Herb & supplement monograph

Duckweed Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Duckweed

0 medications have a known interaction with Duckweed, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Duckweed. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Duckweed combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Duckweed: Uses, Safety & Side Effects

The bottom line

Duckweed is a tiny floating water plant being studied as a nutrient-dense, plant-based protein and food source. Human evidence for any specific health benefit is very limited, and safety depends heavily on the plant being grown in clean, uncontaminated water. Talk to a pharmacist or doctor before using it as a supplement.

Family
Lemnaceae
Part used
Whole plant (fronds)
Common forms
Powder, capsules, tablets, dried whole plant, protein supplements, traditional decoctions
People commonly use it for
  • Plant-based protein source
  • Source of vitamins and minerals
  • Traditional remedy for fever and inflammation
  • Skin conditions and rashes
  • General nutrition and wellness

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally considered a food in some cultures, but supplement quality and water contamination are real concerns.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Duckweed is a group of very small, free-floating aquatic plants found in ponds, lakes, and slow-moving water around the world. The plants belong to the family Lemnaceae and include genera such as Lemna, Spirodela, and Wolffia. Some of the smallest flowering plants on Earth are duckweeds.

Duckweed has long been eaten in parts of Southeast Asia, where certain species (sometimes called "water meal" or "khai-nam") are used as a vegetable. More recently, it has gained attention as a fast-growing, protein-rich crop that could be used for food, animal feed, and supplements.

In supplement form, duckweed is usually sold as a dried powder, capsule, or protein product. It is promoted mainly as a plant-based source of protein, vitamins, and minerals rather than as a treatment for any specific disease.

How it works

Duckweed's appeal is largely nutritional. Depending on the species and growing conditions, it can contain protein, fiber, omega-3 fatty acids, carotenoids, and various vitamins and minerals. These nutrients are the proposed basis for its use as a food and supplement.

Laboratory studies have also looked at plant compounds in duckweed, such as flavonoids and other antioxidants, which may have anti-inflammatory or antioxidant activity in test-tube settings. It is important to understand that these findings come mostly from cell and animal research and do not prove benefits in people.

Because duckweed absorbs substances from the water it grows in, its exact nutrient content—and its safety—can vary a lot from one batch to another.

Effectiveness

Does Duckweed work?

Evidence overview · 3 uses evaluated
3 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Duckweed, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Gout
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical duckweed for gout, there is insufficient reliable information about the clinical effects of duckweed for this condition.

Insufficient Reliable Evidence To Rate Respiratory tract infections
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral duckweed for respiratory tract infections, such as bronchitis, there is insufficient reliable information about the clinical effects of duckweed for this purpose.

Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical duckweed for RA, there is insufficient reliable information about the clinical effects of duckweed for this condition.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Duckweed eaten as a traditional food is generally considered safe when it is grown in clean water and properly prepared. The biggest safety concern is contamination: because duckweed soaks up whatever is in its water, plants grown in polluted ponds can take up heavy metals, harmful bacteria, or toxins. For this reason, only products from controlled, food-grade growing systems should be used.

People with kidney problems, those who need to watch their potassium or mineral intake, and anyone with a history of allergies should be especially careful and check with a healthcare provider first.

Pregnancy and breastfeeding: There is not enough reliable information to know whether duckweed supplements are safe during pregnancy or while breastfeeding. To be safe, women who are pregnant or nursing should avoid duckweed supplements unless a doctor advises otherwise.

Always choose products from reputable companies that test for contaminants, and talk with a pharmacist or doctor before starting any new supplement.

Side effects

Because high-quality human studies are lacking, the full side-effect profile of duckweed supplements is not well known. When eaten as a clean, properly grown food, it is usually well tolerated.

Possible side effects may include digestive upset, such as gas, bloating, or stomach discomfort, especially when starting a new supplement. Allergic reactions are also possible, as with any plant product.

The more serious risks are tied to contaminated duckweed—plants grown in dirty water can carry heavy metals or microbes that may cause illness. Stop using the product and seek medical care if you develop a rash, swelling, trouble breathing, or significant stomach symptoms.

Dosing

There is no official, standardized dose for duckweed supplements. The right amount has not been established in clinical research, and products vary widely in concentration and form.

If you choose to use a duckweed product, follow the directions on the label and do not exceed the recommended amount. Because nutrient and contaminant levels can differ between brands, it is best to pick a product that has been tested for purity.

Check with a pharmacist or doctor before starting, especially if you take other medications, have a chronic health condition, or are pregnant or breastfeeding.

Pregnancy & Breastfeeding

Duckweed & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Duckweed & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 sources that drive our Duckweed monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.

  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Brand directory

Brands that make products with Duckweed

1 brand in our database make a supplement containing Duckweed.

Pharmacist Counseling Corner

Duckweed: Common Questions

What is Duckweed used for, and does it work?
People use Duckweed for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Duckweed interact with prescription medications?
We do not currently list any known drug interactions for Duckweed. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Duckweed interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Duckweed with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Duckweed interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Duckweed used for?
It is used mainly as a plant-based source of protein, vitamins, and minerals, and in some traditions for fevers, swelling, and skin problems. Strong human evidence for specific health benefits is lacking.
Is Duckweed safe to eat?
Duckweed grown in clean, controlled water and properly prepared is eaten as a food in some cultures. The main risk is contamination, so only use products from reputable, food-grade sources.
Can I take Duckweed while pregnant or breastfeeding?
There is not enough reliable safety information, so it is best to avoid Duckweed supplements during pregnancy and breastfeeding unless your doctor says otherwise.
How is Duckweed taken as a supplement?
It is usually sold as a dried powder, capsule, tablet, or protein product. Because there is no standardized dose, follow the product label and check with a pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Duckweed

A rotating sample of real supplements in our database that list Duckweed — open any to see its full ingredients and every drug interaction we check.

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