Duckweed Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Duckweed interacts with medications. The heart of this page is the interaction list — every drug Duckweed is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Duckweed is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Duckweed against your medication
Add one medicationDrugs that interact with Duckweed
0 medications have a known interaction with Duckweed, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Duckweed. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Duckweed combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Duckweed: Uses, Safety & Side Effects
Duckweed is a tiny floating water plant being studied as a nutrient-dense, plant-based protein and food source. Human evidence for any specific health benefit is very limited, and safety depends heavily on the plant being grown in clean, uncontaminated water. Talk to a pharmacist or doctor before using it as a supplement.
- Family
- Lemnaceae
- Part used
- Whole plant (fronds)
- Common forms
- Powder, capsules, tablets, dried whole plant, protein supplements, traditional decoctions
- Plant-based protein source
- Source of vitamins and minerals
- Traditional remedy for fever and inflammation
- Skin conditions and rashes
- General nutrition and wellness
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally considered a food in some cultures, but supplement quality and water contamination are real concerns.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Duckweed is a group of very small, free-floating aquatic plants found in ponds, lakes, and slow-moving water around the world. The plants belong to the family Lemnaceae and include genera such as Lemna, Spirodela, and Wolffia. Some of the smallest flowering plants on Earth are duckweeds.
Duckweed has long been eaten in parts of Southeast Asia, where certain species (sometimes called "water meal" or "khai-nam") are used as a vegetable. More recently, it has gained attention as a fast-growing, protein-rich crop that could be used for food, animal feed, and supplements.
In supplement form, duckweed is usually sold as a dried powder, capsule, or protein product. It is promoted mainly as a plant-based source of protein, vitamins, and minerals rather than as a treatment for any specific disease.
How it works
Duckweed's appeal is largely nutritional. Depending on the species and growing conditions, it can contain protein, fiber, omega-3 fatty acids, carotenoids, and various vitamins and minerals. These nutrients are the proposed basis for its use as a food and supplement.
Laboratory studies have also looked at plant compounds in duckweed, such as flavonoids and other antioxidants, which may have anti-inflammatory or antioxidant activity in test-tube settings. It is important to understand that these findings come mostly from cell and animal research and do not prove benefits in people.
Because duckweed absorbs substances from the water it grows in, its exact nutrient content—and its safety—can vary a lot from one batch to another.
Does Duckweed work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Duckweed, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Gout
Although there is interest in using topical duckweed for gout, there is insufficient reliable information about the clinical effects of duckweed for this condition.
Insufficient Reliable Evidence To Rate Respiratory tract infections
Although there is interest in using oral duckweed for respiratory tract infections, such as bronchitis, there is insufficient reliable information about the clinical effects of duckweed for this purpose.
Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Although there is interest in using topical duckweed for RA, there is insufficient reliable information about the clinical effects of duckweed for this condition.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Duckweed eaten as a traditional food is generally considered safe when it is grown in clean water and properly prepared. The biggest safety concern is contamination: because duckweed soaks up whatever is in its water, plants grown in polluted ponds can take up heavy metals, harmful bacteria, or toxins. For this reason, only products from controlled, food-grade growing systems should be used.
People with kidney problems, those who need to watch their potassium or mineral intake, and anyone with a history of allergies should be especially careful and check with a healthcare provider first.
Pregnancy and breastfeeding: There is not enough reliable information to know whether duckweed supplements are safe during pregnancy or while breastfeeding. To be safe, women who are pregnant or nursing should avoid duckweed supplements unless a doctor advises otherwise.
Always choose products from reputable companies that test for contaminants, and talk with a pharmacist or doctor before starting any new supplement.
Side effects
Because high-quality human studies are lacking, the full side-effect profile of duckweed supplements is not well known. When eaten as a clean, properly grown food, it is usually well tolerated.
Possible side effects may include digestive upset, such as gas, bloating, or stomach discomfort, especially when starting a new supplement. Allergic reactions are also possible, as with any plant product.
The more serious risks are tied to contaminated duckweed—plants grown in dirty water can carry heavy metals or microbes that may cause illness. Stop using the product and seek medical care if you develop a rash, swelling, trouble breathing, or significant stomach symptoms.
Dosing
There is no official, standardized dose for duckweed supplements. The right amount has not been established in clinical research, and products vary widely in concentration and form.
If you choose to use a duckweed product, follow the directions on the label and do not exceed the recommended amount. Because nutrient and contaminant levels can differ between brands, it is best to pick a product that has been tested for purity.
Check with a pharmacist or doctor before starting, especially if you take other medications, have a chronic health condition, or are pregnant or breastfeeding.
Duckweed & Pregnancy
Duckweed & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 2 sources that drive our Duckweed monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
- Using Dietary Supplements Wisely — NIH NCCIH Source
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Brands that make products with Duckweed
1 brand in our database make a supplement containing Duckweed.
Supplement products with Duckweed
6 products in our database contain Duckweed. Open any to see its full ingredient list and every drug interaction we check.
Duckweed: Common Questions
What is Duckweed used for, and does it work?
Does Duckweed interact with prescription medications?
How are Duckweed interactions rated?
Is it safe to take Duckweed with my medications?
Where does this Duckweed interaction information come from?
What is Duckweed used for?
Is Duckweed safe to eat?
Can I take Duckweed while pregnant or breastfeeding?
How is Duckweed taken as a supplement?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Duckweed
A rotating sample of real supplements in our database that list Duckweed — open any to see its full ingredients and every drug interaction we check.
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