OxyELITE Pro: A case series. Dig Dis Sci. 2016;61(9):2741-8. PubMed
    5. 102780. Roytman MM, Pörzgen P, Lee CL, et al. Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro. Am J Gastroenterol. 2014;109(8):1296-8. PubMed
    6. 101521. Klontz KC, DeBeck HJ, LeBlanc P, et al. The Role of Adverse Event Reporting in the FDA Response to a Multistate Outbreak of Liver Disease Associated with a Dietary Supplement. Public Health Rep. 2015;130(5):526-532. PubMed
  • Liver problems Worth acting on Additional detail

    “Orally, numerous cases of severe acute hepatitis, occasionally resulting in death, have been associated with use of a specific product containing synthetic aegeline (Super Thermo OxyELITE Pro).”

    Aegeline · Natural Medicines adverse-effect record, reported in hepatitis.

    5 sources cited
    1. 90904. Johnston DI, Chang A, Viray M, et al. Hepatotoxicity associated with the dietary supplement OxyELITE Pro - Hawaii, 2013. Drug Test Anal. 2016;8(3-4):319-27. PubMed
    2. 102777. Chatham-Stephens K, Taylor E, Chang A, et al. Hepatotoxicity associated with weight loss or sports dietary supplements, including OxyELITE Pro - United States, 2013. Drug Test Anal. 2017;9(1):68-74. PubMed
    3. 102779. Heidemann LA, Navarro VJ, Ahmad J, et al. Severe acute hepatocellular injury attributed to OxyELITE Pro: A case series. Dig Dis Sci. 2016;61(9):2741-8. PubMed
    4. 102780. Roytman MM, Pörzgen P, Lee CL, et al. Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro. Am J Gastroenterol. 2014;109(8):1296-8. PubMed
    5. 102781. Skinner CM, Miousse IR, Ewing LE, et al. Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food Chem Toxicol. 201 PubMed
  • Reduced appetite / Stomach pain / Tiredness / Nausea Additional detail

    Recorded for Aegeline in the same Natural Medicines adverse-effect record shown under Yellowing of the skin or eyes above.

Everything above comes from the Natural Medicines adverse-effect record for Aegeline — expand a row for the licensed statement it rests on. We haven’t matched Diphenhydramine Hydrochloride, Naproxen Sodium to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Diphenhydramine Hydrochloride, Naproxen Sodium.

How to take them

Some Diphenhydramine Hydrochloride, Naproxen Sodium Products Have a Food Rule — Aegeline Should Not Break It

At least one FDA label for a product containing Diphenhydramine Hydrochloride, Naproxen Sodium says to take it with food. If you take Aegeline on an empty stomach out of habit, keep them separate — and take Diphenhydramine Hydrochloride, Naproxen Sodium with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Diphenhydramine Hydrochloride, Naproxen Sodium products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Directions • do not take more than directed • drink a full glass of water with each dose • adults and children 12 years and over: take 2 caplets at bedtime • do not take more than 2 caplets in 24 hours • if taken with food, this product may take longer to work

From the Dosage and Administration section of the FDA label we read for Diphenhydramine Hydrochloride, Naproxen Sodium — where that label names a specific product, the instruction is that product's.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Diphenhydramine Hydrochloride, Naproxen Sodium

This page covers Aegeline only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diphenhydramine Hydrochloride, Naproxen Sodium page lists 378 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 13 major · 320 moderate · 45 minor.

From our pharmacist’s overview on the Diphenhydramine Hydrochloride, Naproxen Sodium page

“Aleve PM combines naproxen, an NSAID, with the sedating antihistamine diphenhydramine, and its supplement list earns genuine care rather than a quick skim. Thirteen of the 378 ingredients on file rate major, and the two largest themes track the pill's two halves.”

Reviewed by 2 · Jul 18, 2026

Open the Diphenhydramine Hydrochloride, Naproxen Sodium interaction page

One more smart check

Taking Aegeline as Part of a Dietary Supplement Product? Check It for Interactions

We hold 7 real supplement products containing Aegeline, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Aegeline. Even though Aegeline itself has no known interaction with Diphenhydramine Hydrochloride, Naproxen Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Aegeline and Diphenhydramine Hydrochloride, Naproxen Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Aegeline
Steady interest

#978 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diphenhydramine Hydrochloride, Naproxen Sodium
Top 5%

#134 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Aegeline reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Aegeline and Diphenhydramine Hydrochloride, Naproxen Sodium records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Aegeline

What is Aegeline?

  • Weight loss
  • Fat burning / metabolism support
  • Sports and bodybuilding supplements
  • General 'energy' products

Aegeline is a compound originally identified in the bael tree (Aegle marmelos) that gained attention because it was added to some weight-loss and workout supplements. It is best known for being linked to serious liver injury in a product called OxyELITE Pro, and U.S. regulators warned against products containing it. There is no good evidence it safely helps with weight loss, and it should generally be avoided.

Derived from compounds found in Aegle marmelos (bael tree); aegeline is also made synthetically · Capsules and tablets (historically in some weight-loss and sports supplements)

An interaction check asks whether these two react with each other — it does not ask whether Aegeline is a good idea for someone in your situation. Here is what our Aegeline record says about it on its own.

Aegeline: dosing

There is no established safe or effective dose of aegeline. Because it has been linked to liver injury and is not considered a lawful dietary ingredient in the United States, there is no recommended amount.We do not recommend taking aegeline.

From our Aegeline monograph — the full record covers uses, side effects and every documented interaction.

Read the full Aegeline monograph & all interactions
Keep checking

Other Drugs & Aegeline

Browse every other medication we’ve checked against Aegeline — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
643Minor
2,186No known interaction
643 Minor 2,186 No interaction
Minor

643 interactions

Showing 60 of 643 minor interactions — see all 643 on the Aegeline page.

No interaction 2,186 drugs checked — show the list

We also checked Aegeline against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,186 medications checked with no known interaction — see the full Aegeline list.

See the full Aegeline interactions page
See every supplement checked against Diphenhydramine Hydrochloride, Naproxen Sodium, ranked by severity
Evidence & sources

Aegeline References

The 8 references that drive our Aegeline monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Johnston DI, Chang A, Viray M, et al. Hepatotoxicity associated with the dietary supplement OxyELITE Pro - Hawaii, 2013. Drug Test Anal. 2016;8(3-4):319-27. PubMed
  2. Manda VK, Avula B, Chittiboyina AG, Khan IA, Walker LA, Khan SI. Inhibition of CYP3A4 and CYP1A2 by Aegle marmelos and its constituents. Xenobiotica. 2016;46(2):117-25.
  3. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. OxyELITE Pro. [Updated 2016 May 20]. Available from: https://www.ncbi.nlm.nih.gov/
  4. Klontz KC, DeBeck HJ, LeBlanc P, et al. The Role of Adverse Event Reporting in the FDA Response to a Multistate Outbreak of Liver Disease Associated with a Dietary Supplement. Public Health Rep. 2015;130(5):526-532. PubMed
  5. Chatham-Stephens K, Taylor E, Chang A, et al. Hepatotoxicity associated with weight loss or sports dietary supplements, including OxyELITE Pro - United States, 2013. Drug Test Anal. 2017;9(1):68-74. PubMed
  6. Heidemann LA, Navarro VJ, Ahmad J, et al. Severe acute hepatocellular injury attributed to OxyELITE Pro: A case series. Dig Dis Sci. 2016;61(9):2741-8. PubMed
  7. Roytman MM, Pörzgen P, Lee CL, et al. Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro. Am J Gastroenterol. 2014;109(8):1296-8. PubMed
  8. Skinner CM, Miousse IR, Ewing LE, et al. Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food Chem Toxicol. 201 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Aegeline and Diphenhydramine Hydrochloride, Naproxen Sodium Together: Common Questions

Is it safe to take Aegeline with Diphenhydramine Hydrochloride, Naproxen Sodium?
We do not list a known interaction between Aegeline and Diphenhydramine Hydrochloride, Naproxen Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Aegeline and Diphenhydramine Hydrochloride, Naproxen Sodium at the same time of day?
At least one FDA label for a product containing Diphenhydramine Hydrochloride, Naproxen Sodium says to take it with food. If you take Aegeline on an empty stomach out of habit, keep them separate and take Diphenhydramine Hydrochloride, Naproxen Sodium with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Diphenhydramine Hydrochloride, Naproxen Sodium products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Aegeline and Diphenhydramine Hydrochloride, Naproxen Sodium combination checked?
Interactions in our licensed database are recorded against drug classes. Diphenhydramine Hydrochloride, Naproxen Sodium is filed under 14 classifications, and Aegeline has documented interactions with 1 drug class — none of Diphenhydramine Hydrochloride, Naproxen Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Aegeline interact with any other medications?
Yes. Aegeline has 643 documented drug interactions in our database — Diphenhydramine Hydrochloride, Naproxen Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Diphenhydramine Hydrochloride, Naproxen Sodium interact with any supplements?
Yes. Diphenhydramine Hydrochloride, Naproxen Sodium has documented interactions with 378 supplements in our database — Aegeline is not one of them. The Diphenhydramine Hydrochloride, Naproxen Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Aegeline monograph Uses, safety profile, and every drug interaction in one place Diphenhydramine Hydrochloride, Naproxen Sodium supplement interactions Every supplement checked against Diphenhydramine Hydrochloride, Naproxen Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diphenhydramine Hydrochloride, Naproxen Sodium and Aegeline?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.